Tag: MMR

Xiao S, Li Q, Jiang J, Huo C, Chen H and Guo M (2023) Rapid Identification of chinese Hamster ovary cell apoptosis and its potential role in process Robustness Assessment. Bioengineering (Basel) 10. doi.org/10.3390/bioengineering10030357 Bryan L, Clynes M and Meleady P (2021) The emerging role of cellular post-translational modifications in…

Introduction Traditional Chinese herbal medicine plays an indispensable role in the treatment of multiple diseases in China and other developing countries (Newman et al., 2008). Apart from the traditional usage, many medicinal plants, such as Artemisia annua L. (artemisinin, Tu, 2016), Huperzia javanica (Sw.) C. Y. Yang (Huperzine A, Zangara, 2003;…

Gene Editing Market Gene Editing Market Report Scope and Research Methodology The gene editing market report aims to provide a comprehensive analysis of the global gene editing industry, including its current state, growth prospects, key trends, and competitive landscape. The scope of the report encompasses various gene editing technologies, such…

Pune, May 25, 2023 (GLOBE NEWSWIRE) — Maximize Market research, a global market research firm has published a competitive intelligence market research report on the “DNA Polymerase Market”. The DNA Polymerase Market size was valued at USD 3.7 Bn in 2022. The total DNA Polymerase Market revenue is expected to…

Entry 120500365         CDS       T07277                                  Symbol SRP54 Name (RefSeq) signal recognition particle 54 kDa protein   KO K03106   signal recognition particle subunit SRP54 [EC:3.6.5.4] Organism pmoa  Passer montanus (Eurasian tree sparrow) Pathway pmoa03060   Protein export Brite KEGG Orthology (KO) [BR:pmoa00001] 09120 Genetic Information Processing  09123 Folding, sorting and degradation   03060 Protein export    120500365 (SRP54) 09180 Brite Hierarchies  09183 Protein families: signaling…

My colon cancer patients are getting younger. The diagnoses are happening just as some of these individuals are embarking on their plans for life, while others are in the crucial midst of parenthood. Given this, the tragedy of their cancers feels exponentially greater. This youthful trend in my clinic is…

CRISPR And Cas Genes Market CRISPR And Cas Genes Market Report Scope and Research Methodology The report provides a detailed analysis of the CRISPR And Cas Genes Market dynamics, focusing on regional insights and application industries. It offers valuable information about the market’s market values, drivers, restraints, and research methodology….

DNA Polymerase Market DNA Polymerase Market Report Scope and Research Methodology The DNA polymerase market report aims to provide a comprehensive analysis of the global market. The report covers various factors that influence the growth of the market, including drivers, restraints, opportunities, and challenges. The report also provides an in-depth…

Genotyping Market Genotyping Market Report Scope and Research Methodology The report provides a holistic view of the market by integrating qualitative and quantitative data. The data was collected through primary and secondary research methods, including surveys, interviews with key industry players, and data analysis of reputable sources. For detail insights…

Long Read Sequencing Market According to a new report by MMR, the Long Read Sequencing Market size was valued at USD 1488 Mn. in 2022 and is expected to reach USD 6520.7 Mn. by 2029 at a CAGR of 23.5 percent during the forecast period. Long Read Sequencing Market Report…

Ethics declaration Animal study was performed following the Guide for the Care and Use of Laboratory Animals. Animal experiment was approved by the Institutional Animal Care and Use Committee of Colorado State University (protocol number 1090) in advance and conducted in compliance with the Association for the Assessment and Accreditation…

Carrier Screening Market to hit USD 5.19 Bn by 2029 at a CAGR of 14.6 percent – says Maximize Market Research Dublin, May 02, 2023 (GLOBE NEWSWIRE) — A global Information Technology & Telecommunication research and business-consulting firm, Maximize Market Research, has published a market intelligence report on the “…

Adding immunotherapy to chemotherapy continues to be the standard treatment method for patients with endometrial cancer, regardless of disease stage, according to John Nakayama, MD. Recent data presented at the Society of Gynecologic Oncology (SGO) Annual Meeting may bring additional combinations to the armamentarium. The phase 3 NRG-GY018 study (NCT03914612)…

To most people in the world, we millennials in particular, before the year 2020 the idea of pandemics seemed confined to history textbooks and to Hollywood movies. None of us could have had an inkling as to the turn our lives were about to take. Our hubris was soon checked,…

Optimizing prime editing systems for HSPCs We previously reported the use of prime editing to correct HBBS by plasmid transfection in HEK293T cells containing the SCD mutation, reaching up to 58% efficiency (Fig. 1a)24. In contrast to HEK293T cells, HSPCs are difficult to transfect with plasmid DNA but are amenable…

Rojansky R, Cha M-Y, Chan DC (2016) Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. eLife 5:e17896. doi.org/10.7554/eLife.17896 CrossRef  CAS  PubMed  PubMed Central  Google Scholar  Wei W, Pagnamenta AT, Gleadall N et al (2020) Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA…

Differential expression of DDR1 between tumor and normal tissue samples To better understand DDR1 expression levels in various cancer types, we first performed a pan-cancer analysis of 33 cancers in the TCGA database. Excluding cancers without corresponding normal samples, significant differences in DDR1 expression were found between tumor and normal…

Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell doi.org/10.1016/j.cell.2006.07.024 (2006). Article  PubMed  Google Scholar  Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147. doi.org/10.1126/science.282.5391.1145 (1998). Article  ADS  CAS  PubMed  Google…

National Vaccination Day 2023 National Vaccine Day is celebrated on 16 March every year. The COVID-19 and subsequent development of vaccines have made information on vaccines especially relevant for candidates aspiring for various competitive examinations. The idea behind the celebration of National Vaccine Day is to spread awareness and highlight…

Disrupting the natural DNA replication fidelity mechanism to increase mutation rates The high fidelity of genome replication processes in biological cells is ensured by multiple levels of proofreading and repair mechanisms25, including base selection, 3’->5’ exonuclease activity, methyl-directed mismatch repair (MMR), DNA damage repair, translesion DNA synthesis (TLS), etc. (Fig. 1)….

NEW YORK – A team led by researchers at the Wellcome Sanger Institute has come up with a machine learning method for predicting genome editing efficiency when using a CRISPR-Cas9-based approach known as prime editing. The approach relies on prime editors capable of making precise changes to single bases or…

As part of CancerNetwork’s Face-Off video series, Talha Badar, MBBS, MD, assistant professor of oncology, Mayo Clinic, discussed results from the phase 3 ASCEMBL study (NCT03106779) of asciminib (Scemblix) versus bosutinib (Bosulif) in patients with chronic myeloid leukemia in chronic phase (CML-CP) after ≥2 prior tyrosine kinase inhibitors (TKIs). Badar:…

Pembrolizumab plus chemotherapy appears to produce a significant improvement in progression-free survival among patients with advanced or recurrent endometrial cancer. Treatment with pembrolizumab (Keytruda) in combination with chemotherapy yielded a statistically significant and clinically meaningful improvement in progression-free survival (PFS) compared with chemotherapy alone among patients with stage III/IV or…

Introduction Polycystic ovary syndrome (PCOS) is the most common endocrine disease occurring during reproductive years. It was a kind of endocrine and metabolic disorders that results in obesity, irregularity of menstruation, OS, hyperinsulinemia, hyperandrogenism, infertility, and sterility.1,2 First identified in 1935, PCOS was also recognized as Stein–Leventhal syndrome.3 Diagnosis of…

Spandidos Publications style Zhang X, Yang S, Han S, Sun Y, Han M, Zheng X, Li F, Wei Y, Wang Y, Bi J, Bi J, et al: Differential methylation of circRNA m6A in an APP/PS1 Alzheimer’s disease mouse model. Mol Med Rep 27: 55, 2023 APA Zhang, X., Yang, S.,…

Lund University, Scania, Sweden invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at Lund University, Scania, Sweden. Eligible candidate may Apply as soon as possible.   (01) Postdoctoral Fellowship Position Postdoc Fellowship Position summary/title:  Postdoctoral researcher in…

Introduction Stroke is one of the leading causes of death and disability worldwide, which causes substantial economic and social burdens.1 Ischemic stroke is caused by insufficient blood and oxygen supply to the brain,2 accounting for about 85% of the casualties of stroke patients.3 The concept of treatment for ischemic injury…

DNM filtering in 100,000 Genomes Project We analysed DNMs called in 13,949 parent–offspring trios from 12,609 families from the rare disease programme of the 100,000 Genomes Project. The rare disease cohort includes individuals with a wide array of diseases, including neurodevelopmental disorders, cardiovascular disorders, renal and urinary tract disorders, ophthalmological…

Expression of CD68 in pan-cancer First, to fully clarify the expression of CD68 in pan-cancer, we matched the GTEx normal samples with TCGA tumor samples (Fig. 1A). We found that the levels of CD68 were significantly elevated (P < 0.01) in colon adenocarcinoma (COAD), glioblastoma multiforme (GBM), kidney renal clear cell carcinoma (KIRC),…

Fassio F, Facioni MS, Guagnini F. Lactose maldigestion, malabsorption, and intolerance: a comprehensive review with a focus on current management and future perspectives. Nutrients. 2018. doi.org/10.3390/nu10111599. Article  PubMed  PubMed Central  Google Scholar  Gibson PR, Newnham E, Barrett JS, et al. Review article: fructose malabsorption and the bigger picture. Aliment Pharmacol…

Defeng Pan,1,&ast; Yufei Zhou,2,&ast; Shengjue Xiao,1,&ast; Yue Hu,3,&ast; Chunyan Huan,1 Qi Wu,1 Xiaotong Wang,1 Qinyuan Pan,1 Jie Liu,1 Hong Zhu1 1Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People’s Republic of China; 2Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of…

Introduction Diabetes is a very complex disease characterized by the presence of chronic hyperglycemia. Clinically, insulin-dependent type 1 and non-insulin-dependent type 2 are the main types of diabetes. Among them, type 2 diabetes mellitus (T2DM, [MIM125853]) is a common endocrine disorder affecting approximately 10% of adult population.1 In most cases,…

Johns Hopkins University Advanced Academic Programs Biotechnology Program Adjunct Faculty: Bioinformatics (Introduction to Bioinformatics, Practical Computer Concepts for Bioinformatics, Metagenomics) Institution Description: The Advanced Academic Programs (AAP) is a division of the Krieger School of Arts and Sciences at the Johns Hopkins University (JHU). As the nation’s oldest and one…

Introduction Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent (ranking above HIV/AIDS).1 In 2020, World Health Organization (WHO) reported that 7.1 million people with tuberculosis were newly diagnosed and notified in 2019,…