Tag: hiPSCs

Faculty Opinions: hiPSCs for predictive modelling of neurodegenerative diseases: dreaming the possible.

Rivetti di Val Cervo P et al. Nature Reviews. Neurology. 2021 06; 17(6):381-392 doi.org/10.1038/s41582-021-00465-0PMID: 33658662 Show Details AbstractAuthors Human induced pluripotent stem cells (hiPSCs) were first generated in 2007, but the full translational potential of this valuable tool has yet to be realized. The potential applications of hiPSCs are especially…

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TF differentiation of hiPSCs at Wellcome Sanger Institute

Salary per annum: c.£33,900 Contract Length: 2 years Here at the world-famous and internationally respected Wellcome Sanger Institute, we have an exciting opportunity for a postdoctoral researcher to perform high throughput screening for transcription factor-driven differentiation in human pluripotent stem cells (hiPSCs) in order to create better in vitro differentiated cells that more faithfully…

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Nanofountain Probe Electroporation system enables efficient engineering of stem cells — ScienceDaily

One of the ultimate goals of medical science is to develop personalized disease diagnostics and therapeutics. With a patient’s genetic information, doctors could tailor treatments to individuals, leading to safer and more effective care. Recent work from a team of Northwestern Engineering researchers has moved the field closer to realizing…

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Human induced pluripotent stem cells improve visual acuity, vascular health — ScienceDaily

Researchers at Indiana University School of Medicine, in collaboration with the University of Alabama at Birmingham and five other institutions, are investigating novel regenerative medicine approaches to better manage vascular health complications from type 2 diabetes that could someday support blood vessel repair in the eye among diabetic patients with…

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Connecting science to medicine: tendon-like t

image: (a) Comparison of bio-tendons generated from GFP-iPSC-MSCs and Mkx-iPSC-MSCs. (b) SEM images of the surface layer of GFP-bio-tendon and Mkx-bio-tendon. view more  Credit: Department of Systems BioMedicine, TMDU Researchers from Tokyo Medical and Dental (TMDU) develop artificial tendons in vitro from human stem cells that could fix common tendon injuries…

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SUMO and stem cells

Stem cells are like master cells — they can divide to create more stem cells and be triggered by signals within and outside of themselves to give rise to virtually any cell type in the body. In order to exist as precursors, in what is called the pluripotent state, stem…

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Multi-organoid system to simulate human liver

image: Enlarged view of the co-culture system view more  Credit: Advanced Science Type 2 diabetes (T2DM) is a systematic multi-organ metabolic disease, which is characterized by dynamic interplay among different organs. Pancreatic islet-liver axis is closely associated with normal glucose regulation and homeostasis maintenance. The dysfunction of the interplay between these…

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Multi-organoid system to simulate human liver-islet axis in normal and type 2 diabetes

Schematic of hiPSCs derived multi-organoid-on-chip system to model human liver-pancreatic islet axis in vitro. Credit: Tao Tingting Type 2 diabetes (T2DM) is a systematic multi-organ metabolic disease, which is characterized by dynamic interplay among different organs. Pancreatic islet-liver axis is closely associated with normal glucose regulation and homeostasis maintenance. The…

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River BioMedics Raises Seed Investment to Progress its Cardiovascular Disease Programs

River BioMedics Raises Seed Investment to Progress its Cardiovascular Disease Programs • Eur 1.8 million seed funding to progress its pipeline of cardiovascular disease targets • Company appoints Nicky Cooper as its Chief Executive Officer • Financing round co-led by FIRST Fund, KIKK Capital and Oost NL Enschede, The Netherlands,…

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Functioning induced liver cells from skin tissue

Figure 1. Urea metabolism is impaired in patient-derived human-induced pluripotent stem cells (hiPSCs) differentiated into hepatocytes (hiPSC-Heps). (A) Scheme showing the urea cycle detoxifying ammonia (NH4+) into nontoxic urea in five consecutive urea cycle enzyme (UCE)–mediated reactions in mitochondria in hepatocytes. (B) Urea secretion in four control hiPSC-Hep lines (Ctrl_1-4)…

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Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients

Figure 6 Dynamics of pluripotent and germ cells markers during hPGCLCs -TS induction. ( A… Figure 6 Dynamics of pluripotent and germ cells markers during hPGCLCs -TS induction. (A) Schematic protocol used to generate hPGCLCs. (B) hiPSCs-TS (p20), hEpiLC-TS (D.2), and hPGCLCs-TS (D.6) quantification of the relative expression of OCT4,…

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An Optimized Culture Medium for Induced Pluripotent Stem Cells

In 2006, Kazutoshi Takahashi and Shinya Yamanaka made a revolutionary breakthrough when they reprogrammed terminally differentiated, lineage-restricted adult somatic cells into a pluripotent state via the expression of transcription factors Oct4, Sox2, Klf4, and c-Myc.1 Now, researchers can differentiate reprogrammed induced pluripotent stem cells (iPSCs) into any cell type and…

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Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant

Abstract With the wide adoption of genomic sequencing in children having seizures, an increasing number of SCN2A genetic variants have been revealed as genetic causes of epilepsy. Voltage-gated sodium channel Nav1.2, encoded by gene SCN2A, is predominantly expressed in the pyramidal excitatory neurons and supports action potential (AP) firing. One…

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Scientific webinars on SelectScience

Genome engineering has revolutionized medical research through the ability to precisely edit the DNA sequence of cells. In combination with human induced pluripotent stem cells (hiPSCs), editing the genome can provide unprecedented insight into disease-causing mechanisms on a patient and tissue-specific basis. A major challenge, however, is the efficient generation…

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