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Bioinformatics Market Is Set To Reach USD 28.6 Billion By 2030 With CAGR Of 13.73% | Marketdigits
(MENAFN– GlobeNewsWire – Nasdaq) The Global Bioinformatics Market was valued USD 10.23 Billion in 2023 and projected to reach USD 28.6 Billion by 2030, growing at a CAGR of 13.73% during the forecast period of 2023-2030 Richmond, Feb. 09, 2024 (GLOBE NEWSWIRE) — According to a research report ” Bioinformatics…
Bioinformatics Market is Set to Reach USD 28.6 Billion by
Richmond, Feb. 09, 2024 (GLOBE NEWSWIRE) — According to a research report “Bioinformatics Market”, by tools Type (BLAST, BioPerl, InterMine, Others), Services (Genome Sequencing, RNA sequencing, Metagenomic Analysis, Epigenomic, Others), Application (Drug discovery, Personalized medicine, Preventive medicine, Transcriptions, Metabolomics, Gene therapy, Others) Sectors (Medical Biotechnology, Animal Biotechnology, Plant Biotechnology, Environmental…
Boosting Immune Response with Non-Viral Gene Electrotransfer
A groundbreaking study published in Nature Cancer has unveiled a novel approach to tumor treatment. By leveraging local intratumor delivery with electroporation of low levels of plasmids encoding molecules, researchers have discovered an antitumor effect that does not result in systemic toxicity. Upregulating MHC-I and PD-L1: The Keys to Unlocking…
The promising horizon of hair loss treatments
There hasn’t been a lot of hair loss treatment progress in the last twenty years. However several biotech companies are hot on the case and are getting tantalizingly close to the breakthrough that many patients hope for. With body dysmorphia magnified by the omnipresent digital world, psychiatrists have increasingly linked…
The immense challenge of cancer vaccines: ‘There are promising results’ | Science
The dream of a cancer vaccine — capable of stimulating the immune system to fight tumors — is on the horizon of the scientific community. It probably has never been as close as it is now. After years of few successes in this field, the consolidation of other immunotherapies and…
Crispr Library Download
CRISPR guide RNA libraries have been iteratively improved to provide increasingly efficient reagents, although their large size is a barrier for many applications. We design an optimised minimal genome-wide human CRISPR-Cas9 library (MinLibCas9) by mining existing large-scale gene loss-of-function datasets, resulting in a greater than 42% reduction in size compared…
Newly developed computational tools and large datasets with low bias will lead to robust neoantigen prediction and improved personalized cancer therapies
Newly developed computational tools and large datasets with low bias will lead to robust neoantigen prediction and improved personalized cancer therapies LONDON, Dec. 18, 2023 (GLOBE NEWSWIRE) — Achilles Therapeutics plc (NASDAQ: ACHL), a clinical-stage biopharmaceutical company developing AI-powered precision T cell therapies targeting clonal neoantigens to treat solid tumors,…
ASH 2023: CAR T-Cell Therapy Safe, Effective for High-Risk DLBCL Patients
ASH 2023: CAR T-Cell Therapy Safe, Effective for High-Risk DLBCL Patients | PracticeUpdate …
BMS Ends Phase 3 Trial of Nivolumab and Relatlimab in CRC
Colorectal Cancer: © peterschreiber.media – stock.adobe.com Bristol Myers Squibb is ending the phase 3 RELATIVITY-123 trial (NCT05328908) investigating nivolumab (Opdivo) and relatlimab (Opdualag) in patients with previously treated metastatic microsatellite stable (MSS) colorectal cancer (CRC) with disease progression following 1, but no more than 4 lines of therapy, due to…
A Treatment Option for Metastatic Colorectal Cancer Patients with BRAFV600E Mutation in Singapore | Taiwan News
Targeted therapy regimen, BRAFTOVI® (encorafenib) in combination with cetuximab, included on MOH Cancer Drug List, for the treatment of adult patients with BRAFV600E-mutant metastatic colorectal cancer who have received prior systemic therapy. BRAFTOVI in combination with cetuximab has been included on MOH CDL, for patients with BRAFV600E-mutant metastatic colorectal cancer…
Arsenic is a potent co-mutagen of ultraviolet light
Barnes, J. L., Zubair, M., John, K., Poirier, M. C. & Martin, F. L. Carcinogens and DNA damage. Biochem. Soc. Trans. 46, 1213–1224 (2018). Article CAS PubMed PubMed Central Google Scholar Ames, B. N., Durston, W. E., Yamasaki, E. & Lee, F. D. Carcinogens are mutagens: a simple test system…
Gadolinium Oxide Nanoparticles reinforce immune response
Boyi Yu,1– 4 Xuanyi Lu,5 Xianglong Feng,1– 4 Ting Zhao,1– 4 Jiaxin Li,1– 4 Yudie Lu,5 Fei Ye,1– 4 Xiongxiong Liu,1– 4 Xiaogang Zheng,1– 4 Zheyu Shen,5 Xiaodong Jin,1– 4 Weiqiang Chen,1– 4 Qiang Li1– 4 1Biomedical Center, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, People’s Republic of…
Fatty Acid Metabolism-Related lncRNAs as Biomarkers for SKCM
Introduction Skin cutaneous melanoma (SKCM), as one of the most aggressive types of cancer due to its elevated degree of heterogeneity, has gained increasing attention during the past few decades.1 Also known as “the cancer that rises with the sun”,2 melanoma originates from cancerous melanocytes due to molecular or genetic…
Genomic Predictors Associated With Exceptional Response to Systemic Therapy in Advanced Pancreatic Cancer
ABSTRACT Introduction: Exceptional response to therapy is rare in patients with advanced pancreatic cancer. This study explored potential genomic differences between typical and exceptional responses that could confer more favorable biology. Methods: We included exceptional responders and controls with advanced pancreatic cancer from Cleveland Clinic from April 2013 to August…
SOCS3 inhibiting JAK-STAT pathway enhances oncolytic adenovirus efficacy by potentiating viral replication and T-cell activation
Kaufman HL, Kohlhapp FJ, Zloza A. Oncolytic viruses: a new class of immunotherapy drugs. Nat Rev Drug Discov. 2015;14:642–62. Article CAS PubMed PubMed Central Google Scholar Kessler T, Wick W. Oncolytic virotherapy: potentially a game-changing tumor treatment. Cancer Cell. 2021;39:753–5. Article CAS PubMed Google Scholar Koch J, Schober SJ, Hindupur…
Identification of Differentially Expressed Genes in Human Colorectal Cancer Using RNASeq Data Validated on the Molecular Level with Real-Time PCR
Allam RM, Al-Abd AM, Khedr A, Sharaf OA, Nofal SM, Khalifa AE, Mosli HA, Abdel-Naim AB (2018) Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells. Toxicol Lett 291:77–85 Article CAS PubMed Google Scholar Andrews S et al (2010) FastQC: a quality control tool…
Verrica Pharmaceuticals’ Development and Commercialization
WEST CHESTER, Pa., Dec. 15, 2023 (GLOBE NEWSWIRE) — Verrica Pharmaceuticals Inc. (“Verrica” or “the Company”) (Nasdaq: VRCA), a dermatology therapeutics company developing medications for skin diseases requiring medical interventions, today announced that its development and commercialization partner, Torii Pharmaceutical Co., Ltd. (“Torii”), reported positive top-line results from its Phase…
RP1 Plus Cemiplimab Misses Response End Points in Locally Advanced or Metastatic CSCC
Philip Astley-Sparke, chief executive officer of Replimune Group, Inc. The combination of RP1 and cemiplimab-rwlc (Libtayo) provided a numerical, but not statistically significant, improvement in response rates vs cemiplimab alone in patients with locally advanced or metastatic cutaneous squamous cell carcinoma (CSCC), missing the primary end points of the phase…
Morphogenesis, Inc. Announces Corporate Rebranding to TuHURA Biosciences, Inc. and Provides a Business Overview
Company focused on advancing novel personalized cancer vaccines to overcome tumor resistance to immunotherapies like checkpoint inhibitors; and first-in-class bi-functional antibody drug conjugates (ADCs) targeting Myeloid Derived Suppressor Cells (MDSCs) to modulate their immunosuppressive effects on the tumor microenvironment Company on track to initiate pivotal Phase 3 study of lead…
New method tags cells with location coordinates for single-cell studies
Brain cells (each represented by a dot), categorized into seven cell types (each a different color), are spatially mapped in a 10 mm square region of the human prefrontal cortex. Credit: Russell AJC et al., Nature 2023, doi:10.1038/s41586-023-06837-4 When a scientist wants to study individual cells at the molecular level…
The latest on Moderna, Apellis, and Merck
Want to stay on top of the science and politics driving biotech today? Sign up to get our biotech newsletter in your inbox. Hello, everyone. Damian here with the fallout from Pfizer’s downbeat update, a new entrant in obesity research, and an orthogonal CRISPR business. The need-to-know this morning Apellis Pharmaceuticals said a…
‘Gene gun’ aims to make universal flu vaccine possible – UW Medicine
A “gene gun” that blasts DNA directly into cells will be used to test a universal influenza vaccine in a clinical trial slated for next year. The unique vaccine delivery system was developed by Deborah Fuller, a professor of microbiology at the University of Washington School of Medicine. Fuller said…
a beacon of hope in glioblastoma treatment
Glioblastoma is an extremely aggressive type of brain cancer and is the most common type of primary malignant brain tumor in adults. There is currently no cure for it and, due to its fast-growing nature and location, it is very difficult to treat. But could CAR-T cell therapy – which…
Merck and Moderna Initiate INTerpath-002, a Phase 3 Study Evaluating V940 in Combination with KEYTRUDA for Adjuvant Treatment of Patients with Certain Types of Resected Non-Small Cell Lung Cancer -December 12, 2023 at 06:22 am EST
RAHWAY – Merck (NYSE: MRK), known as MSD outside of the United States and Canada, and Moderna, Inc. (Nasdaq: MRNA), today announced the initiation of INTerpath-002, a pivotal Phase 3 randomized clinical trial evaluating V940 (mRNA-4157), an investigational individualized neoantigen therapy (INT), in combination with KEYTRUDA, Merck s anti-PD-1 therapy,…
NX-1607 Is Under Phase 1 Evaluation in DLBCL and Other Advanced Malignancies
NX-1607 in DLBCL | Image Credit: © freshidea – stock.adobe.com The phase 1a/1b NX-1607-101 trial (NCT05107674) will evaluate NX-1607, a CBL-B inhibitor, in patients with advanced malignancies, including diffuse large B-cell lymphoma (DLBCL), according to a poster that was presented during the 2023 ASH Annual Meeting. The dose-escalation portion of…
Construction of a risk stratification model integrating ctDNA to predict response and survival in neoadjuvant-treated breast cancer | BMC Medicine
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. Article PubMed Google Scholar Giaquinto AN, Sung H, Miller KD, Kramer JL, Newman LA,…
Erasca Granted FDA Fast Track Designation for Pan-RAF Inhibitor Naporafenib in Patients with Advanced NRAS-Mutated Melanoma
First-in-class and best-in-class potential in NRAS-mutated melanoma and other RAS/MAPK pathway-altered solid tumors Naporafenib has been dosed in more than 500 patients to date, establishing its safety, tolerability, and preliminary proof-of-concept in multiple indications Pivotal Phase 3 SEACRAFT-2 trial initiation in NRAS-mutated melanoma on track for H1 2024 SAN DIEGO,…
RPTOR mutation: a novel predictor of efficacious immunotherapy in melanoma
Li Z, Gao Y, Cao Y et al (2023) Extracellular RNA in Melanoma: advances, challenges, and opportunities. Front Cell Dev Biol 11:1141543. doi.org/10.3389/fcell.2023.1141543 Article PubMed PubMed Central Google Scholar Hamid O, Cowey CL, Offner M, Faries M, Carvajal RD (2019) Efficacy, Safety, and tolerability of approved combination BRAF and MEK…
Screening for lipid nanoparticles that modulate the immune activity of helper T cells towards enhanced antitumour activity
Huang, Q., Zeng, J. & Yan, J. COVID-19 mRNA vaccines. J. Genet. Genomics 48, 107–114 (2021). Article CAS PubMed PubMed Central Google Scholar Huang, S., Zhu, Y., Zhang, L. & Zhang, Z. Recent advances in delivery systems for genetic and other novel vaccines. Adv. Mater. 34, e2107946 (2022). Article PubMed …
Merck (MRK), Moderna (MRNA) initiate INTerpath-002 Phase 3 trial of V940/KEYTRUDA combo in NSCLC
Merck (NYSE: MRK), known as MSD outside of the United States and Canada, and Moderna, Inc. (Nasdaq: MRNA), today announced the initiation of INTerpath-002, a pivotal Phase 3 randomized clinical trial evaluating V940 (mRNA-4157), an investigational individualized neoantigen therapy (INT), in combination with KEYTRUDA, Merck’s anti-PD-1 therapy, as adjuvant treatment…
Bladder Cancer Pipeline, FDA Approvals, Clinical Trials Developments and Companies 2023
PRESS RELEASE Published December 7, 2023 DelveInsight’s, “Bladder Cancer Pipeline Insight 2023” report provides comprehensive insights about 100+ companies and 100+ pipeline drugs in the Bladder cancer pipeline landscape. It covers the Bladder Cancer pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Bladder Cancer pipeline…
2023-12-08 | NYSE:MRK | Press Release
Merck (NYSE: MRK), known as MSD outside of the United States and Canada, and Eisai today announced that the Phase 3 LEAP-001 trial evaluating KEYTRUDA, Merck’s anti-PD-1 therapy, plus LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, did not meet its dual primary endpoints of overall…
A year in review of ground-breaking life science research Labmate Online
Exploring the frontiers of science with AMSBIO In a recent blog post, AMSBIO reflects on the innovative life science and biomedical research conducted by its customers throughout 2023. From unravelling the complexities of cancer progression mechanisms to transforming wound care, AMSBIO proudly acknowledges its role in supporting these scientific endeavours….
B-Cell Lymphomas Pipeline, FDA Approvals, Clinical Trials Developments and Companies 2023
PRESS RELEASE Published December 7, 2023 DelveInsight’s, “B-Cell Lymphoma Pipeline Insight 2023” report provides comprehensive insights about 160+ companies and 170+ pipeline drugs in B-Cell Lymphoma pipeline landscape. It covers the B-Cell Lymphomas pipeline drug profiles, including clinical and nonclinical stage products. It also covers the B-Cell Lymphomas pipeline therapeutics…
Bristol Myers Squibb Announces Phase 3 CheckMate -8HW Trial Evaluating Opdivo (nivolumab) Plus Yervoy (ipilimumab)
PRINCETON, N.J.–(BUSINESS WIRE)– Bristol Myers Squibb Company Announces Phase 3 CheckMate -8HW Trial Evaluating Opdivo (nivolumab) Plus Yervoy (ipilimumab) Compared to Chemotherapy in Microsatellite Instability–High or Mismatch Repair Deficient Metastatic Colorectal Cancer Meets Primary Endpoint Bristol Myers Squibb (NYSE: BMY) today announced the Phase 3 CheckMate -8HW trial evaluating…
Merck Halts Phase 3 Trial of Keytruda Combination for Non-Small Cell Lung Cancer
Trial of Keytruda (pembrolizumab) plus chemotherapy and maintenance Lynparza (olaparib; AstraZeneca, MSD) for the treatment of metastatic squamous non-small cell lung cancer stopped after data did not show a survival benefit. Merck has announced that it will halt the Phase 3 KEYLYNK-008 trial evaluating Keytruda (pembrolizumab) plus chemotherapy and maintenance Lynparza…
Gene Therapy Market projected to reach USD 38.33 Billion by
Richmond, Dec. 06, 2023 (GLOBE NEWSWIRE) — According to a research report “Gene Therapy Market”, By Technology (Viral Vector-Based Gene Therapy {Adeno-Associated Virus (AAV), Lentivirus, Adenovirus, Retrovirus and Modified Herpes Simplex Virus}, Non-Viral Vectors-Based Gene Therapy {Electroporation, Gene Gun, Liposomes and Naked DNA}, CRISPR/Cas9 Technology), Therapy Type (Acute Lymphoblastic Leukemia…
Key Genes for Pyroptosis-induced Salivary Gland Inflammation
Kaiyuan Zhang,1,* Ziyue Luo,1,* Xinchao Zhu,1 Xinyi Yao,1 Dingqi Lu,2 Liying Chen,1 Tao Hong,1 Yating Ren,1 Xinchang Wang3 1Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China; 2First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, 310053, People’s Republic of China;…
U.S. Food and Drug Administration Accepts for Priority Review Bristol Myers Squibb’s Application for Opdivo (nivolumab) in Combination with Cisplatin-Based Chemotherapy for the First-Line Treatment of Adult Patients with Unresectable or Metastatic…
Application based on results from the Phase 3 CheckMate -901 trial showing significant survival improvement vs. standard-of-care gemcitabine plus cisplatin in cisplatin-eligible patients with untreated, unresectable or metastatic urothelial carcinoma If approved, the Opdivo-based regimen would be the first immunotherapy-chemotherapy combination approved for this patient population in the U.S. The…
Microbial gene expression analysis of healthy and cancerous esophagus uncovers bacterial biomarkers of clinical outcomes
Yang J, Liu X, Cao S, Dong X, Rao S, Cai K. Understanding esophageal cancer: the challenges and opportunities for the next decade. Front Oncol. 2020;10:1727. Article PubMed PubMed Central Google Scholar Li J, Xu J, Zheng Y, Gao Y, He S, Li H, et al. Esophageal cancer: epidemiology, risk…
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes
Kornberg, R. D. & Lorch, Y. Primary role of the nucleosome. Mol. Cell 79, 371–375 (2020). Article CAS PubMed Google Scholar Zhu, F. et al. The interaction landscape between transcription factors and the nucleosome. Nature 562, 76–81 (2018). Article CAS PubMed PubMed Central Google Scholar Lee, C. K., Shibata, Y.,…
Targeting the epigenome to reinvigorate T cells for cancer immunotherapy | Military Medical Research
Tsui C, Kretschmer L, Rapelius S, Gabriel SS, Chisanga D, Knöpper K, et al. MYB orchestrates T cell exhaustion and response to checkpoint inhibition. Nature. 2022;609(7926):354–60. Article CAS PubMed PubMed Central Google Scholar Zhu L, Zhou X, Gu M, Kim J, Li Y, Ko CJ, et al. Dapl1 controls NFATc2…
Laura Zitella Discusses the Growing Arsenal of Bispecific Antibodies in DLBCL
In May 2023, the FDA granted accelerated approval to epcoritamab-bysp (Epkinly) for the treatment of adult patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), including DLBCL arising from indolent lymphoma, and high-grade B-cell lymphoma (HGBL), following 2 or more lines of systemic therapies. Shortly thereafter, in June 2023, the…
Comprehensive analysis of necroptotic patterns and associated immune landscapes in individualized treatment of skin cutaneous melanoma
Identification of the SKCM necroptosis cluster The comprehensive analysis encompassed a total of 803 patients drawn from five distinct melanoma cohorts, namely, TCGA-SKCM, GSE65094, GSE53118, GSE54467, and GSE19234. Employing an unsupervised clustering algorithm, we stratified melanoma patients based on their NRG expression profiles. This facilitated a deeper exploration of the…
Moffitt Innovators of Tomorrow Symposium Welcomes Its First Recruited Postdoc, Dr. Hayley du Bois
Research Education & Training is excited to welcome Dr. Haley du Bois back to campus as a new postdoctoral fellow in the lab of Dr. Conor Lynch. Dr. du Bois first visited campus in May as part of the inaugural cohort of the Moffitt Innovators of Tomorrow (MIOT) Symposium, our newest…
FBXW7 and human tumors: mechanisms of drug resistance and potential therapeutic strategies
Review . 2023 Nov 13:14:1278056. doi: 10.3389/fphar.2023.1278056. eCollection 2023. Affiliations Expand Affiliation 1 Cancer Center, The First Hospital of Jilin University, Changchun, Jilin, China. Free PMC article Item in Clipboard Review Wanqing Wang et al. Front Pharmacol. 2023. Free PMC article Show details Display options Display options Format AbstractPubMedPMID . 2023…
FDA Clears IND for Tumor Infiltrating Lymphocyte Therapy
An investigational new drug (IND) has been accepted by the FDA for KSQ-001EX . KSQ-001Ex is an engineered tumor infiltrating lymphocyte (TIL). A phase 1/2 study will begin with this approval. The FDA has approved an IND application for a phase 1/2 study of KSQ-001EX, an engineered TIL program, according…
FDA Grants Clearance for Phase 1/2 Trial of eTIL KSQ-001EX in Solid Tumors
The FDA has granted clearance for an investigational new drug application for a phase 1/2 safety lead-in trial investigating the engineered tumor-infiltrating lymphocyte (eTIL) KSQ-001EX in patients with melanoma, head and neck squamous cell carcinoma, and non–small cell lung cancer.1 The primary objective of the phase 1 portion of the…
What is iPSC derived regulatory T cells?
How regulatory t cells suppress the immune system?3 answersRegulatory T cells (Tregs) suppress the immune system through various mechanisms. One mechanism involves the suppression of cytotoxic T lymphocyte (CTL) responses, leading to a decrease in the production of cytokines such as IFN-γ and TNF by CD8+ T cells. Tregs also…
What type of cancer did they study in this paper?
What type of cancer did they study in this paper? 1 I am currently reviewing a research paper which focuses on investigating the effects of anti-PD1 drugs in cancer patients, utilizing single-cell RNA sequencing on T-cells. The authors have detailed the process of collecting blood samples, yet they have not…
Refubium – Liquid Biopsy – Blood-based biomarkers for the molecular analysis of cancer
Tissue analysis is the current gold standard for cancer diagnosis and characterization, although it may neither fully represent spatial tumor heterogeneity nor clonal evolution under treatment pressure. The analysis of circulating tumor cells (CTCs) and cell-free DNA (cfDNA) holds great potential to partially overcome this limitation. One major uncertainty is,…
The evolution of drug discovery & development through innovation
Drug discovery and development is a long, costly, and high-risk process that takes over 10 to 15 years with an average cost of over $1 to $2 billion for each new drug to be approved for clinical use. For any pharmaceutical company or academic institution, it is a big achievement…
KSQ Therapeutics Announces FDA Clearance of IND Application
LEXINGTON, Mass., Nov. 29, 2023 (GLOBE NEWSWIRE) — KSQ Therapeutics, Inc. (KSQ), a clinical-stage biotechnology company developing novel treatments for solid tumors, in collaboration with The University of Texas MD Anderson Cancer Center and the Cell Therapy Manufacturing Center (CTMC), today announced the Food and Drug Administration (FDA) has cleared…
Orlance Inc. Awarded NIH SBIR Grant for Next Generation Gene-Gun Delivered DNA and RNA Immunotherapeutic Vaccines for Melanoma
SEATTLE, Nov. 28, 2023 /PRNewswire/ — Orlance, Inc., a Seattle biotech developing next-generation DNA and RNA vaccines and therapeutics, has been awarded a National Institutes of Health (NIH) Phase I Small Business Innovation Research (SBIR) grant to use its needle-free MACH-1™ platform for creating a vaccine regimen that induces strong…
Hidden Immune Defense Against Cancer Uncovered in Study
Researchers at the UCLA Jonsson Comprehensive Cancer Center have found certain immune cells can still fight cancer even when the cancer cells lack an important protein that the immune system relies on to help track down cancer cells. The team discovered the absence of the crucial protein B2M seems to…
Five biotech companies in Texas shaping the state’s hubs
Thanks to the U.S. government’s ambitious plans to advance American biotech and biomanufacturing, Texas’ life sciences hubs, particularly in Dallas and Houston, are now one of many in the country that are currently thriving. In this article, we take a closer look at several biotech companies in Texas taking advantage…
Nutrient found in beef and dairy improves immune response to cancer
Newswise — Trans-vaccenic acid (TVA), a long-chain fatty acid found in meat and dairy products from grazing animals such as cows and sheep, improves the ability of CD8+ T cells to infiltrate tumors and kill cancer cells, according to a new study by researchers from the University of Chicago. The…
A Deep Dive into Trends, Players, and Growth
The gene therapy market has evolved into a juggernaut in the healthcare sector, displaying an extraordinary trajectory of growth. As of 2023, the gene therapy market has surged to a remarkable value of USD 6.36 billion, and the projection for the forthcoming years is nothing short of astonishing. Forecasts indicate…
The pros, cons and concerns
Commensurate with technological improvements and the subsequent rise in genetic research and genetics-based tests and treatments, the term ‘personalized medicine’ is being used more frequently. But what does it mean? This explainer outlines what personalized medicine is, its advantages and some concerns that have been raised in relation to it….
Analysis of nucleoporin 107 overexpression
Introduction Lung cancer is one of the most common types of cancer worldwide and the leading cause of cancer death.1 The main category of lung cancer is non-small cell lung cancer, accounting for about 85%, and lung adenocarcinoma, as a kind of non-small cell lung cancer, is the most frequently…
In silico study about the influence of electroporation parameters on the cellular internalization, spatial uniformity, and cytotoxic effects of chemotherapeutic drugs using the Method of Fundamental Solutions
Batista Napotnik T, Miklavčič D (2018) In vitro electroporation detection methods – an overview. Bioelectrochemistry 120:166–182. doi.org/10.1016/j.bioelechem.2017.12.005 Article CAS PubMed Google Scholar Kotnik T, Rems L, Tarek M, Miklavčič D (2019) Membrane electroporation and electropermeabilization: mechanisms and models. Annu Rev Biophys 48(1):63–91. doi.org/10.1146/annurev-biophys-052118-115451 Article CAS PubMed Google Scholar Rems L,…
Irreversible Electroporation Ablators Market Size 2023 – 2030 Global Industrial Analysis, Key Geographical Regions, Market Share, Top Key Players, Product Types and Forecast Research Report
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Dr Priya Hays, Ph.D., CEO/Science Writer at Hays Documentation Specialists, LLC, responds to “Tyranny of the Gene.” Is personalized medicine a threat to public health? Not really, but yes, it’s an argument for price controls and perhaps more regulations; we hear Tyranny of the Gene: Personalized Medicine’s Threat to Public…
IMUNON’s VP of R&D to Present at the Vaccines Summit-2023
Imunon, Inc. Dr. Jean Boyer to highlight updated data showing the advantages of IMUNON’s PlaCCine modality and its applicability to multiple pathogens LAWRENCEVILLE, N.J., Nov. 14, 2023 (GLOBE NEWSWIRE) — IMUNON, Inc. (NASDAQ: IMNN), a clinical-stage biotechnology company focused on harnessing the power of the immune system against cancer and…
Clearside Biomedical reports Q3 2023 results, updates on clinical trials and partnerships By Investing.com
© Reuters. Clearside Biomedical (NASDAQ:), in its Q3 2023 financial results and corporate update call, announced several achievements including the completion of enrollment in its Phase 2b wet age-related macular degeneration (AMD (NASDAQ:)) clinical trial, ODYSSEY. The company also disclosed a partnership with BioCryst (NASDAQ:) Pharmaceuticals and provided updates on…
Robust airway microbiome signatures in acute respiratory failure and hospital-acquired pneumonia
He, Q. et al. The epidemiology and clinical outcomes of ventilator-associated events among 20,769 mechanically ventilated patients at intensive care units: an observational study. Crit. Care 25, 44 (2021). Article PubMed PubMed Central Google Scholar Bellani, G. et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory…
IO Biotech enrols 380 patients with advanced melanoma in phase 3 trial
The trial is evaluating an investigational cancer vaccine in combination with Keytruda IO Biotech has announced that it has completed the enrolment of 380 patients in a phase 3 clinical trial of its investigational immune-modulating therapeutic cancer vaccine in advanced melanoma. The open-label, randomised clinical study being…
FDA agrees to design of phase 3 trial for choroidal melanoma treatment
November 13, 2023 1 min read Add topic to email alerts Receive an email when new articles are posted on Please provide your email address to receive an email when new articles are posted on . “ data-action=”subscribe”> Subscribe We were unable to process…
IO Biotech enrolls 380 Patients in phase 3 advanced melanoma trial
IO102-IO103 is an investigational immune-modulating therapeutic cancer vaccine designed to target immunosuppressive mechanisms. Metastatic melanoma is a life-threatening cancer and although many new treatments have been introduced over the last decade that have significantly improved the outcomes for patients, there remains a high unmet need for more efficacious options with…
Research Discovering a Mutated Gene that Boosts Melanoma’s Immortality by Defeating Normal Replication Limits
Unlocking the Secrets of Cell Immortality Cancer cells possess a defining characteristic that sets them apart from normal cells: immortality. Unlike normal cells, which have a limited number of times they can replicate, cancer cells can overcome this limitation. Telomeres, repetitive sequences of DNA located at the ends of chromosomes,…
ncRNA | Free Full-Text | An Overview of the Immune Modulatory Properties of Long Non-Coding RNAs and Their Potential Use as Therapeutic Targets in Cancer
Non-Coding RNA 2023, 9(6), 70; doi.org/10.3390/ncrna9060070 (registering DOI) Non-Coding RNA 2023, 9(6), 70; doi.org/10.3390/ncrna9060070 (registering DOI) Received: 27 June 2023 / Revised: 25 October 2023 / Accepted: 8 November 2023 / Published: 11 November 2023 Round 1 Reviewer 1 Report Comments and Suggestions for Authors In the current manuscript, Moises et al….
Tumor microenvironment heterogeneity in bladder cancer identifies biologically distinct subtypes predicting prognosis and anti-PD-L1 responses
Bladder cancer is the most prevalent cancer of the urological system and it is histologically and genomically heterogeneous, which results in highly variable outcomes. Although improved strategies, such as the introduction of Bacillus Calmette-Guerin (BCG) and cisplatin-based chemotherapy, have significantly improved prognosis, that of high-risk, advanced, and metastatic BCa remains…
IO Biotech Completes Enrollment of 380 Patients in Pivotal Phase 3 Trial in Advanced Melanoma
IO Biotech Trial expected to reach the primary endpoint of progression free survival in the second half of 2025 Per-protocol interim analysis expected in mid-2024 NEW YORK, Nov. 10, 2023 (GLOBE NEWSWIRE) — IO Biotech (Nasdaq: IOBT), a clinical-stage biopharmaceutical company developing novel, immune-modulating therapeutic cancer vaccines, announced today that…
Most large structural variants in cancer genomes can be detected without long reads
JaBbA v1 outperforms previous CN algorithms We enhanced our previous JaBbA (v0.1; ref. 4) model with several methodological innovations to increase robustness to read depth waviness, improve algorithm convergence and enforce junction balance for allele-specific as well as total CN (Extended Data Fig. 1a–d and Methods). We also rigorously defined…
MaaT Pharma Provides Third Quarter 2023 Business Update and Reports Financial Results
MaaT Pharma Provides Third Quarter 2023 Business Update and Reports Financial Results Independent Data Safety Monitoring Board (DSMB) reviewing the Phase 3 ARES trial evaluating MaaT013 in aGvHD concluded on a positive benefit/risk ratio based on a good safety profile and positive preliminary efficacy results with an Overall Response Rate…
KEGG T01028: 701915
Entry 701915 CDS T01028 Symbol KRT25 Name (RefSeq) keratin, type I cytoskeletal 25 KO K07604 type I keratin, acidic Organism mcc Macaca mulatta (rhesus monkey) Pathway mcc04915 Estrogen signaling pathway mcc05150 Staphylococcus aureus infection Brite KEGG Orthology (KO) [BR:mcc00001] 09150 Organismal Systems 09152 Endocrine system 04915 Estrogen signaling pathway 701915 (KRT25) 09160 Human Diseases 09171 Infectious disease: bacterial 05150 Staphylococcus…
Matinas BioPharma Reports Third Quarter 2023 Financial Results and Provides a Business Update
Matinas BioPharma Holdings, Inc. FDA feedback on MAT2203 Phase 3 program supports a patient population in invasive aspergillosis with limited treatment options, acknowledges potential for LPAD pathway; composite superiority endpoint under evaluation to strengthen commercial opportunity without increasing study size Patient with Candida krusei infection achieved complete clinical resolution with…
FAT10 is phosphorylated by IKK{beta} to inhibit the antiviral type-I interferon response
Introduction The innate immune system represents the host´s first-line defense against viral infections (Koyama et al, 2008). In this context, IFN-I are produced by all nucleated cells and represent the principal cytokines that counteract viral replication (Ivashkiv & Donlin, 2014). In fact, several receptors of the infected cell can recognize…
Cloves Syndrome Market Share And Industry Trends 2023-2030
North America Accounted for Approximately 39.2% of the Market Share in 2022, Owing to the Increasing Funding, and Availability of Targeted Treatments. Cloves Syndrome Market Outlook Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevis, Spinal/Skeletal Anomalies/Scoliosis (CLOVES) syndrome is a very rare congenital (present at birth) disorder characterized by a combination…
Insights gained from single-cell analysis of chimeric antigen receptor T-cell immunotherapy in cancer | Military Medical Research
Zhu J, Ke Y, Liu Q, Yang J, Liu F, Xu R, et al. Engineered Lactococcus lactis secreting Flt3L and OX40 ligand for in situ vaccination-based cancer immunotherapy. Nat Commun. 2022;13(1):7466. Article CAS PubMed PubMed Central Google Scholar Evans ER, Bugga P, Asthana V, Drezek R. Metallic nanoparticles for cancer…
Boston University researcher receives grant t
(Boston)—Deborah Lang, PhD, associate professor of dermatology at Boston University Chobanian & Avedisian School of Medicine, has been awarded a two-year, $300,000 Discovery Boost Grant from the American Cancer Society (ACS) for her research project “Exploring roles for PAX3 in regulating gene expression on a post transcriptional level.” Lang…
BioAtla Reports Third Quarter 2023 Financial Results and Highlights Recent Progress
BioAtla, Inc. Observed additional clinical responses and FDA feedback supports path forward for CAB-AXL-ADC (BA3011) non-small cell lung cancer (NSCLC) registrational study; detailed interim Phase 2 data to be presented at upcoming IASLC conference in early December and discussed at KOL event on December 4, 2023 Observed new PRs with…
Genomic Cancer Testing is projected to Hit $45.92 Billion, Globally, by 2030 at 16.1% CAGR: Coherent Market Insights
Genomic Cancer Testing is projected to Hit $45.92 Billion, Globally, by 2030 at 16.1% CAGR: Coherent Market Insights Burlingame, Nov. 07, 2023 (GLOBE NEWSWIRE) — According to Coherent Market Insights, global genomic cancer testing market is estimated to be valued at US$ 16.15 billion in 2022 and is expected to…
Unveiling the transcriptomic and epigenetic secrets across 11 tumors
In a recent study published in Nature, researchers created a pan-tumor transcriptomic and epigenetic atlas using single-nucleus chromatin accessibility information and matched ribonucleic acid (RNA)-sequencing data. Study: Epigenetic regulation during cancer transitions across 11 tumour types. Image Credit: ART-ur/Shutterstock.com The researchers studied the spatiotemporal dynamics of chromatin decondensation and transcriptional…
Aura Biosciences Receives FDA Agreement Under Special Protocol Assessment (SPA) for CoMpass Phase 3 Clinical Trial of Belzupacap Sarotalocan (Bel-sar) in Early-stage Choroidal Melanoma
Positive Clinical Efficacy Updates of Bel-sar for Early-Stage Choroidal Melanoma from the Ongoing Phase 2 Clinical Trial with Suprachoroidal Administration Presented at AAO 2023 Preliminary Data from Phase 1 Trial in Bladder Cancer – First Patient Utilizing a Single Dose of Bel-sar with Light Activation Demonstrated a Clinical Complete Response…
Aura Biosciences Gets FDA Agreement Regarding Phase 3 Clinical Trial of Bel-Sar
By Stephen Nakrosis Aura Biosciences on Monday said it received agreement from the U.S. Food and Drug Administration for the design and plan of a Phase 3 trial of belzupacap sarotalocan as a treatment for patients with early-stage choroidal melanoma. The company said it received the agreement from the FDA…
Aura Biosciences Gets FDA Agreement Regarding Phase 3 Clinical Trial of Bel-Sar -November 06, 2023 at 03:36 pm EST
By Stephen Nakrosis Aura Biosciences on Monday said it received agreement from the U.S. Food and Drug Administration for the design and plan of a Phase 3 trial of belzupacap sarotalocan as a treatment for patients with early-stage choroidal melanoma. The company said it received the agreement from the FDA…
Characterization of the genomic alterations in poorly differentiated thyroid cancer
Cancer Genome Atlas Research, N. Integrated genomic characterization of papillary thyroid carcinoma. Cell 159, 676–690. doi.org/10.1016/j.cell.2014.09.050 (2014). Sherman, S. I. Thyroid carcinoma. Lancet 361, 501–511. doi.org/10.1016/s0140-6736(03)12488-9 (2003). Article PubMed Google Scholar Tong, J. et al. Poorly differentiated thyroid carcinoma: a clinician’s perspective. Eur. Thyroid J. 11, doi.org/10.1530/ETJ-22-0021 (2022). Asioli, S….
Detection of the Uveal Melanoma-Associated Mutation GNAQ Q209P from Liquid Biopsy Using CRISPR/Cas12a Technology
Uveal melanoma (UM) is a rare ocular tumor characterized by high metastasis risk and poor prognosis. The in-depth characterization of UM’s molecular profile is critical for better disease classification and prognosis. Furthermore, the development of detection tools to monitor UM evolution upon treatment is of great interest for designing optimal…
CRISPR screening in hematology research: from bulk to single-cell level | Journal of Hematology & Oncology
Transcriptomics CROP-seq [46] Jurkat Poly-A CRISPRko Cas9 119 – 5798 (+ 1320 cells with NT gRNA) Lentiviral DROP-seq RNA Perturb-seq [43, 44] K562 Barcode CRISPRi dCas9-KRAB UPR epistasis screen: 9 triplet combinations UPR Perturb-seq experiment: 91 Up to 3 gRNAs in a single vector UPR epistasis screen: 15006 UPR Perturb-seq experiment:…
Regeneron Reports Third Quarter 2023 Financial and Operating Results
Third quarter 2023 revenues increased 15% to $3.36 billion versus third quarter 2022 Third quarter 2023 Dupixent® global net sales(recorded by Sanofi) increased 33% to $3.10 billion versus third quarter 2022 Third quarter 2023 U.S. net sales for EYLEA® and EYLEA HD were $1.49 billion, including $43…
Insights into expression patterns and immunotherapy response prediction
[1] D. Schadendorf, D. E. Fisher, C. Garbe, J. E. Gershenwald, J. Grob, A. Halpern, et al., Melanoma, Nat. Rev. Dis. Primers, 1 (2015), 15003. doi.org/10.1038/nrdp.2015.3 doi: 10.1038/nrdp.2015.3 [2] A. M. M. Eggermont, A. Spatz, C….
Fasting-Mimicking Diet Drives Antitumor Immunity against Colorectal Cancer by Reducing IgA-Producing Cells | Cancer Research
Fasting-mimicking diet (FMD) is emerging as an effective dietary intervention with the potential to prolong life span in healthy people and boost antitumor immunity in patients with cancer. FMD refers to a medically designed fasting-like state that allows periodic consumption of a very-low-calorie and low-protein diet (1, 2). Compared with…
Synergistic effects of Azithromycin and DMXAA
Kanoktip Petcharat,1 Narongsuk Munkong,2 Rungthip Thongboontho,1 Widsanusan Chartarrayawadee,3 Arthid Thim-Uam1 1Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand; 2Department of Pathology, School of Medicine, University of Phayao, Phayao, 56000, Thailand; 3Division of Chemistry, School of Science, University of Phayao, Phayao, 56000, Thailand Correspondence: Arthid Thim-Uam,…
What does the future hold?
In this interview, Adanma Ayanambakkam, MD, discusses the current state of treatment of advanced bladder cancer, including the need for predictive and prognostic markers for immune therapy as well as the potential showed by circulating tumor DNA (ctDNA). Ayanambakkam is an assistant professor of medicine in the section of hematology/oncology…