Tag: Cytochrome

Impact of Pregnancy and Vitamin A Supplementation on CYP2D6 Activity

doi: 10.1002/jcph.2169. Online ahead of print. Ogochukwu U Amaeze  1 , Lindsay C Czuba  1 , Aprajita S Yadav  1 , Emily E Fay  2 , Jeffrey LaFrance  1 , Sara Shum  1 , Sue L Moreni  2 , Jennie Mao  2 , Weize Huang  1 , Nina Isoherranen  1   3 , Mary F Hebert  2   4 Affiliations…

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Remarkably low host specificity in the bat fly Penicillidia fulvida (Diptera: Nycteribiidae) as assessed by mitochondrial COI and nuclear 28S sequence data | Parasites & Vectors

Zachos FE. Species concepts in biology: historical development, theoretical foundations and practical relevance. Berlin: Springer; 2016. Google Scholar  Perkins SL. Species concepts and malaria parasites: detecting a cryptic species of Plasmodium. Proc Biol Sci. 2000;267:2345–50. CAS  PubMed  PubMed Central  Google Scholar  Mayr E. Systematics and the origin of species. New…

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Modelling urea cycle disorders using iPSCs

Gebhardt, R. & Matz-Soja, M. Liver zonation: Novel aspects of its regulation and its impact on homeostasis. World J. Gastroenterol. 20, 8491–8504 (2014). PubMed  PubMed Central  Article  Google Scholar  Summar, M. L. et al. The incidence of urea cycle disorders. Mol. Genet Metab. 110, 179–180 (2013). CAS  PubMed  PubMed Central …

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An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes

Title: An Examination of IC50 and IC50-Shift Experiments in Assessing Time-Dependent Inhibition of CYP3A4, CYP2D6 and CYP2C9 in Human Liver Microsomes Volume: 2 Issue: 1 Author(s): Loren M. Berry and Zhiyang Zhao Affiliation: Keywords: Cytochrome P450, drug interactions, in vitro models, inhibition, microsomes, time-dependent inactivation Abstract: The relationship between time-dependent…

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Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan

Abstract The cytochrome P450 2D6 (CYP2D6) is a key xenobiotic-metabolizing enzyme involved in the clearance of many drugs. Genetic polymorphisms in CYP2D6 contribute to the large inter-individual variability in drug metabolism and could affect metabolic phenotyping of CYP2D6 probe substances such as dextromethorphan (DXM). To study this question, we (i)…

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Nitrogen cycling and microbial cooperation in the terrestrial subsurface

Distribution of nitrogen-cycling pathways in groundwater Differences in nitrogen-cycling processes based on oxygen and nitrate concentrations Sixteen metagenomes (Table S4) were obtained from duplicate wells at four sites (A–D) from two unconfined alluvial aquifers (Canterbury, Fig. S1). These sites encompassed varied nitrate (0.45–12.6 g/m3), DO (0.37–7.5 mg/L), and dissolved organic carbon (DOC) (0–26 g/m3)…

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Dietary selection of metabolically distinct microorganisms drives hydrogen metabolism in ruminants

Volatile fatty acid production and absorption is modulated by diet Animals were adapted to a starch-rich diet by gradually increasing dietary concentrate content from 50 to 90% over the three 100-d experimental periods (Fig. 1A). With both diets, rumen structure and epithelial morphology were robust and rumen pH remained above 6.0…

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Alpha Fold Working

AlphaFold: The making of a scientific breakthrough The inside story of the DeepMind team of scientists and engineers who created AlphaFold, an AI system that is recognised as a solution to “protein folding”, a grand scientific challenge for more than 50…

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Tramadol Therapy and CYP2D6 Genotype – Medical Genetics Summaries

Introduction Tramadol (brand names ConZip, Ultram, UltramER, Odolo) is an analgesic used to treat moderate to severe pain. It is used for a variety of pain conditions, including post-operative pain, cancer pain, and musculoskeletal pain. Tramadol is a centrally acting opioid analgesic with mu-opioid binding activity as well as weak…

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KEGG COMPOUND: C07647

KEGG COMPOUND: C07647     COMPOUND: C07647 Help Entry C07647                      Compound                                Name Phosphoramide mustard;Phosphamide mustard Formula C4H11Cl2N2O2P Exact mass 219.9935 Mol weight 221.0221 Structure Mol fileKCF fileDB search Reaction Pathway map00982   Drug metabolism – cytochrome P450 Other DBs KCF data Show ATOM        11            1   N1c N    23.8758  -15.8550            2   P1a P    23.8642  -17.2548            3   C1b C    22.6627  -15.1552            4   C1b C    25.0830  -15.1611            5   N1a N    25.2698  -17.2548            6   O1c O    23.8583  -18.6603            7   O3b O    22.4645  -17.2548            8   C1b C    21.4497  -15.8550            9   C1b C    26.2963  -15.8610            10  X   Cl   20.2365  -15.1552            11  X   Cl   27.5093  -15.1728BOND        10            1     1   2 1            2     1   3…

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Phenotypic characterization and analysis of complete genomes of two distinct strains of the proposed species “L. swaminathanii”

Since 2010, there have been multiple new species added to the Listeria genus, many originally isolated from natural environments16. This paper describes the genotypic and phenotypic characterization of two new Listeria isolates obtained from soil samples collected in the Great Smoky Mountains National Park along the North Carolina-Tennessee border17. Evaluation…

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CYP2D6 antibody | Anti-CYP2D6 | stjohnslabs

Host: Goat Applications: Pep-ELISA, WB Reactivity: Human Note: FOR RESEARCH USE ONLY (RUO). Short Description: Goat polyclonal antibody anti-CYP2D6 (C-Term) is suitable for use in ELISA and Western Blot research applications. Clonality: Polyclonal Conjugation: Unconjugated Isotype: IgG Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine…

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Letter for the article Association Between Polypharmacy, Anxiety, and

Dear editor We have read with great interest the study by Cheng et al,1 which determined that older adult patients with polypharmacy were at greater risk of developing depression. We would like to share our perspectives based on our experience from an academic medical center hospital with 4000 beds in…

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Pharmacogenomics study clopidogrel by rflp based genotyping of cypc in cardiovascular disease

Volume 5 • Issue 3 • 1000132 J Pharmacogenomics Pharmacoproteomics ISSN: 2153-0645 JPP, an open access journal Research Article Open Access Prasanthi et al., J Pharmacogenomics Pharmacoproteomics 2014, 5:3 DOI: 10.4172/2153-0645.1000132 Research Article Open Access Pharmacogenomics Study of Clopidogrel by RFLP based Genotyping of CYP2C19 in Cardiovascular Disease Patients in…

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Antiplatelet response to clopidogrel is associated with a haplotype in CYP2C19 gene in Pakistani patients

Amsterdam, E. A. et al. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: Executive summary: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 130, 2354–2394 (2014). Google Scholar  Kernan, W. N. et al. Guidelines for the prevention…

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A hypoxia-related signature in lung squamous cell carcinoma

Introduction Lung cancer is the major leading cause of tumour-related deaths throughout the world, while lung squamous cell carcinoma (LUSC) as the second most common histological type of lung cancer.1 Each year, almost 1.8 million people are diagnosed with lung cancer worldwide and 400,000 of these die from LUSC.2,3 Due to…

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Delsym (Dextromethorphan) Oral: Uses, Side Effects, Dosages

What Is Delsym? Delsym (dextromethorphan) is an over-the-counter (OTC) cough syrup that is used often during cold and flu season to relieve cough.  Although Delsym has been available for a relatively long time, how it works is not completely known. However, medical experts believe that Delsym may work by mimicking…

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Comparative genomic analysis of vertebrate mitochondrial reveals a differential of rearrangements rate between taxonomic class

Pereira, S. L. Mitochondrial genome organization and vertebrate phylogenetics. Genet. Mol. Biol. 23, 745–752 (2000). CAS  Google Scholar  Boore, J. L. Animal mitochondrial genomes. Nucl. Acids Res. 27, 1767–1780 (1999). CAS  PubMed  PubMed Central  Google Scholar  Formenti, G. et al. Complete vertebrate mitogenomes reveal widespread gene duplications and repeats. BioRxiv…

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Self-electrochemiluminescence biosensor based on CRISPR/Cas12a and PdCuBP@luminol nanoemitter for highly sensitive detection of cytochrome c oxidase subunit III gene of acute kidney injury

Available online 22 March 2022, 114207 doi.org/10.1016/j.bios.2022.114207Get rights and content Abstract The cytochrome c oxidase subunit III (COX III) gene is a powerful biomarker for the early diagnosis of acute kidney injury. However, current methods for COX III gene detection are usually laborious and time-consuming, with limited sensitivity. Herein, we…

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Mitogenome of a stink worm (Annelida: Travisiidae) includes degenerate group II intron that is also found in five congeneric species

Tan, M. H. et al. Comparative mitogenomics of the Decapoda reveals evolutionary heterogeneity in architecture and composition. Sci. Rep. 9, 1–16 (2019). ADS  Google Scholar  Zhang, Y. et al. Phylogeny, evolution and mitochondrial gene order rearrangement in scale worms (Aphroditiformia, Annelida). Mol. Phylogenet. Evol. 125, 220–231 (2018). CAS  PubMed  Google…

Continue Reading Mitogenome of a stink worm (Annelida: Travisiidae) includes degenerate group II intron that is also found in five congeneric species

Gene Set – TFDP2

Symbol Name ACBD6 acyl-CoA binding domain containing 6 ACO2 aconitase 2, mitochondrial ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 AK2 adenylate kinase 2 ALDH6A1 aldehyde dehydrogenase 6 family, member A1 AP1S1 adaptor-related protein complex 1, sigma 1 subunit AP4M1 adaptor-related protein complex 4, mu 1 subunit APH1A APH1A…

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Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine.

Grozinger M, Dragicevic A, Hiemke C, Shams M, Muller MJ, Hartter S Melperone is an inhibitor of the CYP2D6 catalyzed O-demethylation of venlafaxine. Pharmacopsychiatry. 2003 Jan;36(1):3-6. doi: 10.1055/s-2003-38084. INTRODUCTION: Melperone, a butyrophenone neuroleptic, is frequently used for its sleep-inducing properties. Despite its common use for more than 30 years, it…

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are metabolised – Translation into Swedish – examples English

Dose reduction of medicinal products with a narrow therapeutic index that are metabolised by CYP2D6 should be considered. Dosreduktion av läkemedel med smalt terapeutiskt index som metaboliseras av CYP2D6 ska övervägas. Thus administration of ulipristal acetate is unlikely to alter the clearance of…

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Single-nucleus transcriptional profiling of chronic kidney disease after cisplatin nephrotoxicity

This article was originally published here Am J Pathol. 2022 Jan 26:S0002-9440(22)00013-X. doi: 10.1016/j.ajpath.2021.12.012. Online ahead of print. ABSTRACT Cisplatin induces both acute and chronic nephrotoxicity during chemotherapy in cancer patients. Here, we report the first study of single-nucleus sequencing (snRNA-seq) of cisplatin-induced nephrotoxicity. Repeated low-dose cisplatin treatment (RLDC) led…

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Avian mtDNA primers

Avian mtDNA Primers The PDF file below provides details on a complete set of primers for amplifying and sequencing avian mitochondrial DNA. All of the primers have been designed to work with most or all birds and most perform very well in this regard. The document is intended as a…

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The Genetic Architecture of Sleep Health Scores in the UK

Introduction Sleep is a complex neurological and physiological state. It is defined as a natural and reversible state of reduced responsiveness to external stimuli and relative inactivity, accompanied by a loss of consciousness.1 Sleep disorders can be classified as seven major categories: insomnia disorders, sleep-related breathing disorders, central disorders of…

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KEGG ORTHOLOGY: K11868

KEGG ORTHOLOGY: K11868     ORTHOLOGY: K11868 Help Entry K11868                      KO                                      Symbol CYP71A13 Name indoleacetaldoxime dehydratase [EC:4.8.1.3] Pathway Brite KEGG Orthology (KO) [BR:ko00001] 09100 Metabolism  09105 Amino acid metabolism   00380 Tryptophan metabolism    K11868  CYP71A13; indoleacetaldoxime dehydratase 09180 Brite Hierarchies  09181 Protein families: metabolism   00199 Cytochrome P450    K11868  CYP71A13; indoleacetaldoxime dehydrataseEnzymes [BR:ko01000] 4. Lyases  4.8  Nitrogen-oxygen lyases   4.8.1  Hydro-lyases    4.8.1.3  indoleacetaldoxime dehydratase     K11868  CYP71A13; indoleacetaldoxime dehydrataseCytochrome P450 [BR:ko00199] Cytochrome P450, plant type  CYP71 family   K11868  CYP71A13;…

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Genetic Polymorphisms in Xenobiotic Metabolism as Susceptibility Factors for Parkinson’s Disease | Research Project Database | Grantee Research Project | ORD

Genetic Polymorphisms in Xenobiotic Metabolism as Susceptibility Factors for Parkinson’s Disease EPA Grant Number: R827017 Title: Genetic Polymorphisms in Xenobiotic Metabolism as Susceptibility Factors for Parkinson’s Disease Investigators: Chan, Piu Institution: Parkinson’s Institute EPA Project Officer: Hahn, Intaek Project Period: October 1, 1998 through September 30,…

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Comparative de novo transcriptome analysis identifies salinity stress responsive genes and metabolic pathways in sugarcane and its wild relative Erianthus arundinaceus [Retzius] Jeswiet

1. Singh, A. et al. Phytochemical profile of sugarcane and its potential health aspects. Pharmacogn. Rev. 9, 45–54 (2015). CAS  PubMed  PubMed Central  Google Scholar  2. Eggleston, G. Positive aspects of cane sugar and sugar cane derived products in food and nutrition. J. Agric. Food Chem. 66, 4007–4012 (2018). CAS …

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KEGG ENZYME: 1.14.14.86

Entry EC 1.14.14.86               Enzyme                                  Name ent-kaurene monooxygenase;ent-kaurene oxidase (misleading) Class Oxidoreductases;Acting on paired donors, with incorporation or reduction of molecular oxygen;With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donorBRITE hierarchy Sysname ent-kaur-16-ene,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (hydroxylating) Reaction(IUBMB) ent-kaur-16-ene + 3 [reduced NADPH—hemoprotein…

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Very important pharmacogene variants in the Blang population

Introduction The use of drugs should be different among diverse ethnic groups because of differences in ethnicity, age, sex, environmental factors and genetic factors. If these differences are ignored, then drug sensitivity, metabolic rate, and adverse reactions are affected, which influences the curative effect of drugs and aggravates the illness…

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KEGG PATHWAY: Benzoxazinoid biosynthesis – Oryza sativa japonica (Japanese rice) (RefSeq)

KEGG PATHWAY: Benzoxazinoid biosynthesis – Oryza sativa japonica (Japanese rice) (RefSeq) [ | Pathway entry | Download KGML | Show description | Image (png) file | Help ] Benzoxazinoids (hydroxamic acids) are plant secondary metabolites that serve as important factors for host resistance against microbial pathogens and insects and for…

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Complete mitochondrial genome sequencing of Oxycarenus laetus (Hemiptera: Lygaeidae) from two geographically distinct regions of India

Genome organization and structure of O. laetus The MiSeq data of BTI and CBE samples of O. laetus was submitted to the NCBI SRA database under the accession numbers SRR11024516 and SRR11024517, respectively. The study was done to understand whether there exists a different species of the genus Oxycarenus similar…

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Presence of male mitochondria in somatic tissues and their functional importance at the whole animal level in the marine bivalve Arctica islandica

1. Karnkowska, A. et al. A eukaryote without a mitochondrial organelle. Curr. Biol. 26, 1274–1284 (2016). CAS  PubMed  Article  Google Scholar  2. John, U. et al. An aerobic eukaryotic parasite with functional mitochondria that likely lacks a mitochondrial genome. Sci. Adv. 5, 1–12 (2019). Article  CAS  Google Scholar  3. Breton,…

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KEGG REACTION: R08905

Entry RC00014                     RClass                                  Definition C5a-C6a:S2a+*-*+O6a:C1b+O5a-C1b+O6a Reactant pair Related class DB search Reaction Enzyme Pathway rn00020   Citrate cycle (TCA cycle) rn00072   Synthesis and degradation of ketone bodies rn00120   Primary bile acid biosynthesis rn00130   Ubiquinone and other terpenoid-quinone biosynthesis rn00280   Valine, leucine and isoleucine degradation rn00333   Prodigiosin biosynthesis rn00360   Phenylalanine metabolism rn00524   Neomycin,…

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Integrated bioinformatics analysis to identify abnormal CC

Introduction In recent years, the morbidity and mortality of colon cancer have increased rapidly, both being ranked fourth worldwide. Although surgery-based comprehensive treatments improve the prognosis of colon cancer, because of the lack of available means for early diagnosis, the mortality level remains high for patients with advanced-stage cancer. The…

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