Tag: LiP-MS

Changes in Protein Structure May Act as Parkinson’s Biomarkers | Potential for Easier Diagnosis in Analysis of Protein Shape

Changes in the structure of 76 proteins in the cerebrospinal fluid (CSF) of people with Parkinson’s disease were seen when compared with those of healthy individuals, a study reported. Its researchers believe their work is the first to look at protein structure — rather than abundance — to identify potential new…

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The Shape Of Proteins In Spinal Fluid Could Diagnose Parkinson’s Disease

Parkinson’s disease is on the rise as average ages increase, but treatment is often delayed through difficulties in distinguishing its early symptoms from other conditions. The discovery that proteins in a patient’s spinal fluid have distinctive structures could address this problem. It could also increase our understanding of the causes…

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Time for Proteomics To Shine

This article includes research findings that are yet to be peer-reviewed. Results are therefore regarded as preliminary and should be interpreted as such. Find out about the role of the peer review process in research here. For further information, please contact the cited source. Over the last 20 years, advances…

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An R package for comprehensive data analysis of peptide- and protein-centric bottom-up proteomics data

Overview of protti functions. protti can be used on the output of any software package for quantitative analysis of bottom-up proteomics experiments and provides a flexible set of functions for quality control, as well as data pre-processing, data analysis and data interpretation. Credit: Bioinformatics Advances (2021). DOI: 10.1093/bioadv/vbab041 A recent…

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Bottom-Up Proteomics and LiP-MS Quality Control and Data Analysis Tools

Peptides are mapped onto PDB structures or AlphaFold prediction based on their positions. This is accomplished by replacing the B-factor information in the structure file with values that allow highlighting of peptides, protein regions or amino acids when the structure is coloured by B-factor. In addition to simply highlighting peptides,…

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