Tag: diagnostic

The Evolution from HG19 to HG38

Welcome to another blog post! ‍ Reference genomes are essential benchmarks of a species’ genome that facilitate the accurate comparison of individual genomes and are crucial tools for identifying genetic variants and diagnosing rare diseases. Here, we will explore the evolution of the human reference genome, focusing on the transition…

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Bioinformatics Market Is Set To Reach USD 28.6 Billion By 2030 With CAGR Of 13.73% | Marketdigits

(MENAFN– GlobeNewsWire – Nasdaq) The Global Bioinformatics Market was valued USD 10.23 Billion in 2023 and projected to reach USD 28.6 Billion by 2030, growing at a CAGR of 13.73% during the forecast period of 2023-2030 Richmond, Feb. 09, 2024 (GLOBE NEWSWIRE) — According to a research report ” Bioinformatics…

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CRISPR/Cas9 are the Most Sought Genome Editing Tools

Company Logo Global Genome Editing Market Global Genome Editing Market Dublin, Feb. 09, 2024 (GLOBE NEWSWIRE) — The “Global Genome Editing Market, 2023-2035: Focus on Technology, Industry Trends and Forecasts” report has been added to ResearchAndMarkets.com‘s offering. The global genome editing market size for technologies is estimated to be worth…

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Use of CD32, CD44 and CD71 to differentiate follicular lymphoma and diffuse large B-cell lymphoma subtypes by flow cytometry

Many lymphomas can be immunophenotyped by flow cytometry (FCM), providing valuable diagnostic information.1 However, FCM cannot typically be used to distinguish follicular lymphoma (FL), diffuse large B-cell lymphoma, germinal centre type (DLBCL-GCB) and diffuse large B-cell lymphoma, non-germinal centre type (DLBCL-nGCB). To expand the utility of clinical FCM, we compared…

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Bioinformatics Market is Set to Reach USD 28.6 Billion by

Richmond, Feb. 09, 2024 (GLOBE NEWSWIRE) — According to a research report “Bioinformatics Market”, by tools Type (BLAST, BioPerl, InterMine, Others), Services (Genome Sequencing, RNA sequencing, Metagenomic Analysis, Epigenomic, Others), Application (Drug discovery, Personalized medicine, Preventive medicine, Transcriptions, Metabolomics, Gene therapy, Others) Sectors (Medical Biotechnology, Animal Biotechnology, Plant Biotechnology, Environmental…

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Danaher Jobs – Principal Bioinformatics Scientist

At Cepheid, we are passionate about improving health care through fast, accurate diagnostic testing. Our mission drives us, every moment of every day, as we develop scalable, groundbreaking solutions to solve the world’s most complex health challenges. Our associates are involved in every stage of molecular diagnostics, from ideation to…

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Shedding Light on BIA-ALCL Risks

In a society that celebrates individuality and self-expression, the journey to aesthetics takes many forms. One such road, taken by countless women seeking empowerment and confidence, is breast augmentation. This blog dives deep into the dark and flip side of breast augmentation- Allergan breast implant lawsuits. Before answering the query…

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5 hot biotechnology careers skyrocketing in demand

With many exciting discoveries to make and new problems to solve, the biotechnology industry provides many career opportunities that could make a difference in people’s lives. So, if you are searching for a career in the field, we have listed five biotechnology careers that are currently in high demand, and…

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New RNA interference therapy shows promise in reducing high blood pressure

About 1.3 billion adults worldwide have clinically high blood pressure, many of whom may , [+] Unaware that they are living in this situation. getty Approximately 1.3 billion adults worldwide have clinically high blood pressure, many of whom may be unaware that they are living with the condition. As a…

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Interventional Tumor Ablation Market by Share, Trends, Growth Factors, Developments, Product Innovation and Forecast till 2032 | Taiwan News

Report Ocean published a new report, titled, “Interventional Tumor Ablation Market 2023-2032“. The report has offered an all-inclusive analysis of the global market taking into consideration all the crucial aspects like growth factors, constraints, market developments, top investment pockets, future prospects, and trends. At the start, the report lays emphasis…

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Monthly Salary Up to 56000, Check Post, Tenure, Age Limit and Interview Details

AIIMS Kalyani Recruitment 2024: Monthly Salary Up to 56000, Check Post, Tenure, Age Limit and Interview Details AIIMS Kalyani Recruitment 2024: The All India Institute of Medical Sciences (AIIMS) Kalyani recruitment drive is being conducted to fill 03 vacancies of Project Research Scientist -I (Non-Medical) and Project Technical Support-I (Medical…

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Helio Genomics Collaborates with University of California, Irvine, to Study Effectiveness of Multimodal Epigenetic Sequencing for Enhancing Early Cancer Detection

Findings published in open-access journal Genome Medicine. IRVINE, Calif., Jan. 18, 2024 /PRNewswire/ — Helio Genomics, an AI-driven healthcare company specializing in diagnostics technology and test development for cancer detection, today announced that results from an important new research study have been published in the peer-reviewed journal, Genome…

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Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice

Background: IgE has been known for mediating endothelial cell dysfunction and mast cell (MC) activation to fuel asthma-aggravated high-fat diet-induced atherosclerosis. However, it remains unclear for the mechanism of asthma-mediated atherosclerosis, especially the potential involvement of IgE in the exacerbation of asthma-mediated atherosclerosis with a standard laboratory diet, and the…

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FDA Approves Balversa for Locally Advanced, Metastatic Urothelial Carcinoma

Image credit: Matthieu | stock.adobe.com The FDA has approved Balversa (erdafitinib) for adults with locally advanced or metastatic urothelial carcinoma with susceptible FGFR3 genetic mutations whose disease progressed on or following one line of systemic therapy.1 The regulatory action amends the accelerated approval granted by the FDA in April 2019 for patients…

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Genomic insights into Plasmodium vivax population structure and diversity in central Africa | Malaria Journal

Hamblin MT, Di Rienzo A. Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus. Am J Hum Genet. 2000;66:1669–79. Article  CAS  PubMed  PubMed Central  Google Scholar  Hamblin MT, Thompson EE, Di Rienzo A. Complex signatures of natural selection at the Duffy blood group…

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The Role of Nanoparticles in Cancer Therapy: Advancements in Nanotechnology

With the advent and advancements in nanotechnology, the field of cancer therapy is witnessing a paradigm shift. Nanoparticles, owing to their unique properties, are proving to be promising carriers for drug delivery in cancer therapy. The study scrutinizes the transport of nanoparticles in two abnormal microenvironments through a 2-D simulation…

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Improving sensitivity and success of liquid c

Intravenous nanoparticle priming agents given hours before a blood draw greatly increase the sensitivity to liquid biopsies for detecting cancer, according to a preclinical study in mice. In these animals, the approach increased the sensitivity for detection of small tumors from 10% to 75%. “Just as iodinated and gadolinium contrast…

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Could natural killer cells revolutionize Alzheimer’s treatment?

This week on the podcast, we have a conversation with Dr Paul Song, CEO of NKGen Biotech, a company with its sights set on changing the Alzheimer’s disease treatment landscape with natural killer cells. The company’s natural killer (NK) cell Alzheimer’s treatment uses a patient’s cells, collected by a simple…

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Inotrem Successfully Reaches Agreement with the FDA for a Phase 3 Registration Trial for Nangibotide in Septic Shock

Novel biomarker-guided Phase 3 registration trial in septic shock with an enrichment strategy-based patient selection. Historic paradigm shift in Primary endpoint: from all causes of mortality at Day 29 to proportion of patients alive and free of organ support at Day 29. PARIS, January 08, 2024–(BUSINESS WIRE)–Inotrem, an advanced clinical…

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Domestic pigs are susceptible to experimental infection with non-human primate-derived Reston virus without the need for adaptation

Ethics and animal welfare statement All infectious work with RESTV, including sample inactivation, was performed in the Containment Level 4 laboratory (CL4) in accordance with the policies and protocols outlined by the Canadian Science Centre for Human and Animal Health Institutional Biosafety Committee. All animal work was performed in strict…

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Study sheds more light into benefits of immunotherapy

According to the Brigham researchers’ next-generation sequencing, changing existing cancer care standards might allow around 6,000 more patients in the United States to benefit from immunotherapy treatment each year. Immunotherapy is a highly successful treatment for cancer patients with mismatch repair failure, and new research finds additional cancer patients…

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Understanding DNA Sequence Alignment using C++ Code | by Shriya Paturu | Dec, 2023

Introduction: DNA sequence alignment is a fundamental technique in bioinformatics used to compare and analyze genetic sequences. In this article, we’ll explore a C++ implementation of a basic DNA sequence alignment algorithm, shedding light on its significance and applications in biological research. Background: DNA sequencing is a technique used to…

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Pulmonary Fibrosis Biomarkers Market Soars to a Valuation of US$ 6.2 Billion by 2033-FMI Study

Pulmonary Fibrosis Biomarkers Market With a projected market size of US$ 4.1 billion in 2023 and an expected CAGR of 4.2% over the forecast period, the global pulmonary fibrosis biomarkers market size is expected to develop significantly, reaching a worth of US$ 6.2 billion by 2033. Key to this growth…

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Robotic D3 Partial Duodenal Resection with Primary Side-to-Side Anastomosis

This protocol presents a case of a robotic partial duodenal resection with primary side-to-side duodeno-jejunal reconstruction in a patient with a 5 cm duodenal stenosis. This is done at the third duodenal segment (D3) after an endoscopic mucosal resection (EMR) for a duodenal polyp. This video demonstrates all steps of…

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Identifying Prognostic Genes in Diffuse Large B-cell Lymphoma (DLBCL)

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, a cancer that starts in cells called lymphocytes, which are part of the body’s immune system. Its progression and prognosis vary significantly among patients, making it crucial to identify prognostic factors that can help predict patient outcomes…

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Development and evaluation of a CRISPR-Cas13a system-based diagnostic for hepatitis E virus

Objectives: Hepatitis E virus (HEV) is the leading cause of acute viral hepatitis worldwide. HEV RNA detection is the gold standard for HEV infection diagnosis and PCR methods are commonly used but are usually time-consuming and expensive, resulting in low detection efficiency and coverage, especially in low-income areas. Here, we…

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Anti-EpCAM (Extracellular region) Antibody | Scientist.com

Anti-EpCAM (Extracellular region) Antibody | Scientist.com Skip to Main Content Go to Main Navigation Form: Protein G Purified Gene: EPCAM Host: Mouse Rrid: AB_3068418 Type: Primary Antibody Clone: M039 Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol Target: EpCAM (Extracellular region) Isotype: IgG1 Storage: Storage at -20°C…

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Help Fight Cancer with a Radiology Technologist Job

Radiology technologists play a vital role in cancer care. Also known as radiographers, these medical specialists perform important imaging tests on patients to create detailed images of targeted areas of the body. The images are then interpreted by a physician, who may use the results to help detect and diagnose…

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The top biotech breakthroughs that defined 2023

As we look back at 2023 it is clear that the year has been marked by steady progress and notable breackthroughts in the biotech industry. From advancements in Alzheimer’s disease treatments to new approaches in cancer therapy, artificial intelligence (AI) progression, and obesity management, this year has seen important steps…

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Diffuse Large B-Cell Lymphoma (DLBCL) Probe Panel by FISH – Laboratory Test Catalog

Test Name Alias DLBCL by FISH | Double Hit Lymphoma by FISH | Triple Hit Lymphoma by FISH | 9223 Interface Order Alias 11604 Clinical Information This probe panel detects specific structural chromosome abnormalities commonly associated with Diffuse Large B-cell Lymphoma.   Routine chromosome analysis is performed on all diagnostic…

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Genetic Testing Market Size Is Surpassing USD 44.3 Billion by 2032, Growing at Projected 9.8% CAGR

The Brainy Insights Global genetic testing market size from USD 17.4 billion in 2022 to USD 44.3 billion in 10 years. The rising prevalence of genetic diseases drives the market’s growth. Well-established healthcare system and the government’s provision of research funding are further elements expected to support market expansion. Newark,…

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De novo variants underlying monogenic syndromes with intellectual disability in a neurodevelopmental cohort from India

Russell PSS, Nagaraj S, Vengadavaradan A, Russell S, Mammen PM, Shankar SR, et al. Prevalence of intellectual disability in India: a meta-analysis. World J Clin Pediatr. 2022;11:206–14. Article  PubMed  PubMed Central  Google Scholar  Winnepenninckx B, Rooms L, Kooy RF. Mental retardation: a review of the genetic causes. Br J Dev…

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Seroprevalence and Molecular Characterization of B. abortus

Introduction Brucellosis is a zoonotic disease caused by Brucella spp., a gram-negative facultative intracellular coccobacillus.1 These microorganisms can infect livestock, wildlife, and humans, causing significant public concern and substantial agricultural economic loss. Currently, at least six novel Brucella species have been identified: Brucella pinnipedialis, Brucella ceti,2 Brucella papionis,3 Brucella microti,4…

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LncRNA/circRNA-mRNA networks in CARAS | JIR

Introduction Combined allergic rhinitis and asthma syndrome (CARAS), a new terminology introduced by the World Allergy Organization (WAO) in 2004, is an allergic reaction that occurs in the respiratory tract, including upper respiratory tract allergy (allergic rhinitis, AR) and lower respiratory tract allergy (asthma, AS).1,2 The incidence of AS in…

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The clinical utility of Nanopore 16S rRNA gene sequencing for direct bacterial identification in normally sterile body fluids

1Hong Kong Polytechnic University, Hong Kong, SAR China 2Pamela Youde Nethersole Eastern Hospital, China 3Prince of Wales Hospital, China 4Princess Margaret Hospital, Hong Kong, SAR China 5Tuen Mun Hospital, Hong Kong, SAR China The final, formatted version of…

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Analysis of sepsis combined with pulmonary infection by mNGS

Introduction Sepsis is one of the major diseases that poses a serious threat to human health, and its incidence and in-hospital mortality rates remain high despite the continuous updating of sepsis guidelines.1 Its main clinical manifestations are elevated body temperature, chills, and rapid heart rate, and it is most common…

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Plasma cell-free DNA 5-hydroxymethylcytosine and whole-genome sequencing signatures for early detection of esophageal cancer

Waters JK, Reznik SI. Update on management of squamous cell esophageal cancer. Curr Oncol Rep. 2022;24:375–85. Article  PubMed  Google Scholar  Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185…

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A prospective study clarifies the role of an innovative metagenomic tool

Characteristics of samples analyzed by mNGS(A) Distribution of sample types among the 742 samples analyzed by mNGS in the present study. (B) Distribution of the sample origins in the tissue category. (C) Distribution of the sample origins in the fluid category. CSF=cerebrospinal fluid. FFPE=formalin-fixed paraffin-embedded. BMA=bone marrow aspiration. URT=upper respiratory…

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Improving the diagnosis of infection: a prosp

Scientists from Necker-Enfants Malades Hospital (AP-HP), the Institut Pasteur, Université Paris Cité, Inserm, Université Paris-Est Créteil and the Alfort National Veterinary School, coordinated by Professor Marc Eloit and Dr. Anne Jamet in collaboration with Dr. Jacques Fourgeaud and Beatrice Regnault, studied the role of global genetic characterization of samples (or…

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Analysis of biomarkers in speculative CNS-enriched extracellular vesicles for parkinsonian disorders: a comprehensive systematic review and diagnostic meta-analysis

44. Zurück zum Zitat Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C, Bedina Zavec A, Benmoussa A, Berardi…

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Illumina Gives Up Fight With Regulators, Will Divest GRAIL

Key Takeways Illumina Inc. decided to end its controversial purchase of GRAIL, and will divest itself of the cancer diagnostic test maker. The deal ran into opposition from regulators in the U.S. and Europe when the DNA sequencing company closed on the GRAIL transaction before receiving approval. Activist investor Carl…

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First Wave BioPharma (FWBI) Enters Term Sheet for Merger with ImmunogenX

First Wave BioPharma, Inc., (NASDAQ: FWBI), (“First Wave BioPharma” or the “Company”), a clinical-stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for gastrointestinal (GI) diseases, today announced that the company has signed a non-binding term sheet for a business combination with ImmunogenX, a clinical-stage biotherapeutics company developing…

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Metagenomic Sequencing Market Set to Reach $7.1 Billion With a 17.6% CAGR by 2033

The Metagenomic Sequencing Market witnessed a significant global revenue of US$ 1.2 Billion in 2022. It is projected to experience a remarkable growth rate of 17.6% from 2023 to 2033, ultimately reaching a valuation of US$ 7.1 Billion by the conclusion of the forecast period. The Metagenomic Sequencing Market has emerged…

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Illumina disinvests in cancer test maker Grail after antitrust battles- Republic World

Illumina to divest cancer test maker Grail after antitrust battles | Image:PTI   The gene sequencing business Illumina announced on Sunday that it will sell its stake in Grail, a manufacturer of cancer diagnostic tests, following more than two years of legal battles with European and American antitrust authorities and…

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Validation of Oxford nanopore sequencing for improved New World Leishmania species identification via analysis of 70-kDA heat shock protein | Parasites & Vectors

Akhoundi M, Downing T, Votypka J, Kuhls K, Lukes J, Cannet A, et al. Leishmania infections: molecular targets and diagnosis. Mol Aspects Med. 2017;57:1–29. Article  PubMed  Google Scholar  Akhoundi M, Kuhls K, Cannet A, Votypka J, Marty P, Delaunay P, et al. A historical overview of the classification, evolution, and…

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First Wave BioPharma Announces Entry into Term Sheet for

Phase 3-ready latiglutenase, a targeted oral biotherapeutic for celiac disease, will expand First Wave BioPharma’s late-stage gastrointestinal (GI) disease clinical pipeline A concurrent institutional investment and a strategic U.S. license agreement with a global pharmaceutical company is anticipated to be completed post-closing BOCA RATON, Fla., Dec. 18, 2023 (GLOBE NEWSWIRE)…

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Illumina will divest Grail after losing battle with FTC. How did the San Diego biotech’s $7B deal unravel?

San Diego biotech giant Illumina said Sunday that it is divesting Grail, the early cancer-detection company it acquired for roughly $7 billion, after its legal battle with U.S. antitrust regulators failed. The deal has weighed on Illumina for several years by plunging it into legal challenges with U.S. and European…

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UniProtKB/SwissProt variant VAR_013096

UniProtKB/SwissProt variant VAR_013096 Glycogen phosphorylase, liver form Gene: PYGL Feedback? Literature citations No reference for the current variant in UniProtKB/Swiss-Prot. Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as…

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UPDATE 1-Illumina to divest cancer test maker Grail

(Adds details from Illumina’s statement in paragraph 2, background in paragraph 3-7) Dec 17 (Reuters) – Illumina said on Sunday that it would divest cancer diagnostic test maker Grail after the companies battled both U.S. and European antitrust enforcers for more than two years and faced fierce opposition from activist…

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Study To Measure Cell-Free DNA Capture Potential Of BioCaptis Device

BIOCAPTIVA Ltd. has begun an ex-vivo study to determine whether its BioCaptis device can isolate pleural fluid cell-free DNA (cfDNA) from exudative pleural fluid samples in sufficient quantities to improve pleural disease diagnosis. The study will involve a collaboration between BioCaptiva, University of the Highlands and Islands (UHI), and NHS Highland….

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qPCR Reagents Market is Anticipated to reach above USD 2.12 billion by 2030, grow at +8 % CAGR from 2023 to 2030

qPCR Reagents Market qPCR Reagents Market is expected to grow at 8 % CAGR from 2023 to 2030. It is expected to reach above USD 2.12 billion by 2030 from USD 1.23 billion in 2023. qPCR reagents are essential components used in the qPCR or RT-PCR process, allowing researchers to…

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Dawn of a Health Revolution: The Coming Breakthroughs Poised to Transform Medicine | by Dr Axel Coach | Dec, 2023

[High-concept in Medicine] The Latest Research in Medicine Photo by National Cancer Institute on Unsplash The future is rushing toward us with dizzying speed, bearing dazzling innovations that promise to reshape the landscape of medicine. Genetic diseases erased with the flick of a molecular scalpel; custom-grown organs fresh off the…

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Molecular Weight Marker Market is Projected to grow at +12.1% CAGR from 2023 To 2030 by Exactitude Consultancy

Molecular Weight Marker Marke The molecular weight marker market is expected to grow at 12.1% CAGR from 2023 To 2030. It is expected to reach above USD 938.76 million by 2030. Molecular weight markers are reference standards used in gel electrophoresis and other molecular biology techniques to estimate the size…

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US court strikes down FTC order against Illumina’s purchase of Grail – Business

Business Business US court strikes down FTC order against Illumina’s purchase of Grail Close US court strikes down FTC order against Illumina’s purchase of Grail Follow on Published On: Sat, 16 Dec 2023 …

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Nucleic Acid Isolation Kit Market Analysis Competitive Landscape, Growth Factors, Revenue |Thermo Fisher Scientific, Roche, Qiagen, Corning, Precision System Science

[New York, December 2023] A comprehensive market analysis report on the Nucleic Acid Isolation Kit Market has been unveiled by Stats N Data, offering valuable insights and intelligence for both industry veterans and newcomers. This in-depth report not only provides revenue forecasts for the Nucleic Acid Isolation Kit market and…

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Timeline: What will health care look like 20 years in the future?

Next-generation diagnostic platforms COVID-19 was a wakeup call, exposing the limitations of many current diagnostic platforms. Innovations in diagnostic testing, driven by the need to respond to COVID-19, could help provide essential tools in the fight against other diseases. Diagnostic tools are critical to improving global health. Lessons learned…

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UPDATE 2-US court strikes down FTC order against Illumina’s purchase of Grail

(Adds details from ruling and comment from Illumina in paragraphs 2-8) By Diane Bartz and Mike Scarcella Dec 15 (Reuters) – A U.S. appeals court on Friday struck down a Federal Trade Commission order against Illumina’s purchase of cancer diagnostic test maker Grail , a former subsidiary, saying the agency…

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Lipid Nanoparticles (LNPs) CDMO Market Latest Trends and Future Opportunities Analysis to 2031

“Global Lipid Nanoparticles (LNPs) CDMO Market Focus on Nucleic Acids LNPs Segmented By Product (mRNA , Plasmid DNA (pDNA), siRNA, saRNA, microRNA, and Others), Scale Of Operation (Preclinical, Clinical , and Commercial), End-Users (Pharmaceutical Companies, Academic Research Institute, and Diagnostic Laboratories)- Trends, Industry Competition Analysis, Revenue and Forecast To 2030.”…

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Gadolinium Oxide Nanoparticles reinforce immune response

Boyi Yu,1– 4 Xuanyi Lu,5 Xianglong Feng,1– 4 Ting Zhao,1– 4 Jiaxin Li,1– 4 Yudie Lu,5 Fei Ye,1– 4 Xiongxiong Liu,1– 4 Xiaogang Zheng,1– 4 Zheyu Shen,5 Xiaodong Jin,1– 4 Weiqiang Chen,1– 4 Qiang Li1– 4 1Biomedical Center, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, People’s Republic of…

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Precision Medicine: A New Era in Cancer Therapy

Precision medicine can offer improved clinical outcomes by assessing the unique characteristics of tumors, such as their likelihood of developing resistance to chemotherapy. Stay up to date on the latest science with Brush Up Summaries.  Precision Medicine in Cancer Precision medicine for cancer treatment involves tailoring treatments to an individual…

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Special Issue : Extracellular Vesicles and ncRNA

Dear Colleagues, Over the past two decades, the biological science arena has witnessed the emergence and rapid advancement of two distinct research domains: noncoding RNA (ncRNA) and extracellular vesicles. Presently, the significance of ncRNA in the biology of virtually all living organisms is beyond dispute, and our comprehension of its…

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Streamlining point-of-care assays | Nature Biomedical Engineering

When designing diagnostic assays intended for point-of-care use, more attention should be given to simplicity of operation. When it comes to assays for the detection of disease biomarkers, analytical performance typically makes the headline. An assay that misses a substantial percentage of samples positive for the biomarker or that singles…

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NGS Sample Preparation Market Surges with a Remarkable 13.7% CAGR, Setting Sights on US$ 5442.1 Million by 2032-FMI Projection

PRESS RELEASE Published December 15, 2023 NGS Sample Preparation Market The value of the global NGS sample preparation market growth is projected to rise at a compound annual growth rate (CAGR) of 13.7% from 2022 to 2032, from US$ 1321.8 million in 2022 to US$ 5441.1 million in 2032. The…

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An FGFR2 mutation as the potential cause of a new phenotype including early-onset osteoporosis and bone fractures: a case report | BMC Medical Genomics

Anamnesis vitae A 13 year old male born was as result of the VII pregnancy, from unrelated parents. Other pregnancies resulted in: I-II silent miscarriage in the second trimester; III – female, born in 2003 (III-3 Fig. 1) that has the following phenotypic features: genu valgum, hip dysplasia, combined thoracolumbar scoliosis,…

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ggplot2 – Should I update my ggplot code in R version 4.3.1?

I made code for a boxplot in R version 3.6.1: ggplot(Data_Addi, aes(x=as.factor(Sex), y=DEFS_SF, fill=as.factor(Diagnosis_Addison_Recoded))) + geom_boxplot(outlier.shape=NA, color=”black”) + geom_jitter(position=position_jitterdodge(),show.legend = FALSE) + theme_bw(base_size = 25) + scale_x_discrete(name=””, breaks=c(“1”, “2”),labels=c(“Females”, “Males”)) + scale_fill_manual(name=”Diagnostic Group”, breaks=c(“1”, “2”), labels=c(“Addison”,”Control”), values=c(“white”, “grey”)) + labs(title=”Executive function total”, x=”Sex”, y=”BDEFS-SF Total Score”) This gave the following…

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Genetic basis of osteogenesis imperfecta from a single tertiary centre in South Africa

We used ES, gene panel testing, and a single variant test to achieve a diagnostic yield of 100% for patients with OI in this study. The patient demographic is representative of the Western Cape Province, with Tygerberg Hospital being the largest tertiary referral centre in the province. Since it is…

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Germany Shifts from Next Generation Sequencing Panels to Whole Genome Sequencing Coverage

Pilot Program for the Integration of Genomic Medicine into German Healthcare Today in Germany, patients are reimbursed for the cost of NGS analysis which uses gene panels to identify diseases. Starting on the first of January, whole genome sequencing (WGS) will be reimbursed for patients at selected reference center hospitals…

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Nanoprobe with a barcode | EurekAlert!

Protein-splitting enzymes play an important role in many physiological processes. Such proteases are generally present in an inactive state, only becoming activated under certain conditions. Some are linked to diseases like infections or cancer, making it important to have methods that can selectively detect active proteases. In the journal Angewandte…

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[llvm-bugs] [Bug 75428] clang crash when build IPEX code.

Issue 75428 Summary clang crash when build IPEX code. Labels clang Assignees Reporter xuhancn The error msg: “`cmd Stack dump: 0. Program arguments: /usr/bin/clang++ -DAT_PARALLEL_OPENMP=1 -DUSE_C10D_GLOO -DUSE_DISTRIBUTED -DUSE_RPC -DUSE_TENSORPIPE -Dintel_ext_pt_cpu_EXPORTS -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/csrc/include -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/csrc/cpu -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/csrc/cpu/aten -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/csrc/cpu/utils -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/csrc/cpu/jit -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/csrc/jit -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/csrc/utils -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/third_party/ideep/mkl-dnn/include -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/csrc/cpu/tpp -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/third_party/libxsmm/include -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/build/Release/csrc/cpu/csrc/cpu/cpu_third_party/ideep/mkl-dnn/include -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/third_party/ideep/include -I/home/xu/anaconda3/envs/ipex_cpu/include/python3.12 -I/home/xu/anaconda3/envs/ipex_cpu/include -I/home/xu/anaconda3/envs/ipex_cpu/lib/python3.12/site-packages/torch/include/torch/csrc/api/include -I/home/xu/conda_spaces/ipex_cpu/frameworks.ai.pytorch.ipex-cpu/third_party/ideep/mkl-dnn/src/../include -isystem /home/xu/anaconda3/envs/ipex_cpu/lib/python3.12/site-packages/torch/include -fPIC…

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Global DNA/RNA Extraction Industry aims for a consistent 7.4% CAGR during the period spanning 2023 to 2033 as per FMI’s analysis

PRESS RELEASE Published December 14, 2023 The global DNA/RNA extraction industry is on a trajectory of substantial growth, with estimations revealing promising projections. Future Market Insights’ latest report indicates that in 2022, the market boasted a value of US$ 1.3 billion, which surged to US$ 1.40 billion in 2023. Anticipated…

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Seven precision medicine companies worth keeping an eye on

Precision medicine is an approach to tailoring treatments based on people’s genetic makeup, lifestyles and environment. These targeted interventions can tackle diseases like cancer, neurological as well as metabolic diseases. The global market value of the precision medicine industry, encompassing many companies, crossed 70 billion last year, and is expected…

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Importance of a detailed anomaly scan after a cfDNA test indicating fetal trisomy 21, 18 or 13

Kagan KO, Sonek J, Kozlowski P (2022) Antenatal screening for chromosomal abnormalities. Arch Gynecol Obstet 305(4):825–835 Article  CAS  PubMed  PubMed Central  Google Scholar  Rose NC, Barrie ES, Malinowski J, Jenkins GP, McClain MR, LaGrave D et al (2022) Systematic evidence-based review: the application of noninvasive prenatal screening using cell-free DNA…

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Global Enzymatic DNA Synthesis Market Report 2023-2028, Featuring Profiles of Telesis Bio, Twist Bioscience ,GenScript Biotech, Evonetix, Camena Bio, Molecular Assemblies, Touchlight and Kern Systems

DUBLIN, Dec. 13, 2023 /PRNewswire/ — The “Global Enzymatic DNA Synthesis Market: Analysis By Product Type (DNA Library Synthesis and Custom DNA Synthesis), By Technology (PCR, CRISPR, SOLA and Others), By Application, By End User, By Region, Size, Trends and Forecast to 2028” report has been added to  ResearchAndMarkets.com’s offering….

Continue Reading Global Enzymatic DNA Synthesis Market Report 2023-2028, Featuring Profiles of Telesis Bio, Twist Bioscience ,GenScript Biotech, Evonetix, Camena Bio, Molecular Assemblies, Touchlight and Kern Systems

Metagenomics Sequencing Market Sets New Record, Projected at USD 3.64 billion by 2028

Metagenomics Sequencing Market 2032 The increase in the number of patients suffering from chronic diseases further fuels the growth of the global metagenomics sequencing market PORTLAND, OREGON, UNITED STATES, December 13, 2023 /EINPresswire.com/ — Allied Market Research has published a study report with the title Metagenomics Sequencing Market Size…

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Harnessing Nanomedicine to Combat Hepatic Fibrosis

Understanding nanomedicinesNanomedicine in hepatic fibrosis diagnosisNanomedicine in hepatic fibrosis treatmentNanomedicine in drug delivery  Nanomedicine in targeted drug delivery  Future perspectivesReferencesFurther reading Hepatic fibrosis is an abnormal wound-healing response triggered by chronic liver diseases, including non-alcoholic fatty liver disease, viral or alcoholic hepatitis, and Wilson’s disease. The response is characterized by…

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HealthTech Arva Health launches at-home fertility test for women with PCOS, thyroid issues – Diagnostic News

Arva Health, a startup focusing on women’s healthcare through data-driven insights, has introduced home fertility tests for women. According to a press statement, the test will help women monitor and track their hormones, thus empowering them to make informed choices about their reproductive health. The test measures up to 12…

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Regression Notes.docx – advert summary .SD .SDcols=c ‘google adwords’ ‘facebook’ ‘twitter’ gives stats for 3 metrics. It is in order – Min 1st Qu.

advert[,summary(.SD),.SDcols=c(‘google_adwords’,’facebook’,’twitter’)]gives stats for 3 metrics. It is in order – Min 1stQu. Median Mean 3rdQu Max. You can check these individually using these codes: summary(advert$google_adwords) If mean and median are same then data is normally distributed View The Numeric Distributions: Creating 3 box plots side by side, we need a…

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Writing R Scripts In RStudio: A Step-By-Step Approach

Article Summary Box Mastering the RStudio interface goes beyond basic navigation, involving strategic use of panes and shortcuts to streamline the coding process. Effective script organization significantly impacts readability and maintenance, emphasizing the role of modular structuring and clear documentation. In debugging and error handling, advanced techniques like conditional breakpoints…

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Merck and Moderna Initiate INTerpath-002, a Phase 3 Study Evaluating V940 in Combination with KEYTRUDA for Adjuvant Treatment of Patients with Certain Types of Resected Non-Small Cell Lung Cancer -December 12, 2023 at 06:22 am EST

RAHWAY – Merck (NYSE: MRK), known as MSD outside of the United States and Canada, and Moderna, Inc. (Nasdaq: MRNA), today announced the initiation of INTerpath-002, a pivotal Phase 3 randomized clinical trial evaluating V940 (mRNA-4157), an investigational individualized neoantigen therapy (INT), in combination with KEYTRUDA, Merck s anti-PD-1 therapy,…

Continue Reading Merck and Moderna Initiate INTerpath-002, a Phase 3 Study Evaluating V940 in Combination with KEYTRUDA for Adjuvant Treatment of Patients with Certain Types of Resected Non-Small Cell Lung Cancer -December 12, 2023 at 06:22 am EST

What are the limitations of using 16S sequencing for taxonomic identification?

What are the challenges and opportunities in using phylogenomics to study spiders?5 answersPhylogenomics has provided valuable insights into the study of spiders, but it also presents challenges and opportunities. One challenge is the low capture efficiency of available UCE probe sets for spider phylogenomics, which are not optimized for certain…

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Diagnostic efficacy of mNGS in spinal infection patients

Introduction Spinal infection, an uncommon condition, was first recorded in 1779.1 When the intervertebral disk is infected, it is commonly referred to as spondylodiscitis,2 whereas infection of the vertebral body or endplates is more precisely termed vertebral osteomyelitis or spondylitis.3 The definitive diagnosis of spinal infection is often delayed by…

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Light-Triggered Signal Enhancement Strategy Integrated with a CRISPR/Cas13a-Based Assay for Ultrasensitive and Specific miRNA Detection

The development of facile, accurate, and affordable assays for microRNAs (miRNAs) in early cancer is greatly desirable but encounters an obstacle due to low cellular abundance in biofuids. In this study, we present a novel approach called a light-triggered exponential amplification strategy coupled with a CRISPR/Cas13a-based diagnostic system (LEXPA-CRISPR), which…

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Global Enzymatic DNA Synthesis Market Analysis, Trends and

Dublin, Dec. 12, 2023 (GLOBE NEWSWIRE) — The “Global Enzymatic DNA Synthesis Market: Analysis By Product Type (DNA Library Synthesis and Custom DNA Synthesis), By Technology (PCR, CRISPR, SOLA and Others), By Application, By End User, By Region, Size, Trends and Forecast to 2028” report has been added to ResearchAndMarkets.com‘s…

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Regulation of the ER-Resident Mannosidase EDEM2 in HEK293 Cells

Abstract EDEM2 plays an important role as the first enzyme that acts during mannose trimming of N-glycosylated proteins in the ERAD machinery. Although EDEM2 expression has been reported to be transcriptionally regulated by the IRE1-sXBP1 pathway, very little is known about how endogenous EDEM2 protein expression is regulated. In this…

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Analysis of geometric morphometrics and molecular phylogeny for Anopheles species in the Republic of Korea

World Health Organization (WHO). WHO malaria report. 2022 www.who.int/publications/i/item/9789240064898 (2022). Savi, M. K. An overview of malaria transmission mechanisms, control, and modeling. Med. Sci. 11, 3 (2023). Google Scholar  Bahk, Y. Y. et al. Epidemiological characteristics of re-emerging vivax malaria in the Republic of Korea (1993–2017). Korean J. Parasitol. 56,…

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Second “Code of Life” Cracked by AI

Understanding how genes are regulated Our DNA code provides the “blueprint” for life, enabling our cellular machinery to produce proteins that carry out essential molecular functions. While each cell possesses the same DNA code, the regulation of specific genes within that cell contribute to its unique function. Genes need to…

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$7.55 million in funding to take LHSC-developed technology global

December 12, 2023 On average it takes five to seven years to diagnose a rare disease. But, for growing numbers of rare diseases, that is all about to change with new artificial intelligence-led technology developed by researchers at London Health Sciences Centre (LHSC) and Lawson Health Research Institute that will…

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CRISPR Technology Market Size Worth USD 11.64 Billion in

Vancouver, Dec. 12, 2023 (GLOBE NEWSWIRE) — The global CRISPR Technology Market is projected to reach USD 11.64 billion by 2032, according to a recent report by Emergen Research. Certain factors that are driving the market growth include increasing government and personal funding, rising demand and adoption of CRISPR, and…

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Methylation Analysis Tutorial in R_part1

The code and approaches that I share here are those I am using to analyze TCGA methylation data. At the bottom of the page, you can find references used to make this tutorial. If you are coming from a computer background, please bear with a geneticist who tried to code…

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Panel-based RNA fusion sequencing improves diagnostics of pediatric acute myeloid leukemia

Rasche M, Zimmermann M, Borschel L, Bourquin J, Dworzak M, Klingebiel T, et al. Successes and challenges in the treatment of pediatric acute myeloid leukemia: a retrospective analysis of the AML-BFM trials from 1987 to 2012. Leukemia. 2018;32:2167–77. Article  PubMed  PubMed Central  Google Scholar  Manola KN. Cytogenetics of pediatric acute…

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Child PGI: Child PGI to get 33 docs by month end | Noida News

Noida: Child PGI will hire 33 specialists for its ophthalmology, transfusion medicine, orthopaedic, genetic disease, neurology, nephrology and cardiology departments by the end of the month. The move is set to benefit more than 3,000 children who are under treatment or consultation at the hospital.According to the hospital administration, the…

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New tool to analyze blood platelets holds maj

A novel technique to test platelet function within a person’s blood sample is faster, easier and more precise than methods currently in use, an experimental study shows. Nature Biomedical Engineering published the research, led by scientists at Emory University. The researchers demonstrated the proof-of-concept for the technique, which provides the…

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NGS Sample Preparation Market Size is Worth USD 10,342.23 Million by 2032

Emergen Research The increased advancements in NGS platforms, a decrease in the price of sequencing, and improving the NGS-based diagnostic test reimbursement scenario are driving the demand for the Next Generation Sequencing (NGS) Sample Preparation market Vancouver, Dec. 11, 2023 (GLOBE NEWSWIRE) — The global next generation sequencing (NGS) sample…

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How does sequencing depth affect the identification of bacteria, fungi and viruses?

What are some latest advances in clinical metagenomic diagnostics for pathogen detection using shirt and long read sequencing?5 answersClinical metagenomic diagnostics for pathogen detection using short and long read sequencing have seen several recent advances. Traditional pathogenic diagnosis methods have limitations such as low positivity rates and inability to identify…

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PacBio Announces the Retirement of David Botstein, Ph.D., from its Board of Directors

MENLO PARK, Calif., Dec. 11, 2023 /PRNewswire/ — PacBio (NASDAQ: PACB), a leading developer of high-quality, highly accurate sequencing solutions, announced today that David Botstein, Ph.D., a member of PacBio’s Board of Directors, has retired from his position effective December 7, 2023.   “I would like to thank David for…

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Metagenomics Market Surges as Genomic Insights Pave the Way for Breakthroughs in Microbial Exploration

PRESS RELEASE Published December 11, 2023 Market Overview Metagenomics involves the study of genetic material recovered directly from environmental samples, providing insights into the structure and function of microbial communities. The application of metagenomics spans diverse fields, including environmental microbiology, agriculture, biotechnology, and human health. Market Size and Growth Trends:…

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Liquid Biopsy Uses ctDNA to Predict Recurrence of Hodgkin Lymphoma

A Stanford Medicine-led, international study of hundreds of samples from patients with classic Hodgkin lymphoma (cHL) has shown that levels of tumor DNA circulating in the blood can identify those individuals who are responding well to treatment and those who are likely to experience a disease recurrence. The study results suggest…

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Electroporation Instruments and Consumables Market 2023-2030

The Global Electroporation Instruments and Consumables Market size reached USD 233.4 million in 2022 and is projected to witness lucrative growth by reaching up to USD 392.4 million by 2030. Electroporation Instruments and Consumables Market Overview The Electroporation Instruments and Consumables market is experiencing significant growth, driven by factors such…

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Next-generation sequencing emerges as innovative tool to detect orthopedic infections

December 11, 2023 6 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…

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What is B-Cell Receptor Repertoire Sequencing?

What is BCR-seq? B cell receptor sequencing (BCR-seq) represents an advanced and rapid method for the exhaustive detection of target-amplified B-cell receptors (BCRs) through the integration of high-throughput sequencing technology and bioinformatics. By scrutinizing the abundance of each sequence, BCR-seq unveils the intricacies of B-cell-mediated humoral immune responses and the…

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