Tag: GeCKO

Sucuri WebSite Firewall – Access Denied

If you are the site owner (or you manage this site), please whitelist your IP or if you think this block is an error please open a support ticket and make sure to include the block details (displayed in the box below), so we can assist you in troubleshooting the…

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TALIUS GECKO V2 GAMER CHAIR BLACK-GREEN

TALIUS GECKO V2 GAMER CHAIR BLACK/GREEN If you are a Hardcore Gamer and spend long hours in front of the screen you are going to need to watch your back, with the new Gecko Gaming Chair from Talius you are going to have the ergonomics of the highest-end chairs at…

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MAGeCK – BioGrids Consortium – Supported Software

AllHigh-Throughput SequencingGenomicsProteomicsVisualizationOther MAGeCK Description (Model-based Analysis of Genome-wide CRISPR-Cas9 Knockout) a computational tool to identify important genes from the recent genome-scale CRISPR-Cas9 knockout screens (or GeCKO) technology. Installation Use the following command to install this title with the CLI client: $ biogrids-cli install mageck Copy to clipboard Primary Citation* W….

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Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells

Significance The extracellular concentration of adenosine triphosphate (ATP) reaches several hundred micromoles in the inflamed tissues or tumor environment. A high concentration of ATP activates P2X7, a purinergic receptor, and induces the formation of a nonselective cation channel, accompanied by reversible phosphatidylserine (PtdSer) exposure, leading to cell lysis. Here, we…

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Bug in RStudio Script Window Management – RStudio IDE

I am running the following (open source) release of RStudio RStudio 2021.09.1+372 “Ghost Orchid” Release (8b9ced188245155642d024aa3630363df611088a, 2021-11-08) for WindowsMozilla/5.0 (Windows NT 10.0; Win64; x64) AppleWebKit/537.36 (KHTML, like Gecko) QtWebEngine/5.12.8 Chrome/69.0.3497.128 Safari/537.36 on Edition Windows 10 Home Version 21H1 Installed on ‎8/‎11/‎2020 OS build 19043.1348 Experience Windows Feature Experience Pack 120.2212.3920.0…

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Primo by Ex Libris

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Genome-wide synthetic lethal screen unveils novel CAIX-NFS1/xCT axis as a targetable vulnerability in hypoxic solid tumors

Abstract The metabolic mechanisms involved in the survival of tumor cells within the hypoxic niche remain unclear. We carried out a synthetic lethal CRISPR screen to identify survival mechanisms governed by the tumor hypoxia–induced pH regulator carbonic anhydrase IX (CAIX). We identified a redox homeostasis network containing the iron-sulfur cluster…

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