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Tag: marr
ST23 Klebsiella pneumoniae in China
Introduction Klebsiella pneumoniae (KP), a member of the Enterobacteriaceae family, inhabits aquatic environments and can colonise respiratory and gastrointestinal tracts in humans, making it a significant opportunistic pathogen. It may result in pneumonia, meningitis, urinary tract infections, and bloodstream infections. Hypervirulent Kp (HvKp) is believed to cause severe community-acquired invasive…
RVFScan predicts virulence factor genes and hypervirulence of the clinical metagenome | Briefings in Bioinformatics
Abstract Bacterial infections often involve virulence factors that play a crucial role in the pathogenicity of bacteria. Accurate detection of virulence factor genes (VFGs) is essential for precise treatment and prognostic management of hypervirulent bacterial infections. However, there is a lack of rapid and accurate methods for VFG identification from…
Characteristics of Klebsiella pneumoniae co-infections
Introduction Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tuberculosis), is a prominent issue in the field of global public health, particularly in lower-middle-income-countries. Nearly two-thirds of global TB cases come from eight countries, including China.There are 780,000 new TB cases in China every year.1 TB is characterized by increased risk…
Detection and characterization of putative hypervirulent Klebsiella pneumoniae isolates in microbiological diagnostics
Navon-Venezia, S., Kondratyeva, K. & Carattoli, A. Klebsiella pneumoniae: A major worldwide source and shuttle for antibiotic resistance. FEMS Microbiol. Rev. 41(3), 252–275 (2017). Article CAS PubMed Google Scholar Marr, C. M. & Russo, T. A. Hypervirulent Klebsiella pneumoniae: A new public health threat. Expert Rev. Anti Infect. Ther. 17(2),…
Ralph Cram – File 770
(1) WAYS IN WHICH PRATCHETT IS STILL WITH US. Sam Jordison discusses “Pratchett power: from lost stories to new adaptations, how the late Discworld author lives on” in the Guardian. “Of all the dead authors in the world, Terry Pratchett is the most alive,” said John Lloyd at the author’s memorial in…
MacArthur Foundation announces 2023 ‘genius grant’ winners
Comment on this storyComment Ian Bassin would rather talk about the 2024 election — “one of the most consequential” in the history of this nation — but right now he must talk a little bit about himself. His grandparents used to tell him, repeatedly: “Just try to make something worthwhile…
ST11 and ST15 carbapenem-resistant hypervirulent Klebsiella
Introduction Klebsiella pneumoniae is a gram-negative opportunistic pathogen that can cause both community and hospital-acquired pneumonia, urinary tract infections, and bacteremia primarily in immunocompromised patients.1 Most experts agree that carbapenems are an effective treatment for serious infections brought on by Enterobacteriaceae that produce extended-spectrum beta-lactamases (ESBLs).2–4 Because of the wide…
KEGG T01001: 6419
Entry 6419 CDS T01001 Symbol SETMAR, METNASE, Mar1 Name (RefSeq) SET domain and mariner transposase fusion gene KO K11433 [histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357] Organism hsa Homo sapiens (human) Pathway hsa00310 Lysine degradation hsa01100 Metabolic pathways Brite KEGG Orthology (KO) [BR:hsa00001] 09100 Metabolism 09105 Amino acid metabolism 00310 Lysine degradation 6419 (SETMAR) 09180 Brite Hierarchies 09182 Protein families: genetic…
Comparative analysis of carbapenem-resistant K. pneumoniae
Introduction The worldwide spread of Klebsiella pneumoniae is a major global public health threat.1,2 K. pneumoniae is an opportunistic pathogen that colonizes the human gut and respiratory tract and possibly causes infection in immunocompromised hosts. Gut colonized K. pneumoniae is one of the important pathogens causing nosocomial infections, although the…
How IT pros can benefit from generative AI safely
The enterprise IT landscape is littered with supposedly paradigm-shifting technologies that failed to live up to the hype, and intil now, one could argue that AI fell into that category. But generative AI, which has taken the world by storm in the form of OpenAI’s ChatGPT chatbot, just might be…
DNA links tooth to Lincoln pilot missing since Vietnam War
Gift this article Share this article paywall-free. A ceremony was held for the unidentifiable remains of the USS Oklahoma from Pearl Harbor. The remains will be transported to Hawaii, where a group burial is planned. Just one tooth. A wisdom tooth. That’s all that’s left for Chief…
A review on blockchain for DNA sequence: security issues, application in DNA classification, challenges and future trends
Abadi M, Agarwal A, Barham P, et al. 2016 TensorFlow: large-scale machine learning on heterogeneous distributedsystems. Cornell University Library website. arxiv.org/abs/1603.04467. Published 2016. Accessed October 2016. Afshar P, Mohammadi A, Plataniotis KN. (2018) Brain tumor type classification via capsule networks, in Proc. 25th IEEE Int Conf Image Process. pp. 3129–3133….
Diversity and compositional differences of the airborne microbiome in a biophilic indoor environment
Klepeis, N. E. et al. The National Human Activity Pattern Survey (NHAPS): A resource for assessing exposure to environmental pollutants. J. Expo. Anal. Environ. Epidemiol. 11, 231–252 (2001). CAS PubMed Google Scholar Richardson, A. et al. Office design and health: A systematic review. N. Z. Med. J. 130, 39–49 (2017)….
Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution
Manrique, P., Dills, M. & Young, M. J. The human gut phage community and its implications for health and disease. Viruses 9, 141 (2017). Article PubMed PubMed Central Google Scholar Li, Z. et al. Deep sea sediments associated with cold seeps are a subsurface reservoir of viral diversity. ISME J….
The genomic epidemiology of Escherichia albertii infecting humans and birds in Great Britain
Summary of the human isolates Between January 2014 (when routine WGS was first implemented at the GBRU) and December 2021, 83 isolates from human cases were confirmed as E. albertii. Over this 8-year period, between 4 and 23 isolates were identified per year (Supplementary Fig. 1). Metadata regarding patient gender, age…
The Clinical Diagnostic Utility of Array CGH in Children with Syndromic Microcephaly
Abstract Background: A prospective study using array CGH in children with Syndromic microcephaly from a tertiary pediatric healthcare centre in India. Aim: To identify the copy number variations causative of microcephaly detected through chromosomal array CGH. Patients and Methods: Of the 60 patients, 33 (55%) males and 27 (45%) females…
Molecular Epidemiology of Klebsiella pneumoniae
Introduction Klebsiella pneumoniae (KPN) is a common gram-negative bacterium that causes clinical infection, and studies have shown that it has the second-highest detection rate among all bacterial infections.1,2 Compared with common KPN (ie classic KPN [cKP]), hypervirulent KPN (HvKP) has the following characteristics: (1) Usually, HvKP colonies display a high-mucus…
Why a decentralised approach to AI is a smoking gun
Last year, Meta published a blog explaining that it would be taking a new approach to how AI was organised in the company—moving from a central AI team to decentralised AI teams that sit within product groups to better drive integration with those teams while also focusing on cutting-edge research. “Now AI…
Extensively drug resistant E. coli LZ00114
Introduction Escherichia coli is a common Gram-negative opportunistic pathogen that causes invasive host infections through virulence factors such as flagella, toxin secretion, and adhesins. According to the source of the infection, pathogenic E. coli can be classified as intestinal (diarrheagenic) and extraintestinal (ExPEC). Uropathogenic E. coli (UPEC) is the most…
Bioconductor – marr
DOI: 10.18129/B9.bioc.marr Maximum rank reproducibility Bioconductor version: Release (3.13) marr (Maximum Rank Reproducibility) is a nonparametric approach that detects reproducible signals using a maximal rank statistic for high-dimensional biological data. In this R package, we implement functions that measures the reproducibility of features per sample pair and sample…