Tag: KRAS

A study out of Austria suggests gene changes in those with biliary tract cancer offers new avenues for new precision oncology therapies. Gene alterations in biliary tract cancer offer potential targets for current or future precision therapies. This is demonstrated by a highly acclaimed study conducted by Karl Landsteiner University…

CMI Next-Gen DNA Sequencing Solutions: Empowering Precision Medicine & Genetic Research for Advancements in Healthcare & Biotechnology Burlingame, June 07, 2023 (GLOBE NEWSWIRE) — According to Coherent Market Insights, Global DNA Sequencing Market is estimated to be valued at US$ 6,802.2 million in 2023 and is expected to exhibit a CAGR…

Burlingame, June 07, 2023 (GLOBE NEWSWIRE) — According to Coherent Market Insights, Global DNA Sequencing Market is estimated to be valued at US$ 6,802.2 million in 2023 and is expected to exhibit a CAGR of 11.7% during the forecast period (2023-2030). Analysts’ Views on Global DNA Sequencing Market: Rising demand for…

Cold Spring Harb Mol Case Stud. 2023 Apr; 9(2): a006256. ,1,2 ,1,2 ,1,2 ,2,3 ,4 and 1,2 Mahvish Q. Rahim 1Pediatric Hematology Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA; 2Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, USA; April Rahrig 1Pediatric Hematology Oncology,…

The Human Gene Mutation Test Kit Market, where demand is steadily increasing due to improved purchasing power, is expected to be beneficial for the global market. This comprehensive research report is an exhaustive compilation of market developments and growth factors optimizing their future growth trajectories from accurate data on the…

Amgen has shared positive results from a late-stage study evaluating its KRAS inhibitor, Lumakras (sotorasib), in certain lung cancer patients. The phase 3 CodeBreaK 200 trial compared Lumakras to docetaxel chemotherapy in patients with previously treated, locally advanced and unresectable or metastatic KRAS G12C-mutated non-small cell lung cancer (NSCLC). New data…

Midha, S., Chawla, S. & Garg, P. K. Modifiable and non-modifiable risk factors for pancreatic cancer: A review. Cancer Lett. 381(1), 269–277 (2016). Article  CAS  PubMed  Google Scholar  Huang, S. et al. Interferon alpha-inducible protein 27 (IFI27) is a prognostic marker for pancreatic cancer based on comprehensive bioinformatics analysis. Bioengineered…

Summary CRISPR systems are prokaryotic adaptive immune systems that use RNA-guided Cas nucleases to recognize and destroy foreign genetic elements. To overcome CRISPR immunity, bacteriophages have evolved diverse families of anti-CRISPR proteins (Acrs). Recently, Lin et al. (2020) described the discovery and characterization of 7 Acr families (AcrVIA1–7) that inhibit…

mutational signatures in different tumor samples 0 Dear all. I am currently researching the mutational signatures (or patterns?) in a large cohort of targeted sequencing of tumor samples. I found that the definition of “mutational signatures” in COSMIC is like this : “The profile of each signature is displayed using…

KRAS mutations are among the most frequent gain-of-function alterations found in patients with cancer and their therapeutic targeting has long been a key objective in precision oncology8,9,10,11,12. The KRAS GTPase cycles between an active (GTP-bound) and an inactive (GDP-bound) state. GTP hydrolysis is enhanced by GTPase-activating proteins13, whereas GDP to…

—Newly appointed members Tara Arvedson, Ph.D., and Janine Schuurman, Ph.D., to support Cartography in the advancement of first-in-class precision cancer immunotherapies— SOUTH SAN FRANCISCO, May 31, 2023–(BUSINESS WIRE)–Cartography Biosciences, an immuno-oncology company creating biologic therapies against novel targets guided by the first-ever comprehensive antigen atlas, today announced the appointments of…

How extract specific SNP position from the bed file-Bedtools 1 I have one bed file with start and end coordinate (range in bed format). I need to extract a specific position from this range bed (for example I need to extract “chr12 25392999” position from the below bed file). How…

Agnes Stephanie Harahap,1– 3 Imam Subekti,4 Sonar Soni Panigoro,5 Asmarinah,6 Lisnawati,1 Retno Asti Werdhani,7 Hasrayati Agustina,8 Dina Khoirunnisa,1 Mutiah Mutmainnah,1 Salinah,1 Alvita Dewi Siswoyo,9 Maria Francisca Ham1,2 1Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; 2Human Cancer Research Center-Indonesian Medical Education and Research Institute,…

Huang, H., Weng, H. & Chen, J. m6A modification in coding and non-coding RNAs: roles and therapeutic implications in cancer. Cancer Cell 37, 270–288 (2020). Article  CAS  PubMed  PubMed Central  Google Scholar  Qing, Y., Su, R. & Chen, J. RNA modifications in hematopoietic malignancies: a new research frontier. Blood 138,…

MIT researchers have developed a fast and precise technique using CRISPR genome-editing technology to engineer specific cancer-related mutations in mouse models, a step that could significantly advance drug development and understanding of tumor development. p53 (blue) binds to DNA (pink) to help prevent cancer formation. With the new method, scientists…

Golubnitschaja O, Baban B, Boniolo G, Wang W, Bubnov R, Kapalla M, et al. Medicine in the early twenty-first century: paradigm and anticipation – EPMA position paper 2016. EPMA J. 2016;7:23. Article  PubMed  PubMed Central  Google Scholar  Kropp M, Golubnitschaja O, Mazurakova A, Koklesova L, Sargheini N, Vo T-TKS, et…

Introduction Liver cancer is the third most common cause of cancer death globally with hepatocellular carcinoma (HCC) accounting for the majority of liver cancer.1,2 Early HCC (stage I/II) treatment mainly includes radical surgical resection, radiofrequency ablation and liver transplantation.3,4 However, there is a lack of typical clinical symptoms with early-stage…

Oslo – Circio Holding ASA (formerly Targovax ASA) (OSE: TRVX) Circio’s management and Board of Directors today held a live webcast. In the webcast, CEO Erik D. Wiklund provided a brief company presentation, together with an update on the circRNA-platform, followed by a Q&A session with representatives from the Compensation…

Best known for its folklore and tales of the Vikings, Norway’s landscape boasts postcard-like islands and the northern lights. In addition to ranking top as one of the happiest nations in the world, the country relies on sectors like oil and gas, hydropower and aquaculture to strengthen its economic growth….

Oslo, Norway, 16 May 2023 – Circio Holding ASA (formerly Targovax ASA*) (OSE: TRVX) Circio’s management and Board of Directors today held a live webcast. In the webcast, CEO Erik D. Wiklund provided a brief company presentation, together with an update on the circRNA-platform, followed by a Q&A session with…

Current CRISPR-Cas9 models can expand this proportion but are limited by error-prone DNA repair, whereas genetically modified mice models only capture a small portion of the genetic defects that cause human cancer. Thousands of mutations associated with tumor formation have been discovered in cancer patients’ genomes. However, for the great…

Maya Khalil, MD, assistant professor of medicine, Division of Hematology and Oncology, the University of Alabama at Birmingham (UAB), oncologist, O’Neal Comprehensive Cancer Center, UAB Medicine, discusses the use of first-line durvalumab (Imfinzi) plus tremelimumab (Imjudo) in patients with non–small cell lung cancer (NSCLC) enrolled in the phase 3 POSEIDON trial…

Oslo, Norway, 12 May 2023 – Circio Holding ASA (formerly Targovax ASA*) (OSE: TRVX): Circio’s management and Board of Directors invite to a live webcast on Tuesday 16 May at 10am CEST. In the webcast, CEO Erik D. Wiklund will provide a brief company update, followed by a Q&A session…

Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development, but researchers are unsure how the vast majority of these mutations contribute to cancer because there’s no easy way to study them in animal models. Massachusetts Institute of Technology researchers have now developed a way to…

A new technique for introducing cancer-associated mutations into mouse models is reported in Nature Biotechnology this week. Genetically engineered mouse models have become an invaluable tool for examining the mechanisms by which cancer drivers promote tumor development and progression in vivo, but generating and maintaining these models is expensive and…

Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development. However, for the vast majority of those mutations, researchers are unsure of how they contribute to cancer because there’s no easy way to study them in animal models. In an advance that could help scientists make…

Oslo – Circio Holding ASA (formerly Targovax ASA) (OSE: TRVX) today announces that an abstract describing its circular RNA platform has been accepted for poster presentation at the 2023 American Society of Gene + Cell Therapy (ASGCT) Annual Meeting in Los Angeles, USA. The abstract describes the development of Circio’s…

Oslo, Norway, 3 May 2023 – Circio Holding ASA (formerly Targovax ASA*) (OSE: TRVX) today announces that an abstract describing its circular RNA platform has been accepted for poster presentation at the 2023 American Society of Gene + Cell Therapy (ASGCT) Annual Meeting in Los Angeles, USA. The abstract describes…

Reported initial positive clinical data from first two cohorts of Phase II of ongoing Phase I/II study (COVALENT-111) of BMF-219, Biomea’s lead investigational, orally administered covalent menin inhibitor, as a novel, potentially disease-modifying treatment for patients with type 2 diabetes Continued enrolling four liquid tumor cohorts in ongoing Phase I…

Life science has a habit of overturning long-standing ideas about the causes of human disease. Xin Lu, a cancer biologist at University of Notre Dame, came to that realization a few years ago when a family of five visited his institution to learn more about their condition. The father had…

The FDA has approved xT CDx, a 648-gene next-generation sequencing (NGS) assay for solid tumor profiling, and companion diagnostic for patients with colorectal cancer.1 The qualitative NGS-based in vitro diagnostic device is intended to be leveraged to identify substitutions like single nucleotide variants and multinucleotide variants and insertion and deletion…

Clinical and biochemical characteristics of parathyroid carcinoma In total, 50 thyroid tissues were collected from three groups, 12 parathyroid carcinomas, 28 parathyroid adenomas, and 10 normal parathyroid tissues, for genomic and transcriptomic profiling (Fig. 1). The detailed protocols and quality control procedures are described in the Materials and Methods section….

Michael Andreeff, MD, PhD The E-selectin inhibitor uproleselan (GMI-1271) has shown preliminary efficacy in patients with acute myeloid leukemia (AML), and E-selectin could represent one of several novel targets for treatment of this patient population, according to Michael Andreeff, MD, PhD. Previously, a phase 1/2 trial (NCT02306291) investigating uproleselan plus…

Michael Shusterman, MD, clinical assistant professor, Department of Medicine, NYU Long Island School of Medicine, discusses findings from a retrospective study to determine the feasibility of a novel genome-wide methylome enrichment platform for the early detection of multiple solid tumors. This study included samples of cell-free DNA extracted from the…

Norwegian biotech Targovax recently said it’s planning to rebrand as Circio, marking its shift from clinical stage immuno-oncology company to one focused on circular RNA (circRNA) therapeutics. The name change is subject to approval by Targovax’s shareholders, who are set to vote at the company’s annual general meeting on May…

Bergqvist, C. et al. Neurofibromatosis 1 French national guidelines based on an extensive literature review since 1966. Orphanet J. Rare Dis. 15, 1–23 (2020). Article  Google Scholar  Martin, G. A. et al. The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21. Cell 63, 843–849 (1990)….

Multi-omics analyses of the ICC samples Following multiregional sampling of primary ICC cases, we performed multi-omics analyses, including genome, transcriptome, proteome, and metabolome analysis. We used 10 (67 samples), 11 (88 samples), 10 (49 samples) and 10 (49 samples) ICC cases for WES, whole-transcriptome sequencing, proteomic analysis, and metabolomic analysis,…

· The name Circio encapsulates the strategic shift to focus on the innovative, proprietary circular RNA (circRNA) platform · circRNA has the potential to outperform mRNA, and Circio’s pipeline is initially targeting cancer, with plans to rapidly expand into vaccines and gene therapy · International patent applications covering Circio’s vector…

Case Reports . 2023 Apr 12;11(4):e7156. doi: 10.1002/ccr3.7156. eCollection 2023 Apr. Affiliations Expand Affiliations 1 Department of Pathology University of California San Francisco USA. 2 Helen Diller Family Comprehensive Cancer Center University of California San Francisco USA. Item in Clipboard Case Reports Alexander Craig et al. Clin Case Rep. 2023. Show…

Lisa Ximena Rodriguez-Rojas,1,2 Estephania Candelo,3,4 Harry Pachajoa,1,2,4 Juan Esteban Garcia-Robledo,3 Jose Antonio Nastasi-Catanese,1,2 Jorge Andres Olave-Rodriguez,2 Angela R Zambrano5 1Department of Human Genetics, Fundación Valle del Lili, Cali, Colombia; 2Faculty of Health Sciences, Universidad Icesi, Cali, Colombia; 3Fundación Valle del Lili, Centro de Investigaciones Clínicas, Cali, Colombia; 4Centro de Investigaciones…

DiaCarta, Ltd. Abstracts demonstrating XNA technology’s improvements to assay sensitivity across different technology platforms and support for use in companion diagnostics (CDx) assay development Additional abstracts to further support XNA technology’s potential for use in minimal residual disease (MRD) monitoring of residual cancer cells PLEASANTON, Calif., April 16, 2023 (GLOBE…

Genomic profiling of circulating tumor DNA (ctDNA) with a large panel appeared feasible in a routine setting and helped to obtain relevant molecular information that could inform strategies with targeted therapies for patients with metastatic solid tumors, according to findings from the prospective PRISM study published in Annals of Oncology….

Sponsored Content by MaxCyte, Inc.Apr 13 2023Reviewed by Maria Osipova NK cells have a crucial role in cancer surveillance and offer a potential avenue for adoptive cell transfer as either mono- or combination immunotherapy. Previous investigations into transferring unmodified NK cells have demonstrated their clinical safety and limited anti-tumor effectiveness.1,2 NK…

NEW YORK – New research suggests extrachromosomal DNA (ecDNA) containing amplified oncogenes may be present not only in some esophageal cancers but also in individuals with Barrett’s esophagus, a condition that can progress to esophageal cancer in a small subset of affected individuals. “These findings have profound implications for our…

COLUMBUS, Ohio – New smart-drug treatment options for pancreatic cancer, immuno-oncology treatments and real-time immune-monitoring strategies are among the research topics to be presented by investigators at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) at…

RAHWAY – Merck (NYSE: MRK), known as MSD outside of the United States and Canada, and Eisai today provided updates on two Phase 3 trials, LEAP-003 and LEAP-017 investigating KEYTRUDA, Merck‘s anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai. LEAP-003: Merck and Eisai…

1. Introduction Lung cancer is the second most frequent cancer and the leading cause of cancer death in 2020, representing approximately 1 in 10 (11.4%) cancers diagnosed and 1 in 5 (18.0%) deaths [1]. In Lithuania, with a population of 2.7 million, a rough number of 1500 new cases of…

Background: To unravel how the integrity of nuclear and mitochondrial circulating cell-free DNA (cfDNA) contributes to its plasma quantity in colorectal cancer (CRC) patients. Methods: CfDNA from plasma samples of 80 CRC patients stratified by tumour stage and 50 healthy individuals were extracted. Total cfDNA concentration was determined and equal…

A large number of studies have shown that higher total cfDNA levels can be detected in the plasma of colorectal cancer patients, although, especially in late tumour stages [11, 12, 35, 36]. To date, it remains unclear how the lengths of nuclear and mitochondrial cfDNA fragments contribute to total cfDNA…

A kind of immunotherapy, cancer vaccines have been around since the link between human papillomavirus (HPV) and cancer was discovered in the 1980s. For the prevention of cancers – cervical, vaginal, vulvar and anal cancers – caused by the virus, vaccines were developed, and later approved by the Food and…

FG spectrum in pediatric AML patients A combinatorial approach, including conventional and next-generation sequencing (NGS)-based assays, was employed to profile the FG landscape (see Methods). FG analysis was feasible for 138 patients (94% of the entire cohort, Supplementary Data 1) from whom suitable testing materials were available. The most common FGs…

Certis Oncology Solutions (“Certis”), a precision oncology and translational science company focused on combining functional assays and artificial intelligence to advance personalized medicine, today announced that three abstracts have been accepted for presentation at the upcoming American Association for Cancer Research (AACR) Annual Meeting, to be held in Orlando, Fla….

Goddard, E. T., Bozic, I., Riddell, S. R. & Ghajar, C. M. Dormant tumour cells, their niches and the influence of immunity. Nat. Cell Biol. 20, 1240–1249 (2018). Article  CAS  PubMed  Google Scholar  Malladi, S. et al. Metastatic latency and immune evasion through autocrine inhibition of WNT. Cell 165, 45–60…

NEW YORK – Researchers from the Novartis Institutes for BioMedical Research (NIBR) have developed a method to determine clonal hematopoiesis in cancer patients from cell-free DNA (cfDNA) alone, using a computational model that can discriminate between blood-derived mutations arising from clonal hematopoiesis of indeterminate potential (CHIP) and tumor-derived mutations. CfDNA sequencing is gaining…

Expanded clinical development footprint of BMF-219, the company’s lead investigational, orally administered, covalent menin inhibitor, to eight liquid and solid tumor indications and type 2 diabetes across three ongoing clinical trials COVALENT-101 (Phase I study) enrolling four liquid tumor cohorts, each focused on distinct patient subsets of acute lymphocytic and…

Mice Rosa26-YFP48, Rosa-tDTomato49, K14creER, Lgr5creER (ref. 50), KrasLSLG12D (ref. 51) and Trp53fl/fl (ref. 52) mice were obtained from the NCI mouse repository and Jackson Laboratories. Rhojfl/fl mice53 were a gift from A. Uemura. All mice used in this study were composed of males and females with mixed genetic background. Mouse…

Background: Exosomal circRNAs played critical roles in tumor development and progression and might be novel biomarkers in the diagnosis and treatment of various cancers. However, the biological functions and clinical implications of exosomal circRNAs in breast cancer are unclear. Methods: Expression profiles of exosomal circRNAs in exoRBase 2.0 database were…

1. Introduction Neuroendocrine tumors (NETs) are a heterogeneous group of tumors originating from neuroendocrine cells and harbor malignant potential [1,2]. The incidence of NETs is becoming more common worldwide, and their characteristics and behavior can vary widely [1,2]. The incidence of gastrointestinal NETs depends on the primary tumor site, with…

March 22, 2023 10 min read Source/Disclosures Published by: Disclosures: Disis reports being a stockholder/founder of EpiThany; grants from Aston Sci. and Bavarian Nordic during the conduct of the breast cancer vaccine study; serving as editor of JAMA Oncology outside the submitted work; and royalties for a…

Company Logo Dublin, March 20, 2023 (GLOBE NEWSWIRE) — The “Next Generation Sequencing Market Size (Value, Volume, ASP) by Segments, Share, Trend and SWOT Analysis, Regulatory and Reimbursement Landscape, Procedures and Forecast, 2015-2033” report has been added to ResearchAndMarkets.com‘s offering. NGS allows an entire genome to be sequenced at once…

Background: Pancreatic adenocarcinoma is one of the cancers with the worst prognosis. The current treatment paradigm based on combination chemotherapy has improved survival over the last decade, but the disease is still fatal in most cases. New therapies exploiting the increasing understanding of the molecular pathology of the disease are…

Introduction Colorectal cancer (CRC) is a leading cause of cancer-related death1 and its mortality rate is expected to rise worldwide, due to population growth and aging, thus entailing a global public health challenge. CRC mortality is mainly due to therapy resistance and metastasis, which are driven by a small population…

Oslo, Norway, 15 March 2023 – Targovax ASA (OSE: TRVX) today announces that an abstract describing its circular RNA platform has been accepted for poster presentation at the 2023 American Association for Cancer Research (AACR) Annual Meeting in Orlando, USA. The abstract describes the advantage of protein expression utilizing Targovax´proprietary…

Introduction In recent years, CIN has gained great importance due to its implications for both, the diagnosis and prognosis of cancer. Recent studies have suggested that both CIN and clonal heterogeneity, influence cancer progression, aggressiveness, prognosis, and response to therapy.1–4 The above because both, CIN and clonal heterogeneity, lead to…

· Targovax has an early-mover advantage in circRNA, a novel area of RNA therapeutics attracting substantial interest from pharma and investors internationally · Targovax remains confident in the significant potential of ONCOS-102, but due to the currently challenging market conditions phase 2 development will only proceed once a partnership or…

Image: DNA sequencing autoradiograph – coloured. Credits: Michele Studer. Attribution 4.0 International (CC BY 4.0) A gene test already used routinely in the NHS can guide use of chemotherapy in people with bowel cancer by predicting whether or not they will benefit. The test could allow doctors to select patients whose…

NEW YORK – Researchers at Children’s Hospital Los Angeles (CHLA) have developed a liquid biopsy assay that uses low-pass whole-genome sequencing assay to help diagnose or provide prognostic information for pediatric solid tumors. The researchers detailed their development and validation of the assay in a paper published this month in…

ANKLE1 is the causal gene for breast and ovarian cancer risk in the chr19p13.1 region Expression quantitative trait loci (eQTL) data have revolutionized how geneticists identify candidate causal genes from genome-wide association study (GWAS) loci. We integrated the most recent meta-analysis of breast cancer GWAS10 and Genotype-Tissue Expression (GTEx) project…

1 Introduction Cancer is one of the world’s most serious threats to human health, with high morbidity and mortality rates, and according to the latest global data, 9.96 million patients will die from cancer in 2020 (1). Cancer is a genetic abnormal disease triggered by a long-term combination of multiple…

Cell lines Immortalised HA1E (hTERT and SV40ER) and tumourigenic HA1ER cells (hTERT, SV40ER and HRAS-G12V) from stepwise tumourigenesis models generated from normal human embryonic kidney cells were obtained from Dr. Hahn (Broad Institute of MIT and Harvard, Cambridge, USA). Cells were cultured in DMEM (1 g/L glucose) (Gibco, cat. #10567014) supplemented…

domoyega/E+ via Getty Images Investment Overview – Cash Intensive But Cash Rich – At Current Price Relay Offers The Patient Investor Value I have covered Relay Therapeutics (NASDAQ:RLAY) several times for Seeking Alpha since the company completed what was, at the time, the third largest biotech IPO in history, raising…

Front Genet. 2022; 13: 964840. , 1 , 1 , 1 , 2 , 2 , 2 , 2 , 2 , 3 ,* and 4 ,* Yun Zhu 1 Department of Dermatology, The People’s Hospital of Yuxi City, Yuxi, China Weimin Yan 1 Department of Dermatology, The People’s Hospital…

Oslo – Targovax ASA (OSE: TRVX), a clinical stage biotechnology company developing immune activators to target hard-to-treat solid tumors, today announces its fourth quarter 2022 results. Members of Targovax’s executive management team will give an online presentation to investors, analysts and the press at 10:00 CET today. FOURTH QUARTER 2022…

Gene-targeted therapy and immunotherapy can be regarded as the most cutting-edge methods in current cancer treatment, saving the lives of many cancer patients. An essential indicator in these new types of cancer treatment is cancer biomarker testing. Here are answers to nine frequently asked questions about cancer markers. 1. What…

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Jacob Sands, MD: Hello. I’m Dr Jacob Sands, thoracic medical oncologist at the Dana-Farber Cancer Institute. Welcome to season 2 of Medscape’s…

· The financing will support initiation of the ONCOS-102 melanoma phase 2 and TG01 mutant RAS clinical trials and in vivo PoC studies for the ground-breaking circRNA program · The convertible bond facility with London-based Atlas Capital Markets provides a secured and flexible source of capital to advance all of…

Hexagon’s interdisciplinary platform enables broad opportunities across multiple therapeutic areas; company initially focused on oncology and infectious diseases Tara Arvedson, Ph.D., former Executive Director of Oncology Research at Amgen, who joined Hexagon last year as SVP, Research, has been promoted to Chief Scientific Officer Victor Cee, Ph.D., former research project…

The following is a summary of “Circulating Tumor DNA Identifies Diverse Landscape of Acquired Resistance to Anti–Epidermal Growth Factor Receptor Therapy in Metastatic Colorectal Cancer,” published in the January 20, 2023 issue of Oncology by Topham, et al. Anti-epidermal growth factor receptor (EGFR) antibodies are potent therapies for metastatic colorectal…

What do oncogenes regulate? Immunopeptidomics keeps teaching us. Read about articles on these topics recently published in Molecular & Cellular Proteomics.   What do oncogenes regulate? Oncogenes are genes that have the potential to cause cancer. Depending on the oncogenes’  functional role, their mutations, overexpression or downregulation drive various forms…

Background Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive subtype of non-Hodgkin lymphoma and the Epstein–Barr virus (EBV), which is believed to play an important role in lymphomagenesis (1), is usually detected in malignant cells. Despite an improvement in treatment strategies including non-anthracycline-based chemotherapy, the disease recurs or progresses in…

Clinicopathological characteristics The clinicopathological features of the 56 stage IV GC patients are shown in Table 1. There were 29 males and 27 females. The mean age was 65.8 years old. The tumor was located mostly in the middle third of the stomach. Approximately 69.6% of the 56 patients had…

Background. Oxidative stress (OS) can either lead to leukemogenesis or induce tumor cell death by inflammation and immune response accompanying the process of OS through chemotherapy. However, previous studies mainly focus on the level of OS state and the salient factors leading to tumorigenesis and progression of acute myeloid leukemia…

  Abacavir Infectious Diseases HLA-B Boxed Warning, Dosage and Administration, Contraindications, Warnings and Precautions   Abemaciclib (1) Oncology ESR(Hormone Receptor) Indications and Usage, Adverse Reactions, Clinical Studies   Abemaciclib (2) Oncology ERBB2(HER2) Indications and Usage, Adverse Reactions, Clinical Studies   Abemaciclib (3) Oncology MKI67 Indications and Usage, Dosage and Administration,…

New, trends and future of RNA-based therapeutics Company’s OligoPhoreTM / SemaPhoreTM polyplexes provide for efficient delivery of siRNA payloads into extrahepatic target cells Company’s latest research and insights into RNA-based therapies Alternatives to LNPs and how Altamira’s proprietary R&D is different from lipid-based solutions HAMILTON, BERMUDA / ACCESSWIRE / February…

Expert oncologists review key updates regarding metastatic colorectal cancer from recent meetings and discuss their implications on real-world clinical practice. At a recent Around the Practice program hosted by CancerNetwork®, experts discussed the use of molecular and genetic testing to better treat patients with metastatic colorectal cancer (CRC). The panel…

World Cancer Day offers a platform to raise the awareness of the latest advancements in oncology that are changing both the treatment of patients and the practice of clinicians around the world. In this regard, Next Generation Sequencing (NGS) continues to be at the forefront of precision medicine in oncology….

The following is the summary of  “Clinical landscape of cell-free DNA alterations in 1671 patients with advanced biliary tract cancer” published in the December 2022 issue of Oncology by Berchuck, et al. Targeted medicines have revolutionized clinical care of advanced biliary tract cancer (BTC). In contrast to conventional tissue analysis,…

What does it mean in GSEA when HALLMARK_UV_RESPONSE_DN is upregulated ? how it’s down and upregulated? 0 What does it mean in GSEA when HALLMARK_UV_KRAS_SIGNALING_DN is upregulated ? how it’s down and upregulated? GSEA HALLMARK • 27 views • link updated 3 minutes ago by Papyrus ★ 2.3k • written…

Causes and consequences of replication stress. Nat. Cell Biol. 2014; 16: 2-9doi.org/10.1038/ncb2897 Tomasetti C. Li L. Vogelstein B. Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science. 2017; 355: 1330-1334doi.org/10.1126/science.aaf9011 Endogenous DNA damage as a source of genomic instability in cancer. Cell. 2017; 168: 644-656doi.org/10.1016/j.cell.2017.01.002 Halazonetis T.D. Gorgoulis…

Taped outside of the lab of Dr. Christopher Kemp, a professor in the Human Biology Division, hangs a piece of paper with an earlier version of the Fred Hutch logo- a DNA helix integrated between an “H” with the slogan, “Advancing Knowledge, Saving Lives”. Russell Moser, a research scientist in…

Huebner, H. et al. Filtration based assessment of CTCs and Cell Search® based assessment are both powerful predictors of prognosis for metastatic breast cancer patients. BMC Cancer 18, 204. doi.org/10.1186/s12885-018-4115-1 (2018). Article  Google Scholar  Banys-Paluchowski, M., Krawczyk, N. & Fehm, T. Liquid biopsy in breast cancer. Geburtshilfe Frauenheilkd 80, 1093–1104….

A rare group of gastrointestinal malignancies with a significant morbidity and death rate are biliary tract tumors. Most patients arrive with a locally progressed or metastatic illness that is incurable. It was possible to directly benefit from the pathophysiology of biliary tract cancer, and as a result, chemotherapy, precision medicine,…

Zhou, P. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579(7798), 270–273. doi.org/10.1038/s41586-020-2012-7 (2020). Article  ADS  CAS  PubMed  PubMed Central  Google Scholar  Lipsitch, M., Swerdlow, D. L. & Finelli, L. Defining the epidemiology of Covid-19—Studies needed. N. Engl. J. Med. 382(13), 1194–1196. doi.org/10.1056/NEJMp2002125…

Publications PubMed=1260746Drewinko B., Romsdahl M.M., Yang L.Y., Ahearn M.J., Trujillo J.M.Establishment of a human carcinoembryonic antigen-producing colon adenocarcinoma cell line.Cancer Res. 36:467-475(1976) PubMed=7104989; DOI=10.1016/0165-4608(82)90076-0Chen T.-R., Hay R.J., Macy M.L.Karyotype consistency in human colorectal carcinoma cell lines established in vitro.Cancer Genet. Cytogenet. 6:93-117(1982) PubMed=3335022Alley M.C., Scudiero D.A., Monks A., Hursey M.L.,…

Introduction Pancreatic cancer (PC) is one of the most aggressive and lethal cancers (1). Previous studies have shown that aging, environmental and behavioral changes are more closely related to the dramatic increase in the incidence of PC worldwide than genetic factors (2–5). A position paper published by the European Federation…

Introduction Antimicrobials are the most important and useful therapeutic discovery in the history of medicine. It allows living beings to survive the microbial disease, enhances invasive surgical procedures, ensures animal health, and protects the food chain since 1928 after the discovery of penicillin. However, the indiscriminate use of antibiotics and…

Cell-type annotation scRNA-seq data were filtered to discard low-quality cells and doublets (Supplementary Fig. 1, Extended Data Fig. 1 and Methods). Supervised clustering (Reference Component Analysis v2 (RCA2)) at low resolution grouped cells into 11 major cell types (Extended Data Fig. 1). To identify epithelial cell subtypes, we initially analyzed…

You should read the following discussion and analysis of our financial condition and results of operations in conjunction with our unaudited condensed consolidated financial statements and related notes included in Part I, Item 1 of this report. This Quarterly Report on Form 10-Q contains forward-looking statements within the meaning of…

DUBLIN–(BUSINESS WIRE)–The “Global KRAS Inhibitors Market & Clinical Trials Forecast 2028” report has been added to ResearchAndMarkets.com‘s offering. The advancement in clinical research has led to the identification of several oncogenes that are generally mutated in cancers. Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most frequently mutated…

Introduction Lung cancer is the major leading cause of tumour-related deaths throughout the world, while lung squamous cell carcinoma (LUSC) as the second most common histological type of lung cancer.1 Each year, almost 1.8 million people are diagnosed with lung cancer worldwide and 400,000 of these die from LUSC.2,3 Due to…