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Tag: DNA
Revolutionizing acne treatment with CRISPR technology
Eligo Bioscience is a gene-editing company focused on addressing diseases driven by the expression of bacterial genes from the microbiome, and in its crosshairs, initially, is moderate to severe acne vulgaris, an inflammatory disease that affects about 3% of the global population. This week, we talk to Xavier Duportet, CEO…
Incredible Inventions: Innovations That Changed The World
By Sophia Maddox | January 1, 2024 Discover the World Using GPS Welcome to a world where imagination knows no bounds and human ingenuity has the power to reshape the course of history. It’s a world where creativity and innovation are the driving forces, pushing the boundaries of what was…
IKK gamma (IKBKG) Human shRNA Plasmid Kit (Locus ID 8517)
Product Data Locus ID 8517 Synonyms AMCBX1; EDAID1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9 Vector pGFP-C-shLenti E. coli Selection Chloramphenicol (34 ug/ml) Mammalian Cell Selection Puromycin Format Lentiviral plasmids Kit Components IKBKG – Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene…
Crispr Library Download
CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibCas9) by mining existing large-scale gene loss-of-function datasets, resulting in a greater than 42% reduction in size compared…
cfDNA Extraction Sensitivity Controls – cfDNA Extraction Sensitivity Controls
Does your cfDNA extraction process affect the Limit of Detection (LOD) of a particular gene target? Our new products, cfDNA Extraction Sensitivity Panels and Extraction Low Positive Controls, can help your research and development for liquid biopsy assays. NEW PRODUCTS: cfDNA EXTRACTION SENSITIVITY PANELS & CONTROLS The Extraction Sensitivity Controls…
Uyghur genetic data paper retracted for ethics
There are growing worries that academic publishers might not do enough to check that published research adheres to ethical standards. This is in response to the retractions of a 2019 study that used Xinjiang blood and saliva samples to analyze genetic data from Uyghur and Kazakh populations. Elsevier withdrew the…
German Bundestag – No undesirable effects from DNA fragments
39 Berlin: (hib/PK) According to the federal government, there is no scientific evidence that the DNA fragments contained in anti-corona vaccines could cause undesirable effects. Every active ingredient batch of the Covid-19 mRNA vaccine is mandatory tested by the manufacturer for residual DNA amounts. The results are part of the…
HPV DNA testing proven effective in cervical cancer prevention – myRepublica
KATHMANDU, Jan 1: Cervical cancer claims the lives of many women prematurely, but a simple test can be a lifesaver—the HPV DNA test. This test detects the presence of the Human Papillomavirus (HPV), which is the cause behind cervical cancer. Doctors say that if the Human Papillomavirus (HPV) is detected…
Test could identify more cancer patients eligible for immunotherapy
Revising current testing guidelines so that a more sophisticated test could be used more often would enable 6,000 more people in the United States to receive immunotherapy, researchers say. Photo by Adobe Stock/HealthDay News More patients could benefit from immunotherapy, a highly effective treatment for some cancers, new research suggests….
Resurrection Biology’ Gains Momentum As Scientists Explore Bringing Life Back from the Past
The field of “resurrection biology” is gaining prominence across the globe, as scientists embark on endeavors to revive elements of the past. This scientific pursuit, although far from the fictional genetically engineered dinosaurs of “Jurassic Park,” encompasses a range of research objectives. What Resurrection Biology Entails Credit: DepositPhotos Science studies…
Study sheds more light into benefits of immunotherapy
According to the Brigham researchers’ next-generation sequencing, changing existing cancer care standards might allow around 6,000 more patients in the United States to benefit from immunotherapy treatment each year. Immunotherapy is a highly successful treatment for cancer patients with mismatch repair failure, and new research finds additional cancer patients…
What is 16s rRNA sequencing?
What are the limitations of using 16S sequencing for taxonomic identification?4 answers16S sequencing for taxonomic identification has several limitations. The most commonly used bioinformatics tools, such as Qiime 2 and Mothur, may underestimate the accuracy of species-level taxonomic assignments. Additionally, current analytical approaches lack the ability to formalize syntheses of…
Streamline Assay and Sequencing Workflows
Automated liquid handlers have become a common feature in laboratories as researchers look to increase efficiency, accuracy, and precision across applications. Though there is a wide range of automated liquid handling systems from automated simultaneous pipettors to full robotic systems to suit virtually any application, this variety can make it…
Guide to Electroporation and_
基本信息 · 书名:Guide to Electroporation and Electrofusion · 作者:Chang · ISBN13:9780121680411 · 装帧:平装 · 语种:英文 · 出版日期:1991-12-01 · 出版社:Academic Press · 页数:569 · 重量:0.9 kg · 尺寸:23 x 15.3 x 3.7 cm * 页面参数仅供参考,具体以实物为准. —— 书籍简介 —— Electroporation is an efficient method to introduce macromolecules such as DNA into a wide…
Genetic Technologies and BioVie Interviews to Air on the RedChip Small Stocks Big Money(R) Show on Bloomberg TV
ORLANDO, FL / ACCESSWIRE / December 29, 2023 / RedChip Companies will air interviews with Genetic Technologies Limited (NASDAQ:GENE) and BioVie, Inc. (NASDAQ:BIVI) on The RedChip Small Stocks Big Money® Show, a sponsored program on Bloomberg TV, this Saturday, December 30, at 7 p.m. Eastern Time (ET). Bloomberg TV is…
Health Ministry: Jordan Free Of GN.1 Covid-19 Subvariant
(MENAFN– Jordan News Agency) Amman, Dec 30 (Petra) — Jordan is free of the rapidly spreading Covid-19 subveriant GN.1, Health Ministry Secretary-General for Primary Health Care Raed Shboul announced Saturday.He said a DNA sequencing found that the Kingdom is free of the subvariant and that not a single infection was…
TCW’s Top Twenty: Why I don’t believe there ever was a Covid virus
As we approach the end of the year, we are repeating our twenty most-read articles of 2023, in reverse order. This is number 2 and it was first published on March 22. I’VE grown increasingly frustrated about the way debate is controlled around the topic of origins of the alleged…
Building the taxonomic profile of the Riniaie Marwah hot spring of Kishtwar in Jammu and Kashmir: the first high-throughput sequencing-based metagenome study
Background and objectives: Rinaie Marwah hot spring Kishtwar (RMHSK) is one of the geothermal springs located at 33°51’51″N 75°32’07″E with an elevation of 2134 meters above sea level in Jammu and Kashmir, India. We aimed to study the microbial diversity of this geothermal spring using metagenomics. Materials and methods: In…
Understanding DNA Sequence Alignment using C++ Code | by Shriya Paturu | Dec, 2023
Introduction: DNA sequence alignment is a fundamental technique in bioinformatics used to compare and analyze genetic sequences. In this article, we’ll explore a C++ implementation of a basic DNA sequence alignment algorithm, shedding light on its significance and applications in biological research. Background: DNA sequencing is a technique used to…
Electroporation as a cutting edge technique shaping the future of food processing. Comment on: “Advances in pulsed electric stimuli as a physical method for treating liquid foods” by Farzan Zare, Negareh Ghasemi, Nidhi Bansal, Hamid Hosano
Abstract Electroporation, also known as electropermeabilization or electrostimulation, is the process of using pulsed electric fields (PEF) to create temporary pores in the cell membranes of biological tissues. By applying specific electrical pulses, the cell membrane’s permeability is increased, allowing the entry or exit of ions, molecules, and other compounds…
Is Australia Opportunistically Vaccinating People Under Sedation?!
Is Australia opportunistically vaccinating people under sedation?! Take a look at the viral claims, and find out what the facts really are! Claim : Australia Is Opportunistically Vaccinating People Under Sedation! People are sharing an ATAGI advisory, while claiming or suggesting that Australia is opportunistically vaccinating people under sedation!…
ZCWCC1 (MORC2) Human shRNA Lentiviral Particle (Locus)
Product Data Locus ID 22880 Synonyms CMT2Z; DIGFAN; ZCW3; ZCWCC1 Vector pGFP-C-shLenti Format Lentiviral particles RefSeq NM_001303256, NM_001303257, NM_014941, NM_014941.1, NM_014941.2, NM_014941.3, NM_001303257.1, NM_001303257.2, NM_001303256.1, NM_001303256.2, BC019257, BC136782, BC141657, BM683680, NM_001303256.3 UniProt ID Q9Y6X9 Summary This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is…
Behind the exoneration of Australian woman convicted of killing her children
On December 14, Kathleen Folbigg’s 2003 convictions for murder of three of her infant children and manslaughter of the fourth was quashed by the New South Wales Court of Criminal Appeal in light of the Report of the 2022 Inquiry into the convictions of Kathleen Megan Folbigg delivered in November…
Low dose ribosomal DNA P-loop mutation affects development and enforces autophagy in Arabidopsis
Arabidopsis contains hundreds of ribosomal DNA copies organized within the nucleolar organizing regions (NORs) in chromosomes 2 and 4. There are four major types of variants of rDNA, VAR1–4, based on the polymorphisms of 3’ external transcribed sequences. The variants are known to be differentially expressed during plant development. We…
European Mouse Mutant Cell Repository
The following list defines the different statuses that EUCOMM report on the constructs in their pipeline. Mice – Genotype confirmed (M-GC)The genotype of testcross offspring has been confirmed molecularly. Mice – Germline transmission (M-GLT)Test crosses of chimaeras indicate germline transmission of the ES cell mutation based on coat color. Mice…
Pharmaceutics | Free Full-Text | Natural Biopolymer-Based Delivery of CRISPR/Cas9 for Cancer Treatment
Cancer is one of the leading causes of disease-associated mortality, with a rising incidence worldwide [1]. Although many therapeutic methods have been used in cancer treatment, such as chemotherapy, radiotherapy, surgery, and targeted therapy, the overall therapeutic outcome remains unsatisfactory. Therefore, developing new therapeutic means is urgently needed. With advances…
The Science Behind It: Metagenomics 101
If microorganisms are invisible to the naked eye, how do we know anything about them? Generally, there are 3 common ways to identify microbes living in a given environment. The first is microscopy – looking at microbes under a microscope. There are only a few different shapes that microbes can…
Double Stranded DNA (dsDNA) (Nuclear Marker) – CloneID – DSD/958
Double Stranded DNA (dsDNA) (Nuclear Marker) – CloneID – DSD/958 | Scientist.com Skip to Main Content Go to Main Navigation Details Gene ID: Not Applicable Uniprot: Not Applicable Gene Name: Not Applicable Applications: IHC Species Reactivity: Human Clonality: Monoclonal Host: Mouse Clone ID: DSD/958 Protein Target: Not Applicable Supplied As:…
Early prognosis prediction in acute myeloid and acute lymphoid Leukaemia patients by cell free DNA (cfDNA) Concentration Ratios
1Indian Council of Medical Research (ICMR), India 2Vardhman Mahavir Medical College & Safdarjung Hospital, India The final, formatted version of the article will be published soon. Notify me Receive an email when it is updated You just subscribed to receive the final…
Cadmium linked to DNA damage and morphological changes caused by particulate matter
Particulate matter causes health problems for those who inhale the fine droplets and particles, but the chemical composition of the mixture matters-;and can vary widely across space and time. Lydia Contreras and colleagues characterize the consequences of varying levels of exposure to three chemically distinct particulate matter mixes, sourced from…
Vaccines | Free Full-Text | Immunogenic Effects and Clinical Applications of Electroporation-Based Treatments
Immunotherapy can now be regarded as an attractive approach for cancer and infectious disease treatments. A variety of novel and varied therapeutic approaches are being discovered through immunology research. Among them, some treatment strategies are based on electrotransfer, also called electroporation (EP). EP is an efficient and safe method that…
The best biotech movies to watch this winter
It’s the holiday season, and what’s better to do than cuddle up in bed and watch a movie? We want to make sure you’re not missing out on some binge-worthy biotech movies this December. So, we have created a watchlist just for you. Here are some biotech movie recommendations to…
Can sf3b1 mutation be detected by rflp method?
Can sf3b1 mutation be detected by ARMS-PCR method?5 answersSF3B1 mutations can be detected using the ARMS-ddPCR method, which combines the amplification refractory mutation system (ARMS) with droplet digital polymerase chain reaction (ddPCR). This method allows for the detection of gene mutations at specific sites, including SF3B1 mutations, with high sensitivity…
Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice.
Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice. Publication , Journal Article Bartz, RR; Suliman, HB; Fu, P; Welty-Wolf, K; Carraway, MS; MacGarvey, NC; Withers, CM; Sweeney, TE; Piantadosi, CA Published in: Am J Respir Crit Care Med RATIONALE: Damage to mitochondrial DNA…
A potential savior for aging cartilage and osteoarthritis
A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 15, Issue 23, entitled, “Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes.” While advanced age is widely recognized as the greatest…
High-sensitivity two-color detection of double-stranded DNA with a confocal fluorescence gel scanner using ethidium homodimer and thiazole orange
High-sensitivity two-color detection of double-stranded DNA with a confocal fluorescence gel scanner using ethidium homodimer and thiazole orange – Texas A&M University (TAMU) Scholar Search form Overview Research Identity Additional Document Info Other View All Overview abstract Ethidium homodimer (EthD; lambda Fmax 620…
Neutrophil extracellular trap-induced intermediate monocytes trigger macrophage activation syndrome in adult-onset Still’s disease | BMC Medicine
Wang MY, Jia JC, Yang CD, Hu QY. Pathogenesis, disease course, and prognosis of adult-onset Still’s disease: an update and review. Chin Med J (Engl). 2019;132(23):2856–64. Article CAS PubMed Google Scholar Feist E, Mitrovic S, Fautrel B. Mechanisms, biomarkers and targets for adult-onset Still’s disease. Nat Rev Rheumatol. 2018;14(10):603–18. Article …
Horses drove societal transformation in South America – study
Horses on Argentina’s Valdes Peninsula. Photo by Cynthia del Río The introduction of horses to South America led to a rapid social and economic transformation, researchers report. “Perhaps nowhere in the ancient world was the impact of domestic horses on human societies more impactful than in the plains and foothills…
DNA Sequencing May Unlock the Future of Digital Storage | Washington D.C. & Maryland Area
Storage devices such as hard drives and solid-state drives don’t last forever. They are fragile, challenging to maintain, and can become obsolete quickly, causing considerable harm and loss if a device becomes unusable. Further, as data creation will soon outpace the amount of available storage space, new digital storage options…
Team Leader Bioinformatics – Ryvu Therapeutics, Krakow
Team Leader Bioinformatics – Ryvu Therapeutics, Krakow Team Leader Bioinformatics Ryvu Therapeutics Krakow, Poland As Bioinformatics Team Leader you will be responsible for development of this area within Data Science department which includes managing and growing the team, setting and executing short and long term plans, propagating collaboration with other…
In-Depth Analysis of MOTS-c Peptide
There are 37 known genes in mitochondrial DNA (mtDNA) that code for components of the electron transport chain (ETC) complexes; these genes include 2 ribosomal RNAs (rRNAs), around 22 transfer RNAs (tRNAs), and 13 polypeptide components. New studies have suggested that rRNA regions include tiny open reading frames (ORFs) that…
Anavex Life Sciences (AVXL) Announces First Entire Clinical Gene Pathway Data of ANAVEX2-73 from AVATAR Study in Patients with Rett Syndrome
Anavex Life Sciences Corp. (“Anavex” or the “Company”) (Nasdaq: AVXL), a clinical-stage biopharmaceutical company developing differentiated therapeutics for the treatment of neurodegenerative and neurodevelopmental disorders including Alzheimer’s disease, Parkinson’s disease, Rett syndrome and other central nervous system (CNS) diseases, today announced the first entire clinical gene pathway data from the…
ICR study increases understanding of advanced breast cancer complication
Researchers at the Institute of Cancer Research (ICR) have increased the understanding of a complication of advanced breast cancer which could help to develop effective treatments. Researchers implanted patients’ breast cancer leptomeningeal metastasis (BCLM) cells into mice to create models of the disease to advance research into the secondary form…
Science and Society Bacteria: hunting microscopic giants
MOST people will primarily associate protein with its role as a major food group. But at a cellular level, there are millions of possible proteins: they are large, complex molecules that play crucial roles in biochemical processes. A single protein molecule is made up of amino acids linked together in…
How did a man born 2,000 years ago in Russia end up dead in the U.K.? DNA solves the mystery.
A man born 2,000 years ago in Russia ended up buried in England — and researchers think they’ve finally figured out how, thanks to DNA. Scientists from London’s Francis Crick Institute, Durham University in England, and MOLA Headland Infrastructure, a consortium of two U.K. archaeology companies, worked together to determine…
Association of PIK3CA Mutation With Pathologic Complete Response and Outcome by Hormone Receptor Status and Intrinsic Subtype in Early-Stage ERBB2/HER2-Positive Breast Cancer | Oncology | JAMA Network Open
Key Points Question What is the association of PIK3CA mutations, response to therapy, and outcome by hormone receptor (HR) status and intrinsic subtype among patients with ERBB2/HER2-positive early breast cancer (EBC) treated in a clinical trial? Findings In this cohort study of 184 patients enrolled in the phase 3 trial…
GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners
doi: 10.1093/nar/gkad1202. Online ahead of print. Nidhi Kanwal 1 , Nicolai Krogh 2 , Indira Memet 1 , Nicolas Lemus-Diaz 1 , Chairini C Thomé 1 , Luisa M Welp 3 4 , Athanasia Mizi 5 , Philipp Hackert 1 , Argyris Papantonis 5 , Henning Urlaub 3 4 6 7 , Henrik Nielsen 2 , Katherine…
Achievements, accolades highlight past year at VUMC | VUMC Reporter
Editor’s note — the following is a roundup of the news that made headlines at Vanderbilt University Medical Center in 2023. Whole-genome sequencing agreement Nashville Biosciences LLC, a wholly owned subsidiary of Vanderbilt University Medical Center, and Illumina Inc., a global leader in DNA sequencing and array-based technologies,…
How MRD Testing Can Help
MRD testing is incredibly valuable in informing clinical decision-making in the treatment of lymphoid malignancies, and its adoption by all oncologists is crucial in the era of precision medicine. During my 10 plus years of practicing medicine, I have seen the blood cancer treatment landscape transform, as the development of…
Research reveals man born thousands of miles to the east traveled to Cambridgeshire 2,000 years ago
Archaeologists excavate the Offord Cluny 203645 burial. Credit: MOLA Headland Infrastructure Scientists from the Francis Crick Institute, Durham University, and MOLA Headland Infrastructure have discovered that a man who lived between AD 126–228 during the Roman period did not originally come from a rural farmstead near where he was buried,…
Data Scientist / Bioinformatician, Biologics R&D Job
Job Description 6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients. The Biologics Center (NBC) is accommodated within the Novartis Institutes…
Accurate detection of identity-by-descent segments in human ancient DNA
Ethics No new aDNA data were generated for this study and we only analysed previously published and publicly available aDNA data. Identifying biological kin is a standard analysis in the aDNA field. Permission for aDNA work on the archaeological samples was granted by the respective excavators, archaeologists, curators and museum…
Exploring the Latest Advances in Transcriptomics
Since the idea of genetic regulation was first postulated back in the 1950s, our scientific understanding of the transcriptome has deepened greatly.1 Looking into the transcriptome of cells and tissues has helped scientists to understand the biological processes that drive both health and disease; however, the complex and occasionally mysterious…
14 Simple, Effective Ways Companies Can Trim Their Technology Budgets
getty In a challenging economy, businesses and their teams are seeking ways to cut costs, and that includes what they spend on technology. New tools and systems have opened up unprecedented possibilities for streamlining processes and saving money. Still, the pursuit of a “comprehensive” tech stack can come with unexpected…
[Analysis of the feasibility and prognostic value of circulating tumor DNA monitoring in detecting gene mutations in patients with diffuse large B-cell lymphoma receiving chimeric antigen receptor T-cell therapy]
Objective: To explore the prognostic value of circulating tumor DNA (ctDNA) testing in patients with refractory/relapsed diffuse large B-cell lymphoma (R/R DLBCL) undergoing chimeric antigen receptor T-cell (CAR-T) therapy, and to guide the prevention and subsequent treatment of CAR-T-cell therapy failure. Methods: In this study, 48 patients with R/R DLBCL…
Enhancement and inactivation effect of CRISPR/Cas12a via extending hairpin activators for detection of transcription factors
Li Q, Song ZL, Zhang YX, Zhu LN, Yang Q, Liu XF, Sun XF, Chen XX, Kong RM, Fan GC, Luo XL (2023) Synergistic Incorporation of two ssDNA activators enhances the trans-cleavage of CRISPR/Cas12a. Anal Chem 95:8879–8888 Article CAS PubMed Google Scholar Ma JY, Wang SY, Du YC, Wang DX,…
3 futuristic ways ultrasound is revolutionising healthcare
Nobody likes the process of getting vaccinated, particularly young children, some of whom are terrified of needles. But research presented in Sydney earlier this month opens the door to a painless alternative – one whose primary downside might be that it’s actually a bit boring. And that’s just one way…
Researchers look for ways to lower neuroinflammation
Share on PinterestResearchers are looking for more effective ways to deliver a potential therapy against neuroinflammation to the brain. Image credit: Maskot/Getty Images. Small interfering RNAs can silence the machinery that translates certain mRNAs, meaning they can also be used to stop the production of some proteins. Researchers have looked…
MAIA Biotechnology Announces Dose Selection in THIO-101 Phase 2 Clinical Trial for Non-Small Cell Lung Cancer
CHICAGO, December 19, 2023–(BUSINESS WIRE)–MAIA Biotechnology, Inc., (NYSE American: MAIA) (“MAIA” or the “Company”), a clinical-stage biopharmaceutical company developing telomere-targeting immunotherapies for cancer, today announced dose selection for THIO-101, a Phase 2 clinical trial evaluating its lead asset, THIO, in sequential combination with Regeneron’s anti-PD-1 cemiplimab (Libtayo®) in patients with…
Apoptosis-resistant megakaryocytes produce large and hyperreactive platelets in response to radiation injury | Military Medical Research
Animals C57BL/6-Tg (Pf4-icre) Q3Rsko/J (Pf4-Cre) mice were purchased from the Jackson Laboratory (Bar Harbor, ME, USA). B6;129-Tmem173tm1(flox)Smoc (Stingfl) mice were purchased from Shanghai Model Organisms Center, Inc. (Shanghai, China). C57BL/6J-Ifnar1em1(flox)Cya (Ifnar1fl) mice were purchased from Cyagen Biosciences (Guangzhou, China). Stingcko and Ifnar1cko mice were generated by crossing Pf4-Cre mice with…
Summary of Genomics and Transcriptomics – DNA sequencing I. Goal II. Methodology A. Sanger DNA
DNA sequencing I. Goal II. Methodology A. Sanger DNA sequencing ● Up to 900 base pairs ● Primer extension with labeled ddNTPs (radioactive or fluorescent) ● Prior knowledge on target needed ● Difficult to detect variation in mixtures ● High accuracy + still in use for genotyping When it is…
Research spotlight: Structural analysis and i
Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions….
Genetic Testing Market Size Is Surpassing USD 44.3 Billion by 2032, Growing at Projected 9.8% CAGR
The Brainy Insights Global genetic testing market size from USD 17.4 billion in 2022 to USD 44.3 billion in 10 years. The rising prevalence of genetic diseases drives the market’s growth. Well-established healthcare system and the government’s provision of research funding are further elements expected to support market expansion. Newark,…
Vulnerabilities Behind Cancer’s “Death Star” Protein Revealed
Researchers at the Centre for Genomic Regulation in Barcelona, Spain, and the Wellcome Sanger Institute have comprehensively identified the allosteric control sites found in the protein KRAS. These are highly sought after targets for drug development, representing secret vulnerabilities, which can be exploited to control the effects of one of…
DNA Breakthrough: Body Found in 1999 Kentucky Lake Identified as Fugitive Accused of Rape
Kentucky State Police have identified remains found in Lake Barkley nearly 24 years ago as rape suspect Roger Dale Parham. (Kentucky State Police) The body of a man hauled in from a Kentucky lake 24 years ago has now been identified by police as a suspected rapist. Two fishermen found…
Charles River’s (CRL) Memphis Site Achieves Crucial Approval
Charles River Laboratories International, Inc. CRL recently achieved an important milestone in its strategic collaboration with Vertex Pharmaceuticals to manufacture CASGEVY (exagamglogene autotemcel [exa-cel]). The company’s Memphis facility has been approved to manufacture Vertex’s CASGEVY — the first-ever gene-edited therapy in the world that targets severe sickle cell disease (SCD)….
Seroprevalence and Molecular Characterization of B. abortus
Introduction Brucellosis is a zoonotic disease caused by Brucella spp., a gram-negative facultative intracellular coccobacillus.1 These microorganisms can infect livestock, wildlife, and humans, causing significant public concern and substantial agricultural economic loss. Currently, at least six novel Brucella species have been identified: Brucella pinnipedialis, Brucella ceti,2 Brucella papionis,3 Brucella microti,4…
Secret vulnerabilities of cancer’s ‘Death Star’ revealed
The study presents the first complete control map for any protein and was published on 18 December in the journal, Nature. KRAS is one of the most frequently mutated genes in cancers of many types. It is found in one in 10 human cancers, with higher prevalence in deadly types…
AQTUAL NAMES GREGG C. FERGUS TO ITS BOARD OF DIRECTORS
– The announcement follows the company’s groundbreaking clinical data presented at the American College of Rheumatology annual meeting HAYWARD, Calif., Dec. 19, 2023 /PRNewswire/ — Aqtual, a precision medicine company with a novel cfDNA platform to aid in treatment decisions for chronic diseases and cancers through a simple blood test,…
DNA Analysis: DNA analysis of severed body parts at Regional Forensic Science Laboratory (RFSL) | Nagpur News
Nagpur: DNA analysis of severed body parts is underway at a war-footing at the Regional Forensic Science Laboratory (RFSL) to identify the nine victims who were killed in a high explosive TNT blast at the Solar Industries India Limited at Kondhali, around 50 km from Nagpur, on Sunday.The analysts are…
India reports new Covid variant
With an uptick in the number of new cases and the confirmation of a new JN.1 strain of Covid-19 circulating in India, health authorities in Nepal say they are closely following developments in the southern neighbour. Even though Nepal has not seen a new surge of coronavirus cases, surveillance measures…
Revolutionizing sugarcane breeding: The emerg
Sugarcane, a crucial worldwide food and bioenergy crop, accounts for approximately 80% of the world’s sugar production, with its largest cultivation in Brazil and India. As the 5th largest crop by production value and acreage, it presents unique breeding challenges due to its complex polyploid genome, derived from interspecific hybridization….
1979 Las Vegas cold case victim identified as missing Ohio woman
LAS VEGAS (KTNV) — Las Vegas police and Othram have identified the body of a victim who was killed in 1979. According to the Las Vegas Metropolitan Police Department, on Aug. 14, 1979, a man walking through an open field near Sahara Avenue and Las Vegas Boulevard spotted a woman…
Progress of circRNA/lncRNA-miRNA-mRNA axis in atrial fibrillation [PeerJ]
Introduction The incidence and mortality rates of AF are continuously increasing, leading to serious complications such as heart failure and stroke (Fig. 1) (Sagris et al., 2021). The occurrence and development of AF involve different mechanisms and interactions (Kornej et al., 2020). AF often progresses from paroxysmal to persistent (Nattel…
Molecular characterization of a tetra segmented ssDNA virus infecting Botrytis cinerea worldwide | Virology Journal
Analysis of the multisegmented nature of BcssDV1 genome B. cinerea field isolates were previously obtained from infected grapes of vineyards of Italy and Spain and their mycovirome was determined [8]. A new ssDNA virus (BcssDV1, Genbank accession no. MN625247) was discovered and characterized. The sequence previously characterized of BcssDV1 (from…
Case Study Reveals Novel Intragenic Deletion of the FXN Gene in Friedreich Ataxia
Ariadna Padró-Miquel, PhD In a recently published case report study of a 32-year-old man with typical clinical features of Friedreich ataxia (FA), parental sample testing led to the identification of a novel intragenic deletion. Overall, the report raises awareness about the potentially higher prevalence of intragenic deletions and highlights the…
LncRNA/circRNA-mRNA networks in CARAS | JIR
Introduction Combined allergic rhinitis and asthma syndrome (CARAS), a new terminology introduced by the World Allergy Organization (WAO) in 2004, is an allergic reaction that occurs in the respiratory tract, including upper respiratory tract allergy (allergic rhinitis, AR) and lower respiratory tract allergy (asthma, AS).1,2 The incidence of AS in…
Azenta opens genomics centre in Oxford
Azenta Life Sciences will set up a new European life sciences hub in Oxford, UK, scheduled to open in March 2024. The site will feature a new genomics lab called Genewiz Multiomics and Synthesis Solutions. The site will make use of the experienced team from the former Oxford Genomics Centre (OGC) and aim to provide fast…
What is Chromosome 4?
Chromosome 4 is the fourth largest of the 23 pairs of chromosomes in humans. Chromosome 4 is made up of over 186 million base pairs, the building blocks of DNA which are tightly packed and super coiled to from the DNA helix. Chromosome 4 represents around 6% to 6.5% of…
Genetics of host plants determine what microorganisms they attract, finds study
Miscanthus species are bioenergy crops because they require lower nutrient concentrations to achieve more growth. Credit: L. Brian Stauffer Plants often develop communities with microorganisms in their roots, which influences plant health and development. Although the recruitment of these microbes is dictated by several factors, it is unclear whether the…
Characterization of the Spectrum of Mitochondrial DNA Nucleotide Substitutions in Human Populations in High Altitude Environments
Burtscher, J., Mallet, R.T., Pialoux, V., et al., Adaptive responses to hypoxia and/or hyperoxia in humans, Antioxid. Redox Signal., 2022, vol. 37, pp. 887—912. doi.org/10.1089/ars.2021.0280 Article PubMed Google Scholar Chandel, N.S., McClintock, D.S., Feliciano, C.E., et al., Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a…
FTC, DOJ finalize merger guidelines that could impede healthcare M&A
Listen to the article 4 min This audio is auto-generated. Please let us know if you have feedback. Dive Brief: Federal antitrust agencies on Monday finalized stricter guidelines for mergers and acquisitions that could make it more difficult for healthcare deals to close. The guidelines lay out a framework that…
Blazing the trail to empower agrigenomics research and conservation
Sequencing data for a single human genome, at 30× coverage, takes up to 70 gigabytes of storage. Illumina instruments produced 280 million gigabytes of data in 2021 alone, and by 2025, we’ll need storage capacity for 40 billion gigabytes—and that’s just for human genomes. The Genomics & Bioinformatics Service of…
DNA Analysis In The Government Sector Market Research Report – Forecasting Size, Share, Manufacturers, Growth Trends, And The Impact Of Covid-19 (2023…
(MENAFN– The Express Wire) Global DNA Analysis in the Government Sector Market 2023 segmented by Manufactures (Lockheed Martin, NEC, M2SYS Technology, MorphoTrust, Ultra Electronics Forensic, NetBio, EyeLock, 3M, A-T Solutions, Stanley Black & Decker), which includes TOC, Fact and Figures, regions. “Final Report will add the analysis of the impact…
Characteristics of Amorphophallus konjac as indicated by its genome
Genome assembly and annotation The DNA sequencing data (1119.58 Gb, average 110× coverage) of the A. konjac sample were obtained using the Illumina Hiseq 2500 sequencer. A summary of the sequence data used for the assembly is presented in Table S1. The estimated genome size is 4,512,012,462 bp using 19-mer frequency distribution based…
Newly developed computational tools and large datasets with low bias will lead to robust neoantigen prediction and improved personalized cancer therapies
Newly developed computational tools and large datasets with low bias will lead to robust neoantigen prediction and improved personalized cancer therapies LONDON, Dec. 18, 2023 (GLOBE NEWSWIRE) — Achilles Therapeutics plc (NASDAQ: ACHL), a clinical-stage biopharmaceutical company developing AI-powered precision T cell therapies targeting clonal neoantigens to treat solid tumors,…
correlations of longitudinal antibody measurements.
Antidouble stranded DNA antibody assays in systemic lupus erythematosus: correlations of longitudinal antibody measurements. Publication , Journal Article Ward, MM; Pisetsky, DS; Christenson, VD Published in: J Rheumatol To determine whether different assays of antidouble stranded DNA (anti-dsDNA) antibodies provide comparable information in quantitative antibody assessment over time, longitudinal correlations between…
Frontiers Publishing Partnerships | Construction of recombinant adenovirus-5 vector to prevent replication-competent adenovirus occurrence
Introduction In recent years, recombinant adenoviral vectors have been used in different fields of biomedical sciences such as in vitro and in vivo gene transfer, vaccine development, and gene therapy (Russell, 2000; Mitani and Kubo, 2002). Multiple features of recombinant adenoviral vectors such as high packaging capacity for transgene insertion,…
Green River Killer victim’s remains found in Auburn in 1985 have been identified
Decades of uncertainty ended this week with the identification of “Bones 17” as Lori Anne Razpotnik, a victim of the Green River Killer found in Auburn in 1985 who remained unknown for 40 years. In 1982, Lori Anne was just 15 years old and lived with her family in Lewis…
Where Is the ‘Microbiome Revolution’ Headed Next?
Human microbiome research has progressed in leaps and bounds over the past decades, from pivotal studies begun in the 1970s to the launch of the Human Microbiome Project in 2007. Breakthroughs have laid the groundwork for more recent clinical applications, such as fecal microbiota transplantation (FMT), and advanced techniques to…
Illumina will divest Grail after court backs FTC ruling
Illumina (Nasdaq:ILMN) announced that it plans to divest Grail after a drawn-out legal battle over the $7.1 billion acquisition. In September 2020, Illumina announced an agreement to acquire Grail, a DNA sequencing and array-based tech developer. Grail itself was a startup that initially spun out from the company in 2016….
Biotechnology Breakthroughs: How Genetic Engineering is Revolutionizing Healthcare
Share Tweet Share Share Email Among the various branches of biotechnology, genetic engineering stands out as a revolutionary field that holds immense potential for transforming healthcare as we know it. This article explores the latest biotechnological breakthroughs, focusing on how genetic engineering is…
Big problems, small solutions: how synthetic biology is building a stronger future
Damaris Mills is its president Integrated DNA TechnologiesA global genomics solutions provider. getty Every fall, millions of Americans get their annual flu shots — and while they’re at it, they now also get their annual Covid-19 booster. Already, these shots seem routine; It’s easy to forget that the initial COVID-19…
Owkin and MSD to collaborate on cancer diagnostics
Artificial intelligence (AI) biotech firm Owkin has formed a collaboration with MSD, the tradename of Merck, to develop and commercialize AI-powered digital microsatellite instability high (MSI-H) pathology cancer diagnostics for EU markets. The financial terms of the agreement have not been disclosed. The collaboration seeks to develop a pre-screening procedure…
The Next Chapter in Genome Editing? Tome Emerges from Stealth with $213M
Rahul Kakkar, MD, Tome Biosciences president and CEO While the CRISPR community celebrates the recent first FDA approval of a CRISPR-Cas9 therapy (Casgevy), new entities are making strides in their efforts to write perhaps the definitive new chapter in programmable genome editing. Last week, Tome Biosciences—a developer of genome editing…
Analysis of sepsis combined with pulmonary infection by mNGS
Introduction Sepsis is one of the major diseases that poses a serious threat to human health, and its incidence and in-hospital mortality rates remain high despite the continuous updating of sepsis guidelines.1 Its main clinical manifestations are elevated body temperature, chills, and rapid heart rate, and it is most common…
BetterBase – Microzone
Microzone’s BetterBase was released not too long after ABI released BigDye™ V1.1 & v3.1 for Sanger Sequencing. BetterBase is a novel enhancing buffer specially designed and tested for use with the ABI BigDye™ (Versions 1.1 & 3.1). It is compatible with all Sanger Sequencing systems (eg: the ABI, MegaBACE and…
Viral Vectors and Plasmid DNA Manufacturing market is
Visiongain has published a new report entitled Viral Vectors & Plasmid DNA Manufacturing Market Report 2024-2034: Forecasts by Vector Type (Adenovirus, Retrovirus, Plasmid DNA, AAV, Lentivirus, Others), by Application (Antisense and RNAi, Gene Therapy, Cell Therapy, Vaccinology), by End-use (Pharma and Biopharma Companies, Research Institutes), by Disease (Oncology, Genetic Disorders,…
A super-pangenome of the North American wild grape species | Genome Biology
Alston JM, Sambucci O. Grapes in the world economy. In: Cantu D, Walker MA, editors. The grape genome. Springer International Publishing; 2019. p. 1–24. Google Scholar Rahemi A, Dodson Peterson JC, Lund KT. Grape rootstocks and related species. Cham: Springer International Publishing; 2022. Walker MA, Heinitz C, Riaz S, Uretsky…
Sperm Cell Powerhouses Contain Almost No DNA
January 1, 2024 2 min read Scientists discover why fathers usually don’t pass on their mitochondria’s genome By Sneha Khedkar Credit: Kateryna Kon/Science Source Almost every human cell is powered by mitochondria, bean-shaped organelles that use oxygen to synthesize usable energy. These structures evolved billions of years ago from free-swimming…