Tag: hiPSCs

Multi-organoid system to simulate human liver-islet axis in normal and type 2 diabetes

Schematic of hiPSCs derived multi-organoid-on-chip system to model human liver-pancreatic islet axis in vitro. Credit: Tao Tingting Type 2 diabetes (T2DM) is a systematic multi-organ metabolic disease, which is characterized by dynamic interplay among different organs. Pancreatic islet-liver axis is closely associated with normal glucose regulation and homeostasis maintenance. The…

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River BioMedics Raises Seed Investment to Progress its Cardiovascular Disease Programs

River BioMedics Raises Seed Investment to Progress its Cardiovascular Disease Programs • Eur 1.8 million seed funding to progress its pipeline of cardiovascular disease targets • Company appoints Nicky Cooper as its Chief Executive Officer • Financing round co-led by FIRST Fund, KIKK Capital and Oost NL Enschede, The Netherlands,…

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Functioning induced liver cells from skin tissue

Figure 1. Urea metabolism is impaired in patient-derived human-induced pluripotent stem cells (hiPSCs) differentiated into hepatocytes (hiPSC-Heps). (A) Scheme showing the urea cycle detoxifying ammonia (NH4+) into nontoxic urea in five consecutive urea cycle enzyme (UCE)–mediated reactions in mitochondria in hepatocytes. (B) Urea secretion in four control hiPSC-Hep lines (Ctrl_1-4)…

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Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients

Figure 6 Dynamics of pluripotent and germ cells markers during hPGCLCs -TS induction. ( A… Figure 6 Dynamics of pluripotent and germ cells markers during hPGCLCs -TS induction. (A) Schematic protocol used to generate hPGCLCs. (B) hiPSCs-TS (p20), hEpiLC-TS (D.2), and hPGCLCs-TS (D.6) quantification of the relative expression of OCT4,…

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An Optimized Culture Medium for Induced Pluripotent Stem Cells

In 2006, Kazutoshi Takahashi and Shinya Yamanaka made a revolutionary breakthrough when they reprogrammed terminally differentiated, lineage-restricted adult somatic cells into a pluripotent state via the expression of transcription factors Oct4, Sox2, Klf4, and c-Myc.1 Now, researchers can differentiate reprogrammed induced pluripotent stem cells (iPSCs) into any cell type and…

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Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant

Abstract With the wide adoption of genomic sequencing in children having seizures, an increasing number of SCN2A genetic variants have been revealed as genetic causes of epilepsy. Voltage-gated sodium channel Nav1.2, encoded by gene SCN2A, is predominantly expressed in the pyramidal excitatory neurons and supports action potential (AP) firing. One…

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Scientific webinars on SelectScience

Genome engineering has revolutionized medical research through the ability to precisely edit the DNA sequence of cells. In combination with human induced pluripotent stem cells (hiPSCs), editing the genome can provide unprecedented insight into disease-causing mechanisms on a patient and tissue-specific basis. A major challenge, however, is the efficient generation…

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