Tag: DNA

Upload your DNA data from almost any genetic test. Easily upload DNA data from a broad spectrum of genetic tests to Sequencing.com, your central hub for genetic insights. From the moment your data is uploaded, you unlock access to an extensive selection of DNA analysis apps and reports, designed to transmute…

Get mRNA sequence from amino acid sequence using BioPython 1 I have a sequence of amino acids like “MVLLV” and I want to know what mRNA corresponds to that, I’m using biopython for this, but I just know the back_transcribe(), to revert the RNA to DNA, how can I do…

doi: 10.3897/BDJ.11.e91577. eCollection 2023. Affiliations Expand Affiliations 1 UMR Écologie des Forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRAE, Université de Guyane, Université des Antilles), Kourou, French Guiana UMR Écologie des Forêts de Guyane (AgroParisTech, CIRAD, CNRS, INRAE, Université de Guyane, Université des Antilles) Kourou French Guiana. 2 Laboratoire Evolution et…

Exploring the Viral Reservoir of HIV-1 The fight against HIV-1, the virus responsible for the global AIDS pandemic, hinges on understanding the virus’s reservoirs within the human body. A recent study delves into the longitudinal evolution of these viral reservoir cell pools, shedding light on their characteristics, behavior, and potential…

For this year’s women and girls in science day, UAR chose to highlight the career of a world-renowned scientist and how animal research shaped her path to becoming one of the most respected and revered researchers. Working in fundamental science and microbiology, Emmanuelle Charpentier gradually obtained prizes, eventually receiving one…

Moderate Mapping percentage 1 Hi all, I received my sequenced transcriptome and genomic data from my service provider and started working with it. Both the DNA and RNA data passed quality metrics post trimming. But the mapping percentage comes out to be 90% using bowtie-DNA and 85% using Hisat2-RNA. I…

Metagenomics is simply the study of microbes in the natural living environment that involves complex microbial communities where they exist. The study helps examine an organism’s genomic composition, including all its microbes. Rather than considering the concept of an organism and microbes as separate entities, regard them as a community…

Welcome to another blog post! ‍ Reference genomes are essential benchmarks of a species’ genome that facilitate the accurate comparison of individual genomes and are crucial tools for identifying genetic variants and diagnosing rare diseases. Here, we will explore the evolution of the human reference genome, focusing on the transition…

In a groundbreaking study, researchers at the Salk Institute and the University of California, San Diego have unveiled a novel mechanism that implicates improperly functioning mitochondrial DNA (mtDNA) in the activation of an inflammatory pathway. Chronic inflammation is a key contributor to various human diseases and aging, and understanding its…

Abstract Metagenomic binning, the process of grouping DNA sequences into taxonomic units, is critical for understanding the functions, interactions, and evolutionary dynamics of microbial communities. We propose a deep learning approach to binning using two neural networks, one based on composition and another on environmental abundance, dynamically weighting the contribution…

Scientists have discovered a new way in which misplaced mitochondrial DNA (mtDNA) can be a cause of inflammation, which may equip clinicians with the tools to use these diseases as therapeutic interventions against inflammation associated with aging and other diseases. Credit: SciTechDaily.com. Salk scientists show a pathway for mouse cell…

Inferring divergence times within pikas (Ochotona spp.) using mtDNA and relaxed molecular dating techniques. Inferring divergence times within pikas (Ochotona spp.) using mtDNA and relaxed molecular dating techniques. Mol Phylogenet Evol. 2009 Oct; 53(1):1-12. Animals Animals DNA, Mitochondrial …

In the realm of technology and computing, a groundbreaking development has been made. Researchers have successfully developed a processor using DNA, where a microfluidic chip can perform mathematical calculations and store data. This innovative approach to bio-computing demonstrates the immense potential that lies in DNA-based computing systems. The ability of…

(MENAFN– GlobeNewsWire – Nasdaq) The Global Bioinformatics Market was valued USD 10.23 Billion in 2023 and projected to reach USD 28.6 Billion by 2030, growing at a CAGR of 13.73% during the forecast period of 2023-2030 Richmond, Feb. 09, 2024 (GLOBE NEWSWIRE) — According to a research report ” Bioinformatics…

Abstract CRISPR-based high-throughput genome-wide loss-of function screens are a valuable approach to functional genetics and strain engineering. The yeast Komagataella phaffii is a host of particular interest in the biopharmaceutical industry and as a metabolic engineering host for proteins and metabolites. Here, we design and validate a highly active 6-fold…

In a groundbreaking study, researchers from the Salk Institute and the University of California San Diego have identified a new pathway used by cells to remove dysfunctional mitochondrial DNA (mtDNA) from within mitochondria. The discovery sheds light on how misplaced mtDNA triggers an immune response that promotes inflammation, opening up…

Placer County cold case gets big break thanks to advanced DNA technology Placer County cold case gets big break thanks to advanced DNA technology 02:13 APPLEGATE — A Placer County cold case just got a big break thanks to advanced DNA technology identifying a woman nearly 40 years after her…

Job DescriptionThis is a Pre-Fellowship for early career researchers wanting to establish a career in MND translational research and become MND research leaders of the future. The postholder will have a leading role in an exciting new project funded by Motor Neurone Disease Association and MND Scotland. The project is…

UV Radiation and Its Impact on Plant Genome Plants, as primary producers, rely on solar energy for photosynthesis, a vital process for their survival and growth. However, the UV component of solar radiation can impair genome stability in plants by creating DNA lesions known as UV photoproducts. These lesions hinder…

Introduction Short-read metagenomic sequencing is the technique most widely used to explore the natural habitat of millions of bacteria. In comparison with 16S rRNA sequencing, shotgun metagenomic sequencing (MGS) provides sequence information of the whole genomes, which can be used to identify different genes present in an individual bacterium and…

Endosomes (magenta) collect around mitochondria (blue) after infection with virus HSV-1, which attacks mtDNA (green) and causes its release. Credit: Salk Institute One of the ways our cells respond to damage and infection is with what’s known as the innate immune system. While the innate immune response is the first…

Mitochondrial DNA (mtDNA) encodes essential subunits of the oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the cytoplasm, outside of cells or into circulation. As a DAMP, mtDNA not only contributes to anti-viral resistance, but also causes pathogenic…

Executive Summary: WuXi AppTec, a major Chinese biotechnology and pharmaceutical firm, claimed that the company has not, does not, and will not pose a national security risk to any country in response to new legislation introduced in the US Congress. The company’s claims are undermined by WuXi Apptec’s network of…

Shondra Pruett-Miller, a biochemist at St. Jude Children’s Research Hospital, found her calling during her first year of graduate school at the University of Texas, Southwestern. In 2003, during the departmental faculty research talks, she watched with excitement as Matthew Porteus, now a biochemist at Stanford University, presented his research…

In a groundbreaking development, researchers from NYU Grossman School of Medicine have unveiled a novel technique called Long Range Cleavage sequencing (LORAX-seq). This innovative method can pinpoint the start and end of backtracking events in genetic material, offering unprecedented insights into the intricate world of genetics. Unraveling the Mysteries of…

Zaman, S. B. et al. A review on antibiotic resistance: Alarm bells are ringing. Cureus doi.org/10.7759/cureus.1403 (2017). Article  PubMed  PubMed Central  Google Scholar  Peterson, E. & Kaur, P. Antibiotic resistance mechanisms in bacteria: Relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front. Microbiol. 9, 2928 (2018)….

A Groundbreaking Discovery: New Mechanism of mtDNA Release Scientists have recently discovered a breakthrough pathway for the release of mitochondrial DNA (mtDNA) during Herpes Simplex Virus-1 (HSV-1) infection or mitochondrial transcription factor A (TFAM) deficiency. This novel mechanism, distinct from previously established ones, does not involve BAK, BAX, or VDACs,…

Provided by: genometools_1.6.5+ds-2_amd64 NAME gt-encseq-encode – Encode sequence files (FASTA/FASTQ, GenBank, EMBL) efficiently. SYNOPSIS gt encseq encode sequence_file [sequence_file [sequence_file …]] DESCRIPTION -showstats [yes|no] show compression results (default: no) -ssp [yes|no] output sequence separator positions to file (default: yes) -des [yes|no] output sequence descriptions to file (default: yes) -sds [yes|no]…

A breakthrough study by scientists at the Salk Institute and UC San Diego has discovered an innovative mechanism related to the removal of malfunctioning mitochondrial DNA (mtDNA) from mitochondria, which triggers an innate immune response leading to inflammation. This mechanism is now understood to play a critical role in aging…

The microbiota of the gut has an impact on bone mineral density (BMD) and osteoporosis, but the specific species involved and the underlying mechanisms remained largely unknown until now. A new study has found that Bacteroides vulgatus demonstrates a negative association with BMD, while serum valeric acid (VA) exhibits a…

Richmond, Feb. 09, 2024 (GLOBE NEWSWIRE) — According to a research report “Bioinformatics Market”, by tools Type (BLAST, BioPerl, InterMine, Others), Services (Genome Sequencing, RNA sequencing, Metagenomic Analysis, Epigenomic, Others), Application (Drug discovery, Personalized medicine, Preventive medicine, Transcriptions, Metabolomics, Gene therapy, Others) Sectors (Medical Biotechnology, Animal Biotechnology, Plant Biotechnology, Environmental…

JOB TITLE: Software Quality Engineer III – Bioinformatics LOCATION: Remote, USA PRIMARY RESPONSIBILITIES: Perform software verification, define and execute test cases and scenarios required for software quality assurance and regulatory compliance. Perform system analysis, assess risk, and develop strong test strategies by analyzing product design and technical specifications, and by…

The Science Newswise — CRISPR-Cas is a tool that allows scientists to make targeted changes to an organism’s DNA. This tool consists of two parts. The first is a microscopic substance called a nuclease Cas protein (e.g., Cas9) that can cleave DNA. The second is an RNA molecule (also called…

Precision Therapies For Targeted Results Precision therapies have always been the ultimate goal of medicine. Instead of drugs acting on multiple parts of the body, these therapies would only target one organ, one cell, or even one gene. In theory, not only would this be a lot more efficient, but…

Cho, C. et al. Haploinsufficiency of protamine-1 or-2 causes infertility in mice. Nat. Genet. 28, 82–86 (2001). Article  CAS  PubMed  Google Scholar  Oliva, R. Protamines and male infertility. Hum. Reprod. Update 12, 417–435 (2006). Article  CAS  PubMed  Google Scholar  Balhorn, R. The protamine family of sperm nuclear proteins. Genome Biol….

Fig 2. The cLAMP specificity of the design (left panel) and reference (right panel) primer set. The plasmid DNA (pDNA) containing 18S rRNA genes from both the P. falciparum S-type (PfS) and A-type (PfA) were utilized to confirm primer specificity. A-type 18S rRNA genes from other Plasmodium species were also…

image:  Endosomes (magenta) collect around mitochondria (blue) after infection with virus HSV-1, which attacks mtDNA (green) and causes its release. view more  Credit: Salk Institute LA JOLLA (February 8, 2024)—Cells in the human body contain power-generating mitochondria, each with their own mtDNA—a unique set of genetic instructions entirely separate from…

Entry 100782702         CDS       T01710                                  Symbol COX2 Name (RefSeq) cytochrome c oxidase subunit 2, mitochondrial   KO K02261   cytochrome c oxidase subunit 2 Organism gmx  Glycine max (soybean) Pathway gmx00190   Oxidative phosphorylation gmx01100   Metabolic pathways Brite KEGG Orthology (KO) [BR:gmx00001] 09100 Metabolism  09102 Energy metabolism   00190 Oxidative phosphorylation    100782702 (COX2) 09180 Brite Hierarchies  09182 Protein families: genetic information processing   03029 Mitochondrial biogenesis…

After analysing 5,000 E. coli infections in Norway and Great Britain during the period 2001-2017, the results leave us in no doubt. In 2005, scientists showed for the very first time that the use of various antibiotics coincided with the occurrence of serious bacterial infections that were resistant to the…

The Biopython logo Biopython is a set of tools for doing all sorts of genomics tasks: reading DNA and RNA, aligning sequences, analyzing similarities between sequences, and more. This is the second part in a series on analyzing coronavirus RNA with Python. Here we’ll install Biopython and use it to…

A groundbreaking study published in Nature Cancer has unveiled a novel approach to tumor treatment. By leveraging local intratumor delivery with electroporation of low levels of plasmids encoding molecules, researchers have discovered an antitumor effect that does not result in systemic toxicity. Upregulating MHC-I and PD-L1: The Keys to Unlocking…

Netherlands-based company announces the inaugural regeneration of strawberries from gene-edited individual cells. Hudson River Biotechnology (HRB), headquartered in Wageningen, The Netherlands, announced the first successful regeneration of strawberry plants from gene-edited single cells, utilizing its unique CRISPR technology known as TiGER. The berry industry is currently facing challenges, transitioning from…

Did a study just show that COVID-19 vaccines killed 14x more people than they saved?! Take a look at the viral claim, and find out what the facts really are!   Claim : COVID Vaccines Kill 14X More People Than They Saved! People are sharing an article (archive) by The…

With many exciting discoveries to make and new problems to solve, the biotechnology industry provides many career opportunities that could make a difference in people’s lives. So, if you are searching for a career in the field, we have listed five biotechnology careers that are currently in high demand, and…

At the end of 2023, the FDA approved Casgevy for sickle cell disease, its first approval for a therapeutic that used the genome editing tool clustered regulatory interspaced palindromic repeats (CRISPR) to specifically inactivate a human gene as a treatment for a genetic disease. While CRISPR-based gene therapies could potentially…

dataset posted on 2024-02-09, 02:43 authored by Bin Liu, Yanping Qi, Xiaowei Wang, Xin Gao, Yuan Yao, Lu Zhang Alkyladenine DNA glycosylase (AAG) is an essential enzyme responsible for maintaining genome integrity by repairing several DNA lesions damaged by alkylation or deamination. Understanding how it can recognize and excise the…

The antibody-drug conjugate (ADC) field is witnessing an expansion in the variety of conjugation techniques, linker chemistry, and payloads being used, moving beyond traditional tubulin inhibitors to include novel mechanisms of action. Investments in ADC research continue to grow, with significant funding rounds and acquisitions. For example, Novo Holdings’ $105…

BATU PAHAT: Three men were arrested following the discovery of the skeletal remains of a woman believed to be Mira Sharmila Samsusah, the single mother also known as Bella, who was reported missing more than a month ago. Batu Pahat OCPD Asst Comm Ismail Dollah said the three suspects, aged…

A team of researchers from the Broad Institute of MIT and Harvard have developed two new priming agents that could improve the sensitivity of liquid biopsies for cancer detection. Liquid biopsies are a minimally invasive way to detect cancer by analyzing cell-free DNA (cfDNA) in the blood. However, cfDNA is…

CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated protein) genome editing enables precise, targeted genetic modification of plants. To date, the genomes of several crops, including rice, tomato, corn, wheat, soybean, barley, potato, sorghum, apple, grapefruit, and orange, have been edited using CRISPR-Cas-based genome editing technology. The CRISPR system cuts not…

AM Normal cfgDNA-1Description: DNA is extracted and fragmented from a popular normal male cell line Dissolved in TE: Part Number: 601330011ug per vialSpiked in Plasma: Part Number: 60133501Pre-spiked with 125ng gDNA per 5mlAM Normal cfgDNA-2Description: DNA is extracted and fragmented from normal female cell line, PAM3005Dissolved in TE: Part Number:…

Frederick Sanger, famous British biochemist, was born on August 13, 1918 in Rendcomb, England. He came from a modest family, his father Frederick Sanger Senior being a general practitioner and his mother, Cicely Sanger, being an accomplished musician. Nevertheless, despite his humble origins, Sanger inherited the talent and intelligence that…

As mentioned above, compared to conventional electrodes, the microneedle-type electrodes exhibit better pain management and lower voltage requirements due to the microscale needle dimensions. To manufacture microneedle-type electrode devices with precise patterning and high yields, sophisticated manufacturing techniques are often utilized. Some of these techniques include laser-cutting, metallization, and semiconductor…

Single nucleus RNA-seq reveals cell type heterogeneity in human SNpc We sampled SNpc from post-mortem human brains of 15 sporadic Parkinson’s disease (PD) patients and 14 Control individuals (see Supplementary Table 1 for full pathology reports). Using a 10X Genomics Chromium platform, we performed single nucleus RNA-seq (snRNA-seq) on more than…

Identification of putative anti-crispr proteins using structural features To identify Acrs in phage genomes, we began by retrieving ~66.5 million proteins from Integrated Microbial Genomes Virus database (IMG/VR)37. We excluded large proteins because over 90% of known Acrs contain less than 200 amino acids38 (Fig. 1A, Supplementary Data 1). To reduce computational…

34 The algorithm, developed by researchers at the University of Trieste in collaboration with Genomics England, allows the level of tumor contamination to be measured, improving diagnosis and treatment. Enter the new Fanpage.it WhatsApp channel In the fight against cancer, the use of innovative analysis tools is emerging as a…

What are the applications of gene transfer in the treatment of various diseases?5 answersGene transfer has various applications in the treatment of different diseases. It can be used for gene therapy, where new genes are inserted into cancer cells to slow down their growth or induce cell death. Gene transfer…

In a study published in Science, researchers have developed a new method to improve the sensitivity of liquid biopsies by transiently reducing the clearance of cell-free DNA (cfDNA). CfDNA is DNA that has been released from cells into the bloodstream. It can be used to detect cancer, monitor disease progression,…

How is genetics useful for conservation?5 answersGenetics is useful for conservation in several ways. It allows us to understand and address the loss of genetic diversity in natural populations, which can contribute to extinction risk. Conservation genetics helps investigate the diversity, distribution, and function of genetic variation in populations of…

Using CRISPR, an immune system bacteria use to protect themselves from viruses, scientists have harnessed the power to edit genetic information within cells. In fact, the first CRISPR-based therapeutic was recently approved by the FDA to treat sickle cell disease in December 2023. That therapy is based on a highly…

Bacteria Strain Cori.ST1911 was isolated from fresh stool of 20-week-old C57/BL6J mice fed a HFD at the Animal Center of the West China Hospital of Sichuan University. Briefly, faecal particles were ground with a glass grinding rod and suspended in sterile phosphate-buffered saline (PBS). After gradient dilution, the suspension was…

Findings published in open-access journal Genome Medicine. IRVINE, Calif., Jan. 18, 2024 /PRNewswire/ — Helio Genomics, an AI-driven healthcare company specializing in diagnostics technology and test development for cancer detection, today announced that results from an important new research study have been published in the peer-reviewed journal, Genome…

Ch 13 Learning Objectives Section 13.1 1. Differentiate between the structures of DNA & RNA (Table 13.1, Fig 13.1) 2. Know the locations and functions of rRNA, mRNA, and tRNA (Table 13.2)  For now, you only need to know rRNA, mRNA, tRNA. We will learn the others in future…

This study aims to analyze the polymorphism of the myostatin (MSTN) gene in exon 1 at SNPc.111G>C (rs523392653) and SNPc.267G>A (rs383271508) on various beef cattle in Indonesia. A total of 136 DNA samples were analyzed in this study, consisting of 33 heads of Madura, 31 heads of PO, 36 heads…

Sen. Roger Marshall (R-Kan.) speaks on border security and Title 42 during a press conference at the U.S. Capitol in Washington on May 11, 2023. (Kevin Dietsch/Getty Images) It has been four years since patients sickened with unexplained pneumonia started appearing at hospitals in the central Chinese city of Wuhan. But…

Job Portal Postdoc/assistant professor in molecular biology and bioinformatics: Structural variations associated to circular DNA in cancer Department of Biology, Faculty of Science at University of Copenhagen is offering a position in molecular biology and bioinformatics for a Postdoc/assistant professor for the analysis of extrachromosomal circular DNA in 1 April…

Jan. 19, 2024 — Over 18 million people worldwide are annually diagnosed with cancer, with each case hiding many mutations in its genome. Understanding these mutations furthers cancer research, while also providing a deeper understanding to create possible cures, therapies and prevention strategies. The Triton Shared Computer Cluster at the…

 Cornell researchers have taken an important step toward harnessing CRISPR gene editing in “targeted, safe and potent” cancer treatment, according to Ailong Ke, professor of chemistry and chemical biology in the College of Arts and Sciences. The enzyme CRISPR-Cas3, one of many different CRISPR systems found naturally in the immune systems…

A jury in Austin, TX, awarded biotech firm Ravgen $57 million in damages in its patent infringement lawsuit against Natera. The jury agreed that Natera’s Panorama prenatal screening test infringes on the Columbia, MD-based Ravgen’s patent rights in cell-free DNA (cfDNA) technology, according to a Ravgen statement. Ravgen’s lawsuit, which…

DNA is the blueprint of life, but it is constantly under attack from various sources of damage. The DNA is constantly exposed to various sources of damage, such as UV rays, chemicals, or errors during replication. One of the most serious types of damage is a double-strand break, where both…

Recall the technique used to mutagenize a population of Chlamy cells. This involved; mixing cells with antibiotic resistance gene DNA, electroporation and plating the cells on an agar plate.  After 2 weeks, the agar plate is covered with 100s of individual colonies of cells. What statement about these 2…

Catalog number PVTB80045-3a Price 356 EUR Size 2 ug Kit Plasmid mini made and maxi DNA purification kits can be silica gel or anion exchange, endotoxin free and are used to produce pure plasmids that are small DNA molecules within a cell separated from chromosomal DNA and can replicate independently. They are most…

Option 2: Genetics is a rapidly evolving area of science. Each year, advances in genetics bring exciting new technologies to the market. Areas such as forensics, genealogy, and healthcare have all been affected by new genetic technologies. Choose a genetic technology and report on how this technology is affecting or…

The specific environmental/history/collection context The Huseby Klev materials were unearthed and collected by archaeologists (including two of the co-authors of this article) during the excavation of this coastal hunter-fisher-gatherer site in the 90s50. The material assemblage was rich and well preserved: human bones, animal bones, plant remains and pieces of…

Intravenous nanoparticle priming agents given hours before a blood draw greatly increase the sensitivity to liquid biopsies for detecting cancer, according to a preclinical study in mice. In these animals, the approach increased the sensitivity for detection of small tumors from 10% to 75%. “Just as iodinated and gadolinium contrast…

Animals and samples The study included 10 pigs, 8 pigs were bred at the INRAE experimental farm (doi.org/doi.org/10.15454/1.5572415481185847E12) and 2 pigs come from breeding organizations in accordance with the French and European legislation on animal welfare. The animals belong to the same family, except for one LW animal. Animals were…

Burgess HM, Depledge DP, Thompson L, Srinivas KP, Grande RC, Vink EI, Abebe JS, Blackaby WP, Hendrick A, Albertella MR, Kouzarides T, Stapleford KA, Wilson AC, Mohr I. Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication. Genes Dev. 2021;35:1005–19. Article  CAS  PubMed  PubMed Central  Google Scholar  Chambers…

The DR beta/BamHI system identified the 17 fragments listed in Table 1. Four of these (St. fragment nos. 2, 6, 13, and 16) were not included in the analysis (no locus assignment) as they were very faint and seen only on a few films. Possible reasons for these fragments could…

Gladyshev, V. N. et al. Molecular damage in aging. Nat. Aging 1, 1096–1106 (2021). Article  PubMed  PubMed Central  Google Scholar  Sziráki, A., Tyshkovskiy, A. & Gladyshev, V. N. Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction. Aging Cell 17, e12738 (2018). Article  PubMed …

“[…] mutational signatures are not only genomic noise of passenger mutations, but they provide etiological and biological information on carcinogenesis.” BUFFALO, NY- January 19, 2024 – A new editorial paper was recently published in Oncoscience (Volume 10), by researcher Peeter Karihtala from the University of Helsinki and University Hospital Comprehensive…

A few hours before the CASP14 (14th Critical Assessment of Structure Prediction) meeting, the latest biannual structure prediction experiment where participants build models of proteins given their amino acid sequences, this image went viral on twitter. Ranking of participants in CASP14, as per the sum of the Z-scores of their…

Description: The Computational Biology & Gene Regulation group led by Anthony Mathelier at the NCMM, a part of the Nordic EMBL Partnership for Molecular Medicine, is seeking a highly motivated Researcher or Postdoctoral Fellow for a two-year position, starting as soon as possible in 2024. The selected candidate will play…

Using CRISPR, an immune system bacteria use to protect themselves from viruses, scientists have harnessed the power to edit genetic information within cells. In fact, the first CRISPR-based therapeutic was recently approved by the FDA to treat sickle cell disease in December 2023. That therapy is based on a highly…

Natural killer (NK) cells are white blood cells that are a part of the body’s defense mechanism. These cells are on the lookout for any kind of disruption in the immune system, and can kill diseased cells like tumor cells. NK cells are being used in clinical applications to treat…

Troubleshooting RNA-seq data with DNA contamination 0 Hi everyone, If there has been DNA contamination in the RNA samples and RNA-seq was conducted. After RNA-seq, I tried using SeqMonk and I estimated contamination levels, which were highly variable between samples, ranging from 1.7% to 10.5%. My initial step was to…

Summary In May 1982, Kevin McBride, who was 47 at the time, was the victim of a homicide and died by multiple stab wounds inside his apartment at 311-5600 Sheppard Ave East. Officers were originally asked to attend Kevin’s residence by concerned friends who had dinner plans with him and…

Photo by Sangharsh Lohakare on Unsplash In the landscape of scientific advancement, the emergence of CRISPR technology has propelled humanity into a new era of genetic possibilities. While the revolutionary gene-editing tool offers unprecedented opportunities to reshape the blueprint of life, it also raises profound ethical dilemmas that echo through…

Hu T, Chitnis N, Monos D, Dinh A. Next-generation sequencing technologies: an overview. Hum Immunol. 2021;82(11):801–11. Article  CAS  Google Scholar  Jeon SA, Park JL, Park SJ, Kim JH, Goh SH, Han JY, Kim SY. Comparison between MGI and Illumina sequencing platforms for whole genome sequencing. Genes Genomics. 2021;43(7):713–24. Article  CAS …

Growth Plus Reports Pune, Jan. 08, 2024 (GLOBE NEWSWIRE) — According to the latest report published by Growth Plus Reports, the global Restriction Enzyme Market is expected to clock US$ 647.41 million by 2031 and to grow at a CAGR of 5.7% during the forecast period. The Restriction Enzyme Market…

Background: Thrombin is a serine protease and hemostasis regulator with multiple functions and recognized as an important biomarker for diseases, and sensitive detection of thrombin is of significance for clinical diagnostics and disease monitoring. Recently, the target-triggered nonspecific single-stranded deoxyribonuclease activity of CRISPR/Cas system is discovered, making it become a…

Less than 15% of the global population lives in Europe or North America. Yet more than 70% of published human microbiome data — on the collections of bacteria, fungi and viruses that live on and in our bodies — comes from European and North American populations1. Around 85% of the…

This protocol enables the impact of prophages on their hosts to be revealed. Bacterial cultures are synchronized using conditions that best support the lysogenic state, limiting spontaneous induction. RT-qPCR unequivocally distinguishes prophage-restricted genes and those uncoupled from phage control from those that are expressed during the lytic replication cycle. Prophages…

Background: Circulating cell-free DNA (cfDNA) has been widely used as a new liquid-biopsy marker. Dysregulation of cfDNA has been found in patients with systemic lupus erythematosus (SLE). However, the detailed association between cfDNA and SLE has not been thoroughly studied. Methods: Plasma samples were collected from 88 patients with active…

Background: MicroRNA-21 has been determined to be the only microRNA overexpressed in 11 types of solid tumors, making it an excellent candidate as a biomarker for disease diagnosis and therapy. Photoelectrochemical (PEC) biosensors have been widely used for quantification of microRNA-21. However, most PEC biosensing processes still suffer from some…

It said staff at the Taixing People’s Hospital submitted the genetic sequence to the GenBank sequence database, an open access collection maintained by the National Centre for Biotechnology Information in the United States. In December, the US centre said the nucleotide sequence present in the sample had not been detected…

Pune, Jan. 08, 2024 (GLOBE NEWSWIRE) — According to the latest report published by Growth Plus Reports, the global Restriction Enzyme Market is expected to clock US$ 647.41 million by 2031 and to grow at a CAGR of 5.7% during the forecast period. The Restriction Enzyme Market is witnessing significant…

The dream of a cancer vaccine — capable of stimulating the immune system to fight tumors — is on the horizon of the scientific community. It probably has never been as close as it is now. After years of few successes in this field, the consolidation of other immunotherapies and…

On Friday, wastewater data from Biobot Analytics and the US Centers for Disease Control and Prevention (CDC) affirmed that the US has now reached its second-highest level of COVID-19 infections of the pandemic. It is anticipated that by midweek, rates of infections will reach 2 million per day with approximately…

Kevin Kavanagh  |  Opinion Contributor The COVID-19 deniers are being faced with a new reality, that of long COVID, and no amount of disinformation on how COVID is not dangerous can make this danger go away. Xie and colleagues documented that long COVID is more dangerous than the flu. And…

The OECD recently published an update on key biotechnology indicators, an opportunity for us to delve into the top-performing countries in the field. With the highest number of active biotech companies (2,840) and an R&D intensity added value of 17%, the U.S. remains a strong leader in the industry. But…