Tag: HRS

rPFS and cPFS May Act as Surrogate OS End Points in Phase 3 mHSPC Clinical Trials

Both radiographic progression-free survival (rPFS) and clinical PFS (cPFS) appear to be valid surrogates for overall survival (OS) in phase 3 clinical trials evaluating testosterone suppression–based treatment strategies for patients with metastatic hormone-sensitive prostate cancer (mHSPC), according to findings from a study that were published in the Journal of Clinical…

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Multiple Job openings at Gujarat Biotechnology Research Centre

Government of Gujarat has established Gujarat State Biotechnology Mission (GSBTM) as a nodal agency to develop overall development of biotechnology in the state in 2004. Major activities of GSBTM is promoting research and development in the field of biotechnology and supporting the development of biotechnology industries in the state. Besides…

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IKK gamma (IKBKG) Human shRNA Plasmid Kit (Locus ID 8517)

Product Data Locus ID 8517 Synonyms AMCBX1; EDAID1; FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9 Vector pGFP-C-shLenti E. coli Selection Chloramphenicol (34 ug/ml) Mammalian Cell Selection Puromycin Format Lentiviral plasmids Kit Components IKBKG – Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene…

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Genetic Technologies and BioVie Interviews to Air on the RedChip Small Stocks Big Money(R) Show on Bloomberg TV

ORLANDO, FL / ACCESSWIRE / December 29, 2023 / RedChip Companies will air interviews with Genetic Technologies Limited (NASDAQ:GENE) and BioVie, Inc. (NASDAQ:BIVI) on The RedChip Small Stocks Big Money® Show, a sponsored program on Bloomberg TV, this Saturday, December 30, at 7 p.m. Eastern Time (ET). Bloomberg TV is…

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ZCWCC1 (MORC2) Human shRNA Lentiviral Particle (Locus)

Product Data Locus ID 22880 Synonyms CMT2Z; DIGFAN; ZCW3; ZCWCC1 Vector pGFP-C-shLenti Format Lentiviral particles RefSeq NM_001303256, NM_001303257, NM_014941, NM_014941.1, NM_014941.2, NM_014941.3, NM_001303257.1, NM_001303257.2, NM_001303256.1, NM_001303256.2, BC019257, BC136782, BC141657, BM683680, NM_001303256.3 UniProt ID Q9Y6X9 Summary This gene encodes a member of the Microrchidia (MORC) protein superfamily. The encoded protein is…

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FRK Human shRNA Lentiviral Particle (Locus ID 2444) Clinisciences

Product Data Locus ID 2444 Synonyms GTK; PTK5; RAK Vector pGFP-C-shLenti Format Lentiviral particles RefSeq NM_002031, NM_002031.1, NM_002031.2, BC012916, BC012916.1, NM_002031.3 UniProt ID P42685 Summary The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during…

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DNA Analysis: DNA analysis of severed body parts at Regional Forensic Science Laboratory (RFSL) | Nagpur News

Nagpur: DNA analysis of severed body parts is underway at a war-footing at the Regional Forensic Science Laboratory (RFSL) to identify the nine victims who were killed in a high explosive TNT blast at the Solar Industries India Limited at Kondhali, around 50 km from Nagpur, on Sunday.The analysts are…

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Stk3 Mouse shRNA Plasmid (Locus ID 56274) Clinisciences

Product Data Locus ID 56274 Synonyms 0610042I06Rik; mess1; MST; Mst2; Mst3; Ste20 Vector pGFP-C-shLenti E. coli Selection Chloramphenicol (34 ug/ml) Mammalian Cell Selection Puromycin Format Lentiviral plasmids Kit Components Stk3 – Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 56274). 5µg purified plasmid DNA per construct29-mer…

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Non-Hodgkin Lymphoma Pipeline and Clinical Trials Assessment 2023: FDA Approvals, Therapies and Key Companies involved by DelveInsight

PRESS RELEASE Published December 12, 2023 (Las Vegas, Nevada, United States) As per DelveInsight’s assessment, globally, Non-Hodgkin Lymphoma pipeline constitutes key companies continuously working towards developing Non-Hodgkin Lymphoma treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. The Non-Hodgkin Lymphoma Pipeline report…

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CRISPR Technology Market Size Worth USD 11.64 Billion in

Vancouver, Dec. 12, 2023 (GLOBE NEWSWIRE) — The global CRISPR Technology Market is projected to reach USD 11.64 billion by 2032, according to a recent report by Emergen Research. Certain factors that are driving the market growth include increasing government and personal funding, rising demand and adoption of CRISPR, and…

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NGS Sample Preparation Market Size is Worth USD 10,342.23 Million by 2032

Emergen Research The increased advancements in NGS platforms, a decrease in the price of sequencing, and improving the NGS-based diagnostic test reimbursement scenario are driving the demand for the Next Generation Sequencing (NGS) Sample Preparation market Vancouver, Dec. 11, 2023 (GLOBE NEWSWIRE) — The global next generation sequencing (NGS) sample…

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Computational Biologist – Software Development

Institution/Company: Canada’s Michael Smith Genome Sciences Centre at BC Cancer Location: Vancouver ,&nbspBritish Columbia &nbspCanada Job Type: Programmer/Developer Degree Level Required: Bachelor’s new Apply now Description: Canada’s Michael Smith Genome Sciences Centre (GSC) Today’s Research. Tomorrow’s Medicine. The GSC is a department of the BC Cancer Research Institute and a high-throughput genome…

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Kaggle TPU roberta Finetuning – xla

I have pretrained roberta-base on dna promoter sequences of plants (working on a project). I am currently trying to finetune it on a downstream task of predicting gene expression values, basically a list of 8 values (corresponding to various tissues) from a single promoter sequence. This wasn’t possible on kaggle’s…

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500U | Taq DNA Polymerase, 5u/ul Anawa

Taq DNA Polymerase, 5u/ul Product information Taq DNA Polymerase (New Buffer!) Product Description: Taq DNA Polymerase is a thermosle DNA Polymerase isolated from a strain of Thermus sp. Taq has a half life of 3 hours at 95°C. Taq has high fidelity with an error frequency 10/10^6 (or 0.01/10^3) during…

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Acd Rat shRNA Plasmid (Locus ID 307798) Clinisciences

Product Data Locus ID 307798 Synonyms MGC116400 Vector pRS E. coli Selection Ampicillin Mammalian Cell Selection Puromycin Format Retroviral plasmids Kit Components Acd – Rat, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 307798). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012,…

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Senior Bioinformatics Systems Analyst in Santa Cruz, CA for University of California Santa Cruz

Details Posted: 01-Dec-23 Location: Santa Cruz, California Salary: Open Categories: Information Technology Staff/Administrative Senior Bioinformatics Systems Analyst Location: Santa CruzJob ID: 61781 JOB POSTING NO VISA SPONSORSHIP IS AVAILABLE FOR THIS POSITION.THIS RECRUITMENT WILL REMAIN OPEN UNTIL FILLED. HOW TO APPLY For full consideration, applicants should attach their resume and…

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Single Cell Sequencing Market Size to Reach USD 6,193.01 Million in 2032

Emergen Research Growing usage of single-cell sequencing in oncology is one of the significant factors influencing the Single Cell Sequencing Market growth. Vancouver, Nov. 30, 2023 (GLOBE NEWSWIRE) — The global single-cell sequencing market is expected to reach USD 6,193.01 Million by 2032, according to a new report by Emergen…

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Prime editing-mediated correction of the CFTR W1282X mutation in iPSCs and derived airway epithelial cells

Abstract A major unmet need in the cystic fibrosis (CF) therapeutic landscape is the lack of effective treatments for nonsense CFTR mutations, which affect approximately 10% of CF patients. Correction of nonsense CFTR mutations via genomic editing represents a promising therapeutic approach. In this study, we tested whether prime editing,…

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OAS2 Human shRNA Plasmid Kit (Locus ID 4939) Clinisciences

Product Data Locus ID 4939 Vector pRS E. coli Selection Ampicillin Mammalian Cell Selection Puromycin Format Retroviral plasmids Kit Components OAS2 – Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 4939). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for…

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Genome editing approaches with CRISPR/Cas9: the association of NOX4 expression in breast cancer patients and effectiveness evaluation of different strategies of CRISPR/Cas9 to knockout Nox4 in cancer cells | BMC Cancer

A. Bioinformatics analyzes Search strategy and study selection From April to June 2021, we read relevant and related publications in Medline, EMBASE, Web of Science, and Wanfang. The search term “NOX4” have been used. The articles that fit specified criteria were all added at once: (1) Participants were split into…

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H101 for cervical cancer | DDDT

Introduction Patients with persistent, recurrent, or metastatic (P/R/M) cervical carcinoma respond poorly to treatment despite the best available therapeutic regimens, with a 5-year survival of 17%.1 Most of them are heavily pretreated with chemotherapy and/or radiotherapy, and many patients experience complications related to treatment or advanced disease, which exclude them…

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Temporal Edge Regression with PyTorch Geometric

Exciting News: Towards AI has Launched a Free Course on Training & Fine-Tuning LLMs for Production in collaboration with Activeloop and the Intel Disruptor Initiative!  🤖 60+ Lessons to master state-of-the-art techniques in training and fine-tuning Large Language Models. 📚 🌟 Understand how to combine LLM-optimized hardware and software like…

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NFIB Human shRNA Plasmid Kit (Locus ID 4781) Clinisciences

Product Data Locus ID 4781 Synonyms CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB2; NFIB3 Vector pGFP-V-RS E. coli Selection Kanamycin Mammalian Cell Selection Puromycin Format Retroviral plasmids Kit Components NFIB – Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4781). 5µg purified plasmid DNA per…

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GYPB Human shRNA Plasmid Kit (Locus ID 2994) Clinisciences

Product Data Locus ID 2994 Synonyms CD235b; GPB; GYP; GYPA; MNS; PAS-3; SS Vector pGFP-C-shLenti E. coli Selection Chloramphenicol (34 ug/ml) Mammalian Cell Selection Puromycin Format Lentiviral plasmids Kit Components GYPB – Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 2994). 5µg purified plasmid DNA per…

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AK2 Human shRNA Plasmid Kit (Locus ID 204) Clinisciences

Product Data Locus ID 204 Synonyms ADK2 Vector pGFP-C-shLenti E. coli Selection Chloramphenicol (34 ug/ml) Mammalian Cell Selection Puromycin Format Lentiviral plasmids Kit Components AK2 – Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 204). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti…

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SIGIRR Human shRNA Lentiviral Particle (Locus ID 59307)

Product Data Locus ID 59307 Synonyms IL-1R8; TIR8 Vector pGFP-C-shLenti Format Lentiviral particles RefSeq NM_001135053, NM_001135054, NM_021805, NM_021805.1, NM_021805.2, NM_001135053.1, NM_001135054.1, BC003591, BC003591.1, BC025953, BC106007, NM_001135054.2, NM_001135053.2 UniProt ID Q6IA17 Summary Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling…

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IL6 Human shRNA Plasmid Kit (Locus ID 3569) Clinisciences

Product Data Locus ID 3569 Synonyms BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 Vector pRS E. coli Selection Ampicillin Mammalian Cell Selection Puromycin Format Retroviral plasmids Kit Components IL6 – Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3569). 5µg purified plasmid DNA per construct29-mer…

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Phase 3 DUO-E Study Findings Prove ‘Exciting’ in Advanced Endometrial Cancer

Findings from the phase 3 DUO-E/GOG-3041/ENGOT-EN10 trial (NCT04269200)—assessing combination chemotherapy/durvalumab (Imfinzi), single-agent durvalumab, and durvalumab/olaparib (Lynparza) in patients with newly diagnosed advanced or recurrent endometrial cancer—were “exciting,” according to Shannon N. Westin, MD, MPH, FACOG. In a conversation with CancerNetwork® during the 2023 Annual Global Meeting of the International Gynecologic…

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CD96 Human shRNA Lentiviral Particle (Locus ID 10225)

Product Data Locus ID 10225 Synonyms TACTILE Vector pGFP-C-shLenti Format Lentiviral particles RefSeq NM_001318889, NM_005816, NM_198196, NR_134917, NM_198196.1, NM_198196.2, NM_005816.1, NM_005816.2, NM_005816.3, NM_005816.4, BC020749, BC027914, BM561433, NM_005816.5 UniProt ID P40200 Summary The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The…

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Genome mining yields putative disease-associated ROMK variants with distinct defects

Fig 2. ROMK mutations from TOPMed and ClinVar show varying growth defects in yeast in low potassium medium. (A) Schematic of a yeast-based assay to assess the activity of a human potassium channel. A yeast strain lacking endogenous potassium transporters, Trk1 and Trk2, is viable, yet unable to grow on…

Continue Reading Genome mining yields putative disease-associated ROMK variants with distinct defects

ROMK mutations from TOPMed and ClinVar show varying growth defects in yeast in low potassium medium.

(A) Schematic of a yeast-based assay to assess the activity of a human potassium channel. A yeast strain lacking endogenous potassium transporters, Trk1 and Trk2, is viable, yet unable to grow on medium containing low potassium, unless a human potassium channel (e.g., Kir2.1 or ROMK) is expressed. Because of impaired…

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AMH Human shRNA Plasmid Kit (Locus ID 268) Clinisciences

Product Data Locus ID 268 Synonyms MIF; MIS Vector pRS E. coli Selection Ampicillin Mammalian Cell Selection Puromycin Format Retroviral plasmids Kit Components AMH – Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 268). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector,…

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Use Google Vertex AI Search & Conversation to Build RAG Chatbot

Exciting News: Towards AI has Launched a Free Course on Training & Fine-Tuning LLMs for Production in collaboration with Activeloop and the Intel Disruptor Initiative!  🤖 60+ Lessons to master state-of-the-art techniques in training and fine-tuning Large Language Models. 📚 🌟 Understand how to combine LLM-optimized hardware and software like…

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The ERAD pathway also contributes to ROMK mutant turnover in HEK293 cells.

(A) Stability assays of HEK293 cells expressing wild-type ROMK, or ROMK carrying the G228E, L320P, or N377K mutation. HEK293 cells transfected with the indicated expression vector were treated with MG-132 or the equivalent volume of DMSO for 30 min, at which point cycloheximide was added. Cells were next processed as…

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IGF1 Receptor (IGF1R) Human shRNA Plasmid Kit (Locus ID)

Product Data Locus ID 3480 Synonyms CD221; IGFIR; IGFR; JTK13 Vector pRS E. coli Selection Ampicillin Mammalian Cell Selection Puromycin Format Retroviral plasmids Kit Components IGF1R – Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 3480). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in…

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Advillin (AVIL) Human shRNA Plasmid Kit (Locus ID 10677)

Product Data Locus ID 10677 Synonyms ADVIL; DOC6; NPHS21; p92 Vector pGFP-C-shLenti E. coli Selection Chloramphenicol (34 ug/ml) Mammalian Cell Selection Puromycin Format Lentiviral plasmids Kit Components AVIL – Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 10677). 5µg purified plasmid DNA per construct29-mer scrambled shRNA…

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CHRNA2 Human shRNA Plasmid Kit (Locus ID 1135) Quimigen

Product Data Locus ID 1135 Vector pRS E. coli Selection Ampicillin Mammalian Cell Selection Puromycin Format Retroviral plasmids Kit Components CHRNA2 – Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 1135). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for…

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Announcement: GenePattern Coverage and Support December 24, 2020

From December 24, 2020, through January 3, 2021, the GenePattern team will be out of office for our annual holiday closing. During this time, the GenePattern and GenePattern Notebook servers and repositories will be accessible. We will be monitoring this and, should anything happen to disrupt service, we will work to resolve…

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Genetics and epidemiology of mutational barcode-defined clonal hematopoiesis

Identification of CH cases from WGS in ISL and UKB We used WGS from 45,510 Icelanders and 130,709 British ancestry participants from the UKB17,18. Average sequencing depth was 33× for UKB and 38× for ISL. Participants with prior diagnoses of hematological disorders or grossly abnormal hematology measurements on entry were…

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An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission

Mice and Golden Syrian hamsters All research experiments in this study comply with all relevant ethical regulations. The Institutional Animal Care and Use Committee approved the animal protocol at the University of Maryland (#R-APR-20-18 and #R-MAR-21-19). The animals were acclimatized at the animal facility for 4–6 days before initiating experiments….

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Fibronectin (FN1) Human shRNA Plasmid Kit (Locus ID 2335)

Product Data Locus ID 2335 Synonyms CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF; SMDCF Vector pGFP-V-RS E. coli Selection Kanamycin Mammalian Cell Selection Puromycin Format Retroviral plasmids Kit Components FN1 – Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 2335). 5µg purified plasmid DNA…

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Innovation Associate – Data Analytics & Bioinformatics job with Hyper Recruitment Solutions Ltd

We are currently looking for a Innovation Associate for Data Analytics & Bioinformatics to join a global Life Sciences company based in the Cambridgeshire area. As the Innovation Associate for Data Analytics & Bioinformatics you will work with stakeholders and leverage external networks to search, identify and evaluate opportunities and…

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Sobuzoxane Combo Extends Survival in Elderly DLBCL Group

“Our findings may suggest that R-PVP therapy is one of the safe and effective treatments for a subgroup of patients, i.e., those who may have high CCI [scores] or low tumor burden, among untreated DLBCL patients aged over 80 [years],” according to the authors of a retrospective analysis. Elderly patients…

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A non-randomized risk-adjusted comparison of lenalidomide + R-CHOP versus R-CHOP for MYC-rearranged DLBCL patients

Patients with MYC rearranged (MYC-R) diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Previously, we demonstrated in a single-arm phase II trial (HOVON-130) that addition of lenalidomide to R-CHOP (R2CHOP) is well-tolerated and yields similar complete metabolic remission rates as more intensive chemotherapy regimens in literature. In parallel with…

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Frontline Sobuzoxane Plus Etoposide and Rituximab is Safe and Effective in Older DLBCL Population

The combination of sobuzoxane (MST-16) and etoposide plus rituximab (Rituxan; R-PVP) prolonged survival and showcased a tolerable safety profile in patients with previously untreated diffuse large B-cell lymphoma (DLBCL) aged 80 years and older, according to findings from a retrospective analysis, which were presented at the 2023 ESMO Congress.1 At…

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Frontline Sobuzoxane/Etoposide/Rituximab is Safe and Effective in DLBCL Subgroup

Lymphomas: © David A Litman – stock.adobe.com Sobuzoxane (MST-16), etoposide, and rituximab (Rituxan; R-PVP) used in combination were found to prolong survival and showcase a tolerable safety profile in patients with previously untreated diffuse large B-cell lymphoma (DLBCL) who were aged 80 years and older, according to findings from a…

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Hyper Recruitment Solutions hiring Software Engineer – Bioinformatics in United Kingdom

We are currently looking for a Bioinformatics Software Developer to join an exciting start up based in the Oxfordshire area but you can be remote. As the Bioinformatics Software Developer you will support to Bioinformatics team to create software and pipeline for biological analysis KEY DUTIES AND RESPONSIBILITIES: Your duties…

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Electroporation Instrument Market Size 2023, Forecast By 2032

Market Synopsis The global electroporation instrument market size was USD 440.29 Million in 2022 and is expected to reach USD 917.50 Million in 2032, and register a revenue CAGR of 8.5% during the forecast period. The demand for electroporation technology in the healthcare and Biotechnology sectors is on the rise,…

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Questions 2-3) Consider the following diagrams

Transcribed image text: Questions 2-3) Consider the following diagrams showing gene expression levels after whole genome gene expression analysis (e.g. RNA Seq). The experiments are in zebrafish, where MBT occurs around 3 hours post fertilization. Each dot represents a specific gene and both axes represent gene expression levels (read counts…

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Bioinformatics Programmer (BIOINFORMATICS PROGR 2) – Neurology – Sacramento Campus job with University of California, Davis

Job Title: Bioinformatics Programmer (BIOINFORMATICS PROGR 2) – Neurology – Sacramento Campus Location: Sacramento Full/Part Time: Full Time Job ID: 50752 Job Summary This position reports to the UC Davis Alzheimer’s Disease Research Center (ADRC) Administrative Director in the Department of Neurology. This position supports basic and clinical research and…

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Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy

Rab8A and Rab41 are required for xenophagy of GAS For comprehensive screening of Rab GTPases involved in xenophagy against GAS infection, we first knocked down the expression of Rab GTPases in HeLa cells. We examined bacterial survival in cells at 6 h post-infection (hpi) compared with that at 2 hpi because…

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Tislelizumab vs Sorafenib as First-Line Treatment for Unresectable Hepatocellular Carcinoma: A Phase 3 Randomized Clinical Trial | Targeted and Immune Cancer Therapy | JAMA Oncology

Key Points Question  How does the efficacy and safety profile of tislelizumab compare with that of sorafenib as first-line treatment among patients with unresectable hepatocellular carcinoma (HCC)? Findings  In this phase 3 randomized clinical trial of 674 patients with HCC, tislelizumab demonstrated overall survival noninferiority compared with sorafenib, with numerically…

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EMBL-EBI virtual course | Introduction to RNA-seq and functional interpretation

Applications close: 29 October 2023 Course dates: 12 – 16 February 2024 Course fee: £225.00 APPLY NOW Gain an introduction to the technology, data analysis, tools, and resources used in RNA sequencing and transcriptomics. The content will provide a broad overview of the subject area, and introduce participants to basic…

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Efforts Are Underway to Refine Prognostic Value of ctDNA to Guide Adjuvant Therapy in CRC

Circulating tumor DNA(ctDNA) status at the time of postoperative minimal residual disease (MRD) is a prognostic factor of recurrence for patients with radically resected stage II to IV colorectal cancer (CRC). Standard management calls for adjuvant chemotherapy for all patients following surgical resection; however, investi- gators have sought to refine…

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Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K+ during entry

An improved STA of the BUNV GP permits modelling of the Gc and Gn hetero-hexameric arrangement To determine the arrangement of Gn and Gc in the BUNV spike by cryo-EM, WT BUNV was concentrated and purified as previously described5,25 (Supplementary Fig. 1). Purified virions (in a pH 7.3/no K+ buffer) were…

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Salmon index not progressing

Salmon index not progressing 0 Hi! I am having issue with salmon index formation since I cannot use STAR due to limited amount of RAM (as per my recent post). I tried to follow this tutorial on how to create decoy-aware transcriptome as well as doing directly this and I…

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python – The time to submit a notebook in a kaggle competition is 5 times longer than if run locally – 7 hrs versus 1.2 hrs

In the Kaggle CommonLit – Evaluate Student Summaries competition, one can submit upto 5 submissions daily. Each of these submissions are run with about 15% of the final number of tests. The final tests number is 20,000. 15% being 3000 tests. In the kaggle local environment provided for development, when…

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EBV-positive diffuse large B cell lymphoma

By Jason Wasserman MD PhD FRCPCSeptember 19, 2023 What is EBV-positive diffuse large B cell lymphoma? EBV-positive diffuse large B cell lymphoma (DLBCL) is a type of immune system cancer. It is made up of abnormal B cells that have been infected with Epstein-Barr virus (EBV). What parts of the…

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The next generation of skin formulations

18-Sep-2023 In 1990, there was the initiative called the Human Genome Project that took 13 years to sequence the human genome, the building blocks of human life. Those same results can now be obtained in just a few days, with the Guinness World Record of just 5 hrs. and 2…

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Viruses | Free Full-Text | Optimizing the Conditions for Whole-Genome Sequencing of Avian Reoviruses

1. Introduction Avian orthoreoviruses (avian reoviruses, ARVs) are a persistent challenge to poultry producers in the United States and globally. Infection with ARVs has been associated with a variety of symptoms and syndromes in commercial poultry, including tenosynovitis/viral arthritis, enteric symptoms such as watery diarrhea, respiratory symptoms, myocarditis, viral hepatitis,…

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Genome analysis of ST1 Bartonella henselae

Introduction Infective endocarditis (IE), as a disease first recognized in 1885, is defined by infection of a native or prosthetic heart valve, the endocardial surface, or an indwelling cardiac device.1–3 Despite advances in diagnostic capabilities and treatment options, IE remains a rare condition but with high associated mortality. And epidemiological…

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Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk

The details of study participants, plasma ApoE measurement, genotyping and imputation, statistical analyses, and functional annotations are given in Online Methods. Association of plasma ApoE concentration with incident dementia and cognition function Whole plasma ApoE concentration at baseline was determined in 3031 participants, of which 2893 were European Americans (EAs),…

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Director, Bioinformatics – Immunology Center of Georgia job with Augusta University

Director, Bioinformatics – Immunology Center of Georgia Job ID: 253563Location: Augusta UniversityFull/Part Time: Full TimeRegular/Temporary: * About UsAugusta University is Georgia’s innovation center for education and health care, training the next generation of innovators, leaders, and healthcare providers in classrooms and clinics on four campuses in Augusta and locations across…

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Bioinformatics Programmer 2 – 124783 Job in California

Payroll Title:BIOINFORMATICS PROGR 2 Department:CELLULAR & MOLECULAR MEDICINE Hiring Pay Scale$63,000 – $88,000 / Year Worksite:Campus Appointment Type:Career Appointment Percent:100% Union:Uncovered Total Openings:2 Work Schedule:Days, 8 hrs/day, Monday – Friday #124783 Bioinformatics Programmer 2Filing Deadline: Tue 9/5/2023 Apply Now UC San Diego values equity, diversity, and inclusion. If you…

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Bioinformatics Programmer 1 – 124782 job in Oakland, California at UC San Diego

Bioinformatics Programmer 1 – 124782 Job Description Filing Deadline: Tue 9/5/2023 UC San Diego values equity, diversity, and inclusion. If you are interested in being part of our team, possess the needed licensure and certifications, and feel that you have most of the qualifications and/or transferable skills for a job…

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First global consultancy tender launched for Hyderabad Metro Phase 3 corridors |Metro Rail Today

Hyderabad, India (Metro Rail Today): Hyderabad Airport Metro Limited (HAML) is engaged in the development of Mass Rapid Transit System (MRTS) in the city of Hyderabad. As a part of this endeavor, HAML intends to prepare Preliminary Project Reports (PPRs) and Detailed Project Reports (DPRs) for development Mass Rapid Transit System…

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Meta-Analysis Compares Treatment Options for DLBCL

Rituximab with gemcitabine, dexamethasone, and cisplatin (R-GDP) regimen improved overall survival (OS) and progression-free survival (PFS) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) compared to other salvage chemotherapy (SC) regimens, according to a network meta-analysis published in Leukemia & Lymphoma. The analysis also found that chimeric antigen receptor…

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Sage Bionetworks Bioinformatics Engineer in Seattle, WA | 859877523

Employer: Sage Bionetworks Location: 2901 3rd Ave, Suite 330 Seattle, WA 98121 Title: Bioinformatics Engineer Duties: Rapidly prototype, assess, and deploy systems for harmonizing, sharing, and analyzing biomedical data while working closely with Sage scientists and the Computational Biology Team. Develop and prototype tools to facilitate tracking, scalability, and reproducibility…

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Bioinformatics Programmer – Hybrid/Remote – 123642 Job in , Higher Education Career, Jobs in University of California San Diego

Payroll Title:BIOINFORMATICS PROGR 1 Department:CELLULAR & MOLECULAR MEDICINE Hiring Pay Scale$55,000 – $92,000 / Year Worksite:Hybrid Remote Appointment Type:Career Appointment Percent:100% Union:Uncovered Total Openings:1 Work Schedule:Days, 8 hrs/day, Monday – Friday #123642 Bioinformatics Programmer – Hybrid/RemoteExtended Deadline: Fri 8/4/2023 Apply Now UC San Diego values equity, diversity, and inclusion….

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Sessional Lecturer BIO362H5F – Bioinformatics – University of Toronto – job portal

Press Tab to Move to Skip to Content Link Sessional Lecturer BIO362H5F – Bioinformatics Course number and title: BIO362H5F – Bioinformatics   Course description: Bioinformatics uses and develops computational tools to understand biological processes from the level of single molecules to whole genomes and organisms. The biotechnology revolution has meant…

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Microbiologist (Next Generation Sequencing) – Richmond

SUMMARY The Infectious Disease Laboratory Branch (IDLB) is currently seeking a highly motivated Microbiologist to join the Genomics Center group. In this role, the candidate will work collaboratively and cross-functionally with colleagues to execute Next-Generation Sequencing (NGS) workflows that support the surveillance, diagnostics, and research efforts of the California Department…

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Inspire Faculty Fellowship 2023 DST – Rs 1.25 Lakh pm

Inspire Faculty Fellowship 2023 DST – Rs 1.25 Lakh pm + Rs 7 Lakh Research Grant Inspire Faculty Fellowship 2023 DST – Rs 1.25 Lakh pm + Rs 7 Lakh Research Grant. Innovation in Science Pursuit for Inspired Research(INSPIRE) Faculty Fellowship Scheme 2023 Official Notification has been released. Interested applicants…

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bbtools.eth | Address 0xa15869d1a77f2c02816bdd790d45718df9577b1f | Etherscan

” data-bs-custom-class=”popover-preview”> 0x159c17002d59e8b7513d28910c28f6ccbfc077148a85539e40774d6a718309fd Manual Swap 17743081 2023-07-21 17:43:35 1 hr 31 mins ago 1689961415 bbtools.eth OUT 0xbD1b10…96591FBD 0 ETH 0.00612944 40.29164342 ” data-bs-custom-class=”popover-preview”> 0xad5be3731f276b571633d06f44d22b915eb1d1834c3de43f24b96f7dda79d32a Transfer 17739082 2023-07-21 4:17:11 14 hrs 57 mins ago 1689913031 bbtools.eth OUT 0xbD1b10…96591FBD 0 ETH 0.00074844 15.92088759 ” data-bs-custom-class=”popover-preview”> 0xbc4300a2eaa4e1f0ea5fec4916ef594b97b006a8df26348233d0e9f18edc03fc Execute 17739079 2023-07-21 4:16:35 14 hrs…

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Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry

Constructs and expression of human SERINC proteins SERINC3 The gene that encodes human SERINC3 (Genscript-OHu02717D) was inserted upstream of a thrombin protease cleavable linker (LVPRGS) and Strep II epitope (WSHPQFEK) in a modified pFastBac vector by In-Fusion cloning (Clontech). Mutagenesis using the QuikChange Site-Directed Mutagenesis kit (Agilent) was performed to…

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Hello, I need help with this rstudio task, any help

Hello, I need help with this rstudio task, any help would be greatly appreciated! For each data set, please show a plot of: relevant dependent variable (DV) vs. hrs/day working out with a 1st order polynomial (straight line) fit a plot of the residuals “left over” from the straight line…

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Anti DsDNA (Double Stranded) Antibodies Lab Testing in North Miami Beach, FL

Order your Anti dsDNA (Double stranded) Antibodies test online and save with Personalabs. Get the same tests your doctor prescribes without the hassle of the office visit. Order your labs, visit a local draw center, and receive your results in as little as 48 hours in most cases. SAVE 30%…

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Brent Sam, Justin Garcia keep Defence Force rolling

Sports Jelani Beckles 6 Hrs Ago Defence Force striker Brent Sam. – (FILE) A BRACE each from Brent Sam and Justin Garcia kept Defence Force’s dream alive of doing the doubles this year after crushing Queen’s Park 6-1 in the quarter-finals of the TT Premier Football League Knock-Out tournament at…

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Bioinformatics Scientist, Sr job with John Wiley & Sons , Inc.

Description Schedule: Monday – Friday (40 hrs/wk)8:00 AM – 5:00 PM Department: Research and Innovation – 249 Primary Purpose: As a part of the Institute for Research and Innovation in Diagnost ic and Precision Medicine, a dvance the state-of-the-art clinical diagnosis and treatment by gathering, storing, manipulating, and analyzing clinical…

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Best Pytorch Courses Online & Certification (July 2023)

Whether you’re a Python developer, machine learning engineer, or any professional, it is never too late to learn another skill. Python’s most powerful library – Pytorch, is not a trend, but a valuable asset. The three most popular industries that use Pytorch are AI, Machine Learning, and Deep Learning. So,…

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How to merge BLE_UART and Aes_ctr project file – Nordic Q&A – Nordic DevZone

Hello, I have two project one is Ble UART and second AES_ctr, i want to combine AES_ctr project and sdk_config.h file into BLE_UART ,so i can use AES API in BLE UART code can you guide me how to start it. <!DOCTYPE CrossStudio_Project_File> <solution Name=”nrf_crypto_aes_ctr_pca10056″ target=”8″ version=”2″> <project Name=”nrf_crypto_aes_ctr_pca10056″> <configuration …

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Researchers urge caution in gene editing ear

Copenhagen, Denmark: Scientists have discovered that the cells of early human embryos are often unable to repair damage to their DNA. The researchers say that this has important implications for the proposed use of gene editing techniques to remove serious inherited diseases from embryos, as well as for IVF in…

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Bioinformatics Programmer and Integration Manager – 110035 job in Oakland, California at UC San Diego

Bioinformatics Programmer and Integration Manager – 110035 Job Description Extended Deadline: Mon 6/26/2023 UC San Diego values equity, diversity, and inclusion. If you are interested in being part of our team, possess the needed licensure and certifications, and feel that you have most of the qualifications and/or transferable skills for…

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Intern (per diem), Bioinformatics – Get Hired Fast at D-H Lebanon-Mhmh in Lebanon, NH

We are looking for a driven Intern (per diem), Bioinformatics to join our amazing team at D-H Lebanon-MHMH in Lebanon, NH.Growing your career as a Internship Intern (per diem), Bioinformatics is an awesome opportunity to develop excellent skills.If you are strong in problem-solving, communication and have the right mindset for…

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Is it possible to use salmon alevin tool for total rna seq samples?

Is it possible to use salmon alevin tool for total rna seq samples? 1 Hi All, I’m interested to quantify the propositions of spliced vs unspliced transcripts at transcript level. As pointed out this page(combine-lab.github.io/alevin-tutorial/2020/alevin-velocity/). But they used single-RNA sequencing data so, it is salmon alevin. But what i did…

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ICML 2023 Meeting: CFT7455 in NHL Preclinical Presentation

CFT7455: A novel IKZF1/3 degrader, demonstrates potent anti-tumor activity in peripheral and CNS models of non-Hodgkin’s lymphoma as a single agent or in combination with clinically approved agents Samantha Perino, R. Jason Kirby, Roman V. Agafonov, Prasoon Chaturvedi, Scott J. Eron, Andrew Good, June A. Hart, Minsheng…

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Sequencing Hodgkin lymphoma | Drug Discovery News

Like trying to find a lit match in a room full of burning furniture, isolating cancerous Hodgkin lymphoma cells from inside an inflamed tumor is a challenge that has hampered efforts to better understand the cancer’s genes and biology. Now, a group of researchers has isolated cancerous cells from noncancerous…

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Microbiologist (Next Generation Sequencing) job with Public Health Foundation Enterprises, In

SUMMARY The Infectious Disease Laboratory Branch (IDLB) is currently seeking a highly motivated Microbiologist to join the Genomics Center group. In this role, the candidate will work collaboratively and cross-functionally with colleagues to execute Next-Generation Sequencing (NGS) workflows that support the surveillance, diagnostics, and research efforts of the California Department…

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Pulsed field ablation shows more positive data as treatment for AFib

One of the biggest technology trends in cardiac electrophysiology is the the development of pulsed field ablation (PFA), a non-thermal ablation treatment for patients with atrial fibrillation (AF). The Heart Rhythm Society (HRS) included three positive late-breaking clinical studies at its Heart Rhythm 2023 meeting in May that may help…

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SPECTRAFORCE hiring Bioinformatics Analyst III in North Chicago, Illinois, United States

Title: Bioinformatics Analyst III Duration: 12 Months Location/Site: 100% Remote Pay Rate: $51/hr. – $56/hr. on w2 Job Description Services Overview: Services include support of computational research priorities associated with oncology discovery programs. This variably entails querying public cancer genomics resources for mutation/expression distributions, assessing normal expression, interpreting germline associations…

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PLOD1 shRNA depletion and small molecule inhibition with 2-DP destabilize EBNA1 protein.

A) Raji cells transduced with lentivirus shControl (shCtrl) or shPLOD1 (pool a) were assayed by Western blot for PLOD1, EBNA1, EBNA2, LMP1, or Actin at 7 days post-transduction. Each lane is a biological replicate. B) Raji (left) or LCL (right) treated with DMSO or 2,’2-dipyridil (2-DP, 200 μM) were assayed…

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Comparison of 16S rRNA Gene Quantification with Selected Inflammatory Markers and Culture Method in Septic Arthritis

Distinguishing SA from other inflammatory joint conditions is based on clinical and routine laboratory investigations representing a diagnostic challenge.4 The SF volume in normal joints varies from a few drops in small joints to several millilitres in larger joints. SF volume in the normal knee joint is from 0.2 to…

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Sessional Lecturer – BIO362H5 – Bioinformatics

Course number and title: BIO362H5 – Bioinformatics Course description:   Bioinformatics uses and develops computational tools to understand biological processes from the level of single molecules to whole genomes and organisms. The biotechnology revolution has meant that bioinformatics is now used in many cutting…

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Calling MPI subprocess within python script run from SLURM job

I am having trouble launching a SLURM job calling a mpirun subprocess from a python script. Inside the python script (let’s call it script.py) I have this subprocess.run: import subprocess def run_mpi(config_name, np, working_dir): data_path = working_dir + “/” + config_name subprocess.run( [ “mpirun -np ” + np + “…

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python project(use sagemath) – Freelance job in IT And Networking

Looking for someone that has python experience and also knows how to use sagemath (The project involves building graph using python functions) send me a proposal with your previous works. Thanks! About the recuiterMember since Jul 14, 2017 Alexm from New Jersey, United States Open for hiringApply before – Nov…

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HRS 2023: Late-breaking clinical trial results support PFA as treatment option for atrial fibrillation

New data from three late-breaking clinical trials has demonstrated the safety and efficacy of pulsed field ablation (PFA) as a viable, non-thermal treatment option for atrial fibrillation (AF) and were presented at the 2023 Heart Rhythm (May 19–21, New Orleans, USA) annual meeting. Today, the standard approaches to AF treatment…

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Sequencing Center Manager, BYU job with Brigham Young University DNASC

The Department of Biology at Brigham Young University is seeking a full-time manager for the BYU DNA Sequencing Center. Candidates with a PhD and experience in nucleic acid sequencing are encouraged to apply. Those with a Master’s degree and substantial lab or managerial experience in nucleic acid sequencing and analysis…

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r – exponential decay fitting line and equation in the plot using ggplot2

I have a dataset www.dropbox.com/s/qemmepoq105rth2/sample_data_trasport.csv?dl=0 using code shapes <- c(5, 16, 18, 3, 15, 4, 6, 8, 17, 13, 2) trasport_time %>% filter(PM2.5 > 25) %>% ggplot(aes(x = Transport_time_hrs, y = mac_405, shape=(Fire_Name), color=(day))) + geom_point( alpha=1, size = 4)+ scale_shape_manual(values = shapes)+ xlim(0,25)+ ylim(0,1.5) + #geom_smooth(aes(group = 1),method=nls, se=F)+…

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Identification of age-specific gene regulators of La Crosse virus neuroinvasion and pathogenesis

RNA-seq analyses of adult and weanling brain microvessels identify candidate gene regulators of LACV infection We first sought to identify candidate gene regulators that contribute to age-dependent susceptibility to LACV. Weanling (W) and adult (A) mice were treated with either poly I:C (PI) for 3 h (as a surrogate for a…

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Anti DsDNA (Double Stranded) Antibodies Lab Testing in Tulsa, OK

Order your Anti dsDNA (Double stranded) Antibodies test online and save with Personalabs. Get the same tests your doctor prescribes without the hassle of the office visit. Order your labs, visit a local draw center, and receive your results in as little as 48 hours in most cases. SAVE 30%…

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