Categories
Tag: KO
KEGG T07682: 118706260
Entry 118725205 ncRNA T07682 Name (RefSeq) U1 spliceosomal RNA KO K14276 U1 spliceosomal RNA Organism pkl Pipistrellus kuhlii (Kuhl’s pipistrelle) Pathway pkl03040 Spliceosome Brite KEGG Orthology (KO) [BR:pkl00001] 09120 Genetic Information Processing 09121 Transcription 03040 Spliceosome 118725205 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03041 Spliceosome [BR:pkl03041] 118725205 09184 RNA family 03100 Non-coding RNAs [BR:pkl03100] 118725205Spliceosome [BR:pkl03041] Splicing related RNAs 118725205Non-coding RNAs [BR:pkl03100] Small non-coding…
KEGG T01015: 4329963
Entry 4332822 CDS T01015 Name (RefSeq) LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 1-like KO K12882 nuclear cap-binding protein subunit 1 Organism osa Oryza sativa japonica (Japanese rice) (RefSeq) Pathway osa03013 Nucleocytoplasmic transport osa03015 mRNA surveillance pathway osa03040 Spliceosome Brite KEGG Orthology (KO) [BR:osa00001] 09120 Genetic Information Processing 09121 Transcription 03040 Spliceosome 4332822 09122 Translation 03013 Nucleocytoplasmic transport 4332822 03015 mRNA…
KEGG ORTHOLOGY: K06121
KEGG ORTHOLOGY: K06121 ORTHOLOGY: K06121 Help Entry K06121 KO Symbol dhbC Name glycerol dehydratase medium subunit [EC:4.2.1.30] Pathway Reaction R01047 glycerol hydro-lyase (3-hydroxypropanal-forming) Brite KEGG Orthology (KO) [BR:ko00001] 09100 Metabolism 09103 Lipid metabolism 00561 Glycerolipid metabolism K06121 dhbC; glycerol dehydratase medium subunitEnzymes [BR:ko01000] 4. Lyases 4.2 Carbon-oxygen lyases 4.2.1 Hydro-lyases 4.2.1.30 glycerol dehydratase K06121 dhbC; glycerol dehydratase medium subunit BRITE hierarchy Other DBs Genes…
KEGG T01710: 100306272
Entry 100782702 CDS T01710 Symbol COX2 Name (RefSeq) cytochrome c oxidase subunit 2, mitochondrial KO K02261 cytochrome c oxidase subunit 2 Organism gmx Glycine max (soybean) Pathway gmx00190 Oxidative phosphorylation gmx01100 Metabolic pathways Brite KEGG Orthology (KO) [BR:gmx00001] 09100 Metabolism 09102 Energy metabolism 00190 Oxidative phosphorylation 100782702 (COX2) 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03029 Mitochondrial biogenesis…
Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly
Capturing proteins associated with SARS-CoV-2 virions To identify host cell proteins potentially present in extracellular SARS-CoV-2 virions, viral particles were produced from two lung epithelial cell models, A549 cells overexpressing ACE2 receptor (A549-ACE2) and Calu-3 cells that naturally express ACE2 receptor and TMPRSS2. Following infection with the D614G SARS-CoV-2 strain32,…
Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice
Background: IgE has been known for mediating endothelial cell dysfunction and mast cell (MC) activation to fuel asthma-aggravated high-fat diet-induced atherosclerosis. However, it remains unclear for the mechanism of asthma-mediated atherosclerosis, especially the potential involvement of IgE in the exacerbation of asthma-mediated atherosclerosis with a standard laboratory diet, and the…
Ten NK cell therapy companies to look out for this year
Natural killer (NK) cells are white blood cells that are a part of the body’s defense mechanism. These cells are on the lookout for any kind of disruption in the immune system, and can kill diseased cells like tumor cells. NK cells are being used in clinical applications to treat…
Knockout of lipoprotein lipase with CRISPR/Cas9 causes severe developmental defects and affects lipid deposition in Japanese medaka (Oryzias latipes)
Abstract In mammals, lipoprotein lipase (LPL) has been found to play an important role in lipid mentalism and deposition. LPL deficiency in humans (Homo sapiens) and mice (Mus musculus) tends to cause hypertriglyceridemia. The lpl gene is not expressed in adult mammalian liver, but is in adult fish liver. The…
csi-miR-96-5p delivered by Clonorchis sinensis extracellular vesicles promotes intrahepatic cholangiocarcinoma proliferation and migration via the ferroptosis-related PTEN/SLC7A11/GPX4 axis | Parasites & Vectors
Human tissue samples The preoperative diagnosis of CS mainly relies on stool microscopy, enzyme-linked immunosorbent assay, or endoscopy. Fresh liver and intrahepatic bile duct specimens were collected from ICC patients with (CS-ICC group) and without (NC-ICC group) CS infection during partial hepatectomy at the First Hospital of Jilin University. Tumor tissues…
Summary of Genomics and Transcriptomics – DNA sequencing I. Goal II. Methodology A. Sanger DNA
DNA sequencing I. Goal II. Methodology A. Sanger DNA sequencing ● Up to 900 base pairs ● Primer extension with labeled ddNTPs (radioactive or fluorescent) ● Prior knowledge on target needed ● Difficult to detect variation in mixtures ● High accuracy + still in use for genotyping When it is…
KEGG T08053: IA203_01755
Entry IA203_01755 CDS T08053 Name (GenBank) UDP-N-acetylmuramate dehydrogenase KO K00075 UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] Organism cwk Corynebacterium wankanglinii Pathway cwk00520 Amino sugar and nucleotide sugar metabolism cwk00550 Peptidoglycan biosynthesis cwk01100 Metabolic pathways cwk01250 Biosynthesis of nucleotide sugars Brite KEGG Orthology (KO) [BR:cwk00001] 09100 Metabolism 09101 Carbohydrate metabolism 00520 Amino sugar and nucleotide sugar metabolism IA203_01755 09107 Glycan biosynthesis and…
KEGG T09148: BWI76_09435
Entry BWI76_09435 CDS T09148 Name (GenBank) glutaredoxin, GrxA family KO K03674 glutaredoxin 1 Organism klm Klebsiella sp. M5al Brite KEGG Orthology (KO) [BR:klm00001] 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03110 Chaperones and folding catalysts [BR:klm03110] BWI76_09435Chaperones and folding catalysts [BR:klm03110] Protein folding catalysts Protein disulfide isomerase BWI76_09435 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam: Glutaredoxin Glrx-like Thioredoxin_3…
Kris Bernal reacts to viral hairstyle from ‘Starstruck’
Kris Bernal couldn’t help but laugh at her hair mishap from years ago. A video of the actress and content creator from her time competing on “Starstruck” is making the rounds online. Posted on GMA Network’s Instagram page, it showed Kris getting a very short haircut with uneven bangs and…
Sequential deregulation of histone marks, chromatin accessibility and gene expression in response to PROTAC-induced degradation of ASH2L
Loss of ASH2L prevents cell proliferation We have studied the molecular and cellular consequences of Ash2l loss in mouse embryo fibroblasts (MEFs) with floxed Ash2l alleles and an inducible Cre-ER recombinase (iMEF-Ash2lfl/fl-Cre-ER). While the knockout of Ash2l was rapid, the downstream effects, including the decrease in promoter-associated H3K4me3, altered gene…
Functional alterations and predictive capacity of gut microbiome in type 2 diabetes
Diversity and compositional analyses Regarding clinical differences (Table 1), T2DM individuals (mean 69.6 (± 12.3 sd) years) were significantly (p value < 0.01; Wilcoxon rank-sum test) older than the controls (46.9 (± 17.3 sd) years), showed higher BMI (mean 30.9 (± 7.01 sd) vs. mean 26.3 (± 6.12 sd) than the control…
Identification of Differentially Expressed Genes in Human Colorectal Cancer Using RNASeq Data Validated on the Molecular Level with Real-Time PCR
Allam RM, Al-Abd AM, Khedr A, Sharaf OA, Nofal SM, Khalifa AE, Mosli HA, Abdel-Naim AB (2018) Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells. Toxicol Lett 291:77–85 Article CAS PubMed Google Scholar Andrews S et al (2010) FastQC: a quality control tool…
LOINC 16531-6 Campylobacter lari rRNA [Units/volume] in Serum by Probe
es-AR Spanish (Argentina) ARNr de Campylobacter lari:concentración arbitraria:punto en el tiempo:suero:cuantitativo:sonda es-ES Spanish (Spain) Campylobacter lari rRNA:Concentración arbitraria:Punto temporal:Suero:Qn:Sonda de DNASynonyms: Cuantitativo es-MX Spanish (Mexico) ARNr de Campylobacter lari:Concentración arbitraria:Punto temporal:Suero:Cuantitativo:Investigacion fr-CA French (Canada) Campylobacter lari , ARNr:Concentration arbitraire:Temps ponctuel:Sérum:Quantitatif:Sonde fr-FR French (France) Campylobacter lari ARNr:Arbitraire/Volume:Ponctuel:Sérum:Numérique:PCR fr-BE French (Belgium) Campylobacter…
Evolution of lysine-specific demethylase 1 and REST corepressor gene families and their molecular interaction
The RCOR gene repertoire expanded in the ancestor of jawed vertebrates To understand the duplicative history of the RCOR genes, we reconstructed gene phylogenies with different taxonomic samplings. The first analysis aimed to understand the evolution of RCOR genes in vertebrates (Fig. 2), whereas in the second, our sampling effort included…
Cancers | Free Full-Text | In Vitro Organoid-Based Assays Reveal SMAD4 Tumor-Suppressive Mechanisms for Serrated Colorectal Cancer Invasion
Original submission received: 21 November 2023 / Revised: 8 December 2023 / Accepted: 11 December 2023 / Published: 13 December 2023 Round 1 Reviewer 1 Report Comments and Suggestions for Authors Dear authors, thank you for this valuable piece of work. Should the other reviewer(s) recommend edits to your work,…
Importance of a detailed anomaly scan after a cfDNA test indicating fetal trisomy 21, 18 or 13
Kagan KO, Sonek J, Kozlowski P (2022) Antenatal screening for chromosomal abnormalities. Arch Gynecol Obstet 305(4):825–835 Article CAS PubMed PubMed Central Google Scholar Rose NC, Barrie ES, Malinowski J, Jenkins GP, McClain MR, LaGrave D et al (2022) Systematic evidence-based review: the application of noninvasive prenatal screening using cell-free DNA…
Atg7 senses ATP levels and regulates AKT1-PDCD4 phosphorylation-ubiquitination axis to promote survival during metabolic stress
Atg7 interacts with PDCD4 and negatively regulates PDCD4 protein levels Previous studies have demonstrated the role of Atg7 in maintaining metabolic homeostasis by initiating autophagy and arresting the cell cycle17,18,22. Herein, the function of Atg7 was more comprehensively investigated and it was determined whether Atg7 reduces protein synthesis to save…
Insight into chloroplast genome structural variation of the Mongolian endemic species Adonis mongolica (Ranunculaceae) in the Adonideae tribe
Wang, W. T. Revision of Adonis (Ranunculaceae). Bull. Bot. Res. 14, 1–31 (1994). Google Scholar Gao, T. et al. Evaluating the feasibility of using candidate DNA Barcodes in discriminating species of the large Asteraceae family. BMC Evol. Biol. 10, 324 (2016). Article Google Scholar Conti, F. et al. Adonis fucensis…
Glabridin improves autoimmune disease in Trex1-deficient mice by reducing type I interferon production | Molecular Medicine
Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley GL, Vandesompele J, Wittwer CT. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem. 2009;55:611–22. Article CAS PubMed Google Scholar Chen Q, Sun L, Chen ZJ….
LOINC 17546-3 Bartonella quintana rRNA [Presence] in Specimen by Probe
de-DE German (Germany) Bartonella quintana rRNA:Nachweis oder Schwellenwert:Zeitpunkt:XXX:Ordinal:Sonde es-AR Spanish (Argentina) ADN de Bartonella quintana:concentración arbitraria:punto en el tiempo:XXX:ordinal:sonda es-ES Spanish (Spain) Bartonella quintana rRNA:PrThr:Punto temporal:XXX:Ord:Sonda de DNA es-MX Spanish (Mexico) ARNr de Bartonella quintana:Presencia o umbral:Punto temporal:XXX:Ordinal:Investigacion fr-CA French (Canada) Bartonella quintana , ARNr:Présence-Seuil:Temps ponctuel:XXX:Ordinal:Sonde fr-FR French (France) Bartonella…
Psychological impact of additional findings detected by genome-wide Non-Invasive Prenatal Testing (NIPT): TRIDENT-2 study
Lo YMD, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CWG, et al. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997;350:485–7. Article CAS PubMed Google Scholar Warsof SL, Larion S, Abuhamad AZ. Overview of the impact of noninvasive prenatal testing on diagnostic procedures. Prenat Diagn. 2015;35:972–9….
Advanced Emerging Techniques for Forensic DNA Analysis: STRs, SNPs, and mtDNA Analysis
Alshehhi A, Almarzooqi A, Alhammadi K, Werghi N, Tay GK, Alsafar H (2023) Advancement in human face prediction using DNA. Genes (Basel) 14:136. doi.org/10.3390/genes14010136 CrossRef CAS PubMed Google Scholar Amorim A, Fernandes T, Taveira N (2019) Mitochondrial DNA in human identification: a review. PeerJ 7:e7314. doi.org/10.7717/peerj.7314 CrossRef PubMed Central PubMed …
Map of disease-causing mutations in neurodevelopmental disorders and cancer revealed
Experimental design overview. a Two independent sgRNAs and associated HDR variant libraries are designed at the 5′ and 3′ end of each exon. b The sgRNA, together with the HDR template library are transfected into LIG4-KO Cas9-expressing HAP1 cells. HDR utilizes the library as a template for repair of the…
tRNA therapeutics for genetic diseases
Huang, X. et al. The landscape of mRNA nanomedicine. Nat. Med. 28, 2273–2287 (2022). Article CAS Google Scholar Rohner, E., Yang, R., Foo, K. S., Goedel, A. & Chien, K. R. Unlocking the promise of mRNA therapeutics. Nat. Biotechnol. 40, 1586–1600 (2022). Article CAS Google Scholar Brown, A., Shao, S.,…
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy | Military Medical Research
Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knöpper K, et al. MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature. 2022;609(7926):354–60. Article CAS PubMed PubMed Central Google Scholar Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, et al. Dapl1 controls NFATc2…
Developing more advanced renal organoids to model polycystic kidney disease
Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113431 A team of CiRA researchers, building upon their previous work on differentiating iPS cells into kidney organoids, have made significant improvements to build a better model of kidney development and diseases for use as a robust platform for drug discovery. Autosomal dominant polycystic kidney…
KEGG ORTHOLOGY: K17062
KEGG ORTHOLOGY: K17062 ORTHOLOGY: K17062 Help Entry K17062 KO Symbol bgtB Name arginine/lysine/histidine/glutamine transport system substrate-binding and permease protein Pathway Brite KEGG Orthology (KO) [BR:ko00001] 09130 Environmental Information Processing 09131 Membrane transport 02010 ABC transporters K17062 bgtB; arginine/lysine/histidine/glutamine transport system substrate-binding and permease protein 09180 Brite Hierarchies 09183 Protein families: signaling and cellular processes 02000 Transporters K17062 bgtB; arginine/lysine/histidine/glutamine transport…
KEGG ORTHOLOGY: K06665
KEGG ORTHOLOGY: K06665 ORTHOLOGY: K06665 Help Entry K06665 KO Symbol SSN6, CYC8 Name general transcriptional corepressor CYC8 Pathway map04011 MAPK signaling pathway – yeast Brite KEGG Orthology (KO) [BR:ko00001] 09130 Environmental Information Processing 09132 Signal transduction 04011 MAPK signaling pathway – yeast K06665 SSN6, CYC8; general transcriptional corepressor CYC8 09140 Cellular Processes 09143 Cell growth and death 04111…
How can we use the organism database created by makeorgPackageFromNCBI to KEGG and GO analysis using clusterprofiler package.
How can we use the organism database created by makeorgPackageFromNCBI to KEGG and GO analysis using clusterprofiler package. 0 @3e18707b Last seen 10 hours ago India I have transcriptome data of an inhouse sequenced bacterial genome. I made the database for my bacteria using makeOrgPackageFromNCBI command. How can I use…
A Reliable Method for Quantifying Plasma Cell-Free DNA Using an Internal Standard Strategy: Evaluation in a Cohort of Non-Pregnant and Pregnant Women
Martignano F. Cell-free DNA: an overview of sample types and isolation procedures. In: Casadio V, Salvi S, editors. Cell-free DNA as diagnostic markers. Methods in molecular biology, Vol. 1909. New York, NY: Humana Press; 2019. p. 13–27. doi.org/10.1007/978-1-4939-8973-7_2. Volckmar AL, Sültmann H, Riediger A, Fioretos T, Schirmacher P, Endris V,…
Potential use of iPSCs for disease modeling, drug screening, and cell-based therapy for Alzheimer’s disease | Cellular & Molecular Biology Letters
Tarawneh R, Holtzman DM. The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment. Cold Spring Harb Perspect Med. 2012;2(5): a006148. Article PubMed PubMed Central Google Scholar van der Flier WM, Scheltens P. Epidemiology and risk factors of dementia. J Neurol Neurosurg Psychiatry. 2005;76(suppl 5):v2-7. Article PubMed PubMed Central …
KEGG T01005: 473325
Entry 473325 CDS T01005 Symbol RNASE2 Name (RefSeq) non-secretory ribonuclease precursor KO K01168 pancreatic ribonuclease [EC:4.6.1.18] Organism ptr Pan troglodytes (chimpanzee) Brite KEGG Orthology (KO) [BR:ptr00001] 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03019 Messenger RNA biogenesis [BR:ptr03019] 473325 (RNASE2) 04131 Membrane trafficking [BR:ptr04131] 473325 (RNASE2)Enzymes [BR:ptr01000] 4. Lyases 4.6 Phosphorus-oxygen lyases 4.6.1 Phosphorus-oxygen lyases (only sub-subclass identified to date) 4.6.1.18 pancreatic ribonuclease 473325 (RNASE2)Messenger…
Precise base editing without unintended indels in human cells and mouse primary myoblasts
Base editors cause unintended indels at the target sites Several types of evolved base editors based on the CRISPR system have been developed for more accurate and efficient genome engineering21,37. Among these, AncBE4max and ABEmax were evolved by modifying codon usage, NLSs, and ancestral deaminase reconstructions21. These modifications greatly improve…
DNA methylation change in blood cells of FB and CFS patients
Introduction Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) are characterized by chronic pain, fatigue, and weakness. Patients with these symptoms also suffer from sleep abnormalities and report affected cognitive processes such as memory. The diagnosis of these two syndromes is challenging and is based on questionnaires that make the diagnosis…
KEGG T01007: 415125
Entry 415125 CDS T01007 Symbol FGFR2 Name (RefSeq) fibroblast growth factor receptor 2 precursor KO K05093 fibroblast growth factor receptor 2 [EC:2.7.10.1] Organism cfa Canis lupus familiaris (dog) Pathway cfa01521 EGFR tyrosine kinase inhibitor resistance cfa04010 MAPK signaling pathway cfa04014 Ras signaling pathway cfa04015 Rap1 signaling pathway cfa04020 Calcium signaling pathway cfa04144 Endocytosis…
KEGG T02994: 18601618
Entry 18601618 CDS T02994 Name (RefSeq) alpha-glucan phosphorylase 1 KO K00688 glycogen phosphorylase [EC:2.4.1.1] Organism tcc Theobroma cacao (cacao) Pathway tcc00500 Starch and sucrose metabolism tcc01100 Metabolic pathways tcc01110 Biosynthesis of secondary metabolites Brite KEGG Orthology (KO) [BR:tcc00001] 09100 Metabolism 09101 Carbohydrate metabolism 00500 Starch and sucrose metabolism 18601618Enzymes [BR:tcc01000] 2. Transferases 2.4 Glycosyltransferases 2.4.1 Hexosyltransferases 2.4.1.1 glycogen phosphorylase 18601618 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT…
KEGG T00196: STH138
Entry STH138 CDS T00196 Name (GenBank) putative N-acetyl-mannosamine transferase KO K05946 N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase [EC:2.4.1.187] Organism sth Symbiobacterium thermophilum Pathway sth00552 Teichoic acid biosynthesis Brite KEGG Orthology (KO) [BR:sth00001] 09100 Metabolism 09107 Glycan biosynthesis and metabolism 00552 Teichoic acid biosynthesis STH138 09180 Brite Hierarchies 09181 Protein families: metabolism 01003 Glycosyltransferases [BR:sth01003] STH138Enzymes [BR:sth01000] 2. Transferases 2.4 Glycosyltransferases 2.4.1 Hexosyltransferases 2.4.1.187 N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase STH138Glycosyltransferases [BR:sth01003] Polysaccharide Bacterial polysaccharide (excluding LPS) STH138 BRITE hierarchy SSDB…
Proteomics and metabolomics analyses of Streptococcus agalactiae isolates from human and animal sources
Shen, C.-H. Molecular diagnosis of infectious diseases in Diagnostic Molecular Biology Ch. 15, 387–411 (Academic Press, C 2019). Katholm, J., Bennedsgaard, T. W., Koskinen, M. T. & Rattenborg, E. Quality of bulk tank milk samples from Danish dairy herds based on real-time polymerase chain reaction identification of mastitis pathogens. J….
KEGG T02920: 102247935
Entry 102247935 CDS T02920 Symbol TRMT44 Name (RefSeq) tRNA methyltransferase 44 homolog (S. cerevisiae) KO K15447 tRNASer (uridine44-2′-O)-methyltransferase [EC:2.1.1.211] Organism myb Myotis brandtii (Brandt’s bat) Brite KEGG Orthology (KO) [BR:myb00001] 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03016 Transfer RNA biogenesis [BR:myb03016] 102247935 (TRMT44)Enzymes [BR:myb01000] 2. Transferases 2.1 Transferring one-carbon groups 2.1.1 Methyltransferases 2.1.1.211 tRNASer (uridine44-2′-O)-methyltransferase 102247935 (TRMT44)Transfer RNA biogenesis [BR:myb03016] Eukaryotic type tRNA modification…
Cytoplasmic Escape of Mitochondrial DNA Mediated by Mfn2 Downregulation Promotes Microglial Activation via cGas-Sting Axis in Spinal Cord Injury
doi: 10.1002/advs.202305442. Online ahead of print. Fei-Long Wei 1 , Tian-Fu Wang 1 , Chao-Li Wang 2 , Zhen-Peng Zhang 3 , Jing-Wei Zhao 1 , Wei Heng 1 , Zhen Tang 1 , Ming-Rui Du 1 , Xiao-Dong Yan 1 , Xiao-Xiang Li 1 , Zheng Guo 1 , Ji-Xian Qian 1 , Cheng-Pei Zhou 1 Affiliations Expand Affiliations 1 Department…
KEGG T03531: KR75_11080
Entry KR75_11080 CDS T03531 Name (GenBank) xylose isomerase KO K01805 xylose isomerase [EC:5.3.1.5] Organism kvd Klebsiella variicola DX120E Pathway kvd00040 Pentose and glucuronate interconversions kvd00051 Fructose and mannose metabolism kvd01100 Metabolic pathways Brite KEGG Orthology (KO) [BR:kvd00001] 09100 Metabolism 09101 Carbohydrate metabolism 00040 Pentose and glucuronate interconversions KR75_11080 00051 Fructose and mannose metabolism KR75_11080Enzymes [BR:kvd01000] 5. Isomerases 5.3 Intramolecular oxidoreductases 5.3.1 Interconverting aldoses and…
KEGG T01001: 1474
Entry 1474 CDS T01001 Symbol CST6, ECTD15 Name (RefSeq) cystatin E/M KO K13902 cystatin-M Organism hsa Homo sapiens (human) Disease H00651 Hypohidrotic ectodermal dysplasia Brite KEGG Orthology (KO) [BR:hsa00001] 09180 Brite Hierarchies 09181 Protein families: metabolism 01002 Peptidases and inhibitors [BR:hsa01002] 1474 (CST6)Peptidases and inhibitors [BR:hsa01002] Peptidase inhibitors Family I25: cystatin family 1474 (CST6) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif…
KEGG T01001: 637
Entry 637 CDS T01001 Symbol BID, FP497 Name (RefSeq) BH3 interacting domain death agonist KO K04726 BH3 interacting domain death agonist Organism hsa Homo sapiens (human) Pathway hsa01524 Platinum drug resistance hsa04071 Sphingolipid signaling pathway hsa04115 p53 signaling pathway hsa04210 Apoptosis hsa04215 Apoptosis – multiple species hsa04217 Necroptosis hsa04650 Natural killer cell mediated…
Complex design with a mixture of male and female mice
DEseq2 : Complex design with a mixture of male and female mice 0 @2bfe541c Last seen 4 hours ago France Hello everyone, I’m working on a scientific project that poses a particular problem. The experimental design includes 3 times and 2 conditions (WT and KO). Each time*condition has 3 mice….
Immune-privileged tissues formed from immunologically cloaked mouse embryonic stem cells survive long term in allogeneic hosts
Mice C57BL/6N (strain 005304), C3H/HeJ (strain 000659), FVB/NJ (strain 001800), BALB/cJ (strain 000651) and NSG mice (stock 005557) were purchased from the Jackson Laboratory. CD-1 (stock 022) mice were purchased from Charles River. Mice (6–20-week-old) of each strain/background were used for teratoma assays. Mice were housed in a pathogen-free facility…
High-throughput screening of genetic and cellular drivers of syncytium formation induced by the spike protein of SARS-CoV-2
Plasmid construction All the constructs used in this study were generated with standard cloning strategies, including PCR, overlapping PCR, oligo annealing, digestion and ligation. Primers were purchased from Genewiz. The plasmid sequence was verified by Sanger sequencing. The pCAG-spike(D614G)-GFP11-mCherry plasmid was modified from Addgene plasmid 158761. Briefly, GFP11 and mCherry…
Gene expression profiles separate endometriosis lesion subtypes and indicate a sensitivity of endometrioma to estrogen suppressive treatments through elevated ESR2 expression | BMC Medicine
Cea Soriano L, López-Garcia E, Schulze-Rath R, Garcia Rodríguez LA. Incidence, treatment and recurrence of endometriosis in a UK-based population analysis using data from The Health Improvement Network and the Hospital Episode Statistics database. Eur J Contracept Reprod Health Care. 2017;22(5):334–43. Article PubMed Google Scholar Guo SW. Recurrence of endometriosis…
Megakaryocytes possess a STING pathway that is transferred to platelets to potentiate activation
Introduction Host defence against infection relies on two important systems: the immune and the coagulation systems. Platelets are anucleate cells produced by megakaryocytes and are responsible for blood clotting and haemostasis (Lefrancais et al, 2017). They are also very abundant and play unexpected roles in immune responses (Maouia et al,…
KEGG T00046: PM0721
Entry PM0721 CDS T00046 Symbol ttrA Name (GenBank) TtrA KO K08357 tetrathionate reductase subunit A Organism pmu Pasteurella multocida subsp. multocida Pm70 Pathway pmu00920 Sulfur metabolism pmu01100 Metabolic pathways pmu01120 Microbial metabolism in diverse environments pmu02020 Two-component system Brite KEGG Orthology (KO) [BR:pmu00001] 09100 Metabolism 09102 Energy metabolism 00920 Sulfur metabolism PM0721 (ttrA) 09130 Environmental Information Processing 09132 Signal…
Herpes Zoster Pipeline Analysis Demonstrates Novel 18+
Herpes Zoster Pipeline DelveInsight’s, “Herpes Zoster Pipeline Insight 2023,” report provides comprehensive insights about 18+ companies and 20+ pipeline drugs in the Herpes Zoster pipeline landscape. It covers the Herpes Zoster pipeline drug profiles, including Herpes Zoster clinical trials and nonclinical stage products. It also covers the therapeutics assessment by…
KEGG module and abundance of its KEGG Orthologs for functioning
KEGG module and abundance of its KEGG Orthologs for functioning 0 Hi all, I’m trying to interpret KEGG Orholog (KO) abundance data from two different groups. As you know, KEGG module is composed of multiple KOs. Then, if I want to say “this KEGG module functions well and actively”, does…
A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei
Cell growth and transfections Procyclic form (PCF) T. brucei, strain 29-1354, which carries integrated genes for the T7 polymerase and the tetracycline repressor, was grown in SDM-79 medium supplemented with 10% fetal calf serum, in the presence of 50 μg/ml hygromycin. Cells were grown in the presence of 15 μg/ml G418 for…
[Kernel-packages] [Bug 2007050] Autopkgtest regression report (initramfs-tools/0.142ubuntu15.1)
All autopkgtests for the newly accepted initramfs-tools (0.142ubuntu15.1) for mantic have finished running. The following regressions have been reported in tests triggered by the package: initramfs-tools/0.142ubuntu15.1 (armhf) Please visit the excuses page listed below and investigate the failures, proceeding afterwards as per the StableReleaseUpdates policy regarding autopkgtest regressions [1]. people.canonical.com/~ubuntu-archive/proposed-…
KEGG T06063: 106511269
Entry 106522761 CDS T06063 Symbol pak1 Name (RefSeq) serine/threonine-protein kinase PAK 1 KO K04409 p21-activated kinase 1 [EC:2.7.11.1] Organism alim Austrofundulus limnaeus (annual killifish) Pathway alim04010 MAPK signaling pathway alim04012 ErbB signaling pathway alim04510 Focal adhesion alim04625 C-type lectin receptor signaling pathway alim04810 Regulation of actin cytoskeleton alim05132 Salmonella infection Brite KEGG Orthology…
GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21
Experimental model and subject details Mice Male ICR mice (Laboratory Animal Center of Zhejiang Academy of Medical Sciences) at age of 3 months (M), 9 M and 36 M, male C57BL/B6 wild‐type (WT) mice (Shanghai Slac Laboratory) at age of 3 M and 10 M, male GDF11-flox mice (GDF11f/f, mice carrying the “floxed” GDF11…
KEGG T00183: SAS2563
Entry SAS2563 CDS T00183 Name (GenBank) putative histidinol dehydrogenase KO K00013 histidinol dehydrogenase [EC:1.1.1.23] Organism sas Staphylococcus aureus subsp. aureus MSSA476 (MSSA) Pathway sas00340 Histidine metabolism sas01100 Metabolic pathways sas01110 Biosynthesis of secondary metabolites sas01230 Biosynthesis of amino acids Brite KEGG Orthology (KO) [BR:sas00001] 09100 Metabolism 09105 Amino acid metabolism 00340 Histidine metabolism SAS2563Enzymes [BR:sas01000] 1. Oxidoreductases 1.1 Acting on…
KEGG T00918: Mlut_12280
Entry Mlut_12280 CDS T00918 Name (GenBank) Undecaprenyl pyrophosphate synthetase KO K00806 undecaprenyl diphosphate synthase [EC:2.5.1.31] Organism mlu Micrococcus luteus Pathway mlu00550 Peptidoglycan biosynthesis mlu00900 Terpenoid backbone biosynthesis mlu01110 Biosynthesis of secondary metabolites Brite KEGG Orthology (KO) [BR:mlu00001] 09100 Metabolism 09107 Glycan biosynthesis and metabolism 00550 Peptidoglycan biosynthesis Mlut_12280 09109 Metabolism of terpenoids and polyketides 00900 Terpenoid backbone biosynthesis Mlut_12280 09180 Brite…
The analysis of the genotype of Sapovirus outbreaks in Zhejiang Province | Virology Journal
Leblanc D, Inglis GD, Boras VF, Brassard J, Houde A. The prevalence of enteric RNA viruses in stools from diarrheic and non-diarrheic people in southwestern Alberta, Canada. Arch Virol. 2017;162(1):117–28. Article CAS PubMed Google Scholar Becker-Dreps S, González F, Bucardo F. Sapovirus: an emerging cause of childhood diarrhea. Curr Opin…
KEGG T00139: BP3287
Entry BP3287 CDS T00139 Symbol atpG Name (GenBank) ATP synthase gamma chain KO K02115 F-type H+-transporting ATPase subunit gamma Organism bpe Bordetella pertussis Tohama I Pathway bpe00190 Oxidative phosphorylation bpe01100 Metabolic pathways Module bpe_M00157 F-type ATPase, prokaryotes and chloroplasts Brite KEGG Orthology (KO) [BR:bpe00001] 09100 Metabolism 09102 Energy metabolism 00190 Oxidative phosphorylation BP3287 (atpG) 09180 Brite Hierarchies 09181 Protein…
KEGG T01028: 706234
Entry 706234 CDS T01028 Symbol TRAP1 Name (RefSeq) heat shock protein 75 kDa, mitochondrial KO K09488 TNF receptor-associated protein 1 Organism mcc Macaca mulatta (rhesus monkey) Pathway mcc05012 Parkinson disease mcc05022 Pathways of neurodegeneration – multiple diseases Brite KEGG Orthology (KO) [BR:mcc00001] 09160 Human Diseases 09164 Neurodegenerative disease 05012 Parkinson disease 706234 (TRAP1) 05022 Pathways of neurodegeneration –…
KEGG T03271: 103675060
Entry 103675060 CDS T03271 Symbol APPL1 Name (RefSeq) DCC-interacting protein 13-alpha KO K08733 DCC-interacting protein 13 alpha Organism umr Ursus maritimus (polar bear) Pathway umr04211 Longevity regulating pathway umr05200 Pathways in cancer umr05210 Colorectal cancer Brite KEGG Orthology (KO) [BR:umr00001] 09150 Organismal Systems 09149 Aging 04211 Longevity regulating pathway 103675060 (APPL1) 09160 Human Diseases 09161 Cancer: overview 05200 Pathways in…
Inhibition of providencia vermicola FabD
Introduction Microbial resistance has become a problem in the contemporary medical environment due to the inadequate development of new antibiotics and the asinine prescription of antibiotics in both developed and developing nations. Antimicrobial resistance (AMR), which affects wealthy and developing nations, is a global concern.1 AMR is a problem for…
Loss of SETD2 aggravates colorectal cancer progression caused by SMAD4 deletion through the RAS/ERK signalling pathway
Backgound: Colorectal cancer (CRC) is a complex, multistep disease that arises from the interplay genetic mutations and epigenetic alterations. The histone H3K36 trimethyltransferase SET domain-containing 2 (SETD2), as an epigenetic signalling molecule, has a 5% mutation rate in CRC. SETD2 expression is decreased in the development of human CRC and…
transformers 4.35.1 – Download, Browsing & More
transformers 4.35.1 – Download, Browsing & More | Fossies Archive “Fossies” – the Fresh Open Source Software Archive Contents of transformers-4.35.1.tar.gz (14 Nov 15:37, 15700182 Bytes) About: Transformers supports Machine Learning for Pytorch, TensorFlow, and JAX by providing thousands of pretrained models to perform tasks on different modalities such as…
Potential Y-H? – LAMMPS General Discussion
Xtof November 14, 2023, 8:00am 1 Dear all, Would anyone know where to find the potential for Y-H? I found some potential for Y-Y in an article from 2013 but so far nothing about Y-H. Many thanks in advance and best regards,Christophe It’s good practice to reference the articles you…
KEGG T01001: 257194
Entry 257194 CDS T01001 Symbol NEGR1, DMML2433, IGLON4, KILON, Ntra Name (RefSeq) neuronal growth regulator 1 KO K06775 neuronal growth regulator 1 Organism hsa Homo sapiens (human) Pathway hsa04514 Cell adhesion molecules Brite KEGG Orthology (KO) [BR:hsa00001] 09130 Environmental Information Processing 09133 Signaling molecules and interaction 04514 Cell adhesion molecules 257194 (NEGR1) 09180 Brite Hierarchies 09183 Protein families: signaling…
Forecasting the dynamics of a complex microbial community using integrated meta-omics
Characterization of the microbial community From the experimental period between 21 March 2011 and 3 May 2012 (ref. 27), we previously obtained and analysed 51 weekly samples, to which we added 21 samples collected in the month of June during the years 2012–2016. The 72 samples were submitted to the…
KEGG T08541: 104528229
Entry 104528229 CDS T08541 Symbol SLC15A4 Name (RefSeq) solute carrier family 15 member 4 KO K14638 solute carrier family 15 (peptide/histidine transporter), member 3/4 Organism acar Antrostomus carolinensis (chuck-will’s-widow) Brite KEGG Orthology (KO) [BR:acar00001] 09180 Brite Hierarchies 09183 Protein families: signaling and cellular processes 02000 Transporters [BR:acar02000] 104528229 (SLC15A4)Transporters [BR:acar02000] Solute carrier family (SLC) SLC15: Proton oligopeptide cotransporter 104528229 (SLC15A4)…
KEGG T01011: 100038077
Entry 100038077 CDS T01011 Symbol nkx2-2 Name (RefSeq) homeobox protein Nkx-2.2 isoform X1 KO K08029 homeobox protein Nkx-2.2 Organism xtr Xenopus tropicalis (tropical clawed frog) Brite KEGG Orthology (KO) [BR:xtr00001] 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03000 Transcription factors [BR:xtr03000] 100038077 (nkx2-2)Transcription factors [BR:xtr03000] Eukaryotic type Helix-turn-helix Homeo domain ANTP: NKL 100038077 (nkx2-2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT…
KEGG T09424: 118385109
Entry 118385109 CDS T09424 Name (RefSeq) adenylosuccinate synthetase isozyme 2-like KO K01939 adenylosuccinate synthase [EC:6.3.4.4] Organism oke Oncorhynchus keta (chum salmon) Pathway oke00230 Purine metabolism oke00250 Alanine, aspartate and glutamate metabolism oke01100 Metabolic pathways oke01232 Nucleotide metabolism oke01240 Biosynthesis of cofactors Module oke_M00049 Adenine ribonucleotide biosynthesis, IMP => ADP,ATP Brite KEGG Orthology (KO)…
KEGG T08782: 127423656
Entry 127423656 CDS T08782 Name (RefSeq) heparan sulfate glucosamine 3-O-sulfotransferase 3B1-like KO K07809 [heparan sulfate]-glucosamine 3-sulfotransferase 3 [EC:2.8.2.30] Organism masi Myxocyprinus asiaticus (Chinese sucker) Pathway masi00534 Glycosaminoglycan biosynthesis – heparan sulfate / heparin Brite KEGG Orthology (KO) [BR:masi00001] 09100 Metabolism 09107 Glycan biosynthesis and metabolism 00534 Glycosaminoglycan biosynthesis – heparan sulfate / heparin 127423656 09180 Brite Hierarchies 09181 Protein…
The mystery of the ‘black box’ at the MacBook event. What is that object?
The mystery of the ‘black box’ at the MacBook event. What is that object? On October 30th, during the latter part of Apple’s new MacBook Pro unveiling event, a black machine box connected to the MacBook was briefly captured on camera. The presenter at the event was discussing the speed…
A genomic catalogue of soil microbiomes boosts mining of biodiversity and genetic resources
40,039 MAGs reconstructed from large-scale genome-resolved metagenomics To reconstruct previously unexplored bacterial and archaeal genomes, we performed a large-scale single-sample metagenomic assembly on 3304 soil metagenomes across the globe (Fig. 1a), including 363 metagenomes from the in-house dataset and 2941 from publicly available metagenomes. The soil samples were mainly collected from…
RNAseq from P4 murine whole kidneys with Polycystic Kidney Disease
Snap frozen Postnatal day4 murine kidney tissues were crushed using micropestles in RLT Buffer and RNA was extracted from these tissues using QiaShredders followed by Qiagen RNAeasy Mini Kits according to manufacturer’s protocol. RNA concentration and integrity were determined by Aligent bioanalyzer. cDNA library preparation was carried out using NEB…
KEGG T00186: ECA0055
Entry ECA0055 CDS T00186 Symbol prlC Name (GenBank) oligopeptidase A KO K01414 oligopeptidase A [EC:3.4.24.70] Organism eca Pectobacterium atrosepticum SCRI1043 Brite KEGG Orthology (KO) [BR:eca00001] 09180 Brite Hierarchies 09181 Protein families: metabolism 01002 Peptidases and inhibitors [BR:eca01002] ECA0055 (prlC)Enzymes [BR:eca01000] 3. Hydrolases 3.4 Acting on peptide bonds (peptidases) 3.4.24 Metalloendopeptidases 3.4.24.70 oligopeptidase A ECA0055 (prlC)Peptidases and inhibitors [BR:eca01002] Metallo peptidases Family M3 ECA0055 (prlC) BRITE hierarchy SSDB OrthologParalogGene…
KEGG T00644: APJL_0327
Entry APJL_0327 CDS T00644 Symbol rumA Name (GenBank) 23S rRNA (Uracil-5-)-methyltransferase KO K03215 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] Organism apj Actinobacillus pleuropneumoniae JL03 (serotype 3) Brite KEGG Orthology (KO) [BR:apj00001] 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03009 Ribosome biogenesis [BR:apj03009] APJL_0327 (rumA)Enzymes [BR:apj01000] 2. Transferases 2.1 Transferring one-carbon groups 2.1.1 Methyltransferases 2.1.1.190 23S rRNA (uracil1939-C5)-methyltransferase APJL_0327 (rumA)Ribosome biogenesis [BR:apj03009] Prokaryotic type rRNA modification factors 23S rRNA…
KEGG T00186: ECA2422
Entry ECA2422 CDS T00186 Symbol thrS Name (GenBank) threonyl-tRNA synthetase KO K01868 threonyl-tRNA synthetase [EC:6.1.1.3] Organism eca Pectobacterium atrosepticum SCRI1043 Pathway eca00970 Aminoacyl-tRNA biosynthesis Brite KEGG Orthology (KO) [BR:eca00001] 09120 Genetic Information Processing 09122 Translation 00970 Aminoacyl-tRNA biosynthesis ECA2422 (thrS) 09180 Brite Hierarchies 09181 Protein families: metabolism 01007 Amino acid related enzymes [BR:eca01007] ECA2422 (thrS) 09182 Protein families: genetic information processing 03016 Transfer…
Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens
Developing an epigenetic screening platform in human T cells Staphylococcus aureus Cas9 (SaCas9) has been extensively used for genome editing in vivo as its compact size (3,159 bp) relative to the conventional Streptococcus pyogenes Cas9 (SpCas9) enables packaging into adeno-associated virus26,27,28. However, SaCas9 has not been widely used for targeted gene…
KEGG T01028: 701915
Entry 701915 CDS T01028 Symbol KRT25 Name (RefSeq) keratin, type I cytoskeletal 25 KO K07604 type I keratin, acidic Organism mcc Macaca mulatta (rhesus monkey) Pathway mcc04915 Estrogen signaling pathway mcc05150 Staphylococcus aureus infection Brite KEGG Orthology (KO) [BR:mcc00001] 09150 Organismal Systems 09152 Endocrine system 04915 Estrogen signaling pathway 701915 (KRT25) 09160 Human Diseases 09171 Infectious disease: bacterial 05150 Staphylococcus…
KEGG T05390: C3V38_02785
Entry C3V38_14330 CDS T05390 Name (GenBank) GTP pyrophosphokinase KO K01139 GTP diphosphokinase / guanosine-3′,5′-bis(diphosphate) 3′-diphosphatase [EC:2.7.6.5 3.1.7.2] Organism dit Dietzia sp. oral taxon 368 Pathway dit00230 Purine metabolism dit01100 Metabolic pathways Brite KEGG Orthology (KO) [BR:dit00001] 09100 Metabolism 09104 Nucleotide metabolism 00230 Purine metabolism C3V38_14330 09180 Brite Hierarchies 09182 Protein families: genetic information processing 03009 Ribosome biogenesis [BR:dit03009] C3V38_14330Enzymes [BR:dit01000] 2. Transferases 2.7 Transferring…
KEGG T01028: 698365
Entry 698365 CDS T01028 Symbol AMACR Name (RefSeq) alpha-methylacyl-CoA racemase KO K01796 alpha-methylacyl-CoA racemase [EC:5.1.99.4] Organism mcc Macaca mulatta (rhesus monkey) Pathway mcc00120 Primary bile acid biosynthesis mcc01100 Metabolic pathways mcc04146 Peroxisome Module mcc_M00104 Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate Brite KEGG Orthology (KO) [BR:mcc00001] 09100 Metabolism 09103 Lipid metabolism 00120 Primary bile acid biosynthesis 698365 (AMACR) 09140…
KEGG T01028: 703937
Entry 703937 CDS T01028 Symbol PTPRG Name (RefSeq) receptor-type tyrosine-protein phosphatase gamma isoform X2 KO K16667 receptor-type tyrosine-protein phosphatase gamma [EC:3.1.3.48] Organism mcc Macaca mulatta (rhesus monkey) Brite KEGG Orthology (KO) [BR:mcc00001] 09180 Brite Hierarchies 09181 Protein families: metabolism 01009 Protein phosphatases and associated proteins [BR:mcc01009] 703937 (PTPRG)Enzymes [BR:mcc01000] 3. Hydrolases 3.1 Acting on ester bonds 3.1.3 Phosphoric-monoester hydrolases 3.1.3.48 protein-tyrosine-phosphatase 703937 (PTPRG)Protein phosphatases and…
FAT10 is phosphorylated by IKK{beta} to inhibit the antiviral type-I interferon response
Introduction The innate immune system represents the host´s first-line defense against viral infections (Koyama et al, 2008). In this context, IFN-I are produced by all nucleated cells and represent the principal cytokines that counteract viral replication (Ivashkiv & Donlin, 2014). In fact, several receptors of the infected cell can recognize…
KEGG T07278: 119316072
Entry 119322531 CDS T07278 Name (RefSeq) porphobilinogen deaminase, chloroplastic-like KO K01749 hydroxymethylbilane synthase [EC:2.5.1.61] Organism tdc Triticum dicoccoides (wild emmer wheat) Pathway tdc00860 Porphyrin metabolism tdc01100 Metabolic pathways tdc01110 Biosynthesis of secondary metabolites tdc01240 Biosynthesis of cofactors Module tdc_M00121 Heme biosynthesis, plants and bacteria, glutamate => heme Brite KEGG Orthology (KO) [BR:tdc00001] 09100 Metabolism 09108…
KEGG T01028: 704242
Entry 704242 CDS T01028 Symbol CYP39A1 Name (RefSeq) 24-hydroxycholesterol 7-alpha-hydroxylase KO K07439 24-hydroxycholesterol 7alpha-hydroxylase [EC:1.14.14.26] Organism mcc Macaca mulatta (rhesus monkey) Pathway mcc00120 Primary bile acid biosynthesis Brite KEGG Orthology (KO) [BR:mcc00001] 09100 Metabolism 09103 Lipid metabolism 00120 Primary bile acid biosynthesis 704242 (CYP39A1) 09180 Brite Hierarchies 09181 Protein families: metabolism 00199 Cytochrome P450 [BR:mcc00199] 704242 (CYP39A1)Enzymes [BR:mcc01000] 1. Oxidoreductases 1.14 Acting on paired…
KEGG T01028: 694719
Entry 694719 CDS T01028 Symbol RPL23 Name (RefSeq) 60S ribosomal protein L23 KO K02894 large subunit ribosomal protein L23e Organism mcc Macaca mulatta (rhesus monkey) Pathway mcc03010 Ribosome mcc05171 Coronavirus disease – COVID-19 Brite KEGG Orthology (KO) [BR:mcc00001] 09120 Genetic Information Processing 09122 Translation 03010 Ribosome 694719 (RPL23) 09160 Human Diseases 09172 Infectious disease: viral 05171 Coronavirus disease – COVID-19 694719…
KEGG T08540: 104459063
Entry 104463828 CDS T08540 Symbol ACOX3 Name (RefSeq) peroxisomal acyl-coenzyme A oxidase 3 KO K00232 acyl-CoA oxidase [EC:1.3.3.6] Organism pguu Pterocles gutturalis (yellow-throated sandgrouse) Pathway pguu00071 Fatty acid degradation pguu00410 beta-Alanine metabolism pguu00592 alpha-Linolenic acid metabolism pguu00640 Propanoate metabolism pguu01040 Biosynthesis of unsaturated fatty acids pguu01100 Metabolic pathways pguu01200 Carbon metabolism pguu01212 Fatty…
An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission
Mice and Golden Syrian hamsters All research experiments in this study comply with all relevant ethical regulations. The Institutional Animal Care and Use Committee approved the animal protocol at the University of Maryland (#R-APR-20-18 and #R-MAR-21-19). The animals were acclimatized at the animal facility for 4–6 days before initiating experiments….
KEGG T01028: 704366
Entry 704366 CDS T01028 Symbol ZDHHC15 Name (RefSeq) palmitoyltransferase ZDHHC15 KO K20028 palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225] Organism mcc Macaca mulatta (rhesus monkey) Brite KEGG Orthology (KO) [BR:mcc00001] 09180 Brite Hierarchies 09182 Protein families: genetic information processing 04131 Membrane trafficking [BR:mcc04131] 704366 (ZDHHC15)Enzymes [BR:mcc01000] 2. Transferases 2.3 Acyltransferases 2.3.1 Transferring groups other than aminoacyl groups 2.3.1.225 protein S-acyltransferase 704366 (ZDHHC15)Membrane trafficking [BR:mcc04131] SNARE SNARE associated proteins Palmitoyltransferases 704366 (ZDHHC15) BRITE hierarchy…
KEGG T05489: A6B45_00495
Entry A6B45_05465 CDS T05489 Name (GenBank) diacetyl reductase KO K03366 meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304] Organism lsu Leuconostoc suionicum Pathway lsu00650 Butanoate metabolism lsu01110 Biosynthesis of secondary metabolites Brite KEGG Orthology (KO) [BR:lsu00001] 09100 Metabolism 09101 Carbohydrate metabolism 00650 Butanoate metabolism A6B45_05465Enzymes [BR:lsu01000] 1. Oxidoreductases 1.1 Acting on the CH-OH group of donors 1.1.1 With NAD+…
KEGG T01028: 695442
Entry 695442 CDS T01028 Symbol RPLP1 Name (RefSeq) 60S acidic ribosomal protein P1 KO K02942 large subunit ribosomal protein LP1 Organism mcc Macaca mulatta (rhesus monkey) Pathway mcc03010 Ribosome mcc05171 Coronavirus disease – COVID-19 Brite KEGG Orthology (KO) [BR:mcc00001] 09120 Genetic Information Processing 09122 Translation 03010 Ribosome 695442 (RPLP1) 09160 Human Diseases 09172 Infectious disease: viral 05171 Coronavirus disease –…
KEGG T01028: 717682
Entry 717682 CDS T01028 Symbol SEPTIN2 Name (RefSeq) septin-2 isoform X1 KO K16942 septin 2 Organism mcc Macaca mulatta (rhesus monkey) Pathway mcc05100 Bacterial invasion of epithelial cells Brite KEGG Orthology (KO) [BR:mcc00001] 09160 Human Diseases 09171 Infectious disease: bacterial 05100 Bacterial invasion of epithelial cells 717682 (SEPTIN2) 09180 Brite Hierarchies 09182 Protein families: genetic information processing 04131 Membrane trafficking…
Molecular diagnosis, phylogenetic analysis, and antifungal susceptibility profiles of Candida species isolated from neutropenic oncological patients | BMC Infectious Diseases
Eissa S, Khedr R, Romeih M, Halaby L, Elanany M, Madney Y. Clinical characteristics and outcome of invasive fungal sinusitis in children with hematological malignancies. Med Mycol. 2022;60(4):myac010. Article PubMed Google Scholar Lin G-L, Chang H-H, Lu C-Y, Chen C-M, Lu M-Y, Lee P-I, Jou S-T, Yang Y-L, Huang L-M,…
systemtap: autopkgtest regression: Pass 4: compilation failed. [man error::pass4]
Source: systemtap Version: 4.9-1 Severity: serious User: debi…@lists.debian.org Usertags: regression Dear maintainer(s), Your package has an autopkgtest, great. However, it fails since a couple of months. Can you please investigate the situation and fix it? I copied some of the output at the bottom of this report. The release team…
KEGG T01028: 699325
Entry 699325 CDS T01028 Symbol OSBP Name (RefSeq) oxysterol-binding protein 1 KO K20456 oxysterol-binding protein 1 Organism mcc Macaca mulatta (rhesus monkey) Brite KEGG Orthology (KO) [BR:mcc00001] 09180 Brite Hierarchies 09182 Protein families: genetic information processing 04131 Membrane trafficking [BR:mcc04131] 699325 (OSBP)Membrane trafficking [BR:mcc04131] Endoplasmic reticulum (ER) – Golgi transport Others Oxysterol-binding proteins 699325 (OSBP) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif…
KEGG T04128: 106346836
Entry 111199314 CDS T04128 Name (RefSeq) GDP-L-fucose synthase 1 isoform X2 KO K02377 GDP-L-fucose synthase [EC:1.1.1.271] Organism bna Brassica napus (rape) Pathway bna00051 Fructose and mannose metabolism bna00520 Amino sugar and nucleotide sugar metabolism bna01100 Metabolic pathways bna01250 Biosynthesis of nucleotide sugars Brite KEGG Orthology (KO) [BR:bna00001] 09100 Metabolism 09101 Carbohydrate metabolism 00051 Fructose and mannose…