Tag: iseq

Metagenomic Sequencing Market worth $4.5 billion in 2028

PRESS RELEASE Published December 5, 2023 “The European market is the second-largest metagenomic sequencing market globally, mainly due to factors such as increasing number of research projects, especially in the field of soil microbiome metagenomics, in the region.” Browse 226 market data Tables and 44 Figures spread through 266 Pages…

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Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations

Ethical statement Our research complies with all relevant ethical regulations, including the Declaration of Helsinki and has been approved by the Institutional Review Boards of University of Chicago, Duke University and the Alliance to Cure Cavernous Malformations. Cerebral cavernous malformation lesions All human CCM tissue specimens have been previously reported18,19…

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Illumina: The Measurement Monopoly – by Elliot Hershberg

Welcome to The Century of Biology! This newsletter explores data, companies, and ideas from the frontier of biology. You can subscribe for free to have the next post delivered to your inbox: Enjoy! 🧬 No technology has ever improved more rapidly than DNA sequencing. The resulting explosion of genomic data…

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Does single end sequencing sequence both strands of the original fragment?

Does single end sequencing sequence both strands of the original fragment? 1 Our lab has again questioned if single end sequencing does indeed sequence both strands of the original fragment, the Illumina videos do make this somewhat confusing. Can we confirm that the below diagram is indeed what happens? In…

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Global Metagenomic Sequencing Market Report 2023

DUBLIN, Aug. 11, 2023 /PRNewswire/ — The “Global Metagenomic Sequencing Market by Product & Services (Reagent, Consumables, Instrument), Workflow (Sample Preparation, Sequencing), Technology (16S rRNA, Shotgun, Whole-genome), Application (Drug Discovery, Diagnostic, Industrial), and Region – Forecast to 2028” report has been added to  ResearchAndMarkets.com’s offering. The global metagenomic sequencing market is…

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16S rRNA gene primer choice impacts off-target amplification in human gastrointestinal tract biopsies and microbiome profiling

The problem of off-target amplification The widely used standardized protocol for 16S rRNA gene amplicon sequencing7,14 turned out to be inadequate due to robust off-target amplification of human DNA during the analysis of bacteriome in samples of different biopsy sites from the upper gastrointestinal (GI) tract. In samples from all…

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Metagenomic Sequencing Market Is Likely to Experience a Massive Growth in Near Future | Taiwan News

The latest report published by Report Ocean, titled “ Metagenomic Sequencing: Global Industry Trends, Share, Size, Growth, Opportunity, and Forecast 2023 to 2031,” offers a comprehensive assessment of the industry, including valuable insights into market trends. The report encompasses competitor and regional analysis, as well as the latest developments in the market….

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Next Generation Sequencing Market is projected to grow at a

Visiongain has published a new report entitled Next Generation Sequencing Market Report 2023-2033: Forecasts by Type (Consumables, Bioinformatics, Sequencing Services, Pre-sequencing Services, Instruments), by Workflow (Library Preparation, Sequencing, Data Analysis), by Application (Oncology, Reproductive Health, Genetic and Rare Diseases, Consumer Genomics, Agrigenomics & Forensics, Others), by End-use (Hospitals and Clinics,…

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Metagenomic Sequencing Market worth $4.5 Billion

CHICAGO, July 25, 2023 /PRNewswire/ — In the near future, the metagenomic sequencing industry is poised to undergo a transformative revolution, becoming a pivotal driving force in diverse fields such as healthcare, agriculture, environmental science, and beyond. Advancements in sequencing technologies, data analytics, and computational capabilities will propel metagenomic studies to…

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Next Generation Sequencing Kits Market

ReportLinker Segmented by Workflow (Library Preparation, Cluster Generation, Sequencing Reagents Kits), By Sequencing Type (WES and WGS, Targeted Sequencing, Long Read Sequencing, Other Sequencing), By Usage Area (Clinical, Research), By Application (Oncology, Rare Diseases, Genetic Disorders, Reproductive Health, Others), By End User (Academic and Research Institutions, Pharmaceutical and Biotechnology Companies,…

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In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir

Ethics All animal experiments were conducted in accordance with the University of Tokyo’s Regulations for Animal Care and Use, which were approved by the Animal Experiment Committee of the Institute of Medical Science, the University of Tokyo. The committee acknowledged and accepted both the legal and ethical responsibility for the…

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Capability of the iSeq 100 sequencing system from Illumina to detect low-level substitutions in the human mitochondrial genome

Introduction Massively parallel sequencing (MPS) technologies allow for a more accurate and precise determination of the heteroplasmy level (i.e., the coexistence of different nucleotide variants in the same mtDNA position) in mitochondrial genomes compared with the traditional dideoxy method. Even mtDNA minority variants that are below the dideoxy sequencing detection…

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HTSlib threads when ingesting large bgzipped FASTA

HTSlib threads when ingesting large bgzipped FASTA 0 Is it possible to use HTSlib thread pool when loading large (genomic) FASTA sequences? Here’s a sample code: #include <htslib/hts.h> #include <htslib/sam.h> #include <htslib/faidx.h> #include <htslib/bgzf.h> #include <htslib/thread_pool.h> char fn[] = “/path/to/bgzipped.fasta.fa.gz”; int nthreads = 4; faidx_t *faidx = fai_load(fn); hts_tpool *tpool…

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A Guide to NGS Sequencers

Next-generation sequencing (NGS) is a comprehensive method that helps evaluate DNA or RNA sequences to analyze genetic variations useful for disease diagnosis and other biological phenomena. Image Credit: Elpisterra/Shutterstock.com   In the last two decades, NGS sequencers have significantly improved the speed, throughput, and accuracy of NGS and have revolutionized…

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Four MORE Chinese DNA Sequencing Startups

Yesterday I wrote about eight Chinese DNA sequencing companies. Today I found out about 4 more! So let’s very quickly review! Looks like Illumina-style SBS using an unspecified surface amplification approach. According to their website: Q30>85%, run outputs up to 300Gb. Two instruments, the Salus Pro and Salus Evo. Seems…

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Illumina Sequencing Instruments Affected by Maximum Severity Vulnerability

Posted By HIPAA Journal on May 5, 2023 Healthcare providers and laboratory personnel have been warned about a maximum severity vulnerability in Illumina Universal Copy Service software used by its DNA sequencing instruments. The vulnerability affects Illumina products with Illumina Universal Copy Service (UCS) v2.x installed: iScan Controls Software (v4.0.0…

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Vulnerabilities Discovered in Illumina DNA Sequencing Devices

Healthcare providers and laboratory personnel have been put on alert after two separate cybersecurity vulnerabilities were discovered in medical devices commonly used in clinical diagnostics and research.

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Illumina Software Raises Critical Warning for Medical Device Vulnerability

The Universal Copy Service (UCS) service in Illumina devices has been found to have critical security gaps that could allow attackers to execute code and take control of the devices, warns the US Cybersecurity and Infrastructure Security Agency (CISA). These devices are widely used worldwide, particularly for DNA sequencing. Attackers…

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Illumina NGS instrument software vulnerable to cybersecurity breach: FDA

The U.S. Food and Drug Administration (FDA) last week warned healthcare providers and laboratory personnel about a cybersecurity vulnerability affecting software in Illumina instruments that may be specified either for clinical diagnostic use in sequencing a person’s DNA for various genetic conditions or for research use only (RUO). The sequencing…

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Critical Vulnerabilities In Illumina Universal Copy Service Devices

1 US CISA warns of critical vulnerabilities affecting the security of Illumina devices. The vulnerabilities exist in the Illumina Universal Copy Service software, allowing remote code execution attacks. Illumina Universal Copy Service Vulnerabilities According to a recent CISA alert, at least two vulnerabilities were discovered in Illumina DNA sequencing devices….

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FDA Warns of Cybersecurity Vulnerabilities in Certain DNA Sequencing Devices

Federal health officials are warning medical facilities that certain diagnostic DNA sequencing devices contain software vulnerabilities, which could make them susceptible to cybersecurity hacks.

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FDA Warns Cybersecurity Vulnerability For Illumina Sequencers

The FDA issued a letter noting that nearly the entire Illumina Inc’s (NASDAQ: ILMN) sequencer lineup carries a cybersecurity vulnerability that could impact genomic data results or even result in a data breach. The agency said that the Universal Copy Service software in the Illumina NovaSeq 6000, NextSeq 500, NextSeq 550, NextSeq 550Dx NextSeq…

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CISA, FDA warn of new Illumina DNA device vulnerability

Several U.S. agencies warned this week about a vulnerability affecting software in devices used for DNA research that would allow hackers access to sensitive patient information. The Food and Drug Administration (FDA) and the company behind the devices — Illumina — said they have not received any reports indicating the…

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CISA Warns of Critical Flaws in Illumina’s DNA Sequencing Instruments

Apr 29, 2023Ravie LakshmananHealthcare / Cybersecurity The U.S. Cybersecurity and Infrastructure Security Agency (CISA) has released an Industrial Control Systems (ICS) medical advisory warning of a critical flaw impacting Illumina medical devices. The issues impact the Universal Copy Service (UCS) software in the Illumina MiSeqDx, NextSeq 550Dx, iScan, iSeq 100,…

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Vulnerability in Illumina genome sequencing medical devices ranked 10.0

A critical vulnerability ranked 10.0 found in certain universal copy service software used in certain Illumina genome sequencing tools could enable a host of nefarious activities, including the remote upload and execution of code at the operating system level. The Cybersecurity and Infrastructure Security Agency (CISA) and the Food and…

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FDA Roundup: April 28, 2023

For Immediate Release: April 28, 2023 Today, the U.S. Food and Drug Administration is providing an at-a-glance summary of news from around the agency:  Today, the FDA issued a final guidance for industry titled Smoking Cessation and Related Indications: Developing Nicotine Replacement Therapy Drug Products, which replaces the draft guidance…

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Illumina Sequencers Face Cybersecurity Vulnerability, FDA Warns

NEW YORK – The US Food and Drug Administration said on Thursday afternoon that nearly the entire Illumina sequencer lineup carries a cybersecurity vulnerability that could impact genomic data results or even result in a data breach. In a letter to healthcare providers and laboratory personnel, the FDA said that…

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Critical-rated security flaw in Illumina DNA sequencing tech exposes patient data

The U.S. government has sounded the alarm about a critical software vulnerability found in genomics giant Illumina’s DNA sequencing devices, which hackers can exploit to modify or steal patients’ sensitive medical data. In separate advisories released on Thursday, U.S. cybersecurity agency CISA and the U.S. Food and Drug Administration warned…

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Vital-rated safety flaw in Illumina DNA sequencing tech exposes affected person information

The U.S. authorities has sounded the alarm a couple of essential software program vulnerability present in genomics large Illumina’s DNA sequencing gadgets, which hackers can exploit to change or steal sufferers’ delicate medical information. In separate advisories launched on Thursday, U.S. cybersecurity company CISA and the U.S. Meals and Drug…

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FDA Issues Warning Regarding Cybersecurity Vulnerability in Illuminas Universal Copy Service Software

As of April 27, 2023, the U.S. Food and Drug Administration (FDA) has issued a warning regarding a cybersecurity vulnerability discovered in Illumina’s Universal Copy Service software. This vulnerability can potentially pose risks to patient health results and customer networks. Fortunately, the FDA has not received any reports indicating the…

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Illumina gets cybersecurity warning from FDA over sequencing software

A cybersecurity vulnerability in Illumina DNA sequencing instruments could allow an unauthorized user to take control of the devices remotely or alter genomic data results, the U.S. Food and Drug Administration said Thursday in a warning to healthcare providers and laboratory personnel. The DNA-sequencing company first notified customers on April 5,…

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CRISPR-clear imaging of melanin-rich B16-derived solid tumors

B16 melanin(+) tdTomato cell line generation The generation and characterization of a lentivirus encoding tdTomato has been described previously22. The B16-D5-HER2 stable cell line was a generous gift from Louis Weiner (Georgetown University)13,23. Cell lines were cultured in DMEM Dulbecco’s modified Eagle’s medium (DMEM; Sigma) supplemented with 10% (v/v) fetal…

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Cambridge: City of Innovation – The ‘beer summit’ that generated a genomic revolution

When you hear Next Generation Sequencing (NGS), you think Illumina Inc. Illumina is widely regarded as the giant of NGS, with an estimated 80% share of the global gene sequencing market. At the heart of Illumina’s nucleic acid sequencing technologies is sequencing-by-synthesis (SBS), a chemistry technology with a humble and…

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Innovative technologies crowd the short-read sequencing market

There’s an old saying in the field of technology: “Nobody ever got fired for buying IBM” — a reference to the company’s once-ubiquitous computers. Replace IBM with Illumina, a biotechnology company in San Diego, California, and the same could be said of DNA sequencing today. Keith Robison, a computational biologist…

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A Look At Ion Torrent (and some chips)

I’ve been looking at a few Ion Torrent chips. Ion Torrent hasn’t been a massive commercial success, but the Ion Torrent PGM was an important instrument for a number of reasons. So let’s talk about Ion Torrent! (if you just want to see chip pictures, scroll to the end). First…

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Next Generation Sequencing Market Business Strategies,

Next Generation Sequencing Market The Business Research Company’s global market reports are now updated with the latest market sizing information for the year 2023 and forecasted to 2032 As per the next-generation sequencing market report by The Business Research Company, the growing number of cases with chronic conditions such as…

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Aptorum Group Ltd. (APM) Updates on the Clinical Validation of RPIDD Infectious Disease Liquid Biopsy Molecular Diagnostics

Get instant alerts when news breaks on your stocks. Claim your 1-week free trial to StreetInsider Premium here. Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) a clinical stage biopharmaceutical company dedicated to tackling unmet medical needs in oncology, autoimmune diseases and infectious diseases, is pleased to announce further updates…

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CISA Warned About Critical Vulnerabilities in Illumina’s DNA Sequencing Devices

The U.S. Cybersecurity and Infrastructure Security Agency (CISA) and Food and Drug Administration (FDA) have issued an advisory about critical security vulnerabilities in Illumina’s next-generation sequencing (NGS) software. Three of the flaws are rated 10 out of 10 for severity on the Common Vulnerability Scoring System (CVSS), with two others…

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Error rates could not be estimated — unsure why – Technical Support

I’m running dada2 on paired end data and getting the same error over and over again. My data are from an 150 PE run on an Illumina iSeq machine, sequencing a 16s fragment for vertebrates. The samples were demultiplexed by Casava based on the i5 and i7 adapters. Some samples…

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Bioconductor – iSeq

Bayesian Hierarchical Modeling of ChIP-seq Data Through Hidden Ising Models Bioconductor version: 2.7 This package uses Bayesian hidden Ising models to identify IP-enriched genomic regions from ChIP-seq data. It can be used to analyze the ChIP-seq data with or without controls. Author: Qianxing Mo Maintainer: Qianxing Mo <moq at mskcc.org>…

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Strong within-host selection in a maternally inherited obligate symbiont: Buchnera and aphids

Significance Many animals depend on maternally transmitted symbiotic bacteria that provide nutrients or other benefits. The evolution of these symbionts is complicated: natural selection can act on hosts, favoring symbionts that increase host reproduction, or on symbionts, favoring symbionts that spread within hosts. Furthermore, transmission bottlenecks can facilitate the spread…

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