Tag: iPSCs

What Is Stem Cell Research?

There are cells within our bodies that have a spectacular power. Known as stem cells, they build our bodies before we’re born and regenerate our tissues to keep us alive. For example, stem cells in the skin help us heal from cuts and other stem cells deep in the bone…

Continue Reading What Is Stem Cell Research?

Therapeutic Solutions International Announces Launch of Cancer Immunotherapy Spin-Off Res Nova Bio, Inc.

Company to Develop StemVacs-V Anti-Angiogenesis Immunotherapy for Initial Treatment of Breast Cancer ELK CITY, Idaho, October 27, 2022–(BUSINESS WIRE)–Therapeutic Solutions International (TSOI) announced today formation of a Spin-Off Company, Res Nova Bio, Inc., dedicated to the development of cancer inhibiting anti-angiogenesis immunotherapies. Res Nova Bio has licensed from Therapeutic Solutions…

Continue Reading Therapeutic Solutions International Announces Launch of Cancer Immunotherapy Spin-Off Res Nova Bio, Inc.

BU researcher receives BrightFocus Award

(Boston)—Julia TCW, PhD, assistant professor of pharmacology & experimental therapeutics at Boston University Chobanian & Avedisian School of Medicine, has received a three-year, $300,000 grant from the BrightFocus Foundation. The award will fund her research project, “Modulation of astrocyte matrisome signals reprogram microglia that can be targeted to mitigate Alzheimer’s…

Continue Reading BU researcher receives BrightFocus Award

Modelling urea cycle disorders using iPSCs

Gebhardt, R. & Matz-Soja, M. Liver zonation: Novel aspects of its regulation and its impact on homeostasis. World J. Gastroenterol. 20, 8491–8504 (2014). PubMed  PubMed Central  Article  Google Scholar  Summar, M. L. et al. The incidence of urea cycle disorders. Mol. Genet Metab. 110, 179–180 (2013). CAS  PubMed  PubMed Central …

Continue Reading Modelling urea cycle disorders using iPSCs

Aged neurons generated directly from skin more accurately model Parkinson’s disease

Induced dopaminergic neurons directly reprogrammed from the skin cells of a patient with idiopathic Parkinson’s Disease. Credit: Janelle Drouin-Ouellet, University of Montreal, Canada The possibility to make virtually all cell types of the human body from induced pluripotent stem cells (iPSCs), which are embryonic-like cells generated from a patient’s skin,…

Continue Reading Aged neurons generated directly from skin more accurately model Parkinson’s disease

Manufacturing GMP-compliant iPSCs in closed and open systems

Webinar Human pluripotent stem cells (PSCs) and their derivatives hold great potential in regenerative cell therapies, and recently have been used in a number of clinical trials targeting various diseases. In this webinar, Dr. Dhruv Sareen (Executive Director, Cedars-Sinai Biomanufacturing Center) will introduce the Cedars-Sinai Biomanufacturing Center, a leading…

Continue Reading Manufacturing GMP-compliant iPSCs in closed and open systems

Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells

%PDF-1.4 % 1 0 obj > endobj 2 0 obj >stream 2022-07-17T07:34:20 Adobe InDesign 15.0 (Windows) 2022-07-18T08:10:34+02:00 2022-07-18T08:10:34+02:00 Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Macrophage;iPSCs;Cardiac differentiation;Inflammation False application/pdf doi.org/10.1186/s12964-022-00916-1 BioMed Central Cell Communication and Signaling, doi.org/10.1186/s12964-022-00916-1 Macrophage iPSCs Cardiac differentiation Inflammation…

Continue Reading Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells

Global iPSCs Manufacturing Services Market Research Insight 2022

Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis Cholinergic dysfunction has been implicated in the pathophysiology of psychosis and psychiatric disorders such as schizophrenia, depression, and bipolar disorder. The basal forebrain (BF) cholinergic nuclei, defined as cholinergic cell groups Ch1-3 and Ch4 (Nucleus Basalis of Meynert; NBM),…

Continue Reading Global iPSCs Manufacturing Services Market Research Insight 2022

Laverock Therapeutics founded to develop the next generation of programmable cell therapies

Stevenage, UK, 31st August 2022 / Sciad Newswire / Laverock Therapeutics Ltd was founded to develop a unique gene silencing platform for the creation of programmable, allogeneic cell therapies. Having recently completed a seed funding round, the Company has opened dedicated labs in the Stevenage Bioscience Catalyst, employing six new team members on top of…

Continue Reading Laverock Therapeutics founded to develop the next generation of programmable cell therapies

iPSCs derived from infertile men carrying complex genetic abnormalities can generate primordial germ-like cells

Patients and controls The patient 1 was 38 years old and consulted for infertility after he and his partner had been trying to conceive for 2 years. The patient was the first child of unrelated parents, and he had four brothers and five sisters whose fertility status could not be determined…

Continue Reading iPSCs derived from infertile men carrying complex genetic abnormalities can generate primordial germ-like cells

iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion

Background: The genetic factors associated with insulin resistance (IR) are not well understood. Clinical studies on first-degree relatives of type 2 diabetic (T2D) patients, which have the highest genetic predisposition to T2D, have given insights into the role of IR in T2D pathogenesis. Induced pluripotent stem cells (iPSCs) are excellent…

Continue Reading iPSCs derived from insulin resistant offspring of type 2 diabetic patients show increased oxidative stress and lactate secretion

Scientists discover a technique to restore some diseased cells to their proper state

Scientists developed a novel screening methodology for identifying genes that regulate specific microglial functions that may contribute to Alzheimer’s disease (AD) in a recent article published inNature Neuroscience. Characterizing regulatory genes that cause microglia to shift from a healthy state to a diseased state, such as in the brains of…

Continue Reading Scientists discover a technique to restore some diseased cells to their proper state

iPSCs – Pharmacology Group Discussion

iPSCs – Pharmacology Group Discussion – HackMD       Published Linked with GitHub # iPSCs – Pharmacology Group Discussion ## Neurology ### Reviews * [パーキンソン病に対する多能性幹細胞を用いた細胞移植治療の現状](https://doi.org/10.5692/clinicalneurol.cn-001235) * pdf * www.jstage.jst.go.jp/article/clinicalneurol/59/3/59_cn-001235/_article/-char/ja/ * doi * doi.org/10.5692/clinicalneurol.cn-001235 ### Trials * [Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised,…

Continue Reading iPSCs – Pharmacology Group Discussion

Recent Advances in 3D-Cultured Brain Tissue Models Derived from Human iPSCs

Heffernan, A.L., Hare, D.J.: Tracing environmental exposure from neurodevelopment to neurodegeneration. Trends Neurosci. 41, 496–501 (2018) CAS  PubMed  Article  Google Scholar  Pacitti, D., Privolizzi, R., Bax, B.E.: Organs to cells and cells to organoids: the evolution of in vitro central nervous system modelling. Front Cell Neurosci. 13, 129 (2019) CAS …

Continue Reading Recent Advances in 3D-Cultured Brain Tissue Models Derived from Human iPSCs

Reconstructing How the Spine Takes its Shape

Marina Sanaki-Matsumiya, PhDPostdoctoral FellowLaboratory of Synthetic Developmental BiologyEuropean Molecular Biology Laboratory (EMBL), Barcelona For as long as she can remember, Marina Sanaki-Matsumiya wanted to understand the mechanisms shaping the bones that form our skeletons. Born with a genetic skeletal disease, the developmental biologist first established an in vitro model to…

Continue Reading Reconstructing How the Spine Takes its Shape

Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells | BMC Molecular and Cell Biology

Lubricin is believed to be an effective therapeutic agent for osteoarthritis and synovitis. However, clinical application of recombinant or synthesised lubricin has not been attempted yet. In this study, we successfully developed a protocol to induce lubricin-expressing cells from pluripotent stem cells and confirmed their differentiation into Prg4-expressing cells that…

Continue Reading Induction of iPSC-derived Prg4-positive cells with characteristics of superficial zone chondrocytes and fibroblast-like synovial cells | BMC Molecular and Cell Biology

Researchers Grow Stem Cells Aboard International Space Station In New Study

Scientists are growing stem cells in space in an effort to discover new ways to produce large batches of certain stem cells to treat a variety of diseases. Researchers from Cedars-Sinai Medical Center in Los Angeles are behind the program that delivered stem cells to the International Space Station (ISS)…

Continue Reading Researchers Grow Stem Cells Aboard International Space Station In New Study

This startup wants you to have a personal stem cell stash

Salvatore Viscomi always wanted to be involved in a science fiction project — and he found one. Viscomi is the chief medical officer of GoodCell, a Massachusetts-based startup where people can bank their own white blood cells with a simple blood draw. Labs can then tweak those cells to become…

Continue Reading This startup wants you to have a personal stem cell stash

Induzierte pluripotente Stammzellen (IPSCs) Marktanteil, Analyse der wichtigsten Wettbewerber, Prognose bis 2028

Der Induzierte pluripotente Stammzellen (IPSCs) Market“-Forschungsbericht umfasst umfassende Daten zu vorherrschenden Trends, Treibern, Wachstumschancen und Einschränkungen, die die marktverändernden Aspekte der globalen Industrie variieren können. Dieser Bericht bietet eine eingehende Analyse der Marktsegmentierung, die Produkte, Anwendungen und geografische Analysen enthält. Der globale Induzierte pluripotente Stammzellen (IPSCs)-Marktbericht bietet eine genaue Beobachtung…

Continue Reading Induzierte pluripotente Stammzellen (IPSCs) Marktanteil, Analyse der wichtigsten Wettbewerber, Prognose bis 2028

Tumorigenicity risk of iPSCs in vivo: nip it in the bud

Review . 2022 Feb 3;5(1):pbac004. doi: 10.1093/pcmedi/pbac004. eCollection 2022 Mar. Affiliations Expand Affiliations 1 Department of Cell Biology, Naval Medical University, Shanghai 200433, China. 2 Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University,…

Continue Reading Tumorigenicity risk of iPSCs in vivo: nip it in the bud

CENTURY THERAPEUTICS, INC. Management’s discussion and analysis of financial condition and results of operations (form 10-Q)

The following discussion and analysis should be read in conjunction with our financial statements and accompanying notes included in this Quarterly Report on Form 10-Q and the financial statements and accompanying notes thereto for the fiscal year ended December 31, 2021 and the related Management’s Discussion and Analysis of Financial…

Continue Reading CENTURY THERAPEUTICS, INC. Management’s discussion and analysis of financial condition and results of operations (form 10-Q)

Orgenesis Led Consortium awarded EUR 4M European Innovation Council Pathfinder Grant

Focus is to develop cost-effective production of autologous induced pluripotent stem cells (iPSCs) using microfluidic technologies and artificial intelligence (AI) Germantown, Maryland, USA, May 3, 2022 – Orgenesis Inc. (NASDAQ: ORGS) (“Orgenesis” or the “Company”), a global biotech company working to unlock the full potential of cell and gene therapies, today announces a consortium…

Continue Reading Orgenesis Led Consortium awarded EUR 4M European Innovation Council Pathfinder Grant

Human stem cell modelling for heart disease of long QT syndrome

Abstract Sudden cardiac death (SCD) in otherwise healthy young people is a public health priority. Long QT syndrome (LQTS) is the commonest life-threatening cardiac arrhythmia contributing to SCD under 40 years old with an estimated prevalence of 1:2,000. Cardiac rhythm is driven by coordinated cardiac action potential, which is triggered…

Continue Reading Human stem cell modelling for heart disease of long QT syndrome

TREEFROG THERAPEUTICS LAUNCHES A $100,000 RESEARCH GRANT IN REGENERATIVE MEDICINE

Bordeaux, France / April 19th, 2022 – TreeFrog Therapeutics, a biotechnology company aimed at making safer, more efficient and more affordable cell therapies based on induced pluripotent stem cells (iPSCs), today announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell…

Continue Reading TREEFROG THERAPEUTICS LAUNCHES A $100,000 RESEARCH GRANT IN REGENERATIVE MEDICINE

Building better models of brain aging and Alzheimer’s disease

Every moment counts in the pursuit of effective preventions and treatments for age-associated diseases affecting the brain. Capturing the essence of how aging and dementias such as Alzheimer’s disease affect the brain without the need to wait for aging to take place in real time has been a long-standing obstacle…

Continue Reading Building better models of brain aging and Alzheimer’s disease

Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules

Li, Zhang, Yin, Yang, Du, Hou, Ge, Liu, Zhang, Zhang, Wu, Li, Liu, Wu, Song, Zhao, Shi, Deng (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules Cell Res 21(1) 196-204 Full text Abstract The introduction of four transcription factors Oct4,…

Continue Reading Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules

Solved Question 14 1 pts Hirschsprung disease (aka

Transcribed image text: Question 14 1 pts Hirschsprung disease (aka congenital aganglionic megacolon) stems from a failure of enteric nervous system (ENS) innervation of the distal colon resulting in the inability to pass stool. Scientists studying this disease are interested in modeling the ENS in culture beginning with human iPSCs….

Continue Reading Solved Question 14 1 pts Hirschsprung disease (aka

Postdoc – Human Genome Engineering, Cell Therapies, iPSCs, Synthetic Biology

The Truong lab is hiring for multiple Postdoctoral Fellow positions at NYU. We use large scale human genome engineering to develop off-the-shelf cell therapies using iPSCs.   The lab uses Synthetic Biology to build allogeneic Dendritic Cells from iPSCs as a platform for cell immunotherapies. We are interested in all…

Continue Reading Postdoc – Human Genome Engineering, Cell Therapies, iPSCs, Synthetic Biology

Researchers identify sustainable source of im

image: Monkey iPSCs with edited CCR5 locus growing in culture. view more  Credit: Image Credit: Saritha D’Souza, Wisconsin National Primate Research Center, USA Genetic engineering can make immune cells resistant to infection with human or monkey (simian) immunodeficiency virus (HIV and SIV, respectively). Recently, treatment with HIV-resistant immune cells has given…

Continue Reading Researchers identify sustainable source of im

Modeling the Human Brain with Organoids

iPSCs As Models, Part 2: Modeling the Human Brain with Organoids The store will not work correctly in the case when cookies are disabled. JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript…

Continue Reading Modeling the Human Brain with Organoids

One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors

Introduction of CRX and NEUROD1 using piggyBac vector into iPSCs and differentiation to induced photoreceptor-like cells (iPRCs) (A) Design of polycistronic piggyBac vector for CRX and NEUROD1 mediated conversion under control of the tetracycline operator rtTA and neomycin resistance gene. Dox: doxycycline, rtTA: reverse tetracycline transactivator, neo: neomycin resistance gene….

Continue Reading One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors

Regenerative therapies with induced pluripotent stem cells

Induced pluripotent stem cells (iPSCs) are a type of stem cell with pluripotent characteristics. That is, they have the capacity to generate most of the tissues and cells of all adult cell types. They are obtained artificially from a cell that was initially not pluripotent. Due…

Continue Reading Regenerative therapies with induced pluripotent stem cells

Cutting Edge Agriculture Gene Editing with Cas-CLOVER

Blog Agriculture Biotechnology Though CRISPR-Cas enabled targeted genome engineering across a vast array of organisms, the system features major disadvantages. Frequent off-target mutagenesis, licensing restrictions and non-ideal economic license terms have inhibited commercial crop-science product upscaling, and, in many cases, entirely disqualified CRISPR’s use by many commercial crop developers. Seeking…

Continue Reading Cutting Edge Agriculture Gene Editing with Cas-CLOVER

A hydrogel-based 3D culture model for Down syndrome-myeloid leukemia and ex vivo drug testing

Abstract Induced pluripotent stem cells (iPSCs) provide an extraordinary tool for disease modeling owing to their potential to differentiate into the desired cell type. The differentiation of iPSCs is typically performed on 2-dimensional monolayers of stromal cell or animal tissue derived extracellular matrices. Recent advancements in disease modeling have utilized…

Continue Reading A hydrogel-based 3D culture model for Down syndrome-myeloid leukemia and ex vivo drug testing

Endothelial Cell Differentiation from iPSCs – iPSC Differentiation Service – Stem Cell Services – Service – Research

iPSC-Derived Endothelial Cells Optimized iPSC Generation & Differentiation Protocols High Purity & Well Characterized iPSC-derived endothelial cells (EC) are valuable tools that can help researchers better understand vascular diseases. At ASC, we use a fast, cost-effective differentiation procedure that allows our team to deliver high-quality cells in…

Continue Reading Endothelial Cell Differentiation from iPSCs – iPSC Differentiation Service – Stem Cell Services – Service – Research

Precision Control of Culture Conditions for Induced Pluripotent Stem Cells

By Sally Temple The Nobel Prize–winning discovery that mature, specialized cells can be reprogrammed to lend them pluripotency (that is, the ability to develop into all tissues of the body) unleashed vast potential in the fields of disease modeling, drug screening, regenerative medicine, and wound healing. The reprogrammed cells are…

Continue Reading Precision Control of Culture Conditions for Induced Pluripotent Stem Cells

Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells

doi.org/10.1016/j.ymgmr.2022.100852Get rights and content Highlights • We generated induced pluripotent stem cells (iPSCs) from two late-infantile MLD patient-derived skin fibroblasts. • We differentiated MLD phenotype specific motor neurons (MNs) under the culture condition. • We described the pathological observation of MLD patients derived motor neuron progenitors (MNPs). • We described…

Continue Reading Generation and characterization of motor neuron progenitors and motor neurons using metachromatic leukodystrophy-induced pluripotent stem cells

Science Papers on Spatial Characterization of Sensory Neurons, Megakaryocyte Differentiation Mapping

A spatial transcriptomic analysis of key human sensory neurons is presented in Science Translational Medicine this week, uncovering potential new drug targets for pain management. Despite the significant medical problem pain represents, there has been little progress translating preclinical work on peripheral pain mechanisms, which has largely been done in rodents,…

Continue Reading Science Papers on Spatial Characterization of Sensory Neurons, Megakaryocyte Differentiation Mapping

CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy

Ishino Y, Shinagawa H, Makino K, et al. Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product. J Bacteriol. 1987;169:5429–33. CAS  PubMed  PubMed Central  Google Scholar  Jansen R, van Embden JDA, Gaastra W, et al. Identification of genes…

Continue Reading CRISPR-Cas9 Gene Therapy for Duchenne Muscular Dystrophy

Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection

INTRODUCTION Dengue is the most common mosquito-borne viral disease globally (1). This acute disease, which can be life-threatening, is caused by four different dengue viruses (DENVs) (DENV-1, DENV-2, DENV-3, and DENV-4). An estimated 390 million people are infected with these DENVs annually (2), and populations throughout the tropics face frequent…

Continue Reading Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection

Generation of NKX2.5 GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts

doi: 10.3389/fcell.2021.797927. eCollection 2021. Leyre López-Muneta  1 , Javier Linares  1 , Oscar Casis  2 , Laura Martínez-Ibáñez  3 , Arantxa González Miqueo  3   4 , Jaione Bezunartea  5 , Ana Maria Sanchez de la Nava  6   7 , Mónica Gallego  2 , María Eugenia Fernández-Santos  6   7 , Juan Roberto Rodriguez-Madoz  8 , Xabier L Aranguren …

Continue Reading Generation of NKX2.5 GFP Reporter Human iPSCs and Differentiation Into Functional Cardiac Fibroblasts

Creative Bioarray Built Professional Cell Reprogramming Services with Cutting-edge Technologies to Accelerate Drug Development and Research

Creative Bioarray announced the release of its professional cell reprogramming services with cutting-edge technologies to accelerate drug development and research. New York, USA – January 24, 2022 – Cell culture platform, the division of Creative Bioarray, focuses on developing complete cell culture solutions with plenty of choices for the next…

Continue Reading Creative Bioarray Built Professional Cell Reprogramming Services with Cutting-edge Technologies to Accelerate Drug Development and Research

PostDoc iPSCs for toxicology (m/w/d) – Biberach

OUR COMPANY At Boehringer Ingelheim we develop breakthrough therapies and innovative healthcare solutions in areas of unmet medical need for both humans and animals. As a family owned company, we focus on long-term performance. We believe that, if we have talented and ambitious people who are passionate about innovation, there…

Continue Reading PostDoc iPSCs for toxicology (m/w/d) – Biberach

Pluristyx, panCELLa, and Implant Therapeutics Announce a Strategic Alliance to Manufacture and Distribute Genetically Modified, Clinical-grade Human-induced Pluripotent Stem Cells

SEATTLE–(BUSINESS WIRE)–Pluristyx, Inc., an advanced therapy tools and services biotechnology company, panCELLa, a privately held biotechnology company, and Implant Therapeutics, a developer of genetically engineered stem cells, today announced they have entered into a manufacturing and distribution strategic alliance that offers cell therapy companies streamlined access to the next generation…

Continue Reading Pluristyx, panCELLa, and Implant Therapeutics Announce a Strategic Alliance to Manufacture and Distribute Genetically Modified, Clinical-grade Human-induced Pluripotent Stem Cells

Applications of iPSCs in Gaucher Disease and other rare sphingolipidoses

Chapter contents Book contents Volume 16 in Advances in Stem Cell Biology 2022, Pages 197-224 doi.org/10.1016/B978-0-323-85767-3.00001-3Get rights and content Abstract In this chapter, an overview of various applications of induced pluripotent cells (iPSCs) is given. This chapter focuses on the uses of iPSCs in inherited diseases and, particularly, in the…

Continue Reading Applications of iPSCs in Gaucher Disease and other rare sphingolipidoses

Generation of a human iPSC line CIPi001-A from a benign familial infantile epilepsy patient related 16p11.2 deletion

doi.org/10.1016/j.scr.2021.102634Get rights and content Abstract The features of 16p11.2 deletion phenotype is developmental delay, intellectual disability, and autism spectrum disorder. Seizures are observed in approximately 20% of individuals with the microdeletion. Induced pluripotent stem cells (iPSCs) were generated from erythroblasts obtained from a child diagnosed with benign familial infantile epilepsy,…

Continue Reading Generation of a human iPSC line CIPi001-A from a benign familial infantile epilepsy patient related 16p11.2 deletion

NIH researchers develop first stem cell model of albinism to study related eye conditions

News Release Tuesday, January 11, 2022 Use of patient-derived stem cells will enable high-throughput drug screening for potential therapeutics. Researchers at the National Eye Institute (NEI) have developed the first patient-derived stem cell model for studying eye conditions related to oculocutaneous albinism (OCA). The model’s development is described in…

Continue Reading NIH researchers develop first stem cell model of albinism to study related eye conditions

Applications of human iPSCs for disease modeling and screening

The development of physiologically relevant human models for neurological diseases remains a challenge for pre-clinical drug discovery. With the emergence of human induced pluripotent stem cell (hiPSC) technology, it is now possible to design and manufacture cell types that are critical players in neural disease pathogenesis, such as neurons, astrocytes…

Continue Reading Applications of human iPSCs for disease modeling and screening

Rare Diseases Are Focus of Latest Yale Journal of Biology and Medicine

The Yale Journal of Biology and Medicine’s (YJBM’s) December 2021 issue on rare disease has been published on PubMed Central. This focus issue features articles on just a few of the estimated 7,000 rare diseases people in the world experience. As we get closer to Rare Disease Day on February…

Continue Reading Rare Diseases Are Focus of Latest Yale Journal of Biology and Medicine

Citius Pharmaceuticals, Inc. to Present at Upcoming Virtual Conferences

H.C. Wainwright BioConnect 2022 Conference January 10-13, 2022 Biotech Showcase Virtual Conference January 17-19, 2022 CRANFORD, N.J., Jan. 4, 2022 /PRNewswire/ — Citius Pharmaceuticals, Inc. (“Citius” or the “Company”) (Nasdaq: CTXR), a late-stage biopharmaceutical company dedicated to the development and commercialization of first-in-class critical care products with a focus on…

Continue Reading Citius Pharmaceuticals, Inc. to Present at Upcoming Virtual Conferences

Investigating changes in the proteostasis capabilities of iPSC-neurons during development and in FTD using iPSC-neurons with MAPT mutations

This article was originally published here Alzheimers Dement. 2021 Dec;17 Suppl 2:e058308. doi: 10.1002/alz.058308. ABSTRACT BACKGROUND: Mutations in microtubule-associated protein tau (MAPT) gene are causative of Frontotemporal Dementia (FTD). Many of the features associated with the development of tau pathology, e.g high levels of tau phosphorylation, are also present in…

Continue Reading Investigating changes in the proteostasis capabilities of iPSC-neurons during development and in FTD using iPSC-neurons with MAPT mutations

Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients

Figure 6 Dynamics of pluripotent and germ cells markers during hPGCLCs -TS induction. ( A… Figure 6 Dynamics of pluripotent and germ cells markers during hPGCLCs -TS induction. (A) Schematic protocol used to generate hPGCLCs. (B) hiPSCs-TS (p20), hEpiLC-TS (D.2), and hPGCLCs-TS (D.6) quantification of the relative expression of OCT4,…

Continue Reading Generation of Primordial Germ Cell-like Cells from iPSCs Derived from Turner Syndrome Patients

iPSCs and DRGs: stepping stones to new pain therapies

doi.org/10.1016/j.molmed.2021.11.005Get rights and content Highlights Voltage-gated sodium (NaV) channels are key drivers of pain in humans and contribute to neuronal excitability and have been regarded as opportune therapeutic targets. The limited success of developing pain therapies targeting NaV channels may reflect the limitations of preclinical screening systems, as heterologous cell…

Continue Reading iPSCs and DRGs: stepping stones to new pain therapies

Rapid generation of ventral spinal cord-like astrocytes from human iPSCs for modeling non-cell autonomous mechanisms of lower motor neuron disease

Abstract Background: Astrocytes play important roles in the function and survival of neuronal cells. Dysfunctions of astrocytes are associated with numerous disorders and diseases of the nervous system, including motor neuron diseases such as amyotrophic lateral sclerosis (ALS). Human induced pluripotent stem cell (iPSC)-based approaches are becoming increasingly important for…

Continue Reading Rapid generation of ventral spinal cord-like astrocytes from human iPSCs for modeling non-cell autonomous mechanisms of lower motor neuron disease

Fate Therapeutics Highlights Positive Durability of

6 of 10 Patients Naïve to Treatment with Autologous CAR T-cell Therapy Continue in Ongoing Response at Median Follow-up of 9.1 Months, including 4 Patients with >6 Months Follow-up, at ≥90 Million FT516 Cells per Dose 3 of 8 Patients Previously Treated with Autologous CAR T-cell Therapy Achieve Complete Response…

Continue Reading Fate Therapeutics Highlights Positive Durability of

Induced Pluripotent Stem Cells Detection via Ensemble Yolo Network

Induced pluripotent stem cells (iPSCs) have huge potential in regenerative medicine research and industrial applications. However, building automatic method without using cell staining technique for iPSCs identification is an important challenge. To improve the efficiency of producing iPSCs, we build an accurate and noninvasive iPSCs colonies detection method via ensemble…

Continue Reading Induced Pluripotent Stem Cells Detection via Ensemble Yolo Network

Stomach organoid created from multiple stem cell types | 2021-12-10

A group of scientists at the Cincinnati Children’s Hospital has used separate lines of human induced pluripotent stem cells (iPSCs) to create stomach organoids with a three-layered structure and gastric function such as smooth muscle contraction and glandular secretion. The team reported its results in the December 2021, issue of…

Continue Reading Stomach organoid created from multiple stem cell types | 2021-12-10

An Optimized Culture Medium for Induced Pluripotent Stem Cells

In 2006, Kazutoshi Takahashi and Shinya Yamanaka made a revolutionary breakthrough when they reprogrammed terminally differentiated, lineage-restricted adult somatic cells into a pluripotent state via the expression of transcription factors Oct4, Sox2, Klf4, and c-Myc.1 Now, researchers can differentiate reprogrammed induced pluripotent stem cells (iPSCs) into any cell type and…

Continue Reading An Optimized Culture Medium for Induced Pluripotent Stem Cells

Doctoral student finds alternative cell option for organs-on-chips — ScienceDaily

Organ-on-a-chip technology has provided a push to discover new drugs for a variety of rare and ignored diseases for which current models either don’t exist or lack precision. In particular, these platforms can include the cells of a patient, thus resulting in patient-specific discovery. As an example, even though sickle…

Continue Reading Doctoral student finds alternative cell option for organs-on-chips — ScienceDaily

Researchers Make New iPSC Models of Friedreich’s Ataxia

A team of scientists at Koc University in Turkey has created three new cell models of Friedreich’s ataxia (FA) derived from patients with repeat expansions in their FXN gene. The models “will facilitate studies to understand molecular mechanisms related to FRDA [Friedreich’s ataxia] pathology [disease processes] as well as therapeutic investigations…

Continue Reading Researchers Make New iPSC Models of Friedreich’s Ataxia

MD Anderson research highlights 9 December

ATLANTA ― The University of Texas MD Anderson Cancer Center‘s Research Highlights provides a glimpse into basic, translational and clinical cancer research from MD Anderson experts. This special edition features presentations at the 2021 American Society of Hematology (ASH) Annual Meeting on innovative targeted therapies, new combination approaches, and novel…

Continue Reading MD Anderson research highlights 9 December

Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant

Abstract With the wide adoption of genomic sequencing in children having seizures, an increasing number of SCN2A genetic variants have been revealed as genetic causes of epilepsy. Voltage-gated sodium channel Nav1.2, encoded by gene SCN2A, is predominantly expressed in the pyramidal excitatory neurons and supports action potential (AP) firing. One…

Continue Reading Hyperexcitability and Pharmacological Responsiveness of Cortical Neurons Derived from Human iPSCs Carrying Epilepsy-Associated Sodium Channel Nav1.2-L1342P Genetic Variant

How Artificial Intelligence Can Be Used To Augment Stem Cell Therapy In Hospitals

Stem cell therapy comes with its own set of challenges despite being a revolutionary discovery in modern healthcare. As we know, AI has several applications in the deep and diverse field of healthcare. So, stem cell AI’s incredible capabilities can overcome those challenges and truly improve stem cell therapy in…

Continue Reading How Artificial Intelligence Can Be Used To Augment Stem Cell Therapy In Hospitals

Scientific webinars on SelectScience

Genome engineering has revolutionized medical research through the ability to precisely edit the DNA sequence of cells. In combination with human induced pluripotent stem cells (hiPSCs), editing the genome can provide unprecedented insight into disease-causing mechanisms on a patient and tissue-specific basis. A major challenge, however, is the efficient generation…

Continue Reading Scientific webinars on SelectScience

CRISPR-Engineered Cells Release Drug in Response to Inflammation When Implanted into Mice

Source: Science Photo Library/Getty Images Researchers at Washington University School of Medicine in St. Louis have used CRISPR-Cas9 genome editing to engineer induced pluripotent stem cells (iPSCs) that can be implanted subcutaneously to deliver an anticytokine biologic drug in response to inflammation caused by rheumatoid arthritis. When implanted into a…

Continue Reading CRISPR-Engineered Cells Release Drug in Response to Inflammation When Implanted into Mice

New Techniques and Complex Models

CRISPR systems that rely on inactivated Cas enzymes—that is, dead Cas (dCas) enzymes—never looked more alive. They harness the targeting power associated with CRISPR—but not the double-strand cuts. As such, they give researchers new ways to interrogate and manipulate gene function. Possibilities include CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa)…

Continue Reading New Techniques and Complex Models

Editas Medicine Presents Data on New SLEEK Gene Editing

SLEEK enables high efficiency, multi-transgene knock-in of induced Pluripotent Stem Cells (iPSCs), T cells, and Natural Killer (NK) cells Data support SLEEK as an optimized approach to develop next generation cell therapy medicines CAMBRIDGE, Mass., Aug. 20, 2021 (GLOBE NEWSWIRE) — Editas Medicine, Inc. (Nasdaq: EDIT), a leading genome editing company, today…

Continue Reading Editas Medicine Presents Data on New SLEEK Gene Editing

Python fast way to get ONLY MAIN metadata for GSE ? (not walking through thousands underlying GSM-samples : slow or even endless)

  Not Python but using EntrezDirect you can get: $ esearch -db bioproject -query “GSE118723” | esummary | xtract -pattern DocumentSummary -element Project_Description Quantification of gene expression levels at the single cell level has revealed that gene expression can vary substantially even across a population of homogeneous cells. However, it…

Continue Reading Python fast way to get ONLY MAIN metadata for GSE ? (not walking through thousands underlying GSM-samples : slow or even endless)