Tag: FBXW7

Dihydroquercetin (DHQ) ameliorates LPS-induced acute lung injury by regulating macrophage M2 polarization through IRF4/miR-132-3p/FBXW7 axis

Background: Acute lung injury (ALI) is a common complication of sepsis. Dihydroquercetin (DHQ) has been found to attenuate lipopolysaccharide (LPS)-induced inflammation. However, the effect of DHQ on LPS-challenged ALI remains unclear. Methods: Pulmonary HE and TUNEL staining and lung wet/dry ratio were detected in LPS-treated Balb/c mice. IL-1β, IL-6 and…

Continue Reading Dihydroquercetin (DHQ) ameliorates LPS-induced acute lung injury by regulating macrophage M2 polarization through IRF4/miR-132-3p/FBXW7 axis

FBXW7 affects autophagy through MCL1 in oral squamous cell carcinoma

Background: Oral cancer is associated with high risk of morbidity and mortality. However, effective treatment for oral cancer is urgently required in clinics. In this study, we aimed to determine whether F-box/WD repeat-containing protein 7 (FBXW7), an essential tumor suppressor gene, can regulate autophagy and improve the prognosis in oral…

Continue Reading FBXW7 affects autophagy through MCL1 in oral squamous cell carcinoma

FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies

Review . 2023 Nov 13:14:1278056. doi: 10.3389/fphar.2023.1278056. eCollection 2023. Affiliations Expand Affiliation 1 Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China. Free PMC article Item in Clipboard Review Wanqing Wang et al. Front Pharmacol. 2023. Free PMC article Show details Display options Display options Format AbstractPubMedPMID . 2023…

Continue Reading FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies

FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe

FBXW7 is a commonly mutated tumor suppressor gene that functions to regulate numerous oncogenes involved in cell cycle regulation. Genome-wide CRISPR fitness screens identified a signature of DNA repair and DNA damage response genes as required for the growth of FBXW7-knockout cells. Guided by these findings, we show that FBXW7…

Continue Reading FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe

E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation

. 2023 Nov 26;80(12):374. doi: 10.1007/s00018-023-05019-9. Affiliations Expand Affiliations 1 School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram, Vithura, Thiruvananthapuram, Kerala, 695551, India. 2 School of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram, Vithura, Thiruvananthapuram, Kerala, 695551, India. tmanna@iisertvm.ac.in. Item in Clipboard Vishnu M Nair et…

Continue Reading E3-ubiquitin ligase, FBXW7 regulates mitotic progression by targeting BubR1 for ubiquitin-mediated degradation

Whole genome sequencing in high-grade cervical intraepitheli… : Medicine

1. Introduction Cervical cancer (CC) is the third most common cancer in women worldwide and has a high mortality rate among women. In 2008, CC was responsible for 275,000 deaths, thereby being the fourth leading cause of cancer death in females worldwide.[1,2] In China, CC is the second most…

Continue Reading Whole genome sequencing in high-grade cervical intraepitheli… : Medicine

Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice

Nonalcoholic steatohepatitis (NASH) is epidemiologically associated with obesity and diabetes and can lead to liver cirrhosis and hepatocellular carcinoma if left untreated. The intricate signaling pathways that orchestrate hepatocyte energy metabolism and cellular stress, intrahepatic cell crosstalk, as well as interplay between peripheral tissues remain elusive and are crucial for…

Continue Reading Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice

NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology

Patient characteristics and tissue context The clinical interpretation of molecular alterations starts with evaluating relevant patient characteristics and the tissue context in which a genetic profile occurs. The former relates, in particular, to previous therapies, in addition to disease stage and clinical performance status. For example, prior targeted therapies warrant…

Continue Reading NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology

Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

doi: 10.1002/1878-0261.13537. Online ahead of print. Joseph S Baxter  1   2 , Rachel Brough  1   2 , Dragomir B Krastev  1   2 , Feifei Song  1   2 , Sandhya Sridhar  1   2 , Aditi Gulati  2 , John Alexander  2 , Theodoros I Roumeliotis  3 , Zuza Kozik  3 , Jyoti S Choudhary  3…

Continue Reading Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Figure 5 | lncRNA DLX6-AS1 Promotes Myocardial Ischemia-Reperfusion Injury through Mediating the miR-204-5p/FBXW7 Axis

Mediators of Inflammation/ 2023/ Article/ Fig 5 / Research Article Figure 5 DLX6-AS1 promoted FBXW7 expression by sponging miR-204-5p. (a) The predicted binding sites between miR-204-5p and FBXW7 were presented. (b) The interaction between miR-204-5p and FBXW7 in H9c2 cells was verified by luciferase reporter assay. (c) H9c2 cells were…

Continue Reading Figure 5 | lncRNA DLX6-AS1 Promotes Myocardial Ischemia-Reperfusion Injury through Mediating the miR-204-5p/FBXW7 Axis

Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation | The Journal of Immunology

Address correspondence and reprint requests to Prof. Lihua Lai, Prof. Qingqing Wang, or Prof. Yong Xu, Sir Run Run Shaw Hospital, Department of Pharmacology, Zhejiang University School of Medicine, 866 Yu Hang Tang Road, Hangzhou 310058, China (L.L.), Institute of Immunology, Zhejiang University School of Medicine, 866 Yu Hang Tang…

Continue Reading Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation | The Journal of Immunology

Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation

doi: 10.4049/jimmunol.2300023. Online ahead of print. Yinjing Song  1 , Xiangtong Zhao  2 , Hao Qu  3 , Yixin Su  4 , Rukun He  4 , Luxia Chen  1 , Lutong Fang  2 , Jiaying Li  2 , Ziqi Zou  2 , Jia He  2 , Zilong Li  5   6 , Yaohan Xu  1 , Xin Chen  7 , Hao Cheng  1…

Continue Reading Epigenetic Regulation of IL-23 by E3 Ligase FBXW7 in Dendritic Cells Is Critical for Psoriasis-like Inflammation

Sci-Hub | FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease. Molecular Medicine, 25(1)

Sci-Hub | FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease. Molecular Medicine, 25(1) | 10.1186/s10020-019-0099-9 ◂ ↓ save Zhang, C., Chen, F., Feng, L., Shan, Q., Zheng, G.-H., Wang, Y.-J., … Zheng, Y.-L. (2019). FBXW7 suppresses…

Continue Reading Sci-Hub | FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease. Molecular Medicine, 25(1)

Porcine epidemic diarrhea virus antagonizes host antiviral response by downregulating the expression of FBXW7

The server is under maintenance between 08:00 to 12:00 (GMT+08:00), and please visit later. We apologize for any inconvenience caused Porcine epidemic diarrhea virus antagonizes host antiviral response by downregulating the expression of FBXW7 Author(s): LI Ming-wei, GUO Long-jun, SHI Zhao-rong, WU Yang, CHEN Jian-fei, SHI…

Continue Reading Porcine epidemic diarrhea virus antagonizes host antiviral response by downregulating the expression of FBXW7

The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development

FBXW7 is a critical regulator of cell cycle, cell signaling, and development. A highly conserved F-box protein and component of the SKP1-Cullin-F-box (SCF) complex, FBXW7 functions as a recognition subunit within a Cullin-RING E3 ubiquitin ligase responsible for ubiquitinating substrate proteins and targeting them for proteasome-mediated degradation. In human cells,…

Continue Reading The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development

FBXW7 in breast cancer: mechanism of action and therapeutic potential

Review doi: 10.1186/s13046-023-02767-1. Affiliations Expand Affiliations 1 Chongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosisand, Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, College of Medical Technology , Chengdu University of Traditional Chinese Medicine, Chengdu, China. 2 Chongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosisand, Treatment of Infectious…

Continue Reading FBXW7 in breast cancer: mechanism of action and therapeutic potential

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

Abstract Somatic driver mutations, in genes such as FBXW7, have been discovered in phenotypically normal colonic tissue, however their role in cancer initiation remains elusive. Here, using patient-derived human colon organoids as models of early tumour evolution we investigate the consequences of FBXW7 mutations in normal and gene-edited organoids. We…

Continue Reading Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

Cells | Free Full-Text | The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development

From yeast to humans, FBXW7 proteins share three conserved domains: a dimerization domain required for interaction of two FBXW7 protomers, an F-box domain that mediates FBXW7 interaction with SKP1, and a substrate-binding domain composed of eight WD40 repeats (Figure 1A). The human FBXW7 gene permits expression of three isoforms that…

Continue Reading Cells | Free Full-Text | The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development

Wilm’s Tumor Contributors Unearthed With Sequencing, Epigenetic Analyses

Researchers in Denmark and Italy explore genetic and epigenetic contributors to a type of pediatric kidney cancer known as Wilm’s tumor (WT) in a paper appearing in the Journal of Medical Genetics. With the help of whole-genome sequencing, pyrosequencing, and methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA), the team searched for…

Continue Reading Wilm’s Tumor Contributors Unearthed With Sequencing, Epigenetic Analyses

MicroRNA-92b targets tumor suppressor gene FBXW7 in glioblastoma

1University of Puerto Rico, Medical Sciences Campus, Puerto Rico 2Comprehensive Cancer Center, University of Puerto Rico, Puerto Rico 3University of Puerto Rico, Medical Sciences Campus, Puerto Rico 4University of Puerto Rico, Río Piedras Campus, Puerto Rico The final, formatted version…

Continue Reading MicroRNA-92b targets tumor suppressor gene FBXW7 in glioblastoma

Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc

In this study, by performing comprehensive gene expression analysis, we found that intracellular Ca2+ activates c-Myc target genes, and elucidated the molecular mechanism of this activation. Ca2+ signaling triggers intracellular biochemical responses by activating various calcium-binding proteins such as calmodulin, calcineurin, and CAMKII. We demonstrated that intracellular Ca2+ concentration modulates…

Continue Reading Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc

Repare Therapeutics Provides Business Update and Reports Second Quarter 2023 Financial Results

Presented initial camonsertib-PARPi combination Phase 1/2 clinical data at AACR 2023 demonstrating durable clinical benefit across tumor types, genomic alterations, PARPi choice or platinum resistance Roche has included a camonsertib-based arm in its Phase 2 TAPISTRY study and its Phase 1/2 Morpheus Lung study of multiple combinations in metastatic non-small…

Continue Reading Repare Therapeutics Provides Business Update and Reports Second Quarter 2023 Financial Results

Talk:FBXW7 – Wikipedia

From Wikipedia, the free encyclopedia Molecular Biology: MCB Stub‑class This article is within the scope of WikiProject Molecular Biology, a collaborative effort to improve the coverage of Molecular Biology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see…

Continue Reading Talk:FBXW7 – Wikipedia

Prognostic Significance of Notch1 and Fbxw7 Mutations in Pediatric T-All

Özet The NOTCH signaling pathway plays important role in the development of multicellular organisms, as it regulates cell proliferation, survival, and differentiation. In adults, it is essential for the T- or B-lymphocyte lineage commitment. NOTCH1 and FBXW7 mutations both lead the activation of the NOTCH1 pathway and are found in…

Continue Reading Prognostic Significance of Notch1 and Fbxw7 Mutations in Pediatric T-All

KPNA2 Silencing, Regulated by E3 Ubiquitin Ligase FBXW7, Alleviates Endothelial Dysfunction and Inflammation Through Inhibiting the Nuclear Translocation of p65 and IRF3: A Possible Therapeutic Approach for Atherosclerosis

doi: 10.1007/s10753-023-01863-w. Online ahead of print. Affiliations Expand Affiliations 1 Department of Radiology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, Liaoning, People’s Republic of China. 2 Department of Radiology, Shengjing Hospital of China Medical University, 39 Huaxiang Road, Shenyang, 110022, Liaoning, People’s Republic of China. zhengjh@sj-hospital.org….

Continue Reading KPNA2 Silencing, Regulated by E3 Ubiquitin Ligase FBXW7, Alleviates Endothelial Dysfunction and Inflammation Through Inhibiting the Nuclear Translocation of p65 and IRF3: A Possible Therapeutic Approach for Atherosclerosis

Sci-Hub | In vitro effects of FBXW7 mutation in serous endometrial cancer: Increased levels of potentially druggable proteins and sensitivity to SI-2 and dinaciclib. Molecular Carcinogenesis

Sci-Hub | In vitro effects of FBXW7 mutation in serous endometrial cancer: Increased levels of potentially druggable proteins and sensitivity to SI-2 and dinaciclib. Molecular Carcinogenesis | 10.1002/mc.22867 ◂ ↓ save Urick, M. E., & Bell, D. W. (2018). In vitro effects of FBXW7 mutation in serous endometrial cancer: Increased…

Continue Reading Sci-Hub | In vitro effects of FBXW7 mutation in serous endometrial cancer: Increased levels of potentially druggable proteins and sensitivity to SI-2 and dinaciclib. Molecular Carcinogenesis

Anti-FBXW7 antibody (164673)

Western blot – FBXW7 Polyclonal Antibody Western blot analysis of extracts of various cell lines, using FBXW7 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit .Exposure time: 60s. Immunohistochemistry – FBXW7 Polyclonal…

Continue Reading Anti-FBXW7 antibody (164673)

The Role of FBXW7 in Gynecologic Malignancies

The F-Box and WD Repeat Domain Containing 7 (FBXW7) protein has been shown to regulate cellular growth and act as a tumor suppressor. This protein, also known as FBW7, hCDC4, SEL10 or hAGO, is encoded by the gene FBXW7. It is a crucial component of the Skp1-Cullin1-F-box (SCF) complex, which…

Continue Reading The Role of FBXW7 in Gynecologic Malignancies

Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells

Colorectal cancer possesses marked intratumoral heterogeneity. While subclonal interactions between Vogelstein driver mutations have been extensively studied, less is known about competitive or cooperative effects between subclonal populations with other cancer driver mutations. FBXW7 is a cancer driver mutation which is present in close to 17% of colorectal cancer cells….

Continue Reading Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells

Exosomal circRNA: emerging insights into cancer progression and clinical application potential | Journal of Hematology & Oncology

He G, Peng X, Wei S, Yang S, Li X, Huang M, et al. Exosomes in the hypoxic TME: from release, uptake and biofunctions to clinical applications. Mol Cancer. 2022;21:19. Article  PubMed  PubMed Central  Google Scholar  Downs-Canner SM, Meier J, Vincent BG, Serody JS. B cell function in the tumor…

Continue Reading Exosomal circRNA: emerging insights into cancer progression and clinical application potential | Journal of Hematology & Oncology

Biopsies From Multiple Sites Reveal Genetic Differences in DLBCL

Patients with diffuse large B-cell lymphoma (DLBCL) may have mutational differences between biopsy sites, according to a study published in Leukemia & Lymphoma. During the study, half of the patients with DLBCL (8 out of 16) had mutational differences, including differences in TP53 mutational status, between 2 spatially distinct biopsy…

Continue Reading Biopsies From Multiple Sites Reveal Genetic Differences in DLBCL

Fbxw7 deletion leads to stem cell activation and leukemogenesis

John M. Perry1 and Linheng Li1,2,3 1 Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA; 2 Department of Pathology, Kansas University Medical Center, Kansas City, Kansas 66160, USA Abstract Recent reports have demonstrated that specific tumor suppressors are important for both maintaining hematopoietic stem cell (HSC) quiescence and…

Continue Reading Fbxw7 deletion leads to stem cell activation and leukemogenesis

Sensitization of colon cancer cells to cisplatin by Fbxw7 via negative regulation of the Nox1-mTOR pathway

doi: 10.1016/j.prp.2023.154479. Online ahead of print. Affiliations Expand Affiliations 1 Department of Emergency surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China. 2 Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: kailsichuanph2022@163.com. Item…

Continue Reading Sensitization of colon cancer cells to cisplatin by Fbxw7 via negative regulation of the Nox1-mTOR pathway

FBXW7 promotes autophagy and inhibits proliferation of oral squamous cell carcinoma

Background: F-box and WD repeat domain containing 7 (FBXW7) is a critical tumor suppressor. The expression of FBXW7 is decreased in oral squamous cell carcinoma (OSCC) tissues and shows diagnosis value. We aimed to investigate the influence of FBXW7 overexpression on OSCC cell proliferation and autophagy. Methods: In Balb/c nude…

Continue Reading FBXW7 promotes autophagy and inhibits proliferation of oral squamous cell carcinoma

Owens Foundation awards projects for cancer and Alzheimer’s research

  The William and Ella Owens Medical Research Foundation is awarding $1.5 million to UT Health San Antonio to support research projects that address brain cancers, pancreatic cancers, Alzheimer’s disease and childhood cancers. This year, the foundation will fund eight research projects from UT Health San Antonio investigators. This year’s…

Continue Reading Owens Foundation awards projects for cancer and Alzheimer’s research

Epigenetic status of FBXW7 gene and its role in Ovarian cancer pathogenesis

Background: Chromatin immunoprecipitation (ChIP) analysis revealed that the FBXW7 gene and the long non-coding RNA (LINC01588) are potential candidates in epithelial ovarian cancer (EOC) pathogenesis. However, their exact role in EOC is not yet known. Thus, the present study sheds light on the impact of the mutations/ methylation status of…

Continue Reading Epigenetic status of FBXW7 gene and its role in Ovarian cancer pathogenesis

From an unknown person to a “top class”? In-depth interpretation of the past, present and future of circular RNA

foreword Since the circRNA molecule was discovered in the plant virus genome in 1976, after more than 30 years of silence, it finally became a blockbuster in 2012, and quickly became a new generation of star molecules in the following years. In the past ten years, as scientific researchers have…

Continue Reading From an unknown person to a “top class”? In-depth interpretation of the past, present and future of circular RNA

Researchers Target Commonly Mutated or Deleted Gene in Gynecological Cancers

Newswise — A gene regulating the F-Box and WD Repeat Domain Containing 7 (FBXW7) protein is frequently mutated or deleted in various types of human cancer, including gynecological cancers. Such FBXW7 mutations have been associated with poor prognosis due to increased resistance to treatment. Hence, detection of the FBXW7 mutation…

Continue Reading Researchers Target Commonly Mutated or Deleted Gene in Gynecological Cancers

Cells | Free Full-Text | The Role of FBXW7 in Gynecologic Malignancies

Cells 2023, 12(10), 1415; doi.org/10.3390/cells12101415 (registering DOI) Cells 2023, 12(10), 1415; doi.org/10.3390/cells12101415 (registering DOI) Received: 22 March 2023 / Revised: 28 April 2023 / Accepted: 15 May 2023 / Published: 17 May 2023 Round 1 Reviewer 1 Report this is an interesting paper on the role of FBXW7, a protein that regulates…

Continue Reading Cells | Free Full-Text | The Role of FBXW7 in Gynecologic Malignancies

A widely used pan-isoform-FBXW7 antibody used in cell cycle studies does not detect FBXW7

doi: 10.1080/15384101.2023.2210044. Online ahead of print. Affiliations Expand Affiliation 1 Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK. Item in Clipboard Hannah Ennis et al. Cell Cycle. 2023. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1080/15384101.2023.2210044. Online ahead of print. Affiliation 1 Wellcome-Wolfson Institute for Experimental Medicine,…

Continue Reading A widely used pan-isoform-FBXW7 antibody used in cell cycle studies does not detect FBXW7

CircRNAs: versatile players and new targets in organ fibrosis | Cell Communication and Signaling

Organ fibrosis is the final common pathological pathway of many chronic diseases and is characterized by various injuries and insults with maladaptive tissue repair, followed by excessive collagen deposition into the extracellular matrix (ECM). Structural alterations lead to tissue stiffness, vascular rarefaction, hypoxia, proliferation, differentiation and activation of fibroblasts and…

Continue Reading CircRNAs: versatile players and new targets in organ fibrosis | Cell Communication and Signaling

F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway

Hepatic fibrosis (HF) is a precursor of liver cirrhosis, and activated hepatic stellate cells are an important driver of fibrosis. F-box and WD repeat domain containing 7 (FBXW7) expression level is down-regulated in HF, but the underlying mechanism is yet to be elucidated. The interaction between FBXW7 and delta-like ligand…

Continue Reading F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway

Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers

Background: FBXW7 is recognized as a critical tumor suppressor gene and a component of the ubiquitin-proteasome system, mediating the degradation of multiple oncogenic proteins, including c-MYC, Cyclin E, c-Jun, Notch, p53. Around 16% of colorectal cancer (CRC) patients carried FBXW7 somatic mutations, while a comprehensive characterization of FBXW7 somatic mutations…

Continue Reading Comprehensive characterization of FBXW7 mutational and clinicopathological profiles in human colorectal cancers

Fbxw7 Targeted Allele Detail MGI Mouse (MGI:3798866)

Fbxw7tm1IaaiTargeted Allele Detail Symbol: Fbxw7tm1Iaai Name: F-box and WD-40 domain protein 7; targeted mutation 1, Iannis Aifantis MGI ID: MGI:3798866 Synonyms: Fbw7flox Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3 Alliance: Fbxw7tm1Iaai page Germline Transmission:  Earliest citation of germline transmission: J:137138 Parent Cell Line:  Not Specified…

Continue Reading Fbxw7 Targeted Allele Detail MGI Mouse (MGI:3798866)

FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation

Background: Increasing evidence suggests that FBXW7 has a high frequency of mutations in esophageal squamous cell carcinoma (ESCC). However, the function of FBXW7, especially the mutations, is not clear. This study was designed to investigate the functional significance of FBXW7 loss of function and underlying mechanism in ESCC. Methods: Immunofluorescence…

Continue Reading FBXW7 loss of function promotes esophageal squamous cell carcinoma progression via elevating MAP4 and ERK phosphorylation

FBXW7 attenuates tumor drug resistance and enhances the efficacy of immunotherapy

Review . 2023 Mar 14;13:1147239. doi: 10.3389/fonc.2023.1147239. eCollection 2023. Affiliations Expand Affiliations 1 Department of Oncology, Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao, China. 2 Qingdao Cancer Institute, Qingdao, China. 3 School of Basic Medicine, Qingdao University, Qingdao, China. 4 Department of Pharmacology, School of Pharmacy, Qingdao University,…

Continue Reading FBXW7 attenuates tumor drug resistance and enhances the efficacy of immunotherapy

Colorectal Cancer – everolimus – FBXW7 R505C

Ten patients were treated on a protocol containing an mTOR inhibitor, with a median time to treatment failure of 2.8 months (range, 1.3–6.8)…One patient with liver cancer (fibrolamellar subtype) continues to have a prolonged stable disease for 6.8+ months…In patients with advanced cancers, somatic mutations in FBXW7 usually occur with…

Continue Reading Colorectal Cancer – everolimus – FBXW7 R505C

G9a promotes immune suppression by targeting the Fbxw7/Notch pathway in glioma stem cells

Aim: Immunotherapy for glioblastoma multiforme (GBM) is limited because of a strongly immunosuppressive tumor microenvironment (TME). Remodeling the immune TME is an effective strategy to eliminate GBM immunotherapy resistance. Glioma stem cells (GSCs) are inherently resistant to chemotherapy and radiotherapy and involved in immune evasion mechanism. This study aimed to…

Continue Reading G9a promotes immune suppression by targeting the Fbxw7/Notch pathway in glioma stem cells

IJMS | Free Full-Text | Different miRNAs Related to FBXW7 Mutations or High Mitotic Indices Contribute to Rectal Neuroendocrine Tumors: A Pilot Study

1. Introduction Neuroendocrine tumors (NETs) are a heterogeneous group of tumors originating from neuroendocrine cells and harbor malignant potential [1,2]. The incidence of NETs is becoming more common worldwide, and their characteristics and behavior can vary widely [1,2]. The incidence of gastrointestinal NETs depends on the primary tumor site, with…

Continue Reading IJMS | Free Full-Text | Different miRNAs Related to FBXW7 Mutations or High Mitotic Indices Contribute to Rectal Neuroendocrine Tumors: A Pilot Study

FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2

FBXW7 is a member of the F-box protein family, which functions as the substrate recognition component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several oncoproteins such as c-Jun, c-Myc, Cyclin E1, mTOR, and Notch1-IC. FBXW7 inactivation…

Continue Reading FBXW7 tumor suppressor regulation by dualspecificity tyrosine-regulated kinase 2

MiR-223-3p regulates the eosinophil degranulation and enhances the inflammation in allergic rhinitis by targeting FBXW7

Objectives: MiR-223-3p is a multifunctional microRNA regulated by multiple transcription factors and plays a critical role in inflammation. This paper was designed to investigate the regulatory role and mechanism of miR-223-3p in eosinophils degranulation and allergic rhinitis (AR) inflammation. Methods: OVA sensitized AR mouse model and EOL-1 cells model were…

Continue Reading MiR-223-3p regulates the eosinophil degranulation and enhances the inflammation in allergic rhinitis by targeting FBXW7

Researchers Find Genetic, Cellular Features of Early-Onset Colorectal Cancer in Chinese Patients

NEW YORK – In a new multiomics study, researchers in China have unraveled the genetic and molecular signatures of early-onset colorectal cancer (EOCRC) in Chinese patients and determined how these features differ from late-onset colorectal cancer (LOCRC). EOCRC tends to be diagnosed at a more advanced stage compared to LOCRC….

Continue Reading Researchers Find Genetic, Cellular Features of Early-Onset Colorectal Cancer in Chinese Patients

FBXW7 mediates high glucose-induced SREBP-1

Introduction Diabetic nephropathy (DN) is a type of severe complication of diabetes mellitus (DM) and is the main cause of chronic kidney disease (1). Various of mechanism are reported to be involved in the pathogenesis and development of DN, such as hyperglycemia, oxidative stress (2), mitochondrial dysfunction (3), endoplasmic reticulum…

Continue Reading FBXW7 mediates high glucose-induced SREBP-1

Anti-Fbxw7 antibody (ab192328) | Abcam

Overview Product name Description Rabbit polyclonal to Fbxw7 Host species Rabbit Tested applications Species reactivity Reacts with: Mouse, Rat, Human Immunogen Recombinant full length protein…

Continue Reading Anti-Fbxw7 antibody (ab192328) | Abcam

Fbxw7 Targeted Allele Detail MGI Mouse (MGI:3038749)

Fbxw7tm1SjeTargeted Allele Detail Symbol: Fbxw7tm1Sje Name: F-box and WD-40 domain protein 7; targeted mutation 1, Stephen Elledge MGI ID: MGI:3038749 Synonyms: Fbw7– Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3 Alliance: Fbxw7tm1Sje page Germline Transmission:  Earliest citation of germline transmission: J:88903 Parent Cell Line:  AB2.2 (ES…

Continue Reading Fbxw7 Targeted Allele Detail MGI Mouse (MGI:3038749)

IRF-1-inhibited lncRNA XIST regulated the osteogenic differentiation via miR-450b/FBXW7 axis

doi: 10.1007/s10495-023-01820-w. Online ahead of print. Affiliations Expand Affiliations 1 Department of orthopedics, Fujian Medical University Union Hospital, No.29 Xin quan Road, Gulou District, 350001, Fuzhou, Fujian, P.R. China. 2 Department of orthopedics, Fujian Medical University Union Hospital, No.29 Xin quan Road, Gulou District, 350001, Fuzhou, Fujian, P.R. China. wengeunion@fjmu.edu.cn….

Continue Reading IRF-1-inhibited lncRNA XIST regulated the osteogenic differentiation via miR-450b/FBXW7 axis

E3 ubiquitin ligase FBXW7 enhances radiosensitivity of non-small cell lung cancer cells by inhibiting SOX9 regulation of CDKN1A through ubiquitination

. 2022 Nov;102(11):1203-1213. doi: 10.1038/s41374-022-00812-9. Epub 2023 Jan 4. Affiliations Expand Affiliations 1 The Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, 830000, Urumqi, China. 2 The Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, 830000, Urumqi, China. Electronic address: lclchunling56@163.com. Item in Clipboard…

Continue Reading E3 ubiquitin ligase FBXW7 enhances radiosensitivity of non-small cell lung cancer cells by inhibiting SOX9 regulation of CDKN1A through ubiquitination

ANXA2 as a novel substrate of FBXW7 promoting esophageal squamous cell carcinoma via ERK phosphorylation

Biochem Biophys Res Commun . 2023 Jan 27;649:93-100. doi: 10.1016/j.bbrc.2023.01.082. Online ahead of print. Affiliations Expand Affiliations 1 School of Biomedical Engineering (Suzhou), Division of Life Science and Technology, University of Science and Technology of China, Hefei, 230026, China; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences,…

Continue Reading ANXA2 as a novel substrate of FBXW7 promoting esophageal squamous cell carcinoma via ERK phosphorylation

ESIRNA HUMAN FBXW7 | Merck Life Science Indonesia

ESIRNA HUMAN FBXW7 | Merck Life Science Indonesia The store will not work correctly in the case when cookies are disabled. JavaScript seems to be disabled in your browser. For the best experience on our…

Continue Reading ESIRNA HUMAN FBXW7 | Merck Life Science Indonesia

MONOCLONAL ANTI-FBXW7 | Merck Life Science Indonesia

Description Monoclonal Anti-FBXW7 antibody produced in mouse has been used in Western blotting and immunohistochemistry. F-box proteins are associated with various signaling pathways, such as nutrient sensing in yeast, conserved developmental pathways in plants and animals. These proteins mediate recognition of phosphorylated targets including Cyclin E, Myc, c-Jun, and Notch,…

Continue Reading MONOCLONAL ANTI-FBXW7 | Merck Life Science Indonesia

CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis

doi: 10.1016/j.bcp.2023.115446. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning 530021, Guangxi, PR China; Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China. 2 Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning 530021,…

Continue Reading CEMIP promotes small cell lung cancer proliferation by activation of glutamine metabolism via FBXW7/c-Myc-dependent axis

Puerarin Suppresses Glycolysis and Increases Cisplatin Chemosensitivity in Oral Squamous Cell Carcinoma via FBXW7/mTOR Signaling

This study aimed to observe the effects of puerarin on glycolysis and cisplatin sensitivity in oral squamous cell carcinoma (oSCC) cells and to explore the underlying mechanisms. CAL27 cells over- or under-expressing FBXW7 were treated with cisplatin or puerarin, and the levels of proteins involved in glycolysis as well as…

Continue Reading Puerarin Suppresses Glycolysis and Increases Cisplatin Chemosensitivity in Oral Squamous Cell Carcinoma via FBXW7/mTOR Signaling

APOBEC mutagenesis is a common process in normal human small intestine

The landscape of somatic mutation in normal human small intestinal crypts The base of each small intestinal crypt is occupied by stem cells, and the descendants of a single recent ancestor stem cell comprise most cells in each crypt19,20. Therefore, isolation of single crypts provides relatively homogeneous clones of cells…

Continue Reading APOBEC mutagenesis is a common process in normal human small intestine

Phenotypes for Fbxw7 Speer6-ps1 MGI:6157293 MGI Mouse

Phenotypes Associated with This Genotype Find Mice Using the International Mouse Strain Resource (IMSR)Mouse lines carrying: Fbxw7tm1Iken mutation (0 available); any Fbxw7 mutation (64 available) Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available) endocrine/exocrine glands • hyperplasia of bile ducts throughout the liver at 12 months of age •…

Continue Reading Phenotypes for Fbxw7 Speer6-ps1 MGI:6157293 MGI Mouse

Fbxw7 MGI Mouse Gene Detail – MGI:1354695

Transcription Start Site Location Distance from Gene 5′-end Tssr29740 Chr3:84721890-84721965 (+) -647 bp Tssr29741 Chr3:84724613-84724619 (+) 2,041 bp Tssr29742 Chr3:84737093-84737097 (+) 14,520 bp Tssr29743 Chr3:84750533-84750543 (+) 27,963 bp Tssr29744 Chr3:84766128-84766133 (+) 43,556 bp Tssr29745 Chr3:84776785-84776792 (+) 54,214 bp Tssr29746 Chr3:84813203-84813215 (+) 90,634 bp Tssr29747 Chr3:84819778-84819790 (+) 97,209 bp Tssr29748 Chr3:84819860-84819879…

Continue Reading Fbxw7 MGI Mouse Gene Detail – MGI:1354695

Fbxw7 Targeted Allele Detail MGI Mouse (MGI:5007620)

Fbxw7tm1ItomTargeted Allele Detail Symbol: Fbxw7tm1Itom Name: F-box and WD-40 domain protein 7; targeted mutation 1, Ian Tomlinson MGI ID: MGI:5007620 Synonyms: Fbxw7flox, Fbxw7fl(R482Q) Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3 Alliance: Fbxw7tm1Itom page Germline Transmission:  Earliest citation of germline transmission: J:172214 Parent Cell Line:  Not…

Continue Reading Fbxw7 Targeted Allele Detail MGI Mouse (MGI:5007620)

FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A

. 2022 Sep 14;2022:3242482. doi: 10.1155/2022/3242482. eCollection 2022. Affiliations Expand Affiliation 1 College of Clinical Medicine, Guizhou Medical University, Guiyang, 550000 Guizhou, China. Item in Clipboard Xing Wang et al. Stem Cells Int. 2022. Show details Display options Display options Format AbstractPubMedPMID . 2022 Sep 14;2022:3242482. doi: 10.1155/2022/3242482. eCollection 2022. Affiliation…

Continue Reading FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A

FBXW7 inactivation induces cellular senescence via accumulation of p53

F-box and WD repeat domain containing 7 (FBXW7) acts as a substrate receptor of SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase and plays crucial roles in the regulation of several cellular processes, including cell growth, division, and differentiation, by targeting diverse key regulators for degradation. However, its role in regulating cellular senescence…

Continue Reading FBXW7 inactivation induces cellular senescence via accumulation of p53

FBXW7 and Its Downstream NOTCH Pathway Could be Potential Indicators of Organ-Free Metastasis in Colorectal Cancer

doi: 10.3389/fonc.2021.783564. eCollection 2021. Dongzheng Li  1 , Shiye Jiang  1 , Xin Zhou  1 , Chengshuai Si  1 , Peng Shao  1 , Qian Jiang  1 , Liuqing Zhu  2 , Lu Shen  2 , Qi Meng  2 , Jiani C Yin  2 , Yang Shao  2   3 , Yueming Sun  4 , Liu Yang  1 Affiliations Expand Affiliations 1…

Continue Reading FBXW7 and Its Downstream NOTCH Pathway Could be Potential Indicators of Organ-Free Metastasis in Colorectal Cancer

Circular RNA circ-BNC2 (hsa_circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p/ FBXW7 axis | Journal of Ovarian Research

Ethics statement and patient samples 40 pairs of OC tissues and adjacent tissue samples were collected from patients who were diagnosed with OC and received surgical resection in the Affiliated Hospital of Zunyi Medical University. None of the patients received any anti-cancer treatment before surgery, and all samples were immediately…

Continue Reading Circular RNA circ-BNC2 (hsa_circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p/ FBXW7 axis | Journal of Ovarian Research

Spanish researchers find ‘weak point’ in multi-drug resistant tumors

Researchers from the National Cancer Research Center (CNIO) have discovered in cell lines one of the causes of multi-drug resistance and an strategy Potential for fight it. One of the great challenges of cancer is to understand why there is the patients What they don’t answer to treatments. In some…

Continue Reading Spanish researchers find ‘weak point’ in multi-drug resistant tumors

FBXO9 Mediates the Cancer-Promoting Effects of ZNF143 by Degrading FBXW7 and Facilitates Drug Resistance in Hepatocellular Carcinoma

doi: 10.3389/fonc.2022.930220. eCollection 2022. Zhenyu Wang  1 , Xiaoxia Chen  1   2 , Lianer Zhou  1 , Xinge Zhao  1 , Chao Ge  1 , Fangyu Zhao  1 , Haiyang Xie  3 , Taoyang Chen  4 , Hua Tian  1 , Hong Li  1 , Jinjun Li  1 Affiliations Expand Affiliations 1 State Key Laboratory of Oncogenes and Related…

Continue Reading FBXO9 Mediates the Cancer-Promoting Effects of ZNF143 by Degrading FBXW7 and Facilitates Drug Resistance in Hepatocellular Carcinoma

Dog lymphoma, new genetic mutations discovered. Hopes for man too

TURIN – Large B cell lymphoma is one of the most frequent cancers in dogs and is considered a good model for the study of the same pathology in humans. The study was published in the prestigious Nature journal, Lab Animal. Researchers of a European team coordinated by the professor…

Continue Reading Dog lymphoma, new genetic mutations discovered. Hopes for man too

Mechanical overload promotes chondrocyte senescence and osteoarthritis development through downregulation of FBXW7

   Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis (OA) . This study explores the role of mechanical stress in cartilage aging and identifies mechanistic associations during osteoarthritis (OA) progression .    Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis…

Continue Reading Mechanical overload promotes chondrocyte senescence and osteoarthritis development through downregulation of FBXW7

Biogenesis, biology and characterization of circular RNAs

Biogenesis, biology and characterization of circular RNAs Kristensen LS et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. (2019) Summary text Biogenesis and properties of circRNAs Biogenesis of cirRNA Characteristics of circRNAs Discover and analyze circRNAs circRNA genome-wide analysis CircRNA site-specific analysis circRNA visualization Biological functions…

Continue Reading Biogenesis, biology and characterization of circular RNAs

New neurodevelopmental disorder discovered

An Australian-led international research collaboration has discovered a new neurodevelopmental disorder after uncovering its link to a tumour suppressor gene, ending the diagnostic journey for 32 families around the world. Murdoch Children’s Research Institute (MCRI) researchers, along with their international peers, found variations in the FBXW7 gene were associated with…

Continue Reading New neurodevelopmental disorder discovered

Researchers Discover New Neurodevelopmental Disorder

Researchers have discovered a new neurodevelopmental disorder after uncovering its link to a tumor suppressor gene. Credit: Edmonton Economic Development Corporation Australian scientists were recently able to give long-sought after answers to 35 people and families when they discovered a new neurodevelopmental disorder after uncovering its link to a tumor…

Continue Reading Researchers Discover New Neurodevelopmental Disorder

IJMS | Free Full-Text | Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels

Int. J. Mol. Sci. 2022, 23(6), 3320; doi.org/10.3390/ijms23063320 (registering DOI) Int. J. Mol. Sci. 2022, 23(6), 3320; doi.org/10.3390/ijms23063320 (registering DOI) Received: 23 February 2022 / Revised: 16 March 2022 / Accepted: 17 March 2022 / Published: 19 March 2022 Round 1 Reviewer 1 Report This manuscript by Singh and co-workers defines a…

Continue Reading IJMS | Free Full-Text | Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels

Function of SYDE C2-RhoGAP family as signaling hubs for neuronal development deduced by computational analysis

Hallam, S. J., Goncharov, A., McEwen, J., Baran, R. & Jin, Y. Syd-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains specifies axon identity in C. elegans. Nat. Neurosci. 5, 1137–1146 (2002). CAS  PubMed  Google Scholar  Xu, Y. & Quinn, C. C. SYD-1 promotes multiple developmental steps leading to…

Continue Reading Function of SYDE C2-RhoGAP family as signaling hubs for neuronal development deduced by computational analysis

Notch activation suppresses endothelial cell migration and sprouting via miR-223-3p targeting Fbxw7

Alabi RO, Farber G, Blobel CP (2018) Intriguing roles for endothelial ADAM10/Notch signaling in the development of organ-specific vascular beds. Physiol Rev 98:2025–2061 CAS  Article  Google Scholar  Autiero M, De Smet F, Claes F, Carmeliet P (2005) Role of neural guidance signals in blood vessel navigation. Cardiovasc Res 65:629–638 CAS …

Continue Reading Notch activation suppresses endothelial cell migration and sprouting via miR-223-3p targeting Fbxw7

Characterization of Blood- Based Molecular Profiling in Pancreatic Adenocarcinoma

Introduction Most cases of pancreatic adenocarcinoma (PDAC) are diagnosed in the metastatic or locally advanced stage. It is the fourth leading cause of cancer death in the United States,1,2 with a 5-year overall survival (OS) around 10% in this country2 despite years of research and therapeutic development. For those patients…

Continue Reading Characterization of Blood- Based Molecular Profiling in Pancreatic Adenocarcinoma

Valine tRNA levels and availability regulate complex I assembly in leukaemia

1. Rapino, F. et al. Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature 558, 605–609 (2018). CAS  PubMed  Google Scholar  2. Goodarzi, H. et al. Modulated expression of specific tRNAs drives gene expression and cancer progression. Cell 165, 1416–1427 (2016). CAS  PubMed  PubMed Central  Google Scholar  3. Wolfe, A….

Continue Reading Valine tRNA levels and availability regulate complex I assembly in leukaemia