Tag: ischemia-reperfusion

CircRNA and Stroke: New Insight of Potential Biomarkers and Therapeutic Targets

Diener HC, Hankey GJ (2020) Primary and secondary Prevention of ischemic Stroke and Cerebral Hemorrhage: JACC Focus Seminar. J Am Coll Cardiol 75(15):1804–1818 Article  PubMed  Google Scholar  Dou Z, Yu Q, Wang G, Wu S, Reis C, Ruan W, Yan F, Chen G (2020) Circular RNA expression profiles alter significantly…

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Key Genes for Pyroptosis-induced Salivary Gland Inflammation

Kaiyuan Zhang,1,* Ziyue Luo,1,* Xinchao Zhu,1 Xinyi Yao,1 Dingqi Lu,2 Liying Chen,1 Tao Hong,1 Yating Ren,1 Xinchang Wang3 1Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China; 2First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China;…

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Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research

Summary This study established a protocol focusing on the technical refinement of a mouse model of bilateral renal ischemia-reperfusion for acute kidney injury research. Transcript Acute kidney injury is a major risk factor associated with high mortality in patients with cardiac arrest after return of circulation. This procedure can be…

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cGAS-STING signaling pathway promotes hypoxia-induced renal fibrosis by regulating PFKFB3-mediated glycolysis

Hypoxia has long been considered to play an active role in the progression of fibrosis in chronic kidney disease, but its specific mechanism is not fully understood. The stimulator of interferon genes (STING) has been a research hotspot in the fields of tumor, immunity, and infection in recent years, and…

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Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort

Chronic Kidney Disease in the United States, 2021. www.cdc.gov/kidneydisease/publications-resources/ckd-national-facts.html. Saran, R. et al. US renal data system 2019 annual data report: Epidemiology of kidney disease in the United States. Am. J. Kidney Dis. 75, A6–A7 (2020). Article  PubMed  Google Scholar  Matsushita, K. et al. Epidemiology and risk of cardiovascular disease…

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2-BFI Protects Against Cerebral Ischemia-Reperfusion Injury by Inhibiting the cGAS-STING Pathway by Lu Xu, Meiqi Zhao, Ye Xu, Chunfei Xu, Lili Ma, Tong Xu, Yungang Cao, Zhao Han :: SSRN

28 Pages Posted: 17 Oct 2023 See all articles by Lu Xu Wenzhou Medical University – Department of Neurology Wenzhou Medical University – Department of Neurology Wenzhou Medical University – Department of Neurology Wenzhou Medical University – Department of Neurology Wenzhou…

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Figure 5 | lncRNA DLX6-AS1 Promotes Myocardial Ischemia-Reperfusion Injury through Mediating the miR-204-5p/FBXW7 Axis

Mediators of Inflammation/ 2023/ Article/ Fig 5 / Research Article Figure 5 DLX6-AS1 promoted FBXW7 expression by sponging miR-204-5p. (a) The predicted binding sites between miR-204-5p and FBXW7 were presented. (b) The interaction between miR-204-5p and FBXW7 in H9c2 cells was verified by luciferase reporter assay. (c) H9c2 cells were…

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The activation of cGAS-STING in acute kidney injury

Introduction AKI, which is characterised by necroinflammation due to damage and necrosis of the kidney’s intrinsic cells,1 is a common clinical syndrome, occurring in 10–15% of hospitalized patients, whereas in the ICU this percentage is as high as 50%.2 The development of AKI is involved in the production of reactive…

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GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion

doi: 10.1038/s41420-023-01663-z. Affiliations Expand Affiliations 1 Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Nanning, China. 2 Guangxi Clinical Research Center for Anesthesiology, Nanning, China. 3 Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine, Nanning, China. 4 Guangxi Health Commission Key Laboratory of Basic Science and…

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Ulcerative Colitis Treatment by CLP loaded with NLRP3 siRNA

Introduction Since the 20th century, tThe incidence of ulcerative colitis (UC) has been increasing over time, negatively affecting peoples’ health.1,2 UC is a multifactorial induced inflammatory bowel disease (IBD) characterized by chronic recurrent and remitting mucosal inflammation.3,4 It originates in the rectum and then extends to the proximal segments of…

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Identification of autophagy-associated circRNAs in sepsis-induced cardiomyopathy of mice

Singer, M. et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA 315, 801–810. doi.org/10.1001/jama.2016.0287 (2016). Article  CAS  PubMed  PubMed Central  Google Scholar  Fleischmann, C. et al. Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations. Am J Respir Crit Care Med…

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Mendelian randomization uncovers a protective effect of interleukin-1 receptor antagonist on kidney function

Ramesh, G. & Reeves, W. B. Inflammatory cytokines in acute renal failure. Kidney Int. Suppl. S56–S61. doi.org/10.1111/j.1523-1755.2004.09109.x (2004) Ye, S., Ozgur, B. & Campese, V. M. Renal afferent impulses, the posterior hypothalamus, and hypertension in rats with chronic renal failure. Kidney Int. 51, 722–727 (1997). Article  CAS  PubMed  Google Scholar …

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Revive Therapeutics Announces Results of Phase 3 Clinical Study for Bucillamine in the Treatment of COVID-19

TORONTO, July 06, 2023 (GLOBE NEWSWIRE) — Revive Therapeutics Ltd. (“Revive” or the “Company”) (OTCQB: RVVTF) (CSE: RVV) (FRANKFURT:31R), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, today announced results of the Company’s Phase 3 clinical trial (the “Study”)…

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Revive Therapeutics Announces Results of Phase 3 Clinical

TORONTO, July 06, 2023 (GLOBE NEWSWIRE) — Revive Therapeutics Ltd. (“Revive” or the “Company”) (OTCQB: RVVTF) (CSE: RVV) (FRANKFURT:31R), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, today announced results of the Company’s Phase 3 clinical trial (the “Study”)…

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TXNIP: A key protein in the cellular stress response pathway and a potential therapeutic target

Junn, E. et al. Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J. Immunol. 164, 6287–6295 (2000). Article  CAS  PubMed  Google Scholar  Nishiyama, A. et al. Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression. J. Biol….

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Transcriptomic and in vivo approaches introduced human iPSC-derived microvesicles for skin rejuvenation

Boer, M., Duchnik, E., Maleszka, R. & Marchlewicz, M. Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function. Postepy Dermatol. Alergol. 33, 1–5 (2016). PubMed  PubMed Central  Google Scholar  Watt, F. M. & Fujiwara, H. Cell-extracellular matrix interactions in normal and diseased skin. Cold Spring Harb….

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Integrated analysis of circRNA-associated ceRNA in ischemic stroke

1 Introduction Stroke is the leading cause of permanent disability (Diener and Hankey, 2020). The latest global burden of disease (GBD) study (GBD 2019 Diseases and Injuries Collaborators, 2020) indicated that stroke is the leading cause of death in the Chinese population. The overall lifetime risk of stroke in China…

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Revive Therapeutics Ltd is staying the course on its Phase 3 trial of Bucillamine in Covid-19 patients after meeting with the FDA

Revive Therapeutics Ltd (CSE:RVV, OTCQB:RVVTF) has issued an update on the Phase 3 trial of its drug Bucillamine in patients with mild to moderate COVID-19. Back in March, the company met with the US Food and Drug Administration (FDA) to get approval for the proposed endpoints of the study of…

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Hallmarks of cardiovascular ageing | Nature Reviews Cardiology

Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98–102 (2009). Article  CAS  PubMed  PubMed Central  Google Scholar  Senyo, S. E. et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493, 433–436 (2013). Article  CAS  PubMed  Google Scholar  Bergmann, O. et al. Dynamics of cell generation and…

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2023-05-12 | CSE:RVV | Press Release

TORONTO, May 12, 2023 (GLOBE NEWSWIRE) — Revive Therapeutics Ltd. (“Revive” or the “Company”) (OTCQB: RVVTF) (CSE: RVV) (FRANKFURT:31R), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, announced today an update on the Company’s U.S. Food & Drug Administration…

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Revive Therapeutics Provides Update of Phase 3 Clinical

TORONTO, March 20, 2023 (GLOBE NEWSWIRE) — Revive Therapeutics Ltd. (“Revive” or the “Company”) (OTCQB: RVVTF) (CSE: RVV) (FRANKFURT:31R), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, announced today an update on the Company’s U.S. Food & Drug Administration…

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Revive Therapeutics Provides Update of Phase 3 Clinical Study for Bucillamine in the Treatment of COVID-19

Revive Therapeutics Ltd. TORONTO, March 20, 2023 (GLOBE NEWSWIRE) — Revive Therapeutics Ltd. (“Revive” or the “Company”) (OTCQB: RVVTF) (CSE: RVV) (FRANKFURT:31R), a specialty life sciences company focused on the research and development of therapeutics for medical needs and rare disorders, announced today an update on the Company’s U.S. Food…

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NAD+ precursor supplementation prevents mtRNA/RIG-I-dependent inflammation during kidney injury

Altered NAD+ metabolism is prominent in diseased human kidneys We collected human kidney samples from healthy controls (n = 25) and patients with diabetic or hypertensive KD, defined as estimated glomerular filtration rate (eGFR) less than 60 ml min−1 per 1.73 m2 and kidney fibrosis (n = 25) (Fig. 1a). The mean eGFR values were 95 ml min−1 per 1.73 m2 (healthy…

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Small Extracellular Vesicles Derived from Induced Pluripotent Stem Cells in the Treatment of Myocardial Injury

Induced pluripotent stem cell (iPSC) therapy brings great hope to the treatment of myocardial injuries, while extracellular vesicles may be one of the main mechanisms of its action. iPSC-derived small extracellular vesicles (iPSCs-sEVs) can carry genetic and proteinaceous substances and mediate the interaction between iPSCs and target cells. In recent…

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Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis | Journal of Neuroinflammation

Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–8. doi.org/10.1097/00001199-200609000-00001. Article  PubMed  Google Scholar  Cao HQ, Dong ED. An update on spinal cord injury research. Neurosci Bull. 2013;29:94–102. doi.org/10.1007/s12264-012-1277-8. Article  PubMed  Google Scholar  O’Donnell MJ, Xavier D,…

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Acute phase of ischemia-reperfusion in rats

Introduction Stroke is one of the leading causes of death and disability worldwide, which causes substantial economic and social burdens.1 Ischemic stroke is caused by insufficient blood and oxygen supply to the brain,2 accounting for about 85% of the casualties of stroke patients.3 The concept of treatment for ischemic injury…

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Generation of Hook Ischemia-Reperfusion Model using a Three-Day Developing Chick Embryo

This paper describes ischemia-reperfusion (I/R) modeling in a 3-day chick embryo using a spinal needle customized hook to better understand I/R development and treatment. This model is simple, quick, and inexpensive. Hi, I am Dr.Syed Shadab Raza, the principal investigator for the Laboratory for Stem Cells and Restorative Neurology, located…

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miRNAs and mRNAs in intestinal ischemia-reperfusion injury

Introduction Intestinal ischemia-reperfusion (II/R) injury is a severe clinical complication common in the Intensive Care Unit (ICU). It is associated with high morbidity and mortality.1 Usually, this problem is followed by various causes, including sepsis, shock, trauma, and so on.2 Intestinal ischemia-reperfusion injury destroys intestinal tissue and impairs the function…

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