Tag: FAIR

New strategy for safer CAR T cell therapy in lymphomas

Graphical Abstract. Credit: Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101421 In treating aggressive lymphomas and blood cancer (leukemia), chimeric antigen receptor T cells (CAR T cells) are increasingly being used. For this therapy, immune cells are taken from patients and programmed by means of genetic engineering to detect proteins in the…

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Gritstone bio hiring SENIOR BIOINFORMATICS ENGINEER in Boston, MA

DescriptionGritstone bio is a public, next-generation personalized cancer and infectious immunotherapy company. Gritstone brings together distinguished scientific founders, an experienced and diverse management team, a seasoned and successful board of directors and deep financial backing to tackle fundamental challenges at the intersection of cancer genomics, immunology, and immunotherapy design. The…

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Galaxy Newsletter: December 2023 – Galaxy Community Hub

Hello, Galaxy Community! Firstly, the Galaxy team would like to extend our warmest wishes to you and all your loved ones this holiday season! With the New Year rapidly approaching, we wanted to thank you all for being a part of the Galaxy Community in 2023; we couldn’t do it…

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MAVS found to antagonize human stem cell senescence as a mitochondrial stabilizer

MAVS maintains mitochondrial homeostasis and regulates cellular senescence through stabilizing OPA1. A. Depletion of MAVS accelerates cellular senescence of human mesenchymal stem cells. B. MAVS deficiency compromises mitochondrial dynamics. C. A model illustrating the MAVS-OPA1 axis regulates mitochondrial homeostasis and human stem cell senescence. Credit: Research A recent study led…

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Research reveals man born thousands of miles to the east traveled to Cambridgeshire 2,000 years ago

Archaeologists excavate the Offord Cluny 203645 burial. Credit: MOLA Headland Infrastructure Scientists from the Francis Crick Institute, Durham University, and MOLA Headland Infrastructure have discovered that a man who lived between AD 126–228 during the Roman period did not originally come from a rural farmstead near where he was buried,…

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MedinCell Publishes Its Consolidated Half-year Financial Results

MONTPELLIER, France–(BUSINESS WIRE)–Regulatory News: MedinCell (Paris:MEDCL): Commercial launch by Teva of UZEDY™, the first product based on BEPO® technology, in the United States, and collect of first royalties representing €635K (June-September 2023). Christophe Douat, CEO of MedinCell, said: “Commercial revenues will transform MedinCell for the long term, especially as the…

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Scientists discover novel way to attack the trypanosome parasite through its ribosome

Localization of developmentally regulated Ψ sites on the trypanosomatid ribosome. Differentially regulated Ψ sites in T. brucei total rRNA are shown on the 3D structure of the ribosome. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-43263-6 Trypanosome is a single-celled parasite that takes an extensive human and economic toll due to its…

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Large companies are looking for ways to ensure the ethical and legal development of artificial intelligence

Carme Artigas, Secretary of State for Digitalization and Artificial Intelligence, and Commissioner Thierry Breton (in the foreground), on December 9 after the agreement on the European artificial intelligence law.SIERAKOWSKI FREDERIC Europe has taken a step forward with the approval of the world’s first regulation to regulate artificial intelligence. This categorizes…

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Newly discovered hedgehog species diverged from others more than a million years ago

A living Mesechinus orientalis sp. nov. (XC 2205003) from Xuancheng, Anhui. Credit: ZooKeys (2023). DOI: 10.3897/zookeys.1185.111615 Researchers at Anhui Normal University, Wuhu, China, have announced the discovery of a new species within the hedgehog genus Mesechinus. The eastern China hedgehog species was found to be distinct from other regional hedgehogs…

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Old convertible cars for sale near me

Catalytic converters are an important part of a car’s emission system, and they can be recycled for scrap metal. Selling catalytic converter scrap can be a lucrative business, but there are a few things to consider in order to maximize prof…1968 Oldsmobile 442 Beautiful Vintage Convertible! 75,894km Specs: Engine Size…

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Genetics of host plants determine what microorganisms they attract, finds study

Miscanthus species are bioenergy crops because they require lower nutrient concentrations to achieve more growth. Credit: L. Brian Stauffer Plants often develop communities with microorganisms in their roots, which influences plant health and development. Although the recruitment of these microbes is dictated by several factors, it is unclear whether the…

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New study challenges belief that opioids are effective at treating cancer pain

Effect of geographic ancestry on CYP2D6 genotype. CYP2D6 indicates cytochrome P450 2D6. Adapted from information in Table 1 of Gaedigk et al., 2017. Credit: CA: A Cancer Journal for Clinicians (2023). DOI: 10.3322/caac.21823 The world’s largest review on opioid medicines for cancer pain has found it is unclear whether some commonly used…

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‘X-ray vision’ for investigation of mRNA nanomedicines

EMBL Staff Scientist Melissa Graewert together with two users from the Johannes Gutenberg University Mainz are performing measurements of RNA using small-angle X-ray scattering at the EMBL beamline P12 in Hamburg. Credit: Dorota Badowska/EMBL A new technology co-developed at EMBL Hamburg provides new insights into mRNA pharmaceuticals and other nanomedicines,…

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First steps in version control with GitHub

Description Convenor: Alexia Cardona (CDH RSE Methods Fellow) Please note this workshop has limited spaces and an application process in place. Application forms should be completed by noon, Friday 16 February 2024. Successful applicants will be notified by the end-of-day Wednesday 21 February 2024. Version control helps you to write…

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A prospective study clarifies the role of an innovative metagenomic tool

Characteristics of samples analyzed by mNGS(A) Distribution of sample types among the 742 samples analyzed by mNGS in the present study. (B) Distribution of the sample origins in the tissue category. (C) Distribution of the sample origins in the fluid category. CSF=cerebrospinal fluid. FFPE=formalin-fixed paraffin-embedded. BMA=bone marrow aspiration. URT=upper respiratory…

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Insights from the Global Wheat Challenge on deep learning and dataset diversity

Sample from the UQ Frame dataset. Credit: Plant Phenomics Crowdsourcing has become pivotal in scientific research, particularly in data-intensive fields like plant phenotyping, leveraging platforms like Kaggle for data analysis and machine learning challenges. While effective in controlled environments, the robustness and generalizability of deep learning methods in plant phenotyping,…

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Alteryx to be acquired by private equity firms for $4.4 billion

Alteryx on Monday reached an agreement to be acquired by private equity firms Clearlake Capital Group and Insight Partners for $4.4 billion. Under the terms of the agreement, Alteryx’s stockholders will receive $48.25 per share upon closing, which remains subject to customary closing conditions and approvals and is expected…

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Horizon scan identifies 15 most pressing issues for conservation, including invertebrate decline and marine ecosystems

A step-by-step guide to how the researchers developed the list of 15 issues. Credit: Current Biology, Sutherland et al. Since 2009, the Cambridge Conservation Initiative has coordinated an annual horizon scan, a well-established method for predicting which threats, changes, and technologies will have the biggest impact on biological conservation in…

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New updates on the use of Shapley value part3(Machine Learning Fall’23) | by Monodeep Mukherjee | Dec, 2023

Getting started with Shapely Values ONNXExplainer: an ONNX Based Generic Framework to Explain Neural Networks Using Shapley Values(arXiv) Author : Yong Zhao, Runxin He, Nicholas Kersting, Can Liu, Shubham Agrawal, Chiranjeet Chetia, Yu Gu Abstract : Understanding why a neural network model makes certain decisions can be as important as…

Continue Reading New updates on the use of Shapley value part3(Machine Learning Fall’23) | by Monodeep Mukherjee | Dec, 2023

Using Google Cloud Vertex AI Code Chat to automate programming test scoring | by Cyrus Wong | Google Developer Experts | Dec, 2023

Traditionally, educators create unit tests to automatically score students’ programming tasks. However, the precondition for running unit tests is that the project codes must be runnable or compiled without errors. Therefore, if students cannot keep the project fully runnable, they will only receive a zero mark. This is undesirable, especially…

Continue Reading Using Google Cloud Vertex AI Code Chat to automate programming test scoring | by Cyrus Wong | Google Developer Experts | Dec, 2023

Helen Flanagan shows off her figure in a white mini skirt and black fur-trim top as she poses for sizzling snaps (and her engagement ring is STILL on)

Helen Flanagan looked stunning as she posed for a slew of racy Instagram pictures on Sunday. The former Coronation Street star, 33, displayed her toned physique in sizzling mirror selfies, which also clearly showed her engagement ring from ex-fiancé Scott Sinclair. Helen and the Bristol Rovers footballer split in July 2022 after 13…

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Retired FBI Agent Warns Why You Shouldn’t Get 23andMe DNA Kit

Have you or anyone in your family considered using DNA testing services of companies like 23andMe or Ancestry.com? One former FBI agent is warning against the use of such websites, citing privacy as a concern. In a TikTok video, retired FBI agent Steve Lazarus (@steve.lazarus.books) speaks about the potential risks…

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Meta Embraces Open Source Approach to AI Development

Meta, the company that owns Facebook and Instagram, is taking a stand against the trend of keeping artificial intelligence (AI) technology closely guarded. Unlike other major tech companies, Meta is committed to publishing and sharing their AI research, promoting an open-source approach. This move aims to prevent a concentration of…

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Budget ’24: Hiring two employees to trim trees will add 0.4% to municipal tax hike

It takes city hall roughly 30 years to complete one full pruning cycle of the community’s roughly 15,000 trees, but city council hopes extra employees can help improve overall forest management. It takes city hall roughly 30 years to complete one full pruning cycle of the community’s roughly 15,000 trees,…

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Google shapes up Gemini AI tool for developers

Google MedLM is a family of foundation models designed for the healthcare industry at Google , [+] Cloud. Google Artificial Intelligence (AI) is changing. But let’s not forget where we came from. Early notions of pseudo-sentient intelligence emerging from the mainframe laboratories of the 1950s may have been too embryonic…

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The Future of Extra-Large Foundational Models in AI | by Girish Babu (Entrepreneur, Advisor, Exec, MBA) | Dec, 2023

Image by Freepik In the ever-evolving Artificial Intelligence (AI) space, the dawn of extra-large foundational models has ushered in a new era of possibilities. These models, characterized by their immense scale and complexity, have become a focal point in AI research and development. As we delve into the future, we…

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Google Shapes Gemini AI Tools For Developers

Google MedLM is a family of foundation models fine-tuned for the healthcare industry on Google … [+] Cloud. Google Artificial Intelligence (AI) is changing. But let’s not forget where we’ve come from. The early notions of pseudo-sentient intelligence that percolated out of the mainframe labs of the 1950s may have…

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Transformative Synergy: Unleashing the Power of Large Language Models with Google Vertex AI | by Sahibdeep Singh Sodhi | Dec, 2023

Introduction: In the ever-evolving realm of artificial intelligence, the fusion of cutting-edge technologies has paved the way for unprecedented advancements. Google’s Vertex AI, a comprehensive machine learning platform, has emerged as a game-changer, particularly in enhancing the capabilities of large language models. In this blog, we’ll delve into the transformative…

Continue Reading Transformative Synergy: Unleashing the Power of Large Language Models with Google Vertex AI | by Sahibdeep Singh Sodhi | Dec, 2023

A CRISPR pioneer looks back as the first gene-editing therapy is approved

Credit: Pixabay/CC0 Public Domain In 2007, Luciano Marraffini struck out on what was then a scientifically lonely path: to understand CRISPR, which had been discovered in bacteria only about a decade before. Seventeen years later, we all know what CRISPR is: a revolution in medicine; a once-in-a-lifetime scientific breakthrough; the…

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Top 7 Best Fat Burners South Africa

Women have different fat storage patterns than men, so it makes sense that a woman should choose a female fat burner, a supplement that is made for a woman’s fat loss needs. This article gives you information about the 5 best fat burning supplements for women that you can buy…

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Google Vertex AI: Your AI Powerhouse For Every Business Need

In a recent article, I explained why I left the agency business behind and accepted a CMO position at a retail AI platform, OpenINSIGHTS. In full disclosure, the company is a Google partner and has designed and engineered a platform in the retail DTC industry that’s exceeding everyone’s expectations… especially…

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Researchers discover first-ever link between hemoglobin-like protein and normal heart development

cygb2 mutant phenotype presents organ laterality defects. a CRISPR/Cas9 mediated genome editing of cygb2. Two different gRNA were targeted to exon 1 (denoted by red text) and resulted in 4 bp and 1 bp frame shift mutations (beginning in the blue shaded region of the predicted protein structure) named cygb2801a and cygb2801b,…

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Ribosomal protein exhibits remarkable evolutionary transformation

The cryo-EM maps and atomic models showing the structure of ribosomal protein msL1 in the ribosome from microsporidian parasites V. necatrix (first row), and protein msL2 in the ribosome from microsporidian parasites E. cuniculi (second row). Credit: Leon Schierholz/Umea University A team of researchers from the Universities of Newcastle and…

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Editas (EDIT) Licenses Cas9 Tool to Vertex, Stock Up 6%

Editas Medicine, Inc. EDIT announced entering into a licensing agreement with Vertex Pharmaceuticals VRTX for the development of the latter’s new sickle cell disease (SCD) gene therapy, Casgevy. Per the terms of the agreement, Vertex will receive a non-exclusive license to utilize Editas’ Cas9 gene editing technology for ex vivo gene editing medicines…

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Biopharma Company Issues New Patent Application; Phase 3 Clinical Trials for Cancer Treatments: RenovoRx (NASDAQ: RNXT)

RenovoRx, Inc. Nasdaq: RNXT NASDAQ: RNXT $RNXT Clinical Sites RenovoTAMP $RNXT Battles Cancer Tumors Direct! RenovoTAMP $RNXT Advancing Cancer Treatments: RenovoRx’s Phase 3 Clinical Trials in Partnership with Imugene RenovoRx, Inc. (NASDAQ:RNXT) LOS ANGELES , CALIFORNIA , UNITED STATES , December 14, 2023 /EINPresswire.com/ — Biopharma Company Issues New Patent…

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Sault Innovation Centre may need to trim budget, grow revenue quicker

Breadcrumb Trail Links Politics News Local News City council cut $277,890 from the levy — effectively giving notice to the SSMIC that they’re annual funding may not exist after 2024. Author of the article: Elaine Della-Mattia Published Dec 14, 2023  •  Last updated 2 hours ago  •  4 minute read The…

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Google Gemini just got one step closer to a public debut

Summary Gemini Pro, Google’s new AI model, is set to revolutionize the company’s operations and assert dominance in the AI game. Developers can now experiment with Gemini Pro through Vertex AI, Google’s unified AI platform, using the Gemini Pro API. Gemini Pro currently supports 38 languages and regions, offers features…

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Lead Architect Bioinformatics Job in Berkshire, Other Career, Permanent Jobs in Syngenta Group

Company Description Syngenta is a leading science-based Ag-tech company dedicated to bringing plant potential to life. Each of our 28,000 employees in more than 90 countries works together to solve one of humanity’s most pressing challenges: growing more food with fewer resources. From the moment a seed is planted…

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How To Install slurm-doc on Rocky Linux 8

In this tutorial we learn how to install slurm-doc on Rocky Linux 8. slurm-doc is Slurm documentation Introduction In this tutorial we learn how to install slurm-doc on Rocky Linux 8. What is slurm-doc Documentation package for Slurm. Includes documentation and html-based configuration tools for Slurm. We can use yum…

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Your Gateway to Gemini’s Creative Universe!

Google has introduced a game-changer for developers with the launch of AI Studio, a web-based platform aimed at providing seamless access to its Gemini AI models. This innovation is poised to revolutionize the development and deployment of chatbots, applications, and various software, leveraging the advanced natural language generation capabilities of…

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New method tags cells with location coordinates for single-cell studies

Brain cells (each represented by a dot), categorized into seven cell types (each a different color), are spatially mapped in a 10 mm square region of the human prefrontal cortex. Credit: Russell AJC et al., Nature 2023, doi:10.1038/s41586-023-06837-4 When a scientist wants to study individual cells at the molecular level…

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University Assistant Predoctoral, Life Sciences job with UNIVERSITY OF VIENNA

50 Faculty of Life Sciences Startdate: 01.01.2024 | Working hours: 30 | Collective bargaining agreement: §48 VwGr. B1 Grundstufe (praedoc) Limited until: 31.12.2026 Reference no.: 1758 Among the many good reasons to want to research and teach at the University of Vienna, there is one in particular, which has convinced around 7,500 academic staff members so far. They see…

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Scientist (Postdoc) in the field of Bioinformatics/Artificial Intelligence, Leipzig, Sachsen

The Fraunhofer-Gesellschaft () currently operates 76 institutes and research institutions throughout Germany and is the world’s leading applied research organization. Around employees work with an annual research budget of 2.9 billion euros. Its Fraunhofer Institute for Cell Therapy and Immunology IZI researches and develops special problem solutions at the interfaces…

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AI Training Dataset Market Growing Popularity & Emerging Trends| Google, Microsoft, Sparta Science

PRESS RELEASE Published December 13, 2023 The latest study released on the Global AI Training Dataset Market by HTF MI evaluates market size, trend, and forecast to 2029. The AI Training Dataset market study covers significant research data and proofs to be a handy resource document for managers, analysts, industry…

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An integrated individual-level trait-based phytoplankton dataset from transitional waters

McGill, B. J., Enquist, B. J., Weiher, E. & Westoby, M. Rebuilding community ecology from functional traits. Trends Ecol. Evol. 21, 178–185 (2006). Article  PubMed  Google Scholar  Diaz, S. et al. The global spectrum of plant form and function: enhanced species-level trait dataset. Sci. Data 9, 755 (2022). Article  PubMed …

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gpu – slurm – dynamic allocation

Thanks for reading this question I am interested in implementing a dynamic and fair distribution of GPUs based on current usage situations. For instance, in a server with 12 GPUs and 3 users, I would initially allocate 4 GPUs to each user fairly. As the situation changes, if one user…

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Correlation methods giving very different results (WGCNA)

Hi all, I’ve come back to WGCNA after some years and have run into a bit of a quirky result when looking at my soft power thresholds depending correlation the methods I use. Generally, this topic has been discussed a fair bit – but was looking to see if anyone…

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Ukraine has lost almost 20% of its scientists due to the war, study finds

Credit: Pixabay/CC0 Public Domain Until the early morning of February 24, 2022, Ukrainian scientist Olena Iarmosh did not believe there would be a Russian invasion of Ukraine. Iarmosh grew up and had settled in Kharkiv, her beloved city in Eastern Ukraine and only 40 km away from the Russian border,…

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A Majority of Subjects in Jaguar Health s Placebo-Controlled Pivotal Phase 3 OnTarget Trial for Prophylaxis of Diarrhea in Adult Cancer Patients Receiving Targeted Therapy Chose to Continue on to Stage II -December 12, 2023 at 06:22 am EST

SAN FRANCISCO – Napo Pharmaceuticals (Napo), a Jaguar Health, Inc. (NASDAQ: JAGX) (Jaguar) family company, today announced that a majority of subjects in the company s placebo-controlled pivotal Phase 3 OnTarget trial for prophylaxis (prevention) of diarrhea in adult cancer patients receiving targeted therapy with or without standard chemotherapy chose…

Continue Reading A Majority of Subjects in Jaguar Health s Placebo-Controlled Pivotal Phase 3 OnTarget Trial for Prophylaxis of Diarrhea in Adult Cancer Patients Receiving Targeted Therapy Chose to Continue on to Stage II -December 12, 2023 at 06:22 am EST

Biopharma Company Reaches Phase 3 Clinical Trials for Cancer Treatments; 9 Patents Issued; Collaboration with Imugene: RenovoRx (NASDAQ: RNXT)

PRESS RELEASE Published December 12, 2023 Clinical-Stage Biopharma Company Developing Proprietary Targeted Combination Therapies for High Unmet Medical Needs in Oncology.   Trans-Arterial Micro-Perfusion (TAMPTM) Therapy Designed to Directly Target Tumors While Potentially Minimizing Toxicities.  Welcomed Ducreux, M.D., Ph.D., Head of the Gastrointestinal Oncology Unit and Gastrointestinal Oncology Tumor Board at…

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New comprehensive genome data on soil invertebrates provide insights into their biodiversity

The MetaInvert project provides comprehensive genomic data on tiny and previously little-studied soil organisms such as springtails (here the species Neelus murinus). Credit: Andy Murray With the “MetaInvert” project, scientists are providing extensive genomic data on 232 species of previously little-studied organisms. They are tiny, enormously diverse, and widespread in…

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Biopharma Company Reaches Phase 3 For Cancer Treatments 9 Patents Collaboration With Imugene: Renovorx NASDAQ: RNXT

(MENAFN– EIN Presswire) RenovoRx, Inc. Nasdaq: RNXT NASDAQ: RNXT $RNXT Clinical Sites RenovoTAMP $RNXT Battles Cancer Tumors Direct! RenovoTAMP $RNXT $RXNT is a Clinical-Stage Biopharma Company Developing Proprietary Targeted Combination Therapies for High Unmet Medical Needs in Oncology. RenovoRx, Inc. (NASDAQ: RNXT) LOS ALTOS, CALIFORNIA, UNITED STATES, December 12, 2023…

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Biopharma Company Reaches Phase 3 for Cancer Treatments; 9 Patents; Collaboration with Imugene: RenovoRx NASDAQ: RNXT

RenovoRx, Inc. Nasdaq: RNXT NASDAQ: RNXT $RNXT Clinical Sites RenovoTAMP $RNXT Battles Cancer Tumors Direct! RenovoTAMP $RNXT $RXNT is a Clinical-Stage Biopharma Company Developing Proprietary Targeted Combination Therapies for High Unmet Medical Needs in Oncology. RenovoRx, Inc. (NASDAQ: RNXT) LOS ALTOS, CALIFORNIA, UNITED STATES, December 12, 2023 /EINPresswire.com/ — Biopharma…

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Collaborative study shows CAR-T cell therapy safe, effective even for high-risk patients

Credit: Pixabay/CC0 Public Domain CAR-T cell therapy is a safe and effective treatment for diffuse large B-cell lymphoma (DLBCL), even for patients regarded as high risk due to comorbidities. That’s the conclusion of a five-year analysis of results from the U.S. Lymphoma CAR-T Cell Consortium, a group of 17 academic…

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Bluebird Bio gets gene therapy approval but no business boost

The dual approvals have linked the two drugs, inviting comparisons while positioning the gene-editing drug, called Casgevy, to come out on top, analysts said. Casgevy, developed by Boston-based Vertex Pharmaceuticals and its Swiss partner CRISPR Therapeutics, costs nearly $1 million less than Lyfgenia and has a better safety profile. Bluebird,…

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Carol Kirkwood ‘so trim’ in blue dress as BBC Breakfast co-stars announce shock absence

THERE was nothing blue about Carol Kirkwood’s appearance today as she stunned in a gorgeous navy dress. The BBC Breakfast legend, 61, was on hand with the weather as two of her co-stars announced their absence from the show. 1 BBC Breakfast host Carol Kirkwood looked stunning in a low-cut…

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Google’s New AI, Gemini, Beats ChatGPT In 30 Of 32 Test Categories

Better performance than ChatGPT? © 2023 Bloomberg Finance LP Google has released a new Pro model of its latest AI, Gemini, and company sources say it has outperformed GPT-3.5 (the free version of ChatGPT) in widespread testing. According to performance reports, Gemini Ultra exceeds current state-of-the-art results on 30 of…

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24 OpenAPI Interview Questions and Answers

Introduction: Welcome to our comprehensive guide on OpenAPI interview questions and answers! Whether you’re an experienced developer looking to brush up on your skills or a fresher entering the exciting world of API development, this resource is designed to help you navigate common questions that may arise during an OpenAPI…

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Genomic profiling offers early clues to stomach cancer development

Graphical abstract. Credit: Cancer Cell (2023). DOI: 10.1016/j.ccell.2023.10.004 In a breakthrough study published in Cancer Cell, researchers have decoded critical genetic factors in intestinal metaplasia patients, shedding light on early signs and prevention strategies for stomach cancer—often a “ticking time bomb” as patients experience no or only mild symptoms in…

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Syngenta hiring Lead Architect Bioinformatics in Bracknell, England, United Kingdom

Company DescriptionSyngenta is a leading science-based Ag-tech company dedicated to bringing plant potential to life. Each of our 28,000 employees in more than 90 countries works together to solve one of humanity’s most pressing challenges: growing more food with fewer resources. From the moment a seed is planted through to…

Continue Reading Syngenta hiring Lead Architect Bioinformatics in Bracknell, England, United Kingdom

2022 Hyundai Ioniq 5: Every Trim Compared

The Hyundai Ioniq 5 is the South Korean brand’s premier electric crossover, which launched the all-electric Ioniq portfolio in the U.S. The mid-size SUV in electric cars neatly balances futuristic aesthetics with contemporary design cues. It creates a unique-looking product that stays close to conventional car designs. TOPSPEED VIDEO OF…

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The emergence of CRISPR-Cas engineered strains

CRISPR-based genome editing in probiotics. Credit: BioDesign Research Probiotics, defined as live microorganisms beneficial to health, have shown promise in areas like anti-inflammatory activity and brain function, etc. However, challenges remain due to variability in tolerance and colonization among species and strains. Recent advances in genome engineering, including CRISPR-Cas, have…

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Where To Find Datasets For Machine Learning

Government Websites Government websites are excellent sources of datasets for machine learning projects. Many government organizations collect a vast amount of data covering a wide range of subjects, from demographics to climate change. These datasets are often comprehensive, reliable, and freely accessible, making them valuable resources for researchers, analysts, and…

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New personalized therapy improves survival for patients with CLL leukemia, phase 3 trial finds

Credit: Pixabay/CC0 Public Domain Personalized treatment for the most common form of adult leukemia helps patients survive for longer and stay in remission, a phase 3 trial has found. The trial, by the University of Leeds, is published in the New England Journal of Medicine and has been presented at…

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What Is Pytorch And Why Should You Use It? | by Nilesh Parashar | Dec, 2023

PyTorch has emerged as a prominent framework, enabling data scientists and engineers to create sophisticated machine learning models and tackle complex tasks. In this article, we’ll delve into what PyTorch is, its functions, and why you should consider using it as a valuable tool in your AI and machine learning…

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Between 3.51 Crores to 4 Crores Properties for Sale in Phase 3, Delhi – NoBroker

Filters Premium FiltersNew BHK Type 1 RK 1 BHK 2 BHK 3 BHK 4 BHK 4+ BHK Price Range: ₹ 0 to ₹ 10 Cr Showing properties near your searched localities Didn’t find what you are looking for? Explore nearby localities or Post Your Requirement and we will send an…

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Colorado PUC considers trim of Xcel plan to build new solar, wind

Faced with the largest plan for new electricity generation and transmission in the state’s history, the Colorado Public Utilities Commission on Wednesday expressed concerns about the scale and timing of the Xcel Energy proposal. PUC Chairman Eric Blank, while stressing deliberations are just beginning on the $15 billion plan, suggested…

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FDA approves the first gene-editing treatment in the US

Today, the United States Food and Drug Administration (FDA) approved a historic treatment for sickle cell disease. Casgevy is the first medicine based on CRISPR gene-editing technology. The procedure was approved for use in the United Kingdom in November.  [Related: The UK becomes the first country to approve CRISPR treatment.]…

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Antibiotic resistance genes are spread more widely between bacteria than previously thought

Plasmid transfer from the Escherichia coli MG1655 donor strain to bacterial community extracted from a hospital wastewater treatment plant. (A) Transconjugants formed in the absence of NaClO. The green fluorescence indicates successful acquisition of the gfp-expressing plasmid. (B) Transconjugants formed in the presence of 40 mg/L NaClO. (C) Transconjugants formed…

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Criteria for better assessment of rare genetic variants that can lead to hereditary colorectal cancer

APC gene, APC protein, and criteria boundaries and genotype-phenotype correlations. Representation of the APC gene (bottom) and its main protein product (middle) on the reference sequence NM_000038.6 (non-coding exon 1 not shown). The figure shows on the top the boundaries for the application of PVS1, BS3 and BP1 and genotype-phenotype…

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Experimental HIV vaccine regimens likely to be ineffective in preventing HIV acquisition, research finds

The first PrEPVacc volunteer participant receives an injection at the launch of the launch of the PrePVacc Trial at the Masaka site of the MRC/UVRI and LSHTM Uganda Research Unit, on Tuesday 15 December 2020. Credit: PrEPVacc Investigators The PrEPVacc HIV prevention study of experimental vaccine regimens and a new…

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Researchers investigate how climate change drivers reshape ocean methane and nitrous oxide cycles

Credit: Pixabay/CC0 Public Domain The ocean is a critical life-support system for our planet through its role in global climate regulation. It absorbs most of the carbon emissions and heat trapped in the atmosphere, which result from human activities. Over the years, this has led to ocean warming (OW), ocean…

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Haley Says TikTok Makes Viewers More Antisemitic

CLAIM: Nikki Haley says TikTok makes those who consume it more likely to hold antisemitic views than they were before. VERDICT: PARTLY TRUE. There is one recent survey to back that up, though there are questions about its methodology. Former UN Ambassador and South Carolina governor Haley called for a…

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What Is PyTorch And How Does It Operate?

PyTorch is an open-source machine learning (ML) framework based on the Python programming language coupled with the Torch library. Launched in 2016 by Facebook AI Research (now AI Research at Meta Platforms Inc), PyTorch has become one of the most popular machine-learning libraries among professionals and researchers. How does…

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New ‘dictionary’ of immune responses reveals far more complexity in the immune system than previously thought

Cytokine production map by cell type. Credit: Nature (2023). DOI: 10.1038/s41586-023-06816-9 The immune system can carry out many biological processes, from killing viruses to fighting cancer, thanks in large part to approximately 100 key cell-signaling proteins called cytokines, which instruct immune cells what to do. Cytokines are also targeted by…

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Bio Europe 2023: the highlights

The biopharma community met at Munich in Germany for BIO-Europe 2023, where attendees from across the world took part in networking events to foster collaboration, last month. With a turnout of nearly 6000 participants and more than 150 exhibitors, the event hosted a number of panel discussions. In collaboration with…

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Curb Launches Open API That Aggregates Ride-Hailing Demand

Curb, a taxi solutions and ride-hailing app, has unveiled an open application programming interface (API) that aggregates ride demand from various sources.  The new Curb Flow API aims to revolutionize the ride-hailing industry by enhancing drivers’ income opportunities and streamlining the driver experience, the company said in a Wednesday (Dec….

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Map of disease-causing mutations in neurodevelopmental disorders and cancer revealed

Experimental design overview. a Two independent sgRNAs and associated HDR variant libraries are designed at the 5′ and 3′ end of each exon. b The sgRNA, together with the HDR template library are transfected into LIG4-KO Cas9-expressing HAP1 cells. HDR utilizes the library as a template for repair of the…

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Scientists develop ‘sexy_markers,’ a bioinformatics tool that reveals white shark gender

Great white shark at Isla Guadalupe, Mexico, August 2006. Credit: Terry Goss/Wikipedia A new study led by CSIRO, Australia’s national science agency, has revealed white shark gender is determined by X and Y sex chromosomes. The researchers developed a robust method to find sex chromosomes in a shark’s genome and…

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Google’s Gemini: A Closer Look at the Next-Gen AI Model

Google’s highly anticipated generative AI model, Gemini, has finally made its debut. However, it’s not quite the revolutionary model we were expecting. During a virtual press briefing, members of the Google DeepMind team unveiled Gemini 1.0, which is actually a family of AI models rather than a single model. Let’s…

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Ice cores as a source for antimicrobials: From bioprospecting to biodesign

Credit: Unsplash/CC0 Public Domain In November 2023, BioDesign Research published a perspective article titled “Ice Cores as a Source for Antimicrobials: From Bioprospecting to Biodesign,” outlining a revolutionary approach to antibiotic discovery using ice cores. This innovative article comes at a pivotal time, as the golden age of antibiotic discovery…

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BF23 bacteriophage study reveals that viruses can cope with bacterial restriction and modification

Model of BF23 virion with depicted positions of proteins identified by mass spectrometry analysis of phage virion. Credit: Mikhail Skutel and coauthors Bacteriophages are natural “predators” and enemies of bacteria. They are able to recognize specific types of bacteria and are considered safe for humans. Due to the increasing resistance…

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Deep Learning With PyTorch (Audiobook) | Santa Clara County Library

With this publication, we finally have a definitive treatise on PyTorch. It covers the basics and abstractions in great detail. From the Foreword by Soumith Chintala, Cocreator of PyTorch Every other day we hear about new ways to put deep learning to good use: improved medical imaging, accurate credit card…

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Bioinformatics Analyst in Proteomics – basel-jobs.ch

The Position In Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity,…

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Faith Meets Byte: Unraveling the Holy Code of Blockchain and Scriptures | by Cindrum Official | Dec, 2023

Throughout the time, religion and science have choreographed a dance of discord, from the historic Galileo to contemporary debates on evolution and cosmic creation. This dance revolves around the perceived threat scientific discoveries pose to sacred scripts, challenging religious doctrines entrenched in the binary code of belief. In this techno-theological…

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New enzyme allows CRISPR technologies to accurately target almost all human genes

Credit: Nature Chemical Biology (2023). DOI: 10.1038/s41589-023-01481-5 A team of engineers at Duke University have developed a method to broaden the reach of CRISPR technologies. While the original CRISPR system could only target 12.5% of the human genome, the new method expands access to nearly every gene to potentially target…

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What Is PyTorch and How Does It Work?

The guide below is devoted to PyTorch – an open-source machine learning (ML) framework based on the Python programming language and the Torch library. We will explore how it works, discuss its key features, the problems it addresses, and the benefits it provides. Launched in 2016 by Facebook AI Research…

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COVID Native research, CRISPR for sickle cell

Understand how science, health policy, and medicine shape the world everyday. Sign up for our Morning Rounds newsletter here. How sickle cell became the first CRISPR’d disease Nearly a decade ago, consultants delivered to Rodger Novak a kind of Sears catalog of human malady: 200 pages, listing dozens of different…

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what do you think of it in the next 20 years?

Bioinformatics: what do you think of it in the next 20 years? 1 Is Bioinformatics a really great field, what do you think of it in the next 20 years? question Bioinformatics • 426 views I think there will be more data and code management with the development of FAIR…

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Investigating needle-free ultrasound vaccine delivery

Ultrasound pulses deliver vaccines through the skin without needles. This technique, which employs sound waves to create bubbles that forge a path for the vaccine, may be especially helpful for DNA vaccines. Credit: Darcy Dunn-Lawless An estimated quarter of adults and two-thirds of children have strong fears around needles, according…

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Remote Bioinformatics Analyst II – Remote | WFH in United States

We are a dynamic and collaborative international bioinformatics team dedicated to advancing Neuroscience research. Our focus lies in harmonizing internal OMICS data sets, ensuring effective data storage according to FAIR data principles (Findable, Accessible, Interoperable, and Reusable), and broadening our knowledge base for future integrative analyses. ** Project Objective And…

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Scientists create ‘cloaked’ donor cell and tissue grafts that escape rejection by the immune system

a, Candidate immunomodulatory factors and their roles in the innate and adaptive immune pathways involved in rejection of non-self. The underlined factors were selected to generate transgene-containing vectors. b, Schema showing the generation of clonal B6 mESCs that express the selected eight immunomodulatory transgenes via insertion with piggyBac (PB) and…

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‘Yuva Rojgar Manch’ organized by National Institute of Electronics & Information Technology, Guwahti

TEZPUR: National Institute of Electronics & Information Technology (NIELIT), Guwahti, under Ministry of Electronics & Information Technology, Government of India, in association with National Career Service Centre for SC/ST, Guwahati, Ministry of Labour & Employment, Government of India, and Edupur, Employment Services Pvt. Ltd. organized a Job Fair 2023 “Yuva…

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Developing more advanced renal organoids to model polycystic kidney disease

Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113431 A team of CiRA researchers, building upon their previous work on differentiating iPS cells into kidney organoids, have made significant improvements to build a better model of kidney development and diseases for use as a robust platform for drug discovery. Autosomal dominant polycystic kidney…

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Multi-domain and complex protein structure prediction using inter-domain interactions from deep learning

Overview of the method DeepAssembly is designed to automatically construct multi-domain protein or complex structure through inter-domain interactions from deep learning. Figure 1 shows an overview of the DeepAssembly protocol. Starting from the input sequence of multi-domain protein (or protein complex), DeepAssembly first generates multiple sequence alignments (MSAs) from genetic databases…

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History Says the S&P 500 Will Move Higher in December: 2 Magnificent Growth Stocks to Buy Before 2024 and Hold Long Term

The S&P 500 has already climbed roughly 19% this year amid soaring investor sentiment, but history says there is more gas in the tank. Since 1928, the index has frequently moved higher in December, more so than in any other month, returning an average of 1.3%. To be clear, I…

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Can science find a better way to trim a cat’s nails?

Animal Science Ph.D. student Jen Link works with a cat at the Sacramento SPCA on the best way to create a stress-free nail trimming experience for the animal and humans. Credit: Jael Mackendorf /UC Davis University of California, Davis, researchers are working with the Sacramento SPCA to alleviate a near-universal…

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The High Republic Phase 3 and The Nameless

The third phase of The High Republic stepped up a gear with the arrival of George Mann’s novel The Eye of Darkness, and StarWars.com take a closer look at the biggest threat to the Jedi since the arrival of the Nihil, The Nameless, a foe the Jedi know little about…

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DNA sequencing reveals clonal evolution of tumor in childhood leukemia

Immunophenotypic characteristics of sAML blasts in Patients 1. Plots demonstrating coexpression of CD2 and CD7 on sAML blasts. Credit: npj Systems Biology and Applications (2023). DOI: 10.1038/s41540-023-00303-7 Researchers at the RUDN Laboratory of Biology of Single Cells have studied the possibilities of DNA sequencing at the level of individual cells…

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Researchers study the link between the bacteria H. pylori and stomach cancer

NOD1 maintains epithelial homoeostasis in response to H. pylori infection. a, b Human AGS gastric epithelial cells stably expressing shRNA to either EGFP (shEGFP) or NOD1 (shNOD1) were stimulated with H. pylori (HP) 251 or left untreated (UT). c Confocal microscopy images of Nod1+/+ and Nod1−/− organoids showing E-cadherin+ epithelial…

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