Tag: MD

WHO. World Malaria Report. Geneva: World Health Organization; 2019. Google Scholar  Rogerson SJ, Hviid L, Duffy PE, Leke RF, Taylor DW. Malaria in pregnancy: pathogenesis and immunity. Lancet Infect Dis. 2007;7:105–17. Article  CAS  PubMed  Google Scholar  Salanti A, Dahlback M, Turner L, Nielsen MA, Barfod L, Magistrado P, et al….

Hi, running Rsubread 2.8.2/2.12.0 or featureCounts 2.0.3/2.0.1, I stumbled over two issues when allowing ambiguous read assignment (-O/allowMultiOverlap) 1) regarding assignment via minimum fractional overlap (–fracOverlap) using featureCounts stand-alone binary. 2) when combined with –/largestOverlap and –/fraction using Rsubread featureCounts function or the stand-alone binary. to 1) Assume a read…

Oral and Poster Abstracts 626. Aggressive Lymphomas: Prospective Therapeutic Trials: Poster III Research, clinical trials, Lymphomas, Clinical Research, Combination therapy, Diseases, aggressive lymphoma, Therapies, Lymphoid Malignancies Andrew J Davies, BSc, BM, FRCP, PhD1,2*, Josh Caddy, BSc3*, Katy McLaughlin, BSc3*, Christopher Wignall, MSc3*, Robert…

Caribou Biosciences will soon start testing its new CAR T-cell therapy candidate, CB-011, in people with relapsed or refractory multiple myeloma. A Phase 1 trial will begin enrolling eligible adults in early 2023 at multiple centers, according to the company. The announcement follows clearance of the company’s investigational new drug…

November 22, 2022 2 min read Source/Disclosures Published by: Source: Kinslow CJ, et al. JAMA Netw Open. 2022;doi:10.1001/jamanetworkopen.2022.43396. Disclosures: Kinslow reports no relevant financial disclosures. Please see the study for all other authors’ relevant financial disclosures. ADD TOPIC TO EMAIL ALERTS Receive an email when new articles are posted on…

HAS the BBC’s complaints system finally come up against a foe that won’t be put off? A brief history of complaints about the travesty of a BBC documentary, Unvaccinated, proudly promoted in July, suggests it may well have.  The programme, presented by Professor Hannah Fry, signalled its bias from the start. Tom Coveney,…

Bioinformatics Analyst II Job ID: req3154Employee Type: exempt full-timeDivision: Applied & Development Research ProgramFacility: Frederick: Ft DetrickLocation: PO Box B, Frederick, MD 21702 USA The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical…

The University of Texas MD Anderson Cancer Center in Houston is one of the world’s most respected centers focused on cancer patient care, research, education and prevention. It was named the nation’s No. 1 hospital for cancer care in U.S. News & World Report’s 2022 rankings. It is one of…

LOUISVILLE, Ky. — The future medical promise of CRISPR/Cas9 gene-editing appears to be a present-day reality for a small group of patients with the rare genetic condition known as hereditary angioedema (HAE). Interim results reported here from a phase I/II study involving 10 HAE patients showed a single infusion of…

The Immunology department at MD Anderson Cancer Center seeks to determine the fundamental cellular and molecular mechanisms of a wide range of processes by which the body recognizes and eliminates pathogens and use these findings to unleash the patient’s own immune system against previously treatment-resistant cancers. Treating the immune system…

The lab of professor Moradigaravand at KAUST has an opening for one postdoctoral fellowship in Bioinformatics (postdoc.kaust.edu.sa), as part of the KAUST Smart Health Initiative, to investigate the genetic basis of key clinical features of bacterial infections. This position suits recent PhDs, MD/PhDs, with a career interest in computational biology,…

At Cedars-Sinai,postdoctoral scientists and other junior researchers fulfill a critical role inexpanding the horizons of medical knowledge through biomedical research. Byhosting more than 100 postdocs, who conduct vital research and receive advancedtraining with expert faculty mentors, Cedars-Sinai supports theongoing medical education process that continues beyond PhD/MD graduation.   Overview: Bioinformaticsand Integrative Genomics  …

New treatments are emerging for patients with relapsed/refractory diffuse large B-cell lymphoma in addition to chimeric antigen receptor T-cell therapy, which has moved up into the second line. New treatments are emerging for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) in addition to chimeric antigen receptor (CAR) T-cell therapy,…

First Pediatric Study to Evaluate Use of AlloSure dd-cfDNA as Biomarker for Allograft BK Infection Findings Add to Growing Body of Evidence Showing Clinical Value of AlloSure for Surveillance in Pediatric Kidney Transplant Patients BRISBANE, Calif.–(BUSINESS WIRE)– CareDx, Inc. (Nasdaq: CDNA) – The Transplant Company™ focused on the discovery, development, and…

Patients with breast implants are at risk of developing squamous cell carcinoma (SCC) and various types of lymphoma in the capsules around the implants, according to the US Food and Drug Administration (FDA).1  These cancers appear to be rare, but patients and clinicians should be aware of the risk, according…

Woolhouse MEJ, Gowtage-Sequeria S. Host range and emerging and reemerging pathogens. Emerg Infect Dis. 2005;11:1842–7. Article  PubMed  PubMed Central  Google Scholar  Allen T, Murray KA, Zambrana-Torrelio C, Morse SS, Rondinini C, Di Marco M, et al. Global hotspots and correlates of emerging zoonotic diseases. Nat Commun. 2017;8:1–10. Article  CAS  Google…

Ethics statement All procedures involving laboratory mice were approved by the Duke University IACUC under the protocol numbers A189-18-08 and A142-21-07. Mice were housed with up to five mice per cage and the ambient room conditions ranged from 70–74 °F and 30–70% humidity with a 12-hour dark/light cycle. Animals were assessed…

A blood-based multicancer early detection (MCED) test using cell-free DNA (cfDNA) is feasible for outpatients and has a positive predictive value of about 40%, according to a study presented at the 2022 annual meeting of the European Society for Medical Oncology. Deb Schrag, MD, MPH, and colleagues examined the clinical…

Patients with CD5-positive relapsed/refractory peripheral T-cell lymphoma may derive benefit from MT-101, which was granted fast track designation by the FDA. The FDA has granted fast track designation to MT-101 for the treatment of patients with CD5-positive relapsed/refractory peripheral T-cell lymphoma (PTCL), according to a press release from Myeloid Therapeutics….

Zachos FE. Species concepts in biology: historical development, theoretical foundations and practical relevance. Berlin: Springer; 2016. Google Scholar  Perkins SL. Species concepts and malaria parasites: detecting a cryptic species of Plasmodium. Proc Biol Sci. 2000;267:2345–50. CAS  PubMed  PubMed Central  Google Scholar  Mayr E. Systematics and the origin of species. New…

DALLAS, Oct. 25, 2022 /PRNewswire/ — Almaden Genomics has launched g.nome™, a cloud-native platform designed to streamline genomic workflows and accelerate genomic discovery. Leveraging an advanced visual drag-and-drop workflow builder and curated library of toolkits, g.nome enables users to have confidence in their results, get to market faster and…

Animals and immunizations The study protocol and all veterinarian procedures were approved by the Bioqual IACUC per a memorandum of understanding with the Duke IACUC, and were performed based on standard operating procedures. Macaques studied were housed and maintained in an Association for Assessment and Accreditation of Laboratory Animal Care-accredited…

The Department of Biomedical Informatics at Harvard Medical School invites applications for a tenure-track faculty position at the rank of Assistant Professor. Founded in 2015, the Department consists of 16 core faculty members working in diverse areas of biomedical informatics and offers unparalleled opportunities for collaborative research with investigators in…

Credit: Circulation Research (2022). DOI: 10.1161/CIRCRESAHA.121.320625 Researchers at Vanderbilt University Medical Center have found that the change in a single letter of the genetic code promotes, in a mouse model, the development of inflammation, high blood pressure and resulting kidney damage. Their findings, featured Oct. 14 on the cover of…

Prime Medicine, the developer of a “search and replace” gene editing platform, has launched an upsized initial public offering (IPO) that raised $175 million in gross proceeds—about $24 million more than projected just last week. Prime finished its first day of trading at $15.37—nearly 10% below its IPO price of…

October 20, 2022 – A group of Croatian doctors from the Sestre Milosrdnice Clinical Hospital performed the procedure called “irreversible electroporation” (IRE) on two patients for the first time in this region. Luka Novosel, MD and his team of physicians performed the procedure on two patients with liver cancers with…

A survival benefit was elicited with the use of pemigatinib when used for patients with previously treated advanced cholangiocarcinoma who had an FGFR2 fusion or rearrangement. Pemigatinib (Pemazyre) showed a strong survival benefit in patients with previously treated advanced cholangiocarcinoma who had an FGFR2 fusion or rearrangement, according to final…

Hi, I’m ressearching the nanostructure of 2D materials throug in situ transmission electron microscopy.Currently, an interesting structure came out while performing the in situ nanomehcanical testing on a two-dimensional material inside TEM, and I am trying to reproduce the interesting structure through LAMMPS. Since I’m a beginner here, I’ll write…

mike October 14, 2022, 1:29am #1 GROMACS version: 2022.3GROMACS modification: Yes/NoHere post your question I am performing a protein-protein MD simulation, however I am running into an issue such as listed below, where it says “Protein” I can’t distinguish between the two proteins being docked. How would I create an…

Credit: Design Cells/Getty Images Non-profit health system ChristianaCare, with hospitals and health facilities in Delaware, Maryland, Pennsylvania, New Jersey, announced today that it has spun out CorriXR Therapeutics, a biotechnology company that will leverage CRISPR gene editing technology to develop oncology therapeutics, with an initial focus on squamous cell carcinoma…

Job Description*** Partial telework allowed in MD or contiguous states*** The University of Maryland, Baltimore (UMB) School of Medicine is now hiring a Bioinformatics Analyst I (BAI) to join the Institute for Genome Sciences, for our Human Disease Ontology Knowledgebase (DO-KB) team. We are looking for an experienced and motivated…

Dosing has begun in LIGHTHOUSE, a Phase 3 clinical trial testing BIIB122 — an experimental inhibitor of LRRK2 being developed by Biogen and Denali Therapeutics — in patients with early-stage Parkinson’s disease. The study (NCT05418673), underway at two clinical sites in Colorado and Florida, is recruiting up to 400 patients…

Updated results from the L-MIND trial show continued efficacy and safety data for the combination of tafasitamab and lenalidomide for patients with relapsed/refractory diffuse large B-cell lymphoma. Tafasitamab-cxix (Monjuvi) plus lenalidomide (Revlimid) showed long-term efficacy in patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who were treated for at…

Langlois JA, Rutland-Brown W, Wald MM. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil. 2006;21:375–8. doi.org/10.1097/00001199-200609000-00001. Article  PubMed  Google Scholar  Cao HQ, Dong ED. An update on spinal cord injury research. Neurosci Bull. 2013;29:94–102. doi.org/10.1007/s12264-012-1277-8. Article  PubMed  Google Scholar  O’Donnell MJ, Xavier D,…

Lisman J, Buzsáki G, Eichenbaum H, Nadel L, Ranganath C, Redish AD. Viewpoints: how the hippocampus contributes to memory, navigation and cognition. Nat Neurosci. 2017;20:1434–47. CAS  PubMed  PubMed Central  Article  Google Scholar  Kim EJ, Pellman B, Kim JJ. Stress effects on the hippocampus: a critical review. Learn Mem. 2015;22:411–6. PubMed …

The CEO of CRISPR Therapeutics AG (NASDAQ: CRSP), Samarth Kulkarni, sold 25,000 shares of the business’s stock on September 28. The shares were sold at an average price of $64.61 for a total transaction cost of $1,615,250.00. As a result of the transaction, the CEO now directly owns 290,279 company…

Broaden your search Refine your search To see more jobs like this, please sign up for Job Alerts Found 1 Employer job Founded at Hangzhou, China in 2018, Westlake University is a new type of non-profit research-oriented university, creating…

Responsibilities Requisition # 20002022A At Cedars-Sinai, postdoctoral scientists and other junior researchers fulfill a critical role in expanding the horizons of medical knowledge through biomedical research. By hosting more than 100 postdocs, who conduct vital research and receive advanced training with expert faculty mentors, Cedars-Sinai supports the ongoing medical education process that continues…

On Sept 8, 2022, the US Food and Drug Administration (FDA) issued a safety communication to highlight reports of squamous cell carcinoma and various lymphomas in the scar tissue, or capsule, that surrounds breast implants. The lymphomas are distinct from breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), which is also…

Financing to fund izokibep Phase 3 development in psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA) through anticipated submission of biologic license applications (BLA) Phase 2 data for izokibep in PsA presented at the 2022 European Alliance of Associations for Rheumatology Congress (EULAR) demonstrated differentiated efficacy across multiple endpoints – including…

Not everyone who completes a life sciences PhD wants to continue working in a laboratory or in research. They may just have grown out of it or found that the work isn’t what they thought it was. Or maybe they still love science and would rather find a different way…

MaxCyte, Inc ROCKVILLE, Md., Sept. 07, 2022 (GLOBE NEWSWIRE) — MaxCyte, Inc., (NASDAQ: MXCT; LSE: MXCT), a leading commercial cell-engineering company focused on providing enabling platform technologies to advance innovative cell-based research as well as next-generation cell therapeutic discovery, development and commercialization, today announced Company management will present at the…

Post by Sana Saeedhi gmx userscan we use truncated octahedron as -bt (box type) in gromacs. The user manual knows the answer. -Justin—================================================== Justin A. Lemkul, Ph.D.Ruth L. Kirschstein NRSA Postdoctoral Fellow Department of Pharmaceutical SciencesSchool of PharmacyHealth Sciences Facility II, Room 629University of Maryland, Baltimore20 Penn St.Baltimore, MD 21201…

Exponential curve fitting in Python matplotlib 0 Dear community, I’m trying to fit an exponential curve without overfitting. Currently, my code uses 3 to 5 parameters for fitting the curve which looks nice but that incurs information cost and overfitting. Could you help me solve this problem where I can…

Introduction Stroke is one of the leading causes of death and disability worldwide, which causes substantial economic and social burdens.1 Ischemic stroke is caused by insufficient blood and oxygen supply to the brain,2 accounting for about 85% of the casualties of stroke patients.3 The concept of treatment for ischemic injury…

Low-grade inflammation seems to be associated with baseline disease in inherited retinal dystrophies (IRDs), according to Christine N. Kay, MD, a surgeon at Vitreoretinal Associates, in Gainesville, Florida. Examples of XX include zonular instability in cataract surgeries resulting in intraocular lens dislocations in retinitis pigmentosa (RP), presence of anterior vitreous…

A female Aedes aegypti  mosquito feeds from a researcher at The Rockefeller University. Credit: © Alex Wild More than a decade ago, Leslie Vosshall, then a relatively new Howard Hughes Medical Institute (HHMI) Investigator, decided to switch from studying innocuous fruit flies to a far deadlier creature—the mosquito. Perhaps her extensive knowledge of…

Ethics statement and patient samples 40 pairs of OC tissues and adjacent tissue samples were collected from patients who were diagnosed with OC and received surgical resection in the Affiliated Hospital of Zunyi Medical University. None of the patients received any anti-cancer treatment before surgery, and all samples were immediately…

Overview Black Canyon Consulting (BCC) in partnership with Medical Science and Computing (MSC) is searching for a C++ Software Developer in Bioinformatics and Big Data to support the National Center for Biotechnology Information (NCBI).  This opportunity is full time and onsite at the NCBI in Bethesda, MD and/or remote work. NCBI,…

Details Posted: 11-Aug-22 Location: Cincinnati, Ohio Salary: Open Categories: Academic / Research Description Computational postdoctoral positions in bioinformatics and epigenomics (computational/experimental) are available at Dr.Yaping Liu’s lab in the Division of Human Genetics. One of the research directions in Dr. Liu’s group is to study single-cell multi-omics data to understand…

Introduction Antimicrobials are the most important and useful therapeutic discovery in the history of medicine. It allows living beings to survive the microbial disease, enhances invasive surgical procedures, ensures animal health, and protects the food chain since 1928 after the discovery of penicillin. However, the indiscriminate use of antibiotics and…

Overview: We are currently searching for a Bioinformatics Scientist to provide support to the National Institutes of Health (NIH). This opportunity is a full-time position with MSC, and it is on-site in Gaithersburg, MD. Duties & Responsibilities: Work independently and collaboratively to develop or optimize procedures that improve the throughput…

GROMACS version: 2021.2GROMACS modification: No Hello all, I am new to GROMACS. I wanted to install it on a grid computer servers supported by the government and I’ve done step by step instructions in the following link (The language of the instructions is in Turkish but you may find the…

Entry Level Bioinformatics Jobs, Job Description for Bioinformatics | Career Trend, 155 entry level bioinformatic jobs available on indeed. com. Apply to data specialist, clinical associate, biostatistician and more! Skip to job postings, search. Today’s top 36 entry level bioinformatics jobs in united states. , careertrend.com, 240 x 360, jpeg,…

Finding a cure for HIV has been extremely difficult, in part because the virus hides from antiretroviral treatments in one of the hardest places to reach: the brain. Scientists at Texas Biomedical Research Institute (Texas Biomed) and Temple University in Philadelphia recently received a $3.9 million grant from National Institutes…

The purpose of a vaccine (MEBPVC in the current context) is to elicit a strong response from the host immune system against a disease (COVID-19) releasing various neutralizing antibodies which continue to stay in the body to protect the host from any repeat infection thenceforth. Toll-like receptors (TLRs) are the…

Most patients with diffuse large B-cell lymphoma (DLBCL) do not experience significant benefit from treatment with autologous stem cell transplantation (ASCT) and better treatment options are currently available for this population, according to a presentation at the Pan Pacific Lymphoma Conference 2022.1 “ASCT is lousy therapy in the modern age,”…

A visualization of the immune engineering process, from structure selection to authentic virus neutralization. Upper left: Analysis of interaction between SARS-CoV-2 and the ACE2 receptor revealed numerous contact residues along the receptor binding motif (RBM) ridgeline. Upper right: Focus was placed on residues comprising the FNCY patch, a conserved site…

Job Description:    We are seeking a post-doctoral associate in the Intelligent Comparative Oncology Lab directed by Dr. Jon Kim in the College of Veterinary Medicine at the University of Florida (UF). Kim lab focuses on developing novel diagnostic and clinical applications in the field of comparative oncology by utilizing…

Details Posted: 13-Jul-22 Location: La Jolla, California Type: Full-time Salary: Open Categories: Academic/Faculty Healthcare Administration Assistant Professor( Ladder Rank/In-Res) Ophthalmology Bioinformatics Research University of California San Diego Application Window Open date: July 11th, 2022 Next review date: Sunday, Aug 14, 2022 at 11:59pm (Pacific Time)Apply by this date to ensure…

By Sanjay Mukundan As the world is moving closer to recuperation after recurrent waves of the Covid-19 pandemic, safety from the infection has become increasingly significant to stay away from any further spread. Though several drugs, therapies, and plasma therapy have been identified and used in emergency purposes for reducing…

Two mouse models commonly used to study sickle cell disease (SCD) are not suitable for testing certain gene editing treatment approaches, including those for fetal hemoglobin production, because of their specific genetic makeup, a study reported. “This work provides a reminder for scientists to carefully consider the genetics of the…

Postdoctoral Position in Statistical Genetics/Bioinformatics/Epigenetics   Health Disparities Research Section of the Laboratory of Epidemiology and Population Science National Institute on Aging (NIA) National Institute of Health (NIH)   A fully funded postdoctoral position is available immediately in the Health Disparities Research Section of the Laboratory of Epidemiology and Population…

Three doctors have filed a complaint against social media company Twitter, which suspended their accounts on the grounds that they had posted misleading information about COVID-19 vaccines. On behalf of the three physicians, their attorneys filed the complaint on June 26 against the social media company for permanently suspending their…

AlphaFold: The making of a scientific breakthrough The inside story of the DeepMind team of scientists and engineers who created AlphaFold, an AI system that is recognised as a solution to “protein folding”, a grand scientific challenge for more than 50…

Summary An open position for a Postdoctoral Fellow in human molecular genetics/genomics field is available in the laboratory of Rinki Ratnapriya, Ph.D. at the Department of Ophthalmology, Baylor College of Medicine, Houston, TX. The Ratnapriya lab focuses on harnessing the power of genomic technologies to address translational and clinical bioinformatic…

Open Rank Bioinformatics Software Engineer I and Bioinformatics Software Engineer II The Institute for Genome Sciences (IGS), Informatics Resource Center, is recruiting for a Open Rank Bioinformatics Software Engineer I and Bioinformatics Software Engineer II position. This position will be filled as either the Bioinformatics Software Engineer I or II.IGS…

Hello,The official Jupyterhub documentation mentions <hub_url> and<hub_ip> in the proxy settings section: jupyterhub/troubleshooting.md at 95de2618a3e021d5f78434969fd70ff10859d372 · jupyterhub/jupyterhub · GitHub. What these <hub_url> and <hub_ip> exactly are? <hub_ip> is the IP of hub service, hub pod or something else? if I use e.g. domain “my-domain com”, then <hub_url> is “my-domain com/hub”?…

Mokomane M, Kasvosve I, Melo Ed, Pernica JM, Goldfarb DM. The global problem of childhood diarrhoeal diseases: emerging strategies in prevention and management. Ther Adv Infect Dis. 2018;5(1):29–43. PubMed  Google Scholar  Organization WH. Rotavirus vaccines: WHO position paper–July 2021. Weekly Epidemiol Rec. 2021;96(28):301–219. Google Scholar  Bucardo F, Reyes Y, Svensson…

T.Dem June 25, 2022, 5:41pm #1 Dear LAMMPS users, I am trying to run Monte Carlo simulations using reaxff to study the oxygen coverage on a Pt nanoparticle. I defined my oxygen reservoir using the chemical potential definition for a perfect gas. Initially, the system is very small (350 atoms)…

Introduction Tramadol (brand names ConZip, Ultram, UltramER, Odolo) is an analgesic used to treat moderate to severe pain. It is used for a variety of pain conditions, including post-operative pain, cancer pain, and musculoskeletal pain. Tramadol is a centrally acting opioid analgesic with mu-opioid binding activity as well as weak…

By Matthew StengerPosted: 6/13/2022 10:50:00 AM Last Updated: 6/13/2022 10:00:21 AM In a study presented at the 2022 ASCO Annual Meeting (Abstract 10502) and simultaneously published in JCO Precision Oncology, Veda N. Giri, MD, and colleagues found that Black men with prostate cancer exhibited a lower frequency and narrower spectrum…

FibroGen has completed patient enrollment for its Phase 3 trial evaluating pamrevlumab in combination with corticosteroids as a potential treatment for children with Duchenne muscular dystrophy (DMD). The LELANTOS-2 study (NCT04632940) has enrolled 73 boys with DMD, ages 6 to 12, who maintain their ability to walk. The trial, the second…

Introduction Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with an increasing global incidence, and a leading cause of cancer-related mortality.1 Although hepatitis B and C virus infections, cirrhosis, alcohol intake, and non-alcoholic fatty liver disease (NAFLD) are the main risk factors contributing to HCC.1,2 Approximately…

Researchers at The University of Texas MD Anderson Cancer Center have developed an ultrasound-guided cancer immunotherapy platform that generates systemic antitumor immunity and improves the therapeutic efficacy of immune checkpoint blockade. The findings from the preclinical study were published today in Nature Nanotechnology. As the first-of-its-kind platform, the Microbubble-assisted UltraSound-guided…

Good day to all,I am trying to apply Monte Carlo method within the intervals of MD simulation.Specifically, I am trying to write python code that could be invoked from lammps(or vice versa) so that I could add a new calculation method. To begin with, I am currently running Lammps on…

Porting GROMACS Across Heterogeneous Architectures In this second episode about GROMACS, one of the world’s most widely used open source molecular dynamics (MD) applications, we explore the quest to simplify portable, performant programming with Erik Lindahl, Biophysics Professor at Stockholm University & KTH Royal Institute of Technology, and Roland Schulz,…

A group of researchers at Children’s Hospital of Philadelphia (CHOP), in collaboration with Beam Therapeutics, have tested and developed an “off-the-shelf” chimeric antigen receptor T-cell (CART) using base editing, which is designed to allow for precise editing of the CART with less risk of unwanted and unforeseen outcomes that may…

GROMACS version: 2018.3GROMACS modification: No Hi, I am trying to simulate a polymer-water system where the polymer beads interact by Weeks-Chandler-Andersen potential and all the other non-bonded interactions are LJ type. I have two tabulated potential files: (i) table.xvg (for LJ) and (ii) table_P_P.xvg (for WCA). In the .mdp file…

Introduction Breast cancer (BC) is the most commonly diagnosed cancer in women, and it is the main cause of cancer mortality in women around the world.1 Although standard treatments for breast cancer, including surgery, radiotherapy, chemotherapy, endocrine therapy, targeted therapy, and immunotherapy, have greatly improved during the last few decades.2,3…

Hi I have a question on how to deal with following experimental setup. I have data on microbiome and metabolomics for twins that are either MZ or DZ, and thus we have only pairs in the dataset. I would like to assume the twins are unrelated, to be generalizable to…

Normal cells (red) survive much longer than Set1A-mutant cells (green) when ING5 is deleted. Northwestern Medicine scientists have identified critical regulatory processes that govern differentiation in embryonic stem cells, according to a study published in the Proceedings of the National Academy of the Sciences (PNAS). Bercin Cenik, MD, PhD, postdoctoral…

The first patient has been dosed in the phase 1 KN-4802 trial (NCT05242822) examining the safety, tolerability, and preliminary efficacy of KIN-3248, a next-generation pan-FGFR inhibitor, in adult patients with advanced tumors harboring FGFR2 and/or FGFR3 gene alterations, according to a press release from Kinnate Biopharma Inc.1 KIN-3248 is an…

Targeting E. coli DNA pol I to DSBs increased the ratio of 1-bp deletions versus >1-bp deletions and TIS versus non-TIS. (A) Counteracting DNA resection (e.g. MRE11) by pol I fused to Cas9. The expected result is suppression of the MMEJ and SSA DNA repair pathways, which require DNA resection. (B)…

Introduction Liver hepatocellular carcinoma (LIHC) is the most common type of primary cancer in the liver and third leading cause of cancer-related mortality worldwide (1). Although substantial improvements have been made in LIHC therapy, particularly in molecular targeted therapy and immunotherapy (2, 3), the 5-year survival rate of LIHC is…

Yale Cancer Center (YCC) will hold its Fifth Annual Trainee Colloquium virtually on Friday, June 10, 2022 from 8:30am – 1:15pm. This will be a forum for Yale trainees to highlight their research, exchange ideas, and initiate collaborations. We invite predoctoral MD, PhD, MD-PhD students, postdoctoral associates, postdoctoral fellows, residents,…

Details Posted: 26-Apr-22 Location: Nationwide Type: Full-time Salary: Open Internal Number: 20002022 At Cedars-Sinai, postdoctoral scientists and other junior researchers fulfill a critical role in expanding the horizons of medical knowledge through biomedical research. By hosting more than 100 postdocs, who conduct vital research and receive advanced training with expert…

Description Job Description: The Government Health and Safety Solutions Group within the Health group has an opening for a  Biomedical/Bioinformatics Intern. The intern will work alongside data scientists and managers and use biomedical or genomics data to inform health-related research questions. Primary Responsibilities: Under the guidance of Leidos staff, the…

Investigators have characterized the adverse reactions (ARs) resulting from the use of lenvatinib plus pembrolizumab in patients with advanced renal cell carcinoma (aRCC) as well as how these ARs were managed. “Clinicians play a critical role in the prompt identification and management of ARs in patients with aRCC treated with…

Introduction Endometriosis (EMS) is a chronic gynecological disease defined as implantation and periodic growth of the endometrial glands and stroma outside the uterine cavity, causing chronic pelvic pain, severe dysmenorrhea, and infertility in 10% reproductive-age women, among which the infertility rate is approximately 30–50%.1,2 Surgical excision is commonly used for…

CareDx, Inc. Data Highlights Clinical Utility of CareDx Solutions, Including Findings from Surveillance HeartCare Outcomes Registry (SHORE) Demonstrating Power of Multimodality Assessment for More Precise Interventions CareDx Symposia Feature Latest Advancements Including XenoSure and XenoMap SOUTH SAN FRANCISCO, Calif., April 20, 2022 (GLOBE NEWSWIRE) — CareDx, Inc. (Nasdaq: CDNA) –…

Bordeaux, France / April 19th, 2022 – TreeFrog Therapeutics, a biotechnology company aimed at making safer, more efficient and more affordable cell therapies based on induced pluripotent stem cells (iPSCs), today announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell…

Song Y, Zhang Y, Han Z, Xu W, Xiao J, Wang X, et al. Genetic recombination in fast-spreading coxsackievirus A6 variants: a potential role in evolution and pathogenicity. Virus Evol. 2020;6:2. doi.org/10.1093/ve/veaa048. Article  Google Scholar  Chen J, Han Z, Wu H, Xu W, Yu D, Zhang Y. A large-scale outbreak…

Hi! I’m a chemistry undergrad. For my research, I performed docking using Autodock Vina. For further validation, I tried docking using SwissDock too. But now, the two programs give different results. They predict different ligands to give the most favorable binding. I read that Autodock is more reliable. So, should…

Anaveon – ANV419 is very well-tolerated and demonstrates exceptional safety with strong pharmacodynamic effects and excellent IL-2Rβγ selectivity – – A Phase II program of ANV419 has been initiated in multiple tumor types, including melanoma, alongside multiple combination trials – BASEL, Switzerland, April 08, 2022 (GLOBE NEWSWIRE) — Anaveon, a…

Covalent menin inhibitor BMF-219 showed strong cytotoxic activity as a single agent at similar concentrations across multiple preclinical patient derived (PDX) models ex vivo, including diffuse large B-cell lymphoma (DLBCL), multiple myeloma (MM), colorectal cancer (CRC), non-small cell lung cancer (NSCLC), and pancreatic cancer Single agent BMF-219 demonstrated pronounced anti-cancer activity…

Job Description Summary The Section of Epidemiology and Population Sciences at Baylor College of Medicine invites applications for postdoctoral research in systems epidemiology of cancer.  This is a 3-year flexible program with personalized educational curricula and individually tailored multidisciplinary teams of mentors with ongoing research in a variety of pediatric…

image: Monkey iPSCs with edited CCR5 locus growing in culture. view more  Credit: Image Credit: Saritha D’Souza, Wisconsin National Primate Research Center, USA Genetic engineering can make immune cells resistant to infection with human or monkey (simian) immunodeficiency virus (HIV and SIV, respectively). Recently, treatment with HIV-resistant immune cells has given…

How to edit a SAM file using pysam 0 Dear all – I have a template sam file and I want to change one of the columns (template_length) and replace it with a new value. The new value is a quick mathematical operation. template sam file: @HD VN:1.0 SO:unsorted @SQ…

Summary: I’m trying to get a series of pairwise comparisons of specific experimental variables while holding the other variables constant, and can’t figure out how to do it in DESeq2 I am running an circadian experiment with multiple disease states and experimental interventions, let’s say condition: high fat (HFC), normal…