Tag: ISD

The Woodlands-based forensic lab is solving the cold case of a 35-year-old from Georgia

A Woodlands forensic lab has identified a woman who was found wrapped in plastic in a trash can in a cold case in Georgia 35 years ago. The Georgia Bureau of Investigation hired Woodlands-based Othram to identify Chong Un Kim, a South Korean woman who was 26 when she was…

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Woodlands-based forensics lab cracks 35-year-old Georgia cold case

A Woodlands forensics lab has identified a woman found wrapped in plastic inside a trash bin in a Georgia cold case 35 years ago. The Georgia Bureau of Investigation hired The Woodlands-based Othram to identify Chong Un Kim, a South Korean woman who was 26 when she was found. As the…

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CDC Committee Votes Unanimously to Recommend Nirsevimab for Preventing RSV in Infants

The CDC’s ACIP voted today to recommend nirsevimab-alip (Beyfortus) for the protection against severe respiratory syncytial virus (RSV) in the first respiratory virus season for all infants and for a second season for those who remain at increased risk for severe RSV. Specifically, the ACIP committee voted on the following…

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wwPDB News – NMR restraint remediation conforms to standard NMR-STAR and NEF format

NMR data files are standardized in NEF and NMR-STAR format [Ulrich, 2019] for the PDB entries which have NMR data in many different software specific formats. This remediation project provides unified NMR data in single NMR-STAR/NEF file for the PDB entries. wwPDB is moving forward single file upload for NMR data (restraints,…

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Meloxicam inhibits STING phosphorylation and alleviates intracellular DNA-mediated autoimmune responses

Mice Trex1+/– mice (C57BL/6) were gifts from D. Barnes and T. Lindahl (Cancer Research UK). All animal experiments were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and with the approval of the Institutional Animal Care and Use Committee (IACUC-DWZX-2020-511)….

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Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex

SARS-CoV-2 infection induces mtDNA release and recognition by cGAS Recent studies revealed that SARS-CoV-2 stimulation could cause the accumulation of intracellular and intercellular DNA due to cell fusion, cell death and even tissue damage.17,19,27 To detect SARS-CoV-2-triggered release of DNA during infection, we first detected the cytosolic dsDNA pattern by…

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Zai Lab to Present Two New Phase 3 Analyses for Niraparib

SHANGHAI, China and CAMBRIDGE, Mass., Feb. 22, 2023 (GLOBE NEWSWIRE) — Zai Lab Limited (NASDAQ: ZLAB; HKEX: 9688) will present two oral presentations highlighting the ad hoc interim overall survival (OS) study results of ZEJULA® (niraparib) from the NORA Phase 3 study and a post hoc analysis from the Phase…

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Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity

Significance Interferon (IFN)-mediated antiviral responses serve as the first line of the host innate immune defense against viral infection. Here we identify a previously uncharacterized protein designated phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein (PINLYP), which is essential for embryonic development and plays an important role in type I IFN…

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mitochondrial dna damage triggers an ifn mediated immune response

2.6 Mitochondrial Damage-Induced Mitochondrial DNA Release is Central to Chronic Kidney Disease-Induced Type-I-Interferon Response in Vascular Smooth Muscle Cells DNA released from nuclear or mitochondria is the main source of endogenous DNA that activates cGAS-STING pathway. This is thought to be mediated by the presence 75 of leaked mitochondrial DNA…

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