Tag: dNdScv
The evolution of non-small cell lung cancer metastases in TRACERx
The TRACERx 421 cohort The TRACERx study (clinicaltrials.gov/ct2/show/NCT01888601) is a prospective observational cohort study that aims to transform our understanding of NSCLC, the design of which has been approved by an independent research ethics committee (13/LO/1546). Informed consent for entry into the TRACERx study was mandatory and obtained from every…
The evolution of lung cancer and impact of subclonal selection in TRACERx
The TRACERx 421 cohort The TRACERx study (clinicaltrials.gov/ct2/show/NCT01888601) is a prospective observational cohort study that aims to transform our understanding of NSCLC, the design of which has been approved by an independent research ethics committee (13/LO/1546). Informed consent for entry into the TRACERx study was mandatory and obtained from every…
driver genes per sample or per group?
driver genes per sample or per group? 0 When using driver genes prediction tools such as ONCOCLUST in maftools or dNdScv, should we input the variants of per samples? or per group (same treatment/disease)? Both tutorials use input that were from multiple subjects. Is driver genes are usually described as…
Phenotypic plasticity and genetic control in colorectal cancer evolution
Sample preparation and sequencing The method of sample collection and processing is described in a companion article (ref. 23). Sequencing and basic bioinformatic processing of DNA-, RNA- and ATAC-seq data are included there as well. Gene expression normalization and filtering The number of non-ribosomal protein-coding genes on the 23 canonical chromosome pairs…
