Tag: iPSCs

This startup wants you to have a personal stem cell stash

Salvatore Viscomi always wanted to be involved in a science fiction project — and he found one. Viscomi is the chief medical officer of GoodCell, a Massachusetts-based startup where people can bank their own white blood cells with a simple blood draw. Labs can then tweak those cells to become…

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Induzierte pluripotente Stammzellen (IPSCs) Marktanteil, Analyse der wichtigsten Wettbewerber, Prognose bis 2028

Der Induzierte pluripotente Stammzellen (IPSCs) Market“-Forschungsbericht umfasst umfassende Daten zu vorherrschenden Trends, Treibern, Wachstumschancen und Einschränkungen, die die marktverändernden Aspekte der globalen Industrie variieren können. Dieser Bericht bietet eine eingehende Analyse der Marktsegmentierung, die Produkte, Anwendungen und geografische Analysen enthält. Der globale Induzierte pluripotente Stammzellen (IPSCs)-Marktbericht bietet eine genaue Beobachtung…

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Tumorigenicity risk of iPSCs in vivo: nip it in the bud

Review . 2022 Feb 3;5(1):pbac004. doi: 10.1093/pcmedi/pbac004. eCollection 2022 Mar. Affiliations Expand Affiliations 1 Department of Cell Biology, Naval Medical University, Shanghai 200433, China. 2 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University,…

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CENTURY THERAPEUTICS, INC. Management’s discussion and analysis of financial condition and results of operations (form 10-Q)

The following discussion and analysis should be read in conjunction with our financial statements and accompanying notes included in this Quarterly Report on Form 10-Q and the financial statements and accompanying notes thereto for the fiscal year ended December 31, 2021 and the related Management’s Discussion and Analysis of Financial…

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Orgenesis Led Consortium awarded EUR 4M European Innovation Council Pathfinder Grant

Focus is to develop cost-effective production of autologous induced pluripotent stem cells (iPSCs) using microfluidic technologies and artificial intelligence (AI) Germantown, Maryland, USA, May 3, 2022 – Orgenesis Inc. (NASDAQ: ORGS) (“Orgenesis” or the “Company”), a global biotech company working to unlock the full potential of cell and gene therapies, today announces a consortium…

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Human stem cell modelling for heart disease of long QT syndrome

Abstract Sudden cardiac death (SCD) in otherwise healthy young people is a public health priority. Long QT syndrome (LQTS) is the commonest life-threatening cardiac arrhythmia contributing to SCD under 40 years old with an estimated prevalence of 1:2,000. Cardiac rhythm is driven by coordinated cardiac action potential, which is triggered…

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TREEFROG THERAPEUTICS LAUNCHES A $100,000 RESEARCH GRANT IN REGENERATIVE MEDICINE

Bordeaux, France / April 19th, 2022 – TreeFrog Therapeutics, a biotechnology company aimed at making safer, more efficient and more affordable cell therapies based on induced pluripotent stem cells (iPSCs), today announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell…

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Building better models of brain aging and Alzheimer’s disease

Every moment counts in the pursuit of effective preventions and treatments for age-associated diseases affecting the brain. Capturing the essence of how aging and dementias such as Alzheimer’s disease affect the brain without the need to wait for aging to take place in real time has been a long-standing obstacle…

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Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules

Li, Zhang, Yin, Yang, Du, Hou, Ge, Liu, Zhang, Zhang, Wu, Li, Liu, Wu, Song, Zhao, Shi, Deng (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules Cell Res 21(1) 196-204 Full text Abstract The introduction of four transcription factors Oct4,…

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Solved Question 14 1 pts Hirschsprung disease (aka

Transcribed image text: Question 14 1 pts Hirschsprung disease (aka congenital aganglionic megacolon) stems from a failure of enteric nervous system (ENS) innervation of the distal colon resulting in the inability to pass stool. Scientists studying this disease are interested in modeling the ENS in culture beginning with human iPSCs….

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Postdoc – Human Genome Engineering, Cell Therapies, iPSCs, Synthetic Biology

The Truong lab is hiring for multiple Postdoctoral Fellow positions at NYU. We use large scale human genome engineering to develop off-the-shelf cell therapies using iPSCs.   The lab uses Synthetic Biology to build allogeneic Dendritic Cells from iPSCs as a platform for cell immunotherapies. We are interested in all…

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Researchers identify sustainable source of im

image: Monkey iPSCs with edited CCR5 locus growing in culture. view more  Credit: Image Credit: Saritha D’Souza, Wisconsin National Primate Research Center, USA Genetic engineering can make immune cells resistant to infection with human or monkey (simian) immunodeficiency virus (HIV and SIV, respectively). Recently, treatment with HIV-resistant immune cells has given…

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Modeling the Human Brain with Organoids

iPSCs As Models, Part 2: Modeling the Human Brain with Organoids The store will not work correctly in the case when cookies are disabled. JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript…

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One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors

Introduction of CRX and NEUROD1 using piggyBac vector into iPSCs and differentiation to induced photoreceptor-like cells (iPRCs) (A) Design of polycistronic piggyBac vector for CRX and NEUROD1 mediated conversion under control of the tetracycline operator rtTA and neomycin resistance gene. Dox: doxycycline, rtTA: reverse tetracycline transactivator, neo: neomycin resistance gene….

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Regenerative therapies with induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) are a type of stem cell with pluripotent characteristics. That is, they have the capacity to generate most of the tissues and cells of all adult cell types. They are obtained artificially from a cell that was initially not pluripotent. Due…

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Cutting Edge Agriculture Gene Editing with Cas-CLOVER

Blog Agriculture Biotechnology Though CRISPR-Cas enabled targeted genome engineering across a vast array of organisms, the system features major disadvantages. Frequent off-target mutagenesis, licensing restrictions and non-ideal economic license terms have inhibited commercial crop-science product upscaling, and, in many cases, entirely disqualified CRISPR’s use by many commercial crop developers. Seeking…

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A hydrogel-based 3D culture model for Down syndrome-myeloid leukemia and ex vivo drug testing

Abstract Induced pluripotent stem cells (iPSCs) provide an extraordinary tool for disease modeling owing to their potential to differentiate into the desired cell type. The differentiation of iPSCs is typically performed on 2-dimensional monolayers of stromal cell or animal tissue derived extracellular matrices. Recent advancements in disease modeling have utilized…

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Endothelial Cell Differentiation from iPSCs – iPSC Differentiation Service – Stem Cell Services – Service – Research

iPSC-Derived Endothelial Cells Optimized iPSC Generation & Differentiation Protocols High Purity & Well Characterized iPSC-derived endothelial cells (EC) are valuable tools that can help researchers better understand vascular diseases. At ASC, we use a fast, cost-effective differentiation procedure that allows our team to deliver high-quality cells in…

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Precision Control of Culture Conditions for Induced Pluripotent Stem Cells

By Sally Temple The Nobel Prize–winning discovery that mature, specialized cells can be reprogrammed to lend them pluripotency (that is, the ability to develop into all tissues of the body) unleashed vast potential in the fields of disease modeling, drug screening, regenerative medicine, and wound healing. The reprogrammed cells are…

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Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells

doi.org/10.1016/j.ymgmr.2022.100852Get rights and content Highlights • We generated induced pluripotent stem cells (iPSCs) from two late-infantile MLD patient-derived skin fibroblasts. • We differentiated MLD phenotype specific motor neurons (MNs) under the culture condition. • We described the pathological observation of MLD patients derived motor neuron progenitors (MNPs). • We described…

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Science Papers on Spatial Characterization of Sensory Neurons, Megakaryocyte Differentiation Mapping

A spatial transcriptomic analysis of key human sensory neurons is presented in Science Translational Medicine this week, uncovering potential new drug targets for pain management. Despite the significant medical problem pain represents, there has been little progress translating preclinical work on peripheral pain mechanisms, which has largely been done in rodents,…

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CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy

Ishino Y, Shinagawa H, Makino K, et al. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol. 1987;169:5429–33. CAS  PubMed  PubMed Central  Google Scholar  Jansen R, van Embden JDA, Gaastra W, et al. Identification of genes…

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Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection

INTRODUCTION Dengue is the most common mosquito-borne viral disease globally (1). This acute disease, which can be life-threatening, is caused by four different dengue viruses (DENVs) (DENV-1, DENV-2, DENV-3, and DENV-4). An estimated 390 million people are infected with these DENVs annually (2), and populations throughout the tropics face frequent…

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Generation of NKX2.5 GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts

doi: 10.3389/fcell.2021.797927. eCollection 2021. Leyre López-Muneta  1 , Javier Linares  1 , Oscar Casis  2 , Laura Martínez-Ibáñez  3 , Arantxa González Miqueo  3   4 , Jaione Bezunartea  5 , Ana Maria Sanchez de la Nava  6   7 , Mónica Gallego  2 , María Eugenia Fernández-Santos  6   7 , Juan Roberto Rodriguez-Madoz  8 , Xabier L Aranguren …

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Creative Bioarray Built Professional Cell Reprogramming Services with Cutting-edge Technologies to Accelerate Drug Development and Research

Creative Bioarray announced the release of its professional cell reprogramming services with cutting-edge technologies to accelerate drug development and research. New York, USA – January 24, 2022 – Cell culture platform, the division of Creative Bioarray, focuses on developing complete cell culture solutions with plenty of choices for the next…

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PostDoc iPSCs for toxicology (m/w/d) – Biberach

OUR COMPANY At Boehringer Ingelheim we develop breakthrough therapies and innovative healthcare solutions in areas of unmet medical need for both humans and animals. As a family owned company, we focus on long-term performance. We believe that, if we have talented and ambitious people who are passionate about innovation, there…

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Pluristyx, panCELLa, and Implant Therapeutics Announce a Strategic Alliance to Manufacture and Distribute Genetically Modified, Clinical-grade Human-induced Pluripotent Stem Cells

SEATTLE–(BUSINESS WIRE)–Pluristyx, Inc., an advanced therapy tools and services biotechnology company, panCELLa, a privately held biotechnology company, and Implant Therapeutics, a developer of genetically engineered stem cells, today announced they have entered into a manufacturing and distribution strategic alliance that offers cell therapy companies streamlined access to the next generation…

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Applications of iPSCs in Gaucher Disease and other rare sphingolipidoses

Chapter contents Book contents Volume 16 in Advances in Stem Cell Biology 2022, Pages 197-224 doi.org/10.1016/B978-0-323-85767-3.00001-3Get rights and content Abstract In this chapter, an overview of various applications of induced pluripotent cells (iPSCs) is given. This chapter focuses on the uses of iPSCs in inherited diseases and, particularly, in the…

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Generation of a human iPSC line CIPi001-A from a benign familial infantile epilepsy patient related 16p11.2 deletion

doi.org/10.1016/j.scr.2021.102634Get rights and content Abstract The features of 16p11.2 deletion phenotype is developmental delay, intellectual disability, and autism spectrum disorder. Seizures are observed in approximately 20% of individuals with the microdeletion. Induced pluripotent stem cells (iPSCs) were generated from erythroblasts obtained from a child diagnosed with benign familial infantile epilepsy,…

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NIH researchers develop first stem cell model of albinism to study related eye conditions

News Release Tuesday, January 11, 2022 Use of patient-derived stem cells will enable high-throughput drug screening for potential therapeutics. Researchers at the National Eye Institute (NEI) have developed the first patient-derived stem cell model for studying eye conditions related to oculocutaneous albinism (OCA). The model’s development is described in…

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Applications of human iPSCs for disease modeling and screening

The development of physiologically relevant human models for neurological diseases remains a challenge for pre-clinical drug discovery. With the emergence of human induced pluripotent stem cell (hiPSC) technology, it is now possible to design and manufacture cell types that are critical players in neural disease pathogenesis, such as neurons, astrocytes…

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Rare Diseases Are Focus of Latest Yale Journal of Biology and Medicine

The Yale Journal of Biology and Medicine’s (YJBM’s) December 2021 issue on rare disease has been published on PubMed Central. This focus issue features articles on just a few of the estimated 7,000 rare diseases people in the world experience. As we get closer to Rare Disease Day on February…

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Citius Pharmaceuticals, Inc. to Present at Upcoming Virtual Conferences

H.C. Wainwright BioConnect 2022 Conference January 10-13, 2022 Biotech Showcase Virtual Conference January 17-19, 2022 CRANFORD, N.J., Jan. 4, 2022 /PRNewswire/ — Citius Pharmaceuticals, Inc. (“Citius” or the “Company”) (Nasdaq: CTXR), a late-stage biopharmaceutical company dedicated to the development and commercialization of first-in-class critical care products with a focus on…

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Investigating changes in the proteostasis capabilities of iPSC-neurons during development and in FTD using iPSC-neurons with MAPT mutations

This article was originally published here Alzheimers Dement. 2021 Dec;17 Suppl 2:e058308. doi: 10.1002/alz.058308. ABSTRACT BACKGROUND: Mutations in microtubule-associated protein tau (MAPT) gene are causative of Frontotemporal Dementia (FTD). Many of the features associated with the development of tau pathology, e.g high levels of tau phosphorylation, are also present in…

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Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients

Figure 6 Dynamics of pluripotent and germ cells markers during hPGCLCs -TS induction. ( A… Figure 6 Dynamics of pluripotent and germ cells markers during hPGCLCs -TS induction. (A) Schematic protocol used to generate hPGCLCs. (B) hiPSCs-TS (p20), hEpiLC-TS (D.2), and hPGCLCs-TS (D.6) quantification of the relative expression of OCT4,…

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iPSCs and DRGs: stepping stones to new pain therapies

doi.org/10.1016/j.molmed.2021.11.005Get rights and content Highlights Voltage-gated sodium (NaV) channels are key drivers of pain in humans and contribute to neuronal excitability and have been regarded as opportune therapeutic targets. The limited success of developing pain therapies targeting NaV channels may reflect the limitations of preclinical screening systems, as heterologous cell…

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Rapid generation of ventral spinal cord-like astrocytes from human iPSCs for modeling non-cell autonomous mechanisms of lower motor neuron disease

Abstract Background: Astrocytes play important roles in the function and survival of neuronal cells. Dysfunctions of astrocytes are associated with numerous disorders and diseases of the nervous system, including motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Human induced pluripotent stem cell (iPSC)-based approaches are becoming increasingly important for…

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Fate Therapeutics Highlights Positive Durability of

6 of 10 Patients Naïve to Treatment with Autologous CAR T-cell Therapy Continue in Ongoing Response at Median Follow-up of 9.1 Months, including 4 Patients with >6 Months Follow-up, at ≥90 Million FT516 Cells per Dose 3 of 8 Patients Previously Treated with Autologous CAR T-cell Therapy Achieve Complete Response…

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Induced Pluripotent Stem Cells Detection via Ensemble Yolo Network

Induced pluripotent stem cells (iPSCs) have huge potential in regenerative medicine research and industrial applications. However, building automatic method without using cell staining technique for iPSCs identification is an important challenge. To improve the efficiency of producing iPSCs, we build an accurate and noninvasive iPSCs colonies detection method via ensemble…

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Stomach organoid created from multiple stem cell types | 2021-12-10

A group of scientists at the Cincinnati Children’s Hospital has used separate lines of human induced pluripotent stem cells (iPSCs) to create stomach organoids with a three-layered structure and gastric function such as smooth muscle contraction and glandular secretion. The team reported its results in the December 2021, issue of…

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An Optimized Culture Medium for Induced Pluripotent Stem Cells

In 2006, Kazutoshi Takahashi and Shinya Yamanaka made a revolutionary breakthrough when they reprogrammed terminally differentiated, lineage-restricted adult somatic cells into a pluripotent state via the expression of transcription factors Oct4, Sox2, Klf4, and c-Myc.1 Now, researchers can differentiate reprogrammed induced pluripotent stem cells (iPSCs) into any cell type and…

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Doctoral student finds alternative cell option for organs-on-chips — ScienceDaily

Organ-on-a-chip technology has provided a push to discover new drugs for a variety of rare and ignored diseases for which current models either don’t exist or lack precision. In particular, these platforms can include the cells of a patient, thus resulting in patient-specific discovery. As an example, even though sickle…

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Researchers Make New iPSC Models of Friedreich’s Ataxia

A team of scientists at Koc University in Turkey has created three new cell models of Friedreich’s ataxia (FA) derived from patients with repeat expansions in their FXN gene. The models “will facilitate studies to understand molecular mechanisms related to FRDA [Friedreich’s ataxia] pathology [disease processes] as well as therapeutic investigations…

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MD Anderson research highlights 9 December

ATLANTA ― The University of Texas MD Anderson Cancer Center‘s Research Highlights provides a glimpse into basic, translational and clinical cancer research from MD Anderson experts. This special edition features presentations at the 2021 American Society of Hematology (ASH) Annual Meeting on innovative targeted therapies, new combination approaches, and novel…

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Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant

Abstract With the wide adoption of genomic sequencing in children having seizures, an increasing number of SCN2A genetic variants have been revealed as genetic causes of epilepsy. Voltage-gated sodium channel Nav1.2, encoded by gene SCN2A, is predominantly expressed in the pyramidal excitatory neurons and supports action potential (AP) firing. One…

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How Artificial Intelligence Can Be Used To Augment Stem Cell Therapy In Hospitals

Stem cell therapy comes with its own set of challenges despite being a revolutionary discovery in modern healthcare. As we know, AI has several applications in the deep and diverse field of healthcare. So, stem cell AI’s incredible capabilities can overcome those challenges and truly improve stem cell therapy in…

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Scientific webinars on SelectScience

Genome engineering has revolutionized medical research through the ability to precisely edit the DNA sequence of cells. In combination with human induced pluripotent stem cells (hiPSCs), editing the genome can provide unprecedented insight into disease-causing mechanisms on a patient and tissue-specific basis. A major challenge, however, is the efficient generation…

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CRISPR-Engineered Cells Release Drug in Response to Inflammation When Implanted into Mice

Source: Science Photo Library/Getty Images Researchers at Washington University School of Medicine in St. Louis have used CRISPR-Cas9 genome editing to engineer induced pluripotent stem cells (iPSCs) that can be implanted subcutaneously to deliver an anticytokine biologic drug in response to inflammation caused by rheumatoid arthritis. When implanted into a…

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New Techniques and Complex Models

CRISPR systems that rely on inactivated Cas enzymes—that is, dead Cas (dCas) enzymes—never looked more alive. They harness the targeting power associated with CRISPR—but not the double-strand cuts. As such, they give researchers new ways to interrogate and manipulate gene function. Possibilities include CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa)…

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Editas Medicine Presents Data on New SLEEK Gene Editing

SLEEK enables high efficiency, multi-transgene knock-in of induced Pluripotent Stem Cells (iPSCs), T cells, and Natural Killer (NK) cells Data support SLEEK as an optimized approach to develop next generation cell therapy medicines CAMBRIDGE, Mass., Aug. 20, 2021 (GLOBE NEWSWIRE) — Editas Medicine, Inc. (Nasdaq: EDIT), a leading genome editing company, today…

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Python fast way to get ONLY MAIN metadata for GSE ? (not walking through thousands underlying GSM-samples : slow or even endless)

  Not Python but using EntrezDirect you can get: $ esearch -db bioproject -query “GSE118723” | esummary | xtract -pattern DocumentSummary -element Project_Description Quantification of gene expression levels at the single cell level has revealed that gene expression can vary substantially even across a population of homogeneous cells. However, it…

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