Tag: medulloblastoma
DESeq2 on multilevel design variable
Hello, I am working with RNA-seq data and using DESeq2 to perform differential expression analysis. My design has a single factor, diagnosis, which is a multi-level factor with six different diagnoses: ‘Craniopharyngioma’, ‘ATRT’, ‘Ependymoma’, ‘Glioblastoma’, ‘Glioma’, and ‘Medulloblastoma’. My design is as follows: dds <- DESeqDataSetFromMatrix(countData = count_data, colData =…
Owens Foundation awards projects for cancer and Alzheimer’s research
The William and Ella Owens Medical Research Foundation is awarding $1.5 million to UT Health San Antonio to support research projects that address brain cancers, pancreatic cancers, Alzheimer’s disease and childhood cancers. This year, the foundation will fund eight research projects from UT Health San Antonio investigators. This year’s…
Updates to NCCN Guidelines for CNS Cancers Pinpoint the Importance of Testing
Updated guidelines from the National Comprehensive Cancer Network (NCCN) underscore the importance of molecular and genetic testing for patients with central nervous system (CNS) cancers. This testing provides diagnostic and prognostic information that allows oncologists to administered individualized treatment.1 These updates focus on the management of the numerous CNS cancers,…
Five recent advancements in brain tumor research
In 2023, it is estimated that 24,810 adults in the U.S. will be diagnosed with a primary malignant tumor of the brain and spinal cord. There is currently no cure for brain tumors and current treatment options are mostly limited to surgery, radiation therapy and chemotherapy. However, there is a…
The secrets of the human genome: researchers uncover clues
Humans have only just scratched the surface when it comes to understanding our genome. The massive new Zoonomia project, however, has revealed the importance of studying the genomes of other mammals, such as bumblebee bats, cheetahs and hippos, in order to better understand our own. By comparing the DNA of…
Bats, Cheetahs and Hippos Unlock Mysteries of the Human Genome
Comment on this storyComment Humans like to think we have a monopoly on understanding ourselves — that explanations for all our inner workings, including when things go awry, lie within our genetic code. We might like to think that, but we’re wrong. Whether it’s the diminutive bumblebee bat, the lightning-fast cheetah…
How 240 Mammal Species Help Explain Human Disease Risks
A significant international study examining the genomes of 240 mammals has revealed over three million key regulatory elements, advancing understanding of mammalian evolution, species-specific traits, disease predispositions, and risk of extinction. The findings, which could improve understanding and treatment of diseases like schizophrenia, asthma, and medulloblastoma, underscore that at least…
Ambitious genome project shows how humans fit with other mammals
Scientists on Thursday unveiled the results of a project comparing the genomes of 240 mammal species – from aardvarks and aye-ayes to zebus and zebras, as well as people – to trace evolutionary changes spanning 100 million years, pinpointing genetic traits widely shared and those more uniquely human. The findings…
A Genomic Odyssey Across 240 Mammalian Species Explains Human Disease Risks and More
The Zoonomia Project has documented the genetic diversity in 240 mammalian species, covering over 80% of mammalian families. By sequencing and aligning the genomes, the team has identified conserved genomic regions across species, highlighting areas that may be biologically significant, but do not code for proteins. Their research suggests that…
ALT Plays Role in Treating CNS Tumors: CHOP Studies
Kristina A. Cole, MD, PhD Two recent papers from researchers in the Children’s Hospital of Philadelphia (CHOP) Cancer Center have advanced the understanding of treatment-resistant pediatric tumors, both in assessing a novel treatment and in characterizing the role of alternative lengthening of telomeres (ALT) in these refractory tumors. The first…
A New, Broader Genomic View
Instead of just piecing together short bits of a genome through short-read genomic sequencing, EMBL researchers used long-read nanopore sequencing to gain a more comprehensive understanding of DNA mutation connected to a cancer genome. Credit: Joana Gomes Campos de Carvalho/EMBL Researchers seeking to gain deeper insights into the relationship between…
Medulloblastoma Long-Read Sequences Reveal Complex Rearrangements, Methylation Changes
NEW YORK – With long-read genome sequencing on pre- and post-treatment samples from a childhood brain tumor type called medulloblastoma, a research team from the European Molecular Biology Laboratory (EMBL), the German Cancer Research Center (DFKZ), and elsewhere tracked down new tumor rearrangement and epigenetic patterns that subsequently turned up…
Fat-burning molecule may be promising target
FOR IMMEDIATE RELEASE Research from Johns Hopkins Kimmel Cancer Center experts revealed a type of RNA, previously considered to be “junk,” that may help doctors distinguish and treat a subgroup of patients with medulloblastoma. Medulloblastoma is the most common malignant brain tumor in children, accounting for about 20% of all…
FLI1 and FRA1 transcription factors drive the transcriptional regulatory networks characterizing muscle invasive bladder cancer
Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249 (2021). Article PubMed Google Scholar Sanli, O. et al. Bladder cancer. Nat. Rev. Dis. Prim. 3, 17022 (2017). Article PubMed Google Scholar International…
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress
doi: 10.1038/s41375-023-01853-9. Online ahead of print. Nancy Issa 1 , Hassan Bjeije 1 , Elisabeth R Wilson 1 , Aishwarya Krishnan 1 , Wangisa M B Dunuwille 1 , Tyler M Parsons 1 , Christine R Zhang 1 , Wentao Han 1 , Andrew L Young 1 , Zhizhong Ren 2 , Kai Ge 2 , Eunice S Wang 3 , Andrew…
Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis
Wang, J., Garancher, A., Ramaswamy, V. & Wechsler-Reya, R. J. Medulloblastoma: from molecular subgroups to molecular targeted therapies. Annu. Rev. Neurosci. 41, 207–232 (2018). Article CAS PubMed Google Scholar Cavalli, F. M. G. et al. Intertumoral heterogeneity within medulloblastoma subgroups. Cancer Cell 31, 737–754.e736 (2017). Article CAS PubMed PubMed Central …
Specific stem cell protein found to be involved in the recurrence of medulloblastoma
The malignant brain tumor type medulloblastoma can become resistant to therapy which can cause relapse. Researchers at Uppsala University have discovered a certain protein that makes tumor cells resting and insensitive to radiation treatment. The research group hopes that the results could eventually lead to better treatments for children that…
Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma | BioMedical Engineering OnLine
1. Castle JT. Cholesteatoma pearls: practical points and update. Head Neck Pathol. 2018;12(3):419–29. Article Google Scholar 2. Xie S, Wang X, Ren J, Liu W. The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma. Eur Arch Otorhinolaryngol. 2017;274(5):2071–8. Article Google Scholar 3. Bhutta MF, Williamson IG,…
Bioconductor – MethPed
This package is for version 3.4 of Bioconductor; for the stable, up-to-date release version, see MethPed. A DNA methylation classifier tool for the identification of pediatric brain tumor subtypes Bioconductor version: 3.4 Classification of pediatric tumors into biologically defined subtypes is challenging and multifaceted approaches are needed. For…
