Tag: EMBL-EBI

PA in Director’s Office EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: Directors OfficeJob Number: EBI02200Contract Type: Staff MemberAdvertised Grade-Grading: Grade 5 – 6 (depending on experience) Monthly salary from £3,090 – £3,456 after tax – other benefits based on family circumstancesContract Duration-Length of Time (years/months): 3 years…

Join our dynamic team as a Personal Assistant, providing top-notch administrative and organisational support within the EMBL-EBI Directors’ Office to the EMBL-EBI Joint Director; the Hinxton-based EMBL Head of Human Resources; and the Hinxton-based EMBL Head of Strategy. If you’re an experienced and proactive Personal Assistant, excited to contribute to…

Senior Programme Manager EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: Directors OfficeJob Number: EBI02202Contract Type: Staff MemberContract Duration-Length of Time (years/months): 3 years (renewable to a maximum of 9 years)Advertised Grade-Grading: Grade 8 – monthly salary from £4,513.65 after tax plus benefitsClosing date: 22 January 2024 About…

Given the number of advancements artificial intelligence (AI) has made this year itself, it’s no surprise that it has been a significant point of discussion throughout 2023. AI now finds its use case in almost every realm, and one of its exciting and useful applications is in healthcare and medicine….

About the program This prestigious program in an international laboratory is a unique opportunity to explore new frontiers in biomedical, biotech, agri-food, marine, and biodiversity research. It illustrates the collaboration of EMBL’s European Bioinformatics Institute (EMBL-EBI) and the French Embassy’s Department for Higher Education, Research and Innovation to promote the…

  Q&A Report from the workshop: QuestonWha is he bes msa ool?clusal 2 and clusal omega are he sameHow would we ener multple sequences? because here is only one inpu boxCould he legend explaining symbiols (*, -,…) be shown in he resul window?Wha is he max number of sequences one…

Summary DescriptionFAM86B1 540px.gif English: Protein structure of human FAM86B1 isoform 1 predicted by AlphaFold. Colored by secondary structure, with alpha helices in red and beta strands in yellow. The SKL2 peroxisomal targeting signal is shown in green. Remaining coils are blue. gif shows FAM86B1 slowly spinning, so that the full…

About the team/job We are looking for a Bioinformatician to join the Open Targets data team. We are seeking an enthusiastic team member to expand our informatics platforms through the integration of single cell omics data to enhance drug discovery. This role would suit someone with experience in data integration…

ELIXIR Senior Project Manager EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: ELIXIR Project Management UnitJob Number: EX00062Contract Type: Staff MemberSchedule Type: Full Time/Part TimeAdvertised Grade-Grading: Grade 6 (monthly salary from £3,456.96 after tax + benefits)Contract Duration-Length of Time (years/months): 3 yearsClosing date: 1 January 2024 About the…

For instance, computational approaches led by the Materials Project and other groups have helped develop 28,000 new materials till date. But this is an expensive and time-consuming process, and researchers may find it difficult to develop radically different structures since they mostly work with existing materials. Recently, though, Google unit…

Open Targets (OT) is a unique public-private partnership working to deliver experimental data and informatics platforms that enable researchers to make more informed decisions about target selection for drug discovery. OT is a shared initiative between the European Bioinformatics Institute (EMBL-EBI), a global leader in the management, integration and analysis…

Support Specialist for Deicpher Project EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: Genome Assembly & AnnotationJob Number: EBI02203Contract Type: Staff MemberContract Duration-Is this renewable to 9 years?: if suficient funds renewedContract Duration-Length of Time (years/months): 2 years (Project based contract until May 2026)Advertised Grade-Grading: Grade 5 monthly…

KAO DATA, the specialist developer and operator of data centres engineered for AI and advanced computing, has formed a new commercial partnership with Jisc, the UK’s digital, data and technology agency focused on tertiary education, research and innovation.  As part of a new data centre referral agreement, Jisc has chosen…

Cell culture All cell lines used in this study were cultured at 37 °C in 5% CO2 in a humidified incubator. Human cell lines were authenticated by STR profiling using Promega GenePrint 10 and tested for Mycoplasma using Mycoalert (Lonza). Other than HCT116 p21−/− (a gift of B. Vogelstein60) all cell…

We created tracks with Alphafold-linked proteins for selected genome browsers allowing for links to predicted 3D structures. Publication: Jumper et al. Nature (2021) – “The AlphaFold Protein Structure Database is available through EMBL-EBI” In those select browsers, you will find the following protein track: The following organisms contain protein tracks…

In late 2023, DeepMind unveiled the latest iteration of its revolutionary protein structure prediction system, AlphaFold. Dubbed “AlphaFold 3”, this new version represents a major leap forward, with the ability to predict structures not just for proteins, but for other crucial biological molecules with unparalleled accuracy. The Origins of AlphaFold…

Gain an introduction to the technology, data analysis, tools, and resources used in RNA sequencing and transcriptomics. The content will provide a broad overview of the subject area, and introduce participants to basic analysis of transcriptomics data using the command line. It will also highlight critical public data repositories and…

Digital Content Editor – EMBL-EBI – European Bioinformatics Institute, Hinxton Digital Content Editor EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom We are looking for a talented Digital Content Editor to join the ELIXIR Hub. In this role you will write and edit text for the main ELIXIR website as…

image:  The Global Biodiversity Data Portal: enabling biodiversity research worldwide   view more  Credit: Karen Arnott/EMBL-EBI EMBL’s European Bioinformatics Institute (EMBL-EBI) has launched the Global Biodiversity Portal – an open access data portal that will consolidate genomic information from different biodiversity projects within the Earth BioGenome Project.  Sequencing and storing…

The new initiative brings together genomic data from various biodiversity projects to aid conservation and biodiversity efforts The Global Biodiversity Data Portal. Credit: Karen Arnott/EMBL-EBI Summary The Global Biodiversity Portal is a centralised open-access database that consolidates genomic information collected from projects that make up the Earth BioGenome Project,…

Abstract The mitochondrial genome, mtDNA, is present in multiple copies in cells and encodes essential subunits of oxidative phosphorylation complexes. mtDNA levels have to change in response to metabolic demands and copy number alterations are implicated in various diseases. The mitochondrial HMG-box proteins Abf2 in yeast and TFAM in mammals…

About the team/job We are looking for an enthusiastic and driven Backend Software Developer to join Open Targets at EMBL-EBI. We are open to applicants at different career stages, but we are keen to find someone who wants to embrace cutting-edge technologies in order to tackle complex challenges in drug…

In recent decades, the development of computational and bioinformatics tools and websites for life sciences has increased exponentially. This great development has gone hand in hand with the availability of genome, proteome and macromolecule structure databases, and also of functional experiments, including microarray and RNAseq expression data, RNA-protein interactions, ChIP-seq,…

Abstract The European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) is one of the world’s leading sources of public biomolecular data. Based at the Wellcome Genome Campus in Hinxton, UK, EMBL-EBI is one of six sites of the European Molecular Biology Laboratory (EMBL), Europe’s only intergovernmental life sciences organisation. This…

Van Valen, L. A new evolutionary law. Evol. Theory 1, 1–30 (1973). Google Scholar  Woolhouse, M. E. J., Webster, J. P., Domingo, E., Charlesworth, B. & Levin, B. R. Biological and biomedical implications of the co-evolution of pathogens and their hosts. Nat. Genet. 32, 569–577 (2002). Article  CAS  PubMed  Google…

Image by Gerd Altmann from Pixabay For downloading data and standardized metadata from GEO (Gene Expression Omnibus) and SRA (Sequence Read Archive), several bioinformatics and command-line tools and scripts are available, primarily hosted on GitHub. ARA: An automated pipeline developed for better sampling of NCBI SRA database records, allowing full…

Description As we navigate a period of transformation, our Operations Team is excited to announce a significant expansion. Currently, we comprise a dynamic group of 9 colleagues, spanning a spectrum of experience from Java developers to Site Reliability Engineers (SREs). Our team, previously known as Software Development & Operations and…

Head of Campus Operations EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: AdministrationJob Number: EBI02194Contract Type: Staff MemberAdvertised Grade-Grading: Grade 10 (monthly salary from £6,915.59 after tax plus benefits)Contract Duration-Is this renewable to 9 years?: YesClosing date: 03 December 2023 About the team/job The European Molecular Biology Laboratory…

The European Molecular Biology Laboratory (EMBL), is a non-profit, Intergovernmental Organisation funded by 27 EMBL member states and 2 associate member states. EMBL has over 2,000 members of personnel from over 80 nations based across its six sites: Heidelberg (Germany), Hinxton near Cambridge (UK), Grenoble (France), Hamburg (Germany), Rome (Italy)…

We are looking for a Software Developer to join the European Variation Archive (EVA – www.ebi.ac.uk/eva/) team. The EVA is a cutting-edge genetic data repository that plays a pivotal role in the field of genomics. The EVA hosts billions of variants across hundreds of species and is expected to grow…

The aim of this guide is to help you prepare in advance to submit your data to the BioImage Archive. In particular, it provides an overview of what data you should submit, as well as the information you’ll need to provide with your images so that you can think about…

About the team/job The European Bioinformatics Institute (EMBL-EBI) is seeking a Software Developer to join the European Variation Archive (EVA – www.ebi.ac.uk/eva/) team. The EVA is a cutting-edge genetic data repository that plays a pivotal role in the field of genomics. The EVA hosts billions of variants across hundreds of…

About the team/job We are searching for a talented individual to work on systems to enable better search and discoverability of life sciences images and their annotations. The role will suit a creative, innovative person who enjoys being part of a high performing team working on critical scientific infrastructure. The…

The work and excellence of EMBL researchers have been recognised with multiple awards and honours during the past six months. Three EMBL predocs, Constantin Ahlmann-Eltze in the Huber Group at EMBL Heidelberg, Charlie Barker in the Petsalaki Group at EMBL-EBI, and Sora Matsumoto in the Saka Group at EMBL Heidelberg…

Global Engagement Manager EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: Directors OfficeJob Number: EBI02195Contract Type: Staff MemberContract Duration-Length of Time (years/months): 2 yearsAdvertised Grade-Grading: Grade 6 (monthly salary from £3,456.96 after tax + benefits)Closing date: 13 December 2023 About the team/job We are seeking a Global Engagement…

Large language models are changing the way we carry out scientific data curation, annotation, and research, setting the stage for a more efficient understanding of scientific literature Credit: Karen Arnott/EMBL-EBI In a world inundated with data, curating valuable information has never been more challenging, or more important. From academic papers…

About the team/job We are seeking a Global Engagement Manager to lead a two-year pilot programme of engagement that will be pivotal in defining our future strategy to deliver the EMBL-EBI data resources in a more globally equitable way.  EMBL is Europe’s flagship laboratory for the life sciences. An intergovernmental…

Abstract ChannelsDB 2.0 is an updated database providing structural information about the position, geometry and physicochemical properties of protein channels—tunnels and pores—within deposited biomacromolecular structures from PDB and AlphaFoldDB databases. The newly deposited information originated from several sources. Firstly, we included data calculated using a popular CAVER tool to complement…

The European Bioinformatics Institute (EMBL-EBI) is part of the European Molecular Biology Laboratory (EMBL) and home to the world’s most comprehensive range of freely available molecular data resources. EMBL-EBI underpins flagship large-scale science programmes such as UK Biobank 500,000 whole genome sequence analysis, the Human Cell Atlas and the Darwin…

About the team/job The Cortes-Ciriano group co-leads the CRUK-funded Stratified Medicine Pediatrics Programme (SMPEDS). SMPEDS is the UK national molecular profiling platform for children with relapsed cancer and it successfully provides infrastructure to triage patients into clinical trials by identifying molecular abnormalities in rapid turnaround, with clinical reporting through a…

About the team/job We are excited to offer a brand new role for an experienced Accountant with a flair for both management and financial accounting within the ELIXIR Administration and Operations team, located in Hinxton, near Cambridge. Within this varied position you will add value, overseeing ELIXIR’s budget and financial…

Candidatul Ideal You have •Degree in computer science or a related field;•minimum two years experience in software development;•good knowledge of Java, at least one Javascript framework like React or Angular, as well as indexing and database technologies like Lucene, SolR, SQL;•knowledge of REST APIs and how to interface with them;•experience…

Research Management Officer EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: Genome Assembly & AnnotationJob Number: EBI02182Contract Type: Staff MemberContract Duration-Length of Time (years/months): 3 years (renewable to a maximum of 9 years)Advertised Grade-Grading: Grade 5 (monthly salary starting at £3090.08 after tax) plus benefitsClosing date: 26 November…

European Molecular Biology Laboratory (EMBL), Germany, Germany invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at European Molecular Biology Laboratory (EMBL), Germany, Germany. Eligible candidate may Apply as soon as possible.   (01) Postdoctoral Fellowship Position Postdoc…

Progress update: Our latest AlphaFold model shows significantly improved accuracy and expands coverage beyond proteins to other biological molecules, including ligands ‍ Since its release in 2020, AlphaFold has revolutionised how proteins and their interactions are understood. Isomorphic Labs and Google DeepMind have been working together to build the foundations…

In collaboration with the AI-powered drug discovery company Isomorphic Labs, Google DeepMind has released a new iteration of the protein structure prediction model, AlphaFold 2. The latest model can predict structures for most molecules in the Protein Data Bank (PDB) with high accuracy, often reaching atomic precision, in various important…

As science increasingly relies on big data and AI tools, the carbon footprint of computational work is on the rise Credit: Karen Arnott/EMBL-EBI Source article(s) GREENER principles for environmentally sustainable computational science Lannelongue, L., et al. Nature Computational Science 26 June 2023 10.1038/s43588-023-00461-y Tags: artificial intelligence, bioinformatics, cloud computing, computational biology,…

EMBL-EBI is an intergovernmental organisation who specialises in managing big data in biology. Growing rapidly over the last decade, EMBL-EBI hosts over 800 members of personnel in two permanent office buildings of different generations and designs, with one temporary office facility and a third permanent office building currently under construction…

Dear all, We are excited to announce two significant functionalities added to the AlphaFold Protein Structure Database (AlphaFold DB). The database has expanded since its inception in 2021 to cover over 214 million predicted structures from Google Deepmind’s AlphaFold 2 system. We now introduce sequence similarity-based search and enhanced prediction…

EMBL researchers have created an engineered uterus that allows a closer look at a mouse embryo’s development and its interactions with the uterine environment The early stages of development of a mouse embryo, in which the embryo reaches its proper shape and internal structure. The extraembryonic ectoderm cells (green) slowly…

We are seeking two talented and enthusiastic IT support engineers to join our growing Service Desk function, providing both remote and on-site support to EMBL-EBI’s 850 users. You’ll be part of a friendly team providing first line support to a diverse user base, with requirements ranging from daily desktop issues…

EMBL stands as a leader, exemplifying how to harmoniously integrate AI in research and through its delivery of data services   Ewan Birney, Deputy Director General of EMBL and Director of EMBL-EBI. Photo credit: Jeff Dowling/EMBL-EBI By Ewan Birney, Deputy Director General of EMBL and Director of EMBL’s European…

The European Bioinformatics Institute (EMBL-EBI) offers a wide range of bioinformatics sequence analysis applications for free through web and programmatic access. This two-day course is designed to provide a comprehensive overview of sequence analysis tools and how to use the workflows effectively, covering hands-on exercises and demonstrations throughout.  The first…

Dear all, We are excited to inform you of some upcoming enhancements to PDBe’s ligand-related API endpoints and are seeking your valuable insights! *We are running this survey (forms.gle/agPUGCn59ffuayp57) *to collect information on two crucial points: – *Current Usage of PDBe’s Ligand-Related API Endpoints*: We want to understand which of…

Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012;13:260–70. Article  CAS  PubMed  PubMed Central  Google Scholar  Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nat Med. 2018;24:392 NIH Public Access. Article …

We are working on aggregating and displaying all the data available for macromolecular complexes in the PDB and would like to learn more about the types of data regarding complexes that you find helpful in your research. PDBe-KB (pdbe-kb.org) is a community-driven data resource at EMBL-EBI that integrates functional annotations…

Storage Engineer EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: Technical ServicesJob Number: EBI02180Contract Type: Staff MemberContract Duration-Length of Time (years/months): 3 years (renewable up to 9 years)Advertised Grade-Grading: Grade 6 (Monthly salary starting at £3,456 after tax) + Other paid benefits and allowances based on circumstancesClosing date:…

We are seeking a Storage professional to join our Storage team within our I.T. team, serving an institute of over 800 researchers and technical staff. You will be working closely with members of the IT Department and more widely with technical users across EMBL-EBI, overseeing the design, deployment, and operation…

This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL-EBI’s service teams, and from each other. These facilities play an essential role in enabling research in the molecular life sciences. The landscape is constantly evolving as new research tools emerge, as experiments become…

AlphaFold database (AlphaFold DB) provides open access to over 200 million protein structure predictions to accelerate scientific research. This webinar aims to provide a comprehensive introduction to AlphaFold DB. Participants will gain a clear understanding of the fundamental concepts, principles, and functionalities of the database. They will learn how to access…

In July 2022, we launched AlphaFold protein construction predictions for almost all catalogued proteins recognized to science. Learn the most recent weblog here. As we speak, I’m extremely proud and excited to announce that DeepMind is making a big contribution to humanity’s understanding of biology. After we announced AlphaFold 2…

AI In Bioinformatics – How To Use AI In Bioinformatics In the exciting world of biology, Fernanda Garcia Fossa, a dedicated PhD student from Brazil, found herself facing a daunting challenge. She was studying nanotoxicology and needed to analyze countless images of human cells. But the process was painstakingly slow…

About the team/job We seek an experienced front-end developer interested in biological data to join the Velankar team at the European Bioinformatics Institute (EMBL-EBI) to work on web services related to the Protein Data Bank in Europe (pdbe.org). This post is an exciting opportunity to work as part of EMBL-EBI…

In a recent review published in Nature, a group of authors reviewed the progress and challenges in annotating the human genome, including protein-coding genes, isoforms, and non-coding ribonucleic acids (RNAs), and advocated for a universal annotation standard for clinical use. Study: The status of the human gene catalogue. Image Credit:…

Understanding our Genetic Inheritance: The US Human Genome Project, The First Five Years 1991-1995 (US Department of Health and Human Services, US Department of Energy, 1990). Nurk, S. et al. The complete sequence of a human genome. Science 376, 44–53 (2022). Describes the first complete gap-free assembly and annotation of…

Artificial-intelligence programs can speed up monotonous tasks in research — and the learning curve is not too steep.Credit: Luis Alvarez/Getty Image-analysis tools can do amazing things. Yet despite their power, Fernanda Garcia Fossa was frustrated. A biology PhD student at the State University of Campinas, Brazil, Garcia Fossa specializes in…

What is abrin? In certain parts of Asia and Australia, grows a flowering plant of the bean family Fabaceae, known as Abrus precatorius, also more commonly as jequirity bean or rosary pea [1]. It’s a delicate, perennial climber but extremely invasive and classified as a weed in several countries. However, what…

Examine fixing protein folding at deepmind.com/AlphaFold and see a timeline of our breakthrough here. It’s been one yr since we launched and open sourced AlphaFoldour AI system to foretell the 3D construction of a protein simply from its 1D amino acid sequence, and created the AlphaFold Protein Structure Database (AlphaFold…

Postdoctoral Fellow – Pathogen Informatics and Modelling Group EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom The Pathogen Informatics and Modelling group at EMBL-EBI aims to develop innovative approaches to help apply the power of sequencing to controlling pathogen threats. We are interested both in producing methods, and generating biological…

Learn about the tools, processes, and analysis approaches used by MGnify in the field of genome-resolved metagenomics. This course will cover the use of publicly available resources to manage, share, analyse, and interpret metagenomics data, focussing primarily on the assembly-based approaches used in MGnify analysis. The delivered content will involve…

The award recognises EMBL’s varied activities in applying AI to life science research EMBL scientists apply and develop AI tools in collaborative life science research in many different areas, from structural biology and image analysis to omics and technology development. The German AI prize is awarded by WELT for outstanding…

Cancer drugs known as checkpoint blockade inhibitors have proven effective for some cancer patients. These drugs work by taking the brakes off the body’s T cell response, stimulating those immune cells to destroy tumors. Some studies have shown that these drugs work better in patients whose tumors have a very…

PhD student Valentia Lorenzi is using single-cell sequencing data to create a map of the developing human reproductive system Valentina Lorenzi, PhD student at EMBL-EBI. Photo credit: Jeff Dowling/EMBL-EBI Human reproductive development represents an area of research that, despite its fundamental importance, has been overlooked in the past due to…

Description About the team/job The group develops computational tools to realise the vision that one day early cancer detection will be a routine activity using minimally-invasive techniques, and to characterise the patterns of mutations and genome instability processes in human cancers. The group uses diverse data analysis techniques and experimental…

Applications close: 29 October 2023 Course dates: 12 – 16 February 2024 Course fee: £225.00 APPLY NOW Gain an introduction to the technology, data analysis, tools, and resources used in RNA sequencing and transcriptomics. The content will provide a broad overview of the subject area, and introduce participants to basic…

David Hulcoop discusses how his experience bridging organisational cultures will help address critical challenges in drug discovery and target selection at Open Targets David Hulcoop, Executive Director of Open Targets. Credit: Jeff Dowling/EMBL-EBI Open Targets is a public-private partnership which aims to use the information generated by genome sequencing and…

About the team/job EMBL-EBI and AstraZeneca are located nearby in Cambridge which will allow fellows to spend time at both sites and take advantage of the complementary expertise and opportunities this offers. Fellows will have easy access to scientific expertise, well-equipped computational facilities and an active seminar programme. Your role…

The 2023 Albert Lasker Basic Medical Research Award has been presented to Demis Hassabis, PhD, and John Jumper, PhD, for the invention of AlphaFold, a revolutionary technology for predicting the 3-dimensional structure of proteins. Protein folding is one of the most important and complex organizing forces within the human cell,…

Together with The Laboratory for Molecular Infection Medicine Sweden (MIMS) and the SciLifeLab & Wallenberg National Program for Data-Driven Life Science (DDLS), Umeå University is looking for two excellent young researchers to become Group Leaders. Fellowships are targeted towards applicants to start their first independent group within a few years of…

About the team/job Recent advances in technology and analysis have revealed significant opportunities to further our understanding of the diversity and impact of human genetics (such as the first full length telomere-to-telomere human genome and the first release of the human pangenome). As a result, we are excited to launch…

New AI tool classifies the effects of 71 million ‘missense’ mutations  Uncovering the root causes of disease is one of the greatest challenges in human genetics. With millions of possible mutations and limited experimental data, it’s largely still a mystery which ones could give rise to disease. This knowledge is…

Caption:In this colon tumor, which has a mutation that gives it a high degree of DNA mismatch repair deficiency, T cells (labeled black, green, and red) have accumulated primarily in the supportive tissues (pink regions), while very few have infiltrated tumor cells (islands surrounded by the supportive tissues). Credit: Courtesy…

ELIXIR Project Manager EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: ELIXIR Project Management UnitJob Number: EX00053Contract Type: Staff MemberSchedule Type: Full TimeContract Duration-Length of Time (years/months): 3 yearsAdvertised Grade-Grading: Grade 5 (monthly salary from £3090.08 after tax, plus benefits) Closing Date: 18 October 2023 About the team/job…

This block has been broken or is missing. You may be missing content or require the original module to be enabled. Checkpoint blockade inhibitors, which are cancer drugs, have proven to be effective for some cancer patients. These drugs work by stimulating the body’s T cell response, causing those immune…

image: Immune cells surrounding a tumour with clonal neoantigens view more  Credit: Karen Arnott/EMBL-EBI A new study has shed light on why immunotherapy does not always work in certain types of cancer. Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of…

The results of a study led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and Massachusetts Institute of Technology (MIT), have shed light on why immune checkpoint blockade (ICB) immunotherapy does not always work in some cancers with a high tumor mutational burden (TMB). The…

Researchers from the European Bioinformatics Institute (EMBL-EBI), ETH Zurich’s Institute of Molecular Systems Biology, and Seoul National University’s School of Biological Sciences have made significant strides in protein research. They harnessed the power of AlphaFold’s vast database of AI-predicted 3D protein structures, shedding light on protein evolution and human immunity…

Register for free to listen to this article Thank you. Listen to this article using the player above. ✖ Want to listen to this article for FREE? Complete the form below to unlock access to ALL audio articles. By developing an efficient way to compare all predicted…

A new study has shed light on why immunotherapy does not always work in certain types of cancer. Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of Technology (MIT), the work focuses on understanding why some tumours fail to respond…

Cancer drugs known as checkpoint blockade inhibitors have proven effective for some cancer patients. These drugs work by taking the brakes off the body’s T cell response, stimulating those immune cells to destroy tumors. Some studies have shown that these drugs work better in patients whose tumors have a very…

A new study has shed light on why immunotherapy does not always work in certain types of cancer. Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of Technology (MIT), the work focuses on understanding why some tumours fail to respond…

About the team/job Due to growth and successful new grant applications, we have an opportunity for a Technical Project Officer, (preferably with experience in European Commission (EC)/Innovative Health Initiative (IHI) projects), to join the dynamic and international team at the ELIXIR Hub in Hinxton, UK. The main purpose of this…

– Advertisement – Researchers have used the AlphaFold database to examine predicted protein buildings and determine similarities throughout other species. This analysis improves our figuring out of protein evolution and gives insights into the foundation of human immunity proteins. The AlphaFold database is a treasured useful resource in protein analysis,…

Postdoctoral Fellow – Cortes-Ciriano Group EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Your role We invite applications for a CRUK-funded Postdoctoral Fellow position in the fields of cancer genomics, early detection and long-read sequencing data analysis. We are looking for a talented, and hypothesis-driven individual with experience in analysing…

How are concepts like “white” used in art, literature, and film, and what do the basic processes that control cell division look like? These are the topics on which some of this year’s honorary doctors will lecture when they appear during the fall semester. Honorary doctorates from Stockholm University 2023:…

Revealing the secrets of protein evolution using the AlphaFold database. Credit: Karen Arnott/EMBL-EBI By developing an efficient way to compare all predicted protein structures in the AlphaFold database, researchers have revealed similarities between proteins across different species. This work aids our understanding of protein evolution and has uncovered new insights…

A protein shape called a Beta-barrel.Credit: Laguna Design/Science Photo Library The protein universe just got a lot brighter. Researchers have mined a database containing the structures of nearly every known protein — more than 200 million entries predicted using Google DeepMind’s revolutionary AlphaFold neural network. The work has uncovered completely…

Researchers use the AlphaFold database and Foldseek Cluster algorithm to analyse millions of predicted protein structures and offer new insights into protein evolution Revealing the secrets of protein evolution using the AlphaFold database. Credit: Karen Arnott/EMBL-EBI using protein structure Tubulin alpha-1A chain from cluster.foldseek.com Summary Using the AlphaFold database and…

ELIXIR Technical Project Assistant EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: ELIXIR Project Management UnitJob Number: EX00054Contract Type: Staff MemberSchedule Type: Full TimeJob Function: Administrative Officer (gr. 4-6)Advertised Grade-Grading: Grade 4 – monthly salary starting at £2.866,71 (tax free) + benefitsContract Duration-Length of Time (years/months): 3 yearsClosing…

The Healthcare Technology Report is pleased to announce The Top 25 Healthcare Technology Leaders of Houston for 2023. Houston stands out as a prominent hub for medical device manufacturing, pharmaceuticals, and health research, boasting a thriving ecosystem encompassing over 1,100 well-established life sciences and biotechnology companies. These visionary-led enterprises are…