Tag: FBXW7

John M. Perry1 and Linheng Li1,2,3 1 Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA; 2 Department of Pathology, Kansas University Medical Center, Kansas City, Kansas 66160, USA Abstract Recent reports have demonstrated that specific tumor suppressors are important for both maintaining hematopoietic stem cell (HSC) quiescence and…

doi: 10.1016/j.prp.2023.154479. Online ahead of print. Affiliations Expand Affiliations 1 Department of Emergency surgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China. 2 Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China. Electronic address: kailsichuanph2022@163.com. Item…

Background: F-box and WD repeat domain containing 7 (FBXW7) is a critical tumor suppressor. The expression of FBXW7 is decreased in oral squamous cell carcinoma (OSCC) tissues and shows diagnosis value. We aimed to investigate the influence of FBXW7 overexpression on OSCC cell proliferation and autophagy. Methods: In Balb/c nude…

  The William and Ella Owens Medical Research Foundation is awarding $1.5 million to UT Health San Antonio to support research projects that address brain cancers, pancreatic cancers, Alzheimer’s disease and childhood cancers. This year, the foundation will fund eight research projects from UT Health San Antonio investigators. This year’s…

Background: Chromatin immunoprecipitation (ChIP) analysis revealed that the FBXW7 gene and the long non-coding RNA (LINC01588) are potential candidates in epithelial ovarian cancer (EOC) pathogenesis. However, their exact role in EOC is not yet known. Thus, the present study sheds light on the impact of the mutations/ methylation status of…

foreword Since the circRNA molecule was discovered in the plant virus genome in 1976, after more than 30 years of silence, it finally became a blockbuster in 2012, and quickly became a new generation of star molecules in the following years. In the past ten years, as scientific researchers have…

Newswise — A gene regulating the F-Box and WD Repeat Domain Containing 7 (FBXW7) protein is frequently mutated or deleted in various types of human cancer, including gynecological cancers. Such FBXW7 mutations have been associated with poor prognosis due to increased resistance to treatment. Hence, detection of the FBXW7 mutation…

Cells 2023, 12(10), 1415; doi.org/10.3390/cells12101415 (registering DOI) Cells 2023, 12(10), 1415; doi.org/10.3390/cells12101415 (registering DOI) Received: 22 March 2023 / Revised: 28 April 2023 / Accepted: 15 May 2023 / Published: 17 May 2023 Round 1 Reviewer 1 Report this is an interesting paper on the role of FBXW7, a protein that regulates…

doi: 10.1080/15384101.2023.2210044. Online ahead of print. Affiliations Expand Affiliation 1 Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, UK. Item in Clipboard Hannah Ennis et al. Cell Cycle. 2023. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1080/15384101.2023.2210044. Online ahead of print. Affiliation 1 Wellcome-Wolfson Institute for Experimental Medicine,…

Organ fibrosis is the final common pathological pathway of many chronic diseases and is characterized by various injuries and insults with maladaptive tissue repair, followed by excessive collagen deposition into the extracellular matrix (ECM). Structural alterations lead to tissue stiffness, vascular rarefaction, hypoxia, proliferation, differentiation and activation of fibroblasts and…

Hepatic fibrosis (HF) is a precursor of liver cirrhosis, and activated hepatic stellate cells are an important driver of fibrosis. F-box and WD repeat domain containing 7 (FBXW7) expression level is down-regulated in HF, but the underlying mechanism is yet to be elucidated. The interaction between FBXW7 and delta-like ligand…

Background: FBXW7 is recognized as a critical tumor suppressor gene and a component of the ubiquitin-proteasome system, mediating the degradation of multiple oncogenic proteins, including c-MYC, Cyclin E, c-Jun, Notch, p53. Around 16% of colorectal cancer (CRC) patients carried FBXW7 somatic mutations, while a comprehensive characterization of FBXW7 somatic mutations…

Fbxw7tm1IaaiTargeted Allele Detail Symbol: Fbxw7tm1Iaai Name: F-box and WD-40 domain protein 7; targeted mutation 1, Iannis Aifantis MGI ID: MGI:3798866 Synonyms: Fbw7flox Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3 Alliance: Fbxw7tm1Iaai page Germline Transmission:  Earliest citation of germline transmission: J:137138 Parent Cell Line:  Not Specified…

Background: Increasing evidence suggests that FBXW7 has a high frequency of mutations in esophageal squamous cell carcinoma (ESCC). However, the function of FBXW7, especially the mutations, is not clear. This study was designed to investigate the functional significance of FBXW7 loss of function and underlying mechanism in ESCC. Methods: Immunofluorescence…

Review . 2023 Mar 14;13:1147239. doi: 10.3389/fonc.2023.1147239. eCollection 2023. Affiliations Expand Affiliations 1 Department of Oncology, Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao, China. 2 Qingdao Cancer Institute, Qingdao, China. 3 School of Basic Medicine, Qingdao University, Qingdao, China. 4 Department of Pharmacology, School of Pharmacy, Qingdao University,…

Ten patients were treated on a protocol containing an mTOR inhibitor, with a median time to treatment failure of 2.8 months (range, 1.3–6.8)…One patient with liver cancer (fibrolamellar subtype) continues to have a prolonged stable disease for 6.8+ months…In patients with advanced cancers, somatic mutations in FBXW7 usually occur with…

Aim: Immunotherapy for glioblastoma multiforme (GBM) is limited because of a strongly immunosuppressive tumor microenvironment (TME). Remodeling the immune TME is an effective strategy to eliminate GBM immunotherapy resistance. Glioma stem cells (GSCs) are inherently resistant to chemotherapy and radiotherapy and involved in immune evasion mechanism. This study aimed to…

1. Introduction Neuroendocrine tumors (NETs) are a heterogeneous group of tumors originating from neuroendocrine cells and harbor malignant potential [1,2]. The incidence of NETs is becoming more common worldwide, and their characteristics and behavior can vary widely [1,2]. The incidence of gastrointestinal NETs depends on the primary tumor site, with…

FBXW7 is a member of the F-box protein family, which functions as the substrate recognition component of the SCF E3 ubiquitin ligase. FBXW7 is a main tumor suppressor due to its ability to control proteasome-mediated degradation of several oncoproteins such as c-Jun, c-Myc, Cyclin E1, mTOR, and Notch1-IC. FBXW7 inactivation…

Objectives: MiR-223-3p is a multifunctional microRNA regulated by multiple transcription factors and plays a critical role in inflammation. This paper was designed to investigate the regulatory role and mechanism of miR-223-3p in eosinophils degranulation and allergic rhinitis (AR) inflammation. Methods: OVA sensitized AR mouse model and EOL-1 cells model were…

NEW YORK – In a new multiomics study, researchers in China have unraveled the genetic and molecular signatures of early-onset colorectal cancer (EOCRC) in Chinese patients and determined how these features differ from late-onset colorectal cancer (LOCRC). EOCRC tends to be diagnosed at a more advanced stage compared to LOCRC….

Introduction Diabetic nephropathy (DN) is a type of severe complication of diabetes mellitus (DM) and is the main cause of chronic kidney disease (1). Various of mechanism are reported to be involved in the pathogenesis and development of DN, such as hyperglycemia, oxidative stress (2), mitochondrial dysfunction (3), endoplasmic reticulum…

Overview Product name Description Rabbit polyclonal to Fbxw7 Host species Rabbit Tested applications Species reactivity Reacts with: Mouse, Rat, Human Immunogen Recombinant full length protein…

Fbxw7tm1SjeTargeted Allele Detail Symbol: Fbxw7tm1Sje Name: F-box and WD-40 domain protein 7; targeted mutation 1, Stephen Elledge MGI ID: MGI:3038749 Synonyms: Fbw7– Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3 Alliance: Fbxw7tm1Sje page Germline Transmission:  Earliest citation of germline transmission: J:88903 Parent Cell Line:  AB2.2 (ES…

doi: 10.1007/s10495-023-01820-w. Online ahead of print. Affiliations Expand Affiliations 1 Department of orthopedics, Fujian Medical University Union Hospital, No.29 Xin quan Road, Gulou District, 350001, Fuzhou, Fujian, P.R. China. 2 Department of orthopedics, Fujian Medical University Union Hospital, No.29 Xin quan Road, Gulou District, 350001, Fuzhou, Fujian, P.R. China. wengeunion@fjmu.edu.cn….

. 2022 Nov;102(11):1203-1213. doi: 10.1038/s41374-022-00812-9. Epub 2023 Jan 4. Affiliations Expand Affiliations 1 The Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, 830000, Urumqi, China. 2 The Affiliated Tumor Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, 830000, Urumqi, China. Electronic address: lclchunling56@163.com. Item in Clipboard…

Biochem Biophys Res Commun . 2023 Jan 27;649:93-100. doi: 10.1016/j.bbrc.2023.01.082. Online ahead of print. Affiliations Expand Affiliations 1 School of Biomedical Engineering (Suzhou), Division of Life Science and Technology, University of Science and Technology of China, Hefei, 230026, China; Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences,…

ESIRNA HUMAN FBXW7 | Merck Life Science Indonesia The store will not work correctly in the case when cookies are disabled. JavaScript seems to be disabled in your browser. For the best experience on our…

Description Monoclonal Anti-FBXW7 antibody produced in mouse has been used in Western blotting and immunohistochemistry. F-box proteins are associated with various signaling pathways, such as nutrient sensing in yeast, conserved developmental pathways in plants and animals. These proteins mediate recognition of phosphorylated targets including Cyclin E, Myc, c-Jun, and Notch,…

doi: 10.1016/j.bcp.2023.115446. Online ahead of print. Affiliations Expand Affiliations 1 Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning 530021, Guangxi, PR China; Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China. 2 Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning 530021,…

This study aimed to observe the effects of puerarin on glycolysis and cisplatin sensitivity in oral squamous cell carcinoma (oSCC) cells and to explore the underlying mechanisms. CAL27 cells over- or under-expressing FBXW7 were treated with cisplatin or puerarin, and the levels of proteins involved in glycolysis as well as…

The landscape of somatic mutation in normal human small intestinal crypts The base of each small intestinal crypt is occupied by stem cells, and the descendants of a single recent ancestor stem cell comprise most cells in each crypt19,20. Therefore, isolation of single crypts provides relatively homogeneous clones of cells…

Phenotypes Associated with This Genotype Find Mice Using the International Mouse Strain Resource (IMSR)Mouse lines carrying: Fbxw7tm1Iken mutation (0 available); any Fbxw7 mutation (64 available) Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available) endocrine/exocrine glands • hyperplasia of bile ducts throughout the liver at 12 months of age •…

Transcription Start Site Location Distance from Gene 5′-end Tssr29740 Chr3:84721890-84721965 (+) -647 bp Tssr29741 Chr3:84724613-84724619 (+) 2,041 bp Tssr29742 Chr3:84737093-84737097 (+) 14,520 bp Tssr29743 Chr3:84750533-84750543 (+) 27,963 bp Tssr29744 Chr3:84766128-84766133 (+) 43,556 bp Tssr29745 Chr3:84776785-84776792 (+) 54,214 bp Tssr29746 Chr3:84813203-84813215 (+) 90,634 bp Tssr29747 Chr3:84819778-84819790 (+) 97,209 bp Tssr29748 Chr3:84819860-84819879…

Fbxw7tm1ItomTargeted Allele Detail Symbol: Fbxw7tm1Itom Name: F-box and WD-40 domain protein 7; targeted mutation 1, Ian Tomlinson MGI ID: MGI:5007620 Synonyms: Fbxw7flox, Fbxw7fl(R482Q) Gene: Fbxw7  Location: Chr3:84722575-84886505 bp, + strand  Genetic Position: Chr3, 37.7 cM, cytoband E3.3 Alliance: Fbxw7tm1Itom page Germline Transmission:  Earliest citation of germline transmission: J:172214 Parent Cell Line:  Not…

. 2022 Sep 14;2022:3242482. doi: 10.1155/2022/3242482. eCollection 2022. Affiliations Expand Affiliation 1 College of Clinical Medicine, Guizhou Medical University, Guiyang, 550000 Guizhou, China. Item in Clipboard Xing Wang et al. Stem Cells Int. 2022. Show details Display options Display options Format AbstractPubMedPMID . 2022 Sep 14;2022:3242482. doi: 10.1155/2022/3242482. eCollection 2022. Affiliation…

F-box and WD repeat domain containing 7 (FBXW7) acts as a substrate receptor of SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase and plays crucial roles in the regulation of several cellular processes, including cell growth, division, and differentiation, by targeting diverse key regulators for degradation. However, its role in regulating cellular senescence…

doi: 10.3389/fonc.2021.783564. eCollection 2021. Dongzheng Li  1 , Shiye Jiang  1 , Xin Zhou  1 , Chengshuai Si  1 , Peng Shao  1 , Qian Jiang  1 , Liuqing Zhu  2 , Lu Shen  2 , Qi Meng  2 , Jiani C Yin  2 , Yang Shao  2   3 , Yueming Sun  4 , Liu Yang  1 Affiliations Expand Affiliations 1…

Ethics statement and patient samples 40 pairs of OC tissues and adjacent tissue samples were collected from patients who were diagnosed with OC and received surgical resection in the Affiliated Hospital of Zunyi Medical University. None of the patients received any anti-cancer treatment before surgery, and all samples were immediately…

Researchers from the National Cancer Research Center (CNIO) have discovered in cell lines one of the causes of multi-drug resistance and an strategy Potential for fight it. One of the great challenges of cancer is to understand why there is the patients What they don’t answer to treatments. In some…

doi: 10.3389/fonc.2022.930220. eCollection 2022. Zhenyu Wang  1 , Xiaoxia Chen  1   2 , Lianer Zhou  1 , Xinge Zhao  1 , Chao Ge  1 , Fangyu Zhao  1 , Haiyang Xie  3 , Taoyang Chen  4 , Hua Tian  1 , Hong Li  1 , Jinjun Li  1 Affiliations Expand Affiliations 1 State Key Laboratory of Oncogenes and Related…

TURIN – Large B cell lymphoma is one of the most frequent cancers in dogs and is considered a good model for the study of the same pathology in humans. The study was published in the prestigious Nature journal, Lab Animal. Researchers of a European team coordinated by the professor…

   Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis (OA) . This study explores the role of mechanical stress in cartilage aging and identifies mechanistic associations during osteoarthritis (OA) progression .    Objective: Mechanical overload and chondrocyte senescence play important roles in the development of osteoarthritis…

Biogenesis, biology and characterization of circular RNAs Kristensen LS et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. (2019) Summary text Biogenesis and properties of circRNAs Biogenesis of cirRNA Characteristics of circRNAs Discover and analyze circRNAs circRNA genome-wide analysis CircRNA site-specific analysis circRNA visualization Biological functions…

An Australian-led international research collaboration has discovered a new neurodevelopmental disorder after uncovering its link to a tumour suppressor gene, ending the diagnostic journey for 32 families around the world. Murdoch Children’s Research Institute (MCRI) researchers, along with their international peers, found variations in the FBXW7 gene were associated with…

Researchers have discovered a new neurodevelopmental disorder after uncovering its link to a tumor suppressor gene. Credit: Edmonton Economic Development Corporation Australian scientists were recently able to give long-sought after answers to 35 people and families when they discovered a new neurodevelopmental disorder after uncovering its link to a tumor…

Int. J. Mol. Sci. 2022, 23(6), 3320; doi.org/10.3390/ijms23063320 (registering DOI) Int. J. Mol. Sci. 2022, 23(6), 3320; doi.org/10.3390/ijms23063320 (registering DOI) Received: 23 February 2022 / Revised: 16 March 2022 / Accepted: 17 March 2022 / Published: 19 March 2022 Round 1 Reviewer 1 Report This manuscript by Singh and co-workers defines a…

Hallam, S. J., Goncharov, A., McEwen, J., Baran, R. & Jin, Y. Syd-1, a presynaptic protein with PDZ, C2 and rhoGAP-like domains specifies axon identity in C. elegans. Nat. Neurosci. 5, 1137–1146 (2002). CAS  PubMed  Google Scholar  Xu, Y. & Quinn, C. C. SYD-1 promotes multiple developmental steps leading to…

Alabi RO, Farber G, Blobel CP (2018) Intriguing roles for endothelial ADAM10/Notch signaling in the development of organ-specific vascular beds. Physiol Rev 98:2025–2061 CAS  Article  Google Scholar  Autiero M, De Smet F, Claes F, Carmeliet P (2005) Role of neural guidance signals in blood vessel navigation. Cardiovasc Res 65:629–638 CAS …

Introduction Most cases of pancreatic adenocarcinoma (PDAC) are diagnosed in the metastatic or locally advanced stage. It is the fourth leading cause of cancer death in the United States,1,2 with a 5-year overall survival (OS) around 10% in this country2 despite years of research and therapeutic development. For those patients…

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