Tag: diagnostic

Timing of DLBCL Relapse Linked With Evolutionary Patterns

Patients with diffuse large B-cell lymphoma (DLBCL) categorized as having late relapses, defined as those who relapse more than 2 years after their initial diagnosis, often have genetically distinct and chemotherapy-naive disease compared with patients with early relapses, according to findings published in the Journal of Clinical Oncology.1 Investigators noted…

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Resolving Slurm cgroups Plugin Errors on Ubuntu 22.04 Nodes

I’m working with Slurm and facing issues specifically with the cgroups plugin on Ubuntu 22.04 nodes. Our team is relatively new to Slurm, and we’ve been trying to optimize our resource management for complex computing tasks. However, we’ve encountered a series of errors that are proving difficult to resolve. Here’s…

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Short-read whole genome sequencing identifies causative variants in most individuals with previously unexplained aniridia

Classical aniridia is an eye malformation caused by the loss of one working copy of the PAX6 gene, but a minority of cases remain genetically unsolved. We sequenced the whole genomes of 37 affected families (51 individuals) where PAX6 had previously been sequenced but no causative mutation was found. We…

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Troubleshooting Slurm cgroups Plugin on Ubuntu 22.04

I’m facing a challenging issue with the Slurm cgroups plugin on a system running Ubuntu 22.04. We’re relatively new to Slurm and started using it for better resource management in complex computing tasks. However, we’ve hit a snag with the cgroups plugin, particularly on our Ubuntu 22.04 nodes. Here’s what…

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Comprehensive analysis of necroptotic patterns and associated immune landscapes in individualized treatment of skin cutaneous melanoma

Identification of the SKCM necroptosis cluster The comprehensive analysis encompassed a total of 803 patients drawn from five distinct melanoma cohorts, namely, TCGA-SKCM, GSE65094, GSE53118, GSE54467, and GSE19234. Employing an unsupervised clustering algorithm, we stratified melanoma patients based on their NRG expression profiles. This facilitated a deeper exploration of the…

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Extraction-free LAMP assays for generic detection of Old World Orthopoxviruses and specific detection of Mpox virus

Phylogenomic analysis of Orthopoxvirus genomes A phylogenomic analysis of 200 Orthopoxvirus genomes, identified 10 distinct clades within this genus, which are here named as phylogroups 1 to 10 and are denoted as OPV-PG-01 to OPV-PG-10 (Fig. 1) based on their nesting patterns (Supplementary Fig. S1), where the 100 MPV isolates included…

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A Reliable Method for Quantifying Plasma Cell-Free DNA Using an Internal Standard Strategy: Evaluation in a Cohort of Non-Pregnant and Pregnant Women

Martignano F. Cell-free DNA: an overview of sample types and isolation procedures. In: Casadio V, Salvi S, editors. Cell-free DNA as diagnostic markers. Methods in molecular biology, Vol. 1909. New York, NY: Humana Press; 2019. p. 13–27. doi.org/10.1007/978-1-4939-8973-7_2. Volckmar AL, Sültmann H, Riediger A, Fioretos T, Schirmacher P, Endris V,…

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Vacature Postdoc position in Bioinformatics

In this TKI-PPP funded project, our objective is to construct a comprehensive landscape of the tumor microenvironment in cervical cancer patients and investigate its potential clinical applications using cutting-edge bioinformatic and molecular profili… Cervical cancer ranks fourth leading causes of cancer death in women globally, with approximately 800-900 diagnosis annually…

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Frontiers Publishing Partnerships | Donor-Derived Cell-Free DNA: Attractive Biomarker Seeks a Context of Use

A Forum discussing: Donor-Derived Cell-Free DNA (ddcfDNA) in Kidney Transplant Recipients With Indication Biopsy—Results of a Prospective Single-Center Trial by Benning L, Morath C, Fink A, Rudek M, Speer C, Kälble F, Nusshag C, Beimler J, Schwab C, Waldherr R, Zeier M, Süsal C and Tran TH (2023). Transpl Int….

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Identification of differentially expressed circRNAs in prostate cancer of different clinical stages by RNA sequencing

CircRNAs are widely found in eukaryotes and are a class of abundantly expressed, highly tissue-specific, and stable non-coding RNAs that have an essential role in regulating gene expression12. The abnormal expression of circRNAs has been reported in esophageal squamous cell carcinoma13, breast carcinoma14, gastric cancer15, and hepatocellular carcinoma16, which are…

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Comparison of Tests for Systemic Lupus Erythematosus Diagnosis and Disease Monitoring

Systemic lupus erythematosus (SLE) is characterized by autoantibody production, with anti-dsDNA antibodies (anti-dsDNA) being a key indicator for SLE diagnosis and disease monitoring. A new study compared the results of two different tests that measure anti-dsDNA, an enzyme immunoassay (EIA, a blood or urine analysis that can help diagnose many infections…

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Are We Ready For Human Gene Editing? | by Prarthan Ghosh | Forum for Ethical Technology Advancement | Nov, 2023

Made with DALL-E 3 Picture a world where expectant parents sit down at a computer screen, and much like a character creator in a video game, design their child. They can modify physical appearance, intelligence, athleticism, and even personality. In this not-so-distant future, gene editing technology may very well transform…

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CRISPR Gene Editing: Cas9 and Beyond

Scientists use the CRISPR-Cas9 system to target a DNA sequence of interest near a protospacer-adjacent motif (PAM). The PAM initiates Cas9-DNA binding, a guide RNA (yellow) invades the double helix (blue) and hybridizes with the target DNA, and Cas9 (red) breaks the unwound double-stranded target DNA. iStock Meletios Verras Stay…

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The future of primary biliary cholangitis treatment

On the podcast this week, we are looking at recent advances in treating certain liver diseases. Jennifer Schranz is senior vice president and global head of rare diseases in the R&D division at Ipsen, and she discusses a breakthrough treatment for primary biliary cholangitis and cholestatic liver disease. What is…

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DNA methylation change in blood cells of FB and CFS patients

Introduction Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) are characterized by chronic pain, fatigue, and weakness. Patients with these symptoms also suffer from sleep abnormalities and report affected cognitive processes such as memory. The diagnosis of these two syndromes is challenging and is based on questionnaires that make the diagnosis…

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The only way is Esox

Can you tell me a bit about your background? I was born in London, UK to an Irish mother and Canadian father. School holidays were spent in each country whereby I established my passion for fish, fishing and the aquatic world. Every day would be spent by the water: watching…

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Longitudinal detection of circulating tumor DNA

Analysis of Roche KAPA Target Enrichment kit experimental data obtained on an Illumina sequencing system is most frequently performed using a variety of publicly available, open-source analysis tools. The typical variant calling analysis workflow consists of sequencing read quality assessment, read filtering, mapping against the reference genome, duplicate removal, coverage…

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Germline PTEN genotype-dependent phenotypic divergence during the early neural developmental process of forebrain organoids

American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Arlington, VA: American Psychiatric Publishing; 2013. Lewis MH, Bodfish JW. Repetitive behavior disorders in autism. Ment Retard Dev D R. 1998;4:80–9. Article  Google Scholar  Bodfish JW, Symons FJ, Parker DE, Lewis MH. Varieties of repetitive behavior in…

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Bionano Announces Publication Demonstrating Utility of OGM

SAN DIEGO, Nov. 29, 2023 (GLOBE NEWSWIRE) — Bionano Genomics, Inc. (Nasdaq: BNGO) today announced a publication demonstrating the use of optical genome mapping (OGM) to identify structural variations (SVs) introduced by CRISPR-Cas9 gene editing of CD4+ T-cells that could potentially limit the therapeutic use of such edited cells. The research…

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Oxford Nanopore and WeNou Announce a Partnership to Develop and Commercialise the First Rapid and Portable Food Authenticity Sequencing Test to Detect Food Fraud

Oxford Nanopore’s sequencing devices and kits with WeNou’s expertise will be used to develop a validated food authenticity workflow to meet industry standards OXFORD, England, November 29, 2023–(BUSINESS WIRE)–Oxford Nanopore Technologies (Oxford Nanopore) and WeNou, a company providing innovative services based on DNA analysis for the food and feed sectors,…

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Bioinformatics Market to Surpass $83.9 Billion by 2030: Coherent Market Insights

CMI Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data, in particular when annotating genomes and interpreting biological meaning. It is used for biological experiments and computations to determine relationships among biological systems. Burlingame, Nov. 28, 2023 (GLOBE NEWSWIRE) — According to Coherent Market Insights,…

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Greenphire, Florence Healthcare Team Up; Illumina Partnerships; Oxford Nanopore Develops New Data Technology

November 29, 2023 | Greenphire and Florence Healthcare announce a technology partnership; Illumina and Veracyte join together in a multi-year agreement; Oxford Nanopore Technologies collaborates with Fabric Genomics and Saphetor to develop data technology for research; more.  Greenphire and Florence Healthcare announced a technology partnership that integrates two of the…

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Bioinformatics – Intern at Exact Sciences

Position Overview/Summary Exact Sciences is seeking a Bioinformatics intern to help optimize and improve the algorithms in the MRD program. Essential Duties Include, but are not limited to, the following: Assist with routine operation of our sequencing bioinformatic analysis pipeline. Create and optimize new and existing bioinformatics pipelines. Perform analysis…

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Identification and characterization of ARID1A-interacting proteins in renal tubular cells and their molecular regulation of angiogenesis | Journal of Translational Medicine

Centore RC, Sandoval GJ, Soares LMM, Kadoch C, Chan HM. Mammalian SWI/SNF chromatin remodeling complexes: emerging mechanisms and therapeutic strategies. Trends Genet. 2020;36:936–50. Article  CAS  PubMed  Google Scholar  Pagliaroli L, Trizzino M. The Evolutionary conserved SWI/SNF subunits ARID1A and ARID1B Are Key modulators of pluripotency and cell-fate determination. Front Cell…

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Portable DNA Sequencers Rapidly Detect Malaria Drug Resistance

Edem Adika loading a flow cell in Accra. Credit: William Hamilton Key points: Scientists working in Ghana developed an on-site technique to rapidly and reliably detect genetic changes in malaria parasites. The team’s genetic surveillance technique is an accessible, low cost, near real-time approach that only requires a gaming laptop…

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Proteomics and metabolomics analyses of Streptococcus agalactiae isolates from human and animal sources

Shen, C.-H. Molecular diagnosis of infectious diseases in Diagnostic Molecular Biology Ch. 15, 387–411 (Academic Press, C 2019). Katholm, J., Bennedsgaard, T. W., Koskinen, M. T. & Rattenborg, E. Quality of bulk tank milk samples from Danish dairy herds based on real-time polymerase chain reaction identification of mastitis pathogens. J….

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Improved CRISPR Diagnostic Technology Enhances Efficacy and Efficiency for Nucleic Acid Detection

– Advertisement – Efficacy and Efficiency of CRISPR Diagnostic Technology Improved Researchers have developed a new method that improves existing diagnostic technology for a more rapid, sensitive, and deployable approach to molecular diagnostics. The research, published in Nature Communications, unravels new potential for simple and sensitive nucleic acid detection in…

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Single Nucleotide Polymorphism (SNP) Genotyping Market 2023,

Single Nucleotide Polymorphism (SNP) Genotyping Global Market The Business Research Company’s global market reports are now updated with the latest market sizing information for the year 2023 and forecasted to 2032 The Business Research Company’s Single Nucleotide Polymorphism (SNP) Genotyping Global Market Report 2023 identifies The increasing burden of chronic…

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Shooting for the stars: The healthtech using cosmology and AI to try to cure cancer

Dubbed the “emperor of all maladies” by physician and Pulitzer Prize winner Siddhartha Mukherjee, cancer is the cause of one in six deaths worldwide. The disease blights the lives of millions because of its complexity and shape-shifting ability to elude the human immune system and adapt to treatments.  But there…

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Comprehensive Molecular Tumor Analysis (CMTA) integrating RNAseq and tumor immune microenvironment (TME) for targeted therapy (India)

Precision oncology approaches have made great strides harnessing individual tumor mutation profiles to guide targeted therapy choices. However, deeper molecular insights are needed to improve personalized treatment decisions that are tailored to specific molecular characteristics of a tumor. Integrating gene expression analysis in personalized oncology provides an additional level of…

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Exploring the promising potential of induced pluripotent stem cells in cancer research and therapy | Molecular Cancer

Rowe RG, Daley GQ. Induced pluripotent stem cells in disease modelling and drug discovery. Nat Rev Genet. 2019;20:377–88. Article  CAS  PubMed  PubMed Central  Google Scholar  Li L, Papadopoulos V. Advances in stem cell research for the treatment of primary hypogonadism. Nat Rev Urol. 2021;18:487–507. Article  CAS  PubMed  Google Scholar  Lawrence…

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Five biotech companies in Texas shaping the state’s hubs

Thanks to the U.S. government’s ambitious plans to advance American biotech and biomanufacturing, Texas’ life sciences hubs, particularly in Dallas and Houston, are now one of many in the country that are currently thriving. In this article, we take a closer look at several biotech companies in Texas taking advantage…

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Compact DNA Sequencers Monitor Malaria Drug Resistance in Near Real-Time

Register for free to listen to this article Thank you. Listen to this article using the player above. ✖ Want to listen to this article for FREE? Complete the form below to unlock access to ALL audio articles. Scientists have developed a technique to rapidly and reliably…

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IDTechEx Explores Hyper Personalized Approaches to Healthcare

BOSTON, Nov. 28, 2023 /PRNewswire/ — The future of healthcare is increasingly personalized, with smartwatches that can monitor key vital signs from the comfort of the living room to genetic testing that can tell people vital information about their health. Tracking information within the body and having doctors able to…

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The crucial role of tissue quality in precision oncology

In precision oncology, tissue quality plays a pivotal role in maintaining data integrity. We explore the impact of standardizing tissue collection and processing on data quality, and how this helps enhance patient outcomes as well as our understanding of cancer. Insights from tissue samples play an important role across the…

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188 New Systems Unveiled by Smart Algorithm

Researchers at MIT, the Broad Institute, and the National Institutes of Health have developed a new search algorithm that has identified 188 kinds of new rare CRISPR systems in bacterial genomes. Credit: Broad Institute By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a…

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What Is DNA Methylation? Definition & Overview

DNA methylation is a fundamental epigenetic modification mechanism that is crucial in regulating gene activity. It involves adding a methyl group to the DNA molecule, specifically to the cytosine base. This process is vital for various cellular functions, including regulating gene expression, where specific genes are activated or silenced based…

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Genomics Market size is set to grow by USD 18.24 billion from 2022-2027 | Reduction in the cost of genetic sequencing to boost the market growth

NEW YORK, Nov. 27, 2023 /PRNewswire/ — The significant driver in the genomics market is the decreased cost of genetic sequencing, driven by the completion of the Human Genome Project (HGP) and advancements in genomics. Innovations in technologies such as NGS, DNA microarray, and CRISPR have revolutionized sequencing methods, allowing for targeted…

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Genomics Market size is set to grow by USD 18.24 billion from 2022-2027 | Reduction in the cost of genetic sequencing to boost the market growth- Technavio

NEW YORK, Nov. 27, 2023 /PRNewswire/ — The significant driver in the genomics market is the decreased cost of genetic sequencing, driven by the completion of the Human Genome Project (HGP) and advancements in genomics. Innovations in technologies such as NGS, DNA microarray, and CRISPR have revolutionized sequencing methods, allowing for targeted…

Continue Reading Genomics Market size is set to grow by USD 18.24 billion from 2022-2027 | Reduction in the cost of genetic sequencing to boost the market growth- Technavio

A key player in gene expression variation and disease manifestation

Professor Asaf Hellman and his research team at the Hebrew University-Hadassah Medical School have unveiled new findings in the realm of methylation-directed regulatory networks. Their study sheds light on the mechanisms governing the activation and suppression of mutation-driven disease genes, particularly in cases like glioblastoma, offering insights into variations in…

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An AI Tool Just Revealed Almost 200 New Systems for CRISPR Gene Editing

CRISPR has a problem: an embarrassment of riches. Ever since the gene editing system rocketed to fame, scientists have been looking for variants with better precision and accuracy. One search method screens for genes related to CRISPR-Cas9 in the DNA of bacteria and other creatures. Another artificially evolves CRISPR components…

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Biopharmaceuticals Market Size to Surpass USD 799.76 Billion by 2030, at a CAGR of 7.9%

As per the report by Fortune Business Insights, The Biopharmaceuticals Market size is projected to reach USD 799.76 Billion by 2030, at a CAGR of 7.9% during the forecast period. Biopharmaceuticals Market Biopharmaceuticals Market (2023-2030) Pune, India, Nov. 27, 2023 (GLOBE NEWSWIRE) — The global biopharmaceuticals market size was USD…

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Evolution Midterm 1 Cheat Sheet – DNA Markers: nuclear DNA SNPs, mtDNA, SNPs, DNA sequences,

DNA Markers: nuclear DNA SNPs, mtDNA, SNPs, DNA sequences, microsatellites Popular neutral markers: Mitochondrial gene sequences (COI: animal), SNPs (single nucleotide polymorphisms), nuclear sequence (RUBISCO, rDNA: plants) (show SNP heteros have 2 lower peaks), genome resequencing, microsatellites (STR) Microsatellites: tandem repeats of 10-30 copies of 2-4 base pairs (diff in…

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Personalized Psychiatry Market Size is expected to reach US$ 7.16 billion at a CAGR of 10.6% by 2030

The Personalized Psychiatry market is estimated to be valued at US$ 3.54 billion in 2023 and is expected to exhibit a CAGR of 10.6% over the forecast period 2023-2030, as highlighted in a new report published by Coherent Market Insights. Market Overview: Personalized psychiatry is a branch of psychiatry that…

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POCKET-SIZED DNA SEQUENCERS TRACK MALARIA DRUG RESISTANCE IN GHANA IN NEAR REAL-TIME

For immediate release: 27 November 2023 Peer-reviewed / Observational / Cells POCKET-SIZED DNA SEQUENCERS TRACK MALARIA DRUG RESISTANCE IN GHANA IN NEAR REAL-TIME Scientists have developed a technique to rapidly and reliably detect genetic changes in malaria parasites in Ghana, using just a gaming laptop and portable MinION sequencer from…

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boosting biotech innovation in Australia

Research and development (R&D) stands as a cornerstone for driving innovation, particularly within the biotech industry. The pivotal role of R&D extends beyond immediate commercial implications and encompasses a broader spectrum of societal and economic benefits. R&D represents significant expense, and if big companies can afford the risk, it may…

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Scientists discovered thousands of rare new CRISPR systems

Microbial biochemical systems are incredibly diverse, and computational tools to analyze sequence data are essential in identifying new and valuable components for biotechnology development. Scientists from the National Center for Biotechnology Information (NCBI) at the National Institutes of Health, the McGovern Institute for Brain Research at MIT, and the Broad…

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Thermo Fisher Scientific Jobs – Bioinformatics Internship, Machine Learning I in Santa Clara, California, United States

Job Description When you’re part of the team at Thermo Fisher Scientific, you’ll do important work. You’ll have the opportunity to grow and learn in a culture that empowers your development. We have created an inclusive, global environment that values the power of diverse talent, backgrounds, and experiences to drive…

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New Method for Prenatal Genetic Testing Developed

A team of investigators from Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), and the Broad Institute of MIT and Harvard have developed a non-invasive genetic test that can screen the blood of pregnant individuals to survey all genes for fetal DNA sequence variants. The team evaluated the test…

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Rhumbline Advisers Sells 980 Shares of Myriad Genetics, Inc. (NASDAQ:MYGN)

Rhumbline Advisers decreased its stake in Myriad Genetics, Inc. (NASDAQ:MYGN – Free Report) by 0.4% during the 2nd quarter, according to the company in its most recent Form 13F filing with the Securities and Exchange Commission. The fund owned 267,994 shares of the company’s stock after selling 980 shares during…

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KEGG DRUG: Tolbutamide

KEGG DRUG: Tolbutamide     DRUG: Tolbutamide Help Entry D00380                      Drug                                    Name Tolbutamide (JP18/USP/INN);Orinase (TN) Formula C12H18N2O3S Exact mass 270.1038 Mol weight 270.3479 Structure Mol fileKCF fileDB search Simcomp Neighbor Class Antidiabetic agent DG01508  Sulfonylurea receptor agonist  DG01734  Sulfonylurea DG02044  Hypoglycemic agent  DG01734  Sulfonylurea Remark Efficacy Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist   Disease Non-insulin-dependent diabetes mellitus, type II [DS:H00409] Comment Sulfonylurea…

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Top 5 Best Nanotech Companies In India 2024

In a world where innovation continues to shape our future, nanotechnology has emerged as a transformative force. India, with its remarkable scientific prowess and technological advancements, is at the forefront of this revolution. As we step into 2024, it’s an exciting time to explore the Top 5 Best Nanotech innovations…

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Molecular complexity of diffuse large B-cell lymphoma: a molecular perspective and therapeutic implications

Agarwal P, Kabir FM, DeInnocentes P, Bird RC (2012) Tumor suppressor gene p16/INK4A/CDKN2A and its role in cell cycle exit, differentiation, and determination of cell fate. Tumor Suppressor Genes 3(10):27882 Google Scholar  Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E et al (2022) The 5th edition…

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The genomic epidemiology of shigellosis in South Africa

Institue for Health Metrics and Evaluation. Global Burden of Disease. vizhub.healthdata.org/gbd-results/ 2019. Troeger, C. E. et al. Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017. Lancet Infect. Dis. 20, 37–59 (2020)….

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Development and evaluation of specific polymerase chain reaction assays for detecting Theileria equi genotypes | Parasites & Vectors

Knowles DP, Kappmeyer LS, Stiller D, Hennager SG, Perryman LE. Antibody to a recombinant merozoite protein epitope identifies horses infected with Babesia equi. J Clin Microbiol. 1992;30:3122–6. CAS  PubMed  PubMed Central  Google Scholar  Ueti MW, Palmer GH, Kappmeyer LS, Statdfield M, Scoles GA, Knowles DP. Ability of the vector tick…

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Insightful Forecast: Global DNA Sequencing Market CAGR Anticipations of 18.02% till 2028, DelveInsight Insights | Agilent Techn, Roche, Illumina, PerkinElmer, Merck, QIAGEN, Thermo Fisher

Adenine, Guanine, Cytosine, and Thymine are the nucleotide base pairs that make up the majority of genetic information. DNA sequencing is essentially a way to determine the sequence of these base pairs. As per DelveInsight’s assessment, the DNA Sequencing Market is expected to grow at an immense pace in the…

Continue Reading Insightful Forecast: Global DNA Sequencing Market CAGR Anticipations of 18.02% till 2028, DelveInsight Insights | Agilent Techn, Roche, Illumina, PerkinElmer, Merck, QIAGEN, Thermo Fisher

DNA Methylation Market to reach USD 4,067 million by 2030 according to a new research report

DNA methylation, an epigenetic mechanism involving the addition of a methyl group to DNA, is altering the landscape of genetic research and healthcare. The market, valued at USD 1,349 million in 2021, is projected to soar to USD 4,067 million by 2030. This growth is driven by the increasing use…

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Comparative analysis of conventional ultrasound and shear wave elastography features in primary breast diffuse large B-cell lymphoma

BACKGROUND Primary breast diffuse large B-cell lymphoma (PB-DLBCL) is a rare subtype of non-Hodgkin lymphoma that accounts for < 3% of extranodal lymphomas and 1% of breast tumors. Its diagnosis and management are challenging because of its rarity, heterogeneity, and aggressive behavior. Conventional ultrasound (US) is the first-line imaging modality…

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Digital Genome Market is Estimated to Witness High Growth Owing

The Digital Genome Market is estimated for 2023 for the forecast period 2023-2030, as highlighted in a new report published by Coherent Market Insights. Market Overview: The digital genome is a digital representation of an organism’s complete set of DNA. It involves converting DNA sequences into digital data that can…

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ABL Diagnostics expands its commercial network and collaborations to offer unique Sanger & NGS based microbiology genotyping assays and software worldwide.

ABL Diagnostics spreading the DeepChek® technology (suite of Sanger & NGS assays and software systems) to laboratories performing infectious diseases genotyping. The company continues to expand its network of distribution partners in all continents to offer its expertise and innovative solutions to reference microbiology laboratories. Woippy (France) – ABL Diagnostics…

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ABL Diagnostics Grows Global Reach to Provide Unique Sanger & NGS Microbiology Genotyping Assays and Software

ABL Diagnostics, a Euronext-listed company that develops molecular biology assays and software for microbiology laboratories, has announced the expansion of its network of exclusive distributors. The distributors will offer the DeepChek® technology, a suite of Sanger & NGS assays and software systems, to laboratories performing infectious diseases genotyping. With the…

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Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study

Genetic characterization For risk stratification and identification of genetic aberrations suitable as MRD targets, diagnostic material from 133 children with primary AML was examined (see “Methods” and Supplementary Table 3). The presence of selected fusion genes and mutations was prospectively investigated using (q)RT-PCR and sequencing. A primary genetic aberration was found…

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Pan-Cancer Analysis and Validation of Opioid-Related Receptors Reveals

Introduction The potential role of opioids used in oncology patients has been controversial. Epidemiological and retrospective studies have demonstrated that lower opioid doses and regional anesthesia (epidural, intrathecal, or paravertebral) for breast,1 colon,2 or melanoma3 are linked to lower rates of cancer recurrence, while general anesthesia with high opioid doses…

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‘Treasure trove’ of new CRISPR systems holds promise for genome editing

The CRISPR–Cas9 system (pictured) is used to find and cut specific DNA sequences.Credit: Carlos Clarivan/Science Photo Library CRISPR–Cas9 is best known as a laboratory tool for editing DNA, but its natural function is as part of the immune system that helps microorganisms to fight off viruses. Now, researchers have used…

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Search algorithm reveals nearly 200 new kinds of CRISPR systems | MIT News

Microbial sequence databases contain a wealth of information about enzymes and other molecules that could be adapted for biotechnology. But these databases have grown so large in recent years that they’ve become difficult to search efficiently for enzymes of interest. Now, scientists at the McGovern Institute for Brain Research at…

Continue Reading Search algorithm reveals nearly 200 new kinds of CRISPR systems | MIT News

Functional filter for whole-genome sequencing data identifies HHT and stress-associated non-coding SMAD4 polyadenylation site variants >5 kb from coding DNA

Summary Despite whole-genome sequencing (WGS), many cases of single-gene disorders remain unsolved, impeding diagnosis and preventative care for people whose disease-causing variants escape detection. Since early WGS data analytic steps prioritize protein-coding sequences, to simultaneously prioritize variants in non-coding regions rich in transcribed and critical regulatory sequences, we developed GROFFFY,…

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Mpox (monkeypox)- Democratic Republic of the Congo

Situation at a Glance Mpox is an infectious disease caused by monkeypox virus (MPXV), which is endemic in densely forested regions of West, Central and East Africa, particularly in the northern and central regions of the Democratic Republic of the Congo. Eleven of the 26 provinces of the Democratic Republic…

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Detection of monkeypox virus using helicase dependent amplification and recombinase polymerase amplification combined with lateral flow test | Virology Journal

In recent years, MPX has evolved into a global epidemic and a “public health emergency of international concern” [14]. Early in its discovery, MPX was frequently misdiagnosed as smallpox due to the similarity of its symptoms to those of smallpox. Since smallpox has been eradicated, the routine diagnosis of MPX…

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DNA Sequencing Market Insights: Unraveling Business

DNA Sequencing Market Market Overview: DNA sequencing is the process of determining the order of nucleotides in DNA. It is used to study genomes and genetic variation as well as to diagnose diseases and guide treatment decisions. The market includes instruments, consumables, and software & services used for DNA sequencing…

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Genetic predisposition to early breast cancer

image:    Figure 2: The spectrum of pathogenic variants in the early-onset breast cancer cohort. view more  Credit: 2023 Zhunussova et al. “Our study may reveal previously uncharacterized population-specific variants that may increase the risk of BC in the Kazakh population.” BUFFALO, NY- November 22, 2023 – A new research…

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Senior Bioinformatics Support Specialist – it-jobs-switzerland.ch

This is a version of the job ad optimized for mobile devices. Show original job ad The Position ROLE SUMMARY: Creates,  reviews, and maintains training content and training documentation for job-oriented training in cooperation with regional training centers. Training are executed and supported for end customers, first-level support, regional trainers,…

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Genomic characterization of SARS-CoV-2 from Uganda using MinION nanopore sequencing

In this study, we sequenced and characterized 49 SARS-CoV-2 samples from Uganda, collected between April 2020 and July 2021, using MinION Nanopore sequencing. Overall, the ARTIC protocol used was able to generate the required libraries for successful sequencing on the long-read sequencer. MinION Oxford Nanopore technology enabled the identification of…

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What Type Of Software Application Is RStudio

Features of RStudio RStudio is a powerful integrated development environment (IDE) specifically designed for the R programming language. It offers a wide range of features that enhance the efficiency and productivity of R programmers. Let’s explore some of the key features of RStudio: Intuitive Code Editing: RStudio provides a clean…

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Non-invasive genetic test for fetal DNA sequencing developed

A team of investigators from Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), and the Broad Institute of MIT and Harvard have developed a non-invasive genetic test that can screen the blood of pregnant individuals to survey all genes for fetal DNA sequence variants. The team evaluated the test…

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Analysis of nucleoporin 107 overexpression

Introduction Lung cancer is one of the most common types of cancer worldwide and the leading cause of cancer death.1 The main category of lung cancer is non-small cell lung cancer, accounting for about 85%, and lung adenocarcinoma, as a kind of non-small cell lung cancer, is the most frequently…

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BioVie: Cautiously Optimistic Ahead Of Phase 3 Alzheimer’s Data Unblinding (NASDAQ:BIVI)

BlackJack3D Intro Neurodegenerative disease-focused BioVie (NASDAQ:BIVI) recently presented a set of blinded data which, if taken at face value, suggest that its lead asset NE3107 may have robust (and potentially unprecedented) cognitive and biomarker efficacy in Alzheimer’s disease. On October 25th, the company presented blinded data from its Phase 3…

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Researchers develop new method for prenatal genetic testing

Credit: CC0 Public Domain A team of investigators from Massachusetts General Hospital (MGH), Brigham and Women’s Hospital (BWH), and the Broad Institute of MIT and Harvard have developed a non-invasive genetic test that can screen the blood of pregnant individuals to survey all genes for fetal DNA sequence variants. The…

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Artificial Intelligence (AI) in Genomics Market to Surpass US$ 19.72 Billion by 2030

Copyright 2023 PR Newswire. All Rights Reserved2023-11-22 BURLINGAME, Calif., Nov. 22, 2023 /PRNewswire/ — According to Coherent Market Insights, Global Artificial Intelligence (AI) in Genomics market size was valued at US$ 1.15 Billion in 2023 and is expected to surpass US$ 19.72 Billion by 2030 and is anticipated to witness a compound…

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Phenotypic drug-susceptibility profiles and genetic analysis based on whole-genome sequencing of Mycobacterium avium complex isolates in Thailand

Abstract Mycobacterium avium complex (MAC) infections are a significant clinical challenge. Determining drug-susceptibility profiles and the genetic basis of drug resistance is crucial for guiding effective treatment strategies. This study aimed to determine the drug-susceptibility profiles of MAC clinical isolates and to investigate the genetic basis conferring drug resistance using…

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Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis | BMC Psychiatry

Tartt AN, Mariani MB, Hen R, Mann JJ, Boldrini M. Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications. Mol Psychiatry. 2022;27(6):2689–99. doi.org/10.1038/s41380-022-01520-y Article  CAS  PubMed  PubMed Central  Google Scholar  Friedrich MJ. Depression is the leading cause of disability around the World. JAMA. 2017;317(15):1517. doi.org/10.1001/jama.2017.3826 Article  PubMed …

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Medical Aesthetics Market Size Worth USD 43.2 Billion in

Vancouver, Nov. 22, 2023 (GLOBE NEWSWIRE) — The global medical aesthetics market size was USD 15.3 Billion in 2022 and is expected to register rapid revenue CAGR of 11.0% during the forecast period. Key factors propelling this growth include the increasing awareness of aesthetic procedures, a surge in the adoption…

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What Is CRISPR Technology | CitizenSide

History of CRISPR Technology The history of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology traces back to the early 1990s when scientists first noticed repetitive DNA sequences in the genomes of certain bacteria. However, it wasn’t until 2005 that the true potential of CRISPR was realized. It was in…

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New Breakthrough Enhances CRISPR Diagnostic Technology

Researchers at the University of Connecticut have made a significant breakthrough in improving the efficacy and efficiency of CRISPR diagnostic technology. Led by Professor Changchun Liu, the team has developed a new method that enhances the existing clustered regularly interspaced short palindromic repeats (CRISPR) technology, allowing for faster, more sensitive,…

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Misconceptions about artificial intelligence (AI)

Artificial intelligence (AI) is a term that often conjures up images of futuristic robots and machines taking over the world. However, Karmel Allison, a technical advisor to Microsoft’s CTO, Kevin Scott, offers a refreshing and insightful perspective on AI that challenges many of the common misconceptions surrounding this technology. With…

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Metagenomic Sequencing Market Forecasted 17.6% Growth Rate,

The Metagenomic Sequencing Market witnessed a significant global revenue of US$ 1.2 Billion in 2022. It is projected to experience a remarkable growth rate of 17.6% from 2023 to 2033, ultimately reaching a valuation of US$ 7.1 Billion by the conclusion of the forecast period. The Metagenomic Sequencing Market has…

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Q&A: How Artificial Intelligence Powers Collaboration and Efficiency for Healthcare

Artificial Intelligence plays a pivotal role in fostering collaborative efforts and boosting operational efficiency within the healthcare ecosystem, helping streamline complex processes and aiding in clinical decision-making. Among the chief applications for this technology are AI-driven diagnostic support systems, which assist healthcare professionals in interpreting medical images and…

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Geelong lab advances African Swine Fever vaccine

THE CSIRO’s Australian Centre for Disease Preparedness in Geelong has teamed up with US biotech firm MBF Therapeutics to evaluate a new DNA vaccine against African Swine fever. The deadly viral disease that’s hit Asia and reached Indonesia, Timor Leste, and Papua New Guinea, poses a major threat to the…

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Magnetic Beads Market Journey of Discovery Ethnography’s Influence on Consumer Behavior | Thermo Fisher Scientific, Advanced BioChemicals | Taiwan News

The “Magnetic Beads Market” is poised for significant growth from 2023 to 2032, with the market size projected to increase from USD Million in 2023 to USD Million by 2032, exhibiting a substantial Compound Annual Growth Rate (CAGR) during the forecast period. This report offers a comprehensive analysis of the market, including key trends, opportunities, recent…

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ARFID Genes and Environment (ARFID-GEN): study protocol | BMC Psychiatry

Dinkler L, Bryant-Waugh R. Assessment of avoidant restrictive food intake disorder, pica and rumination disorder: interview and questionnaire measures. Curr Opin Psychiatry. 2021;34(6):532–42. Article  Google Scholar  American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Publishing; 2013. Thomas JJ, Lawson EA, Micali N, Misra…

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Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder

Phenotype imputation increases effective sample size We focused on the deepest available measure of MDD in UK Biobank11, LifetimeMDD, which we derived by applying clinical diagnostic criteria in silico to MDD symptom data from the Patient Health Questionnaire 9 (PHQ9) and the Composite International Diagnostic Interview Short Form (CIDI-SF) in…

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After Updating R and RStudio message() function does display in console

I recently updated R (from 4.1.1 High Sierra) and RStudio (2021.09.0 +351) to R (4.3.2 “Eye Holes”) intel version and RStudio (2023.09.1 +494). Note: I did try the ARM version supporting the apple silicon m2 chip as well but reverted back to the intel version in case that was the…

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A Diagnosis of Maternal 22q Duplication and Mosaic Deletion following Prenatal Cell-Free DNA Screening

Concurrent microduplication and microdeletion of the chromosome 22q11.2 region are a rarely reported phenomenon. We describe a case of germline 22q11.21 microduplication syndrome with concurrent mosaic 22q11.2 deletion in a pregnant patient, identified by chromosomal microarray and FISH after noninvasive prenatal genetic screening (cfDNA) results discordant with family history. The…

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Blood plasma metagenomic next-generation sequencing for identifying pathogens of febrile neutropenia in acute leukemia patients

Febrile neutropenia is a serious condition that often affects patients with acute leukemia, compromising their immune system and leaving them highly susceptible to infections. Identifying the causative pathogens responsible for febrile neutropenia is crucial for appropriate and timely treatment selection6,7. The precise diagnosis of microbial infections and timely antibiotic therapy…

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Researchers Improve Efficacy and Efficiency of CRISPR Diagnostic Technology

Changchun Liu, professor of Biomedical Engineering at UConn Health, has developed a new method that improves existing diagnostic technology for a more rapid, sensitive, and deployable approach to molecular diagnostics. The research, published in Nature Communications, unravels new potential for simple and sensitive nucleic acid detection in various diagnostic settings—including…

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Report by Polaris Market Research

NEW YORK, Nov. 20, 2023 /PRNewswire/ — A latest research report [110+] pages with 360-Degree visibility, titled “Pharmacogenomics Technologies Market Share, Size, Trends, Industry Analysis Report, By Technology (PCR, In-situ Hybridization, Immunohistochemistry, Sequencing, Others); By Therapeutic Area; By Region; And Segment Forecasts, 2023 – 2032” published by Polaris Market Research in…

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Pharmacogenomics Technologies Market Size/Share Expected to Exceed USD 14.10 Billion By 2032, With 9.1% CAGR: Report by Polaris Market Research

NEW YORK, Nov. 20, 2023 /PRNewswire/ — A latest research report [110+] pages with 360-Degree visibility, titled “Pharmacogenomics Technologies Market Share, Size, Trends, Industry Analysis Report, By Technology (PCR, In-situ Hybridization, Immunohistochemistry, Sequencing, Others); By Therapeutic Area; By Region; And Segment Forecasts, 2023 – 2032” published by Polaris Market Research in…

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Universal DX Announces Strategic Collaboration with Quest Diagnostics to Bring Advanced Colorectal Cancer Screening Blood Test to Patients and Providers in the United States

UDX also announces the initial closing of its series B financing of approximately $70 million with investors, including Quest Diagnostics Financing to support UDX’s pursuit of FDA premarket approval for its colorectal cancer screening blood test CAMBRDIGE, Mass. and SECAUCUS, N.J., Nov. 20, 2023 /PRNewswire/ — Universal DX (“UDX”), a biotech…

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GLH Bioinformatics Lead at NHS in London

Professional Responsibilities Accountable for the day to day management and continuous improvement of the bioinformatics pipelines for data analysis and management of large datasets. Steer the development of bioinformatics systems and ensure systems across the consortium meet the technical requirements of the service, as well as any contractual obligations. Accountable…

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CircRNA in ocular neovascular diseases: Fundamental mechanism and clinical potential

Review doi: 10.1016/j.phrs.2023.106946. Epub 2023 Oct 4. Affiliations Expand Affiliations 1 Department of Ophthalmology, 2nd Hospital of Jilin University, Changchun 130041, Jilin, China. 2 Department of Ophthalmology, 2nd Hospital of Jilin University, Changchun 130041, Jilin, China; Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai…

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