Tag: ERA

Xenotransplantation: Argentina is about to produce genetically modified animals for human transplants

While the international medical community celebrates the first successful xenotransplantation, in Argentina two research teams from public universities are preparing to produce genetically modified animals so that their organs are suitable for human transplants and the first pigs of this type would be obtained at the end of this year…

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Deciphering Protein Structure-Dynamics-Function Relationships in the Post AlphaFold Era

AI techniques have come of age – Google DeepMind’s AlphaFold, and other competitive approaches such as RosettaFold, and the more recent efforts at folding RNA structures using Atomic Rotationally Equivariant Scorer (ARES), have enabled accurate predictions of protein and RNA three-dimensional (3D) structures starting with just their primary sequences….

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Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits

1. Jansen, I. E. et al. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk. Nat. Genet. 51, 404–413 (2019). CAS  PubMed  PubMed Central  Google Scholar  2. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014). PubMed…

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Intern- Bioinformatics – Foster City

Gilead Sciences is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensure the…

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Toll-like receptor 2/4 in Chinese patients with sepsis

Introduction Sepsis is a life-threatening organ dysfunction that results from an exaggerated host immune response to disseminate infection.1 Despite improvements in treatment strategies, sepsis remains a leading cause of death in critically ill patients worldwide.2 Low platelet number, known as thrombocytopenia, is common in infectious diseases (also sometimes referred to…

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Gilead Sciences hiring Intern – Bioinformatics in Foster City, California, United States

Gilead Sciences is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensure the…

Continue Reading Gilead Sciences hiring Intern – Bioinformatics in Foster City, California, United States

Bioinformatics Analyst – Emory Healthcare/Emory University

Discover Your Career at Emory University Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future.We welcome candidates who can contribute to the diversity and excellence of our academic community. Description JOB DESCRIPTION: + Maintains software, hardware…

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Real-World Assessment of Patient Care and Practice Efficiency With the Introduction of Subcutaneous Rituximab

Introduction Rituximab (Rituxan; Genentech) is a chimeric anti-CD20 monoclonal antibody widely used in non-Hodgkin lymphoma (NHL) treatment.1 Worldwide, rituximab is recommended for a variety of B-cell malignancies,1,2 and it has a well-established efficacy and safety profile, with more than 4 million patients treated.1,3 In the United States, rituximab is approved…

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The Future of Targeted Therapies in DLBCL

In an interview with Targeted Oncology, Thomas Habermann, MD discusses the current unmet needs in the DLBCL space, along with the future of targeted therapies. While rituximab (Rituxan), cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is a highly effective therapy for diffuse large B-cell lymphoma (DLBCL). However, major unmet clinical needs still exist for patients with…

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Genome-wide identification of enhancers and transcription factors regulating the myogenic differentiation of bovine satellite cells | BMC Genomics

1. Yin H, Price F, Rudnicki MA. Satellite cells and the muscle stem cell niche. Physiol Rev. 2013;93(1):23–67. CAS  PubMed  PubMed Central  Google Scholar  2. Hoppeler H, Fluck M. Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sport Exer. 2003;35(1):95–104. CAS  Google Scholar  3. Astruc T: Carcass Composition,…

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Unlocking the Cotton Genome: Space-bound Research ‘Large Step’

Clemson researcher Chris Saski admits sending the University’s iconic Tiger Paw to space aboard a SpaceX Dragon spacecraft is, quite literally, “an out-of-this-world experience.”  But it’s the potential for the experiments in the flight hardware to which the Paw is attached that truly excites him. Saski’s cotton regeneration research, adorned…

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Establishment of sunitinib-resistant CDX model of ccRCC

Introduction Renal cell carcinoma (RCC) accounts for approximately 2–3% of all malignant tumors, and its prevalence is rising. Metastatic RCC accounts for 25–30% of all RCC cases, and has an exceedingly poor prognosis.1 In 2020, among approximately 430,000 newly discovered cases of RCC, 179,000 died.2 Clear cell renal cell carcinoma…

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Towards the biogeography of prokaryotic genes

1. Sunagawa, S. et al. Structure and function of the global ocean microbiome. Science 348, 1261359 (2015). PubMed  Google Scholar  2. Zou, Y. et al. 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses. Nat. Biotechnol. 37, 179–185 (2019). CAS  PubMed  PubMed Central  Google Scholar  3. Mohammad,…

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Role of GPs in changing landscape of fertility treatment

PRIMARY care has for years been the cornerstone of the Australian health care system and GPs represent an integral part of it. As they are frequently responsible for the first, and sometimes only, contact of individuals with the health care system, they can profoundly affect a patient’s experience, expectations and…

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From Measuring Rods To Dna Sequencing

Specifications Sub-Genre: Disease & Health Issues Publisher: Palgrave MacMillan Author: Ingrid Voléry & Marie-Pierre Julien Street Date: December 20, 2021 TCIN: 85457678 UPC: 9789811575846 Item Number (DPCI): 247-15-3396 Origin: Made in the USA or Imported Description Book Synopsis Chapter 1: Introduction: What measuring means.- Part I. The Measurements of the…

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Metagenomics for epidemiological surveillance in ONE HEALTH

Next-Generation Sequencing (NGS) technology has led to a new era of studying microorganisms. Using this tool, our knowledge and understanding of microbiology has expanded at a rapid pace compared to traditional methods that rely on cell culture, microscopy, serology, and polymerase chain reaction (PCR). At the community level, microorganisms…

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Senior Bioinformatics Scientist II/ Staff Bioinformatics Scientist

Inscripta was founded in 2015 and recently launched the world’s first benchtop Digital Genome Engineering platform. The company is growing aggressively, investing in its leadership, team, and technology with a recent $150mm financing round led by Fidelity and TRowe price. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents,…

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The $11-billion Webb telescope aims to probe the early Universe

Lisa Dang wasn’t even born when astronomers started planning the most ambitious and complex space observatory ever built. Now, three decades later, NASA’s James Webb Space Telescope (JWST) is finally about to launch, and Dang has scored some of its first observing time — in a research area that didn’t…

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Identification of lipid metabolism-associated gene signature

Background Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer. Despite the dramatic improvement in breast cancer prognosis due to recent therapeutic advances, such as more effective adjuvant and neo-adjuvant chemotherapies, together with more radical and safer surgery, advances in early diagnosis and treatment over the…

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Sr. Research Scientist I, Bioinformatics job with Gilead Sciences, Inc.

Sr. Research Scientist I, BioinformaticsUnited States – California – Foster City Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with…

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Job vacancy in Global Worldwide: Part-Time Bioinformatics Analyst, Vision Research at Emory University

Job details Job type full-time Full job description Discover your career at emory university: emory university is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the futureWe welcome candidates who can contribute to the diversity and excellence of our academic…

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Scientists Say They Could Bring Back Woolly Mammoths. But Maybe They Shouldn’t | THE DAILY TRIBUNE

Agencies | Washington The Daily Tribune – www.newsofbahrain.com Using recovered DNA to “genetically resurrect” an extinct species — the central idea behind the Jurassic Park films — may be moving closer to reality with the creation this week of a new company that aims to bring back woolly mammoths thousands of years…

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Principle Investigators in lifeomics, bioinformatics, data science and AI in biomedicine

The National Center for Protein Sciences (Beijing) (NCPSB), also known as the PHOENIX Center(Pilot Hub Of ENcyclopedic proteomIX) is a leading science and technology infrastructure for biomedical research in China. Approved and jointly built by the State and Beijing local governments, the Phoenix Center currently harbors the world’s largest cutting-edge…

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Transcriptome assembly, annotation and submission to GenBank for unannotated organisms

Monday, October 4 at 3:00pm to 4:00pm Virtual Event Transcriptome assembly and annotation is a complex process that requires the integration of multiple databases using several computational tools for best results. The advances in next-generation sequencing technologies and the decrease in the cost of sequencing a complete transcriptome are driving…

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A Day in the Life of a Genetic Counselor in the Yale Genetics Department

Genetic counselors bridge the gap between the technical, scientific information of a genetic disease diagnosis or test result and the patient’s understanding of how their genetic information affects their health. With the widespread use of DNA sequencing in cancer and increasingly more conditions in the age of precision medicine, genetic…

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17 Experts Share Technologies Making A Positive Impact On Society

getty In the realm of science fiction, there are plenty of stories focused on technology that ends up having a sinister effect on humankind. And as technology continues to play a greater role in our work and personal lives, cautionary tales have arisen that remind us that even tools created…

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Submit sequence data to NCBI

Data provision and standards. GEO sequence submission procedures are designed to encourage provision of MINSEQE elements: Thorough descriptions of the biological samples under investigation, and procedures to which they were subjected. Thorough descriptions of the protocols used to generate and process the data. Request updates to accessioned records per the…

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De-extinction Could Reverse Species Loss. But Should We Do It?

THE MOST BELOVED BIRD IN HISTORY may very well have been a 29-year-old pigeon by the name of Martha. It was the early 1900s, shortly before the United States entered the First World War, and Martha was at the height of her fame. Perched on her humble roost at the Cincinnati…

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The Problem With the Idea To Bring Back Woolly Mammoths

An illustrated recreation of a woolly mammoth, on display at the Royal Victoria Museum, British Columbia. Credit: Thomas Quine/Flickr, CC BY 2.0 Like Sergey Zimov’s ‘Pleistocene Park’, George Church’s company Colossal plans to repopulate the Arctic tundra with woolly mammoths. Church, a genetic engineering expert, plans to splice mammoth genes…

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Exploiting genomic surveillance to map the spatio-temporal dispersal of SARS-CoV-2 spike mutations in Belgium across 2020

1. Dudas, G. et al. Virus genomes reveal factors that spread and sustained the Ebola epidemic. Nature 544, 309–315 (2017). ADS  CAS  Article  Google Scholar  2. Kafetzopoulou, L. E. et al. Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak. Science 363, 74–77 (2019). ADS  CAS  Article …

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San Diego scientists race to treat rare genetic diseases

Connor Dalby is in many ways your typical 12-year-old boy. He loves dipping his feet in the cool of the ocean and cruising on his bike through his Oceanside neighborhood. He’s mischievous, and he’s got a way of sticking out his chin and grinning madly when goofing off, blue eyes…

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Principal Bioinformatics Scientist Job Opening in San Diego, CA at DermTech

About DermTech: At DermTech, we believe there’s a better way to treat your skin, and we’re using technology, innovation, and data to fundamentally change the way the world practices dermatology. We have developed technology that assesses your skin at the RNA and DNA level, so we can see signs of…

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Job Application for Bioinformatics Analyst at Invitae

U.S. Equal Opportunity Employment Information (Completion is voluntary) Individuals seeking employment at Invitae are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information…

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FTC to take on Trump’s vertical merger guidelines

With help from John Hendel and Leah Nylen — Agency agenda: The FTC plans to rescind Trump-era vertical merger guidelines at today’s open meeting. But how much will that really change? — Broadband moves: As House committees wrap up their portions of Democrats’ social spending package , some lawmakers are…

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Alphafold News – DeepMind and EMBL release the most complete database of,

Jul 22, 2021Jul 22, 2021Jul 22, 2021Dec 03, 2018 · “The AlphaFold database is a perfect example of the virtuous circle of open science,” said EMBL Director General Edith Heard. “AlphaFold was trained using data from public resources built by the …Jul 15, 2021 · reply. pjfin123 32 minutes ago [–]…

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Scientists say they could bring back woolly mammoths, but maybe they shouldn’t

Artist’s impression of a woolly mammoth in a snow-covered environment. Leonello Calvetti/Stocktrek Imag / Getty Images/Stocktrek Images Using recovered DNA to “genetically resurrect” an extinct species — the central idea behind the Jurassic Park films — may be moving closer to reality with the creation this week of a new…

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The future of ‘next generation’ DNA sequencing | Business

Next Generation Sequencing has been with us for little more than a decade, but has already revolutionised biological science. According to Jonas Korlach, chief scientific officer of US-based sequencing company Pacific Biosciences (PacBio) we are now entering a golden age of sequencing technology and the advanced understanding of genetics it…

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Part-Time Bioinformatics Analyst, Vision Research Job Opening in Atlanta, GA at Emory University

Discover Your Career at Emory University: Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future. We welcome candidates who can contribute to the diversity and excellence of our academic community. Description: The Part-Time Bioinformatics Analyst maintains…

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highly accurate prediction with AlphaFold

Posted on 10 September, 202110 September, 2021 This month our attention is turned into structural biology and the revolution on protein structure prediction. How machine learning can boost structural biology understanding? Twenty years after the human genome sequencing, AlphaFold revolutionizes the “3D fields” with the release of 350 000 models for almost all human…

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Old not current gamemode named ‘Murder’ to add to Gmod iceberg. With xFire gone the remaining footage/media seems missing : gmod

It was a game where you had a less colorful UI than the current and no random generated names. You’d be around much more Clue like environments such as a dark storming island with a spooky huge mansion on it. People would all have guns I believe maybe no body…

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Sequenced quoll genome a new tool for conservation

European colonists mistakenly labelled quolls as “native cats” when in fact they are among Australia’s last living carnivorous marsupials. Often overshadowed by their better-known cousins the Tasmanian Devils and the extinct Tasmanian Tiger (thylacine), quolls have a 15 million year history in Australia, successfully balancing shifting ecosystems by suppressing prey…

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Flashpoint US statue of Confederate general removed in Richmond

A towering statue of a Confederate general that became a focal point of protests for racial justice was removed Wednesday in Richmond, the Virginia city that served as the capital of the pro-slavery South during the American Civil War. The bronze statue of General Robert E. Lee, who commanded the…

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A look back at the never-ending nature of epidemics

The more we learn about pathogens, the clearer it becomes that we’ll never escape them Historical writing is always rooted in present-day life, always an answer to what the past can illuminate about our current discontents. Years before “phrases like ‘herd immunity’ and ‘emerging variant’ became household terms,” says Kyle…

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How To Uncompress The 1000 Genome Vcf.Gz File

How To Uncompress The 1000 Genome Vcf.Gz File 2 Hello, Can somebody tell me how to uncompress 1000 Genome vcf.gz files? I am performing an RNA-editing analysis and would like to substract annotated SNPs/INDELs. I have already done so using dbSNP data with bedtools instersect, but am still stuck with…

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nanopore sequencing stock

It holds a 15% stake in the company and has valued its holding at £340m, giving a valuation of more than £2bn for the company. . While the company’s current shareholders have recorded its value at just over £2bn, analysts . Essay from the year 2011 in the subject Business…

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Job Application for Senior/Staff Bioinformatics Scientist at Quantum-Si

U.S. Equal Opportunity Employment Information (Completion is voluntary) Individuals seeking employment at Quantum-Si are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information…

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Indian Wolf Among World’s Most Endangered and Distinct Wolves

The Indian wolf could be far more endangered than previously recognized, according to a study from the University of California, Davis, and the scientists who sequenced the Indian wolf’s genome for the first time.  The findings, published in the journal Molecular Ecology, reveal the Indian wolf to be one of…

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Job Application for Bioinformatics Scientist, Vector Engineering at Voyager Therapeutics

U.S. Equal Opportunity Employment Information (Completion is voluntary) Individuals seeking employment at Voyager Therapeutics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following…

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Gene mutation analysis in papillary thyroid carcinoma

Introduction Thyroid tumors are the most common malignant tumors of the endocrine system, and their incidence has been increasing in the recent decades. Currently, there are some target drugs that can effectively treat PTC, and next-generation sequencing (NGS) can be used for targeted therapy. In order to make better informed…

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ISS CRISPR experiment showed how DNA heals itself in space

If in space, no one can hear you scream, then what happens when DNA silently breaks in microgravity? Spoiler alert: it heals itself. This is what a CRISPR experiment that won the Genes in Space 6 contest — SYFY WIRE was at the recent launch of the Genes in Space 8…

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Honeycomb Biotechnologies hiring Bioinformatics Scientist, Single-Cell Genomics in Waltham, Massachusetts, United States

Company Description:  Honeycomb Biotechnologies is an early-stage company focused on making scalable solutions for storage and single cell genomic analysis of precious clinical samples. We enable translation of the rich biological information encoded in clinical specimens into high-resolution digital information, which can be queried and analyzed with sequencing. The resulting…

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Senior Bioinformatics Software Engineer – jobRxiv

Inscripta was founded in 2015 and recently launched the world’s first benchtop Digital Genome Engineering platform. The company is growing aggressively, investing in its leadership, team, and technology with a recent $150mm financing round led by Fidelity and TRowe price. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and…

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Bioinformatics Software Engineer – jobRxiv

Inscripta was founded in 2015 and recently launched the world’s first benchtop Digital Genome Engineering platform. The company is growing aggressively, investing in its leadership, team, and technology with a recent $150mm financing round led by Fidelity and TRowe price. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents, and…

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Bear study shows environmental impact of antibiotic use

Using DNA harvested from a museum collection of bear fossils, scientists have established a chronology of how widespread antibiotic use in humans and animals has contaminated the environment over time in Sweden. In a study published this week in Current Biology, researchers from Sweden’s Uppsala University conducted whole-genome sequencing on…

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Job Application for Bioinformatics Pipeline Engineer at Invitae

U.S. Equal Opportunity Employment Information (Completion is voluntary) Individuals seeking employment at Invitae are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information…

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Protein-structure prediction revolutionized

Most proteins self-assemble into specific 3D structures that, together with other biological molecules, determine the function and behaviour of cells. Over the past five decades, biologists have experimentally determined the structures of more than 180,000 proteins and deposited them in the Protein Data Bank1, a freely available online resource. Despite…

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Postdoctoral researcher Microbiome Bioinformatics 100%, Zurich, fixed-term

Postdoctoral researcher Microbiome Bioinformatics 100%, Zurich, fixed-term 100%, Zurich, fixed-term The Food Systems Biotechnology (FSB) group is seeking a postdoctoral researcher with expertise in microbiome metagenomics and bioinformatics to lead efforts for characterization and analysis of global microbial biodiversity as part of the Microbiota Vault initiative’s efforts to preserve our microbial…

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Senior Research Scientist, BioInformatics job with Gilead Sciences, Inc.

Senior Research Scientist, BioInformaticsUnited States – California – Foster City Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening…

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Senior Bioinformatics Analyst job in Atlanta, GA | Emory University

Discover Your Career at Emory University Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future. We welcome candidates who can contribute to the diversity and excellence of our academic community. Description JOB DESCRIPTION: Maintains software, hardware…

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Emory University hiring Bioinformatics Analyst in Atlanta, Georgia, United States

Discover Your Career at Emory University Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future . We welcome candidates who can contribute to the diversity and excellence of our academic community. Job Description Description Maintains software,…

Continue Reading Emory University hiring Bioinformatics Analyst in Atlanta, Georgia, United States

Controlling CRISPR | Optics & Photonics News

Light-based approaches for steering CRISPR–Cas9, the powerful Nobel Prize–winning genome-editing toolkit, promise to boost the technique’s precision and specificity—and might help bring it into clinical use. [Getty Images] In early 2011, two scientists walked the cobblestone streets of Old San Juan, the historic district of Puerto Rico’s capital. Recently introduced…

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Postdoctoral researcher: Microbiome Bioinformatics

In der aktuellen Covid-19 Situation laufen die Rekrutierungen weiter. Es kann dabei allerdings zu Verzögerungen kommen. Vielen Dank für Ihr Verständnis. 100%, Zurich, fixed-term The Food Systems Biotechnology (FSB) group is seeking a postdoctoral researcher with expertise in microbiome metagenomics and bioinformatics to lead efforts for characterization and analysis of global…

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Sr Research Associate II, Biologics Analytical Operations job with Gilead Sciences, Inc.

Sr Research Associate II, Biologics Analytical OperationsUnited States – California – Oceanside Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living…

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View All Jobs/Careers – Emory Healthcare/Emory University Psychiatry and Behavioral Sciences

Discover Your Career at Emory University Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future.We welcome candidates who can contribute to the diversity and excellence of our academic community. Description JOB DESCRIPTION: Maintains software, hardware and…

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Another Milestone for CRISPR-Cas9 Technology: First Trial Data for Treatment Delivered Intravenously

Unlike most other CRISPR/Cas-9 therapies that are ex vivo treatments in which cells are modified outside the body, this study was successful with an in vivo treatment Use of CRISPR-Cas9 gene editing technology for therapeutic purposes can be a boon for clinical laboratories. Not only is this application a step…

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AI’s human protein database a ‘great leap’ for research

by Patrick Galey Paris – Scientists recently unveiled the most exhaustive database yet of the proteins that form the building blocks of life, in a breakthrough observers said would “fundamentally change biological research”. Every cell in every living organism is triggered to perform its function by proteins that deliver constant…

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