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Tag: IGM
Domestic pigs are susceptible to experimental infection with non-human primate-derived Reston virus without the need for adaptation
Ethics and animal welfare statement All infectious work with RESTV, including sample inactivation, was performed in the Containment Level 4 laboratory (CL4) in accordance with the policies and protocols outlined by the Canadian Science Centre for Human and Animal Health Institutional Biosafety Committee. All animal work was performed in strict…
What is B-Cell Receptor Repertoire Sequencing?
What is BCR-seq? B cell receptor sequencing (BCR-seq) represents an advanced and rapid method for the exhaustive detection of target-amplified B-cell receptors (BCRs) through the integration of high-throughput sequencing technology and bioinformatics. By scrutinizing the abundance of each sequence, BCR-seq unveils the intricacies of B-cell-mediated humoral immune responses and the…
Learning from cerebrospinal fluid drug-resistant HIV escape-associated encephalitis: a case report | Virology Journal
A 27-year-old HIV-positive Chinese Manchu male complained of intermittent headache, nausea, and vomiting (non-projectile vomiting three times in total) for two weeks in January 2022. No fever, amaurosis, or unconsciousness were presented. He denied preceding travel or unusual animal exposures. He was diagnosed with HIV infection five years ago and…
Biosensors | Free Full-Text | CRISPR/Cas12a-Based Detection Platform for Early and Rapid Diagnosis of Scrub Typhus
1. Introduction Orientia tsutsugamushi (OT) is an obligate intracellular parasite bacteria and the causative agent of scrub typhus (ST), which is associated with acute febrile illness (AFI) [1] and transmitted by mites through an infected chigger bite (in the larval stage). This disease, which was earlier believed to be endemic…
Metagenomic next-gene sequencing for respiratory infections
Introduction Respiratory tract infections are common and occur frequently. Rapid and accurate microbial detection is essential for timely and appropriate treatment. Traditional microbial detection methods have some limitations such as dependence on morphology, long duration, low sensitivity, and high variability.1,2 Metagenomic next-generation sequencing (mNGS) is a new detection technology characterized…
Fermentation | Free Full-Text | Whole-Genome Sequencing of Lactiplantibacillus plantarum YY-112 and Investigation of Its Immune-Modulating Abilities In Vivo
Author Contributions Conceptualization, Y.Y. and Y.G.; Data curation, M.L. and W.Z.; Formal analysis, M.L., W.Z., W.T. and J.L.; Funding acquisition, Y.Y. and Y.G.; Investigation, J.X., Y.Y. and Y.G.; Methodology, M.L., J.L. and Y.Y.; Project administration, Y.Y.; Resources, J.X., Y.Y. and Y.G.; Software, M.L., W.Z. and W.T.; Supervision, J.X., Y.Y. and…
The Evolving Market Dynamics of B-cell Lymphomas: Diffuse Large B-cell Lymphoma, Follicular Lymphoma, Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma, Marginal Zone Lymphoma, Waldenstrom Macroglobulinemia, and Burkitt Lymphoma
B-cell lymphoma, a subtype of non-Hodgkin lymphoma, stands as the leading cancer diagnosis in the United States, comprising 85% of all cases. This cancer targets the lymphatic system, encompassing lymph nodes, vessels, and related tissues responsible for fluid transportation within the body. The outlook for B-cell lymphoma patients has been…
Hep B – information for hepatitisB – Hepatitis B: dsDNA virus Can survive outside the body for up to
Hepatitis B: dsDNA virus Can survive outside the body for up to 7 days! Only about 5% of acute cases become chronic in adults, while 90% become chronic in children! Transmission Parenteral route (percutaneously, mucosal contact, sexual contact, OR perinatal) Screening Recommendations High risk behaviors, Conditional risk exposures, HIV infection,…
Diagnosis of Two meningitis Cases caused by Rickettsia felis
Introduction Rickettsia felis belongs to the transitional group in the genus Rickettsia and is mainly transmitted by the cat flea (Ctenocephalides felis) but has been detected in a variety of arthropods including mosquitoes, ticks, and mites.1 Flea-borne spotted fever is caused by R. felis, with symptoms including fever, headache, and…
Mosunetuzumab in combination with CHOP in previously untreated DLBCL: safety and efficacy results from a phase 2 study
Abstract Up to 40% of patients with diffuse large B-cell lymphoma (DLBCL) are refractory to or relapse after first-line therapy, highlighting the need for better treatments. Mosunetuzumab is a CD20 × CD3 bispecific antibody that engages and redirects T cells to eliminate malignant B cells. In this phase 2, open-label study…
Artificial surface labelling of Escherichia coli with StrepTagII antigen to study how monoclonal antibodies drive complement-mediated killing
Delcour, A. H. Outer membrane permeability and antibiotic resistance. Biochim. Biophys. Acta 1794, 808 (2009). Article CAS PubMed Google Scholar Silhavy, T. J., Kahne, D. & Walker, S. The bacterial cell envelope. Cold Spring Harb. Perspect. Biol. 2, a000414 (2010). Article PubMed PubMed Central Google Scholar Lu, L. L., Suscovich,…
Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells | Cancer Research
Fasting-mimicking diet (FMD) is emerging as an effective dietary intervention with the potential to prolong life span in healthy people and boost antitumor immunity in patients with cancer. FMD refers to a medically designed fasting-like state that allows periodic consumption of a very-low-calorie and low-protein diet (1, 2). Compared with…
Leishmania genetic exchange is mediated by IgM natural antibodies
Rapaka, R. R. et al. Conserved natural IgM antibodies mediate innate and adaptive immunity against the opportunistic fungus Pneumocystis murina. J. Exp. Med. 207, 2907–2919 (2010). Article CAS PubMed PubMed Central Google Scholar Boehm, T., Iwanami, N. & Hess, I. Evolution of the immune system in the lower vertebrates. Annu….
Establishment and Performance Evaluation of Multiplex PCR-Dipstick DNA Chromatography for Mycoplasma pneumoniae and Chlamydia pneumoniae Rapid Detection
Background and Objective. Mycoplasma pneumoniae (MP) and Chlamydia pneumoniae (CP) infections are becoming increasingly prominent in respiratory infections. This study established a rapid, simple, sensitive, accurate multiplex PCR-dipstick DNA chromatography assay for Mycoplasma pneumoniae and Chlamydia pneumoniae detection. Methods. Nasopharyngeal swab samples of 300 children with an acute respiratory tract…
Metagenomics as new tool for diagnosis of scrub typhus
Introduction Scrub typhus, a kind of zoonotic bacterial infection, is becoming a threat to public health,1 which usually occurs to field operators, especially those living in remote and rural areas.2 Scrub typhus is caused by Orientia tsutsugamushi that is a kind of bacteria of gram-negative coccobacillus,3 the latent period is…
Generation of inactivated IL2RG and RAG1 monkeys with severe combined immunodeficiency using base editing
Animals The gene targeting experiment was conducted on cynomolgus monkeys, which served as the experimental subjects. These monkeys were housed at Guangdong LANDAU Biotechnology Co. Ltd and TOPGENE Biotechnology Co. Ltd, where they received unrestricted access to water and were provided with a standard diet in accordance with standard care…
Comparison of the overall performance of RPA-CRISPR/Cas12a FBDA, Leptospira IgM RDT, and both tests combined.
(a) Comparison of each individual test’s specificity, sensitivity, and accuracy to the combined test. P-values ≤ 0.05 are considered statistically significant. Figs were made using GraphPad Prism 9 (GraphPad Software Inc., California, USA). (b) The Venn diagram created by Microsoft PowerPoint 2021(US) represented the number of cases diagnosed by each…
An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants
Protein expression hACE2-hIgG1 was constructed by fusing the extracellular domain of human ACE2 (amino acid 19–615) (UniProt Q9BYF1) to the human IgG1 hinge and Fc (UniProt P01857). H374N and H378N mutations were introduced to inactivate the Zinc metallo-enzyme activity17. HH-120 was constructed by fusing hACE2-hIgG1 with an IgM tailpiece (PTLYNVSLVMSDTAGTCY)33….
ETS1 phosphorylation at threonine 38 is associated with the cell of origin of diffuse large B cell lymphoma and sustains the growth of tumour cells
doi: 10.1111/bjh.19018. Online ahead of print. Elaine Y L Chung 1 , Giulio Sartori 1 , Maurilio Ponzoni 2 , Luciano Cascione 1 3 , Valdemar Priebe 1 , Zijun Y Xu-Monette 4 , Xiaosheng Fang 4 , Mingzhi Zhang 4 , Carlo Visco 5 , Alexandar Tzankov 6 , Andrea Rinaldi 1 , Jacopo Sgrignani 7 , Emanuele Zucca 8…
Dynamic thresholding and tissue dissociation optimization for CITE-seq identifies differential surface protein abundance in metastatic melanoma
Workflow overview CITE-seq and cell hashing were performed on liquid and solid tissue biopsies (Fig. 1a, b). Experimentally, cells from 17 samples (Supplementary Data 2) were hashed and stained with a panel of 97 antibodies (Supplementary Data 2) covering key as well as exploratory immuno-oncology markers resulting in 57,261 cells after preprocessing and…
ADC terminates Phase II trial for lymphoma therapy
Sobi has exclusive rights for marketing Zynlonta in the EU and other international markets, except the US, Greater China, Singapore, and Japan. Image Credit: meeboonstudio / Shutterstock. ADC Therapeutics will terminate the Phase II LOTIS-9 clinical trial evaluating Zynlonta (loncastuximab tesirine-lpyl) and Rituxan (rituximab) in unfit or frail patients with…
Treatment of adults with relapsed or refractory DLBCL
Introduction Diffuse Large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for 31% of NHL cases in Western countries.1,2 The median age at presentation is 66, and 5-year survival rates decrease by age from 78% for those younger than 55 years to 54% for those over 65…
Aridis Receives Agreement from the European Medicines
LOS GATOS, Calif., July 17, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced positive feedback from the European Medicines Agency (EMA) on the Company’s proposed single confirmatory Phase 3 study of investigational monoclonal antibody candidate AR-301, which is being developed as an adjunctive therapy in combination with…
A geopositioned and evidence-graded pan-species compendium of Mayaro virus occurrence
Anderson, C. R., Downs, W. G., Wattley, G. H., Ahin, N. W. & Reese, A. A. Mayaro virus: a new human disease agent. II. Isolation from blood of patients in Trinidad, B.W.I. Am. J. Trop. Med. Hyg. 6, 1012–1016, doi.org/10.4269/ajtmh.1957.6.1012 (1957). Article CAS PubMed Google Scholar Causey, O. R. &…
IJMS | Free Full-Text | Combining 16S rRNA Sequencing and Metabolomics Data to Decipher the Interactions between Gut Microbiota, Host Immunity, and Metabolites in Diarrheic Young Small Ruminants
IgG and IL-1β concentration were positively correlated to Patescibacteria, Clostridiaceae, and unclassified_Muribaculaceae content in diarrheic animals. Furthermore, Alb concentration was positively related to more bacteria, including Patescibacteria, Campylobacterota, unclassified_Lachnospiraceae, unclassified_ Muribaculaceae, UCG_005, Clostridium_sensu_stricto_1, and Clostridiaceae. However, Firmicutes were negatively correlated with TP concentration (Figure 6A). Interestingly, more bacteria were significantly…
Clinical Value of Metagenomics | IDR
Introduction Mycoplasma pneumoniae is an important infectious pathogen of lower respiratory tract infection in children and adolescents. M. pneumoniae pneumonia (MPP) accounts for 30% to 40% of community-acquired pneumonia in children.1 The first-line antibiotic for treating MPP is macrolides. Due to the widespread use of macrolides, instances of M. pneumoniae…
Aridis’ AR-301 Monoclonal Antibody is Among the First
QIDP designation for Biologics provides FDA Priority Review status LOS GATOS, Calif., July 12, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS), a biopharmaceutical company focused on the discovery and development of novel anti-infective therapies for treating life-threatening infections, today announced that the U.S. Food and Drug Administration (FDA)…
ASCO Reading Room | Loretta Nastoupil, MD, on the Rapidly Evolving Treatment Landscape for DLBCL
Several promising therapies for newly diagnosed and relapsed diffuse large B-cell lymphoma (DLBCL) patients have been recently approved or are in the final stages of development, including enhanced monoclonal antibodies, antibody-drug conjugates, and T-cell–engaging therapies. Over the last few years, the bottom-line approach to DLBCL, the most common B-cell lymphoma,…
Dr James Howard Explains Mechanisms of Action of Newer Myasthenia Gravis Therapies
James F. Howard Jr, MD, professor of neurology at the University of North Carolina at Chapel Hill, former chief of the Neuromuscular Disorders Division, and former James F. Howard Distinguished Professor of Neuromuscular Disease, discusses how future treatments for myasthenia gravis will have more targeted mechanisms of action. Transcript Can…
ADC Therapeutics Announces Updated LOTIS-2 Results Demonstrating Durable, Long-Term Responses of ZYNLONTA in Relapsed, Refractory DLBCL
Switzerland – ADC Therapeutics SA (NYSE: ADCT) today announced updated results from LOTIS-2, the pivotal Phase 2 clinical trial of ZYNLONTA (loncastuximab tesirine-lpyl) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The data are being presented in a poster today at the European Hematology Association 2023 Hybrid Congress (EHA2023)…
ADC Therapeutics Announces Updated LOTIS-2 Results
LAUSANNE, Switzerland, June 09, 2023 (GLOBE NEWSWIRE) — ADC Therapeutics SA (NYSE: ADCT) today announced updated results from LOTIS-2, the pivotal Phase 2 clinical trial of ZYNLONTA® (loncastuximab tesirine-lpyl) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The data are being presented in a poster today at the European…
ADC Therapeutics (ADCT) Announces Updated LOTIS-2 Results Demonstrating Durable, Long-Term Responses of ZYNLONTA in R/R DLBCL
ADC Therapeutics SA (NYSE: ADCT) today announced updated results from LOTIS-2, the pivotal Phase 2 clinical trial of ZYNLONTA® (loncastuximab tesirine-lpyl) in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). The data are being presented in a poster today at the European Hematology Association 2023 Hybrid Congress (EHA2023) and will…
Aridis Pharmaceuticals Announces First Quarter 2023 Financial Results and Business Update
LOS GATOS, Calif., June 08, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS), a biopharmaceutical company focused on the discovery and development of novel anti-infective therapies for treating life-threatening infections, today reported financial and corporate results for its first quarter ended March 31, 2023. First Quarter & Subsequent Highlights Met…
HEALTH EFFECTS – Toxicological Profile for Phosphate Ester Flame Retardants
To help public health professionals and others address the needs of persons living or working near hazardous waste sites, the information in this section is organized first by route of exposure (inhalation, oral, and dermal) and then by health effect (death, systemic, immunological, neurological, reproductive, developmental, genotoxic, and carcinogenic effects)….
TG Therapeutics Announces Presentation of Data from the
NEW YORK, June 02, 2023 (GLOBE NEWSWIRE) — TG Therapeutics, Inc. (NASDAQ: TGTX), today announced the presentation of data from the ULTIMATE I & II Phase 3 trials evaluating BRIUMVI® (ublituximab-xiiy) in patients with relapsing forms of multiple sclerosis (RMS), at the Consortium of Multiple Sclerosis Centers (CMSC) annual meeting. A link…
2023-06-02 | NDAQ:TGTX | Press Release
NEW YORK, June 02, 2023 (GLOBE NEWSWIRE) — TG Therapeutics, Inc. (NASDAQ: TGTX), today announced the presentation of data from the ULTIMATE I & II Phase 3 trials evaluating BRIUMVI® (ublituximab-xiiy) in patients with relapsing forms of multiple sclerosis (RMS), at the Consortium of Multiple Sclerosis Centers (CMSC) annual meeting….
2023-05-31 | NDAQ:ARDS | Press Release
LOS GATOS, Calif., May 31, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced positive feedback from the FDA on the Company’s proposed single confirmatory Phase 3 study of investigational monoclonal antibody candidate AR-301, which is being developed as an adjunctive therapy in combination with standard of care…
TG Therapeutics (TGTX) Announces Data from ULTIMATE I & II Phase 3 Trials of BRIUMVI in Multiple Sclerosis to be Presented at CMSC
Get inside Wall Street with StreetInsider Premium. Claim your 1-week free trial here. TG Therapeutics, Inc. (NASDAQ: TGTX), today announced the details of an upcoming oral presentation, highlighting data from the ULTIMATE I & II Phase 3 trials evaluating BRIUMVI® (ublituximab-xiiy) in patients with relapsing forms of multiple sclerosis (RMS),…
Aridis Receives Agreement from the FDA on a Single Confirmatory Phase 3 Study of AR-301 and the Clinical Study Design
LOS GATOS, Calif., May 31, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced positive feedback from the FDA on the Company’s proposed single confirmatory Phase 3 study of investigational monoclonal antibody candidate AR-301, which is being developed as an adjunctive therapy in combination with standard of care…
Human Immunodeficiency Virus Related Non-Hodgkin’s Lymphoma
Introduction Human immunodeficiency virus (HIV) infection is associated with an increased risk of hematological malignancy. Lymphoid neoplasms, particularly non-Hodgkin lymphoma, are the main hematologic malignancies that occur more frequently in connection with HIV infection non-Hodgkin lymphoma (NHL).1 Lymphomas are neoplastic lesions of the lymphoid system. According to World Health Organization…
Human T-cell lymphotropic virus type 1 (HTLV-1) proposed vaccines: a systematic review of preclinical and clinical studies | BMC Infectious Diseases
Characteristics of included studies Based on our search, we retrieved 1700 citations. After removing duplicates, a total of 1250 articles were screened based on title and abstract. Furthermore, the hand-searching of other studies revealed 7 studies that met the inclusion criteria and were included after assessing their full texts. Overall,…
Gene Editing of Primary Rhesus Macaque B Cells
We present a method for culturing and gene editing primary rhesus macaque B cells using CRISPR/Cas9 and recombinant adeno-associated virus serotype 6 for the study of B cell therapies. The method is relatively simple and allows efficient gene editing of rhesus macaque B cells. The method allows the testing of…
2023-04-25 | NDAQ:TGTX | Press Release
NEW YORK, April 25, 2023 (GLOBE NEWSWIRE) — TG Therapeutics, Inc. (NASDAQ: TGTX), today announced presentations highlighting data from the ULTIMATE I & II Phase 3 trials evaluating BRIUMVI® (ublituximab-xiiy) in patients with relapsing forms of multiple sclerosis (RMS), at the American Academy of Neurology (AAN) annual meeting. Links to…
Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes
Weber, E. W., Maus, M. V. & Mackall, C. L. The emerging landscape of immune cell therapies. Cell 181, 46–62 (2020). CAS PubMed PubMed Central Google Scholar Eyquem, J. et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature 543, 113–117 (2017). CAS PubMed PubMed…
Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells
Cells Human cervix epitheloid carcinoma HeLa cells (ECACC 93021013; RRID:CVCL_0030) were cultured at 37 °C in Dulbecco′s Modified Eagle′s Medium (DMEM) with 3 mM glutamine, 10% (v/v) fetal calf serum (FCS), 10 mM HEPES, 100 IU/ml penicillin, 100 μg/ml streptomycin, and 5 mM glucose in humidified air with 5% CO2. Human osteosarcoma 143B cells were purchased…
Aridis Provides Corporate Update | India Shorts
LOS GATOS, Calif., March 31, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) (“Aridis” or the “Company”), a biopharmaceutical company, today announced a corporate update on recent developments. The Company received written notice from MedImmune Limited (“MedImmune”) terminating a certain license covering AR-320, a product candidate currently being evaluated for…
Signet ring cell-like diffuse large B-cell lymphoma involving the breast: a case report | BMC Women’s Health
DLBCL is a high-grade lymphoma and the most common type of NHL [4]. DLBCL is highly aggressive, and patients usually present with rapidly expanding lymph nodes and systemic symptoms that require immediate treatment [4]. Although most patients present with swollen lymph nodes, approximately 40% of DLBCL cases arise from extranodal…
DNA origami presenting the receptor binding domain of SARS-CoV-2 elicit robust protective immune response
Reagents, consumables, and kits The oligonucleotides used as primers in the asymmetric polymerase chain reaction (aPCR) and as staple strands for the folding of PB NPs, along with the CpG ODN 1018 adjuvant were purchased from Integrated DNA Technologies (IDT). Fluorescently labelled oligonucleotides used in FRET assay, FAM (donor) and…
Team co-maps proteins and transcriptome in human tissues
Spatial-CITE-seq workflow design and application to diverse mouse tissue types and human tonsil for co-mapping of proteins and whole transcriptome. a, Scheme of spatial-CITE-seq. A cocktail of ADTs is applied to a PFA-fixed tissue section to label a panel of ~200–300 protein markers in situ. Next, a set of DNA…
ADC Therapeutics : Annual Report – Form 6-K
ADC Therapeutics SA 2022 Annual Report Table of Contents Letter to Shareholders Business Update Financial Review Corporate Governance Report from the Auditor on the Consolidated IFRS Financial Statements Consolidated IFRS Financial Statements for the Year Ended December 31, 2022 Report from the Auditor on the Statutory Financial Statements of ADC…
Iconic Technology Group Bioinformatics (CLIA) Developer – Part time
Role: Bioinformatics (CLIA) Developer Location: Remote 1099 / W2 Part time ( 4-10 hours/ week) Qualification : M.S./PhD in Bioinformatics, Bioengineering, Computer Science or related field with 5+ years of experience required Demonstrated bioinformatics pipeline development supporting multiple NGS applications (WGS/WES, RNA-seq, single cell RNA-seq, data automation from sequencer to…
Antibody Response to Omicron Variant Reduced 8 Months After COVID-19 Vaccination
Antibodies against Omicron BA.1 saw a reduction as time went on post vaccination, according to a study published in The Journal of Infectious Diseases. Researchers found that antibody responses to BA.2 and BA.5 were also reduced. Omicron became the dominant variant of concern in December 2021, with 6 infectious subvariants:…
TG Therapeutics Announces Presentation of Data from the ULTIMATE I & II Phase 3 Trials of BRIUMVI By Investing.com
TG Therapeutics, Inc. (NASDAQ:), today announced presentations highlighting data from the ULTIMATE I & II Phase 3 trials evaluating BRIUMVI™ (ublituximab-xiiy) in adult patients with relapsing forms of multiple sclerosis (RMS), presented at the 2023 Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) annual forum. Links to each…
Donor-Derived Staphylococcus Iugdunensis Endocarditis of Transplanted Heart
FINAL DIAGNOSIS Donor-derived Staphylococcus lugdunensis endocarditis of transplanted heart HISTORY OF PRESENT ILLNESS A 56-year-old man presented as a transfer from an outside hospital with cardiogenic shock from nonischemic cardiomyopathy for consideration of advanced therapies. Prior to presentation, he had been experiencing worsening orthopnea, leg swelling, and dyspnea on exertion….
Genotyping approach to predict Coa and Cob antigens
Introduction The Colton (CO) blood group system (ISBT No. 015) currently consists of four antigens; a high prevalence antigen, Coa with its antithetical antigen, Cob, and the other high prevalence antigens, Co3 and Co4.1 The CO antigens are carried on red blood cell (RBC) water transporter, aquaporin-1 (AQP1), encoded by…
Iconic Technology Group Bioinformatics (CLIA) Developer
Role: Bioinformatics (CLIA) Developer Location: Remote W2 / C2C is fine Qualification : M.S./PhD in Bioinformatics, Bioengineering, Computer Science or related field with 5+ years of experience required Demonstrated bioinformatics pipeline development supporting multiple NGS applications (WGS/WES, RNA-seq, single cell RNA-seq, data automation from sequencer to reporting (end-to-end solution) etc)…
TG Therapeutics Announces Data Presentations from the ULTIMATE I & II Phase 3 Trials of … | News
NEW YORK, Feb. 14, 2023 (GLOBE NEWSWIRE) — TG Therapeutics, Inc. (NASDAQ: TGTX), today announced the schedule of data presentations highlighting data from the ULTIMATE I & II Phase 3 trials evaluating BRIUMVI™ (ublituximab) in adult patients with relapsing forms of multiple sclerosis (RMS), at the upcoming Americas Committee for Treatment and…
Iconic Technology Group Bioinformatics Developer
Job Description Role: Bioinformatics Developer Location: Remote W2 / C2C is fine Qualification : M.S./PhD in Bioinformatics, Bioengineering, Computer Science or related field with 5+ years of experience required Demonstrated bioinformatics pipeline development supporting multiple NGS applications (WGS/WES, RNA-seq, single cell RNA-seq, data automation from sequencer to reporting (end-to-end solution)…
Life-threatening pulmonary coinfection with Mycobacterium tuberculosis and Aspergillus lentulus in a diabetic patient diagnosed by metagenome next-generation sequencing | BMC Infectious Diseases
A 79-year-old man was admitted to the cardiology department of our hospital, complaining of a 7-day history of fever, with a temperature up to 39.5 ℃. He denied cough, phlegm, nasal obstruction, pharyngalgia, chest pain, dizziness, or headache. Five days before admission, he was diagnosed with pulmonary infection by chest X-ray…
Omeros: Worst Has Been Priced In, Initiating With A Buy (NASDAQ:OMER)
AsiaVision Background Omeros Corporation (NASDAQ:OMER) is a commercial small-cap biotech based in the US developing several pipelines targeting complement systems. The most advanced indication is Stem-cell transplant-associated TMA (TA-TMA) that already finished pivotal phase 3, atypical hemolytic uremic syndrome (aHUS) is going through phase 3, and IgA nephropathy is currently…
Aridis Reports Top-Line Results of the Phase 3 Double-Blinded, Superiority Trial of AR-301 For the Treatment of Staphylococcus aureus Ventilator Associated Pneumonia (VAP)
Aridis Pharmaceuticals, Inc. LOS GATOS, Calif, Jan. 25, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced top-line results from the AR-301-002 Phase 3 study, which evaluated the superiority of adjunctive use of the investigational monoclonal antibody candidate AR-301 with standard of care (SOC) antibiotics versus SOC antibiotics…
Aridis Reports Top-Line Results of the Phase 3
LOS GATOS, Calif, Jan. 25, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced top-line results from the AR-301-002 Phase 3 study, which evaluated the superiority of adjunctive use of the investigational monoclonal antibody candidate AR-301 with standard of care (SOC) antibiotics versus SOC antibiotics alone, for the…
Novel Agents Replace CAR T-Cell Therapy in Later-Line, Relapsed/Refractory DLBCL
New treatments are emerging for patients with relapsed/refractory diffuse large B-cell lymphoma in addition to chimeric antigen receptor T-cell therapy, which has moved up into the second line. New treatments are emerging for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) in addition to chimeric antigen receptor (CAR) T-cell therapy,…
Senior Clinical Bioinformatics Scientist – Medical Center, New York, United States
Senior Clinical Bioinformatics Scientist 525626 Medical Center Institute for Genomic Medicine Full Time Grade 104 Job Type: Officer of Administration Bargaining Unit: Regular/Temporary: Regular End Date if Temporary: Hours Per Week: 35 Salary Range: Position Summary The Precision Genomics Laboratory (PGL), a partnership between the Department of Pathology and…
An in silico approach to study the role of epitope order in the multi-epitope-based peptide (MEBP) vaccine design
The purpose of a vaccine (MEBPVC in the current context) is to elicit a strong response from the host immune system against a disease (COVID-19) releasing various neutralizing antibodies which continue to stay in the body to protect the host from any repeat infection thenceforth. Toll-like receptors (TLRs) are the…
A Differential Immune Regulatory Role of EGR2 in B6/lpr Versus Normal B6 Mice.docx
Previous studies have reported that deletion of the transcription factor, early growth response protein 2 (EGR2), in normal C57BL/6 (B6) resulted in the development of lupus-like autoimmune disease. However, increased EGR2 expression has been noted in human and murine lupus, which challenges the notion of the autoimmune suppressive role of…
COVID-19 vaccines in liver transplant recipients
Introduction Three waves of world wild emerging severe infectious disease pandemics have been presented during this century because of the coronavirus. The severe acute respiratory syndrome (SARS) outbreak in southern China since 2002 has spread to 8096 cases from 29 countries, with a mortality of 9.6%.1 Middle East respiratory syndrome…
An Introduction to the Biopharmaceutical Industry – Features
David Gemmell looks at key unit operations, and why chemical engineers are heavily involved in their design, troubleshooting or optimisation TO DATE, the Covid-19 pandemic has taken the lives of over 5.7m1 people and impacted global trade, travel, and the livelihoods of billions. It also sparked a vaccine…
Rat Anti-Mouse CD25/IL-2R Antibody
Name Rat Anti-Mouse CD25/IL-2R Antibody (GWB-31929F) Related Product Names Rat Anti-Mouse CD25/IL-2Ra-PE; PMP-22; Protein CD25; SR13 myelin protein; Schwann cell membrane glycoprotein; SAG Cd25; Pmp-22Rat Anti-Mouse CD25/IL-2RPmp22 Gene Symbol IL2RA Gene Fullname Interleukin-2 receptor subunit alpha Gene id 3559 Swissprot ID P01589 Protein Name Interleukin-2 receptor subunit alpha Protein Accession…
A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors
Cell lines and culture Unless stated otherwise, all tumor target cell lines were sourced from the ATCC via LGC Standards. Human endogenous mesothelin (MSLN)-positive target cell lines H-226 (lung carcinoma, MSLN+, ATCC® CRL-5826™) and AsPC-1 (ATCC CRL-1682), and MSLN-negative Raji control cells (ATCC CCL-86) were cultured in RPMI-1640 Glutamax (Life Technologies,…
Valine feeding reduces ammonia production through rearrangement of metabolic fluxes in central carbon metabolism of CHO cells
Aghamohseni H, Ohadi K, Spearman M, Krahn N, Moo-Young M, Scharer JM, Butler M, Budman HM (2014) Effects of nutrient levels and average culture pH on the glycosylation pattern of camelid-humanized monoclonal antibody. J Biotechnol 186:98–109. doi.org/10.1016/j.jbiotec.2014.05.024 CAS Article PubMed Google Scholar Altamirano C, Illanes A, Casablancas A, Gámez X,…
IRE combined with toripalimab versus IRE alone for LAPC
Introduction Pancreatic ductal adenocarcinoma (PDAC) is a lethal gastrointestinal disease with increasing morbidity, which also has a growing impact on cancer-specific mortality worldwide.1 Nearly 40% of all PDAC cases are localized to the pancreas and characterized with the involvement of major vascular structures, leading to unresectable disease without metastases detected…
Identification of immunodominant Bartonella bacilliformis proteins: a combined in-silico and serology approach
Introduction Carrión’s disease is a vector-borne biphasic illness restricted to the South American Andes, with Peru as the most affected country. 1 Gomes C Pons MJ Del Valle Mendoza J Ruiz J Carrion’s disease: an eradicable illness?. The causative agent, Bartonella bacilliformis, is transmitted to humans by sandflies (Lutzomyia spp)….