Tag: medulloblastoma

The total operating revenues amounted to $11.9M and increased by 42% compared to Q3 2022. Updated data from Phase Ib study of RVU120 in AML/HR-MDS to be presented at the upcoming American Society of Hematology (ASH) Annual Meeting in December. Preparations for executing Phase II clinical trials of RVU120 in…

Postdoctoral Position – Institut Curie Paris The Genomics and Development of Childhood Cancers lab (institut-curie.org/team/saulnier), headed by Olivier Saulnier is looking for one postdoctoral position researcher in bioinformatics. The team focuses on using cutting-edge high-throughput genomic approaches and genome-wide data analyses to study the spatio-temporal origins of pediatric brain tumors….

Abstract The retina has diverse neuronal cell types derived from a common pool of retinal progenitors. Many molecular drivers, mostly transcription factors, have been identified to promote different cell fates. In Drosophila, atonal is required for specifying photoreceptors. In mice, there are two closely related atonal homologs, Atoh1 and Atoh7….

Zack TI, Schumacher SE, Carter SL, Cherniack AD, Saksena G, Tabak B, Lawrence MS, Zhang C-Z, Wala J, Mermel CH. Pan-cancer patterns of somatic copy number alteration. Nat Genet. 2013;45:1134–40. Article  CAS  PubMed  PubMed Central  Google Scholar  Dixon JR, Xu J, Dileep V, Zhan Y, Song F, Le VT, Yardımcı…

Runners are a persistent bunch with goals to conquer and PRs to smash. That could explain why so many runners have stories of when they experienced an ache, kept running through it, and then ended up with an injury that put them on the sidelines for months. A better approach…

The veil on genetic information was lifted by the advent of gene cloning and sequencing technologies in the 1970s. The discovery and purification of bacterial nucleases capable of cutting DNA at specific sequences and ligases capable of joining them enabled DNA from any species – or mRNAs converted to complementary…

Data simulation Short nanopore sequencing runs yield sparse and random coverage of the genome. To enable model training, we generate simulated sparse nanopore runs based on microarray data. To this end, N simulated reads are randomly sampled from the read length distribution (D) and assigned a start mapping position in…

Patient characteristics and PDX establishment Between February 2016 and July 2020, 787 pediatric, adolescent and young adult patients with recurrent or refractory malignancies were enrolled in the MAPPYACTS trial;2 756 (96%) patients and their parents consented to the optional ancillary study of preclinical model development (Fig. 1a). 744 patients had a…

Lukas Chavez, Ph.D., has received $3.2 million from the National Institutes of Health to study how unique DNA circles found in cancer cells drive deadly pediatric brain tumors. The research aims to expose how the circular pieces of DNA contribute to therapy resistance and open new therapeutic avenues to improve…

The MYCC and MYCN loci are each associated with two upstream open reading frames (uORFs) potentially encoding small proteins (9-21 kDa). We previously demonstrated that uORFs mrtl and MYCHEX1 of MYCC are translated, and their protein products may function to regulate the expression of the “parent” oncogene. We hypothesized that…

Robert McCabe of Anchorage, Alaska, is a 15-year-old avid bowler, a fan of baseball and basketball, and a rising high school sophomore who hopes to be an engineer one day. He is also a pediatric cancer survivor, and most recently, a pediatric cancer researcher. This summer, he helped to sequence…

Robert McCabe of Anchorage, Alaska, is a 15-year-old avid bowler, a fan of baseball and basketball, and a rising high school sophomore who hopes to be an engineer one day. He is also a pediatric cancer survivor, and most recently, a pediatric cancer researcher. This summer, he helped to sequence…

Based on this case, we raised the question of whether there might be a connection between pathogenic mtDNA variants and MB occurrence or phenotype. We analysed mtDNA variants in MB, employing whole-genome sequencing data of 491 patients from the ICGC cohort and 57 formalin-fixed paraffin-embedded human G3/G4 MB tumour samples…

Craig Horbinski, MD, PhD, director of neuropathology in the Department of Pathology, professor of pathology, neurological surgery, and neuropathology, Feinberg School of Medicine at Northwestern University, discusses the classification of gliomas based on histology and molecular features. The importance of molecular and genetic testing is highlighted in the updated guidelines…

Hello, I am working with RNA-seq data and using DESeq2 to perform differential expression analysis. My design has a single factor, diagnosis, which is a multi-level factor with six different diagnoses: ‘Craniopharyngioma’, ‘ATRT’, ‘Ependymoma’, ‘Glioblastoma’, ‘Glioma’, and ‘Medulloblastoma’. My design is as follows: dds <- DESeqDataSetFromMatrix(countData = count_data, colData =…

  The William and Ella Owens Medical Research Foundation is awarding $1.5 million to UT Health San Antonio to support research projects that address brain cancers, pancreatic cancers, Alzheimer’s disease and childhood cancers. This year, the foundation will fund eight research projects from UT Health San Antonio investigators. This year’s…

Updated guidelines from the National Comprehensive Cancer Network (NCCN) underscore the importance of molecular and genetic testing for patients with central nervous system (CNS) cancers. This testing provides diagnostic and prognostic information that allows oncologists to administered individualized treatment.1 These updates focus on the management of the numerous CNS cancers,…

In 2023, it is estimated that 24,810 adults in the U.S. will be diagnosed with a primary malignant tumor of the brain and spinal cord. There is currently no cure for brain tumors and current treatment options are mostly limited to surgery, radiation therapy and chemotherapy. However, there is a…

Humans have only just scratched the surface when it comes to understanding our genome. The massive new Zoonomia project, however, has revealed the importance of studying the genomes of other mammals, such as bumblebee bats, cheetahs and hippos, in order to better understand our own. By comparing the DNA of…

Comment on this storyComment Humans like to think we have a monopoly on understanding ourselves — that explanations for all our inner workings, including when things go awry, lie within our genetic code. We might like to think that, but we’re wrong. Whether it’s the diminutive bumblebee bat, the lightning-fast cheetah…

A significant international study examining the genomes of 240 mammals has revealed over three million key regulatory elements, advancing understanding of mammalian evolution, species-specific traits, disease predispositions, and risk of extinction. The findings, which could improve understanding and treatment of diseases like schizophrenia, asthma, and medulloblastoma, underscore that at least…

Scientists on Thursday unveiled the results of a project comparing the genomes of 240 mammal species – from aardvarks and aye-ayes to zebus and zebras, as well as people – to trace evolutionary changes spanning 100 million years, pinpointing genetic traits widely shared and those more uniquely human. The findings…

The Zoonomia Project has documented the genetic diversity in 240 mammalian species, covering over 80% of mammalian families. By sequencing and aligning the genomes, the team has identified conserved genomic regions across species, highlighting areas that may be biologically significant, but do not code for proteins. Their research suggests that…

Kristina A. Cole, MD, PhD Two recent papers from researchers in the Children’s Hospital of Philadelphia (CHOP) Cancer Center have advanced the understanding of treatment-resistant pediatric tumors, both in assessing a novel treatment and in characterizing the role of alternative lengthening of telomeres (ALT) in these refractory tumors. The first…

Instead of just piecing together short bits of a genome through short-read genomic sequencing, EMBL researchers used long-read nanopore sequencing to gain a more comprehensive understanding of DNA mutation connected to a cancer genome. Credit: Joana Gomes Campos de Carvalho/EMBL Researchers seeking to gain deeper insights into the relationship between…

NEW YORK – With long-read genome sequencing on pre- and post-treatment samples from a childhood brain tumor type called medulloblastoma, a research team from the European Molecular Biology Laboratory (EMBL), the German Cancer Research Center (DFKZ), and elsewhere tracked down new tumor rearrangement and epigenetic patterns that subsequently turned up…

FOR IMMEDIATE RELEASE Research from Johns Hopkins Kimmel Cancer Center experts revealed a type of RNA, previously considered to be “junk,”  that may help doctors distinguish and treat a subgroup of patients with medulloblastoma. Medulloblastoma is the most common malignant brain tumor in children, accounting for about 20% of all…

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doi: 10.1038/s41375-023-01853-9. Online ahead of print. Nancy Issa  1 , Hassan Bjeije  1 , Elisabeth R Wilson  1 , Aishwarya Krishnan  1 , Wangisa M B Dunuwille  1 , Tyler M Parsons  1 , Christine R Zhang  1 , Wentao Han  1 , Andrew L Young  1 , Zhizhong Ren  2 , Kai Ge  2 , Eunice S Wang  3 , Andrew…

Wang, J., Garancher, A., Ramaswamy, V. & Wechsler-Reya, R. J. Medulloblastoma: from molecular subgroups to molecular targeted therapies. Annu. Rev. Neurosci. 41, 207–232 (2018). Article  CAS  PubMed  Google Scholar  Cavalli, F. M. G. et al. Intertumoral heterogeneity within medulloblastoma subgroups. Cancer Cell 31, 737–754.e736 (2017). Article  CAS  PubMed  PubMed Central …

The malignant brain tumor type medulloblastoma can become resistant to therapy which can cause relapse. Researchers at Uppsala University have discovered a certain protein that makes tumor cells resting and insensitive to radiation treatment. The research group hopes that the results could eventually lead to better treatments for children that…

1. Castle JT. Cholesteatoma pearls: practical points and update. Head Neck Pathol. 2018;12(3):419–29. Article  Google Scholar  2. Xie S, Wang X, Ren J, Liu W. The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma. Eur Arch Otorhinolaryngol. 2017;274(5):2071–8. Article  Google Scholar  3. Bhutta MF, Williamson IG,…

    This package is for version 3.4 of Bioconductor; for the stable, up-to-date release version, see MethPed. A DNA methylation classifier tool for the identification of pediatric brain tumor subtypes Bioconductor version: 3.4 Classification of pediatric tumors into biologically defined subtypes is challenging and multifaceted approaches are needed. For…