Tag: junk DNA

Study shows how genes in retina get regulated during development

Dec. 17—Researchers at the National Institutes of Health have mapped the 3D organization of genetic material of key developmental stages of human retinal formation, using intricate models of a retina grown in the lab. The findings lay a foundation for understanding clinical traits in many eye diseases, and reveal a…

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How genes in retina get regulated during development

Researchers at the National Institutes of Health have mapped the 3D organization of genetic material of key developmental stages of human retinal formation, using intricate models of a retina grown in the lab. The findings lay a foundation for understanding clinical traits in many eye diseases, and reveal a highly…

Continue Reading How genes in retina get regulated during development

Functions Support the New RNA Gene Paradigm

Photo credit: THAVIS 3D via Unsplash. In recent days I have covered a new paper published in BioEssays by Australian molecular biologist John Mattick who cites the need for a “paradigm shift” in biology away from the concept of junk DNA (see here, here, and here). I recounted how this shift is being driven by…

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Researchers from UC San Diego Introduce EUGENe: An Easy-to-Use Deep Learning Genomics Software

Deep learning is being used in all spheres of life. It has its utility in every field. It has a big impact on biomedical research. It is like a smart computer that can get better at tasks with little help. It has changed the way scientists study medicine and diseases….

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The mysterious role of ancient viruses embedded in human DNA | Health

In the blueprint for life that is the human genome, there are some mysterious, silent particles. They perform no function and have gone unnoticed for thousands and thousands of years. They are species of ancestral viruses, remnants of ancient pandemics, that became embedded in the DNA of germ cells (that…

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Researchers reveal key role of ASD-risk factor POGZ in control of 2C program and retrotransposon elements

Graphical abstract. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112867 A significant portion of mammalian genomes are composed of retrotransposable elements (REs). Unlike the previous hypothesis that these are “junk DNA,” recent studies have shown that REs such as endogenous retroviruses (ERVs) and long interspersed nuclear element 1 (LINE1) play essential roles…

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Infertility, other health problems could be tied to Y chromosome

Scientists have fully sequenced the Y chromosome for the first time, uncovering information that could have implications for the study of male infertility and other health problems. The first attempt to determine the building blocks of our genetic code took place 20 years ago, but there were still…

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The ‘Weird’ Male Y Chromosome Has Finally Been Fully Sequenced

An anonymous reader quotes a report from The Conversation: The Y chromosome is a never-ending source of fascination (particularly to men) because it bears genes that determine maleness and make sperm. It’s also small and seriously weird; it carries few genes and is full of junk DNA that makes it…

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Scientists successfully sequence the Y chromosome for the first time

In a momentous feat poised to reshape our understanding of human biology, scientists have achieved a landmark by successfully decoding the Y chromosome for the very first time. This milestone bears the potential to unearth crucial insights into human genetic material, which could potentially revolutionize the exploration of male infertility…

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Explained | Scientists finally decipher enigmatic Y chromosome, feat to help study male infertility

In a significant achievement set to redefine the realm of human biology, scientists have successfully sequenced the Y chromosome for the first time. The breakthrough translates into the unearthing of valuable information about human genetic material that could revolutionise the study of male infertility and various health disorders. Initial attempts…

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The Male Y Chromosome Has Finally Been Completely Sequenced

Image by Getty / Futurism The human Y chromosome, the determinant of male sex, has finally been completely sequenced. What it unveils could prove crucial to understanding the Y chromosome’s puzzling origins, and — pertinently — how it affects male fertility. You can thank two teams of researchers for the breakthrough,…

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Scientists Fully Sequence Y Chromosome for the First Time In Major Men’s Health Breakthrough

For the first time, scientists have fully sequenced a Y chromosome. Scientists say that this advancement could have great implications for the future of men’s health and offer insights into health problems like infertility. An international group of 100 scientists called the Telomere-to-Telomere Consortium came together last year looking to…

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Scientists fully sequence human Y chromosome for the first time

Sign up for CNN’s Wonder Theory science newsletter. Explore the universe with news on fascinating discoveries, scientific advancements and more. CNN  —  Scientists have fully sequenced the Y chromosome for the first time, uncovering information that could have implications for the study of male infertility and other health problems. The first…

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Genomics Revolutionizing Hospital Systems – By Ram Ramanujam

Genomics Revolutionizing Hospital Systems Bleeding edge Industrialization of Genomics: A Novel Business Opportunity to a Hospital System – to Calibrate by Whole Genome DNA Analytics, the Efficacy of Chemotherapy Drugs: Wider Global implications. Guest Article – By Ram Ramanujam, Founder-President &CEO, Propinquity Therapeutics, A RNA CGT Company, Bangalore, India. The…

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Intragenomic rDNA variation – the product of concerted evolution, mutation, or something in between?

Adams KL, Wendel JF (2005) Polyploidy and genome evolution in plants. Curr Opin Plant Biol 8(2):135–141 Article  CAS  PubMed  Google Scholar  Ambrose CD, Crease TJ (2011) Evolution of the nuclear ribosomal DNA intergenic spacer in four species of the Daphnia pulex complex. BMC Genet 12:13 Article  CAS  PubMed  PubMed Central …

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Fractal Genome – Post Genome Era Analytics

Fractal Genome: Post Genome Era Analytics To Rescue India’s opportunities in IT-led Pharma Biotech. Guest Author: Ram M.V. Ramanujam, President-Founder and CEO, Propinquity Therapeutics, Bangalore, India. Genomics Pioneers and mathematical approaches in Biology are illustrative as the papers revealed that a repetitive self-similar process governs how the fractal genome is….

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As expected, wine grapes found to have high deleterious genetic burden

A region containing a Fer-like gene was predicted to have introgressed from the EU and under selection. (A) A cluster of the malectin/receptor-like protein kinase domain was observed around the introgressed region. The malectin domain is represented by blue boxes. The red boxes indicate the CDS of the candidate Fer-like…

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SickKids scientists shine light on the complex genetics that underlie blood pressure regulation

Scientists at The Hospital for Sick Children (SickKids) are delving deep into the non-coding genome to unravel the complex genetics that underlie blood pressure regulation and hypertension (high blood pressure) – the leading cause of cardiovascular disease affecting 1.25 billion people worldwide. While the human genome comprises coding and non-coding…

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Molecular Explanation For How One Woman Doesn’t Feel Pain And Heals Rapidly

Jo Cameron is a woman who doesn’t feel pain but is also spared the usual consequences, thanks to rare mutations. She also experiences less anxiety or fear than other people. A study of the molecular basis of her condition could yield medical benefits for the rest of us. Not feeling pain…

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LincRNA discovery could lead to targeted treatments

Our genetic code includes more than 15,000 specific sections that can be made into molecules called lincRNAs. Some of these sections can occur in coiled-up sections of our genome called topologically associating domains, or TADs.  LincRNAs derived from TADs appear to act as markers indicating the specific kind of tissue…

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Keyword: ncrna

Once considered unimportant “junk DNA,” scientists have learned that non-coding RNA (ncRNA) — RNA molecules that do not translate into proteins — play a crucial role in cellular function. Mutations in ncRNA are associated with a number of conditions, such as cancer, autism, and Alzheimer’s disease. Now, through the use…

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Do We Really Need All This Junk DNA? Israeli Study Says Yes

Why is ‘junk DNA’ not deleted from the original genome over millions of years of evolution? A bold new hypothesis developed by Tel Aviv University scientists offers a possible solution to the question of why neutral sequences, also known as “junk DNA,” continue to exist within the human genome for…

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ChatGPT totally fails my one-question exam on Junk DNA

I was chatting with HJ Hornbeck and Dr Sarah yesterday, and we were tinkering with ChatGPT. We asked it for some simple medical advice, of the sort you might consult WebMD for, and Dr Sarah confirmed that it was close to what she would recommend. Then we asked it a…

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Limit Fragment Duration Polymorphisms (RFLP) Style of DNA Profiling

Limit Fragment Duration Polymorphisms (RFLP) Style of DNA Profiling Conceptual The amazing strength regarding DNA technical as the a recognition product got lead a tremendous change in crimnal fairness . DNA studies legs is an information capital into forensic DNA typing neighborhood having informative data on popular quick tandem repeat…

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The CRISPR Family Tree Holds a Multitude of Untapped Gene Editing Tools

Thanks to CRISPR, gene therapy and “designer babies” are now a reality. The gene editing Swiss army knife is one of the most impactful biomedical discoveries of the last decade. Now a new study suggests we’ve just begun dipping our toes into the CRISPR pond. CRISPR-Cas9 comes from lowly origins….

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How Ancient Virus DNAs Are Guarding Marsupials From Modern Diseases

Incorporating viruses that previously endangered their life into their non-coding or “junk” DNA, marsupials have made friends with ancient adversaries. Researchers have discovered multiple lines of evidence suggesting that these sections of DNA guard against viruses that are identical to the originals – and that they do it extremely efficiently….

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Ancient marsupial ‘junk DNA’ might be useful after all, scientists say

Viral fossils buried in DNA may protect against future virus infections, a new marsupial study suggests. Fossils of ancient viruses are preserved in the genomes of all animals, including humans, and have long been regarded as junk DNA. But are they truly junk, or do they actually serve a useful…

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Quanta Magazine

Imagine the human genome as a string stretching out for the length of a football field, with all the genes that encode proteins clustered at the end near your feet. Take two big steps forward; all the protein information is now behind you. The human genome has three billion base…

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