Categories
Tag: DECIPHER
Community-scale models of microbiomes: Articulating metabolic modelling and metagenome sequencing
Review doi: 10.1111/1751-7915.14396. Online ahead of print. Affiliations Expand Affiliations 1 Quadram Institute Bioscience, Norwich, UK. 2 Earlham Institute, Norwich, UK. 3 Inria, University of Bordeaux, INRAE, Talence, France. 4 University of Bordeaux, CNRS, Bordeaux INP, LaBRI, UMR 5800, Talence, France. 5 INRAE STLO¸University of Rennes, Rennes, France. 6 INRAE,…
UC San Diego’s Bioengineering Team Uses TSCC at SDSC for Bioinformatics Tool
Jan. 19, 2024 — Over 18 million people worldwide are annually diagnosed with cancer, with each case hiding many mutations in its genome. Understanding these mutations furthers cancer research, while also providing a deeper understanding to create possible cures, therapies and prevention strategies. The Triton Shared Computer Cluster at the…
Researcher/Postdoc to enhance computational resources for regulatory genomics with deep learning
Description: The Computational Biology & Gene Regulation group led by Anthony Mathelier at the NCMM, a part of the Nordic EMBL Partnership for Molecular Medicine, is seeking a highly motivated Researcher or Postdoctoral Fellow for a two-year position, starting as soon as possible in 2024. The selected candidate will play…
The Science Behind It: Metagenomics 101
If microorganisms are invisible to the naked eye, how do we know anything about them? Generally, there are 3 common ways to identify microbes living in a given environment. The first is microscopy – looking at microbes under a microscope. There are only a few different shapes that microbes can…
Professor Jonathan Losos explains evolutionary biology using cats
Jonathan Losos, professor and director of the Living Earth Collaborative, spoke on “The Science of Cats and the Future of Nature” in a talk co-hosted by the Washington University Alumni Association and the College of Arts & Sciences on Dec. 11 in Wrighton Hall. Losos explained modern research on cats,…
Google’s newest AI Model, Gemini
Gemini introduces multimodal capabilities, greater accuracy and decreased bias, opening up a whole new wave of creative possibilities for companies. As Google’s largest AI model, Gemini reflects the company’s commitment to pushing the boundaries of innovation in AI. Its unique approach, using a single model to integrate multiple modalities, establishes…
How to land a scientific position even in a struggling economy
Scientists say they’re finding it increasingly difficult to find a new roles, but there are ways to boost the chances of job applications.Credit: Patrick T. Fallon/Bloomberg via Getty Challenging economic circumstances are affecting scientists’ job searches, with greater competition for limited posts. Nature’s first global survey of postdoctoral researchers revealed…
Highly dynamic inflammatory and excitability transcriptional profiles in hippocampal CA1 following status epilepticus
Dynamic mRNA signatures in the early phase of epileptogenesis after Pilocarpine-induced SE To decipher transcriptional changes early after pilocarpine-induced SE in the hippocampal CA1 subfield, we compared mRNA expression profiles of pilocarpine-induced SE animals and non-SE controls in hippocampal CA1 at five different time points, i.e. 6, 12, 24, 36…
Scientist (Postdoc) in the field of Bioinformatics/Artificial Intelligence, Leipzig, Sachsen
The Fraunhofer-Gesellschaft () currently operates 76 institutes and research institutions throughout Germany and is the world’s leading applied research organization. Around employees work with an annual research budget of 2.9 billion euros. Its Fraunhofer Institute for Cell Therapy and Immunology IZI researches and develops special problem solutions at the interfaces…
Analysis of geometric morphometrics and molecular phylogeny for Anopheles species in the Republic of Korea
World Health Organization (WHO). WHO malaria report. 2022 www.who.int/publications/i/item/9789240064898 (2022). Savi, M. K. An overview of malaria transmission mechanisms, control, and modeling. Med. Sci. 11, 3 (2023). Google Scholar Bahk, Y. Y. et al. Epidemiological characteristics of re-emerging vivax malaria in the Republic of Korea (1993–2017). Korean J. Parasitol. 56,…
AlphaFold: Illuminating the Blueprint of Life’s Building Blocks | by om varshney | Dec, 2023
Image sourced from 3D Tour of the Cell Proteins permeate every corner of our world. Indeed, the entirety of Earth’s organic composition emerges as a result of an intricate choreography involving roughly 200 million proteins. These proteins intricately interlace, giving rise to the myriad structures that underpin the creation of…
Support Specialist for Deicpher Project – EMBL-EBI
Support Specialist for Deicpher Project EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: Genome Assembly & AnnotationJob Number: EBI02203Contract Type: Staff MemberContract Duration-Is this renewable to 9 years?: if suficient funds renewedContract Duration-Length of Time (years/months): 2 years (Project based contract until May 2026)Advertised Grade-Grading: Grade 5 monthly…
Postdoctoral Researcher – image analysis/bioinformatics – Spatio-temporal genome and oncogene organization in cancer 80 -100 %
Sarcoma and Anesthetics Research Department, Balgrist University Hospital The Surdez lab at the University of Zurich is seeking a highly motivated Postdoctoral Researcher with expertise in image analysis and bioinformatics. This position offers an exciting opportunity to visualize and decipher the spatio-temporal organization of the genome and oncogenes in cancer….
Too many open files caused by persistent_workers and pin_memory – data
Having some trouble running PyTorch and Lightning with Optuna. After a few trials I run into the following error: OSError: [Errno 24] Too many open files I’ve assembled a script based on Optuna’s example of a PyTorch implementation that very consistently runs into this error on my machine. “”” Optuna…
Google launches Gemini, new AI model to compete with GPT-4
Thu Dec 7, 2023 12:52 PM Last update on: Thu Dec 7, 2023 05:11 PM Gemini, Google’s latest suite of AI models, has already been integrated to Google Bard, and will be implemented in Google Search and ad products soon. Image: Google “> Gemini, Google’s latest suite of AI models,…
Human hg38 chr6:31,165,200-31,165,800 UCSC Genome Browser v457
Custom Tracks ac4C-RIP-seq peaks, hESC CTL-1hidedensesquishpackfull ac4C-RIP-seq peaks, hESC CTL-2hidedensesquishpackfull ac4C-RIP-seq peaks, hESC NAT10-KD-1hidedensesquishpackfull ac4C-RIP-seq peaks, hESC NAT10-KD-2hidedensesquishpackfull Mapping and Sequencing Base Positionhidedensefull p14 Fix Patcheshidedensesquishpackfull p14 Alt Haplotypeshidedensesquishpackfull Assemblyhidedensesquishpackfull Centromereshidedensesquishpackfull Chromosome Bandhidedensesquishpackfull Clone Endshidedensesquishpackfull Exome Probesetshidedensesquishpackfull FISH Cloneshidedensesquishpackfull Gaphidedensesquishpackfull GC Percenthidedensefull GRC Contigshidedensefull GRC Incidenthidedensesquishpackfull Hg19…
DNA Sequencing Market Surges: Unraveling the Future
DNA Sequencing Market DNA Sequencing Market Report Scope: This report serves as a genetic roadmap, comprehensively examining the DNA Sequencing Market. From breakthrough technologies and market drivers to regional insights and future trends, the report sheds light on the expansive landscape of DNA sequencing. Stakeholders seeking to decipher the intricacies…
Unveiling the RNA-mediated allosteric activation discloses functional hotspots in CRISPR-Cas13a
doi: 10.1093/nar/gkad1127. Online ahead of print. Affiliations Expand Affiliations 1 Department of Bioengineering, University of California Riverside, Riverside, CA , 92521, USA. 2 Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA. 3 Center for RNA Biology, University of Rochester School of Medicine and…
MSL2 ensures biallelic gene expression in mammals
Materials Animals All of the mice were kept in the animal facility of the Max Planck Institute of Immunobiology and Epigenetics. The mice were maintained under specific-pathogen-free conditions, with 2 to 5 mice housed in individually ventilated cages (Techniplast). The cages were equipped with bedding material, nesting material, a paper…
The only way is Esox
Can you tell me a bit about your background? I was born in London, UK to an Irish mother and Canadian father. School holidays were spent in each country whereby I established my passion for fish, fishing and the aquatic world. Every day would be spent by the water: watching…
Bridge Informatics hiring Bioinformatics Engineer in Toronto, Ontario, Canada
Company Description At Bridge Informatics, we specialize in developing custom data-driven solutions for life science customers. Our mission is to bridge the gap between bench researchers and bioinformaticians, practice and theory, and data and insight to provide efficient, interdisciplinary solutions for our clients. Join our team and work on innovative…
A Trimodal Approach to Interrogate Breast Cancer
Sponsored content brought to you by Along with advances in single-cell sequencing and multiomic analysis, researchers are able to more precisely decode the stages of human cancers—from precursor to development of invasive cancer—to more accurately inform therapeutic approaches. With more than 2 million global cases of breast cancer diagnosed annually,…
QIAGEN hiring QDI Sales Specialist – Clinical Bioinformatics Services (EMEA and APEC) in United Kingdom
Position Description Joining QIAGEN Digital Insights (QDI) means embracing a dynamic realm of bioinformatics innovation. At the forefront of revolutionizing healthcare and life sciences, we pioneer cutting-edge solutions that decipher the complexities of biological data. Here, your career is a journey of constant learning, working with global experts, and contributing…
Nutrient found in beef and dairy improves immune response to cancer
Newswise — Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study by researchers from the University of Chicago. The…
The pros, cons and concerns
Commensurate with technological improvements and the subsequent rise in genetic research and genetics-based tests and treatments, the term ‘personalized medicine’ is being used more frequently. But what does it mean? This explainer outlines what personalized medicine is, its advantages and some concerns that have been raised in relation to it….
Next Generation Sequencing – Eppendorf New Zealand
NGS library preparation DNA sequencing is a method to decipher the base sequence in nucleic acids. The elucidation of the DNA sequence is essential for the understanding of virtually all biological processes e.g. human disease biology, inheritance, immunology, oncology, cellular biology. First generation sequencing devices use the capillary electrophoresis-based Sanger…
A DNA barcode library for woody plants in tropical and subtropical China
Hebert, P. D. N., Cywinska, A., Ball, S. L. & deWaard, J. R. Biological identifications through DNA barcodes. Proc Biol Sci 270, 313–321 (2003). Article CAS PubMed PubMed Central Google Scholar Huang, X., Ci, X., Conran, J. G. & Li, J. Application of DNA barcodes in Asian tropical trees –…
QIAGEN hiring QDI Bioinformatics Business Development Manager (EMEA) in United Kingdom
Position Description QIAGEN Digital Insights (QDI) is the division of QIAGEN focusing on bioinformatics and computational biology, offering a range of content assets, software solutions and services for the analysis and interpretation of biological data. Platforms, such as QIAGEN Clinical Insight (QCI) and QIAGEN Ingenuity Pathway Analysis (IPA), powered by…
AI Wrappers | tips for integration in data science
In the ever-evolving realm of AI, developers are constantly seeking tools that streamline integration, enhance functionality and make their lives a little less byte-some. In this comprehensive guide, we enter AI wrappers which help data scientists to foster seamless integration and enhanced capabilities into their projects. From the basics to…
Harris Lewin, leader of the Earth BioGenome P
To help mitigate the world’s biodiversity crisis, Arizona State University’s Julie Ann Wrigley Global Futures Laboratory has recruited Harris Lewin, a prominent genome scientist currently spearheading one of biology’s most ambitious ‘moonshot’ goals, a complete DNA catalog of the genetic code for life on Earth by the end of this decade. Lewin…
Earth BioGenome Project leader Harris Lewin joins ASU
November 15, 2023 To help mitigate the world biodiversity crisis, Arizona State University’s Julie Ann Wrigley Global Futures Laboratory has recruited Harris Lewin, a prominent genome scientist currently spearheading one of biology’s most ambitious moonshot goals — a complete DNA catalog of life’s genetic code by the end of this…
Reshaping AI With Mini Brains
Researcher & Professor at eCampus University Engineering Faculty. NASA Genelab AWG AI/ML member. Intellisystem Technologies Founder. getty AI researchers are exploring a promising “organoid intelligence” (OI) approach to develop more human-like intelligence. Researchers grow miniature brains from human stem cells to study brain development and neurological disorders. This emerging field…
Deciphering the data deluge: how large language models are transforming scientific data curation
Large language models are changing the way we carry out scientific data curation, annotation, and research, setting the stage for a more efficient understanding of scientific literature Credit: Karen Arnott/EMBL-EBI In a world inundated with data, curating valuable information has never been more challenging, or more important. From academic papers…
Genomics of soil depth niche partitioning in the Thaumarchaeota family Gagatemarchaeaceae
Sheridan, P. O. et al. Gene duplication drives genome expansion in a major lineage of Thaumarchaeota. Nat. Commun. 11, 1–12 (2020). Article Google Scholar Sheridan, P. O., Meng, Y., Williams, T. A. & Gubry-Rangin, C. Recovery of Lutacidiplasmatales archaeal order genomes suggests convergent evolution in Thermoplasmatota. Nat. Commun. 13, 1–13…
Unearthing Cures: Carleton Students Combat Antibiotic Resistance with Soil
Antibiotic resistance poses a significant global threat to health, food security, and development. As the effectiveness of antibiotics diminish, it is becoming increasingly challenging to treat infections like pneumonia, tuberculosis, and salmonellosis. This crisis not only results in extended hospital stays and higher medical expenses, it is also contributing to…
Evolutionary insights into 3D genome organization and epigenetic landscape of Vigna mungo
Introduction The non-random packaging of chromatin within the nucleus is a universal feature of eukaryotic genomes. The three-dimensional (3D) spatial organization of chromatin could be partitioned at different levels based on the interaction frequency between two given loci in the genome. Advances in sequencing technologies have led to the identification…
Biotech firm unveils precision medicine to revolutionise healthcare in UAE
Dr Anmol Kapoor and Dr Mariam Mattar at the launch of BioAro in the UAE. Sajjad Ahmad, Deputy Business Editor BioAro, the Canadian biotech powerhouse renowned for its groundbreaking strides in precision medicine, preventive healthcare, and personalised treatments, is embarking on a transformative journey into the heart of the United…
ASURAGEN TO PRESENT NOVEL CLINICAL TESTING DATA AT AMP 2023 CONFERENCE
Kitted assays for clinical laboratories streamline the detection of challenging genes and variants to improve results for underrepresented populations MINNEAPOLIS , Nov. 2, 2023 /PRNewswire/ — Bio-Techne Corporation (NASDAQ:TECH) today announced that Asuragen, a Bio-Techne brand, will present new data on clinical laboratory testing solutions related to cystic fibrosis variant detection, cancer…
New molecular insights on medical cannabis
A study explores some key biological mechanisms that help explain the therapeutic effects of medicinal cannabis on inflammation and other disease states. Here, researchers from the European Molecular Biology Laboratory outline their investigations into the effect of tetrahydrocannabinol (THC) on the enzyme Autotaxin. Autotaxin (ATX) is a 99-125 kDa lysophospholipase…
ftsj3 Summary
Gene Symbol: ftsj3 Gene Name: FtsJ RNA methyltransferase homolog 3 Synonyms: ( Nomenclature history ) Gene Function: Putative SAM-dependent rRNmethyltransferase SPB1 Protein Function : Probable…
Bioinformatics Specialist I | MGH Cancer Center
!*! GENERAL SUMMARY/ OVERVIEW STATEMENT: In Gulhan Lab, we develop statistical and machine learning methods for cancer genomics to improve patient classification and early cancer detection strategies. We aim to decipher the broad spectrum of genomic instabilities that dictate the evolution of cancer genomes, and to understand how best to…
DeepMind introduces AlphaFold 3, a groundbreaking AI model for drug discovery
TL;DR: DeepMind introduces AlphaFold 3, a groundbreaking AI model. AlphaFold 3 predicts the structures of most molecules in the Protein Data Bank. Isomorphic Labs applies AlphaFold 3 for drug discovery. The model also predicts ligand, nucleic acid, and post-translational modification structures. AlphaFold 3 eliminates the need for reference structures in…
Long-read sequencing to reclassify variants of uncertain significance in IRDs
(Image Credit: AdobeStock/XaMaps) Reviewed by Debarshi Mustafi, MD, PhD Long-read sequencing technology may be emerging as an option to streamline haplotype analysis in cases in which genetic testing of family members is unfeasible to provide a complete genetic diagnosis,1 according to Debarshi Mustafi, MD, PhD, senior author, from the Department…
AI at EMBL: enabling responsible innovations in the life sciences
EMBL stands as a leader, exemplifying how to harmoniously integrate AI in research and through its delivery of data services Ewan Birney, Deputy Director General of EMBL and Director of EMBL-EBI. Photo credit: Jeff Dowling/EMBL-EBI By Ewan Birney, Deputy Director General of EMBL and Director of EMBL’s European…
How to Write a Cover Letter for Bioinformatics Analyst Assistant
The cover letter for Bioinformatics Analyst Assistant, often considered a supplementary document in Bioinformatics Analyst Assistant Job applications, carries an intrinsic value. Enhance your job search strategy with tips from our How to Write a Cover Letter for Social Media Strategist Assistant Intern articles. It’s not just a customary practice…
Intersection of Chemistry & Technology to rewrite human Biological narrative for restoring Health
Time is right now to re-invent how we measure, analyse & interpret chemical reactions at molecular level using technology to eradicate chronic diseases Our Biology is unique, as distinctive as our fingerprint & at any given point in time, this hotbed of biochemical activities process tens of thousands of biological…
9 Popular Bioinformatics Careers – Institute for Career Studies
Education & Career Trends: October 19 Curated by the Knowledge Team of ICS Career GPS Bioinformatics offers multiple career opportunities for students and professionals passionate about biology and computer science. Excerpts are taken from an article published on graduate.northeastern.edu Bioinformatics is a multidisciplinary field combining statistics, biology, computer science, engineering, and…
The Next Generation of Microbial Quality Control
Thirty years ago, the Human Genome Project seemed like something straight out of a science fiction novel. Scientists were trying to decipher the chemical makeup of the human genetic code, the blueprints of life. This project aimed to sequence the entire length of human DNA, over 3 billion…
Become a Bioinformatics Pro: Easy Understanding Starts Here
Greetings Under the overarching framework of structural bioinformatics, a comprehensive understanding of basic proteomics is essential. Proteomics is the study of proteins on a large scale, encompassing their structure, function, and interactions within biological systems. Within this context, molecular docking plays a pivotal role. Molecular docking is a computational method…
BioSpace hiring Staff Bioinformatics Scientist – Machine Learning/Classifier Research and Development #2802 (Bay in Raleigh, NC
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale…
UK researchers call for urgent action to save unidentified plants
LONDON, United Kingdom – Millions of undescribed plants and fungi species may already be under threat from extinction, researchers at London’s Kew Gardens said on Tuesday, calling for urgent action to protect them. (Photo from AFP) At the sprawling Royal Botanic Gardens in the southwest of the British capital, teams are…
Studies show Decipher Prostate Genomic Classifier facilitates treatment decisions
Results from 2 studies shared during the 2023 ASTRO Annual Meeting showed that the Decipher Prostate Genomic Classifier—a 22-gene, whole-transcriptome profiling platform—facilitates treatment decisions for patients with prostate cancer.1 After nearly a decade of follow-up, cumulative distant metastasis was 27% vs 9% for patients with higher- vs low-risk Decipher scores,…
AI In Bioinformatics – How To Use AI In Bioinformatics
AI In Bioinformatics – How To Use AI In Bioinformatics In the exciting world of biology, Fernanda Garcia Fossa, a dedicated PhD student from Brazil, found herself facing a daunting challenge. She was studying nanotoxicology and needed to analyze countless images of human cells. But the process was painstakingly slow…
OBM Genetics | Whole Genome Sequencing in Era of Newborn Screening
Abstract After the completion of the human genome project, there have been many advances in the field of genetics. With next generation sequencing, patients can undergo genomic analysis through whole exome or whole genome testing. These comprehensive tests can shorten the diagnostic odyssey and guide medical management and thereby potentially…
Job Application for Senior Scientist, Bioinformatics at Flagship Pioneering, Inc.
Job Description – Senior Scientist, Bioinformatics About Harbinger Health Harbinger Health is pioneering the detection of early cancer and enabling foundationally new approaches to cancer screening, diagnosis, and management. Incubated within Flagship Pioneering for three years before launching in 2021, Harbinger combines advances in artificial intelligence with proprietary insights into…
New Data from Phase 3 Trial Further Validate Prognostic Value of Veracyte’s Decipher Prostate Genomic Classifier
Findings presented at the 2023 ASTRO Annual Meeting expand substantial body of evidence demonstrating Decipher Prostate test’s ability to help inform prostate cancer treatment decisions. Additional study suggests level of evidence supporting commercially available genomic classifiers should drive utilization. SOUTH SAN FRANCISCO, Calif., October 04, 2023–(BUSINESS WIRE)–Veracyte, Inc. (Nasdaq: VCYT)…
Senior Bioinformatics Scientist – DMPK
FULL_TIME Salary £48,000 – £65,000 per annum Location Oxfordshire FULL_TIME Consultant Miles Livingstone-Todd JobRef 50973743/001 Date posted 03 October 2023 south-east information-technology/development 2023-10-03 2023-12-02 science-and-research Oxford Oxfordshire GB GBP 48000 65000 65000 YEAR Robert Walters www.robertwalters.co.uk www.robertwalters.co.uk/content/dam/robert-walters/global/images/logos/web-logos/square-logo.png true ——————- Job Title: Senior Bioinformatics Scientist – DMPK Location: Oxford, UK (Hybrid)…
Filter, Plot, and Explore with Seurat in RStudio
First thing’s first, we need to load the packages we will be using. In order to use any functions of a package, we must first call the library of that package. In your console (likely in the lower left corner of your RStudio window), run the following lines of code…
Rancho Biosciences to Showcase Cutting-Edge Data Science Services at BioTechX Europe’s Largest Pharmaceutical Development and Healthcare Event, Oct. 4-6
SAN DIEGO, October 2, 2023 (Newswire.com) – Rancho Biosciences, the premier Data Science Services company headquartered in San Diego, California, is thrilled to announce its participation in Europe’s largest biotechnology congress, BioTechX, a pivotal event that serves as a bridge between pharmaceutical companies, academia, and clinicians. The event aims to…
How Does The Molecular Clock Work?
What is the molecular clock? The molecular clock is a concept used in evolutionary biology to estimate the timing of divergent events based on genetic differences between species. It suggests that the rate at which genetic mutations accumulate in organisms is relatively constant over time. These mutations occur in the…
Purpose, Types, Applications, Bioinformatics and more
Next-Generation Sequencing (NGS), also known as high-throughput sequencing, is a revolutionary technology used for determining the sequence of DNA or RNA molecules. It has significantly advanced the field of genomics and has numerous applications in various biological and medical fields. Key Points of Next-Generation Sequencing (NGS): Revolutionary Technology: NGS represents…
A tool to automatically design multiplex PCR primer pairs for specific targets using diverse templates
PMPrimer software PMPrimer is a Python-based tool for the automated design and evaluation of multiplex PCR primer pairs for specific targets using diverse templates (Fig. 1). To satisfy the need for automation, PMPrimer can directly extract taxonomic information at three levels of classification (genus, species, and subspecies) from input data in…
Blood, the new red gold of regenerative medicine? -Kaya Alana
0 Regenerative medicine has perhaps found the necessary vein for it to finally be complete and viable in the long term. A vein of red gold that could revolutionize the medicine of tomorrow. For those who are wondering what regenerative medicine and “red gold” are, I will come to that…
NVIGEN Pioneers Breakthrough in High-Resolution Tissue RNA Sequencing with Magnetic Nanoparticle Capture from Nanopipetting Aspiration of Minuscule Single Cell Contents
SANTA CLARA, Calif., Sept. 26, 2023 /PRNewswire/ — NVIGEN, a leading provider of modern nanoparticle solutions to empower revolutionary personalized healthcare, announces its new application in RNA sequencing (RNAseq) that promises to transform our understanding of cellular dynamics within tissues. Single-cell transcriptomics have opened new frontiers in…
How-to: Profile the epigenome
The epigenome regulates the expression of genes without altering their underlying DNA sequence. Comprising a dynamic landscape of chemical modifications and structural changes to DNA and its associated histone proteins, the epigenome wields profound influence over cellular identity and function. Epigenetic mechanisms, such as DNA methylation and histone modifications, form…
A Journey to Sustainable Growth in 2030
Our Global Irreversible Electroporation Ablators Market report provides invaluable insights into the size, growth, trends, and potential of the global GIS software market. It provides up-to-date market information on the various geographical regions within the global GIS software market and details the market share of the top vendors in the…
ncRNA | Free Full-Text | Discovery and Comprehensive Characterization of Novel Circular RNAs of the Apoptosis-Related BOK Gene in Human Ovarian and Prostate Cancer Cells, Using Nanopore Sequencing
1. Introduction Cancers of the reproductive organs, including human ovarian and prostate cancer, account for a big percentage of cancer morbidity and mortality worldwide, while their incidences have gradually increased in many countries [1]. According to the American Cancer Society, an estimated 268,490 men and 19,880 women were diagnosed with…
China’s Quest for Human Genetic Data Spurs Fears of a DNA Arms Race
In 2020 Serbian scientists were gifted China’s “Fire-Eye” labs, remembers the Washington Post. The sophisticated portable labs “excelled not only at cracking the genetic code for viruses, but also for humans, with machines that can decipher genetic instructions contained within the cells of every person on Earth, according to its…
Report: China scooped up human DNA from nations around the world
In the year 2020, during the COVID-19 pandemic when many European countries were under lockdown, an aircraft transported a Chinese creation known as the Fire-Eye to the Serbian capital. The Fire-Eye was a sophisticated portable laboratory designed to detect coronavirus infections by analyzing the genetic elements left behind by the…
Mysterious Circular RNA Linked to Alzheimer’s and Parkinson’s Diseases
Mysterious Circular RNA Linked to Alzheimer’s and Parkinson’s Diseases Scientists Uncover Mysterious Circular RNA Linked to Alzheimer’s and Parkinson’s Diseases Researchers have gained new insights into the largely overlooked world of circular RNA (circRNA) in brain cells and its crucial role in diseases like Alzheimer’s and Parkinson’s. In addition…
Diagnostic genome sequencing improves diagnostic yield: a prospective single-centre study in 1000 patients with inherited eye diseases
Introduction Although protein-coding regions represent only 1–2% of the human genome, they harbour an estimated 85% of annotated pathogenic variants.1 2 Despite these numbers, genome sequencing (GS) usually achieves a higher diagnostic yield than sequencing approaches that focus on exonic regions, not least because of its more homogeneous coverage3 4…
Covid helped China secure the DNA of millions, spurring arms race fears
BELGRADE — Most of Europe was in lockdown in April 2020 when a plane arrived in the Serbian capital bearing a well-timed gift from the People’s Republic of China. Inside was a Chinese invention called the Fire-Eye, a sophisticated portable lab that could detect coronavirus infections from tiny genetic fragments…
Piet Borst Wins a Lasker Award for Scientific Excellence
Today (September 21), the Lasker Foundation announced the recipients of the 2023 Lasker Awards. Sometimes referred to as “America’s Nobels,” these prestigious awards recognize fundamental biological discoveries, clinical advances, and public advocacy for science. Piet Borst, a physician-biochemist and molecular biologist at Netherlands Cancer Institute, received the Lasker~Koshland Award for…
Resurrecting the Tasmanian Tiger using RNA sequencing can help bring extinct species back to life
Thanks to advances in genome sequencing technologies, scientists are a step closer to resurrecting an extinct Tiger species called the Tasmanian Tiger. It was found on the Australian continent before it vanished from the face of Earth after European colonizers swept the indigenous population from their native lands. The efforts…
60 Years in the Making: AlphaFold’s Historical Breakthrough in Protein Structure Prediction
It had only been a few days since the world shook with news of a scientific triumph in protein structure prediction. Word had spread about an insurmountable biological puzzle that had tormented scientists for decades, and lo and behold, they cracked it. The hot topic on everyone’s lips was protein…
In a first, RNA is recovered from extinct Tasmanian tiger | WKZO | Everything Kalamazoo
By Will Dunham (Reuters) – The Tasmanian tiger, a dog-sized striped carnivorous marsupial also called the thylacine, once roamed the Australian continent and adjacent islands, an apex predator that hunted kangaroos and other prey. Because of humans, the species is now extinct. But that does not mean scientists have stopped…
Human Genomics Team Leader at European Molecular Biology Laboratory (EMBL)
About the team/job Recent advances in technology and analysis have revealed significant opportunities to further our understanding of the diversity and impact of human genetics (such as the first full length telomere-to-telomere human genome and the first release of the human pangenome). As a result, we are excited to launch…
In a first, RNA is recovered from extinct Tasmanian tiger
Three views of the desiccated remains of an extinct marsupial mammal called the Tasmanian tiger, or the thylacine, from a collection at the Swedish Museum of Natural History in Stockholm are seen in this undated handout image. Emilio Marmol Sanchez/Handout via REUTERS Acquire Licensing Rights Sept 19 (Reuters) – The…
The Role of AI in Genome Sequencing and Assembly
The Importance of AI in Genome Sequencing and Assembly Assembling Life’s Blueprint: The Role of AI in Genome Sequencing and Assembly Genome sequencing and assembly have revolutionized the field of biology, enabling scientists to unravel the mysteries of life encoded in our DNA. The ability to decipher the complete set…
Staff Bioinformatics Scientist – Machine Learning/Classifier Research and Development #2802 (Bay Area) at GRAIL – Menlo Park, CA
GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on alleviating the global burden of cancer by developing pioneering technology to detect and identify multiple deadly cancer types early. The company is using the power of next-generation sequencing, population-scale…
17 Intriguing Facts About Next-Generation Sequencing (Ngs)
Next-Generation Sequencing Revolutionized DNA Analysis Next-Generation Sequencing (NGS), also known as high-throughput sequencing, has transformed the field of genomics by enabling rapid and cost-effective DNA analysis. NGS Can Generate Massive Amounts of Genetic Data With its ability to simultaneously sequence millions of DNA fragments, NGS can generate vast amounts of…
Postdoctoral Fellow – Mechanisms of Assemblies Formation Essential to Muscle Function at European Molecular Biology Laboratory (EMBL)
About the team/job EMBL Grenoble specializes in fundamental research in structural biology, and in developing state-of-the art instrumentation, methods and services. The site is located on the dynamic European Photon and Neutron science campus (EPN campus), together with other international and French research institutions. We are recruiting a highly motivated…
Florida Museum researcher advances to finals
image: Team Waponi is made up of researchers and professionals with various backgrounds, including robotics experts who delivered and retrieved the Limelights and took leaf samples from the canopy using drones. view more Credit: Team Waponi, XPRIZE Over the course of four weeks this summer, a motley crew of biologists, engineers,…
DNA Sequencing Technologies Market 2023: Comprehensive Analysis on Emerging Technologies, Leading Players, and Future Growth Prospects
The “DNA Sequencing Technologies Market“ Research Report 2023: incorporates a thorough qualitative and quantitative analysis along with several market dynamics. Global DNA Sequencing Technologies Market size was valued at USD million in 2021, and poised to rise at an impressive growth rate of USD million by 2028 as projected. The…
Bayer Is Rapidly Expanding Its Footprint With Artificial Intelligence
Bayer is one of the world’s most prominent pharmaceutical and biotechnology companies. It is known for creating household staples such as Aspirin, to more advanced technologies and innovations that are often used behind the scenes, including dyes for radiological studies and critical crop/plant bio-products. The company is nearly 150 years…
The Gene Sequencing market’s size, dynamics, and anticipated development from 2023 to 2030 are thoroughly analyzed in this report, with a projected CAGR of 8.5%.
The report provides actual figures about the “Gene Sequencing Market” and the challenges within the industry. The market size can help businesses understand in better detail the overall growth and downfall of the Market. The Gene Sequencing market is expected to grow annually by 8.5% (CAGR 2023 – 2030). Gene…
TimeTalk uses single-cell RNA-seq datasets to decipher cell-cell communication during early embryo development
Curation of early-embryo development single-cell RNA-seq data sets for studying cell-cell communication To identify and study eLRs, we collected public early embryo development scRNA-seq datasets from the mouse MII-oocyte stage to the late blastocyst stage to ensure that scRNA-seq datasets represented every stage of early embryo development. In addition, to…
Sanger Sequencing Service Market Forecast 2023: Business Growth Drivers, Top Market Leaders, and Strategic Insights to 2030
The “Sanger Sequencing Service Market“ Research Report 2023: incorporates a thorough qualitative and quantitative analysis along with several market dynamics. Global Sanger Sequencing Service Market size was valued at USD 286 million in 2022, and poised to rise at an impressive growth rate of USD 458.9 million by 2027 as…
Global study decodes male sex chromosome for first time
The male sex chromosome has finally been decoded in a breakthrough that will help illuminate why some men are afflicted with certain conditions – and provide new hope for future treatments. While women carry XX sex chromosomes, men have XY, with mutations in the Y chromosome thought to be driving…
Scientists Unveil the First Complete Sequence of the Y Chromosome
After over two decades, the human genome sequence is finally complete. The holdout? The Y chromosome. Although far smaller than the other 23 chromosomes, Y is a genetic contortionist, carrying multiple strange structures that are notoriously difficult to disentangle, and not for lack of effort. As one of the two…
Scientists Determine the Y Chromosome Sequence for the First Time
The X and Y chromosomes, known as the sex chromosomes, determine an individual’s biological sex – Photo by Jonathan Bailey, National Human Genome Research Institute, National Institutes of Health Scientists have taken an important step toward understanding the human genome by deciphering the mysterious Y chromosome found in men, a…
Explained | Scientists finally decipher enigmatic Y chromosome, feat to help study male infertility
In a significant achievement set to redefine the realm of human biology, scientists have successfully sequenced the Y chromosome for the first time. The breakthrough translates into the unearthing of valuable information about human genetic material that could revolutionise the study of male infertility and various health disorders. Initial attempts…
The Male Y Chromosome Has Finally Been Completely Sequenced
Image by Getty / Futurism The human Y chromosome, the determinant of male sex, has finally been completely sequenced. What it unveils could prove crucial to understanding the Y chromosome’s puzzling origins, and — pertinently — how it affects male fertility. You can thank two teams of researchers for the breakthrough,…
Scientists Fully Sequence Y Chromosome for the First Time In Major Men’s Health Breakthrough
For the first time, scientists have fully sequenced a Y chromosome. Scientists say that this advancement could have great implications for the future of men’s health and offer insights into health problems like infertility. An international group of 100 scientists called the Telomere-to-Telomere Consortium came together last year looking to…
Translation dysregulation in neurodegenerative diseases: a focus on ALS | Molecular Neurodegeneration
Tandan R, Bradley WG. Amyotrophic lateral sclerosis: part 1. Clinical features, pathology, and ethical issues in management. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society. 1985;18:271–80. Article CAS Google Scholar Mehta P et al. Prevalence of amyotrophic lateral sclerosis (ALS), United States, 2016….
The Human Y Chromosome Has Just Been Sequenced For The Very First Time
It’s among the smallest of human chromosomes, but the complex structure of the Y chromosome has made it notoriously resistant to efforts to fully decipher it. Now, the first-ever complete sequence of the Y chromosome has been revealed, bringing us one step closer to solving a plethora of unanswered questions….
Cfdna-Top Ten Things You Need To Know.
Cfdna, an abbreviation for “cell-free DNA,” emerges as a groundbreaking phenomenon that has reshaped the landscape of medical diagnostics and our understanding of genetic material. In the intricate mosaic of biological entities, Cfdna stands as a unique entity – genetic fragments floating freely in bodily fluids, harboring a treasure trove…
The Role of DNA Synthesis in Next-Generation Sequencing Technologies
DNA, the molecule that carries the genetic instructions for all living organisms, has always been a fascinating subject for scientists. With the advent of modern technology, the ability to read these genetic instructions, a process known as sequencing, has become increasingly accessible and efficient. Understanding DNA Synthesis The process of…
What is the next step in preventative therapi
image: In a chronic inflammatory context, epigenetic changes occur in LPCs: (1) through a sustained stimulation by cytokines that either promotes dedifferentiation and transformation of LPCs to CSCs (IL-17, TNF-α and IL-6), or in contrast avoiding their transformation (IFN-γ, IL-27); (2) by hosting small non-coding RNAs transferred by exosomes coming from…
A tool for rapid, automated characterization of population epigenomics in plants
Creation and sequencing of epigenetically diverse plant populations To induce epigenetic variation, A. thaliana seeds were treated with three different concentrations of zebularine. We will describe these three different zebularine concentration groups, and our water and DMSO controls as “populations” throughout the remainder of this paper. Plants displayed stunted vegetative…