Tag: H3K9me3

Differential enrichment of H3K9me3 in intrahepatic cholangiocarcinoma | BMC Medical Genomics

Sia D, Tovar V, Moeini A, Llovet JM. Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies. Oncogene. 2013;32(41):4861–70. CAS  Article  Google Scholar  Sungwan P, Lert-Itthiporn W, Silsirivanit A, Klinhom-On N, Okada S, Wongkham S, Seubwai W. Bioinformatics analysis identified CDC20 as a potential drug target for cholangiocarcinoma. PeerJ. 2021;9:e11067. Article …

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Allele-specific H3K9me3 and DNA methylation co-marked CpG-rich regions serve as potential imprinting control regions in pre-implantation embryo

. 2022 May;24(5):783-792. doi: 10.1038/s41556-022-00900-4. Epub 2022 Apr 28. Affiliations Expand Affiliations 1 Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China. 2 Shanghai Institute of Stem…

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Figure – PMC

Early-life FGF2 alters the association of H3K9me3 at FGF2 and GR promoters. (A and B) The association of H3K9me3 at FGF2 decreased significantly in HC and NAcc bLR rats following neonatal FGF2 exposure (***P < 0.001, n = 6 per group). (A and C) However, the association of H3K9me3 at…

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Single-Cell Technology Measures Epigenetic States and Gene Expression in One Go

Advances in single-cell technologies have not only made it possible to analyze multiple molecular families in individual cells, they have also enabled scientists to parse through limitations in data analysis arising from the intercellular diversity of measured parameters. Although single-cell sequencing is now widely available, techniques to detect epigenetic markers…

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A new technique to unravel gene regulation

Zebrafish notochord nuclei at 15-somite stage. Grey: nuclear DNA (DAPI). Color: histone H3K9me3. Credit: Phong Nguyen, Franka Rang & Kim de Luca. How is the activity of genes regulated by the packaging of DNA? To answer this question, a technique to measure both gene expression and DNA packaging at the…

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ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses

Key Points ATF7ip is a critical regulator of CD8+ T cell effector and memory responses. Deletion of ATF7ip in CD8+ T cells results in enhanced Il2 and Il7r expression. ATF7ip targets transposable elements to modulate Il7r and Il2 expression. Abstract CD8+ T cells are critical for the immune response to…

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SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers

. 2022 Jan 17;S1097-2765(21)01142-4. doi: 10.1016/j.molcel.2021.12.037. Online ahead of print. Affiliations Expand Affiliations 1 DNA Repeat Lab, Institute of Human Genetics CNRS-Université de Montpellier UMR 9002, 141 rue de la Cardonille, 34000 Montpellier, France. 2 Chromatin and Cell Biology Lab, Institute of Human Genetics CNRS-Université de Montpellier UMR 9002, 141…

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Lead exposure induces dysregulation of constitutive heterochromatin hallmarks in live cells

This article was originally published here Curr Res Toxicol. 2021 Dec 11;3:100061. doi: 10.1016/j.crtox.2021.12.001. eCollection 2022. ABSTRACT Lead (Pb) is a heavy metal contaminant commonly found in air, soil, and drinking water due to legacy uses. Excretion of ingested Pb can result in extensive kidney damages due to elevated oxidative…

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Exercise Reduces H3K9me3 and Regulates Brain Derived Neurotrophic Factor and GABRA2 in an Age Dependent Manner

FIGURE 6 H3K9me3 repression of BDNF and GABA receptors decreases with age. Comparison of ChIP%… FIGURE 6 H3K9me3 repression of BDNF and GABA receptors decreases with age. Comparison of ChIP% input data from young and aged mice. (A) H3K9me3 levels at the BDNF 1 promoter were significantly greater in young…

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Figure 5 | One-Two Punch Therapy for the Treatment of T-Cell Malignancies Involving p53-Dependent Cellular Senescence

Wogonin induced senescence-associated heterochromatin foci in senescent cells. (a) Hut-102 and Jurkat cells were treated with or without 20 μM wogonin for 5 d; then, the cells were fixed and permeabilized, and nuclei were stained with DAPI (blue). SAHF formed in wogonin-treated Hut-102 and Jurkat cells. Representative confocal images for wogonin-induced SAHF…

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Early male and female germ cells regulate their gene expression differently

13 December 2021 Gene expression during early development of primordial germ cells (PGCs) is sex-specific. Research led by Professor Petra Hajkova from the Reprogramming and Chromatin research group at the Medical Research Council London Institute of Medical Sciences has shown for the first time that germ cells, which give rise…

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