Tag: ER-lysosome
Autophagy of the ER: the secretome finds the lysosome
Review doi: 10.1111/febs.16986. Online ahead of print. Affiliations Expand Affiliations 1 Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA. 2 Cellular and Molecular Biology Program, University of Michigan Medical School, Ann Arbor, MI, USA. 3 Division of Metabolism, Endocrinology & Diabetes, Department of…
PDZD8 promotes autophagy at ER-Lysosome contact sites to regulate synaptogenesis
Abstract Building synaptic connections, which are often far from the soma, requires coordinating a host of cellular activities from transcription to protein turnover, placing a high demand on intracellular communication. Membrane contact sites (MCSs) formed between cellular organelles have emerged as key signaling hubs for coordinating an array of cellular…
The activation of cGAS-STING in acute kidney injury
Introduction AKI, which is characterised by necroinflammation due to damage and necrosis of the kidney’s intrinsic cells,1 is a common clinical syndrome, occurring in 10–15% of hospitalized patients, whereas in the ICU this percentage is as high as 50%.2 The development of AKI is involved in the production of reactive…
Solved Q3: Lipid transfer at membrane contact sites: The
Transcribed image text: Q3: Lipid transfer at membrane contact sites: The defining feature of eukaryotic cells is the presence of membrane-bound organelles of diverse kinds, each with specialized functions. ER-lysosome contact sites are conserved from yeast to humans. A tether protein X is predicted to form a tether that connects…
The sterol transporter STARD3 transports sphingosine at ER-lysosome contact sites
Abstract Sphingolipids are important structural components of membranes. Additionally, simple sphingolipids such as sphingosine are highly bioactive and participate in complex subcellular signaling. Sphingolipid deregulation is associated with many severe diseases including diabetes, Parkinson’s and cancer. Here, we focus on how sphingosine, generated from sphingolipid catabolism in late endosomes/lysosomes, is…
Scientists uncover molecular mechanism of RNA-mediated organelle contact sites and regulation mechanism of cholesterol metabolism
As an important carrier of material and energy metabolism, the ordinated modulation of organelle-associated molecules are vital for proper cellular and systemic functions. For example, sterol-regulatory element binding proteins (SREBPs), located on the surface of the endoplasmic reticulum (ER), can rapidly sense changes in intracellular lipid levels, modulate the rate…
Two New Studies Close In on the Genetic Underpinnings of Parkinson’s Disease
Variants of at least 20 different genes have been closely linked to the development of Parkinson’s disease, but scientists are still investigating how exactly they cause the severe and incurable motor disorder that afflicts about 1 million people in the U.S. alone. New research by Yale researchers offers important clues….
