Tag: FAIR

Turncoat T cells are at the core of multiple sclerosis and other inflammatory central nervous system disorders

scRNAseq replicates. CD45.1+ P14 cells were adoptively transferred into adult CD45.2+ GP or GFAP:GP mice 24h before i.c. infection with rLCMV-GP33. At least six weeks later, mice were treated with antiCD8a depleting antibody or isotype control. One week after depletion, mice were treated with TAM i.p. for four consecutive days…

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Unexpected behaviour during hybrid Monte-Carlo simulations (ReaxFF) – LAMMPS Beginners

T.Dem June 25, 2022, 5:41pm #1 Dear LAMMPS users, I am trying to run Monte Carlo simulations using reaxff to study the oxygen coverage on a Pt nanoparticle. I defined my oxygen reservoir using the chemical potential definition for a perfect gas. Initially, the system is very small (350 atoms)…

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Hubble captures a galactic menagerie

Credit: ESA/Hubble & NASA, H. Ebeling; Acknowledgment: L. Shatz The NASA/ESA Hubble Space Telescope captured this massive galaxy cluster, called Abell 1351, with its Wide Field Camera 3 and Advanced Camera for Surveys. Abell 1351 lies in the constellation Ursa Major in the northern hemisphere. This image is filled with…

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Researchers use nanotechnology to destroy and prevent relapse of solid tumor cancers

Generation and characterization of DCNV-rAd-Ag. a, Generation of DCNVs derived from adenovirus-infected mature dendritic cells. (1) The genes of tumor-specific antigen were genetically engineered into the adenovirus vector. (2) Recombinant adenovirus infected the immature DC2.4 cells to express the modified antigen on the cell surface and stimulate it. (3) Differentiation,…

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Cas12c provides antiviral immunity without the need to cut DNA

Graphical abstract. Credit: Molecular Cell (2022). DOI: 10.1016/j.molcel.2022.04.020 A trio of researchers at the University of California, Berkeley, has found that the protein Cas12c can provide antiviral immunity for bacteria without the need to cut DNA. In their paper published in the journal Molecular Cell, Carolyn Huang, Benjamin Adler and…

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New gene-edited tomatoes boost vitamin D levels

An international team of scientists primarily based out of the John Innes Centre in the United Kingdom has used gene-editing to create a vitamin D-enriched tomato. Using CRISPR-Cas9, they switched off an enzyme in tomatoes that ordinarily prevents the molecular forerunner of vitamin D3 (called 7-dehydrocholesterol, or 7-DHC) from accumulating…

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First genomic sequencing of monkeypox from Switzerland is now available

The virus can be identified with a PCR test, especially from affected lesions and other samples. Credit: Geneva University Hospitals (HUG) The Geneva Centre for Emerging Viral Diseases shares the first sequencing results of the monkeypox genome from Switzerland. This important step will enable further analysis and comparison with genome…

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How a genetic mutation affects the body’s immune system response to viruses, development of blood cancers

Graphical abstract. Credit: Cell Reports (2022). DOI: 10.1016/j.celrep.2022.110856 The body’s innate immune system, active from birth, is the first line of defense against viruses and other pathogens that cause disease. Using vaccination as an example, after receiving a vaccine, pain, redness, or swelling may occur at the injection site. This…

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CENTURY THERAPEUTICS, INC. Management’s discussion and analysis of financial condition and results of operations (form 10-Q)

The following discussion and analysis should be read in conjunction with our financial statements and accompanying notes included in this Quarterly Report on Form 10-Q and the financial statements and accompanying notes thereto for the fiscal year ended December 31, 2021 and the related Management’s Discussion and Analysis of Financial…

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Molecular mechanism of ZDHHC18-mediated palmitoylation of cGAS in innate immunity inhibition

Detection of double-stranded DNA by cGAS triggers innate immune responses. ZDHHC18-mediated palmitoylation of cGAS sheds light on a novel posttranslational modification that leads to the fine-tuning of cGAS-mediated innate immune responses. Credit: The EMBO Journal (2022). DOI: 10.15252/embj.2021109272 Cyclic GMP-AMP synthase (cGAS), a double-stranded DNA (dsDNA) sensing protein, plays an…

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Cogent Biosciences Reports Recent Business Highlights and First Quarter 2022 Financial Results

Cogent Biosciences, Inc. Initial bezuclastinib APEX data to be presented at the European Hematology Association (EHA) 2022 Annual Congress Building a portfolio of discovery stage programs, creating potential best-in-class small molecule kinase inhibitors for genetically defined oncology indications and rare diseases Ended 1Q 2022 with $191.0 million in cash, sufficient…

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Production Bioinformatics Manager, Clinical Informatics (Operations)

Invitae is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. The Clinical Informatics team is driven to make a difference for the patients we serve. We are leading the transformation of the genetics industry by making genetic testing affordable and accessible for…

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Team develops method to increase gene editing efficiency while minimizing DNA deletion sizes

Targeting E. coli DNA pol I to DSBs increased the ratio of 1-bp deletions versus >1-bp deletions and TIS versus non-TIS. (A) Counteracting DNA resection (e.g. MRE11) by pol I fused to Cas9. The expected result is suppression of the MMEJ and SSA DNA repair pathways, which require DNA resection. (B)…

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Unlocked enzyme structure shows how strigolactone hormone controls plant growth

Using a permanently unlocked form of the plant enzyme MAX3, UC Davis researchers are exploring the mechanism by which the plant hormone strigoractone regulates a massive network of genes controlling plant growth and architecture. Credit: Nitzan Shabek/UC Davis As sessile organisms, plants have to continually adapt their growth and architecture…

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Job Hunting? New Jersey Is Hiring Thousands for Its Brand New Marijuana Industry

nattrass / Getty Images/iStockphoto Recreational marijuana sales are now officially legal in New Jersey, and the industry is staffing up to meet demand. The Garden State already has nearly 3,150 full-time jobs supporting $189 million in statewide sales, NJ.com reported, citing comments from Bruce Barcott, senior editor and executive producer…

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Skill-Based Hiring Could Address Technical Staffing Shortages

A Harvard Business Review study found that, to meet the demand for experienced tech staff to drive digital transformation efforts, many companies have adopted skill-based hiring (vs. hiring based on degrees). Such an approach complements automation efforts that try to make efficient use of a staff’s time. In the mid-2010s,…

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Euro-BioImaging Bio-Hub – FAIR Image Data Steward at European Molecular Biology Laboratory (EMBL)

About the team/job Euro-BioImaging ERIC (www.eurobioimaging.eu) is a leading pan-European research infrastructure that provides the research community open access to cutting-edge imaging services. The Euro-BioImaging Bio-Hub hosted by European Molecular Biology Laboratory (EMBL) is looking for a highly motivated FAIR Image Data Steward to develop general guidelines and technically support…

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Bioinformatics Data Engineer in Boston, MA for Dana-Farber Cancer Institute

Details Posted: 27-Apr-22 Location: Boston, Massachusetts Salary: Open Categories: Staff/Administrative Internal Number: 2022-26005 Located in Boston and the surrounding communities, Dana-Farber Cancer Institute (DFCI) brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people…

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DCGI emergency use nod for Covaxin, Corbevax and ZyCoV-D across age groups

The Drug Controller General of India (DCGI) on Tuesday granted emergency use approvals to COVID-19 vaccines Covaxin, Corbevax and ZyCoV-D. While the emergency use authorisation (EUA) was granted to Bharat Biotech’s Covaxin for the age group of 6-12 years, Biological E’s Corbevax bagged the nod…

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Research team follows nearly 8,000 paths towards better cell factories

Saccharomyces cerevisiae, SEM image. Credit: Mogana Das Murtey and Patchamuthu Ramasamy/CC BY-SA 3.0 Microorganisms that efficiently convert plant biomass into renewable biofuels and biochemicals play a major role in the sustainable society of the future. However, the efficiency of these microbial cell factories is inhibited by several compounds that are…

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Unit Manager – Bioinformatics and Genomic Epidemiology

MPHI is a Michigan-based and nationally engaged, non-profit public health institute.  We are a team of teams, process and content experts, dedicated to building A world where tomorrow is healthier than today!   Title:                              Unit Manager – Bioinformatics and Genomic Epidemiology                                        $66,100 – $97,200 / Posted Thru:  4-28-22   Location: …

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14 Postdoctoral Fellowship at Umea University, Sweden

Umea University, Sweden invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at Umea University, Sweden. Eligible candidate may Apply as soon as possible.   (01) Postdoctoral Fellowship Position Postdoc Fellowship Position summary/title: Postdoctoral fellow – Molecular epidemiology…

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Do preteens really need an HPV vaccine?

by Dr. Rebekah Fenton and Dr. Rebecca Perkins Gardasil vaccine and box. Image: Wikipedia Q: Why is it important for my 10-year-old to get the HPV vaccine? A: If you are the parent of a preteen who is between the ages of 9 and 12, it’s time to make sure…

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[Solved] ggplot with 2 y axes on each side and different

Sometimes a client wants two y scales. Giving them the “flawed” speech is often pointless. But I do like the ggplot2 insistence on doing things the right way. I am sure that ggplot is in fact educating the average user about proper visualization techniques. Starting with ggplot2 2.2.0 you can…

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Fix error handling in pcm030_fabric_probe

[PATCH] ASoC: fsl: Fix error handling in pcm030_fabric_probe * [PATCH] ASoC: fsl: Fix error handling in pcm030_fabric_probe @ 2022-03-01 7:53 Miaoqian Lin 2022-03-02 13:44 ` Mark Brown 0 siblings, 1 reply; 7+ messages in thread From: Miaoqian Lin @ 2022-03-01 7:53 UTC (permalink / raw) To: Liam Girdwood, Mark Brown,…

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UCSC and Amazon Web Services work to accelerate genomics research

The UC Santa Cruz Genomics Institute is collaborating with Amazon Web Services (AWS) to allow researchers to quickly and efficiently execute bioinformatics pipelines on AWS’s global cloud infrastructure. AWS and UCSC are committed to accelerating genomics research by integrating the Dockstore project, a leading repository for scientific and biomedical workflows…

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FAIR trees: phylogenetics in Galaxy workshop Tickets, Wed 15 Jun 2022 at 09:00

Currently, phylogenetic analysis using sequence data involves many steps using various bioinformatic tools. This translates into a steep and long learning curve for researchers with little bioinformatic knowledge since the majority of these tools run on the command line. Galaxy is an open-source, free platform for FAIR data analysis that…

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A new technique to unravel gene regulation

Zebrafish notochord nuclei at 15-somite stage. Grey: nuclear DNA (DAPI). Color: histone H3K9me3. Credit: Phong Nguyen, Franka Rang & Kim de Luca. How is the activity of genes regulated by the packaging of DNA? To answer this question, a technique to measure both gene expression and DNA packaging at the…

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Study shows strong influence of external environment on fungal communities in the primate gut

Illustration of bacteria in the human gut. Credit: Darryl Leja, National Human Genome Research Institute, National Institutes of Health Researchers are starting to understand the importance of gut fungi in mammals and the ways different environmental factors can shape these fungal communities, which play a crucial role in regulating immune…

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What is ClustalW? Tutorial of How to Use ClustalW

Share Tweet Share Share Email ClustalW is a computer tool of significant importance in bioinformatics. Primarily, biologists and statisticians used it for multiple sequence alignment. Many versions of ClustalW over the development of the algorithm are available now. How to perform a search on ClustalW? ClustalW homepage 1. Go to…

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Bioinformatics Scientist – GWAS – Invitae

Invitae is a rapidly growing, purposeful company. Our mission is to empower doctors and patients with genetic information to help them make informed medical decisions at all stages of life. The Integrated Risk Assessment Platform plays a meaningful role in rapidly growing our understanding of genomic health and personalized medicine….

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Two drugs show promise in rejuvenating lung epithelial progenitor cells damaged by COPD

Overview of the transcriptomics-guided drug discovery strategy.(A) Schematic outline of the drug screening strategy. (B) Heatmap shows the gene expression pattern of the druggable genes (www.dgidb.org) identified both in CS-exposed mice and patient with COPD databases. (C) Reactome pathway enrichment analysis of genes differentially expressed from patients with COPD (8)…

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Genomic sequencing aids the global tuberculosis fight

Total number of isolates for each drug by sensitivity. Each drug is represented by a colored circle weighted by the prevalence of phenotypic resistance to that drug. The center of each circle shows the intersection between values on the x-axis and y-axis. Group 1 = associated with resistance. Group 2…

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Team develops new process for evaluating impacts of gene edits that alter rather than ‘knock out’ DNA code

CRISPR-associated protein Cas9 (white) from Staphylococcus aureus based on Protein Database ID 5AXW. Credit: Thomas Splettstoesser (Wikipedia, CC BY-SA 4.0) A new study from scientists at ChristianaCare’s Gene Editing Institute is advancing the safety and efficacy of using CRISPR gene editing in patient treatments by demonstrating how to identify and…

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A-Prot: protein structure modeling using MSA transformer | BMC Bioinformatics

Benchmarking contact prediction First, we benchmarked the long-range contact prediction performance of A-Prot using the FM and FM/TBM targets of CASP13 [24]. The benchmark results show that the performance of our model outperforms that of the existing methods (Table 1). We compared the precision of our model’s top L/5, L/2,…

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An R package for comprehensive data analysis of peptide- and protein-centric bottom-up proteomics data

Overview of protti functions. protti can be used on the output of any software package for quantitative analysis of bottom-up proteomics experiments and provides a flexible set of functions for quality control, as well as data pre-processing, data analysis and data interpretation. Credit: Bioinformatics Advances (2021). DOI: 10.1093/bioadv/vbab041 A recent…

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Crystallography, cryo-EM and AlphaFold shed light on key human antibacterial proteins

Figure 1. Model of the human UMOD/FimH interaction, assembled by combining the structural information described in the study. A, The high-mannose sugar chain (green) of the decoy modules branching out from a filament of UMOD (shades of blue) is bound by the FimH sugar-binding domain at the tip of bacterial…

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Family History Fair Held In M.V.

By CRAIG HIGGINS The Progress Local storyteller and personal historian Charlene Paul teaches a class at the Moapa Valley Family History Fair on Saturday, Feb. 26. PHOTO BY CRAIG HIGGINS/The Progress Local residents had an opportunity to make a connection with their ancestors on Saturday, Feb. 26, at the annual…

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Research Biologist Computational Bioinformatics Geneticist Research Associate Job in PEORIA, IL

Summary The Agricultural Research Service (ARS) is the United States Department of Agriculture’s chief scientific research agency and one of the world’s premiere scientific organizations. ARS Postdoctoral Research Associates are hired to supplement a lead scientist’s research on agricultural problems of high national priority affecting American agriculture. **ANNOUNCEMENT IS OPEN…

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Using AnnoTree to Get More Assignments, Faster, in DIAMOND+MEGAN Microbiome Analysis

INTRODUCTION Next-generation sequencing (NGS) has revolutionized many areas of biological research (1, 2), providing ever-more data at an ever-decreasing cost. One such area is microbiome research, the study of microbes in their theater of activity using metagenomic sequencing (3). Here, deep short-read sequencing, and improving performance of long-read sequencing, are…

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Admissible Machine Learning w/E LeDell, Chief Machine Learning Scientist, H2O.ai

Erin Ledell is Chief Machine Learning Scientist at H2O.ai, the company that produces the open source, distributed machine learning platform, H2O. At H2O.ai, she leads the development of the H2O AutoML algorithm. She is also the founder of WiMLDS and co-founder of R-Ladies Global. Talk will cover: Admissible Machine Learning…

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UH Manoa Campus Events Calendar

Scientific Workflows and Gateways February 18, 2:00pm – 4:00pm Mānoa Campus, In Person at 103 Keller Hall, UH Manoa or Online via Zoom Workshop Description Sciences are becoming more data intensive and thus managing, handling and exploring data are becoming more prevalent issues in research. Using these data sets…

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h2o AutoML vs h2o XGBoost – model metrics

The problem here is that you are comparing training metrics for XGBoost to CV metrics for AutoML models. The code you posted for the manual XGBoost models provides training metrics. Instead, you will need to grab the CV metrics if you want to make a fair comparison to the performance…

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Bioinformatics Scientist Job Opening in Seattle, WA at Alpine Immune Sciences

Job Posting for Bioinformatics Scientist at Alpine Immune Sciences Alpine Immune Sciences is applying our platform discovery technology to bring innovative new therapies to people living with serious or life-threatening illnesses or conditions, such as cancer and autoimmune/inflammatory diseases. Exciting challenges lie ahead—guided by our core values, we’ll…

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r – Where does ggplot set the order of the color scheme?

I think this is a reproducible example of what you’re seeing. In the diamonds dataset, the mean price of “Good” diamonds is actually higher than the mean for “Very Good” diamonds. library(dplyr) diamonds %>% group_by(cut) %>% summarize(mean_price = mean(price)) # A tibble: 5 x 2 cut mean_price <ord> <dbl> 1…

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Scientists identify promising transmission chain breakers in the fight against malaria

Credit: CC0 public domain Blocking important proteins found in Anopheles gambiensis, the leading carrier of malaria transmission to humans in Africa, blocks malaria parasite transmission and parasite humans, according to researchers at Johns Hopkins Malaria Research. You can prevent infection to. Johns Hopkins Bloomberg Institute for Public Health School. and…

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Senior Bioinformatics Software Developer – Bethesda

Medical Science & Computing, (MSC), a Dovel company, is seeking skilled Senior Bioinformatics Software Developers to join our team supporting our client, NCBI at the National Institutes of Health, (NIH) in Bethesda, MD. The National Center for Biotechnology Information (NCBI) is part of the National Library of Medicine (NLM) at…

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Increasingly efficient production of human pluripotent stem cells

Reliable production of high-quality iPS cells enables their increasingly efficient utilization in biomedical applications. Credit: Ras Trokovic, University of Helsinki Researchers at the University of Helsinki have developed a new, faster and more reliable technique for reverting human cells to the stem cell state. Pluripotent stem cells are a key…

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Multi-organoid system to simulate human liver-islet axis in normal and type 2 diabetes

Schematic of hiPSCs derived multi-organoid-on-chip system to model human liver-pancreatic islet axis in vitro. Credit: Tao Tingting Type 2 diabetes (T2DM) is a systematic multi-organ metabolic disease, which is characterized by dynamic interplay among different organs. Pancreatic islet-liver axis is closely associated with normal glucose regulation and homeostasis maintenance. The…

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High school student learning ML with a short-term goal of placing top on Kaggle? : learnmachinelearning

I’m an 11th grade student who’s fairly interested in machine learning and the AI industry. I have coding experience but haven’t learned ML yet. My short term goal is to place high on a Kaggle competition because there aren’t that many tangible goals I can place as a high school…

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Functioning induced liver cells from skin tissue

Figure 1. Urea metabolism is impaired in patient-derived human-induced pluripotent stem cells (hiPSCs) differentiated into hepatocytes (hiPSC-Heps). (A) Scheme showing the urea cycle detoxifying ammonia (NH4+) into nontoxic urea in five consecutive urea cycle enzyme (UCE)–mediated reactions in mitochondria in hepatocytes. (B) Urea secretion in four control hiPSC-Hep lines (Ctrl_1-4)…

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Genetic strategies reverse pesticide resistance

Nature Communications i>In a new empirical study published in, a gene drive designed to bias heredity, called an allelic drive, was applied without pesticide treatment to create natural-level insects that were balanced with pesticide susceptibility. Population that has been shown to be recoverable. Credits: Bier Lab, University of California, San…

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PyTorch’s Cult Following

PyTorch’s popularity spread only three years after its launch: the open-source ML library posted a 194% user growth in the first half of 2019. Since then PyTorch has not looked back. According to the survey by Stackoverflow, while TensorFlow is the most in-demand library, PyTorch is more preferred. Data from…

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Genome research: Finding the invisible

Fig. 1: Ladder-seq uses mRNA length information to aid transcriptome reconstruction. Credit: DOI: 10.1038/s41587-021-01136-7 LMU researchers have developed a method to extract more information from sequencing data. This will afford deeper insights into biology. Higher organisms store their genetic material in the nuclei of cells as deoxyribonucleic acid (DNA). In…

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The membrane structure of inner ear protein prestin is revealed

Force spectroscopy of prestin, the motor protein in the inner ear. Credit: Kanazawa University As mammals, we have very sensitive hearing, thanks to a process known as cochlear amplification. This amplification is down to sensory cells in the inner ear called outer hair cells (OHCs), and it is thought to…

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Researchers identify new bacteria and viruses on human skin

Data representing the diverse range of microbes found in the human skin microbiome. Credit: Karen Arnott/EMBL Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), the National Institutes of Health (NIH) National Human Genome Research Institute (NHGRI), the NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases, and colleagues have identified…

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Postdoctoral Scientist – Knott Lab – Bioinformatics & Functional Genomics

Requisition # HRC0544032C Principal Investigator, Simon Knott, PhD is looking for a Postdoctoral Scientist to join the team! The Cedars-Sinai Center for Bioinformatics and Functional Genomics (CBFG) is an integrated, interdisciplinary research group with the common goal of developing end-to-end research workflows for genomic and high-throughput functional analysis of patient…

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Researchers identify new bacteria and viruses in human skin

Data representing a variety of microorganisms found in the human skin microflora. Credits: Karen Arnott / EMBL Researchers and colleagues at EMBL’s European Bioinformatics Institute (EMBL-EBI), National Institutes of Health (NIH) National Institute for Human Genome (NHGRI), NIH National Institute for Arthritis, Musculoskeletal and Skin Diseases are new bacteria and…

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The direction of your DNA may be as important as which parent it came from

Fig. 1: H19 gene expression was derepressed on the paternally inherited inverted-ICR allele in fetal livers but not in placentas. a Breeding scheme. In order to distinguish parental origin of the alleles by using SNPs between inbred mouse strains, inverted-ICR heterozygous male mice (WT/INV; C57BL/6J [B6] background) were mated with…

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First time genome editing made possible on cells lining blood vessel walls

Credit: Pixabay/CC0 Public Domain The lab of Youyang Zhao, Ph.D., from Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which are cells that line blood vessel walls. This is…

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Introduction to Generative Adversarial Networks with PyTorch

Introduction to Generative Adversarial Networks with PyTorch. A comprehensive course on GANs including state of the art methods, recent techniques, and step-by-step hands-on projects What you’ll learn How Generative Adversarial Networks work internally How to implement state of the art GANs techniques and methods using PyTorch How to improve the…

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The Hot Topic In Probabilistic Programming

One of the biggest challenges of this decade is solving uncertainty, ethical and explainable problems in the thousands of machine learning models we interact with daily. Meta, formerly Facebook, announced the release of their supplement to aid this developing sphere. Bean Machine, Meta’s probabilistic programming system, is a PyTorch-based model…

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Brem Looks at Multiple Treatments for Patients With DLBCL

During a Targeted OncologyTM Case-Based Roundtable event, Elizabeth A. Brem, MD, an assistant professor in Division of Hematology/Oncology, Department of Medicine at UC Irvine Health in Los Angeles, CA, moderated a discussion about a 43-year-old woman with diffuse large B-cell lymphoma. Targeted Oncology™: What therapeutic options would you consider at…

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A year of ToBRFV

Although 2021 was the year of viruses for the entire world population, it was even more so for growers, who were confronted with the infamous Tomato Brown Rugose Fruit Virus (ToBRFV). It has been quite a ride – which is, unfortunately, not over just yet. In order to give you…

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Barriers to Loncastuximab Before CAR T-Cell Therapy in DLBCL

DISCUSSION QUESTIONS Do you foresee any barriers to using loncastuximab tesirine (Zynlonta) in diffuse large B-cell lymphoma (DLBCL)?​ If loncastuximab were covered by insurance, would you use it in the second line for patients who decline transplant?​ DEVA NATHAN, MD: I have different question. Are you willing to replace R-CHOP [rituximab…

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Translocations on chromosome 6 cause abnormalities during meiosis, resulting in fewer watermelon seeds

Credit: Unsplash / CC0 public domain Watermelon (Citrullus lanatus) is an economically important horticultural crop and one of the top five most widely consumed fresh fruits in the world. Compared to traditional seedless watermelons, seedless watermelons are preferred by consumers, show better fruit quality and bring greater economic benefits to…

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BioSpace hiring Bioinformatics Scientist in Bethesda, Maryland, United States

We are currently searching for a Bioinformatics Scientist to provide support services to satisfy the overall operational objectives of the Center for Alzheimer’s and Related Dementias, National Institute on Aging. The primary objective is to provide services and deliverables through performance of support services. This opportunity is full-time, and it…

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Human microRNA inhibits expression of pathogenic gene underlying facioscapulohumeral muscular dystrophy

Fig. 1: miR-675 targets the DUX4 ORF and 3′UTR. a RenLuc-DUX4-FL dual-luciferase reporter and CMV.H19 constructs, and U6.MIR675, H1.MIR675, U6.MIR675-3p, and U6.MIR675-5p miRNAs. RenLuc-DUX4-FL contains DUX4 ORF and 3′UTR sequences fused to Renilla luciferase after the stop codon. Exons 1–3 are indicated (Ex1,2,3). *SD5 indicates silent mutation of a cryptic…

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Promising new treatment for patients with diffuse large B-cell lymphoma

Hodgkin lymphoma, nodular lymphocyte predominant (high-power view) Credit: Gabriel Caponetti, MD./Wikipedia/CC BY-SA 3.0 A study from Memorial Sloan Kettering Cancer Center (MSK) published today in the New England Journal of Medicine (NEJM), found that in patients with previously untreated Diffuse Large B-Cell Lymphoma (DLBCL) Polatuzumab vedotin with Rituximab, Cyclophosphamide, Doxorubicin,…

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laboratory jobs in germany

We wish you a good luck and have a prosperous career. Working at Labcorp | Jobs and Careers at Labcorp 15 GNeuS Postdoc Positions in Neutron Science of 24 Months Each (Full-time Job) FZJ – Forschungszentrum Jülich. What other similar jobs are there to Laboratory jobs in Germany? Clinical Laboratory…

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Code of Conduct | PyTorch-Ignite

In the interest of fostering an open and welcoming environment, we as contributors and maintainers pledge to make participation in our project and our community a harassment-free experience for everyone, regardless of age, body size, disability, ethnicity, sex characteristics, gender identity and expression, level of experience, education, socio-economic status, nationality,…

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Fairring (FAIR + Herring) is a plug-in for PyTorch that provides a process group for distributed training that outperforms NCCL at large scales

TL;DR: Using a variation on Amazon’s “Herring” technique, which leverages reduction servers, we can perform the all-reduce collective faster than NCCL: up to 2x as fast as NCCL in microbenchmarks up to 50% speedup in end-to-end training workloads You can use it right away in your project, with no code…

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BioSpace hiring Bioinformatics Python Developer in Rockville, Maryland, United States

We are currently searching for a Bioinformatics Python Developer to provide support to the National Institutes of Health (NIH). This opportunity is a permanent, full-time position with MSC, and it is on-site in Rockville, MD. Duties & Responsibilities The role will be responsible for developing and extending software solutions for…

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New biosensor sheds light on CRISPR gene editing

ORNL’s biosensor system reveals the CRISPR activity of poplar plants that glow bright green under UV light compared to normal plants that appear red.Credits: Guoliang Yuan / ORNL, US Department of Energy Using technology developed at the Oak Ridge National Laboratory of the Department of Energy, it is now possible…

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New biosensors shine a light on CRISPR gene editing

ORNL’s biosensor system reveals CRISPR activity in poplar plants, which glow bright green under ultraviolet light, compared to normal plants, which appear red. Credit: Guoliang Yuan/ORNL, U.S. Dept. of Energy Detecting the activity of CRISPR gene editing tools in organisms with the naked eye and an ultraviolet flashlight is now…

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Nanotechnology for genome editing in multiple muscles simultaneously

Fig. 1: LNP-mediated Luc-mRNA or CRISPR-Cas9 mRNA/sgRNA delivery into muscle tissue. a Schematic illustration of LNP-CRISPR. Either Luc mRNA or Cas9 mRNA/sgRNA is encapsulated into LNP that consists of TCL053, DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycol-dimyristoyl glycerol), and cholesterol. b Chemical structure of the newly synthesized ionizable lipid, TCL053. c Representative…

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A gallery of human RNA polymerases

The Müller group’s research provides the most detailed structural information yet about human RNA polymerase I. Cryo-electron microscopy has significantly improved as a powerful tool, offering scientists greater insight into what this enzyme looks like and how it works in human cells. Credit: Müller group/EMBL Using state-of-the-art technology and techniques,…

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Using DNA to study fungal communities

This Pinus banksiana forest with a rich Arctostaphylos uva-ursi and Vaccinium sp. understory was a collection site in this study examining how disturbance affects fungal community diversity, while simultaneously testing how sequencing methods compare in characterizing communities of plant root symbionts. Credit: Natalie Scott Fungi tend to be absent in…

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An exercise-regulated noncoding RNA counteracts muscle aging

Credit: CC0 public domain In a collaborative effort between EPFL, NTNU Norway, and CBMR Danish laboratories, researchers investigated the molecular effects of exercise on non-coding RNA genes in skeletal muscle. Scientific translation medicine.. In this study, they discovered the long non-coding RNA “CYTOR” and investigated its role in rodent, worm,…

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Does use of electronic devices affect mental traits?

Credit: CC0 Public Domain In a study published in Addiction Biology, investigators found significant associations between use of electronic devices and signs of depression and anxiety, as well as cigarette smoking and alcohol drinking. The team also found certain genetic variants that were linked with these traits. The study included…

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Improving DNA storage with nanoscale electrode wells

DNA data storage requires higher synthesis throughput than is possible with current techniques. (A to D) Overview of the DNA data storage pipeline. (A) Digital data are encoded from their binary representation into sequences of DNA bases, with an identifier that correlates them with a data object, addressing information that…

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Post-Doctoral position : Virus Genomic Epidemiology / Bioinformatics – Institut Pasteur de Paris – Virologie – job portal

Emploi Équipe: Génomique évolutive des virus à ARN Équipe: Hub de Bioinformatique et Biostatistique Centre de Référence: Virus Influenzae Département de: Virologie Membre : Etienne Simon-Loriere Membre : Christophe Malabat Domaines Scientifiques Maladies Organismes Technique Date limite pour l’application 31 Dec 2021 The National Reference Center for viruses of respiratory…

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RNA-targeting enzyme expands the CRISPR toolkit

McGovern Fellows Jonathan Gootenberg (left) and Omar Abudayyeh in their lab. Credit: Caitlin Cunningham Researchers at MIT’s McGovern Institute for Brain Research have discovered a bacterial enzyme that they say could expand scientists’ CRISPR toolkit, making it easy to cut and edit RNA with the kind of precision that, until…

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What does it mean BLASTx in de novo RNAseq analysis?

What does it mean BLASTx in de novo RNAseq analysis? 1 Hi, all. I try to get an assembly stat. According to some articles, it tends to have information that can be obtained by BLAST. For example, “Top BLASTx-hit species” and “Percent of gene with at least one BLASTx hit…

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CVC Files Opposition to ToolGen Substantive Motion No. 1 | McDonnell Boehnen Hulbert & Berghoff LLP

On July 15th, Junior Party the University of California/Berkeley, the University of Vienna, and Emmanuelle Charpentier (collectively, “CVC”) filed its Opposition to Senior Party ToolGen’s Substantive Motion No. 1 for benefit of priority to U.S. Provisional Application No. 61/837,481, filed June 20, 2013 (“P3” or “ToolGen P3”), or alternatively, International…

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Cristae-dependent quality control of the mitochondrial genome

S. cerevisiae cells distinguish between WT and mutant mtDNA. (A) Schematic illustration of the pedigree analysis. Two Δarg8 yeast strains harboring WT or Δcob::ARG8 mtDNA were mated. Zygotes were isolated, and daughter cells from up to five consecutive generations were separated and placed on free spots on the agar plate…

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Lake Superior Has Seen Half A Dozen Blue-Green Algae Blooms This Year

A decade ago, a blue-green algae bloom had never been reported on Lake Superior. Now, half a dozen blue-green algae blooms have been reported this summer across Lake Superior, including one that formed recently in Superior. But researchers say the blooms were relatively minor.  The Wisconsin Department of Natural Resources is…

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The faces of three ancient Egyptians appeared thanks to the remains of DNA more than 2,000 years ago

The faces of three ancient Egyptians are brought back to life thanks to DNA group of scientists Recreate The faces of three ancient Egyptian men using DNA that is more than 2,000 years old. According to the magazine NEWSWEEKIt is believed that this is the first time that modern techniques…

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MD Anderson Cancer Center hiring Research Assistant I – Bioinformatics in Houston, Texas, United States

SummaryThe primary purpose of the Research Assistant I position is to provide expertise in bioinformatics and biostatistics regarding the crucial link between raw data and its use by the biologist/physician requesting the research study, while adhering to standard operating procedures. CORE VALUES Caring Behaviors Courtesy: Is respectful and courteous to…

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Our immune system is as unique as a fingerprint or our DNA

Double-stranded DNA fragment. Credits: Vcpmartin / Wikimedia / CC BY-SA 4.0 Everyone seems to have a completely unique immune system. Researchers at Utrecht University discovered this immune diversity after mapping antibodies from healthy and sick people. This finding may help explain, for example, why the corona vaccine appears to be…

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How climate change could impact algae in the global ocean

Scientists sample a brown mat of aggregated phytoplankton. Credit: Katrin Schmidt Global warming is likely to cause abrupt changes to important algal communities because of shifting biodiversity ‘break point’ boundaries in the oceans—according to research from the University of East Anglia and the Earlham Institute. A new study, published today…

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Dnaman software manual

Dnaman software manual DNADynamo DNA Sequence Analysis SoftwareCLC Genomics Workbench – Qiagen They have sent a man to locate the key. He was making notes with a slim gold pen on a Gucci pad? When I married my husband, that all…

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Invitae hiring Bioinformatics Scientist/Engineer in San Francisco, California, United States

Invitae is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Our team is driven to make a difference for the patients we serve. We are leading the transformation of the genetics industry, by making genetic testing affordable and accessible for everyone to…

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FTC to take on Trump’s vertical merger guidelines

With help from John Hendel and Leah Nylen — Agency agenda: The FTC plans to rescind Trump-era vertical merger guidelines at today’s open meeting. But how much will that really change? — Broadband moves: As House committees wrap up their portions of Democrats’ social spending package , some lawmakers are…

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Sports Field Breeding Gets a Boost

University of Oklahoma Gaylord Family Oklahoma Memorial Stadium, located in Norman, Oklahoma. Source: Pure Seed Mowing down the competition takes effort, but breeding turfgrass for athletic fields brings a new, creative challenge to the industry. Attitudes about the appropriate playing surface for athletic fields have evolved in recent years, resulting…

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Could protein engineers have built the next billion pound pharma company?

Peptone is using science to build the world’s first protein engineering operating system, combining AI with computational molecular physics. Above, a 3D illustration of proteins. Photo: Getty Life comes at you fast. At one point Peptone, a computational biophysics company, had been rejected by more than 150 investors. Now, it…

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New research provides an additional overview of optimistic reasons related to heart regeneration

CRISPR / Cas9 Wls knockdown in cardiomyocytes promotes cardiac fibroblast proliferation during neonatal cardiac regeneration. Green indicates vimentin-positive cardiac fibroblasts. Red indicates cells that are proliferating with the EdU label. Blue indicates nuclei with DAPI staining. Credit: Texas Heart Institute Texas Heart Institute has new research from its abundant cardiomyocyte…

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Invitae hiring Bioinformatics Engineer Lead in Irvine, California, United States

Invitae is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. Our team is driven to make a difference for the patients we serve. We are leading the transformation of the genetics industry, by making clinical-grade genetic information affordable and accessible to guide…

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Senior Bioinformatics Data Scientist – Invitae

Location: San Francisco, CA or Remote in USA Invitae is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people! Our team is driven to make a difference for the patients we serve. We are leading the transformation of the genetics industry by making…

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Bioinformatics Analyst at Invitae

  Invitae is dedicated to bringing comprehensive genetic information into mainstream medicine in order to improve healthcare for billions of people. The Clinical Informatics team is driven to make a difference for the patients we serve. We are leading the transformation of the genetics industry by making clinical-grade genetic information…

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