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Tag: Lynch
The immense challenge of cancer vaccines: ‘There are promising results’ | Science
The dream of a cancer vaccine — capable of stimulating the immune system to fight tumors — is on the horizon of the scientific community. It probably has never been as close as it is now. After years of few successes in this field, the consolidation of other immunotherapies and…
Seroprevalence and Molecular Characterization of B. abortus
Introduction Brucellosis is a zoonotic disease caused by Brucella spp., a gram-negative facultative intracellular coccobacillus.1 These microorganisms can infect livestock, wildlife, and humans, causing significant public concern and substantial agricultural economic loss. Currently, at least six novel Brucella species have been identified: Brucella pinnipedialis, Brucella ceti,2 Brucella papionis,3 Brucella microti,4…
Unified Patents Gets PTAB To Trim VL Collective Data Patent
By Ryan Lynch (December 19, 2023, 5:37 PM EST) — In a favorable ruling for Unified Patents, the Patent Trial and Appeal Board has found that most challenged claims in a VL Collective patent for synchronizing data segments were invalid…. Law360 is on it, so you are, too. A Law360…
The Next Chapter in Genome Editing? Tome Emerges from Stealth with $213M
Rahul Kakkar, MD, Tome Biosciences president and CEO While the CRISPR community celebrates the recent first FDA approval of a CRISPR-Cas9 therapy (Casgevy), new entities are making strides in their efforts to write perhaps the definitive new chapter in programmable genome editing. Last week, Tome Biosciences—a developer of genome editing…
Perception of genomic newborn screening among peripartum mothers
Therrell BL, Padilla CD, Loeber JG, Kneisser I, Saadallah A, Borrajo GJC, et al. Current status of newborn screening worldwide: 2015. Semin Perinatol. 2015;39:171–87. Article PubMed Google Scholar Battelino T, Kržišnik C, Pavlin K. Early detection and follow-up of children with phenylketonuria in Slovenia. Zdr Vestn. 1994;63:25–8. Google Scholar Lampret…
Programmable Genomic Integration Company Raises Over $200 Million
Tome Biosciences – a programmable genomic integration company – recently announced it has launched to usher in a new era of genomic medicines based on programmable genomic integration (PGI). PGI enables the insertion of any DNA sequence of any size into any programmed genomic location. And the company has raised…
AI Week In Review 23.12.16
Figure 1. Tesla’s Optimus Gen2 demo video, showing off tactile precision. Midjourney Alpha web interface is available here to super-users who generated over 10k Midjourney images. This will be a big UX upgrade for Midjourney users over the discord text prompt method. Google has released Imagen2 text-to-image generation for Vertex…
Study finds revolutionary cancer vaccine simultaneously kills and prevents brain cancer
[Dec. 17, 2023: JJ Shavit, The Brighter Side of News] Dual action cell therapy is engineered to eliminate established tumors and train the immune system to eliminate the primary tumor and prevent cancer recurrence. (Credit: Creative Commons) In a bold effort to rewrite the story of cancer treatment, scientists are…
Precision Medicine: A New Era in Cancer Therapy
Precision medicine can offer improved clinical outcomes by assessing the unique characteristics of tumors, such as their likelihood of developing resistance to chemotherapy. Stay up to date on the latest science with Brush Up Summaries. Precision Medicine in Cancer Precision medicine for cancer treatment involves tailoring treatments to an individual…
Maternal dominance contributes to subgenome differentiation in allopolyploid fishes
Otto, S. P. & Whitton, J. Polyploid incidence and evolution. Annu. Rev. Genet. 34, 401–437 (2000). Article CAS PubMed Google Scholar Van de Peer, Y., Maere, S. & Meyer, A. The evolutionary significance of ancient genome duplications. Nat. Rev. Genet. 10, 725–732 (2009). Article PubMed Google Scholar Comai, L. The…
Genomic Predictors Associated With Exceptional Response to Systemic Therapy in Advanced Pancreatic Cancer
ABSTRACT Introduction: Exceptional response to therapy is rare in patients with advanced pancreatic cancer. This study explored potential genomic differences between typical and exceptional responses that could confer more favorable biology. Methods: We included exceptional responders and controls with advanced pancreatic cancer from Cleveland Clinic from April 2013 to August…
Tome Biosciences Launches with Over $200 Million in Funding to Advance Programmable Genomic Integration Platform
Tome Biosciences Launches with Over $200 Million in Funding to Advance Programmable Genomic Integration Platform Technology, in-licensed from the Massachusetts Institute of Technology (MIT), capable of inserting DNA sequences of any size into any programmed genomic location Potential to create curative cell and integrative gene therapies Backed by leading biotech…
Effects of diabetes mellitus and glycemic traits on cardiovascular morpho-functional phenotypes | Cardiovascular Diabetology
American Diabetes A. Economic costs of Diabetes in the U.S. in 2017. Diabetes Care. 2018;41(5):917–28. Article Google Scholar Linssen PBC, Veugen MGJ, Henry RMA, van der Kallen CJH, Kroon AA, Schram MT, Brunner-La Rocca HP, Stehouwer CDA. Associations of (pre)Diabetes with right ventricular and atrial structure and function: the Maastricht…
The MetaInvert soil invertebrate genome resource provides insights into below-ground biodiversity and evolution
FAO, ITPS, GSBI, CBD & EC. State of knowledge of soil biodiversity – Status, challenges and potentialities, Report 2020. (FAO). doi.org/10.4060/cb1928en. 2020. Potapov, A. M. et al. Feeding habits and multifunctional classification of soil-associated consumers from protists to vertebrates. Biol. Rev. 97, 1057–1117 (2022). Article PubMed Google Scholar García-Palacios, P.,…
Land transactions for Nov. 13-17 – Shelby County Reporter
Land transactions for Nov. 13-17 Published 3:34 pm Monday, December 4, 2023 The following deeds were transferred in Shelby County from Nov. 13-17: Nov. 13 -Freedom Driven Properties LLC to Kenneth Kirkes, for $188,500, for Lot 1 in Tucker Estate Survey Resubdivision of Lot 1A of a Resurvey of…
Moffitt Innovators of Tomorrow Symposium Welcomes Its First Recruited Postdoc, Dr. Hayley du Bois
Research Education & Training is excited to welcome Dr. Haley du Bois back to campus as a new postdoctoral fellow in the lab of Dr. Conor Lynch. Dr. du Bois first visited campus in May as part of the inaugural cohort of the Moffitt Innovators of Tomorrow (MIOT) Symposium, our newest…
Genomic evidence that microbial carbon degradation is dominated by iron redox metabolism in thawing permafrost
Tarnocai C, Canadell JG, Schuur EA, Kuhry P, Mazhitova G, Zimov S. Soil organic carbon pools in the northern circumpolar permafrost region. Global Biogeochem Cycles. 2009;23:1–11. Article Google Scholar Hugelius G, Strauss J, Zubrzycki S, Harden JW, Schuur EA, Ping CL, et al. Estimated stocks of circumpolar permafrost carbon with…
Flagship Pioneering Launches First UK Biotech with $50M Investment
Pictured: A 3D illustration of a DNA particle complex /iStock, peterschreiber.media Investment firm Flagship Pioneering on Tuesday launched its first U.K. biotech. Quotient Therapeutics, a company studying genetic variation on the cellular level, joins 41 other companies in the firm’s ecosystem. After a two-year incubation period in the investment firm,…
ARFID Genes and Environment (ARFID-GEN): study protocol | BMC Psychiatry
Dinkler L, Bryant-Waugh R. Assessment of avoidant restrictive food intake disorder, pica and rumination disorder: interview and questionnaire measures. Curr Opin Psychiatry. 2021;34(6):532–42. Article Google Scholar American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (5th ed.). Arlington, VA: American Psychiatric Publishing; 2013. Thomas JJ, Lawson EA, Micali N, Misra…
Prognostic potential of circulating cell free mitochondrial DNA levels in COVID-19 patients
Wang C, Horby PW, Hayden FG, Gao GF (2020) A novel coronavirus outbreak of global health concern. The Lancet 395(10223):470–473 Article CAS Google Scholar Lynch SM, Guo G, Gibson DS, Bjourson AJ, Rai TS (2021) Role of senescence and aging in SARS-CoV-2 infection and COVID-19 disease. Cells 10(12):3367 Article CAS …
DNA study reveals BRCA1 mutations in three sisters, prompts life-changing decisions
Sisters left to right: Chris Swatfager, Cindy Larson, Carrie Patnode and Amy Scheid. Credit: Chris Swatfager Sisters often share certain genetic traits, such as hair color and facial features. But for three sisters from Minnesota, they discovered a much deeper connection—a shared genetic mutation known to dramatically increase their risk…
WellSpan peers into patient DNA as part of effort to detect and prevent diseases earlier
The York Dispatch receives a ‘cosmic check-in’ from Hanover shop targeted by obscure law Reporter Tina Locurto sat down with Beck Lawrence to receive a tarot reading and learn more about what the practice is. New advancements in genealogy research at WellSpan Health could help patients detect diseases and disorders…
Bacterial SNPs in the human gut microbiome associate with host BMI
Lynch, S. V. & Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med. 375, 2369–2379 (2016). Article CAS PubMed Google Scholar Manichanh, C. et al. Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach. Gut 55, 205–211 (2006). Article CAS PubMed …
What is FastQC | 5 Answers from Research papers
FastQC is a software tool used for quality control in sequencing data analysis. It is commonly used in standard pipelines at sequencing centers. The tool provides computations to assess the quality of sequencing data, such as per base sequence content and per tile sequence quality. It generates HTML reports with…
Phase separation in cGAS-STING signaling
Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013; 339(6121): 786–791 Article CAS PubMed Google Scholar Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. Cyclic GMP-AMP…
Liquid Biopsy Provides Earlier Detection of an Inherited Cancer
Credit: AlexRaths/iStock Researchers at the Hospital for Sick Children (SickKids), the Ontario Institute for Cancer Research (OICR), and the University Health Network (UHN) have developed a liquid biopsy that an initial study has shown provides earlier detection cancer in individuals with Li-Fraumeni syndrome (LFS) than existing methods. LFS is hereditary…
For Those With Lynch Syndrome, Exercise May Be A Useful Defense Against Colorectal Cancer
Amanda Brink, DNP, APRN, FNP-BC, AOCNP Colorectal cancer (CRC) currently ranks as the fourth most commonly diagnosed cancer and the second leading cause of cancer-related deaths in the United States.1 While most CRCs cases arise sporadically, between 5 and 10% of cases are attributed to hereditary cancer syndromes.2 Lynch syndrome,…
Liquid Biopsy Detects Cancer Earlier in Patients with Inherited Disorder
Researchers at the Hospital for Sick Children (SickKids), the Ontario Institute for Cancer Research (OICR), and the University Health Network (UHN) have developed a method for analyzing blood samples that an initial study has shown can detect cancer in individuals with Li-Fraumeni syndrome (LFS) earlier than existing surveillance methods. LFS…
Genome-wide association study of traumatic brain injury in U.S. military veterans enrolled in the VA million veteran program
Helmick KM, Spells CA, Malik SZ, Davies CA, Marion DW, Hinds SR. Traumatic brain injury in the US military: Epidemiology and key clinical and research programs. Brain Imaging Behav. 2015;9:358–66. Article PubMed Google Scholar DoD Numbers for Traumatic Brain Injury Worldwide – Totals (Defense Health Agency) (2021). Karr JE, Areshenkoff…
The Age of Aquarius – RNA, the Epicenter of Genetic Information
The veil on genetic information was lifted by the advent of gene cloning and sequencing technologies in the 1970s. The discovery and purification of bacterial nucleases capable of cutting DNA at specific sequences and ligases capable of joining them enabled DNA from any species – or mRNAs converted to complementary…
Rational probe design for efficient rRNA depletion and improved metatranscriptomic analysis of human microbiomes
doi: 10.1186/s12866-023-03037-y. Asako Tan # 1 , Senthil Murugapiran # 2 , Alaya Mikalauskas # 3 , Jeff Koble 4 , Drew Kennedy 4 , Fred Hyde 1 , Victor Ruotti 1 , Emily Law 2 , Jordan Jensen 2 , Gary P Schroth 4 , Jean M Macklaim 3 , Scott Kuersten 5 , Brice LeFrançois 6 , Daryl M Gohl 7 8 …
Rational probe design for efficient rRNA depletion and improved metatranscriptomic analysis of human microbiomes | BMC Microbiology
Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012;13:260–70. Article CAS PubMed PubMed Central Google Scholar Gilbert JA, Blaser MJ, Caporaso JG, Jansson JK, Lynch SV, Knight R. Current understanding of the human microbiome. Nat Med. 2018;24:392 NIH Public Access. Article …
Low mutation rate in epaulette sharks is consistent with a slow rate of evolution in sharks
Compagno, L. J. V. Alternative life-history styles of cartilaginous fishes in time and space. Environ. Biol. Fishes 28, 33–75 (1990). Article Google Scholar Kriwet, J., Witzmann, F., Klug, S. & Heidtke, U. H. J. First direct evidence of a vertebrate three-level trophic chain in the fossil record. Proc. Biol. Sci….
Range-wide and temporal genomic analyses reveal the consequences of near-extinction in Swedish moose
Ceballos, G., Ehrlich, P. R. & Raven, P. H. Vertebrates on the brink as indicators of biological annihilation and the sixth mass extinction. Proc. Natl Acad. Sci. USA 117, 13596–13602 (2020). Article CAS PubMed PubMed Central Google Scholar Ceballos, G., Ehrlich, P. R. & Dirzo, R. Biological annihilation via the…
Short’s Brewing End of Year Release Schedule Has Arrived
ELK RAPIDS, Mich.— How much awesome can you pack into three months? If you’re Short’s Brewing, the answer is a whole heckin’ lot. The brewers year end releases have been announced, and with a line up this good, we can only imagine what Short’s has in store…
Advances in Polatuzumab Vedotin-PIIQ Therapy
Introduction Between 30 to 40% of non-Hodgkin lymphoma cases globally are diffuse B-cell lymphoma (DLBCL), the most prevalent disease. Patients often have a rapidly expanding nodal or extranodal tumor mass in one or more locations.1 The concept of “high-grade B-cell lymphoma” has historically been used to refer to B-cell lymphomas…
DNA Sequencing Patent Survives Guardant PTAB Challenge
By Ryan Lynch (October 11, 2023, 9:12 PM EDT) — The Patent Trial and Appeal Board has ruled that Guardant Health failed to show that challenged claims in a University of Washington patent for DNA sequencing were unpatentable, ahead of an infringement trial set for next month…. Law360 is on…
Assessing Cancer Risk? Here’s What the New DNA Test Can Do
A novel DNA test system that assesses a person’s genetic predisposition for certain cancers —the first of its kind granted marketing authorization by the US Food and Drug Administration (FDA) — may become a valuable new public health tool. The Common Hereditary Cancers Panel (Invitae Corp.) was approved late last…
Five bioart artists you should know about
Bioart bridges art, born out of creativity and abstract thoughts, and science, which is rooted in facts, laws and logic, as a means of self-expression. The term bioart was coined by Brazilian-American artist Eduardo Kac, who implanted a microchip in his ankle on live television, and registered himself in a…
Invitae’s First of Its Kind Cancer Test Receives FDA Marketing Authorization
Mutations to the BRCA1 and BRCA2 genes significantly increase the chances of breast and ovarian cancers, and a test can assess a person’s risk from those variants. But those are just two genes of many known genetic drivers of cancer. The FDA has granted marketing authorization to an Invitae test…
First Blood Test for Dozens of Hereditary Cancers Approved by FDA
Credit: Nadasaki / Getty Images The FDA has approved the first blood test that can help identify hundreds of potentially cancer-associated hereditary variants. The Invitae Common Hereditary Cancers Panel evaluates a blood sample to identify DNA variants in 47 genes associated with an elevated risk of developing certain types of…
Predicting tumour content of liquid biopsies from cell-free DNA | BMC Bioinformatics
Forshew T, Murtaza M, Parkinson C, Gale D, Tsui DWY, Kaper F, et al. Noninvasive identification and monitoring of cancer mutations by targeted deep sequencing of plasma DNA. Sci Transl Med. 2012;4(136):136ra68. Article PubMed Google Scholar Newman AM, Bratman SV, To J, Wynne JF, Eclov NCW, Modlin LA, et al….
FDA Grants First Marketing Authorization for a DNA Test to Assess Predisposition for Dozens of Cancer Types
For Immediate Release: September 29, 2023 Today, the U.S. Food and Drug Administration granted de novo marketing authorization for the Invitae Common Hereditary Cancers Panel, an in vitro diagnostic test that can help detect hundreds of genetic variants associated with an elevated risk of developing certain cancers. The test can…
Induced Pluripotent Stem Cells (iPSCs) and Genetic Engineering
Benabdellah, K., Sánchez-Hernández, S., Aguilar-González, A., Maldonado-Pérez, N., Gutierrez-Guerrero, A., Cortijo-Gutierrez, M., Ramos-Hernández, I., Tristán-Manzano, M., Galindo-Moreno, P., Herrera, C., & Martin, F. (2020). Genome-edited adult stem cells: Next-generation advanced therapy medicinal products. Stem Cells Translational Medicine, 9(6), 674–685. doi.org/10.1002/sctm.19-0338 Chang, C. W., Lai, Y. S., Pawlik, K. M., Liu,…
Species-specific responses of marine bacteria to environmental perturbation
Worden AZ, Follows MJ, Giovannoni SJ, Wilken S, Zimmerman AE, Keeling PJ. Rethinking the marine carbon cycle: Factoring in the multifarious lifestyles of microbes. Science. 2015;347:1257594–1257594. PubMed Google Scholar Moran MA. The global ocean microbiome. Science. 2015;350:aac8455–aac8455. PubMed Google Scholar Sunagawa S, Coelho LP, Chaffron S, Kultima JR, Labadie K,…
Genetic testing and unnecessary breast surgery in women
Genetic testing has become crucial for assessing an individual’s risk of hereditary cancers, including breast cancer. However, the accuracy of these tests and their interpretation, especially in relation to family history, can significantly impact clinical decisions. This study aims to shed light on whether women with a family history of…
Mitochondrially mediated RNA interference, a retrograde signaling system affecting nuclear gene expression
Andersson DI, Jerlstrom-Hultqvist J, Nasvall J (2015) Evolution of new functions de novo and from preexisting genes. Cold Spring Harb Perspect Biol 7:a017996 Article PubMed PubMed Central Google Scholar Andrews S (2010) FastQC: a quality control tool for high throughput sequence data. www.bioinformatics.babraham.ac.uk/projects/fastqc/ Auyeung VC, Ulitsky I, McGeary SE, Bartel…
Genetic Testing Risk Inflation May Lead to Unneeded Breast Surgeries
Women could be opting to have unnecessary surgery to avoid breast cancer, after being told they are at high risk from genetic test results which do not take family history into account. The authors of new research led by the University of Exeter have warned that women who discover, outside…
Genetic Testing Market – Top a Valuation of USD 39.2 Bn by
New York, Sept. 11, 2023 (GLOBE NEWSWIRE) — According to Market.us, the Global Genetic Testing Market size is projected to surpass around USD 39.2 billion by 2032, and it is poised to reach a CAGR of 9.7% from 2023 to 2032. Genetic testing is a specialized medical examination designed to detect…
Genetic Cancer Hereditary Cancer Mutations Susceptibility To Cancer Genetic Changes
Genetic Cancers: Welcome back to “The Science Of Health”, ABP Live’s health column. Last time, in the health column, we discussed the difference between small cell lung cancers and non-small cell lung cancers, and explained why small cell lung cancers are less common than non-small cell lung cancers, despite the…
Gut Microbiome of Children with Airway Allergic Disease
Introduction Allergic airway diseases affect many people worldwide, and incidences are still increasing gradually. Allergic rhinitis and allergic asthma, are typical chronic nasopharyngitis respiratory diseases in pediatric, causing an enormous burden of illness and high economic costs to the community.1 Allergic rhinitis and allergic asthma are immunoglobulin E (IgE)-mediated inflammatory…
A second update on mapping the human genetic architecture of COVID-19
Broad Institute of MIT and Harvard, Cambridge, MA, USA Masahiro Kanai, Christine Stevens, Benjamin M. Neale, Mark Daly, Andrea Ganna, Amy Trankiem, Mary K. Balaconis, Samuli Ripatti, Lindo Nkambul, Mark J. Daly, Sam Bryant & Matthew Solomonson University of California San Francisco, San Francisco, CA, USA Shea J. Andrews Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland Mattia Cordioli, Mark…
Neighborhood socioeconomic status is associated with low diversity gut microbiomes and multi-drug resistant microorganism colonization
Buettgens, M., Blavin, F. & Pan, C. The affordable care act reduced income inequality in the US. Health Aff. 40, 121–129 (2021). Article Google Scholar Chen, E. & Miller, G. E. Socioeconomic status and health: mediating and moderating factors. Annu. Rev. Clin. Psychol. 9, 723–749 (2013). Article PubMed Google Scholar …
Nodulation number tempers the relative importance of stochastic processes in the assembly of soybean root-associated communities
Vandenkoornhuyse P, Quaiser A, Duhamel M, Le Van A, Dufresne A. The importance of the microbiome of the plant holobiont. New Phytol. 2015;206:1196–206. doi.org/10.1111/nph.13312. Article PubMed Google Scholar Zhou J, Ning D. Stochastic Community Assembly: Does It Matter in Microbial Ecology? Microbiol Mol Biol Rev. 2017;81. doi.org/10.1128/MMBR.00002-17. Fitzpatrick CR, Salas-González…
Conversion of steppe to cropland increases spatial heterogeneity of soil functional genes
Forrest JR, Thorp RW, Kremen C, Williams NM. Contrasting patterns in species and functional-trait diversity of bees in an agricultural landscape. J Appl Ecol. 2015;52:706–15. Article Google Scholar Mbuthia LW, Acosta-Martínez V, DeBruyn J, Schaeffer S, Tyler D, Odoi E, et al. Long term tillage, cover crop, and fertilization effects…
GEDmatch Loophole Gave Police Access to Private DNA Data
CeCe Moore, an actress and director-turned-genetic genealogist, stood behind a lectern at New Jersey’s Ramapo College in late July. Propelled onto the national stage by the popular PBS show “Finding Your Roots,” Moore was delivering the keynote address for the inaugural conference of forensic genetic genealogists at Ramapo, one of…
Helix, Nebraska Medicine Partner to Launch Genomic Health-Risk Screening Program
NEW YORK – Population genomics firm Helix said Tuesday that it has partnered with Nebraska Medicine to launch the Genetic Insights Project, in which Helix will provide testing to identify individuals with an elevated risk of cancer and other potentially life-threatening diseases while also collecting broader genomic data for research…
The progress of novel strategies on immune-based therapy in relapsed or refractory diffuse large B-cell lymphoma
Susanibar-Adaniya S, Barta SK. 2021 Update on diffuse large B cell lymphoma: a review of current data and potential applications on risk stratification and management. Am J Hematol. 2021;96:617–29. Article PubMed PubMed Central Google Scholar Rovira J, Valera A, Colomo L, Setoain X, Rodriguez S, Martinez-Trillos A, et al. Prognosis…
Altitude Marketing Announces Branding & Marketing Partnership with LS CancerDiag
Altitude Marketing, a full-service life sciences marketing and branding agency serving B2B companies for more than 19 years, recently announced a partnership with LS CancerDiag, the distinguished experts behind the groundbreaking DiagMMR® assay. EMMAUS, Pa. , Aug. 10, 2023 /PRNewswire/ — LS CancerDiag’s ultimate mission is to reduce cancer mortality…
Comparative transcriptome profiling to unravel the key molecular signalling pathways and drought adaptive plasticity in shoot borne root system of sugarcane
Shrivastava, A. K. & Srivastava, S. Sugarcane: Physiological and molecular approaches for improving abiotic stress tolerance and sustaining crop productivity. (ed. Narendra Tuteja et al.) 885–992 (Wiley Blackell, Weinheim, 2012). Reyes, J. A. O., Casas, D. E., Gandia, J. L. & Delfin, E. F. Agricultural Research Updates Vol. 35 (ed…
Invasion success of a Lessepsian symbiont-bearing foraminifera linked to high dispersal ability, preadaptation and suppression of sexual reproduction
Simberloff, D. et al. Impacts of biological invasions: What’s what and the way forward. Trends Ecol. Evol. 28, 58–66 (2013). Article PubMed Google Scholar Bellard, C., Cassey, P. & Blackburn, T. M. Alien species as a driver of recent extinctions. Biol. Lett. doi.org/10.1098/rsbl.2015.0623 (2016). Article PubMed PubMed Central Google Scholar …
Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture.
Authors: Louise C Laurent, Igor Ulitsky, Ileana Slavin, Ha Tran, Andrew Schork, Robert Morey, Candace Lynch, Julie V Harness, Sunray Lee, Maria J Barrero, Sherman Ku, Marina Martynova, Ruslan Semechkin, Vasiliy Galat, Joel Gottesfeld, Juan Carlos Izpisua Belmonte, Chuck Murry, Hans S Keirstead, Hyun-Sook Park, Uli Schmidt, Andrew L Laslett,…
Contrasting whole-genome and reduced representation sequencing for population demographic and adaptive inference: an alpine mammal case study
Aguirre-Liguori JA, Ramírez-Barahona S, Gaut BS (2021) The evolutionary genomics of species’ responses to climate change. Nat Ecol Evol 5:1350–1360. doi.org/10.1038/s41559-021-01526-9 Article PubMed Google Scholar Andrews KR, Good JM, Miller MR, Luikart G, Hohenlohe PA (2016) Harnessing the power of RADseq for ecological and evolutionary genomics. Nat Rev Genet 17:81–92….
The potential role of the microbiota in prostate cancer pathogenesis and treatment
Lynch, S. V. & Pedersen, O. The human intestinal microbiome in health and disease. N. Engl. J. Med. 375, 2369–2379 (2016). Article CAS PubMed Google Scholar Qin, J. et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 464, 59–65 (2010). Article CAS PubMed PubMed Central Google…
High incidence of AZF duplications in clan-structured Iranian populations detected through Y chromosome sequencing read depth analysis
Skaletsky, H. et al. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423, 825–837 (2003). Article ADS CAS PubMed Google Scholar Trombetta, B. & Cruciani, F. Y chromosome palindromes and gene conversion. Hum. Genet. 136, 605–619 (2017). Article CAS PubMed Google Scholar …
Life Science Tennessee and BioTN Foundation Congratulate Nashville Biosciences’ Formation of the Alliance for Genomic Discovery
Nashville Biosciences, VUMC’s extensive genomic and bioinformatics database subsidiary, has partnered with five of the world’s leading pharma companies to create the largest de-identified WGS database in the world NASHVILLE, Tenn.–(BUSINESS WIRE)–Nashville Biosciences (NB), a wholly owned subsidiary of Vanderbilt University Medical Center (VUMC), has announced a partnership with five…
What doctors wish patients knew about precision medicine
In the rapidly evolving health care landscape, precision medicine—also referred to as personalized medicine—has emerged as a revolutionary approach that tailors medical treatments to individual patients. By harnessing the power of advanced technologies and genetic insights, precision medicine is transforming the way we understand and treat diseases. For patients, though,…
IJMS | Free Full-Text | DNA Methylation in the Fields of Prenatal Diagnosis and Early Detection of Cancers
1. DNA Methylation: Looking Back over the Century “Genes are equivalent to blueprints; epigenetics is the contractor. They change the assembly, the structure.” —Bruce Lipton. The methylation of the DNA is a quintessential epigenetic mechanism consisting of the binding of a methyl group to the fifth carbon of the cytosine…
Gastrointestinal symptoms of long COVID-19 related to the ectopic colonization of specific bacteria that move between the upper and lower alimentary tract and alterations in serum metabolites | BMC Medicine
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan. China JAMA. 2020;323(11):1061–9. Article CAS PubMed Google Scholar Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y, Zuo W. Single-cell RNA expression…
Identification of a deep-branching thermophilic clade sheds light on early bacterial evolution
Lieph, R., Veloso, F. A. & Holmes, D. S. Thermophiles like hot T. Trends Microbiol. 14, 423–426 (2006). Article CAS PubMed Google Scholar Hedlund, B. P. et al. Uncultivated thermophiles: current status and spotlight on ‘Aigarchaeota’. Curr. Opin. Microbiol. 25, 136–145 (2015). Article CAS PubMed Google Scholar Kato, S. et…
Smaller Australian raptors have greater urban tolerance
Grimm, N. B. et al. Global change and the ecology of cities. Science 319, 756–760. doi.org/10.1126/science.1150195 (2008). Article ADS CAS PubMed Google Scholar Aronson, M. F. J. et al. Hierarchical filters determine community assembly of urban species pools. Ecology 97, 2952–2963. doi.org/10.1002/ecy.1535 (2016). Article PubMed Google Scholar Shochat, E. et…
A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth | BMC Medicine
Martin JA, Hamilton BE, Osterman MJK, Driscoll AK. Births: Final Data for 2018. Natl Vital Stat Rep. 2019;68:1–47. PubMed Google Scholar Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, et al. Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with…
Patch-clamp studies and cell viability assays suggest a distinct site for viroporin inhibitors on the E protein of SARS-CoV-2 | Virology Journal
Liu J, Xie W, Wang Y, Xiong Y, Chen S, Han J, Wu Q. A comparative overview of COVID-19, MERS and SARS: review article. Int J Surg. 2020;81:1–8. Article PubMed PubMed Central Google Scholar Farag NS, Breitinger U, Breitinger HG, El Azizi MA. Viroporins and inflammasomes: a key to understand…
hypervariable region of 16s rrna
The mock community was created from pure cultures, whose 16S rRNA genes were determined through Sanger sequencing to be >3% different (Table S1). Bartram, Andrea. WebWhile 16S hypervariable region analysis is a powerful tool for bacterial taxonomic studies, it struggles to differentiate between closely related species. Limited by sequencing Rarefaction…
Dissemination and genome characterization of a human adenovirus F41 in a patient with B-Cell lymphoma | Virology Journal
Lynch JP 3rd, Kajon AE. Adenovirus: Epidemiology, Global Spread of Novel types, and Approach to Treatment. Semin Respir Crit Care Med. 2021;42:800–21. Seto D, Chodosh J, Brister JR, Jones MS. Using the whole-genome sequence to characterize and name human adenoviruses. J Virol. 2011;85:5701–2. Article CAS PubMed PubMed Central Google Scholar …
Are we ready for genomic newborn screening?
Introduction Newborn screening (NBS) is one of the world’s most successful population screening initiatives.1 It aims to identify newborns with serious but treatable conditions prior to the onset of clinically detectable symptoms, in order to prevent irreversible damage or death.2,3 When implemented successfully, NBS programs screen >99% of newborns and…
Sequence variants affecting the genome-wide rate of germline microsatellite mutations
STR identification and genotyping We used popSTR34 to call genotypes at 5,401,401 autosomal short tandem repeats (STRs) in two large WGS data sets, 53,026 Icelanders and 150,119 participants in the UK Biobank (UKB), sequenced to an average coverage of 39.2× (min: 19.7, max: 608.3) and 32.5× (min: 23.6, max: 128.1),…
Identifying the function of genes involved in excreted vesicle formation in Acanthamoeba castellanii containing Legionella pneumophila | Parasites & Vectors
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Mismatch Repair Deficiency Shapes Tumor-Agnostic Use of Immunotherapy
Cancer immunotherapies have transformed the treatment landscape of many tumor types by stimulating the body’s mechanisms of targeting cancer cells. The efficacy of immune checkpoint inhibitors (ICIs) can vary widely between different tumor types based on immunogenicity and other factors—even patients with the same disease may respond very differently to…
Molecular characterisation of human adenoviruses associated with respiratory infections in Uganda | BMC Infectious Diseases
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Bioconductor – illuminaHumanv2.db
DOI: 10.18129/B9.bioc.illuminaHumanv2.db Illumina HumanWG6v2 annotation data (chip illuminaHumanv2) Bioconductor version: Release (3.17) Illumina HumanWG6v2 annotation data (chip illuminaHumanv2) assembled using data from public repositories Author: Mark Dunning, Andy Lynch, Matthew Eldridge Maintainer: Mark Dunning <mark.dunning at cruk.cam.ac.uk> Citation (from within R, enter citation(“illuminaHumanv2.db”)): Installation To install this package, start…
Impact of nanopore-based metagenome sequencing on tick-borne virus detection
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First case of endometrial cancer after yolk sac tumor in a patient with Li-Fraumeni syndrome | BMC Women’s Health
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Which factors contribute to skin neoplasms in Lynch syndrome patients? | Latest news for Doctors, Nurses and Pharmacists
Individuals with Lynch syndrome (LS) often develop skin neoplasms, reports a recent study, which has identified several clinical factors that contribute to LS- and non-LS-related skin neoplasms. To characterize the clinical factors associated with the development of skin neoplasms in LS, the authors systematically obtained data on a cohort of…
Cross-phenotype relationship between opioid use disorder and suicide attempts: new evidence from polygenic association and Mendelian randomization analyses
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Enabling Realtime Work in the Field for Genomic Testing of Infectious Diseases
With this article, Contagion is presenting its first Clinical Corner column, which is a dedicated column designed to looking at the science of infectious disease through research, understanding the current literature, and personal insights and opinions on the specialty. The work being done by researchers in the far reaches of…
Associations Between Clinical Factors and Skin Neoplasms in Longitudinal Observational Cohort of Individuals with LS
The following is a summary of “Clinical factors associated with skin neoplasms in individuals with Lynch syndrome in a longitudinal observational cohort,” published in the JUNE 2023 issue of Dermatology by Zhong, et al. For a study, researchers sought to identify clinical factors associated with developing skin neoplasms in individuals…
Culturing of a complex gut microbial community in mucin-hydrogel carriers reveals strain- and gene-associated spatial organization
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Assessment of genetic polymorphisms associated with malaria antifolate resistance among the population of Libreville, Gabon | Malaria Journal
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PD-1 blockade combined with ICE regimen in relapsed/refractory diffuse large B-cell lymphoma
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Transforming Diagnosis and Therapeutics Using Cancer Genomics
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What was the prevalence of germline genetic testing among patients diagnosed with cancer in California and Georgia between 2013 and 2019?
In a recent article published in the JAMA Network, researchers performed an observational study to determine the prevalence of germline genetic testing among all patients aged 20 years or older diagnosed with cancer between January 1, 2013, and March 31, 2019, in two United States (US), California and Georgia. Study:…
High speciation rate of niche specialists in hot springs
Shock EL, Holland M, Meyer-Dombard DA, Amend JP, Osburn GR, Fischer TP. Quantifying inorganic sources of geochemical energy in hydrothermal ecosystems, Yellowstone National Park, USA. Geochim Cosmochim Acta. 2010;74:4005–43. Article CAS Google Scholar Hou W, Wang S, Dong H, Jiang H, Briggs BR, Peacock JP, et al. A comprehensive census…
Large scale proteomic studies create novel privacy considerations
Funding Support and Acknowledgements: COPDGene: The project described was supported by Award Number U01 HL089897 and Award Number U01 HL089856 from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung,…
How Ireland connects AI and life sciences
Depending on your point of view, artificial intelligence (AI) can create jobs, make life easier, and solve many global problems; or, it’s going to cause mass unemployment, take over the world, and enslave humanity. In the life sciences space, AI is capable of tackling some of the biggest challenges when…
Transcriptomics and the origin of obligate parthenogenesis
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Fine-scale genomic tracking of Ross River virus using nanopore sequencing | Parasites & Vectors
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BabySeq Project Unearths Actionable Genetic Variants Impacting Infants, Parents
NEW YORK – The latest results from the BabySeq project suggest that unexpected, medically actionable variants in monogenic disease genes found by newborn genome screening can have clinical implications for both infants and their family members. “By screening apparently healthy newborns, entire families were alerted for the first time that…
Newborn sequencing IDs elevated disease risks for parents
Ten years ago, clinicians in a handful of hospitals around the United States began sequencing the genomes of apparently healthy babies, seeking to understand how the technology might turn up hidden genetic disorders that aren’t being caught by routine newborn blood testing. New research from one such trial suggests the…
Comparative analysis of bats and rodents’ genomes suggests a relation between non-LTR retrotransposons, cancer incidence, and ageing
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