Tag: MMR

Expert Guidelines Detail Optimal Sequencing of Emerging Therapies for Metastatic Castration-Resistant Prostate Cancer, Journal Club

Read the Full Video Transcript Rashid Sayyid: Hello everyone and thank you for joining us in this UroToday recording. I’m Rashid Sayyid, the Urologic Oncology Fellow at the University of Toronto, and along with Zach Klaassen, Associate Professor Program Director at Wellstar MCG Health, we’ll be discussing the recently amended…

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transforming global healthcare with innovative vaccines

Vaxxinity, Inc. is a purpose-driven U.S.-based biotechnology company looking to develop vaccines for several hard-to-treat diseases.  The company, led by this week’s podcast guest, Mei Mei Hu, said it is committed to democratizing global healthcare.  The company is pioneering a new class of medicines aimed at disrupting the existing treatments…

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The Protective Mechanism of TFAM on Mitochondrial DNA and its Role in Neurodegenerative Diseases

Annesley SJ, Fisher PR (2019) Mitochondria in health and disease. Cells 8(7). doi.org/10.3390/cells8070680 Cannino G, Ferruggia E, Luparello C, Rinaldi AM (2009) Cadmium and mitochondria. Mitochondrion 9(6):377–384. doi.org/10.1016/j.mito.2009.08.009 Article  CAS  PubMed  Google Scholar  Bonora M, Missiroli S, Perrone M, Fiorica F, Pinton P, Giorgi C (2021) Mitochondrial control of genomic…

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Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition

Patients, tumour Implantation, PDX expansion and characterization The study was conducted according to the Declaration of Helsinki. Tumours were collected from EC patients following Human Research Ethics Committee (HREC) approval (HREC/15/MHS/127) and QUT HREC (#1500000169, 1500000323). All participants provided written informed consent that their excess tissue could be used for…

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Bam files generated with STAR cause a segmentation fault core dump error when used with another tool

I am mapping RNA-Seq data using STAR, using multi-sample two-pass mapping. I first mapped all samples with one-pass then concatenated their SJOut files and filtered junctions. I launched the second mapping by using this SJOut file. I used this command to generate genome : ` /home/STAR-2.7.10b/bin/Linux_x86_64/STAR \ –runThreadN 10 \…

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Researchers introduce CRISPR-mediated genome and cancer shredding as a conceptual paradigm to treat recurrent gliomas

In a recent study published in Cell Reports, researchers demonstrated clustered regularly interspersed short palindromic repeats (CRISPR)-mediated elimination of glioblastoma (GBM) cells. Study: Targeting the non-coding genome and temozolomide signature enables CRISPR-mediated glioma oncolysis. Image Credit: ART-ur/Shutterstock.com Background Primary GBM is an aggressive tumor that is challenging to treat. The…

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Chemo Plus Tecentriq Shows Improvements in Endometrial Carcinoma

A phase 3 trial demonstrated progression-free survival improvements with Tecentriq-chemotherapy combination in patients with endometrial carcinoma. The treatment combination of Tecentriq (atezolizumab) and platinum-based chemotherapy demonstrated benefits for patients with frontline advanced or recurrent endometrial carcinoma, specifically patients with deficient mismatch repair (dMMR) status, according to data from a phase…

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Phase 3 DUO-E Study Findings Prove ‘Exciting’ in Advanced Endometrial Cancer

Findings from the phase 3 DUO-E/GOG-3041/ENGOT-EN10 trial (NCT04269200)—assessing combination chemotherapy/durvalumab (Imfinzi), single-agent durvalumab, and durvalumab/olaparib (Lynparza) in patients with newly diagnosed advanced or recurrent endometrial cancer—were “exciting,” according to Shannon N. Westin, MD, MPH, FACOG. In a conversation with CancerNetwork® during the 2023 Annual Global Meeting of the International Gynecologic…

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Molecular-based classification of endometrial carcinoma in Northern Thailand: impact on prognosis and potential for implementation in resource-limited settings | BMC Women’s Health

Study population The study cohort included women diagnosed with endometrial carcinoma at Chiang Mai University Hospital during January 2015 to December 2017. Inclusion criteria were patients with informed consent, available hysterectomy specimens for evaluation, and available clinical information and pathological results. We excluded individual without histologic materials and formalin-fixed paraffin-embedded…

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Medicenna Therapeutics Reports Second Quarter Fiscal 2024 Financial Results and Operational Highlights

Cash runway extended through multiple data readouts and into Q1 of calendar 2025 MDNA11 is generally well tolerated and continues to demonstrate encouraging single-agent activity from Phase 1 portion of the ABILITY-1 Study including 100% and 70% reduction of target lesions in pancreatic and melanoma cancer patients, respectively Four-year follow-up…

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KEGG T01028: 717682

Entry 717682            CDS       T01028                                  Symbol SEPTIN2 Name (RefSeq) septin-2 isoform X1   KO K16942   septin 2 Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc05100   Bacterial invasion of epithelial cells Brite KEGG Orthology (KO) [BR:mcc00001] 09160 Human Diseases  09171 Infectious disease: bacterial   05100 Bacterial invasion of epithelial cells    717682 (SEPTIN2) 09180 Brite Hierarchies  09182 Protein families: genetic information processing   04131 Membrane trafficking…

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Laser Diode Market is expected to grow at a CAGR of 12.3 % during the forecast period 2022-2029 according to a new research report

Global Laser Diode Market report helps with the PESTEL, PORTER, COVID-19 Impact analysis, Recommendations for Investors & Leaders, and market estimation of the forecast period Laser Diode Market Report Scope and Research Methodology: Global Laser Diode Market utilize semiconductors to generate laser radiations with uniform wavelengths. The operation of a laser diode involves three…

Continue Reading Laser Diode Market is expected to grow at a CAGR of 12.3 % during the forecast period 2022-2029 according to a new research report

Mutational spectra are associated with bacterial niche

Bacteria exhibit diverse mutational spectra Using a specifically-developed open-source bioinformatic tool, MutTui (github.com/chrisruis/MutTui), we analysed whole genome sequence alignments and phylogenetic trees to reconstruct single base substitution (SBS) mutational spectra of 84 phylogenetic clades from 31 diverse bacterial species representing a broad range of phylogenetic diversity and replication sites (Figs. S1…

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Karyopharm Therapeutics Reports Q3 2023 Financial Results, Highlights Strong Position for Growth By Investing.com

© Reuters. Karyopharm Therapeutics (NASDAQ: NASDAQ:) has reported its financial results for the third quarter of 2023, noting a strong position for growth backed by its pipeline of innovative oral selective inhibitors and nuclear export. The company expects total revenues of $145 million to $160 million in 2023, and anticipates…

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NCT/DKFZ MASTER handbook of interpreting whole-genome, transcriptome, and methylome data for precision oncology

Patient characteristics and tissue context The clinical interpretation of molecular alterations starts with evaluating relevant patient characteristics and the tissue context in which a genetic profile occurs. The former relates, in particular, to previous therapies, in addition to disease stage and clinical performance status. For example, prior targeted therapies warrant…

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Identification of hub genes associated with gastric cancer

Introduction GC is a common malignant tumor of digestive system. According to the International Agency for Research on Cancer (IARC) of the World Health Organization, there were 19.29 million new cancer cases and 9.96 million deaths worldwide in 2020, of which the number of new cases of GC was 1089,103…

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Create ggplot function in R

library(ggplot2) library(sf) # Function to create the desired plot create_plot <- function(data) { tryCatch({ # Check if the required columns exist in the data if (!(“Indicator” %in% colnames(data)) || !(“stat” %in% colnames(data)) || !(“County.f” %in% colnames(data))) { stop(“Required columns not found in the data”) } # Create the bar plot…

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Maintenance Durvalumab Plus Olaparib Improves PFS in Advanced or Recurrent Endometrial Cancer

Shannon N. Westin, MD, MPH, FACOG The addition of durvalumab (Imfinzi) to first-line chemotherapy, followed by maintenance treatment with durvalumab plus olaparib (Lynparza) significantly improved progression-free survival (PFS) in patients with newly diagnosed advanced or recurrent endometrial cancer, according to data from the phase 3 DUO-E/GOG-3041/ENGOT-EN10 trial (NCT04269200) presented at…

Continue Reading Maintenance Durvalumab Plus Olaparib Improves PFS in Advanced or Recurrent Endometrial Cancer

Durvalumab/Olaparib Maintenance Induces PFS Benefit in Advanced, Recurrent Endometrial Cancer

The addition of durvalumab (Imfinzi) to first-line chemotherapy, followed by maintenance therapy with the anti-PD-L1 antibody plus olaparib (Lynparza) improved progression-free survival (PFS) in patients with newly diagnosed advanced or recurrent endometrial cancer, according to data from the phase 3 DUO-E/GOG-3041/ENGOT-EN10 trial (NCT04269200) presented at ESMO Congress 2023.1-3 In particular,…

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Integration of phenotypic, qPCR and genome sequencing methodologies for the detection of antimicrobial resistance and virulence in clinical isolates of a tertiary hospital, India

Azimi A, Peymani A, Pour PK (2018) Phenotypic and molecular detection of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates from patients with burns in Tehran. Iran Rev Soc Bras Med Tro 51:610–615. doi.org/10.1590/0037-8682-0174-2017 Article  Google Scholar  Aziz RK, Bartels D, Best AA et al (2008) The RAST server: rapid annotations using subsystems technology….

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Bioinformatics Analyst in Baltimore, MD for Johns Hopkins University

Details Posted: 14-Oct-23 Location: Baltimore, Maryland Salary: Open Categories: Research – Laboratory/Non-Laboratory Staff/Administrative Internal Number: 111298-en_US The Department of Neurology is seeking a Bioinformatics Analyst. The Analyst will be responsible for 2 major bioinformatics tasks requiring very specific bioinformatics and coding skills. Specific Duties & Responsibilities The collection, processing, and…

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The mutational signature of hypertrophic cardiomyopathy

Introduction Hypertrophic cardiomyopathy (HCM), characterized by asymmetric hypertrophy of the ventricular wall, is a condition where the heart becomes thickened without a distinct inducement.1,2 Epidemiological investigation shows that the estimated prevalence rate of HCM in the general population is 1:500.3,4 The clinical manifestations vary greatly, with no symptoms and mild…

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FGFR2 genetic variants in women with breast cancer

Spandidos Publications style Dix‑Peek T, Dickens C, Augustine TN, Phakathi BP, Van Den Berg EJ, Joffe M, Ayeni OA, Cubasch H, Nietz S, Mathew CG, Mathew CG, et al: FGFR2 genetic variants in women with breast cancer. Mol Med Rep 28: 226, 2023 APA Dix‑Peek, T., Dickens, C., Augustine, T.N.,…

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Functional analysis of differentially expressed circular RNAs in sheep subcutaneous fat | BMC Genomics

Chikwanha, O. C., P. Vahmani, V. Muchenje, M. E. R. Dugan and C. Mapiye (2018). Nutritional enhancement of sheep meat fatty acid profile for human health and wellbeing. Food research international (Ottawa, Ont.) 104: 25–38. doi.org/10.1016/j.foodres.2017.05.005. Khan R, Raza SHA, Schreurs N, Xiaoyu W, Hongbao W, Ullah I, et al….

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KEGG T00123: EF1761

Entry EF1761            CDS       T00123                                  Symbol ftsE Name (RefSeq) cell division ATP-binding protein FtsE   KO K09812   cell division transport system ATP-binding protein Organism efa  Enterococcus faecalis V583 Pathway efa02010   ABC transporters Brite KEGG Orthology (KO) [BR:efa00001] 09130 Environmental Information Processing  09131 Membrane transport   02010 ABC transporters    EF1761 (ftsE) 09180 Brite Hierarchies  09182 Protein families: genetic information processing   03036 Chromosome and associated…

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Salani Reviews Options for a Patient With Metastatic Endometrial Cancer

Ritu Salani, MD, MBA Gynecologic Oncologist UCLA Health Los Angeles, CA CASE SUMMARY August 2021 A 64-year-old postmenopausal woman presented with abnormal uterine bleeding lasting 4 months. She noted that she underwent menopause at 55 years of age. She is a widow, has no children, and lives alone. Medical history:…

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Uncovering the mechanisms underlying lack of

image: Immune cells surrounding a tumour with clonal neoantigens view more  Credit: Karen Arnott/EMBL-EBI A new study has shed light on why immunotherapy does not always work in certain types of cancer. Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of…

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Immunotherapy Failure Linked to Intratumoral Heterogeneity

The results of a study led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and Massachusetts Institute of Technology (MIT), have shed light on why immune checkpoint blockade (ICB) immunotherapy does not always work in some cancers with a high tumor mutational burden (TMB). The…

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Revealing Why Some Patients Don’t Respond to Immunotherapy

A new study has shed light on why immunotherapy does not always work in certain types of cancer. Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of Technology (MIT), the work focuses on understanding why some tumours fail to respond…

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Uncovering the mechanisms underlying lack of response to immunotherapy

A new study has shed light on why immunotherapy does not always work in certain types of cancer. Led by researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), Cold Spring Harbor Laboratory (CSHL), and the Massachusetts Institute of Technology (MIT), the work focuses on understanding why some tumours fail to respond…

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Integrated bioinformatics analysis of noncoding RNAs with tumor immune microenvironment in gastric cancer

Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209–249. doi.org/10.3322/caac.21660 (2021). Article  PubMed  Google Scholar  Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2022. CA A…

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Perspectives of circular RNAs in diabetic complications from biological markers to potential therapeutic targets (Review)

Authors: Lingling Yuan Jinsheng Duan Hong Zhou View Affiliations Affiliations: Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China, Department of Endocrinology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei…

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Pembrolizumab Added to Chemotherapy Improves PFS in Endometrial Cancer

Ovarian cancer cell © LASZLO – stock.adobe.com Adding pembrolizumab to standard chemotherapy led to significantly longer progression-free survival (PFS) rates vs chemotherapy alone among patients with advanced or recurrent endometrial cancer, according to findings from the phase 3 NRG-GY018 trial (NCT03914612).1 Currently, paclitaxel plus carboplatin is the standard first-line chemotherapy…

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KRTA6A and FA2H Are Hub Genes Associated With Cgas-STING-related Immunogenic Cell Death in Lung Adenocarcinoma

Abstract Background/Aim: The immunogenic cell death (ICD) pathway plays a crucial prognostic role in lung adenocarcinoma (LUAD) therapy. The cyclic GMP–AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is an upstream mechanism that drives ICD activation, but the interaction of hub genes remains unclear. The present study aimed to investigate…

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Fact Check: mRNA NOT Added To All Childhood Vaccines Without Regulatory Reapproval — Any Changes Require Vaccines To Be Treated As New Product, Re-Evaluated

Must Be OK’d Is mRNA being integrated into “every childhood vaccine” without regulatory reapproval? No, that’s not true: The U.S. Food and Drug Administration (FDA) calls the claim “completely false.” There are rigorous regulatory processes in place to evaluate and approve any changes to vaccines, including the incorporation of new…

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Clinical Oncology Next-Generation Sequencing Market to reach

Clinical Oncology Next-Generation Sequencing Market Clinical Oncology Next-Generation Sequencing Market Report Scope The Clinical Oncology Next-Generation Sequencing (NGS) market, valued at $7.86 billion in 2022 and expected to reach nearly $2.93 billion by 2029 with a remarkable 20.7% CAGR, presents a comprehensive landscape encompassing various critical components. It revolves around…

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Altitude Marketing Announces Branding & Marketing Partnership with LS CancerDiag

Altitude Marketing, a full-service life sciences marketing and branding agency serving B2B companies for more than 19 years, recently announced a partnership with LS CancerDiag, the distinguished experts behind the groundbreaking DiagMMR® assay. EMMAUS, Pa. , Aug. 10, 2023 /PRNewswire/ — LS CancerDiag’s ultimate mission is to reduce cancer mortality…

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The LK-99 BS Further Undermines the Credibility of Science

Social media is afire with reports that South Korean researchers have synthesized a room-temperature and room-pressure superconductor they call K-99. This is the biggest scientific news this year—yes, ChatGPT is now so last year. A representative Wow! from experts has been: “If LK-99 is the real deal, it could be…

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CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten …

Original study Arch. Anim. Breed., 65, 55–67, 2022 Open Access doi.org/10.5194/aab-65-55-2022 © Author(s) 2022. This work is distributed under Archives Animal Breeding the Creative Commons Attribution 4.0 License. CircRNA-0100 positively regulates the differentiation of cashmere goat SHF-SCs into hair follicle lineage via sequestering miR-153-3p to heighten the KLF5 expression Junyin…

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Identification of immuno-inflammation-related biomarkers | JIR

Introduction Acute myocardial infarction (AMI) is the sudden irreversible necrosis of heart muscle, which commonly results from atherosclerotic plaque disruption and subsequent interruption of blood flow.1 It is one of the heart diseases with the highest prevalence and incidence and brings enormous health and financial burdens.2 Despite the rapid development…

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KEGG T01001: 23560

Entry 23560             CDS       T01001                                  Symbol GTPBP4, CRFG, NGB, NOG1 Name (RefSeq) GTP binding protein 4   KO K06943   nucleolar GTP-binding protein Organism hsa  Homo sapiens (human) Pathway hsa03008   Ribosome biogenesis in eukaryotes Brite KEGG Orthology (KO) [BR:hsa00001] 09120 Genetic Information Processing  09122 Translation   03008 Ribosome biogenesis in eukaryotes    23560 (GTPBP4) 09180 Brite Hierarchies  09182 Protein families: genetic information processing   03009 Ribosome…

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Sr. Research Specialist/Bioinformatics Specialist in Baltimore, MD for Johns Hopkins University

Details Posted: 26-Jul-23 Location: Baltimore, Maryland Salary: Open Categories: Research – Laboratory/Non-Laboratory Staff/Administrative Internal Number: 110204-en_US We are seeking a Sr. Research Specialist/Bioinformatics who will be responsible for scientific and administrative activities of a telomere laboratory that has a broad scientific focus spanning molecular and genetic research. The candidate will be…

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Reply to: Re-evaluating evidence for adaptive mutation rate variation

replying to L. Wang et al. Nature doi.org/10.1038/s41586-023-06314-y (2023) Wang and colleagues1 argue that our report2 of lower mutation rates in gene bodies, essential genes and regions marked by H3K4me1 must result from DNA sequencing errors. We appreciate the issues raised by them and by other colleagues3. Although we overlooked…

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The complementarity of DDR, nucleic acids and anti-tumour immunity

Decout, A., Katz, J. D., Venkatraman, S. & Ablasser, A. The cGAS–STING pathway as a therapeutic target in inflammatory diseases. Nat. Rev. Immunol. 21, 548–569 (2021). Article  CAS  PubMed  PubMed Central  Google Scholar  Martincorena, I. & Campbell, P. J. Somatic mutation in cancer and normal cells. Science 349, 1483–1489 (2015)….

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Vasso’s Corner: mRNA, DNA, vector, protein, attenuated, inactivated vaccines: What’s the difference?

Since the COVID-19 pandemic we constantly hear mRNA-, viral vector-, DNA-, protein-, killed- and, live attenuated- based vaccines. What is the difference? They are just different types of vaccine formulations, all with the same end-result, to stimulate an immune response and protect against a specific disease. History of vaccines: The…

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CRISPR Technology Market to Reach US$ 7.72 Billion by 2030:

Burlingame, July 11, 2023 (GLOBE NEWSWIRE) — According to Coherent Market Insights, global CRISPR technology market is generated $2.25 billion in 2022, and is anticipated to generate $7.72 billion by 2030, witnessing a CAGR of 19.2% from 2022 to 2030. The global CRISPR technology market is witnessing strong growth on…

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The Global DNA Synthesizer Market size was valued at 2.8 Bn in 2022

DNA Synthesizer Market DNA Synthesizer Market Report Scope and Research Methodology: The report provides a comprehensive analysis of the global DNA synthesizer market, including the current market size and future growth prospects. It covers key drivers, restraints, and opportunities influencing the market. The report also includes an in-depth analysis of…

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Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer

Baseline characteristics We described the baseline clinical and pathological characteristics of TNAC and LK-TNBC in Supplementary Table 1. Only stage at diagnosis was different between TNAC and LK-TNBC (P = 0.03), while no significant differences were observed in other characteristics, including nuclear grade, histologic grade, Ki-67, and status of (neo)adjuvant treatment. Somatic…

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Mismatch Repair Deficiency Shapes Tumor-Agnostic Use of Immunotherapy

Cancer immunotherapies have transformed the treatment landscape of many tumor types by stimulating the body’s mechanisms of targeting cancer cells. The efficacy of immune checkpoint inhibitors (ICIs) can vary widely between different tumor types based on immunogenicity and other factors—even patients with the same disease may respond very differently to…

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Recent FDA Actions: June 2023

FDA Approves Enfortumab Vedotin Plus Pembrolizumab for Locally Advanced or Metastatic Urothelial Carcinoma The FDA has granted accelerated approval to enfortumab vedotin-ejfv (Padcev) plus pembrolizumab (Keytruda) for patients with locally advanced or metastatic urothelial carcinoma who are not eligible for cisplatin-containing chemotherapy.1 The regulatory decision was supported by data from the…

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Proton and alpha radiation-induced mutational profiles in human cells

Determining proton and helium ion fraction, and irradiating the cell lines The dosage of radiation was determined experimentally in order to achieve between 40 and 50% lethality (corresponding to 50% to 60% clonogenic survival), independently across the two types of particle beams (Fig. 1a,b). Figure 1 Overview of the experimental design….

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Role of RNA splicing mutation

Introduction Non-Hodgkin lymphoma is a heterogeneous group of cancers that starts during immune system differentiation.1 Recent reports show that more than 100 different lymphoma types have been identified.2 These lymphomas originate from cells of the immune system such as B cells, T cells, and dendritic cells. B-cell lymphomas are another…

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Overexpression of SIRT6 alleviates apoptosis and enhances cell viability and monoclonal antibody expression in CHO-K1 cells

Xiao S, Li Q, Jiang J, Huo C, Chen H and Guo M (2023) Rapid Identification of chinese Hamster ovary cell apoptosis and its potential role in process Robustness Assessment. Bioengineering (Basel) 10. doi.org/10.3390/bioengineering10030357 Bryan L, Clynes M and Meleady P (2021) The emerging role of cellular post-translational modifications in…

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Phylogenomic analysis, cryptic species discovery, and DNA barcoding of the genus Cibotium in China based on plastome data

Introduction Traditional Chinese herbal medicine plays an indispensable role in the treatment of multiple diseases in China and other developing countries (Newman et al., 2008). Apart from the traditional usage, many medicinal plants, such as Artemisia annua L. (artemisinin, Tu, 2016), Huperzia javanica (Sw.) C. Y. Yang (Huperzine A, Zangara, 2003;…

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Gene Editing Market has witnessed significant growth, reaching

Gene Editing Market Gene Editing Market Report Scope and Research Methodology The gene editing market report aims to provide a comprehensive analysis of the global gene editing industry, including its current state, growth prospects, key trends, and competitive landscape. The scope of the report encompasses various gene editing technologies, such…

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DNA Polymerase Market to grow at a CAGR of 6.4 percent

Pune, May 25, 2023 (GLOBE NEWSWIRE) — Maximize Market research, a global market research firm has published a competitive intelligence market research report on the “DNA Polymerase Market”. The DNA Polymerase Market size was valued at USD 3.7 Bn in 2022. The total DNA Polymerase Market revenue is expected to…

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KEGG T07277: 120500365

Entry 120500365         CDS       T07277                                  Symbol SRP54 Name (RefSeq) signal recognition particle 54 kDa protein   KO K03106   signal recognition particle subunit SRP54 [EC:3.6.5.4] Organism pmoa  Passer montanus (Eurasian tree sparrow) Pathway pmoa03060   Protein export Brite KEGG Orthology (KO) [BR:pmoa00001] 09120 Genetic Information Processing  09123 Folding, sorting and degradation   03060 Protein export    120500365 (SRP54) 09180 Brite Hierarchies  09183 Protein families: signaling…

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Multiple Factors at Play in the Rise of Early-Onset Colorectal Cancer

My colon cancer patients are getting younger. The diagnoses are happening just as some of these individuals are embarking on their plans for life, while others are in the crucial midst of parenthood. Given this, the tragedy of their cancers feels exponentially greater. This youthful trend in my clinic is…

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CRISPR And Cas Genes Market, Projected to Reach USD11.60 Billion

CRISPR And Cas Genes Market CRISPR And Cas Genes Market Report Scope and Research Methodology The report provides a detailed analysis of the CRISPR And Cas Genes Market dynamics, focusing on regional insights and application industries. It offers valuable information about the market’s market values, drivers, restraints, and research methodology….

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DNA Polymerase Market is poised for significant growth, with

DNA Polymerase Market DNA Polymerase Market Report Scope and Research Methodology The DNA polymerase market report aims to provide a comprehensive analysis of the global market. The report covers various factors that influence the growth of the market, including drivers, restraints, opportunities, and challenges. The report also provides an in-depth…

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Genotyping Market Expected to Reach USD 40.34 Billion by 2029

Genotyping Market Genotyping Market Report Scope and Research Methodology The report provides a holistic view of the market by integrating qualitative and quantitative data. The data was collected through primary and secondary research methods, including surveys, interviews with key industry players, and data analysis of reputable sources. For detail insights…

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Long Read Sequencing Market to reach USD 6520.7 Mn by 2029,

Long Read Sequencing Market According to a new report by MMR, the Long Read Sequencing Market size was valued at USD 1488 Mn. in 2022 and is expected to reach USD 6520.7 Mn. by 2029 at a CAGR of 23.5 percent during the forecast period. Long Read Sequencing Market Report…

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Metagenomics-enabled reverse-genetics assembly and characterization of myotis bat morbillivirus

Ethics declaration Animal study was performed following the Guide for the Care and Use of Laboratory Animals. Animal experiment was approved by the Institutional Animal Care and Use Committee of Colorado State University (protocol number 1090) in advance and conducted in compliance with the Association for the Assessment and Accreditation…

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Carrier Screening Market to hit USD 5.19 Bn by 2029 at a CAGR of 14.6 percent

Carrier Screening Market to hit USD 5.19 Bn by 2029 at a CAGR of 14.6 percent – says Maximize Market Research Dublin, May 02, 2023 (GLOBE NEWSWIRE) — A global Information Technology & Telecommunication research and business-consulting firm, Maximize Market Research, has published a market intelligence report on the “…

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The Future of Endometrial Cancer Treatment Based on Practice-Changing SGO Abstracts

Adding immunotherapy to chemotherapy continues to be the standard treatment method for patients with endometrial cancer, regardless of disease stage, according to John Nakayama, MD. Recent data presented at the Society of Gynecologic Oncology (SGO) Annual Meeting may bring additional combinations to the armamentarium. The phase 3 NRG-GY018 study (NCT03914612)…

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Covid-19 and the marvel of mRNA vaccine: Know how it works

To most people in the world, we millennials in particular, before the year 2020 the idea of pandemics seemed confined to history textbooks and to Hollywood movies. None of us could have had an inkling as to the turn our lives were about to take. Our hubris was soon checked,…

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Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice

Optimizing prime editing systems for HSPCs We previously reported the use of prime editing to correct HBBS by plasmid transfection in HEK293T cells containing the SCD mutation, reaching up to 58% efficiency (Fig. 1a)24. In contrast to HEK293T cells, HSPCs are difficult to transfect with plasmid DNA but are amenable…

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Mitochondrial Inheritance Following Nuclear Transfer: From Cloned Animals to Patients with Mitochondrial Disease

Rojansky R, Cha M-Y, Chan DC (2016) Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. eLife 5:e17896. doi.org/10.7554/eLife.17896 CrossRef  CAS  PubMed  PubMed Central  Google Scholar  Wei W, Pagnamenta AT, Gleadall N et al (2020) Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA…

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A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance

Differential expression of DDR1 between tumor and normal tissue samples To better understand DDR1 expression levels in various cancer types, we first performed a pan-cancer analysis of 33 cancers in the TCGA database. Excluding cancers without corresponding normal samples, significant differences in DDR1 expression were found between tumor and normal…

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DUSP6 is a memory retention feedback regulator of ERK signaling for cellular resilience of human pluripotent stem cells in response to dissociation

Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell doi.org/10.1016/j.cell.2006.07.024 (2006). Article  PubMed  Google Scholar  Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147. doi.org/10.1126/science.282.5391.1145 (1998). Article  ADS  CAS  PubMed  Google…

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National Vaccination Day 2023, Theme, History and More

National Vaccination Day 2023 National Vaccine Day is celebrated on 16 March every year. The COVID-19 and subsequent development of vaccines have made information on vaccines especially relevant for candidates aspiring for various competitive examinations. The idea behind the celebration of National Vaccine Day is to spread awareness and highlight…

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Engineered hypermutation adapts cyanobacterial photosynthesis to combined high light and high temperature stress

Disrupting the natural DNA replication fidelity mechanism to increase mutation rates The high fidelity of genome replication processes in biological cells is ensured by multiple levels of proofreading and repair mechanisms25, including base selection, 3’->5’ exonuclease activity, methyl-directed mismatch repair (MMR), DNA damage repair, translesion DNA synthesis (TLS), etc. (Fig. 1)….

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Machine Learning Algorithm Predicts Efficiency of Prime Editing Insertions

NEW YORK – A team led by researchers at the Wellcome Sanger Institute has come up with a machine learning method for predicting genome editing efficiency when using a CRISPR-Cas9-based approach known as prime editing. The approach relies on prime editors capable of making precise changes to single bases or…

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Phase 3 ASCEMBL Study Demonstrates Superiority of Asciminib in CML-CP

As part of CancerNetwork’s Face-Off video series, Talha Badar, MBBS, MD, assistant professor of oncology, Mayo Clinic, discussed results from the phase 3 ASCEMBL study (NCT03106779) of asciminib (Scemblix) versus bosutinib (Bosulif) in patients with chronic myeloid leukemia in chronic phase (CML-CP) after ≥2 prior tyrosine kinase inhibitors (TKIs). Badar:…

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Pembrolizumab/Chemo Boosts PFS in Advanced/Recurrent Endometrial Cancer

Pembrolizumab plus chemotherapy appears to produce a significant improvement in progression-free survival among patients with advanced or recurrent endometrial cancer. Treatment with pembrolizumab (Keytruda) in combination with chemotherapy yielded a statistically significant and clinically meaningful improvement in progression-free survival (PFS) compared with chemotherapy alone among patients with stage III/IV or…

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Potential Roles of mtDNA Mutations in PCOS-IR

Introduction Polycystic ovary syndrome (PCOS) is the most common endocrine disease occurring during reproductive years. It was a kind of endocrine and metabolic disorders that results in obesity, irregularity of menstruation, OS, hyperinsulinemia, hyperandrogenism, infertility, and sterility.1,2 First identified in 1935, PCOS was also recognized as Stein–Leventhal syndrome.3 Diagnosis of…

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Differential methylation of circRNA m6A in an APP/PS1 Alzheimer’s disease mouse model

Spandidos Publications style Zhang X, Yang S, Han S, Sun Y, Han M, Zheng X, Li F, Wei Y, Wang Y, Bi J, Bi J, et al: Differential methylation of circRNA m6A in an APP/PS1 Alzheimer’s disease mouse model. Mol Med Rep 27: 55, 2023 APA Zhang, X., Yang, S.,…

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05 Postdoctoral Fellowship at Lund University, Scania, Sweden

Lund University, Scania, Sweden invites online Application for various Postdoctoral Fellowship in their different Departments. We are providing a list of Postdoc Fellowship positions available at Lund University, Scania, Sweden. Eligible candidate may Apply as soon as possible.   (01) Postdoctoral Fellowship Position Postdoc Fellowship Position summary/title:  Postdoctoral researcher in…

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Acute phase of ischemia-reperfusion in rats

Introduction Stroke is one of the leading causes of death and disability worldwide, which causes substantial economic and social burdens.1 Ischemic stroke is caused by insufficient blood and oxygen supply to the brain,2 accounting for about 85% of the casualties of stroke patients.3 The concept of treatment for ischemic injury…

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Genetic and chemotherapeutic influences on germline hypermutation

DNM filtering in 100,000 Genomes Project We analysed DNMs called in 13,949 parent–offspring trios from 12,609 families from the rare disease programme of the 100,000 Genomes Project. The rare disease cohort includes individuals with a wide array of diseases, including neurodevelopmental disorders, cardiovascular disorders, renal and urinary tract disorders, ophthalmological…

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Role of CD68 in tumor immunity and prognosis prediction in pan-cancer

Expression of CD68 in pan-cancer First, to fully clarify the expression of CD68 in pan-cancer, we matched the GTEx normal samples with TCGA tumor samples (Fig. 1A). We found that the levels of CD68 were significantly elevated (P < 0.01) in colon adenocarcinoma (COAD), glioblastoma multiforme (GBM), kidney renal clear cell carcinoma (KIRC),…

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Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do not contribute to clinical presentation of acquired fructose malabsorption | BMC Gastroenterology

Fassio F, Facioni MS, Guagnini F. Lactose maldigestion, malabsorption, and intolerance: a comprehensive review with a focus on current management and future perspectives. Nutrients. 2018. doi.org/10.3390/nu10111599. Article  PubMed  PubMed Central  Google Scholar  Gibson PR, Newnham E, Barrett JS, et al. Review article: fructose malabsorption and the bigger picture. Aliment Pharmacol…

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Identification of differentially expressed genes in AF

Defeng Pan,1,&ast; Yufei Zhou,2,&ast; Shengjue Xiao,1,&ast; Yue Hu,3,&ast; Chunyan Huan,1 Qi Wu,1 Xiaotong Wang,1 Qinyuan Pan,1 Jie Liu,1 Hong Zhu1 1Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People’s Republic of China; 2Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of…

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Mutational Analysis of Mitochondrial tRNA Genes

Introduction Diabetes is a very complex disease characterized by the presence of chronic hyperglycemia. Clinically, insulin-dependent type 1 and non-insulin-dependent type 2 are the main types of diabetes. Among them, type 2 diabetes mellitus (T2DM, [MIM125853]) is a common endocrine disorder affecting approximately 10% of adult population.1 In most cases,…

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Adjunct Faculty: Bioinformatics – Intro to Bioinformatics, Practical Computer Concepts for job with Johns Hopkins University

Johns Hopkins University Advanced Academic Programs Biotechnology Program Adjunct Faculty: Bioinformatics (Introduction to Bioinformatics, Practical Computer Concepts for Bioinformatics, Metagenomics) Institution Description: The Advanced Academic Programs (AAP) is a division of the Krieger School of Arts and Sciences at the Johns Hopkins University (JHU). As the nation’s oldest and one…

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Prevalence and Molecular Characteristics Based on Whole Genome Sequenc

Introduction Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the top 10 causes of death worldwide and the leading cause of death from a single infectious agent (ranking above HIV/AIDS).1 In 2020, World Health Organization (WHO) reported that 7.1 million people with tuberculosis were newly diagnosed and notified in 2019,…

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