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Tag: H358
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
KRAS mutations are among the most frequent gain-of-function alterations found in patients with cancer and their therapeutic targeting has long been a key objective in precision oncology8,9,10,11,12. The KRAS GTPase cycles between an active (GTP-bound) and an inactive (GDP-bound) state. GTP hydrolysis is enhanced by GTPase-activating proteins13, whereas GDP to…
GlaI cleavage assistant isothermal exponential amplification coupling with CRISPR/Cas12a for ultrasensitive detection of CLDN11 methylation: a potential marker for lung adenocarcinoma,Sensors and Actuators B: Chemical
DNA methylation is closely associated with cancer, and sensitive detection of DNA methylation is immensely significant for early cancer screening. In this study, for the first time, we identified CLDN11 methylation as a valuable marker for lung adenocarcinoma diagnosis and prognosis based on database analysis and experimental verification using clinical…