Tag: GEMMA

Dip in the Boyne for Trim Men’s Shed

Dip in h Published: Tue 19 Dec 2023, 3:20 PM A group of 16 hardy souls took to the chilly waters of the Boyne on Saturday morning for the annual Christmas swim to raise funds for Trim Men’s Shed and their redevelopment plans to provide a new premises. The event…

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New comprehensive genome data on soil invertebrates provide insights into their biodiversity

The MetaInvert project provides comprehensive genomic data on tiny and previously little-studied soil organisms such as springtails (here the species Neelus murinus). Credit: Andy Murray With the “MetaInvert” project, scientists are providing extensive genomic data on 232 species of previously little-studied organisms. They are tiny, enormously diverse, and widespread in…

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Researchers identify key mechanisms to address future treatments for hereditary blindness

There are still many enigmas about the mechanism of action of the CERKL gene, which causes retinitis pigmentosa and other hereditary vision diseases. Now, a team from the University of Barcelona has described how the lack of the CERKL gene alters the ability of retinal cells to fight oxidative stress…

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A second update on mapping the human genetic architecture of COVID-19

Broad Institute of MIT and Harvard, Cambridge, MA, USA Masahiro Kanai, Christine Stevens, Benjamin M. Neale, Mark Daly, Andrea Ganna, Amy Trankiem, Mary K. Balaconis, Samuli Ripatti, Lindo Nkambul, Mark J. Daly, Sam Bryant & Matthew Solomonson University of California San Francisco, San Francisco, CA, USA Shea J. Andrews Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland Mattia Cordioli, Mark…

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Comparative single-cell transcriptomic analysis of primate brains highlights human-specific regulatory evolution

Consensus MTG taxonomy across primates The BRAIN Initiative Cell Census Network26 generated high-resolution transcriptomic maps of the MTG in human, chimpanzee, gorilla, macaque and marmoset by applying single-nucleus transcriptomic (snRNA-seq) assays to samples isolated from between three and seven donor brains in each species (plate-based SMART-seq v4 (SSv4) for great…

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Why your department should throw a party

Hello Nature readers, would you like to get this Briefing in your inbox free every day? Sign up here. Increasing human presence in and around Bidoup Nui Ba National Park has resulted in more frequent wildfires.Credit: Evgeniya Pavlova/Getty The first centuries-long analysis of wildfires in southeast Asia has been compiled…

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why are databases like gnomad useful in population studies

99, 12451260 (2016). Genet. eCollection 2023. 36, 29362937 (2020). Genet. These assays include massively parallel regulatory assays134, which test synthetic regulatory sequences by screening variants in thousands of untranscribed or untranslated sequences for functional effects in a single experiment, and CRISPR techniques that allow for the introduction of mutations into…

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Exploiting C. diff’s Molecular ‘Superpower’

Credit: CDC Key points:  A new study shows how two molecular mechanisms work together to make C.diff “extra resistant.” The researchers discovered a novel protein that conveys resistance to a specific class of antibiotics that seems to worsen C.diff infections. With its affinity for rapidly spreading through healthcare settings, increasing…

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Swedish bacterial resistance study points to new antibiotics

A species of ordinary gut bacteria flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria are naturally resistant to many antibiotics, this can cause problems.  A study at Lund University in Sweden now shows how two molecular mechanisms can work together to make…

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Assessment of Alphafold methods in structural prediction of toxin-antitoxin systems with a focus on interface analysis

Assessment of Alphafold methods in structural prediction of toxin-antitoxin systems with a focus on interface analysis Odai, Roni Jonus (2023) BINP51 20221 Degree Projects in Bioinformatics Abstract The recent revolution in structural prediction methods has made modeling novel protein structures a feasible analysis method. In particular, the Alphafold protocol can produce…

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Biology:Circular RNA databases and resources

In molecular biology, Circular RNAs (circRNAs) refer to a class of circular RNA molecules found across all kingdoms of life.[1][2][3] Studies in 2013 have suggested that circRNAs play important regulatory roles in miRNA activity. Researchers found that CDR1as circRNA acts as a miR-7 super-sponge that contains about 70 target sites…

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A thousand-genome panel retraces the global spread and adaptation of a major fungal crop pathogen

Global genetic structure of the pathogen tracks the historical spread of wheat We assessed the evolutionary trajectory of the pathogen in conjunction with the history of global wheat cultivation (Fig. 1a). For this, we assembled a worldwide collection of Z. tritici isolates from naturally infected fields (Fig. 1b). We selected isolates covering…

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Bioinformatics Programmer II – Hybrid/Remote

#119126 Bioinformatics Programmer II – Hybrid/Remote Extended Deadline: Tue 2/21/2023 This position will remain open until a successful candidate has been identified. UCSD Layoff from Career Appointment: Apply by 10/03/2022 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor. Special Selection Applicants: Apply by 10/13/2022….

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Design studio supporting UK start ups

Hi! I’m Gemma and I currently run a small design studio, aimed at helping start-up clothing brands to launch new collections. Starting a sustainable clothing brand in the UK can be expensive, making it unattainable for many people. I work to support new brands from design through to patterns, samples…

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Calculating Log of the odds (LOD)

Calculating Log of the odds (LOD) 1 Hi all! How can I estimate LOD scores for a phenotypic trait? Is it possible to calculate it from the association files created in GEMMA? Thank you in advance! QTLs LOD • 35 views The log of the odds [ratio] can be calculated…

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Scientists Use Exotic DNA To Help Create “Climate-Proof” Crops

With a world facing the consequences of climate change, climate-resilient crops are becoming increasingly critical. By having crops that can withstand extreme environmental stressors, food security is improved, as farmers are able to grow crops even in challenging conditions. This, in turn, helps to address the issue of global hunger,…

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Bioinformatics Programmer II – Hybrid/Remote – 119126 at UC San Diego Health System

This position will remain open until a successful candidate has been identified. UCSD Layoff from Career Appointment: Apply by 10/03/2022 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor. Special Selection Applicants: Apply by 10/13/2022. Eligible Special Selection clients should contact their Disability Counselor for…

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Elisa Cowley

Elisa Cowley Wiki and Biodata Full Real Name – Elisa Cowley. Date of Birth – B/W 1968-1971. Place of Birth – Winterton, North Lincolnshire, United Kingdom. Nationality – British. Age (at death time) – B/W 51-54 years old. Education – Graduate. School/College – Private School in the United Kingdom. Death date – January 2023. Death place – The United…

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[Bug 1951033] Autopkgtest regression report (glibc/2.31-0ubuntu9.9)

All autopkgtests for the newly accepted glibc (2.31-0ubuntu9.9) for focal have finished running. The following regressions have been reported in tests triggered by the package: hilive/2.0a-3build2 (arm64) tomb/2.7+dfsg2-1 (arm64) linux-hwe-5.13/5.13.0-40.45~20.04.1 (armhf) bali-phy/3.4.1+dfsg-2build1 (s390x, arm64) smalt/0.7.6-9 (ppc64el) mariadb-10.3/1:10.3.34-0ubuntu0.20.04.1 (armhf) feersum/1.407-2 (s390x) kopanocore/8.7.0-7ubuntu1 (amd64) r-cran-ps/1.3.2-2 (s390x, ppc64el) libreoffice/1:6.4.7-0ubuntu0.20.04.4 (amd64) imagemagick/8:6.9.10.23+dfsg-2.1ubuntu11.4 (armhf) ruby-stackprof/0.2.15-2…

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San Diego scientists race to treat rare genetic diseases

Connor Dalby is in many ways your typical 12-year-old boy. He loves dipping his feet in the cool of the ocean and cruising on his bike through his Oceanside neighborhood. He’s mischievous, and he’s got a way of sticking out his chin and grinning madly when goofing off, blue eyes…

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Phenotype file for eQTL analysis using GEMMA

Phenotype file for eQTL analysis using GEMMA 0 Hello All, I appreciate it if someone could direct me in this regard. I am running eQTL analysis using GEMMA software. I have corrected the expression file with all samples (280 samples) and the genotype file is (170). I have a couple…

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