Tag: FBXW7

. 2022 Sep 14;2022:3242482. doi: 10.1155/2022/3242482. eCollection 2022. Affiliations Expand Affiliation 1 College of Clinical Medicine, Guizhou Medical University, Guiyang, 550000 Guizhou, China. Item in Clipboard Xing Wang et al. Stem Cells Int. 2022. Show details Display options Display options Format AbstractPubMedPMID . 2022 Sep 14;2022:3242482. doi: 10.1155/2022/3242482. eCollection 2022. Affiliation…

F-box and WD repeat domain containing 7 (FBXW7) acts as a substrate receptor of SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase and plays crucial roles in the regulation of several cellular processes, including cell growth, division, and differentiation, by targeting diverse key regulators for degradation. However, its role in regulating cellular senescence…

doi: 10.3389/fonc.2021.783564. eCollection 2021. Dongzheng Li  1 , Shiye Jiang  1 , Xin Zhou  1 , Chengshuai Si  1 , Peng Shao  1 , Qian Jiang  1 , Liuqing Zhu  2 , Lu Shen  2 , Qi Meng  2 , Jiani C Yin  2 , Yang Shao  2   3 , Yueming Sun  4 , Liu Yang  1 Affiliations Expand Affiliations 1…

Ethics statement and patient samples 40 pairs of OC tissues and adjacent tissue samples were collected from patients who were diagnosed with OC and received surgical resection in the Affiliated Hospital of Zunyi Medical University. None of the patients received any anti-cancer treatment before surgery, and all samples were immediately…

Researchers from the National Cancer Research Center (CNIO) have discovered in cell lines one of the causes of multi-drug resistance and an strategy Potential for fight it. One of the great challenges of cancer is to understand why there is the patients What they don’t answer to treatments. In some…

doi: 10.3389/fonc.2022.930220. eCollection 2022. Zhenyu Wang  1 , Xiaoxia Chen  1   2 , Lianer Zhou  1 , Xinge Zhao  1 , Chao Ge  1 , Fangyu Zhao  1 , Haiyang Xie  3 , Taoyang Chen  4 , Hua Tian  1 , Hong Li  1 , Jinjun Li  1 Affiliations Expand Affiliations 1 State Key Laboratory of Oncogenes and Related…

TURIN – Large B cell lymphoma is one of the most frequent cancers in dogs and is considered a good model for the study of the same pathology in humans. The study was published in the prestigious Nature journal, Lab Animal. Researchers of a European team coordinated by the professor…

   Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis (OA) . This study explores the role of mechanical stress in cartilage aging and identifies mechanistic associations during osteoarthritis (OA) progression .    Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis…

Biogenesis, biology and characterization of circular RNAs Kristensen LS et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. (2019) Summary text Biogenesis and properties of circRNAs Biogenesis of cirRNA Characteristics of circRNAs Discover and analyze circRNAs circRNA genome-wide analysis CircRNA site-specific analysis circRNA visualization Biological functions…

An Australian-led international research collaboration has discovered a new neurodevelopmental disorder after uncovering its link to a tumour suppressor gene, ending the diagnostic journey for 32 families around the world. Murdoch Children’s Research Institute (MCRI) researchers, along with their international peers, found variations in the FBXW7 gene were associated with…

Researchers have discovered a new neurodevelopmental disorder after uncovering its link to a tumor suppressor gene. Credit: Edmonton Economic Development Corporation Australian scientists were recently able to give long-sought after answers to 35 people and families when they discovered a new neurodevelopmental disorder after uncovering its link to a tumor…

Int. J. Mol. Sci. 2022, 23(6), 3320; doi.org/10.3390/ijms23063320 (registering DOI) Int. J. Mol. Sci. 2022, 23(6), 3320; doi.org/10.3390/ijms23063320 (registering DOI) Received: 23 February 2022 / Revised: 16 March 2022 / Accepted: 17 March 2022 / Published: 19 March 2022 Round 1 Reviewer 1 Report This manuscript by Singh and co-workers defines a…

Hallam, S. J., Goncharov, A., McEwen, J., Baran, R. & Jin, Y. Syd-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains specifies axon identity in C. elegans. Nat. Neurosci. 5, 1137–1146 (2002). CAS  PubMed  Google Scholar  Xu, Y. & Quinn, C. C. SYD-1 promotes multiple developmental steps leading to…

Alabi RO, Farber G, Blobel CP (2018) Intriguing roles for endothelial ADAM10/Notch signaling in the development of organ-specific vascular beds. Physiol Rev 98:2025–2061 CAS  Article  Google Scholar  Autiero M, De Smet F, Claes F, Carmeliet P (2005) Role of neural guidance signals in blood vessel navigation. Cardiovasc Res 65:629–638 CAS …

Introduction Most cases of pancreatic adenocarcinoma (PDAC) are diagnosed in the metastatic or locally advanced stage. It is the fourth leading cause of cancer death in the United States,1,2 with a 5-year overall survival (OS) around 10% in this country2 despite years of research and therapeutic development. For those patients…

1. Rapino, F. et al. Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature 558, 605–609 (2018). CAS  PubMed  Google Scholar  2. Goodarzi, H. et al. Modulated expression of specific tRNAs drives gene expression and cancer progression. Cell 165, 1416–1427 (2016). CAS  PubMed  PubMed Central  Google Scholar  3. Wolfe, A….