Tag: GUIDANCE

Combining multiple 10x scRNAseq datasets

Hi everyone, Wondering if someone can provide me with some guidance. I have previously sequenced 4 skin cancers using 10X chemistries and I would like to combine them into one dataset. My research question is to look at cancer stem cell populations, so I will need sensitivity. I have done…

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Pluristyx, panCELLa, and Implant Therapeutics Announce a Strategic Alliance to Manufacture and Distribute Genetically Modified, Clinical-grade Human-induced Pluripotent Stem Cells

SEATTLE–(BUSINESS WIRE)–Pluristyx, Inc., an advanced therapy tools and services biotechnology company, panCELLa, a privately held biotechnology company, and Implant Therapeutics, a developer of genetically engineered stem cells, today announced they have entered into a manufacturing and distribution strategic alliance that offers cell therapy companies streamlined access to the next generation…

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Exact Sciences hiring Director, Bioinformatics in San Diego Metropolitan Area

Summary Of Major ResponsibilitiesThe Director, Bioinformatics is self-driven, working on multiple projects that are extremely complex in scope. As a thought leader, the Director, Bioinformatics brings their knowledge and expertise to bear in planning, design, and execution to ensure successful and timely completion of large or complex projects. The Director,…

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Sr. Manager of Manufacturing – Resumetojobs.com

NuProbe USA is seeking an experienced Sr. Manager, In-Vitro Diagnostics Operations who will be responsible for all aspects of manufacturing, including design transfer of newly developed products from research & development. The successful candidate will control production planning, scheduling and forecasting. The candidate will lead continuous improvements in manufacturing as…

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Anyone know any clever snakemake/SLURM tricks to run a big analysis with limited storage?

Anyone know any clever snakemake/SLURM tricks to run a big analysis with limited storage? 1 I am using a SLURM HPC to run jobs and have ran into issues with storage. I have 3TB storage, and want to run over 1000 publicly available RNAseq data through my pipeline, which includes…

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Cytogenomic Molecular Inversion Probe Array FFPE Tissue – Products of Conception

Cytogenetic Test Request Form Recommended (ARUP form #43098) Ordering Recommendation Recommendations when to order or not order the test. May include related or preferred tests. Use to detect copy number alterations and loss of heterozygosity in FFPE specimens from products of conception. Mnemonic Unique test identifier. CMAPFFPE Methodology Process(es) used…

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Very important pharmacogene variants in the Blang population

Introduction The use of drugs should be different among diverse ethnic groups because of differences in ethnicity, age, sex, environmental factors and genetic factors. If these differences are ignored, then drug sensitivity, metabolic rate, and adverse reactions are affected, which influences the curative effect of drugs and aggravates the illness…

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Postdoctoral Position in Structural Bioinformatics job with National Institute of Allergy and Infectious Diseases (NIAID)

  Postdoctoral Position in Structural Bioinformatics Department of Health and Human Services National Institutes of Health National Institute of Allergy and Infectious Diseases The Structural Bioinformatics Core Section (SBIS) at the National Institute of Allergy and Infectious Diseases (NIAID), Vaccine Research Center (VRC), located on the main National Institutes of…

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Fate Therapeutics Highlights Positive Durability of

6 of 10 Patients Naïve to Treatment with Autologous CAR T-cell Therapy Continue in Ongoing Response at Median Follow-up of 9.1 Months, including 4 Patients with >6 Months Follow-up, at ≥90 Million FT516 Cells per Dose 3 of 8 Patients Previously Treated with Autologous CAR T-cell Therapy Achieve Complete Response…

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Our Ability Jobs – Mayo Clinic Intern – Bioinformatics (PHD)

Why Mayo Clinic Mayo Clinic is the nation’s best hospital (U.S. News & World Report, 2020-2021) and ranked #1 in more specialties than any other care provider. We have a vast array of opportunities ranging from Nursing, Clinical, to Finance, IT, Administrative, Research and Support Services to name a few….

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Easy OpenAPI specs and Swagger UI for your Flask API

Easy Swagger UI for your Flask API Flasgger is a Flask extension to extract OpenAPI-Specification from all Flask views registered in your API. Flasgger also comes with SwaggerUI embedded so you can access localhost:5000/apidocs and visualize and interact with your API resources. Flasgger also provides validation of the incoming data,…

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Identification of Hub Genes in Patients with Alzheimer Disease and Obs

Introduction Alzheimer’s disease (AD) ranks first among the common dementia type of the world. According to epidemiological investigation from the International Alzheimer’s disease association, about 45 million people has been suffered from AD, and the number is expected to increase to 131 million in 2050.1 Despite the widespread prevalence of…

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Purifier | GENGIS KAN | Killmail

[Purifier, GENGIS KAN’s Purifier] Ballistic Control System II Ballistic Control System II Co-Processor II 5MN Y-T8 Compact Microwarpdrive Phased Scoped Target Painter Astro-Inertial Compact Missile Guidance Computer,Missile Precision Script Covert Ops Cloaking Device II Bomb Launcher I,Focused Void Bomb Polarized Torpedo Launcher,Caldari Navy Mjolnir Torpedo Polarized Torpedo Launcher,Caldari Navy Mjolnir…

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NovelStem Announces NewStem, Ltd. Was Selected by Illumina for its Global Illumina Accelerator

News and research before you hear about it on CNBC and others. Claim your 1-week free trial to StreetInsider Premium here. Boca Raton, Florida and Jerusalem, Israel–(Newsfile Corp. – September 20, 2021) – NovelStem International Corp. (OTC Pink: NSTM), a biotechnology company focused on the stem cell-based technology platform developed…

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CVC Files Opposition to ToolGen Substantive Motion No. 1 | McDonnell Boehnen Hulbert & Berghoff LLP

On July 15th, Junior Party the University of California/Berkeley, the University of Vienna, and Emmanuelle Charpentier (collectively, “CVC”) filed its Opposition to Senior Party ToolGen’s Substantive Motion No. 1 for benefit of priority to U.S. Provisional Application No. 61/837,481, filed June 20, 2013 (“P3” or “ToolGen P3”), or alternatively, International…

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Why do non-smokers develop lung cancer? Healing practice

Why do people who have never smoked get lung cancer? In recent research, three subtypes of lung cancer were classified by non-smokers. (Photo: utah51/stock.adobe.com) Analysis: Lung cancer in non-smokers Even if smoking is the main risk factor for developing lung cancer, it is not uncommon for people who have never…

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gmod advanced duplicator 2

Advanced Duplicator 2 is a Garry’s Mod addon which implements a tool similar to the Duplicator, but with many added features. Yeah no problem mate, thanks for the response. I’m done with gmod and I don’t take requests, so please stop spamming the comment section. “Originally published in single magazine…

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Senior Bioinformatics Engineer | United States

Natera™ is a global leader in cell-free DNA (cfDNA) testing with a focus on women’s health, oncology, and organ health. To bolster our oncology products, we are looking for a Senior Bioinformatics Engineer to provide technical leadership and process guidance. Through collaboration between the product and development teams, the Senior…

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Determining up-regulation vs down-regulation DESeq2 likelihood ratio test

Determining up-regulation vs down-regulation DESeq2 likelihood ratio test 0 Hello, I am hoping to receive some guidance on interpreting an RNA-sequencing project I am conducting. For this project, I have 9 time points, 3 biological replicates per time point, and 2 genotypes: wildtype vs mutant. I am using a likelihood…

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Beyond Ventures’ first investment, Prenetics, becomes first Hong Kong unicorn to go public

HONG KONG, Sept. 16, 2021 /PRNewswire/ — Hong Kong-based venture capital firm Beyond Ventures is pleased to support today’s announcement by the firm’s first investee company, Prenetics, that Prenetics, a global leader in genomic and diagnostic testing is set to merge with Artisan Acquisition Corp. (Nasdaq: ARTAU, “Artisan”), to become…

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FTC to take on Trump’s vertical merger guidelines

With help from John Hendel and Leah Nylen — Agency agenda: The FTC plans to rescind Trump-era vertical merger guidelines at today’s open meeting. But how much will that really change? — Broadband moves: As House committees wrap up their portions of Democrats’ social spending package , some lawmakers are…

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Liftover nonmodel VCF

Liftover nonmodel VCF 1 Hi all, I have a FASTA genome assembly and a VCF for my (nonmodel) study species. Now I want to liftover the VCF to the Zebra Finch genome (www.ncbi.nlm.nih.gov/assembly/GCF_003957565.1). I’ve found Picard LiftOver GATK and CrossMap, but both require a UCSC chain file, which apparently can…

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Difficulty installing Bioperl for use with GUIDANCE

Difficulty installing Bioperl for use with GUIDANCE 0 Hi, I am trying to use the Guidance software to analyze a set of 427 sequences. I have the software downloaded and installed the modules indicated in the Guidance user guide (Perl/BioPerl/Ruby), but when I attempt to run Guidance with the following…

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Regarding Error query

My name is Ruddhida Vidwans, I am a Ph.D. Research Scholar at Jain University, Bengaluru, India. My research area is Forensic Microbiology. Currently, apart from my Ph.D., I am focussing on learning next-generation sequencing analysis. For that, I am practicing with the publicly available data. I am using the “GSE163207”…

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New research provides an additional overview of optimistic reasons related to heart regeneration

CRISPR / Cas9 Wls knockdown in cardiomyocytes promotes cardiac fibroblast proliferation during neonatal cardiac regeneration. Green indicates vimentin-positive cardiac fibroblasts. Red indicates cells that are proliferating with the EdU label. Blue indicates nuclei with DAPI staining. Credit: Texas Heart Institute Texas Heart Institute has new research from its abundant cardiomyocyte…

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Bioinformatics Software Engineer I – Memorial Sloan Kettering Cancer Center

At Memorial Sloan Kettering (MSK), we’re not only changing the way we treat cancer, but also the way the world thinks about it. By working together and pushing forward with innovation and discovery, we’re driving excellence and improving outcomes.  We’re treating cancer, one patient at a time. Join us and make a…

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The CRISPR Family Tree Holds a Multitude of Untapped Gene Editing Tools

Thanks to CRISPR, gene therapy and “designer babies” are now a reality. The gene editing Swiss army knife is one of the most impactful biomedical discoveries of the last decade. Now a new study suggests we’ve just begun dipping our toes into the CRISPR pond. CRISPR-Cas9 comes from lowly origins….

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Exact Sciences and National Surgical Adjuvant Breast and Bowel Project Announce Clinical Validation Study to Detect Minimal Residual Disease in Colorectal Cancer Patients

“Our longstanding relationship with the NSABP, through our work to develop and validate the Oncotype DX Breast Recurrence Score® and Colon Recurrence Score® tests, represents a remarkable collaboration between academic and industry partners. This relationship has fueled major advancements in understanding the role of molecular profiling in breast and colon…

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Senior Research Associate (Lab Operations)

Senior Research Associate (Lab Operations) – 93657 Organization: BS-BioSciences Area Office Lawrence Berkeley National Lab’s (LBNL, www.lbl.gov/), Biosciences Area Office (biosciences.lbl.gov/) has an opening for a Senior Research Associate (Lab Operations). The Senior Associate will perform various tasks to assist the Emery Station East (ESE) Director of Laboratory Operations to…

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Career counselling: questions and answers

Q1: Sir, I am a regular reader of your column in The News. My son obtained 82% marks in first year FSc (Pre-Engg). However, he is not interested in the engineering field and intends to take admission in BS Economics & Data Science. Please advise me about this subject, whether…

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Oxford Nanopore Stock: The Internet of Living Things

If you took all the stocks in the world and put them in a single basket, about 58% of that combined market cap would be U.S. stocks. If you want to look that number up, just download a fact sheet for the MSCI ACWI IMI Index. All those cryptic acronyms…

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Trove of CRISPR-like gene-cutting enzymes found in microbes

The Cas9 enzyme — known as CRISPR’s molecular scissors — is used to find and cut specific DNA sequences.Credit: Nature By exploring the evolutionary origins of an enzyme used in the CRISPR genome-editing system, researchers have unearthed more than one million other potential editors lurking in microbial genomes. The study,…

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FTC tees up withdrawing vertical merger guidelines | Article

The agenda for the agency’s Sept. 15 meeting includes an item proposing withdrawal of the guidelines adopted in June 2020, as well as commentary on vertical merger enforcement issued in December 2020. The guidelines were jointly proposed in January 2020 by the FTC and Department of Justice’s Antitrust Division and…

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Cancer Mutation Detection Depends on Choices at Each Step of Sequencing, Analysis Pipeline

NEW YORK — An international team of researchers has examined how variations in sequencing approaches can influence the ability to accurately detect cancer mutations, providing guidance for the wider community. The team additionally developed a set of reference samples for benchmarking efforts. Next-generation sequencing approaches are increasingly being adopted to…

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The 10 Best Tableau Tutorials on YouTube to Watch Right Now

This list of the best Tableau tutorials on YouTube will introduce you to one of the most popular analytics and business intelligence platforms. Tableau is one of the most widely used business intelligence and data analytics platforms in the world. It features powerful data discovery and exploration capabilities that allow…

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What are DNA Mixtures?

Matching DNA evidence to a suspect can be a huge breakthrough in court cases and forensic investigations. Historically, DNA evidence was extracted from relatively simple samples with a high DNA load, such as blood stains or hair strands. Image Credit: anyaivanova/Shutterstock.com Over time, DNA sequencing technology has advanced to allow…

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28 Best Universities for Masters in Bioinformatics in UK

Bioinformatics has always been a critical field in the biomedical science domain for the last two decades. At present, bioinformatics has become a key component in personalized medicine along with vital applications in basic & translational research and the development of new diagnostic & therapeutic tools. The UK has been…

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ToolGen Files Opposition to CVC Contingent Responsive Preliminary Motion No. 1 | McDonnell Boehnen Hulbert & Berghoff LLP

On June 11th, Junior Party the University of California, Berkeley; the University of Vienna; and Emmanuelle Charpentier (collectively, “CVC”) filed its Responsive Preliminary Motion No. 1 in Interference No. 106,127 to be accorded benefit of priority to U.S. Patent Application No. 13/842,859, filed March 15, 2013, or in the alternative…

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Biologist Bioinformatics Server Administration Job in CLAY CENTER, NE

Overview Open & closing dates Opening and closing dates 09/02/2021 to 09/16/2021 Service Competitive Pay scale & grade GS 9 – 11 Salary $53,433 to $84,049 per year Appointment type Permanent Work schedule Full-time Locations 1 vacancy in the following location: Relocation expenses reimbursed No Telework eligible Yes as determined…

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Bioinformatics Core Capability Lead job with Animal and Plant Health Agency

Bioinformatics Core Capability Lead Department of Bacteriology, Animal & Plant Health Agency (APHA) New Haw, South East The Animal and Plant Health Agency (APHA) is an Executive Agency of the Department for Environment, Food & Rural Affairs, and works on behalf of the Scottish Government and Welsh Government. Our diverse…

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Biologist (Bioinformatics) – USDA Employment

Job Description: This position is located within United States Department of Agriculture, Agricultural Research Service, ARS Field Organization, Northeast Area, Eastern Regional Research Center, Dairy and Functional Foods Research Service in Wyndmoor, PA. The incumbent works as part of a scientific team, providing bioinformatics resource pertaining to metagenomics, metabolomics, and…

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Veterinary students explore research careers in summer program | VTx

Emma Loessberg of Richmond, Virginia, is a second-year veterinary student at the college. She is pursuing a career in pathology research, and the program was a great fit for her goals. “I hoped this program would help fill in the gaps when it came to my laboratory experience. I was…

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CRISPR Applications in Medicine Depend on Minimizing Off-Target Editing

By Rolf Turk, PhD Genome editing technologies, such as CRISPR, are being applied to better understand basic biological systems as well as to research new kinds of gene and cell therapies. The CRISPR-Cas9 system comprises a Cas9 endonuclease protein that forms a complex with a guide RNA (gRNA) molecule, which…

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Bioinformatics AMD Manager | Government Jobs

Effective date: June 29, 2021 Contents 1.Introduction 2.About this Policy 3.Information We Collect About You 4.Our Use of Your Information 5.Information We Disclose 6.Your Data Rights 7.Retention and Removal 8.Cookies and similar Tracking Technologies; “Do Not Track” 9.Information Security and Integrity 10.Information on Children 11.Your California Privacy Rights 12.Your Nevada…

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Sr Bioinformatics Research Scientist- Pediatric Cancer Genome Data Cloud job with St. Jude Children’s Research Hospital

Overview The department of Computational Biology is seeking a highly motivated Sr. Bioinformatics Research Scientist to serve as the scientific lead for St. Jude Cloud, a cloud-based ecosystem for data sharing, cloud-computing and dynamic visualization of the world’s largest pediatric cancer genomic data set. The candidate will be a part of an interdisciplinary…

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Senior Research Associate in Bioinformatics job with University of Bristol

The role We are looking for an experienced bioinformatician to provide support for academic users of the University of Bristol Genomics facility and to teach on our Bioinformatics Masters course. What will you be doing? The role holder will be working as part of the Genomics Facility team, a core…

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Focal therapy for localised prostate cancer

By Kalli Spencer The main goal of focal therapy is the targeted focal destruction of cancer tissue with the preservation of surrounding healthy prostate tissue. There have been conflicting opinions on the definition, but it seems the consensus is “ablation of the dominant or index lesion”1. The principle of targeted…

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Graduate/PhD Student Computational Biology/Bioinformatics, Berlin Institute of Health, Germany

Job:Graduate/PhD Student Computational Biology/Bioinformatics, Berlin Institute of Health, Germany 0 The Berlin Institute of Health (BIH) JRG Computational Genome Biology is looking for a PhD Student Computational Biology / Bioinformatics (m/f/d) (fulltime) to fill a three year appointment (earliest start Nov 1st, 2021). The bioinformatics group “Computational Genome Biology” of…

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Bioinformatics Analyst II in Danville, PA for Geisinger

Job Summary Primary accountability is to leverage the organization’s data assets exome sequencing data (>180,000 individuals) from MyCode Community Health Initiative to improve quality, efficiency and generate knowledge specifically in the field of bioinformatics within health research. Performs and supervises complex data extraction, transformation, visualization, and summarization to support Research…

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Bioinformatics Analyst in Pittsburgh, PA

Description Purpose: The UPMC Genome Center is a clinical grade, full-service, high-throughput genome center with sequencing options designed for both clinical and research needs. We are looking for members to join our Bioinformatics team for analysis of a wide spectrum (Whole Exome/Genome Germline and Somatic, RNAseq, scRNAseq) of NGS data…

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gatk, ref and alt percentages .

gatk, ref and alt percentages . 0 Hello everyone, I need some info regarding how to get percentage of REF and ALT nucleotide sequence in my data. I am using gatk and currently not getting REF and ALT percentages . the command i am using for the gatk vcf file…

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Sr Research Associate II, Biologics Analytical Operations job with Gilead Sciences, Inc.

Sr Research Associate II, Biologics Analytical OperationsUnited States – California – Oceanside Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living…

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Bioinformatician — Biological data and network analysis

  EMBL is seeking to recruit a service Bioinformatician/data scientist at EMBL Heidelberg. The position is available in the group of Peer Bork, and will be integrated in the upcoming data science center at EMBL-Heidelberg from 2022 onwards. The successful candidate will be responsible for disseminating expertise, know-how, and guidance…

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DAPARS2 generate region annotation output bed’s size is 0

DAPARS2 generate region annotation output bed’s size is 0 0 hello everyone, I want to generate region annotation using dapars2, but the output bed file’s size is zero, the bed file from the test data provided by dapars2 is also zero, the same as my data’s . Total extracted 3’…

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Biologist Bioinformatics Job in GLENSIDE, PA

Overview Open & closing dates Opening and closing dates 08/16/2021 to 09/16/2021 Service Competitive Pay scale & grade GS 12 – 13 Salary $84,231 to $130,211 per year Appointment type Permanent Work schedule Full-time Locations 1 vacancy in the following location: Relocation expenses reimbursed No Telework eligible Yes as determined…

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terminal can’t activate base automatically (conda)

terminal can’t activate base automatically (conda) 0 hello everyone, the base suddenly can‘t be activated automatically when I start terminal, it can work before. I have to type bash to activate base now. I have tried conda config –set changeps1 true conda config –set auto_activate_base true but they didn’t work…

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Integrated DNA Technologies hiring Bioinformatics Intern in Coralville, Iowa, United States

IDT is the leading manufacturer of custom oligonucleotides and proprietary technologies for genomics applications. Our work is complex and cutting-edge, and our team members are curious, creative thinkers who understand that good data drives smart decisions. At IDT, we realize that although science may be uniform, people are unique. We…

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Filtering lowly expressed genes

Hello all, I have a quick RNAseq (Quantseq) question for you all! I am analyzing the Quantseq data for 500 patients and am finding my way through the bioinformatic forest. Currently I am working on a way to filter out lowly expressed genes, and I am using the Bioconductor package…

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Chipseq visualization how to draw the figure

Chipseq visualization how to draw the figure 1 Dose anybody know how to draw the figure using Chpseq data? Any guidance would be appreciated ! (the figure is from The Histone Lysine Demethylase JMJD3/KDM6B Is Recruited to p53 Bound Promoters and Enhancer Elements in a p53 Dependent Manner) peaks Chipseq…

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Analyzing TCRseq Data

Analyzing TCRseq Data 1 Hi everyone, I am new to TCRseq and I have some data that I would like to start analyzing. I was hoping I can get people’s input on what the best package to analyze the 10x V(D)J output would be. I am currently debating between immunarch…

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Aligning 23andme to reference genome

Aligning 23andme to reference genome 0 I’ve got some 23andMe data that I’m playing around with and was wondering if the SNPs could be aligned to a reference genome to subsequently be turned into a VCF. The txt file has the genomic positions so I guess it’s possible? I just…

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