Tag: HCC

Immune Infiltration and N(6)-Methyladenosine ncRNA Isoform Detection in Acute Lung Injury

Acute lung injury (ALI) is a severe form of sepsis that is associated with a high rate of morbidity and death in critically ill individuals. The emergence of ALI is the result of several factors at work. Case mortality rates might range from 40% to 70%. Researchers have discovered that…

Continue Reading Immune Infiltration and N(6)-Methyladenosine ncRNA Isoform Detection in Acute Lung Injury

Spatiotemporal modulation of SMAD4 by HBx is required for cellular proliferation in hepatitis B-related liver cancer

Purpose: Hepatitis B virus (HBV) plays a crucial role in the progression of hepatocellular carcinoma (HCC). It is known that HBV-encoded X protein (HBx) can induce genetic alterations in some oncogenes and that SMAD4 is relevant for the development of some cancers, especially HBV-related HCC. Previously, it has been reported…

Continue Reading Spatiotemporal modulation of SMAD4 by HBx is required for cellular proliferation in hepatitis B-related liver cancer

Roles of circRNAs | CMAR

Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with an increasing global incidence, and a leading cause of cancer-related mortality.1 Although hepatitis B and C virus infections, cirrhosis, alcohol intake, and non-alcoholic fatty liver disease (NAFLD) are the main risk factors contributing to HCC.1,2 Approximately…

Continue Reading Roles of circRNAs | CMAR

Genome Editing Market Size Value US$ 16.98 billion by 2028; grow at a CAGR of 18.4%

According to our new research study on “Genome Editing Market Forecast to 2028 – COVID-19 Impact and Global Analysis – by Technology, Application, and End User,” the market is expected to grow from US$ 5.19 billion in 2021 to US$ 16.98 billion by 2028; it is estimated to grow at…

Continue Reading Genome Editing Market Size Value US$ 16.98 billion by 2028; grow at a CAGR of 18.4%

aCGH – Allie: Result by abbreviation

1  array comparative genomic hybridization(1473 times) Neoplasms(306 times) FISH (238 times)CNVs (135 times)MLPA (72 times) 2003 1-Mb resolution array-based comparative genomic hybridization using a BAC clone set optimized for cancer gene analysis. 2  array CGH(43 times) Neoplasms(12 times) CNVs (7 times)FISH (3 times)ID (3 times) 2003 Combined array comparative genomic hybridization and…

Continue Reading aCGH – Allie: Result by abbreviation

circRNA rtcisE2F regulates the self-renewal o

image: rt-circRNA rtcisE2F is originated from two adjacent genes CYP2C18 and CYP2C19, involves in the binding between m6A E2F6/E2F3 mRNAs and m6A readers IGF2BP2/YTHDF2, and finally promotes the stability of E2F6/E2F3 mRNAs. E2F6 and E2F3 drive the activation of Wnt/β-catenin signaling and the self-renewal of liver TICs. view more  Credit: ©Science…

Continue Reading circRNA rtcisE2F regulates the self-renewal o

Genetic variants of XRCC1 and risk of hepatocellular carcinoma in chronic hepatitis C patients: British Journal of Biomedical Science: Vol 76, No 2

ABSTRACT Background: Hepatitis C virus (HCV) related liver cirrhosis occurs in about 20% of chronically infected patients over a duration of 10–20 years, and within 5 years approximately 10–20% of these cirrhotic patients will develop hepatocellular carcinoma (HCC). Previous studies report that the X-ray repair cross-complementing group1 gene (XRCC1) is…

Continue Reading Genetic variants of XRCC1 and risk of hepatocellular carcinoma in chronic hepatitis C patients: British Journal of Biomedical Science: Vol 76, No 2

Image2_Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma.TIF

Background: Circular RNAs (circRNAs) have been demonstrated to be closely related to the carcinogenesis of human cancer in recent years. However, the molecular mechanism of circRNAs in the pathogenesis of hepatocellular carcinoma (HCC) has not been fully elucidated. We aimed to identify critical circRNAs and explore their potential regulatory network…

Continue Reading Image2_Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma.TIF

Adrenal aldosterone-producing adenoma | IJGM

Background Primary hyperaldosteronism (PA) is characterized by spontaneous secretion of excessive aldosterone and inhibition of plasma renin activity.1 The pathogenesis of adrenal aldosterone-producing adenoma (APA) involves the abnormal proliferation of adrenal cortex cells and the excessive secretion of aldosterone, accounting for nearly 30% of PA. Excessive secretion of aldosterone can…

Continue Reading Adrenal aldosterone-producing adenoma | IJGM

Dec 10 | CS Colloquium Series: “Multi-scale Data Integration and Causal Inference for Biological and Medical …

Event listing from University of Pittsburgh: Friday, December 10 from 2:00 PM to 3:00 PM Abstract: The advancement of technologies for high-throughput collection of personal data, including environmental, lifestyle, clinical and biomedical data, has inadvertently transformed biology and medicine. Integrating and co-analyzing these different data streams has become the research…

Continue Reading Dec 10 | CS Colloquium Series: “Multi-scale Data Integration and Causal Inference for Biological and Medical …

Prognosis Biomarkers via WGCNA in HCC

Introduction According to the cancer statistics reported in 2020, hepatocellular carcinoma (HCC) is the main type of Primary Carcinoma of the Liver and the second leading causes of cancer-related death globally, with a five-year survival rate < 20%.1 Currently, surgical resection, a standard therapy for HCC, contributes to the prognosis…

Continue Reading Prognosis Biomarkers via WGCNA in HCC

Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for rapid, accurate, and affordable somatic mutation detection | Genome Biology

Stochastic Amplicon Ligation. DNA samples for oncology sequencing are typically extracted from FFPE tissues and can have average lengths of less than 500 nt due to accumulated chemical damage [18]. We developed the Stochastic Amplicon Ligation (SAL) method to enzymatically concatenate many short DNA molecules together to utilize the long-read…

Continue Reading Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for rapid, accurate, and affordable somatic mutation detection | Genome Biology

Science Papers Uncover Protein Involved in Tumor Metastasis, Cancer Detection Via DNA Methylation Sequencing

Using a temporal multi-omics approach, a team led by scientists from Heidelberg University has identified a protein involved in tumor metastasis that could serve as a new therapeutic cancer target. Metastasis is the leading cause of cancer-related mortality and the mechanistically least well-understood step of the tumor progression cascade. However,…

Continue Reading Science Papers Uncover Protein Involved in Tumor Metastasis, Cancer Detection Via DNA Methylation Sequencing

Single cell DNA sequencing reveals punctuated and gradual clonal evolution in hepatocellular carcinoma

Footnotes Grant support This work is jointly supported by National Natural Science Foundation of China (82173035, 81802813,82030079, 81972656, 81988101, and 81902401), the National Science and Technology Major Project of China (2018ZX10723204), the Michigan Medicine and Peking University Health Science Center Joint Institute for Translational and Clinical Research (BMU2020JI005), Natural Science…

Continue Reading Single cell DNA sequencing reveals punctuated and gradual clonal evolution in hepatocellular carcinoma

Modification of endoglin-targeting nanoliposomes | IJN

Introduction Today, malignant tumors (cancer) still severely imperil human health and cause millions of global mortality rates.1,2 Deep-seated solid tumors are challenging to cure by most therapeutic tools, mainly blamed on the complex tumor microenvironment (TME).3,4 Adoptive cell therapy (ACT), as one of the effective immunotherapeutic means for cancer treatment,…

Continue Reading Modification of endoglin-targeting nanoliposomes | IJN