Tag: genomic
CRISPR Therapeutics AG (NASDAQ:CRSP) Expected to Announce Earnings of -$2.23 Per Share
Equities analysts predict that CRISPR Therapeutics AG (NASDAQ:CRSP – Get Rating) will post ($2.23) earnings per share for the current quarter, Zacks reports. Six analysts have made estimates for CRISPR Therapeutics’ earnings. The highest EPS estimate is ($1.92) and the lowest is ($2.48). CRISPR Therapeutics posted earnings of $9.44 per…
In vivo hypermutation and continuous evolution
Arnold, F. H. Design by directed evolution. Acc. Chem. Res. 31, 125–131 (1998). Google Scholar Packer, M. S. & Liu, D. R. Methods for the directed evolution of proteins. Nat. Rev. Genet. 16, 379–394 (2015). Google Scholar Drake, J. W., Charlesworth, B., Charlesworth, D. & Crow, J. F. Rates of…
Tempo and drivers of plant diversification in the European mountain system
Hughes, C. E. & Atchinson, G. W. The ubiquity of alpine plant radiations: from the Andes to the Hengduan Mountains. N. Phytol. 207, 275–282 (2015). Article Google Scholar Rahbek, C. et al. Humboldt’s enigma: what causes global patterns of mountain biodiversity? Science 365, 1108–1113 (2019). ADS CAS PubMed Article Google…
Variant #0000255165 (NC_000010.10:g.123278248A>G, FGFR2(NM_000141.4):c.939+1245T>C) – Global Variome shared LOVD
Variant #0000255165 (NC_000010.10:g.123278248A>G, FGFR2(NM_000141.4):c.939+1245T>C) Chromosome 10 Allele Unknown Affects function (as reported) Probably does not affect function Affects function (by curator) Not classified Classification method – Clinical classification likely benign DNA change (genomic) (Relative to hg19 / GRCh37) g.123278248A>G DNA change (hg38) g.121518734A>G Published as FGFR2(NM_022970.3):c.1035T>C (p.Y345=) ISCN – DB-ID FGFR2_000119 Variant remarks VKGL data sharing initiative Nederland Reference – ClinVar ID – dbSNP ID – Origin CLASSIFICATION record Segregation –…
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci – Nature – Alert Breaking News
Wei, K. et al. Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature 582, 259–264 (2020). ADS CAS PubMed PubMed Central Article Google Scholar Cembrowski, M. S. & Menon, V. Continuous variation within cell types of the nervous system. Trends Neurosci. 41, 337–348 (2018). CAS PubMed Article Google Scholar Maurano, M. T. et al. Systematic localization of…
Dissertations.se: HETEROPLASMY
Showing result 1 – 5 of 7 swedish dissertations containing the word Heteroplasmy. Author : Guilherme Costa Baião; Lisa Klasson; Alistair Darby; Uppsala universitet; []Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Wolbachia; Drosophila; Drosophila paulistorum; Differential Gene Expression; Reproductive Incompatibility; Reproductive Isolation; Comparative Genomics; Transcriptomics; RNA-Seq; Heteroplasmy; Mitochondria; Genomic…
genetic epidemiology postdoc
Qualification Details. Objective/methods: This report investigates by histology, immunohistochemistry and in situ hybridization the histological and . Philip Lupo, Ph.D. Dr. Lupo is a co-principal investigator in the Systems Epidemiology of Cancer Training Program and an associate professor in the Section of Hematology-Oncology in the Department of Pediatrics. . «Genetic…
A Highly Sensitive and Specific Detection Method for Mycobacterium tuberculosis Fluoroquinolone Resistance Mutations Utilizing the CRISPR-Cas13a System
Objectives CRISPR-Cas13a system-based nucleic acid detection methods are reported to have rapid and sensitive DNA detection. However, the screening strategy for crRNAs that enables CRISPR-Cas13a single-base resolution DNA detection of human pathogens remains unclear. Methods A combined rational design and target mutation-anchoring CRISPR RNA (crRNA) screening strategy was proposed. Results…
WGS Facilitates Gene Editing System Upgrade
Researchers at the Korean Institute of Life Sciences and Technology engineered an efficient, miniaturized CRISPR-Cas gene-editing system that may be more easily packed into vectors for clinical applications. Their system employs the Cas variant Cas12f1 with a guide RNA (gRNA) remodeled to mitigate off-target effects, a design that could potentially…
ACADVL – PrimePCR Assay and Template | Life Science
Control assays and synthetic DNA templates were designed to facilitate the assessment of the key experimental factors impacting your real-time PCR results. DNA Contamination Control AssayUse the PrimePCR DNA contamination control assay to determine if genomic DNA (gDNA) is present in a sample at a level that may affect PCR…
Editas Medicine (EDIT) Falls 4.05% on May 10
Last Price $ Last Trade Change $ Change Percent % Open $ Prev Close $ High $ low $ 52 Week High $ 52 Week Low $ Market Cap PE Ratio Volume Exchange EDIT – Market Data & News Trade Editas Medicine Inc (NASDAQ: EDIT) has fallen $0.45 (4.05%) and …
RefSeq Release 212 is available!
RefSeq Release 212 is now available online, from the FTP site and through NCBI’s Entrezprogramming utilities, E-utilities. This full release incorporates genomic, transcript, and protein data available as of May 2, 2022, and contains 314,915,153 records, including 229,417,182 proteins, 44,805,833 RNAs, and sequences from 119,373 organisms. The release is provided in several directories…
Frontiers | Divergence With Gene Flow and Contrasting Population Size Blur the Species Boundary in Cycas Sect. Asiorientales, as Inferred From Morphology and RAD-Seq Data
Introduction Incipient species are critical for evolutionary biologists to study speciation, but they also challenge taxonomy due to gene flow or ancestral polymorphism. The former and contrasting population size lead to larger intraspecific than interspecific variations, a phenomenon called the species-definition anomaly zone (Jiao and Yang, 2021). The latter results…
Our genetic strength in numbers
Although it’s 20 years since the first human genome was sequenced – that is, the entire collection of our DNA – our ability to ‘read’ our own instruction manual is no less astounding. We now know we have around three billion chemical base pairs that provide the code for approximately…
Genomic Study Reveals Recurrent Inversion Variants, Instability Effects
NEW YORK – A team from Germany, the US, and Italy has tallied recurrent inversions across dozens of human genomes, providing a look at haplotypes containing these polymorphisms, mechanisms that lead to new inversions, and inversion ties to genetic instability and related microdeletion or duplication conditions. The findings appeared in…
A*STAR – Agency for Science, Technology and Research hiring Bioinformatics Specialis, Laboratory of Systems Biology & Data Analytics, GIS in Singapore, Singapore
The Genome Institute of Singapore (GIS) is an institute of the Agency for Science, Technology and Research (A*STAR). It has a global vision that seeks to use genomic sciences to achieve extraordinary improvements in human health and public prosperity. GIS is dedicated to creating a social culture that is…
Pacific Biosciences Makes Progress on Sequencer Development, Amends Invitae Deal
NEW YORK – Pacific Biosciences said on Wednesday that it has made progress on the development of two sequencing platforms and announced that it is amending payment terms for its collaboration with Invitae on a high-throughput whole-genome sequencer. The Invitae collaboration is one of three R&D projects PacBio officials mentioned…
Recent developments in miRNA based recombinant protein expression in CHO
Aguiar TQ, Santos SB, Martins IM, Domingues L, Oliveira C (2019) Production and bioengineering of recombinant pharmaceuticals. Proteins: sustainable source, processing and applications. Elsevier, Amsterdam, pp 259–293 Chapter Google Scholar Amadi IM, Agrawal V, Christianson T, Bardliving C, Shamlou P, LeBowitz JH (2020) Inhibition of endogenous miR-23a/miR-377 in CHO cells…
nf-core presentation – HackMD
<!– .slide: data-background=”raw.githubusercontent.com/maxulysse/maxulysse.github.io/main/assets/img/svg/green_white_bg.svg” –> <a href=”nf-co.re”><img src=”raw.githubusercontent.com/nf-core/logos/master/nf-core-logos/nf-core-logo-darkbg.svg” width=”60%”></img></a> # What is nf-core\? [Maxime U Garcia](https://maxulysse.github.io/) ▸ [<i class=”fa fa-twitter” aria-hidden=”true”></i>@gau](https://twitter.com/gau/) | [<i class=”fa fa-github” aria-hidden=”true”></i>@maxulysse](https://github.com/maxulysse/) [Karolinska Institutet](https://ki.se/) | [Science for Life Laboratory](https://www.scilifelab.se/) Sweden — ## Overview – 🗄️ [Barntumörbanken](https://ki.se/forskning/barntumorbanken/) – 🧬 [NGI](https://ngisweden.scilifelab.se/) – 🍬 [Nextflow](https://www.nextflow.io/) – 🧙 [nf-core](https://nf-co.re/) — ##…
Biogenesis, biology and characterization of circular RNAs
Biogenesis, biology and characterization of circular RNAs Kristensen LS et al. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. (2019) Summary text Biogenesis and properties of circRNAs Biogenesis of cirRNA Characteristics of circRNAs Discover and analyze circRNAs circRNA genome-wide analysis CircRNA site-specific analysis circRNA visualization Biological functions…
Multiplexed genome regulation in vivo with hyper-efficient Cas12a
. 2022 Apr;24(4):590-600. doi: 10.1038/s41556-022-00870-7. Epub 2022 Apr 12. Lucie Y Guo # 1 2 , Jing Bian # 3 , Alexander E Davis 4 , Pingting Liu 4 , Hannah R Kempton 3 , Xiaowei Zhang 3 , Augustine Chemparathy 3 , Baokun Gu 3 , Xueqiu Lin 3 , Draven A Rane 3 , Xiaoshu Xu 3 , Ryan M…
Characterization of mitochondrial 12S rRNA gene of yellow-striped chevrotain (Moschiola kathygre) and white-spotted chevrotain (Moschiola meminna) and development of a PCR-RFLP marker for the unambiguous identification of the species
Tragulids hold a significant place in the evolutionary history of mammals since they represent the basal branch of ruminants. Only three genera of tragulids are being extant to date such as Tragulus, Hyemoschus and Moschiola. In the genus Moschiola, Sri Lankan chevrotains (Moschiola meminna and Moschiola kathygre) are endemic to…
Production Bioinformatics Manager, Clinical Informatics (Operations)
Invitae is dedicated to bringing comprehensive genetic information into mainstream medicine to improve healthcare for billions of people. The Clinical Informatics team is driven to make a difference for the patients we serve. We are leading the transformation of the genetics industry by making genetic testing affordable and accessible for…
Metagenomi Presents Findings on Novel Families of Ultra Small, CRISPR Enzymes at the Keystone Symposia Precision Genome Engineering Conference
EMERYVILLE, Calif., May 03, 2022–(BUSINESS WIRE)–Metagenomi, a genetic medicines company with a versatile portfolio of next-generation gene editing tools, presented findings on the identification of novel families of compact, programmable enzymes for genome editing at the Keystone Symposia Precision Genome Engineering and Emerging Cellular Therapies Conference, on April 30. The…
tReasure: R-based GUI package analyzing tRNA expression profiles from small RNA sequencing data | BMC Bioinformatics
tReasure (tRNA Expression Analysis Software Utilizing R for Easy use) is a graphical user interface (GUI) tool for the analysis of tRNA expression profiles from deep-sequencing data of small RNAs (small RNA-seq) using R packages. The whole analysis workflow, including the uploading of FASTQ files of small RNA-seq, quantification of…
Team develops method to increase gene editing efficiency while minimizing DNA deletion sizes
Targeting E. coli DNA pol I to DSBs increased the ratio of 1-bp deletions versus >1-bp deletions and TIS versus non-TIS. (A) Counteracting DNA resection (e.g. MRE11) by pol I fused to Cas9. The expected result is suppression of the MMEJ and SSA DNA repair pathways, which require DNA resection. (B)…
Bioinformatics Specialist at The University of Chicago in Chicago, IL – 4091
Job Info Department BSD PED – Section Administrator: Hematology, Oncology, and Stem Cell Transplantation About the Department The Section of Pediatric Hematology/Oncology provides care for patients and families with acute and chronic medical conditions, or other hematologic diseases, requiring the specialty knowledge and skills of Hematology, Oncology and Stem Cell…
BenchSci hiring Bioinformatics Engineer (Remote) in Toronto, Ontario, Canada
BenchSci’s vision is to bring novel medicine to patients 50% faster by 2025. We’re achieving it by empowering scientists with the world’s most advanced biomedical artificial intelligence. Backed by F-Prime, Gradient Ventures (Google’s AI fund), and Inovia Capital, our platform accelerates science at 15 top-20 pharmaceutical companies and over 4,300…
Research Associate II, Bioinformatics at Sherlock Biosciences
Job details Salary $65,546 – $106,525 a year job type full-time Full job description Job description:Summary/objective: As part of this role, you will support the bioinformatics team in building a comprehensive bioinformatics software that informs the design of next generation molecular diagnosticsTogether with your mentor, you will refine and expand…
Senior Research Associate/Principal Research Associate, Bioinformatics job with Vedanta Biosciences
Title: Senior Research Associate/Principal Research Associate, Bioinformatics Location: Cambridge, MA, or up to 100% remote Reports to: Scientist I, Bioinformatics The Role: We are looking for a bioinformatician/computational biologist to support the Research and Development team in the maintenance and querying of an existing laboratory information management system (LIMS), construction…
Molecular analysis of TCGA breast cancer histologic types
Breast cancer is classified into multiple distinct histologic types, and many of the rarer types have limited characterization. Here, we extend The Cancer Genome Atlas Breast Cancer (TCGA-BRCA) dataset with additional histologic type annotations, in a total of 1063 breast cancers. We analyze this extended dataset to define transcriptomic and…
Batch-effect detection, correction and characterisation in Illumina HumanMethylation450 and MethylationEPIC BeadChip array data | Clinical Epigenetics
Experimental design and processing steps For the EpiSCOPE study [20], DHA supplementation and gender were balanced as much as possible across the 12 450K BeadChips on each glass slide, with these factors also randomly distributed over the 6 rows and 2 columns of 31 slides (Additional file 1: Fig. S1). Blood…
Mitogenome-wise codon usage pattern from comparative analysis of the first mitogenome of Blepharipa sp. (Muga uzifly) with other Oestroid flies
Outcome of DNA sequencing, assembly, and validation In this study, initially total DNA was isolated from the finely chopped, full-grown pupa of Blepharipa sp. The NanoDrop spectrophotometer (1294 ng/μl) and the Qubit fluorometer (732.8 ng/μl) both found that the concentration of total DNA in the sample at an optimum level for mitochondrial DNA enrichment. The Tape Station profile showed…
Bioinformatics Scientist in Boston, MA for Dana-Farber Cancer Institute
Details Posted: 27-Apr-22 Location: Boston, Massachusetts Salary: Open Internal Number: 2022-26921 Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to…
How can I validate the results by the software package, I have recently developed using python for genomic data?
How can I validate the results by the software package, I have recently developed using python for genomic data? 1 I have developed a software package for the analysis of genomic data, in which, I have implemented a variety of functions like normalization, clustering etc (from already available tools i.e.,…
Roche hiring Principal Bioinformatics Software Engineer, Java Development in Santa Clara, California, United States
This position may be based out of Santa Clara, California, USA, with remote work locations possible in The United States.Impact HealthcareRoche Sequencing is not only changing science, but we are changing lives. Our software teams are laying the groundwork for the future by developing powerful bioinformatics algorithms, data analysis tools,…
Postdoc Fellow on Cancer Genomics, Epigenetics, Metabolism, and Bioinformatics
Multiple postdoctoral positions are available in the lab of Dr. Jian Xu at Children’s Research Institute (CRI), UT Southwestern Medical Center to study the gene regulatory processes that control stem cell development and cancers. We employ genomics, epigenetics, genome editing, metabolomics, and mouse genetics to define disease-associated epigenetic and genetic programs…
Principal Bioinformatics Scientist I (REMOTE) job with F. Hoffmann-La Roche AG
Job Description We are seeking a committed and driven Principal Bioinformatics Scientist for our Computational Bioinformatics Research and Early Development team. We have a team of skilled bioinformatics researchers working in a highly collaborative environment with multiple internal and external teams. The work will be focused on developing novel methods…
Postdoctoral Research Fellow in Bioinformatics/Computational Biology
Details Posted: 27-Apr-22 Location: Boston, Massachusetts Salary: Open Categories: Staff/Administrative Internal Number: 2022-27118 Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with…
Bioinformatics Data Engineer in Boston, MA for Dana-Farber Cancer Institute
Details Posted: 27-Apr-22 Location: Boston, Massachusetts Salary: Open Categories: Staff/Administrative Internal Number: 2022-26005 Located in Boston and the surrounding communities, Dana-Farber Cancer Institute (DFCI) brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people…
CRISPR/Cas9 deletions induce adverse on-target genomic effects
Clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) have transformed genome engineering techniques. Numerous toolsets have been created to enable easy and efficient loss-of-function perturbations of functional genomic sites. Study: CRISPR/Cas9 deletions induce adverse on-target genomic effects leading to functional DNA in human cells. Image Credit: elenabsl/Shutterstock The CRISPR/Cas9 system’s elements…
Head of Bioinformatics job in Chesterford
Job Information Role Overview HRS are recruiting for a head of Bioinformatics to join an innovative Biotech company based in the Cambridge area. Having grown rapidly and with two oncological products progressing into clinical trials, this position will be key to maintaining the companies competitiveness, Leading a well-established team working…
Unit Manager – Bioinformatics and Genomic Epidemiology
MPHI is a Michigan-based and nationally engaged, non-profit public health institute. We are a team of teams, process and content experts, dedicated to building A world where tomorrow is healthier than today! Title: Unit Manager – Bioinformatics and Genomic Epidemiology $66,100 – $97,200 / Posted Thru: 4-28-22 Location: …
Biomedical/BioInformatics Intern in Rockville, MD
Description Job Description: The Government Health and Safety Solutions Group within the Health group has an opening for a Biomedical/Bioinformatics Intern. The intern will work alongside data scientists and managers and use biomedical or genomics data to inform health-related research questions. Primary Responsibilities: Under the guidance of Leidos staff, the…
Loyola eCommons – Undergraduate Research and Engagement Symposium: Effects of DNA looping behavior using smFRET
Anticipated Graduation Year 2022 Abstract This study developed a single-molecule-based assay to track the looping of dsDNA molecules. DNA encodes our genetic information through a combination of four nucleotides; base pairing forms dsDNA molecules in a double-helical form. The genome achieves a three-dimensional architecture; the mechanical properties of dsDNA…
Summary of Fusobacterium nucleatum MJR7757B, version 26.0
Summary of Fusobacterium nucleatum, Strain MJR7757B, version 26.0 Tier 3 Uncurated Database Summary: This Pathway/Genome Database (PGDB) was generated on 27-May-2018 from the annotated genome of Fusobacterium nucleatum MJR7757B, as obtained from RefSeq (annotation date: 04-APR-2017). The PGDB was created computationally by the PathoLogic component of the Pathway Tools software…
Bioinformatics Analyst II – Remote in Danville, PA for Geisinger
Details Posted: 22-Apr-22 Location: Danville, Pennsylvania Type: Full Time Salary: Open Categories: Operations Job Summary Primary accountability is to leverage the organization’s data assets exome sequencing data (>180,000 individuals) from MyCode Community Health Initiative to improve quality, efficiency and generate knowledge specifically in the field of bioinformatics within health research….
Bioinformatics Scientist for Whole Genome and Whole Exome Sequencing
** Bioinformatics Scientist for Whole Genome and Whole Exome Sequencing ** The NeuroGenomics and Informatics (NGI) Center lead by Dr. Carlos Cruchaga at Washington University School of Medicine is recruiting a Bioinformatics Scientist to work on Whole Genome and Whole Exome Sequencing. We are seeking an experienced, self-motivated, self-driven scientist…
Could DNA be linked to Premature Aging in Cancer Survivors?
In this interview, we speak to Dr. Zhaoming Wang about his latest research that investigated accelerated aging in childhood cancer survivors and the underlying genetics causing this. Please could you introduce yourself and tell us what inspired your latest research? I’m an associate member of the faculty at St. Jude…
Manager of Bioinformatics in Chicago, IL for University of Chicago (UC)
Details Posted: 22-Apr-22 Location: Chicago, Illinois Type: Full-time Salary: Open Categories: Research – Laboratory/Non-Laboratory Staff/Administrative Location: Hyde Park Campus Job Description: Leads a team of bioinformaticians and provides technical guidance for the team to follow best practices and deliver data production timely. Collaborates cross-functionally with our user services, software engineering,…
Endometriosis-related functional modules and hub genes
Introduction Endometriosis (EMS) is a chronic gynecological disease defined as implantation and periodic growth of the endometrial glands and stroma outside the uterine cavity, causing chronic pelvic pain, severe dysmenorrhea, and infertility in 10% reproductive-age women, among which the infertility rate is approximately 30–50%.1,2 Surgical excision is commonly used for…
Nucleic Acids Research Papers on DAVID Update, ChIP-Atlas, RNA Splicing Assay
Researchers at the Frederick National Laboratory for Cancer Research and the National Institutes of Health describe a 2021 update to the bioinformatics tool DAVID, designed for functional annotation and functional gene enrichment analyses. Along with updates to annotation types and other “Knowledgebase” features, the latest version of the DAVID Gene…
Metagenomics technology and microbial community diversity analysis methods
A large number of microorganisms in nature cannot be cultivated under laboratory conditions by pure culture methods, and the technical methods of traditional microbiology limit the research on environmental microorganisms. The rapid development of high-throughput omics technology has enabled humans to have an unprecedented understanding of the complex microbial communities…
LOC125105370 sterile alpha motif domain-containing protein 1-like [Lutra lutra (Eurasian river otter)] – Gene
The following sections contain reference sequences that belong to a specific genome build. Explain This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also…
Cytogenetics Lab Manual.pdf – Virtual Lab Manual Cytogenetics Synopsis With advances in technology, prenatal diagnosis can provide mothers-to-be with
Virtual Lab ManualCytogeneticsSynopsisWith advances in technology, prenatal diagnosis can provide mothers-to-be with information,not only about the gender of their baby, but also the physical and genetic health. Will you beable to use advanced prenatal techniques to help diagnosea fetal abnormality?Ultrasound and amniocentesisIn the Cytogenetics simulation, you will begin your mission…
Long-term artificial selection of Hanwoo (Korean) cattle left genetic signatures for the breeding traits and has altered the genomic structure
Cattle are among the largest populations of domesticated animals and used as food resources for humans; therefore, their phenotypes and genetic structure have been shaped by artificial selection for human needs and natural adaptation to environmental changes. The phenotypic selection causes genomic changes in breeding traits within breeds, resulting in…
Understanding the relationship between large-scale chromatin structure and gene expression
Abstract Eukaryotic genomes are packaged into a complex DNA, RNA, and protein rich chromatin fibre, creating an interdependent functional relationship between the structure of the chromatin and the activity of the genetic features stored within. The composition of active genomic regions is weighted towards transcription factors, co-activating proteins, and active …
RNA interference triggers that target SARS-CoV-2 genome
Coronavirus disease 2019 (COVID-19) vaccines have played a critical role in reducing transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. However, with emerging reports of waning vaccine efficacy, there remains an urgent need to develop prophylactic measures against COVID-19. In a recent study published on the bioRxiv*…
New neurodevelopmental disorder discovered
An Australian-led international research collaboration has discovered a new neurodevelopmental disorder after uncovering its link to a tumour suppressor gene, ending the diagnostic journey for 32 families around the world. Murdoch Children’s Research Institute (MCRI) researchers, along with their international peers, found variations in the FBXW7 gene were associated with…
TREEFROG THERAPEUTICS LAUNCHES A $100,000 RESEARCH GRANT IN REGENERATIVE MEDICINE
Bordeaux, France / April 19th, 2022 – TreeFrog Therapeutics, a biotechnology company aimed at making safer, more efficient and more affordable cell therapies based on induced pluripotent stem cells (iPSCs), today announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell…
Limit Fragment Duration Polymorphisms (RFLP) Style of DNA Profiling
Limit Fragment Duration Polymorphisms (RFLP) Style of DNA Profiling Conceptual The amazing strength regarding DNA technical as the a recognition product got lead a tremendous change in crimnal fairness . DNA studies legs is an information capital into forensic DNA typing neighborhood having informative data on popular quick tandem repeat…
Whole-genome analysis of coxsackievirus B3 reflects its genetic diversity in China and worldwide | Virology Journal
Song Y, Zhang Y, Han Z, Xu W, Xiao J, Wang X, et al. Genetic recombination in fast-spreading coxsackievirus A6 variants: a potential role in evolution and pathogenicity. Virus Evol. 2020;6:2. doi.org/10.1093/ve/veaa048. Article Google Scholar Chen J, Han Z, Wu H, Xu W, Yu D, Zhang Y. A large-scale outbreak…
Still doubts over embryo selection based on PGT for polygenic conditions
Advances in genomic technologies continue to expand the possibilities of PGT. In a preclinical research study recently published in Nature Medicine, scientists from Silicon Valley-based genetic testing companies have examined the potential of using PGT to predict complex polygenically inherited conditions in human embryos. While the authors present interesting data,…
Bioinformatics Scientist III – D3b at Children`s Hospital of Philadelphia
Job details Job type full-time Full job description Location: loc_roberts-roberts ctr pediatric research req id: 134035 shift: days employment status: regular – full time job summary the bioinformatics unit (bixu) within the center for data driven discovery (d3b) at the children’s hospital of philadelphia (chop) is seeking a level iii…
Understanding bioinformatics, the key to unlocking our genetic secrets
In the age of ‘Big Data’ and ‘Digital Everything’, computers, specialised software, and the Internet have become essential tools in every researcher’s toolkit to accelerate and assist in their research initiatives. In molecular biology, bioinformatics is the driving force behind the researchers’ endeavours to continue unravelling the secrets behind the…
Genomic Analysis Reveals a New Dominant Lineage of SARS-CoV-2
Scientists and health officials throughout the world are raising the alarm about the emergence and spread of more COVID variants, subvariants and third generation subvariants with the worrying mutations, which have been linked to increased fusogenicity, illness severity, and death. Infectivity and transmissibility have also grown in these new BA.2 subvariants…
Pharmacogenomics study clopidogrel by rflp based genotyping of cypc in cardiovascular disease
Volume 5 • Issue 3 • 1000132 J Pharmacogenomics Pharmacoproteomics ISSN: 2153-0645 JPP, an open access journal Research Article Open Access Prasanthi et al., J Pharmacogenomics Pharmacoproteomics 2014, 5:3 DOI: 10.4172/2153-0645.1000132 Research Article Open Access Pharmacogenomics Study of Clopidogrel by RFLP based Genotyping of CYP2C19 in Cardiovascular Disease Patients in…
CRISPRi for specific inhibition of miRNA clusters and miRNAs with high sequence homology
Bartel, D. P. MicroRNAs: Target recognition and regulatory functions. Cell 136, 215–233 (2009). CAS Article Google Scholar Bassett, A. R. et al. Understanding functional miRNA–target interactions in vivo by site-specific genome engineering. Nat. Commun. 5, 4640 (2014). ADS CAS Article Google Scholar Moore, M. J. et al. miRNA–target chimeras reveal…
aCGH – Allie: Result by abbreviation
1 array comparative genomic hybridization(1473 times) Neoplasms(306 times) FISH (238 times)CNVs (135 times)MLPA (72 times) 2003 1-Mb resolution array-based comparative genomic hybridization using a BAC clone set optimized for cancer gene analysis. 2 array CGH(43 times) Neoplasms(12 times) CNVs (7 times)FISH (3 times)ID (3 times) 2003 Combined array comparative genomic hybridization and…
Multiplexed genome regulation in vivo with hyper-efficient Cas12a,Nature Cell Biology
Multiplexed modulation of endogenous genes is crucial for sophisticated gene therapy and cell engineering. CRISPR–Cas12a systems enable versatile multiple-genomic-loci targeting by processing numerous CRISPR RNAs (crRNAs) from a single transcript; however, their low efficiency has hindered in vivo applications. Through structure-guided protein engineering, we developed a hyper-efficient Lachnospiraceae bacterium Cas12a…
Genomic Stratification of Resectable CRLM Patients & Implications for Adjuvant Therapy and Survival
For a study, the researchers sought to see if genomic risk groups discovered by colorectal liver metastasis (CRLM) somatic mutation testing may be used for “molecularly-guided” adjuvant systemic chemotherapy and hepatic artery infusion of FUDR (SYS+HAI-FUDR). A prospective institutional database was analyzed for consecutive patients with resected CRLM and available…
Postdoctoral Researcher in Genomics and Bioinformatics – Karolinska Institute – job portal
Login and apply Do you want to contribute to top quality medical research? The Department of Cell and Molecular Biology (CMB) is a department with a strong focus on basic science. CMB conducts research and education in cell biology, molecular biology, developmental biology, stem cell biology, cancer and infection biology….
Engineering and validation of a dual luciferase reporter system for quantitative and systematic assessment of regulatory sequences in Chinese hamster ovary cells
Experimental workflow and vector designs One way to validate the all-in-one reporter system is through transient or stable transfection of mammalian cells. Within this framework, the schematics in Fig. 1 illustrate the overall workflow of this study and feature the characteristics of promoters. To summarize, the study involves the engineering and…
A hypoxia-related signature in lung squamous cell carcinoma
Introduction Lung cancer is the major leading cause of tumour-related deaths throughout the world, while lung squamous cell carcinoma (LUSC) as the second most common histological type of lung cancer.1 Each year, almost 1.8 million people are diagnosed with lung cancer worldwide and 400,000 of these die from LUSC.2,3 Due to…
Pangenome-based genome inference allows efficient and accurate genotyping across a wide spectrum of variant classes
Sequencing data We used publicly available sequencing data from the GIAB consortium45, 1000 Genomes Project high-coverage data46 and Human Genome Structural Variation Consortium (HGSVC)4. All datasets include only samples consented for public dissemination of the full genomes. Statistics and reproducibility For generating the assemblies, we used all 14 samples for…
UCSC and Amazon Web Services work to accelerate genomics research
The UC Santa Cruz Genomics Institute is collaborating with Amazon Web Services (AWS) to allow researchers to quickly and efficiently execute bioinformatics pipelines on AWS’s global cloud infrastructure. AWS and UCSC are committed to accelerating genomics research by integrating the Dockstore project, a leading repository for scientific and biomedical workflows…
Sequencing 100,000 species to secure food supplies
[KAMPALA] Collecting and storing genomic information of plants, animals and other species in Africa could safeguard biodiversity and enable breeders to produce resilient and sustainable food systems, biodiversity advocates say. Under a new initiative called the African BioGenome Project (AfricaBP), they plan to collect more than 100,000 species of plants…
Pope names Nobel laureate Jennifer Doudna to Pontifical
Pope Francis appointed Dr Jennifer Doudna to the Pontifical Academy of Sciences on Wednesday. Aug 11, 2021 VATICAN: The Holy Father has appointed the distinguished Professor Jennifer Anne Doudna, , as ordinary member of the Pontifical Academy of Sciences. Professor Jennifer DoudnaProfessor Jennifer Doudna was born on 19 February 1964…
Postdoc position in phylogenomics and evolution of beetles
The research group led by Dr Dagmara Żyła at the Museum and Institute of Zoology, Polish Academy of Sciences (MIZ, PAS) is looking for candidates for a postdoc position to work within the project entitled: “The Impact of the Paleocene-Eocene Thermal Maximum on diversification dynamics in Paederinae rove beetles” funded…
Python fast way to get ONLY MAIN metadata for GSE ? (not walking through thousands underlying GSM-samples : slow or even endless)
Not Python but using EntrezDirect you can get: $ esearch -db bioproject -query “GSE118723” | esummary | xtract -pattern DocumentSummary -element Project_Description Quantification of gene expression levels at the single cell level has revealed that gene expression can vary substantially even across a population of homogeneous cells. However, it…
Map Entire Directory of Paired-End Reads at Once
Map Entire Directory of Paired-End Reads at Once 0 Is there a way to map an entire directory of reads at once? Would I just have to write a script for this specific to my directory structure and data? I’m using BWA MEM to map 49 paired-end reads and have…
Histone marks enrichment analysis
Histone marks enrichment analysis 0 Hello everyone, here’s my question: I have a bed file of human genomic coordinates (hg19), and I would like to know whether ChIP-seq peaks for specific histone marks (such as those from ENCODE) are significantly more represented within my test regions compared to a background…
Aligning 23andme to reference genome
Aligning 23andme to reference genome 0 I’ve got some 23andMe data that I’m playing around with and was wondering if the SNPs could be aligned to a reference genome to subsequently be turned into a VCF. The txt file has the genomic positions so I guess it’s possible? I just…
Variant calling from 5 MB regions coming from contrasting cultivars
Variant calling from 5 MB regions coming from contrasting cultivars 0 Hi, I would like to compare ~5 MB genomic (QTL) regions across two groups (resistant and susceptible) and identify variants that might majorly influence resistance. I was thinking of the following pipeline; use susceptible cultivar as the reference (since…
Highly used R packages with no Python equivalent
The biggies are obviously DESeq2, limma and edgeR, but they are massive packages doing some very complex statistics, and also have dependency trees that would need to be considered. Depending on your background, you might want to look into the rtracklayer/GenomicRanges eco-system. While I personally am not a fan, I…