Tag: ER-lysosome

Scientists uncover molecular mechanism of RNA-mediated organelle contact sites and regulation mechanism of cholesterol metabolism

As an important carrier of material and energy metabolism, the ordinated modulation of organelle-associated molecules are vital for proper cellular and systemic functions. For example, sterol-regulatory element binding proteins (SREBPs), located on the surface of the endoplasmic reticulum (ER), can rapidly sense changes in intracellular lipid levels, modulate the rate…

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Two New Studies Close In on the Genetic Underpinnings of Parkinson’s Disease

Variants of at least 20 different genes have been closely linked to the development of Parkinson’s disease, but scientists are still investigating how exactly they cause the severe and incurable motor disorder that afflicts about 1 million people in the U.S. alone. New research by Yale researchers offers important clues….

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