Tag: FBXW7

FBXW7 Reduces the Cancer Stem Cell-Like Properties of Hepatocellular Carcinoma by Regulating the Ubiquitination and Degradation of ACTL6A

. 2022 Sep 14;2022:3242482. doi: 10.1155/2022/3242482. eCollection 2022. Affiliations Expand Affiliation 1 College of Clinical Medicine, Guizhou Medical University, Guiyang, 550000 Guizhou, China. Item in Clipboard Xing Wang et al. Stem Cells Int. 2022. Show details Display options Display options Format AbstractPubMedPMID . 2022 Sep 14;2022:3242482. doi: 10.1155/2022/3242482. eCollection 2022. Affiliation…

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FBXW7 inactivation induces cellular senescence via accumulation of p53

F-box and WD repeat domain containing 7 (FBXW7) acts as a substrate receptor of SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase and plays crucial roles in the regulation of several cellular processes, including cell growth, division, and differentiation, by targeting diverse key regulators for degradation. However, its role in regulating cellular senescence…

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FBXW7 and Its Downstream NOTCH Pathway Could be Potential Indicators of Organ-Free Metastasis in Colorectal Cancer

doi: 10.3389/fonc.2021.783564. eCollection 2021. Dongzheng Li  1 , Shiye Jiang  1 , Xin Zhou  1 , Chengshuai Si  1 , Peng Shao  1 , Qian Jiang  1 , Liuqing Zhu  2 , Lu Shen  2 , Qi Meng  2 , Jiani C Yin  2 , Yang Shao  2   3 , Yueming Sun  4 , Liu Yang  1 Affiliations Expand Affiliations 1…

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Circular RNA circ-BNC2 (hsa_circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p/ FBXW7 axis | Journal of Ovarian Research

Ethics statement and patient samples 40 pairs of OC tissues and adjacent tissue samples were collected from patients who were diagnosed with OC and received surgical resection in the Affiliated Hospital of Zunyi Medical University. None of the patients received any anti-cancer treatment before surgery, and all samples were immediately…

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Spanish researchers find ‘weak point’ in multi-drug resistant tumors

Researchers from the National Cancer Research Center (CNIO) have discovered in cell lines one of the causes of multi-drug resistance and an strategy Potential for fight it. One of the great challenges of cancer is to understand why there is the patients What they don’t answer to treatments. In some…

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FBXO9 Mediates the Cancer-Promoting Effects of ZNF143 by Degrading FBXW7 and Facilitates Drug Resistance in Hepatocellular Carcinoma

doi: 10.3389/fonc.2022.930220. eCollection 2022. Zhenyu Wang  1 , Xiaoxia Chen  1   2 , Lianer Zhou  1 , Xinge Zhao  1 , Chao Ge  1 , Fangyu Zhao  1 , Haiyang Xie  3 , Taoyang Chen  4 , Hua Tian  1 , Hong Li  1 , Jinjun Li  1 Affiliations Expand Affiliations 1 State Key Laboratory of Oncogenes and Related…

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Dog lymphoma, new genetic mutations discovered. Hopes for man too

TURIN – Large B cell lymphoma is one of the most frequent cancers in dogs and is considered a good model for the study of the same pathology in humans. The study was published in the prestigious Nature journal, Lab Animal. Researchers of a European team coordinated by the professor…

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Mechanical overload promotes chondrocyte senescence and osteoarthritis development through downregulation of FBXW7

   Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis (OA) . This study explores the role of mechanical stress in cartilage aging and identifies mechanistic associations during osteoarthritis (OA) progression .    Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis…

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Biogenesis, biology and characterization of circular RNAs

Biogenesis, biology and characterization of circular RNAs Kristensen LS et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. (2019) Summary text Biogenesis and properties of circRNAs Biogenesis of cirRNA Characteristics of circRNAs Discover and analyze circRNAs circRNA genome-wide analysis CircRNA site-specific analysis circRNA visualization Biological functions…

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New neurodevelopmental disorder discovered

An Australian-led international research collaboration has discovered a new neurodevelopmental disorder after uncovering its link to a tumour suppressor gene, ending the diagnostic journey for 32 families around the world. Murdoch Children’s Research Institute (MCRI) researchers, along with their international peers, found variations in the FBXW7 gene were associated with…

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Researchers Discover New Neurodevelopmental Disorder

Researchers have discovered a new neurodevelopmental disorder after uncovering its link to a tumor suppressor gene. Credit: Edmonton Economic Development Corporation Australian scientists were recently able to give long-sought after answers to 35 people and families when they discovered a new neurodevelopmental disorder after uncovering its link to a tumor…

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IJMS | Free Full-Text | Systematic Discovery of FBXW7-Binding Phosphodegrons Highlights Mitogen-Activated Protein Kinases as Important Regulators of Intracellular Protein Levels

Int. J. Mol. Sci. 2022, 23(6), 3320; doi.org/10.3390/ijms23063320 (registering DOI) Int. J. Mol. Sci. 2022, 23(6), 3320; doi.org/10.3390/ijms23063320 (registering DOI) Received: 23 February 2022 / Revised: 16 March 2022 / Accepted: 17 March 2022 / Published: 19 March 2022 Round 1 Reviewer 1 Report This manuscript by Singh and co-workers defines a…

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Function of SYDE C2-RhoGAP family as signaling hubs for neuronal development deduced by computational analysis

Hallam, S. J., Goncharov, A., McEwen, J., Baran, R. & Jin, Y. Syd-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains specifies axon identity in C. elegans. Nat. Neurosci. 5, 1137–1146 (2002). CAS  PubMed  Google Scholar  Xu, Y. & Quinn, C. C. SYD-1 promotes multiple developmental steps leading to…

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Notch activation suppresses endothelial cell migration and sprouting via miR-223-3p targeting Fbxw7

Alabi RO, Farber G, Blobel CP (2018) Intriguing roles for endothelial ADAM10/Notch signaling in the development of organ-specific vascular beds. Physiol Rev 98:2025–2061 CAS  Article  Google Scholar  Autiero M, De Smet F, Claes F, Carmeliet P (2005) Role of neural guidance signals in blood vessel navigation. Cardiovasc Res 65:629–638 CAS …

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Characterization of Blood- Based Molecular Profiling in Pancreatic Adenocarcinoma

Introduction Most cases of pancreatic adenocarcinoma (PDAC) are diagnosed in the metastatic or locally advanced stage. It is the fourth leading cause of cancer death in the United States,1,2 with a 5-year overall survival (OS) around 10% in this country2 despite years of research and therapeutic development. For those patients…

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Valine tRNA levels and availability regulate complex I assembly in leukaemia

1. Rapino, F. et al. Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature 558, 605–609 (2018). CAS  PubMed  Google Scholar  2. Goodarzi, H. et al. Modulated expression of specific tRNAs drives gene expression and cancer progression. Cell 165, 1416–1427 (2016). CAS  PubMed  PubMed Central  Google Scholar  3. Wolfe, A….

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