Tag: ERA

Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil | Malaria Journal

WHO. World Malaria Report. Geneva: World Health Organization; 2019. Google Scholar  Rogerson SJ, Hviid L, Duffy PE, Leke RF, Taylor DW. Malaria in pregnancy: pathogenesis and immunity. Lancet Infect Dis. 2007;7:105–17. Article  CAS  PubMed  Google Scholar  Salanti A, Dahlback M, Turner L, Nielsen MA, Barfod L, Magistrado P, et al….

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What Is Stem Cell Research?

There are cells within our bodies that have a spectacular power. Known as stem cells, they build our bodies before we’re born and regenerate our tissues to keep us alive. For example, stem cells in the skin help us heal from cuts and other stem cells deep in the bone…

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Editas Hits Pause on LCA10 Program in Search of Partner

Editas CMO Baisong Mei and CEO Gilmore O’Neill/courtesy of Editas Medicine   Editas Medicine is pausing its ocular gene therapy program after demonstrating a favorable safety profile and seeking a potential partner to develop EDIT-101, the company announced Thursday.  EDIT-101 is in development for a rare genetic eye disorder, Leber congenital amaurosis 10 (LCA10),…

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3D protein structure predictions made by AI could boost cancer research and drug discovery

The space of characteristic structural elements in AF2 structural models for 21 species. Visualization of t-SNE dimensionality reduction analysis, in which structures with similar structural elements are placed closer together and the 20 most common superfamilies are colored. The axes corresponding to the t-SNE dimension 1 and t-SNE dimension 2…

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Job Application for Senior Bioinformatics Scientist at Invitae

Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a…

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Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D

Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579(7798), 270–273. doi.org/10.1038/s41586-020-2012-7 (2020). Article  ADS  CAS  PubMed  PubMed Central  Google Scholar  Lipsitch, M., Swerdlow, D. L. & Finelli, L. Defining the epidemiology of Covid-19—Studies needed. N. Engl. J. Med. 382(13), 1194–1196. doi.org/10.1056/NEJMp2002125…

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Lessons From ZUMA-7, BELINDA, and TRANSFORM

Dr. Brad Kahl Key Points: Historically, patients with diffuse large B-cell lymphoma (DLBCL) for whom frontline and salvage chemotherapy had failed had little chance of cure; now, 3 chimeric antigen receptor (CAR) T-cell therapies—axicabtagene ciloleucel, tisagenlecleucel, and lisocabtagene maraleucel—show promising prolonged disease-free survival. The ZUMA-7, BELINDA, and TRANSFORM trials compared…

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Postdoctoral Fellow in AI / Bioinformatics, Genetics and Sys Bio

Job Description Job Details: General Notes Prof. S. Stephen Yi’s lab at the University of Texas at Austin invites applications for a postdoctoral fellowship in Bioinformatics, Genetics and Systems Biology starting immediately. We have a longstanding interest in the fundamental question on genotype-phenotype relationships. Prof. Yi is Director of Bioinformatics…

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Report Exposes Rot In Middle East Studies Centers, Connection to CRT

Neetu Arnold, Senior Research Associate of the National Association of Scholars (NAS) has done what amounts to an expose of the politicization of campus Middle East studies centers. What began as – let’s say, a coincidence of timing between generous Arab donations to university study centers offering a pro-Arab, anti-Israel…

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Job Application for Bioinformatics Engineer at Form Bio

Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a…

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Identification of unique DNA methylation sites in Kabuki syndrome using whole genome bisulfite sequencing and targeted hybridization capture followed by enzymatic methylation sequencing

Niikawa N, Matsuura N, Fukushima Y, Ohsawa T, Kajii T. Kabuki make-up syndrome: a syndrome of mentalretardation, unusual facies, large and protruding ears, and postnatal growth deficiency. J Pediatrics. 1981;99:565–9. CAS  Article  Google Scholar  Kuroki Y, Suzuki Y, Chyo H, Hata A, Matsui I. A new malformation syndrome of long…

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Early Trading Has Applied Dna (APDN) Climbing for September 6

Last Price $ Last Trade Change $ Change Percent % Open $ Prev Close $ High $ low $ 52 Week High $ 52 Week Low $ Market Cap PE Ratio Volume Exchange APDN – Market Data & News Trade Applied Dna Sciences Inc (NASDAQ:APDN) is active in pre-market…

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Bioinformatics Analysis of the Key Genes and Pathways in Multiple Myel

Introduction Multiple myeloma is a B-cell malignancy characterized by the malignant proliferation of clonal plasma cells in bone marrow,1 It is the second most common hematological malignancy after lymphoma.2 The age-standardised rate (ASR) of multiple myeloma incidence was 1·78 (95% UI 1·69-1·87) per 100 000 people globally and mortality was…

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NFT of mRNA vaccine research to go on sale

LONDON: A new NFT digital asset from the University of Pennsylvania showcases pivotal mRNA research that could lead to life-changing vaccines for COVID-19 and beyond. Dr. Drew Weissman, a physician and immunologist known for his groundbreaking contributions to RNA biology, and the RNA biochemist Dr. Katalin Kariko developed the modified…

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CLINICAL CHARACTERISTICS AND PROGNOSTIC FACTORS IN PRIMARY BREAST DIFFUSE LARGE B-CELL LYMPHOMA

Keywords Diffuse large B-cell lymphoma, Breast, Prognostic factors, Relapse, Central nervous system References [1] C. Wiseman, and K.T. Liao, Primary lymphoma of the breast. Cancer 29 (1972) 1705-12.www.ncbi.nlm.nih.gov/pubmed/4555557 [2] P.J. Hosein, J.C. Maragulia, M.P. Salzberg, O.W. Press, T.M. Habermann, J.M. Vose, M. Bast, R.H. Advani, R. Tibshirani, A.M. Evens, N….

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Unveiling new perspective of phylogeography, genetic diversity, and population dynamics of Southeast Asian and Pacific chickens

Food and Agriculture Organization. The state of the world’s animal genetic resources for food and agriculture (Rome, 2007). Lawler, A. Dawn of the chicken revealed in Southeast Asia. Science 368, 1411 (2020). ADS  CAS  PubMed  Article  Google Scholar  Sykes, N. A social perspective on the introduction of exotic animals: the…

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AlphaFold reveals the structure of the protein universe

Just one year after its breakthrough release of predicted structures for some 350,000 proteins, DeepMind has unveiled the likely structures of nearly all known proteins — more than 200 million from bacteria to humans — paving the way for the development of new medicines or technologies to tackle global challenges…

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Injectable Drugs Market Analysis of the Competitive Landscape, with a Forecast for 2027

Wilmington, Delaware, United States, Transparency Market Research Inc. – The global injectable drugs market is relied upon to enlist a strong double-digit CAGR within the forecast period from 2019 to 2027. The market is majorly classified on the basis of drug-class, geography, molecule-type, and application. From the previous one entire…

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Acute phase of ischemia-reperfusion in rats

Introduction Stroke is one of the leading causes of death and disability worldwide, which causes substantial economic and social burdens.1 Ischemic stroke is caused by insufficient blood and oxygen supply to the brain,2 accounting for about 85% of the casualties of stroke patients.3 The concept of treatment for ischemic injury…

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Illumina Bioinformatics Jobs For BSc, MSc & PhD

Illumina Bioinformatics Jobs For BSc, MSc & PhD – Apply On-line Illumina Bioinformatics Jobs For BSc, MSc & PhD – Apply On-line. Bioinformatics specialist job openings at Illumina. and eligible candidates can take a look at the entire particulars on the identical under Job Identify – Sr. Bioinformatics Specialist, India…

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Bioinformatics Analyst I/II in Seattle, WA for Fred Hutchinson Cancer Research Center

Details Posted: 13-Aug-22 Location: Seattle, Washington Type: Full-time Salary: Open Overview Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in…

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Multidrug resistance microbial therapy | VMRR

Introduction Antimicrobials are the most important and useful therapeutic discovery in the history of medicine. It allows living beings to survive the microbial disease, enhances invasive surgical procedures, ensures animal health, and protects the food chain since 1928 after the discovery of penicillin. However, the indiscriminate use of antibiotics and…

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Setting up Aspera Connect (ascp) on Linux and macOS

This tiny tutorial cover setting up Aspera Connect (binary is called ascp) which might be used to download sequencing data, e.g. with download links provided by sra-explorer.info, see also sra-explorer : find SRA and FastQ download URLs in a couple of clicks Setting up Aspera Connect is simple and was…

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Cancer vaccines for next generation are available for personal use

Through biomarkers and, increasingly, gene sequencing, we have seen significant advances in disease diagnosis. These advances have enhanced our ability to characterize diseases at the molecular level, and they allow us to uncover ever more subtle distinctions between cancerous cells and normal cells. This addition has prompted significant improvements in…

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DeepMind has predicted the shape of every protein known to science. How excited should we be?

It doesn’t have much photogenic appeal or the glamour of seeing back in time, but a new development in computational biochemistry has been hailed as a discovery as important as the images of distant galaxies recently seen through the James Webb Space Telescope. Researchers at DeepMind—the AI company owned by…

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How common is lymphoma associated with implants?-breakinglatest.news-Breaking Latest News

Let’s go back to talking about the anaplastic large cell lymphoma associated with breast implants. Jama Oncology in fact, it has recently published a letter which estimates its impact in the United States. The new data comes from a study conducted by researchers from Columbia University in New York and…

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This Vast Database Could Upend Science Research

The database includes information that could be incredibly useful to scientists trying to solve some of humanity’s most pressing problems. Seventeen of the database’s proteins relate to “neglected tropical diseases,” which affect the lives of over a billion people worldwide. The Drugs for Neglected Diseases Initiative (DNDI) predicts that the database…

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DeepMind just uncovered the 3D structure of almost every protein known to science

Researchers have deciphered the three-dimensional structures of almost every protein known to science, which could lead to major advances in a wide range of research areas including the treatment of diseases, sustainability and food insecurity. The findings were announced on Thursday by artificial intelligence (AI) technology company DeepMind, which said…

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Careers in genomics – The Hindu

As scientists and other professionals use discoveries in genetics to revolutionise the world, careers in genetics and genomics are booming, given the advances in the field of personalised medicine, DNA sequencing technologies and commercial applications of genetics research. ‘Genomics’ stands for the study of whole genomes. While ‘genes’ are instructions…

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AI predicts shape of nearly every known protein

The structure of the vitellogenin protein — a precursor of egg yolk — as predicted by the AlphaFold tool.Credit: DeepMind From today, determining the 3D shape of almost any protein known to science will be as simple as typing in a Google search. Researchers have used AlphaFold — the revolutionary…

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ASCT is no longer suitable for the majority of patients with DLBCL

Most patients with diffuse large B-cell lymphoma (DLBCL) do not experience significant benefit from treatment with autologous stem cell transplantation (ASCT) and better treatment options are currently available for this population, according to a presentation at the Pan Pacific Lymphoma Conference 2022.1 “ASCT is lousy therapy in the modern age,”…

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Development of a novel core genome MLST scheme for tracing multidrug resistant Staphylococcus capitis

Cui, B., Smooker, P. M., Rouch, D. A., Daley, A. J. & Deighton, M. A. Differences between two clinical Staphylococcus capitis subspecies as revealed by biofilm, antibiotic resistance, and pulsed-field gel electrophoresis profiling. J. Clin. Microbiol. 51, 9–14 (2013). CAS  PubMed  PubMed Central  Article  Google Scholar  Tevell, S., Hellmark, B.,…

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The combined effects of Map3k1 mutation and dioxin on differentiation of keratinocytes derived from mouse embryonic stem cells

Byrne, C., Tainsky, M. & Fuchs, E. Programming gene expression in developing epidermis. Development 120, 2369–2383 (1994). CAS  PubMed  Article  Google Scholar  Pispa, J. & Thesleff, I. Mechanisms of ectodermal organogenesis. Dev. Biol. 262, 195–205 (2003). CAS  PubMed  Article  Google Scholar  Eckert, R. L., Crish, J. F. & Robinson, N….

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The evolutionary origin of host association in the Rickettsiales

Salje, J. Cells within cells: Rickettsiales and the obligate intracellular bacterial lifestyle. Nat. Rev. Microbiol. 19, 375–390 (2021). CAS  PubMed  Article  Google Scholar  Wang, S. & Luo, H. Dating Alphaproteobacteria evolution with eukaryotic fossils. Nat. Commun. 12, 3324 (2021). CAS  PubMed  PubMed Central  Article  Google Scholar  Strassert, J. F. H.,…

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Genetic characterization of two G8P[8] rotavirus strains isolated in Guangzhou, China, in 2020/21: evidence of genome reassortment | BMC Infectious Diseases

Mokomane M, Kasvosve I, Melo Ed, Pernica JM, Goldfarb DM. The global problem of childhood diarrhoeal diseases: emerging strategies in prevention and management. Ther Adv Infect Dis. 2018;5(1):29–43. PubMed  Google Scholar  Organization WH. Rotavirus vaccines: WHO position paper–July 2021. Weekly Epidemiol Rec. 2021;96(28):301–219. Google Scholar  Bucardo F, Reyes Y, Svensson…

Continue Reading Genetic characterization of two G8P[8] rotavirus strains isolated in Guangzhou, China, in 2020/21: evidence of genome reassortment | BMC Infectious Diseases

A closed Candidatus Odinarchaeum chromosome exposes Asgard archaeal viruses

Zaremba-Niedzwiedzka, K. et al. Asgard archaea illuminate the origin of eukaryotic cellular complexity. Nature 541, 353–358 (2017). CAS  PubMed  Article  Google Scholar  Williams, T. A., Cox, C. J., Foster, P. G., Szöllősi, G. J. & Embley, T. M. Phylogenomics provides robust support for a two-domains tree of life. Nat. Ecol….

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Research Faculty- Department of Biostatistics and Bioinformatics in UNAVAILABLE, for Emory Healthcare

Details Posted: 24-Jun-22 Location: UNAVAILABLE, Salary: Open Categories: Physicians/Surgeons Discover Your Career at Emory University Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future. We welcome candidates who can contribute to the diversity and excellence of…

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Faculty Opinions: hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible.

Rivetti di Val Cervo P et al. Nature Reviews. Neurology. 2021 06; 17(6):381-392 doi.org/10.1038/s41582-021-00465-0PMID: 33658662 Show Details AbstractAuthors Human induced pluripotent stem cells (hiPSCs) were first generated in 2007, but the full translational potential of this valuable tool has yet to be realized. The potential applications of hiPSCs are especially…

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CRISPR-Cas technology a new era in genomic engineering

Review doi: 10.1016/j.btre.2022.e00731. eCollection 2022 Jun. Affiliations Expand Affiliation 1 Department of Agriculture and Natural Resources, College of Agriculture, Science, and Technology, Delaware State University, Dover, DE 19901, United States of America. Free PMC article Item in Clipboard Review Ali Parsaeimehr et al. Biotechnol Rep (Amst). 2022. Free PMC article Show…

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Phylogenomics and species delimitation of the economically important Black Basses (Micropterus)

Arlinghaus, R. et al. Governing the recreational dimension of global fisheries. Proc. Nat. Acad. Sci. USA 116, 5209–5213 (2019). CAS  PubMed  PubMed Central  Article  Google Scholar  Cowx, I. G. & Gerdeaux, D. The effects of fisheries management practises on freshwater ecosystems. Fish. Manag. Ecol. 11, 145–151 (2004). Article  Google Scholar …

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Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity

Visscher, P. M. et al. 10 years of GWAS discovery: biology, function, and translation. Am. J. Hum. Genet. 101, 5–22 (2017). CAS  PubMed  PubMed Central  Google Scholar  Buniello, A. et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019. Nucleic Acids Res. 47,…

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Ultrasensitive, Specific, and Rapid Detection of Mycoplasma pneumoniae Using the ERA/CRISPR-Cas12a Dual System

Mycoplasma pneumoniae can cause severe respiratory tract infections and extrapulmonary diseases, which pose a significant threat to the health of children. Diagnostic methods for M. pneumoniae include isolation and culture, antibody detection, fluorescence quantitative PCR, and so on, but there are various shortcomings in time, cost, convenience, and sensitivity. In…

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Swarm immunology: harnessing blockchain technology and artificial intelligence in human immunology

Human immunology may soon benefit from the use of artificial intelligence and blockchain technologies. Here, we discuss how Swarm Learning could foster collaborative worldwide immunology studies that fully respect local data privacy regulations by sharing insights, not data. For decades, immunological research has benefited from highly standardized animal models. Yet,…

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Recent developments in miRNA based recombinant protein expression in CHO

Aguiar TQ, Santos SB, Martins IM, Domingues L, Oliveira C (2019) Production and bioengineering of recombinant pharmaceuticals. Proteins: sustainable source, processing and applications. Elsevier, Amsterdam, pp 259–293 Chapter  Google Scholar  Amadi IM, Agrawal V, Christianson T, Bardliving C, Shamlou P, LeBowitz JH (2020) Inhibition of endogenous miR-23a/miR-377 in CHO cells…

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Job Application for Bioinformatics Engineer, Pipeline (Oncology) at Invitae

Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a…

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Digital Identity Solutions Market In-Depth Analysis including Development Strategy, Regional Analysis, Key Segmentation by Major Companies like IDEMIA, ForgeRock, Imageware Systems, Jumio, NEC, Samsung SDS

“ The global Digital Identity Solutions Market is an information rich representation of the current market developments that echo upward spike in growth numbers. Our team of research experts at Adroit Market Research has relied upon dedicated primary and secondary research methodologies to make accurate deductions of the market developments,…

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CRISPRi for specific inhibition of miRNA clusters and miRNAs with high sequence homology

Bartel, D. P. MicroRNAs: Target recognition and regulatory functions. Cell 136, 215–233 (2009). CAS  Article  Google Scholar  Bassett, A. R. et al. Understanding functional miRNA–target interactions in vivo by site-specific genome engineering. Nat. Commun. 5, 4640 (2014). ADS  CAS  Article  Google Scholar  Moore, M. J. et al. miRNA–target chimeras reveal…

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RNA, tRNA, circRNA: Imagine the potential of treatment!

modern When Pfizer Made history with their mRNA COVID-19 vaccine. Vaccines have sent a new era of development of mRNA therapies, and after 11.4 billion doses, mRNA therapy is the future of treatments for many different conditions. Currently, other types of RNA therapies are also attracting attention, triggering exciting new…

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Complete sequence of human genome published in landmark achievement

Share on PinterestResearchers have published a gapless sequence of the human genome. John Niklasson/Getty Images Researchers belonging to the Telomere-to-Telomere (T2T) consortium have published the complete sequence of the human genome, filling in gaps present in previous versions. Previously published sequences accounted for 92% of the human genome and were…

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At ABRF Meeting, T2T Consortium Describes Improvements of Complete Human Genome

PALM SPRINGS, Calif. — Researchers from the Telomere-to-Telomere (T2T) Consortium have generated an assembly of a complete human reference genome that could lead to better variant calling in the clinic and inform new studies of cell biology. The results of the project were presented by Karen Miga, an investigator at…

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Bioinformatics Technologist – Ting Lab at Cleveland Clinic

req # 163929 Location Cleveland, Ohio Facilities Cleveland Clinic Main Campus Professional Area IT and Cybersecurity Department N/A Jobcode T98393 Schedule Full Time Shift 8:00am-5:00pm Under the direction of senior bioinformatics personnel, this entry level…

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Linkage mapping, comparative genome analysis, and QTL detection for growth in a non-model teleost, the meagre Argyrosomus regius, using ddRAD sequencing

Fricke, R., Eschmeyer, W. N. & van der Laan, R. (eds). Eschmeyer’s Catalog of Fishes: Genera, Species, Rererences. researcharchive.calacademy.org/research/ichthyology/catalog/fishcatmain.asp. Electronic version, Accessed 15 October 2021. Nelson, J. S. Fishes of the World 4th edn, 372 (Wiley, 2006). Google Scholar  Chen, X. H., Lin, K. B. & Wang, X. W. Outbreaks…

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Accurate assembly of multi-end RNA-seq data with Scallop2

Trapnell, C. et al. Transcript assembly and quantification by RNA-seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat. Biotechnol. 28, 511–515 (2010). Article  Google Scholar  Guttman, M. et al. Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs. Nat. Biotechnol. 28,…

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Phylogenomic analysis of Syngnathidae reveals novel relationships, origins of endemic diversity and variable diversification rates | BMC Biology

Stölting KN, Wilson AB. Male pregnancy in seahorses and pipefish: beyond the mammalian model. Bioessays. 2007;29:884–96. PubMed  Google Scholar  Whittington CM, Friesen CR. The evolution and physiology of male pregnancy in syngnathid fishes. Biol Rev Camb Philos Soc. 2020;95:1252–72. PubMed  Google Scholar  Rosenqvist G, Berglund A. Sexual signals and mating…

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South-to-north migration preceded the advent of intensive farming in the Maya region

Moreno-Mayar, J. V. et al. Early human dispersals within the Americas. Science 362, eaav2621 (2018). ADS  PubMed  Google Scholar  Posth, C. et al. Reconstructing the deep population history of Central and South America. Cell 175, 1185–1197.e22 (2018). CAS  PubMed  PubMed Central  Google Scholar  Raghavan, M. et al. Genomic evidence for…

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[Nigeria] Phase3 Telecom scales up layered security for optimized network infrastructure

[Nigeria] Phase3 Telecom scales up layered security for optimized network infrastructure 22-03-2022 11:45:00 | by: Andrea Ayemoba | hits: 498 | Tags: Independent aerial fibre optic network infrastructure and telecommunications services provider, Phase3 Telecom, has announced that it is adopting an innovative, technology-driven, digitized and multilayer approach for security operation…

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Using CRISPR/Cas to develop biosafety materials

The diagnosis and treatment of viral infections, especially those that cause large-scale outbreaks, is urgently needed, as the lack of these measures allows epidemics to progress. A new Biosafety and Health study discusses the use of the highly efficient clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas) technology to…

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Data Scientist II

Data Scientist II Overview Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the…

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When proteome meets AI, what is accelerated

What meaningful or interesting information can an ordinary person obtain by performing mass spectrometry detection of the whole blood proteome? Who will be the 23andMe (DNA identification company) in the proteome space? In July last year, when 98.5% of the protein structure of the human proteome was deciphered by the…

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BTG2 gene predicts poor outcome in PT-DLBCL

Introduction Primary testicular diffuse large B-cell lymphoma (PT-DLBCL) is a rare and aggressive form of mature B-cell lymphoma.1–3 PT-DLBCL was the most common type of testicular tumor in men aged over 60 and characterized by painless uni- or bilateral testicular masses with infrequent constitutional symptoms.4–6 PT-DLBCL shows significant extranodal tropism,…

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AlphaFold, GPT-3 and How to Augment Intelligence with AI

This is the first post in a two-part series. Read Part 2 here. Around the same time that Alan Turing was shaping his theories of machine intelligence in Manchester, another future giant of the computing world, Douglas Engelbart, was developing an alternative computing paradigm over 5,000 miles away in…

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The correlation between the levels of anti-dsDNA IgA antibody and the severity of systemic lupus erythematosus based on cutaneous vasculitis

Método el estudio transversal se realizó en las instalaciones para pacientes ambulatorios del Hospital Wahidin Sudirohusodo y el Hospital Universitario Hasanuddin en Makassar desde septiembre de 2020 hasta febrero de 2021. La investigación de los niveles de IgA anti-ds-DNA en pacientes con LES se realizó en dos grupos: grupo A…

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Nature Papers Describe Automated Genome Assembly Method, Gut Microbiome Links to Immune Checkpoint Inhibitor Response, More

A new computational method for automated genome assembly from long, high-fidelity reads is presented in Nature Biotechnology this week. While breakthroughs in genome sequencing were primarily achieved using HiFi reads, assembly of these reads remains a challenge and, in the era of population-scale sequencing, there is a need for an…

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Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene blaNDM

Wu, W. et al. NDM metallo-β-lactamases and their bacterial producers in health care settings. Clin. Microbiol. Rev. 32, e00115–18 (2019). Yong, D. et al. Characterization of a new metallo-β-lactamase gene, bla NDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14…

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Polatuzumab Vedotin Plus R-CHOP May Improve Outcomes For DLBCL Patients

Thomas Habermann, MD, discusses R-CHOP and how it can be improved upon as a treatment method for diffuse large B-cell lymphoma. Thomas Habermann, MD, a hematologist with the Mayo Clinic, discusses the combination of rituximab (Rituxan), cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) as a treatment method for diffuse large B-cell…

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H2O brings AI grandmaster-powered NLP to the enterprise

There are about 1200 chess grandmasters on the earth, and solely 250 AI grandmasters. In chess, as in AI, grandmaster is an accolade reserved for the highest tier {of professional} gamers. In AI, this accolade is given out by the top-performing knowledge scientists in Kaggle’s development system. H2O.ai, the AI…

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Generation of Hook Ischemia-Reperfusion Model using a Three-Day Developing Chick Embryo

This paper describes ischemia-reperfusion (I/R) modeling in a 3-day chick embryo using a spinal needle customized hook to better understand I/R development and treatment. This model is simple, quick, and inexpensive. Hi, I am Dr.Syed Shadab Raza, the principal investigator for the Laboratory for Stem Cells and Restorative Neurology, located…

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Deep learning and genomics: predicting gene expression from DNA sequence

The human genome is enormously complex. Before the first draft of the genome was completed in 2003, there was an optimism that knowing its sequence could smoothly translate into cures and treatments for various diseases. Unfortunately, the scientific community quickly discovered that having the DNA sequence is still many steps…

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Job Application for Bioinformatics Scientist, Assay Development at Mission Bio

Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a…

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Intern- Bioinformatics on beHired.in

The Research Data Sciences team applies its expertise to support analysis, visualization and interpretation of genomic datasets. These datasets include next-generation sequencing data as well as derived data from Pathology images and published studies. We work collaboratively with other functional teams across the company to support drug development programs in…

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Learning from Deep Learning: inspirational story behind AlphaFold

DeepMind Chief Executive visits EMBL Heidelberg to discuss current and future implications of Artificial Intelligence for life science research A delegation from DeepMind visited EMBL Heidelberg to discuss current and future implications of Artificial Intelligence for life science research (John Jumper 2nd from left, Edith Heard 6th from left, Demis…

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Job Application for Bioinformatics Engineer, Pipeline at Invitae

Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a…

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Bioconductor on Microsoft Azure – Microsoft Tech Community

Co-authored by: Nitesh Turaga – Scientist at Dana Farber/Harvard, Bioconductor Core Team Erdal Cosgun – Sr. Data Scientist at Microsoft Biomedical Platforms and Genomics team Vincent Carey – Professor at Harvard Medical School, Bioconductor Core Team   Introduction   The Bioconductor project promotes the statistical analysis and comprehension of current and emerging…

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‘JYP New Girl Group’ NMIXX (Enmix), debut trailer first released ..

JYP Entertainment (hereinafter referred to as JYP) new girl group NMIXX (Enmix) has announced the new era of K-pop with its extraordinary first appearance. JYP opened the trailer video ‘[NMIXX] Debut Trailer’ and trailer photo sequentially to announce the debut countdown of NMIXX on the official SNS channel at 0:00…

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Postdoctoral Fellow (Bioinformatics) – Jos Melenhorst Lab

Highly motivated individuals with a PhD or MD/PhD in relevant area are encouraged to apply. This training position, under the direct supervision of a Cleveland Clinic Principal Investigator will provide practical training and experience in a research setting. This position is appointed through the Lerner Research Institute. The successful applicant…

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Xenotransplantation: Argentina is about to produce genetically modified animals for human transplants

While the international medical community celebrates the first successful xenotransplantation, in Argentina two research teams from public universities are preparing to produce genetically modified animals so that their organs are suitable for human transplants and the first pigs of this type would be obtained at the end of this year…

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Deciphering Protein Structure-Dynamics-Function Relationships in the Post AlphaFold Era

AI techniques have come of age – Google DeepMind’s AlphaFold, and other competitive approaches such as RosettaFold, and the more recent efforts at folding RNA structures using Atomic Rotationally Equivariant Scorer (ARES), have enabled accurate predictions of protein and RNA three-dimensional (3D) structures starting with just their primary sequences….

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Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits

1. Jansen, I. E. et al. Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk. Nat. Genet. 51, 404–413 (2019). CAS  PubMed  PubMed Central  Google Scholar  2. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014). PubMed…

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Intern- Bioinformatics – Foster City

Gilead Sciences is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensure the…

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Toll-like receptor 2/4 in Chinese patients with sepsis

Introduction Sepsis is a life-threatening organ dysfunction that results from an exaggerated host immune response to disseminate infection.1 Despite improvements in treatment strategies, sepsis remains a leading cause of death in critically ill patients worldwide.2 Low platelet number, known as thrombocytopenia, is common in infectious diseases (also sometimes referred to…

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Gilead Sciences hiring Intern – Bioinformatics in Foster City, California, United States

Gilead Sciences is continuing to hire for all open roles. Our interview process may be conducted virtually and some roles will be asked to temporarily work from home. Over the coming weeks and months, we will be implementing a phased approach to bringing employees back to site to ensure the…

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Bioinformatics Analyst – Emory Healthcare/Emory University

Discover Your Career at Emory University Emory University is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the future.We welcome candidates who can contribute to the diversity and excellence of our academic community. Description JOB DESCRIPTION: + Maintains software, hardware…

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Real-World Assessment of Patient Care and Practice Efficiency With the Introduction of Subcutaneous Rituximab

Introduction Rituximab (Rituxan; Genentech) is a chimeric anti-CD20 monoclonal antibody widely used in non-Hodgkin lymphoma (NHL) treatment.1 Worldwide, rituximab is recommended for a variety of B-cell malignancies,1,2 and it has a well-established efficacy and safety profile, with more than 4 million patients treated.1,3 In the United States, rituximab is approved…

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The Future of Targeted Therapies in DLBCL

In an interview with Targeted Oncology, Thomas Habermann, MD discusses the current unmet needs in the DLBCL space, along with the future of targeted therapies. While rituximab (Rituxan), cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is a highly effective therapy for diffuse large B-cell lymphoma (DLBCL). However, major unmet clinical needs still exist for patients with…

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Genome-wide identification of enhancers and transcription factors regulating the myogenic differentiation of bovine satellite cells | BMC Genomics

1. Yin H, Price F, Rudnicki MA. Satellite cells and the muscle stem cell niche. Physiol Rev. 2013;93(1):23–67. CAS  PubMed  PubMed Central  Google Scholar  2. Hoppeler H, Fluck M. Plasticity of skeletal muscle mitochondria: structure and function. Med Sci Sport Exer. 2003;35(1):95–104. CAS  Google Scholar  3. Astruc T: Carcass Composition,…

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Unlocking the Cotton Genome: Space-bound Research ‘Large Step’

Clemson researcher Chris Saski admits sending the University’s iconic Tiger Paw to space aboard a SpaceX Dragon spacecraft is, quite literally, “an out-of-this-world experience.”  But it’s the potential for the experiments in the flight hardware to which the Paw is attached that truly excites him. Saski’s cotton regeneration research, adorned…

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Establishment of sunitinib-resistant CDX model of ccRCC

Introduction Renal cell carcinoma (RCC) accounts for approximately 2–3% of all malignant tumors, and its prevalence is rising. Metastatic RCC accounts for 25–30% of all RCC cases, and has an exceedingly poor prognosis.1 In 2020, among approximately 430,000 newly discovered cases of RCC, 179,000 died.2 Clear cell renal cell carcinoma…

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Towards the biogeography of prokaryotic genes

1. Sunagawa, S. et al. Structure and function of the global ocean microbiome. Science 348, 1261359 (2015). PubMed  Google Scholar  2. Zou, Y. et al. 1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses. Nat. Biotechnol. 37, 179–185 (2019). CAS  PubMed  PubMed Central  Google Scholar  3. Mohammad,…

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Role of GPs in changing landscape of fertility treatment

PRIMARY care has for years been the cornerstone of the Australian health care system and GPs represent an integral part of it. As they are frequently responsible for the first, and sometimes only, contact of individuals with the health care system, they can profoundly affect a patient’s experience, expectations and…

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Metagenomics for epidemiological surveillance in ONE HEALTH

Next-Generation Sequencing (NGS) technology has led to a new era of studying microorganisms. Using this tool, our knowledge and understanding of microbiology has expanded at a rapid pace compared to traditional methods that rely on cell culture, microscopy, serology, and polymerase chain reaction (PCR). At the community level, microorganisms…

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Senior Bioinformatics Scientist II/ Staff Bioinformatics Scientist

Inscripta was founded in 2015 and recently launched the world’s first benchtop Digital Genome Engineering platform. The company is growing aggressively, investing in its leadership, team, and technology with a recent $150mm financing round led by Fidelity and TRowe price. The company’s advanced CRISPR-based platform, consisting of an instrument, reagents,…

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The $11-billion Webb telescope aims to probe the early Universe

Lisa Dang wasn’t even born when astronomers started planning the most ambitious and complex space observatory ever built. Now, three decades later, NASA’s James Webb Space Telescope (JWST) is finally about to launch, and Dang has scored some of its first observing time — in a research area that didn’t…

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Identification of lipid metabolism-associated gene signature

Background Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer. Despite the dramatic improvement in breast cancer prognosis due to recent therapeutic advances, such as more effective adjuvant and neo-adjuvant chemotherapies, together with more radical and safer surgery, advances in early diagnosis and treatment over the…

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Sr. Research Scientist I, Bioinformatics job with Gilead Sciences, Inc.

Sr. Research Scientist I, BioinformaticsUnited States – California – Foster City Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with…

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Job vacancy in Global Worldwide: Part-Time Bioinformatics Analyst, Vision Research at Emory University

Job details Job type full-time Full job description Discover your career at emory university: emory university is a leading research university that fosters excellence and attracts world-class talent to innovate today and prepare leaders for the futureWe welcome candidates who can contribute to the diversity and excellence of our academic…

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Scientists Say They Could Bring Back Woolly Mammoths. But Maybe They Shouldn’t | THE DAILY TRIBUNE

Agencies | Washington The Daily Tribune – www.newsofbahrain.com Using recovered DNA to “genetically resurrect” an extinct species — the central idea behind the Jurassic Park films — may be moving closer to reality with the creation this week of a new company that aims to bring back woolly mammoths thousands of years…

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Principle Investigators in lifeomics, bioinformatics, data science and AI in biomedicine

The National Center for Protein Sciences (Beijing) (NCPSB), also known as the PHOENIX Center(Pilot Hub Of ENcyclopedic proteomIX) is a leading science and technology infrastructure for biomedical research in China. Approved and jointly built by the State and Beijing local governments, the Phoenix Center currently harbors the world’s largest cutting-edge…

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Transcriptome assembly, annotation and submission to GenBank for unannotated organisms

Monday, October 4 at 3:00pm to 4:00pm Virtual Event Transcriptome assembly and annotation is a complex process that requires the integration of multiple databases using several computational tools for best results. The advances in next-generation sequencing technologies and the decrease in the cost of sequencing a complete transcriptome are driving…

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A Day in the Life of a Genetic Counselor in the Yale Genetics Department

Genetic counselors bridge the gap between the technical, scientific information of a genetic disease diagnosis or test result and the patient’s understanding of how their genetic information affects their health. With the widespread use of DNA sequencing in cancer and increasingly more conditions in the age of precision medicine, genetic…

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