Tag: mol

Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance

1 Introduction Lung cancer is the leading cause of cancer-related deaths worldwide, with adenocarcinoma as the most common histological subtype.1 In recent years, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib (first generation) and osimertinib (third generation), have been widely used for lung adenocarcinoma patients harboring activated EGFR…

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CRISPR-Created Model of Fabry Disease Sparks New Insights

Kidney organoids designed with the same mutation as that present in Fabry disease can help investigators better understand how the disease functions, authors suggested. A new report makes the case that stem-cell-derived kidney organoids can provide a meaningful model for understanding how Fabry disease affects the body and for developing…

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The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection | BMC Genomic Data

1. Taylor RW, Turnbull DM. Mitochondrial DNA mutations in human disease [Internet]. Vol. 6, Nature Reviews Genetics. Europe PMC Funders; 2005 [cited 2020 Aug 21]. p. 389–402. Available from: /pmc/articles/PMC1762815/?report=abstract. 2. Kabunga P, Lau AK, Phan K, Puranik R, Liang C, Davis RL, Sue CM, Sy RW Systematic review of…

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The Chloranthus sessilifolius genome provides insight into early diversification of angiosperms

1. The Plant List. The Plant List—A Working List of All Plant Species (Royal Botanic Gardens, Kew and Missouri Botanical Garden, 2019). www.theplantlist.org/. Retrieved 20 Aug 2019. 2. Christenhusz, M. J. M. & Byng, J. W. The number of known plants species in the world and its annual increase. Phytotaxa…

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Escherichia coli K-12 substr. MG1655 EC 4.2.1.150

BioCyc ID: RXN-11667 EC Number: 4.2.1.150 Enzymes and Genes: 3-hydroxyacyl-CoA dehydrogenase FadJ: fadJ multifunctional enoyl-CoA hydratase, 3-hydroxyacyl-CoA epimerase, Δ3–cis– Δ2–trans-enoyl-CoA isomerase, L-3-hydroxyacyl-CoA dehydrogenase: fadB In Pathway: oleate β-oxidation Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC entry. The reaction direction shown is…

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Bug#1000579: rdkit: autopkgtest regression

Source: rdkit Version: 202103.5-1 X-Debbugs-CC: debi…@lists.debian.org Severity: serious User: debi…@lists.debian.org Usertags: regression Dear maintainer(s), With a recent upload of rdkit the autopkgtest of rdkit fails in testing when that autopkgtest is run with the binary packages of rdkit from unstable. It passes when run with only packages from testing. In…

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[lammps-users] CPU and and running lammps with KOKKOS – LAMMPS Mailing List Mirror

Dear developper,I have installed lammps stable version from 29 sept 2021 on a 2 processor x 16 cores each intel Gold processor (Sky Lake architecture) 192 Go Memory.I am using lammps with kokkos (built with …/cmake/presets/kokkos-openmp.cmake) and I am facing the following problem.When running a simulation withmpirun -np 4 lmp…

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High-Throughput RNA Sequencing Reveals the Effect of NB-UVB

Introduction Psoriasis vulgaris, major chronic immune-mediated skin disease, affects 1–3% of the adult population worldwide.1 Psoriasis is one of the major complex skin diseases that is significantly linked to genetic predisposition, major histocompatibility alleles, and environmental factors.2 Over the past few years, the cellular and molecular contributions to psoriasis were…

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The earliest Denisovans and their cultural adaptation

1. Reich, D. et al. Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature 468, 1053–1060 (2010). CAS  PubMed  PubMed Central  Google Scholar  2. Krause, J. et al. The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature 464, 894–897 (2010). CAS  PubMed …

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Chromosome-scale genome assembly of the high royal jelly-producing honeybees

1. Knecht, D. & Kaatz, H. H. Patterns of larval food production by hypopharyngeal glands in adult worker honey bees. Apidologie 21, 457–468, doi.org/10.1051/apido:19900507 (1990). Article  Google Scholar  2. Kamakura, M. Royalactin induces queen differentiation in honeybees. Nature 473, 478–483, doi.org/10.1038/nature10093 (2011). ADS  CAS  Article  PubMed  Google Scholar  3. Ramadan,…

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Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection

1. Latgé, J. P. and Chamilos, G. Aspergillus fumigatus and Aspergillosis in 2019. Clin. Microbiol. Rev. doi.org/10.1128/CMR.00140-18 (2019). 2. Invasive Aspergillosis. LIFE www.life-worldwide.org/fungal-diseases/invasive-aspergillosis (2020). 3. Harrison, N. et al. Incidence and characteristics of invasive fungal diseases in allogeneic hematopoietic stem cell transplant recipients: a retrospective cohort study. BMC Infect. Dis….

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KEGG COMPOUND: C15365

KEGG COMPOUND: C15365     COMPOUND: C15365 Help Entry C15365                      Compound                                Name 4-Pregnene-16alpha,21-diol-3,20-dione;16alpha,21-Dihydroxypregn-4-ene-3,20-dione Formula C21H30O4 Exact mass 346.2144 Mol weight 346.4605 Structure Mol fileKCF fileDB search Other DBs KCF data Show ATOM        25            1   C1y C    26.6870  -20.7306            2   C1y C    25.5683  -20.0954            3   C1y C    27.7943  -20.0837            4   C1x C    26.6637  -22.0009            5   C1z C    24.4728  -20.7423            6   C1x C    25.5624  -18.8134            7   C1z C    27.7943  -18.8018            8   C1x C    30.0204  -20.0896            9   C1x C    25.5800  -22.6419            10  C2y C    24.4728  -22.0126            11  C1x C    23.3715  -20.1130            12  C1a C    24.4552  -19.2680            13  C1x C    26.6754  -18.1667            14  C1y C    28.9189  -18.1608            15  C1y C    30.0261  -18.8077            16  C2x C    23.3715  -22.6536            17  C1x C    22.2876  -20.7423            18  C5a C    28.9189  -16.9021            19  C5x C    22.2876  -22.0126            20  C1b C    30.0087  -16.2845            21  C1a…

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KEGG COMPOUND: C12206

KEGG COMPOUND: C12206     COMPOUND: C12206 Help Entry C12206                      Compound                                Name Formula C9H10O3 Exact mass 166.063 Mol weight 166.1739 Structure Mol fileKCF fileDB search Reaction Pathway map00940   Phenylpropanoid biosynthesis map01110   Biosynthesis of secondary metabolites Enzyme Brite Phytochemical compounds [BR:br08003] Phenylpropanoids  Monolignols   Caffeate derivatives    C12206  Caffeyl alcohol BRITE hierarchy Other DBs KCF data Show ATOM        12            1   C8y C    28.0700  -19.5300            2   C8x C    28.0700  -20.9300            3   C8x…

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Diagnostic markers of AIDS combined with TM infection

Introduction The prevalence of Human immunodeficiency virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is still a public health problem that threatens the health of all human beings. According to the latest report of the World Health Organization, in the end of 2019, there were 38 million patients with human immunodeficiency virus/acquired immunodeficiency…

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ecDNA hubs drive cooperative intermolecular oncogene expression

1. Wu, S. et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature 575, 699–703 (2019). 2. Gorkin, D. U., Leung, D. & Ren, B. The 3D genome in transcriptional regulation and pluripotency. Cell Stem Cell 14, 762–775 (2014). CAS  PubMed  PubMed Central  Google Scholar  3. Zheng, H….

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The genome of the diatom Chaetoceros tenuissimus carries an ancient integrated fragment of an extant virus

1. Field, C. B., Behrenfeld, M. J., Randerson, J. T. & Falkowski, P. Primary production of the biosphere: Integrating terrestrial and oceanic components. Science 281, 237–240 (1998). ADS  CAS  PubMed  Google Scholar  2. Nelson, D. M., Tréguer, P., Brzezinski, M. A., Leynaert, A. & Quéguiner, B. Production and dissolution of…

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The genome of the diatom Chaetoceros tenuissimus carries an ancient integrated fragment of an extant virus

1. Field, C. B., Behrenfeld, M. J., Randerson, J. T. & Falkowski, P. Primary production of the biosphere: Integrating terrestrial and oceanic components. Science 281, 237–240 (1998). ADS  CAS  PubMed  Google Scholar  2. Nelson, D. M., Tréguer, P., Brzezinski, M. A., Leynaert, A. & Quéguiner, B. Production and dissolution of…

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Effect of the cholesterol on electroporation of planar lipid bilayer

Available online 23 November 2021, 108004 doi.org/10.1016/j.bioelechem.2021.108004Get rights and content Highlights: • Planar lipid bilayers were prepared from POPC lipids with addition of cholesterol. • Capacitance, breakdown voltage and lifetime of planar lipid bilayers were measured. • Obtained data was fitted to a strength-duration curve for further analysis. • Addition…

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DNA sequencing: an overview of solid-state and biological nanopore-based methods

Adams J, Jeppesen P, Sanger F, Barrell B (1969) Nucleotide sequence from the coat protein cistron of R17 bacteriophage RNA. Nature 223:1009–1014. doi.org/10.1038/2231009a0 CAS  Article  PubMed  Google Scholar  Akahori R, Yanagi I, Goto Y, Harada K, Yokoi T, Takeda K-I (2017) Discrimination of three types of homopolymers in single-stranded DNA…

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Genotyping-in-Thousands by sequencing of archival fish scales reveals maintenance of genetic variation following a severe demographic contraction in kokanee salmon

1. Wandeler, P., Hoeck, P. E. & Keller, L. F. Back to the future: Museum specimens in population genetics. Trends Ecol. Evol. 22, 634–642 (2007). PubMed  Google Scholar  2. Bi, K. et al. Unlocking the vault: Next-generation museum population genomics. Mol. Ecol. 22, 6018–6032 (2013). CAS  PubMed  PubMed Central  Google…

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WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circula

Introduction Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder in women of childbearing age.1 PCOS patients are typically characterized by androgen excess, polycystic ovaries and anovulation, and are often accompanied by insulin resistance and obesity.2 Consequently, patients with this syndrome not only suffer from infertility,3 but also have…

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Genome sequencing of the multicellular alga Astrephomene provides insights into convergent evolution of germ-soma differentiation

1. Smith, J. M. & Száthmary, E. The Major Transitions in Evolution (Freeman, 1995). Google Scholar  2. Queller, D. C. Relatedness and the fraternal major transitions. Philos. Trans. R. Soc. Lond. B Biol. Sci. 355, 1647–1655 (2000). CAS  PubMed  PubMed Central  Google Scholar  3. Grosberg, R. K. & Strathmann, R….

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Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells | Stem Cell Research & Therapy

1. Shimasaki N, Jain A, Campana D. NK cells for cancer immunotherapy. Nat Rev Drug Discov. 2020;19(3):200–18. CAS  PubMed  Google Scholar  2. Myers JA, Miller JS. Exploring the NK cell platform for cancer immunotherapy. Nat Rev Clin Oncol. 2021;18(2):85–100. PubMed  Google Scholar  3. Cantoni C, Wurzer H, Thomas C, Vitale…

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Bioinformatician position in Biochemistry, Bioinformatics, 3D genomics – NKI, Netherlands

The Netherlands Cancer Institute (NKI) in Amsterdam is a Comprehensive Cancer Centre combining a hospital and research laboratories in a single independent organization. The research group of Benjamin Rowland is part of the Division of Cell Biology, and is specialized in chromosome biology. Support us by Sharing! ADVERTISEMENTScroll Down for…

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Electroporation: Technology and Science | SpringerLink

Marie-Pierre Rols Muriel Golzio Justin Teissié Chapter First Online: 21 November 2021 Abstract Enormous progress has been made in pulsed electric field-based therapies since the first reports describing the occurrence of electric field-induced transient pores in phospholipid bilayer vesicles. The term electroporation took some time to anchor within the vocabulary of the scientific…

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Electroporation: Technology and Science | SpringerLink

Marie-Pierre Rols Muriel Golzio Justin Teissié Chapter First Online: 21 November 2021 Abstract Enormous progress has been made in pulsed electric field-based therapies since the first reports describing the occurrence of electric field-induced transient pores in phospholipid bilayer vesicles. The term electroporation took some time to anchor within the vocabulary of the scientific…

Continue Reading Electroporation: Technology and Science | SpringerLink

KEGG COMPOUND: C14321

KEGG COMPOUND: C14321     COMPOUND: C14321 Help Entry C14321                      Compound                                Name Benzo[k]fluoranthene;11,12-Benzofluoranthene Formula C20H12 Exact mass 252.0939 Mol weight 252.3093 Structure Mol fileKCF fileDB search Other DBs KCF data Show ATOM        20            1   C8x C    23.5937  -16.9983            2   C8x C    23.5937  -18.3568            3   C8x C    24.7702  -19.0361            4   C8y C    25.9468  -18.3568            5   C8y C    25.9468  -16.9983            6   C8x C    24.7702  -16.3190            7   C8x C    27.1233  -19.0361            8   C8y C    28.2998  -18.3568            9   C8y C    28.2998  -16.9983            10  C8x C    27.1233  -16.3190            11  C8y C    30.6529  -18.3568            12  C8y C    30.6529  -16.9983            13  C8y C    29.4764  -16.3190            14  C8y C    31.8294  -16.3190            15  C8x C    31.8294  -14.9604            16  C8x C    30.6529  -14.2811            17  C8x C    29.4764  -14.9604            18  C8x C    31.8294  -19.0361            19  C8x C    33.0061  -18.3568            20  C8x C    33.0061  -16.9983BOND        24            1     1   2…

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KEGG COMPOUND: C14321

KEGG COMPOUND: C14321     COMPOUND: C14321 Help Entry C14321                      Compound                                Name Benzo[k]fluoranthene;11,12-Benzofluoranthene Formula C20H12 Exact mass 252.0939 Mol weight 252.3093 Structure Mol fileKCF fileDB search Other DBs KCF data Show ATOM        20            1   C8x C    23.5937  -16.9983            2   C8x C    23.5937  -18.3568            3   C8x C    24.7702  -19.0361            4   C8y C    25.9468  -18.3568            5   C8y C    25.9468  -16.9983            6   C8x C    24.7702  -16.3190            7   C8x C    27.1233  -19.0361            8   C8y C    28.2998  -18.3568            9   C8y C    28.2998  -16.9983            10  C8x C    27.1233  -16.3190            11  C8y C    30.6529  -18.3568            12  C8y C    30.6529  -16.9983            13  C8y C    29.4764  -16.3190            14  C8y C    31.8294  -16.3190            15  C8x C    31.8294  -14.9604            16  C8x C    30.6529  -14.2811            17  C8x C    29.4764  -14.9604            18  C8x C    31.8294  -19.0361            19  C8x C    33.0061  -18.3568            20  C8x C    33.0061  -16.9983BOND        24            1     1   2…

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KEGG COMPOUND: C05629

KEGG COMPOUND: C05629     COMPOUND: C05629 Help Entry C05629                      Compound                                Name Phenylpropanoate;3-Phenylpropanoate;3-Phenyl-propionic acid;3-Phenylpropanoic acid;3-Phenylpropionic acid Formula C9H10O2 Exact mass 150.0681 Mol weight 150.1745 Structure Mol fileKCF fileDB search Reaction Pathway map01120   Microbial metabolism in diverse environments map01220   Degradation of aromatic compounds Enzyme Other DBs KCF data Show ATOM        11            1   C8y C    28.1642  -20.9195            2   C1b C    28.1577  -19.5290            3   C8x C    26.9594  -21.6180            4   C8x…

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KEGG COMPOUND: C19566

KEGG COMPOUND: C19566     COMPOUND: C19566 Help Entry C19566                      Compound                                Name 4-Hydroxy-4-(methylnitrosoamino)-1-(3-pyridinyl)-1-butanone Formula C10H13N3O3 Exact mass 223.0957 Mol weight 223.2285 Structure Mol fileKCF fileDB search Reaction Pathway map00980   Metabolism of xenobiotics by cytochrome P450 map05204   Chemical carcinogenesis – DNA adducts Enzyme Other DBs KCF data Show ATOM        16            1   N5x N    18.0419  -19.7673            2   C8x C    18.0419  -21.1643            3   C8x C    19.2517  -21.8628            4   C8x C    20.4616  -21.1643            5   C8y…

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circRNA-miRNA-mRNA regulatory network in atrial fibrillation

Introduction Atrial fibrillation (AF) is the most common type of arrhythmia in clinical practice, with global prevalence continuing to increase primarily with age.1 In China, 6.5 persons out of every thousand suffer from AF, and there are about 3.9 million patients with AF who are over 60 years old, but…

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Construction of circRNA-related ceRNA networks in longissimus dorsi muscle of Queshan Black and Large White pigs

Arcinas C, Tan W, Fang W, Desai TP, Teh DCS, Degirmenci U, Xu D, Foo R, Sun L (2019) Adipose circular RNAs exhibit dynamic regulation in obesity and functional role in adipogenesis. Nat Metab 1:16. doi.org/10.1038/s42255-019-0078-z CAS  Article  Google Scholar  Aronoff SL, Berkowitz K, Shreiner B, Want L (2004) Glucose…

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KEGG COMPOUND: C21461

KEGG COMPOUND: C21461     COMPOUND: C21461 Help Entry C21461                      Compound                                Name Kdo2-lipid A 1-(2-aminoethyl diphosphate) Formula C112H208N3O42P3 Exact mass 2360.3445 Mol weight 2361.7661 Structure Mol fileKCF fileDB search Reaction Pathway map00540   Lipopolysaccharide biosynthesis Enzyme Other DBs KCF data Show ATOM        160            1   C1y C    15.2440  -13.5657            2   C1y C    16.4327  -12.8664            3   C1y C    14.0552  -12.8664            4   O7a O    15.2440  -14.9642            5   C1y C    16.4327  -11.4679            6   N1b N    17.6215  -13.5657            7   C1y C    14.0552  -11.4679            8   O2b O    12.7966  -13.5657            9   C7a C    14.0552  -15.6635            10  O2x O    15.2440  -10.7686            11  O2a O    17.6215  -10.7686            12  C5a…

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KEGG COMPOUND: C00144

KEGG COMPOUND: C00144     COMPOUND: C00144 Help Entry C00144                      Compound                                Name GMP;Guanosine 5′-phosphate;Guanosine monophosphate;Guanosine 5′-monophosphate;Guanylic acid Formula C10H14N5O8P Exact mass 363.058 Mol weight 363.2206 Structure Mol fileKCF fileDB search Reaction Pathway map01060   Biosynthesis of plant secondary metabolites map01065   Biosynthesis of alkaloids derived from histidine and purine Module M00050   Guanine ribonucleotide biosynthesis,…

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Zhang Jin’s group reported that rRNA biogenesis regulates the fate transition of mouse ES-2C-like cells

On November 9, 2021, the Stem Cell and Regenerative Medicine Center of the Department of Basic Medicine, Zhejiang University School of Medicine/The First Affiliated Hospital of Zhejiang University School of Medicine/Zhejiang Liangzhu Laboratory Zhang Jin’s research group published a titled ” rRNA Biogenesis ” in Nature Communications . Regulates Mouse…

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CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity

1. Chapman, N. M., Boothby, M. R. & Chi, H. Metabolic coordination of T cell quiescence and activation. Nat. Rev. Immunol. 20, 55–70 (2020). CAS  PubMed  Google Scholar  2. Kim, J. & Guan, K. L. mTOR as a central hub of nutrient signalling and cell growth. Nat. Cell Biol. 21,…

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Interploidy gene flow involving the sexual-asexual cycle facilitates the diversification of gynogenetic triploid Carassius fish

1. Muller, H. J. The relation of recombination to mutational advance. Mutat. Res. Mol. Mech. Mutagen. 1, 2–9 (1964). Google Scholar  2. Maynard Smith, J. The Evolution of Sex (Cambridge University Press, 1978). Google Scholar  3. Avise, J. C. Clonality (Oxford University Press, 2008). Google Scholar  4. Hamilton, W. D.,…

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Escherichia coli K-12 substr. MG1655

Escherichia coli K-12 substr. MG1655 Escherichia coli K-12 substr. MG1655 EC 2.7.1.11 — 6-phosphofructokinase Synonyms: phosphohexokinase, phosphofructokinase I, phosphofructokinase (phosphorylating), 6-phosphofructose 1-kinase, ATP-dependent phosphofructokinase, D-fructose-6-phosphate 1-phosphotransferase, fructose 6-phosphate kinase, fructose 6-phosphokinase, nucleotide triphosphate-dependent phosphofructokinase, phospho-1,6-fructokinase, PFK Systematic Name: ATP:D-fructose-6-phosphate 1-phosphotransferase Unification Links: BRENDA:2.7.1.11, ENZYME:2.7.1.11, IUBMB-ExplorEnz:2.7.1.11 Reaction: β-D-fructofuranose 6-phosphate + ATP…

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The mtDNA Control Region Variability of Microtus rossiaemeridionalis (Rodentia, Arvicolini) from Two Invasive Populations of the Russian Far East

1 Hobbs, R.J., Arico, S., Aronson, J., et al., Novel ecosystems: theoretical and management aspects of the new ecological world order, Global Ecol. Biogeography, 2006, vol. 15, pp. 1–7. doi.org/10.1111/j.1466-822x.2006.00212.x Article  Google Scholar  2 Bellard, C., Cassey, P., and Blackburn, T.M., Alien species as a driver of recent extinctions, Biol….

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Drug resistance mutations & genetic diversity of HIV1 in ART

Introduction At the end of 2018, 19.5 million people living with HIV were accessing ART globally.1 However, virological failure and development of drug resistance are becoming a bottleneck for the success of ART program. A global study involving 36 countries and 1926 patients with treatment failure from 1998–2015 reported that…

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Single cell genomics reveals plastid-lacking Picozoa are close relatives of red algae

1. Strassert, J. F. H., Irisarri, I., Williams, T. A. & Burki, F. A molecular timescale for eukaryote evolution with implications for the origin of red algal-derived plastids. Nat. Commun. 12, 1879 (2021). ADS  CAS  PubMed  PubMed Central  Google Scholar  2. Burki, F., Roger, A. J., Brown, M. W. &…

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iPSC-Derived Renal Organoid Xenografts Shine a Light on Rare Human Kidney Disease Mechanisms In Vivo

One of the areas of interest in our laboratory is the study of diseases that cause tissue degeneration. Tuberous Sclerosis Complex (TSC) is a multi-system incurable disease affecting approximately 1:7000 live births, that is caused by inactivating mutations in the genes Tuberous Sclerosis Complex 1 or 2 (TSC1, TSC2, respectively)1….

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Precision Oncology: Advancing the Development of Liquid Biopsy-Based Diagnostics with NGS

Precision oncology leverages molecular information about cancer to personalize therapy and improve outcomes. The discovery and development of relevant biomarkers is a prerequisite to fulfillment of the promise of precision oncology, but the challenge for researchers is that clinically actionable mutations occur at very low frequency and sourcing biospecimens with…

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Transcriptome Sequencing Explores the Mechanism of Baicalin on Bone Ca

Introduction With the continuous improvement of cancer treatment technology, the 3-year and 5-year survival rates of cancer patients have been greatly improved. However, cancer still cause pain to the patients, which seriously affects their quality of life. This is because in many common cancers, tumors can easily metastase to the…

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16S rRNA Gene Sequence Identification of Cultivable-Bacterioplankton Between Ambient Water and Gastrointestinal Tract (GIT) of Resident Teleost

1. FAO (2016) World aquaculture production by species groups. In FAO Yearbook. Fish Aquac Stat 2014:52–53 Google Scholar  2. Chuah L, Effarizah ME, Goni AM, Rusul G (2016) Antibiotic application and emergence of multiple antibiotic resistance (MAR) in global catfish aquaculture. Curr Environ Health Rep 3:118–127 CAS  Article  Google Scholar …

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KEGG COMPOUND: C01585

KEGG COMPOUND: C01585     COMPOUND: C01585 Help Entry C01585                      Compound                                Name Hexanoic acid;Hexanoate;Hexylic acid;n-Caproic acid Formula C6H12O2 Exact mass 116.0837 Mol weight 116.1583 Structure Mol fileKCF fileDB search Reaction Enzyme Brite Compounds with biological roles [BR:br08001] Organic acids  Carboxylic acids   Monocarboxylic acids    C01585  Capronate; Hexanoate Lipids  Fatty acids   Saturated fatty acids    C01585  Caproic acid (6:0)Lipids [BR:br08002] FA  Fatty acyls  FA01 Fatty Acids and Conjugates   FA0101…

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KEGG COMPOUND: C01585

KEGG COMPOUND: C01585     COMPOUND: C01585 Help Entry C01585                      Compound                                Name Hexanoic acid;Hexanoate;Hexylic acid;n-Caproic acid Formula C6H12O2 Exact mass 116.0837 Mol weight 116.1583 Structure Mol fileKCF fileDB search Reaction Enzyme Brite Compounds with biological roles [BR:br08001] Organic acids  Carboxylic acids   Monocarboxylic acids    C01585  Capronate; Hexanoate Lipids  Fatty acids   Saturated fatty acids    C01585  Caproic acid (6:0)Lipids [BR:br08002] FA  Fatty acyls  FA01 Fatty Acids and Conjugates   FA0101…

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KEGG COMPOUND: C06032

KEGG COMPOUND: C06032     COMPOUND: C06032 Help Entry C06032                      Compound                                Name D-erythro-3-Methylmalate;(2R,3S)-3-Methylmalate Formula C5H8O5 Exact mass 148.0372 Mol weight 148.114 Structure Mol fileKCF fileDB search Reaction Pathway map00290   Valine, leucine and isoleucine biosynthesis map00660   C5-Branched dibasic acid metabolism map01210   2-Oxocarboxylic acid metabolism Module M00535   Isoleucine biosynthesis, pyruvate => 2-oxobutanoate Enzyme Other…

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sed – Delete records for which multiple pattern conditional s across columns awk

I have a file that looks like NC_042565.1 RefSeq region 1 114882317 . + . ID=NC_042565.1:1..114882317;Dbxref=taxon:299123;Name=1;chromosome=1;dev-stage=adult;gbkey=Src;genome=chromosome;isolate=Mets1;mol_type=genomic DNA;sex=male;sub-species=domestica;tissue-type=blood NC_042565.1 Gnomon gene 21625 41521 . – . ID=gene-LCMT2;Dbxref=GeneID:110474964;Name=LCMT2;gbkey=Gene;gene=LCMT2;gene_biotype=protein_coding NC_042565.1 Gnomon mRNA 21625 41521 . – . ID=rna-XM_021538777.2;Parent=gene-LCMT2;Dbxref=GeneID:110474964,Genbank:XM_021538777.2;Name=XM_021538777.2;gbkey=mRNA;gene=LCMT2;model_evidence=Supporting evidence includes similarity to: 2 ESTs%2C 9 Proteins%2C and 100%25 coverage of the annotated genomic…

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circRNA is a potential target for cardiovascular diseases treatment

1. Li M, Ding W, Tariq MA, Chang W, Zhang X, Xu W, Hou L, Wang Y, Wang J (2018) A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p. Theranostics 8:5855–5869. doi.org/10.7150/thno.27285 Article  PubMed  PubMed Central  CAS  Google Scholar  2. Karra R, Poss KD (2017) Redirecting…

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Age- and gender-independent association of XRCC1 Arg399Gln

Introduction Chronic myeloid leukemia (CML) is a member of myeloproliferative neoplasms characterized by the acquired reciprocal chromosomal translocation, t(9;22) (q34; q11) which occurs as a result of translocation of ABL1 (Abelson murine leukemia) gene from chromosome 9 and its fusion with the BCR (breakpoint cluster region) gene on chromosome 22.1…

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The AlphaFold database of protein structures: a biologist’s guide

Review doi: 10.1016/j.jmb.2021.167336. Online ahead of print. Affiliations Expand Affiliation 1 Centre for Integrative System Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. Item in Clipboard Review Alessia David et al. J Mol Biol. 2021. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1016/j.jmb.2021.167336….

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E7-Targeted Nanotherapeutics for Key HPV Afflicted Cervical Lesions by

Introduction Cervical cancer remains the leading cause of gynecological tumor-related mortality worldwide and the second most common malignancy in women, with 570,000 women diagnosed with cervical cancer and 311,000 dying from the disease each year.1–3 Persistent HR-HPV infection is the main cause of cervical cancer,4 with HPV16 and HPV18 causing…

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Organelle DNA sequence data provide new insights into the maternal and paternal lineages of Musa species germplasms

Argent GCG (1976) The wild bananas of Papua new Guinea. Notes Roy Bot Gard Edinb 35:77–114 Google Scholar  Baker JG (1893) A synopsis of the genera and species of Musaceae. Ann Bot 7:189–229. doi.org/10.1093/aob/os-7.2.189 Article  Google Scholar  Barrett CF, Specht CD, Leebens-Mack J, Stevenson DW, Zomlefer WB, Davis JI (2014)…

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Primer Design for the Analysis of Closely Related Species: Application of Noncoding mtDNA and cpDNA Sequences

doi: 10.1007/978-1-0716-1799-1_6. Affiliations Expand Affiliations 1 Institute of Biology, University of Szczecin, Szczecin, Poland. lidia.skuza@usz.edu.pl. 2 The Centre for Molecular Biology and Biotechnology, University of Szczecin, Szczecin, Poland. lidia.skuza@usz.edu.pl. Item in Clipboard Lidia Skuza. Methods Mol Biol. 2022. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1007/978-1-0716-1799-1_6. Affiliations 1…

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Pyrosequencing Primer Design for Forensic Biology Applications

doi: 10.1007/978-1-0716-1799-1_17. Affiliations Expand Affiliation 1 TU Human Remains Identification Laboratory (THRIL), Chemistry Department, Forensic Science Program, Towson University, Towson, MD, USA. kmelkins@towson.edu. Item in Clipboard Kelly M Elkins. Methods Mol Biol. 2022. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1007/978-1-0716-1799-1_17. Affiliation 1 TU Human Remains Identification Laboratory…

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Subscript a title in a Graph (ggplot2) with label of another file

See if this can give you some idea. Using math expression in base R seems to work for ggplot titles.,Making statements based on opinion; back them up with references or personal experience.,Asking for help, clarification, or responding to other answers.,Connect and share knowledge within a single location that is structured…

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AutoDock Vina Gives Wildly Different Results From Different Simulations Using Same Parameters

AutoDock Vina Gives Wildly Different Results From Different Simulations Using Same Parameters 0 Hello everyone, When I run multiple Autodock Vina independent simulations (at exhaustivness of 100) on the SAME protein and the SAME ligand using the exact SAME parameters but with different random seeds I get different results. Each…

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Bioinformatic Tools for the Analysis and Prediction of ncRNA Interactions

Review . 2021 Oct 22;22(21):11397. doi: 10.3390/ijms222111397. Affiliations Expand Affiliations 1 Bioinformatics and Systems Biology Group, Universidad Nacional de Colombia, Bogotá 111221, Colombia. 2 Centro de Investigaciones en Microbiología y Biotecnología-UR (CIMBIUR), Facultad de Ciencias Naturales, Universidad del Rosario, Bogotá 111221, Colombia. 3 Grupo de Investigación en Biología del Cáncer,…

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European Bioinformatics Institute %257c Embl Ebi Contact Us

Listing Results European Bioinformatics Institute %257c Embl Ebi Contact Us Contact us < European Bioinformatics Institute 5 hours ago Visit EMBL–EBI. The Wellcome Genome Campus is located 10 miles (16 km) south of Cambridge, alongside the village of Hinxton, 30km from London Stansted airport. We are served by two local…

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FGFR2-IIIb Expression by Immunohistochemistry Has High Specificity in Cholangiocarcinoma with FGFR2 Genomic Alterations

1. Ross JS, Wang K, Javle MM et al. Comprehensive genomic profiling of biliary tract cancers to reveal tumor-specific differences and frequency of clinically relevant genomic alterations. J Clin Oncol 2015;33:40009. doi.org/10.1200/jco.2015.33.15_suppl.4009. Article  Google Scholar  2. Goyal L, Govindan A, Sheth RA et al. Prognosis and clinicopathologic features of patients…

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Biopython download nucleotide records without sequences (or skip huge sequences)

I am trying to download information from NCBI Entrez databases (nucleotide), using Biopython package. I don’t need molecular data at all. I just want to check the textual information about certain records, to see references, authors, journals, and information about voucher specimens from which the genome sample was extracted. My…

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Hill Discusses Systemic Therapy for Relapsed/Refractory DLBCL

Eleven months after completing therapy for diffuse large B-cell lymphoma, a 43-year-old patients reported fever, night sweats, and back pain, and a palpable lymph node was discovered in her left groin. During a Targeted Oncology Case-Based Roundtable event, Brian T. Hill, MD, PhD, director, Lymphoid Malignancies Program, staff physician, Department…

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Ameliorating Effect of Umbilical Cord Mesenchymal Stem Cells in a Human Induced Pluripotent Stem Cell Model of Dravet Syndrome

This article was originally published here Mol Neurobiol. 2021 Nov 11. doi: 10.1007/s12035-021-02633-1. Online ahead of print. ABSTRACT Dravet syndrome (DS) is a form of severe childhood-onset refractory epilepsy typically caused by a heterozygous loss-of-function mutation. DS patient-derived induced pluripotent stem cells (iPSCs) are appropriate human cells for exploring disease…

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Genome of the estuarine oyster provides insights into climate impact and adaptive plasticity

1. Hoegh-Guldberg, O. & Bruno, J. F. The impact of climate change on the world’s marine ecosystems. Science 328, 1523–1528 (2010). CAS  PubMed  Google Scholar  2. Chou, C. et al. Increase in the range between wet and dry season precipitation. Nat. Geosci. 6, 263–267 (2013). CAS  Google Scholar  3. Li,…

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Frontiers | Accelerating Complete Phytoplasma Genome Assembly by Immunoprecipitation-Based Enrichment and MinION-Based DNA Sequencing for Comparative Analyses

Introduction Phytoplasmas are wall-less bacterial pathogens that are known to infect numerous plant species and lead to significant agricultural losses (Gurr et al., 2016; Kumari et al., 2019; Pierro et al., 2019). They are parasitic bacteria multiplying exclusively in phloem sieve elements and are transmitted between plants by phloem-feeding insects…

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Perfect and imperfect views of ultraconserved sequences

1. Lander, E. S. et al. Initial sequencing and analysis of the human genome. Nature 409, 860–921 (2001). CAS  PubMed  Google Scholar  2. International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 431, 931–945 (2004). Google Scholar  3. Mouse Genome Sequencing Consortium. et al. Initial…

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Gromacs: gmx::LegacyMdrunOptions Class Reference

This class provides the same command-line option functionality to both CLI and API sessions. This class should not exist, but is necessary now to introduce support for the CLI and API without duplicating code. It should be eliminated following the TODOs below. Warning Instances provide lifetime scope for members that…

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Assessment of CircRNA Expression Profiles and Potential Functions in Brown Adipogenesis

doi: 10.3389/fgene.2021.769690. eCollection 2021. Affiliations Expand Affiliations 1 Department of Biotechnology, College of Life Sciences, Xinyang Normal University, Xinyang, China. 2 Institute of Animal Science and Veterinary Medicine, Hainan Academy of Agricultural Sciences, Haikou, China. 3 Institute for Conservation and Utilization of Agro-Bioresources in Dabie Mountains, Xinyang Normal University, Xinyang,…

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Diverse alterations associated with resistance to KRAS(G12C) inhibition

1. Ostrem, J. M., Peters, U., Sos, M. L., Wells, J. A. & Shokat, K. M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503, 548–551 (2013). ADS  CAS  Article  Google Scholar  2. Lito, P., Solomon, M., Li, L. S., Hansen, R. & Rosen, N. Allele-specific inhibitors inactivate…

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CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination

Abstract Background A barrier to HIV-1 cure rests in the persistence of proviral DNA in infected CD4+ leukocytes. The high HIV-1 mutation rate leads to viral diversity, immune evasion, and consequent antiretroviral drug resistance. While CRISPR-spCas9 can eliminate latent proviral DNA, its efficacy is limited by HIV strain diversity and…

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Physiologically based pharmacokinetic (PBPK) modelling of tamsulosin to related CYP2D6*10 allele

Ashley C, Dunleavy A, Cunningham J (2018) The renal drug handbook: the ultimate prescribing guide for renal practitioners, 5th edn. CRC Press, Boca Raton, p 960. doi.org/10.1201/9780429460418 Book  Google Scholar  Bae JW, Oh KY, Yoon SJ, Shin HB, Jung EH, Cho CK, Lim CW, Kang P, Choi CI, Jang CG,…

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Kline Discusses Challenges of CAR T-Cell Therapy in R/R DLBCL

Looking at the challenges with CAR T-cell therapies in patients with diffuse large B-cell lymphoma Justin Kline, MD, discusses the best available therapies for patients who relapse on treatment. During a live virtual event with other physicians, Justin Kline, MD, discussed the role of CAR (chimeric antigen receptor) T-cell therapy…

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An empirical analysis of mtSSRs: could microsatellite distribution patterns explain the evolution of mitogenomes in plants?

Levinson G, Gutman GA (1987) Slipped-strand mispairing: a major mechanism for DNA sequence evolution. Mol Biol Evol 4:203–221 CAS  PubMed  Google Scholar  Schlotterer C, Tautz D (1992) Slippage synthesis of simple sequence DNA. Nucleic Acids Res 20:211–215 CAS  PubMed  PubMed Central  Google Scholar  Tautz D, Schlotterer C (1994) Simple sequences….

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Different gene rearrangements of the genus Dardanus (Anomura: Diogenidae) and insights into the phylogeny of Paguroidea

1. Boore, J. L. Animal mitochondrial genomes. Nucl. Acids Res. 27, 1767–1780 (1999). CAS  PubMed  PubMed Central  Article  Google Scholar  2. Gyllensten, U., Wharton, D., Josefsson, A. & Wilson, A. C. Paternal inheritance of mitochondrial DNA in mice. Nature 352, 255–257 (1991). ADS  CAS  PubMed  Article  PubMed Central  Google Scholar …

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The pathology, phylogeny, and epidemiology of Echinococcus ortleppi (G5 genotype): a new case report of echinococcosis in China | Infectious Diseases of Poverty

1. Wang X, Liu J, Zuo Q, Mu Z, Weng X, Sun X, et al. Echinococcus multilocularis and Echinococcus shiquicus in a small mammal community on the eastern Tibetan Plateau: host species composition, molecular prevalence, and epidemiological implications. Parasit Vectors. 2018;11(1):302. doi.org/10.1186/s13071-018-2873-x. CAS  Article  PubMed  PubMed Central  Google Scholar  2….

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Comment: DSSP: P secondary structure

This is one of the files, 1maa.dssp: “` ==== Secondary Structure Definition by the program DSSP, NKI version 3.0 ==== DATE=2021-09-20 . REFERENCE W. KABSCH AND C.SANDER, BIOPOLYMERS 22 (1983) 2577-2637 . HEADER HYDROLASE 04-NOV-98 1MAA . COMPND MOL_ID: 1; MOLECULE: ACETYLCHOLINESTERASE; CHAIN: A, B, C, D; FRAGMENT: CATALYTIC DOMAIN;…

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ARGs as potential biomarkers & therapeutic targets in AF

Introduction Atrial fibrillation (AF) is the most common clinically sustained cardiac rhythm disorder. There is a high prevalence of AF all over the world, the highest in North America, Europe, China, and Southeast Asia, with approximately 270–360 cases per 100,000 people.1 Due to the lack of understanding of the pathogenesis…

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Metagenome-assembled genomes: concepts, analogies, and challenges

Almeida A, Nayfach S, Boland M, Strozzi F, Beracochea M, Shi ZJ, Pollard KS, Sakharova E, Parks DH, Hugenholtz P, Segata N, Kyrpides NC, Finn RD (2021) A unified catalog of 204,938 reference genomes from the human gut microbiome. Nat Biotechnol 39(1):105–114. doi.org/10.1038/s41587-020-0603-3 CAS  Article  PubMed  Google Scholar  Bowers RM,…

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Candidate genes associated with synovial macrophages

Jia Xu,1 Ming-Ying Zhang,2 Wei Jiao,1 Cong-Qi Hu,1 Dan-Bin Wu,2 Jia-Hui Yu,1 Guang-Xing Chen2,3 1First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, People’s Republic of China; 2Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, Guangdong, People’s Republic of China;…

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Scientists develop AI modeling to better understand about protein-sugar structures

The sugars attached to the reported software are a very good match to both AlphaFold and experimental protein models. Credits: Dr. Jon Agirre New research building on AI algorithms has allowed scientists to create more complete models of protein structures in our bodies — paving the way for faster design…

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Scientists rely on artificial intelligence modeling to understand more about protein-sugar structures

The sugars linked with the reported software are a very good match with both AlphaFold and experimental protein models. Credit: Dr Jon Agirre New research based on artificial intelligence algorithms has enabled scientists to create more complete models of the protein structures in our bodies, paving the way for faster…

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Venatorbacter cucullus gen. nov sp. nov a novel bacterial predator

1. Pérez, J., Moraleda-Muñoz, A., Marcos-Torres, F. J. & Muñoz-Dorado, J. Bacterial predation: 75 years and counting!. Environ. Microbiol. 18, 766–779 (2016). PubMed  Article  PubMed Central  Google Scholar  2. Linares-Otoya, L. et al. Diversity and antimicrobial potential of predatory bacteria from the Peruvian coastline. Mar. Drugs. 15, E308. doi.org/10.3390/md15100308 (2017)….

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Improving ligand-ranking of AutoDock Vina by changing the empirical parameters

doi: 10.1002/jcc.26779. Online ahead of print. T Ngoc Han Pham  1 , Trung Hai Nguyen  2   3 , Nguyen Minh Tam  3   4 , Thien Y Vu  1 , Nhat Truong Pham  5 , Nguyen Truong Huy  1 , Binh Khanh Mai  6 , Nguyen Thanh Tung  7   8 , Minh Quan Pham  8  …

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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

1. Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N. & Gallant, P. Drosophila myc regulates cellular growth during development. Cell 98, 779–790 (1999). CAS  PubMed  Article  Google Scholar  2. Sabo, A. et al. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature 511,…

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LAMMPS Patch Release 27 October 2021

LAMMPS Patch Release Overview What is LAMMPS used for? LAMMPS is a classical molecular dynamics (MD) code that models ensembles of particles in a liquid, solid, or gaseous state. It can model atomic, polymeric, biological, solid-state (metals, ceramics, oxides), granular, coarse-grained, or macroscopic systems using a variety of interatomic potentials…

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The genomic origins of the Bronze Age Tarim Basin mummies

1. Peyrot, M. in Aspects of Globalisation: Mobility, Exchange and the Development of Multi-Cultural States 12–17 (2017). 2. Damgaard, P. et al. 137 ancient human genomes from across the Eurasian steppes. Nature 557, 369–374 (2018). CAS  PubMed  Article  ADS  PubMed Central  Google Scholar  3. Hemphill, B. E. & Mallory, J….

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European bioinformatics institute

EMBL Heidelberg. Meyerhofstraße 1 69117 Heidelberg, Germany Tel: +49 6221 387-0 Fax: +49 6221 387-8306 Full contact details › 2021-04-01 European Bioinformatics Institute; NHS Department of Gastroenterology; Gurdon Institute; Department of Haematology; Hutchison/MRC Research Centre; Wellcome Trust-MRC Institute of Metabolic Science; MRC Laboratory of Molecular Biology; Molecular Immunity Unit- Department…

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Worker-dependent gut symbiosis in an ant

1. Lundberg JO, Weitzberg E, Cole JA, Benjamin N. Nitrate, bacteria and human health. Nat Rev Microbiol. 2004;2:593–602. CAS  PubMed  Article  PubMed Central  Google Scholar  2. Bulgarelli D, Schlaeppi K, Spaepen S, Van Themaat EVL, Schulze-Lefert P. Structure and functions of the bacterial microbiota of plants. Annu Rev Plant Biol….

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KEGG COMPOUND: C00222

Entry C00222                      Compound                                Name 3-Oxopropanoate;Malonate semialdehyde Formula C3H4O3 Exact mass 88.016 Mol weight 88.0621 Structure Mol fileKCF fileDB search Reaction Pathway map00562   Inositol phosphate metabolism map00625   Chloroalkane and chloroalkene degradation map00720   Carbon fixation pathways in prokaryotes map01120   Microbial metabolism in diverse environments Module M00013   Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA M00375  …

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Data Analysis, Integration and Visualization on 5000+ Pathways/3000+ Species

Tool:SBGNview: Data Analysis, Integration and Visualization on 5000+ Pathways/3000+ Species 1 Dear all, The new SBGNview package has been released with major updates and improvement: GitHub github.com/datapplab/SBGNview BioC bioconductor.org/packages/SBGNview/ SBGNview is a tool set for pathway based data visualization, integration and analysis. SBGNview is similar and complementary to the widely…

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A Pipeline for Analyzing eCLIP and iCLIP Data with Htseq-clip and DEWSeq

doi: 10.1007/978-1-0716-1851-6_10. Affiliations Expand Affiliations 1 European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. 2 European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. schwarzl@embl.de. Item in Clipboard Sudeep Sahadevan et al. Methods Mol Biol. 2022. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1007/978-1-0716-1851-6_10. Affiliations 1 European Molecular Biology Laboratory (EMBL), Heidelberg,…

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Molecular docking considerations

I am performing molecular docking experiments but find that the results are “pre-determined” by the setting used. Therefore, I am looking for a general guideline on performing docking and subsequent interpretation. (I know docking is all hypothetical and needs further experimental validation, but in this question please assume, although might…

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PER1 as a Tumor Suppressor Attenuates Breast Cancer

Introduction Breast cancer is one of the most common malignancies in women, with a high mortality rate around the world.1,2 Although multidisciplinary therapeutic strategies, including surgical resection, chemoradiotherapy, endocrine and anti-HER2 therapy, have made substantial progress over the past decade, there are still a considerable proportion of breast cancer patients…

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AI revolutions in biology: The joys and perils of AlphaFold

doi: 10.15252/embr.202154046. Online ahead of print. Affiliations Expand Affiliation 1 Oncode Institute and Division of Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Item in Clipboard Anastassis Perrakis et al. EMBO Rep. 2021. Show details Display options Display options Format AbstractPubMedPMID doi: 10.15252/embr.202154046. Online ahead of print. Affiliation 1 Oncode Institute…

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Bioinformatics Prediction and Analysis of MicroRNAs and Their Targets as Biomarkers for Prostate Cancer: A Preliminary Study

This article was originally published here Mol Biotechnol. 2021 Oct 19. doi: 10.1007/s12033-021-00414-8. Online ahead of print. ABSTRACT Prostate cancer (PCa) is the second most common form of cancer in men around the world. Due to its heterogeneity, presentations range from aggressive lethal disease to indolent disease. There is a…

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Severe trauma and burns accompanied by sepsis

Introduction Trauma accounts for approximately 10% of deaths and 16% of disabilities worldwide.1 Billions of dollars have been spent on research into new biological therapeutics for severe injuries, as well as post-traumatic sepsis and septic shock.2 Burn injuries cause unpredictable trauma and sepsis is a complication associated with high morbidity…

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Atherosclerosis Pathways are Activated in Pericoronary Adipose Tissue

Introduction Obesity, particularly abdominal obesity, is one of the most important risk factors for atherosclerosis and cardiovascular events.1–3 The volume and thickness of epicardial adipose tissue (EAT) correlate with intra-abdominal fat mass and the severity of obesity4,5 and are independently associated with cardiovascular events.6 Many studies have shown that inflammation…

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Clinical Impact of X-Ray Repair Cross-Complementary 1 (XRCC1) and the

Plain Language Summary Colorectal cancer progresses through a well‑defined series of transformations from normal colonic epithelial cells to precursor adenoma lesions that eventually evolve into increasingly more invasive and malignant stages. An improved understanding of the genetic and molecular drivers of colorectal cancer, especially the progression of adenoma to carcinoma,…

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H/ACA snoRNP gene family as diagnostic/prognostic biomarkers

Introduction Primary liver cancer, including hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma, is the sixth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths worldwide.1 High metastasis and recurrence rates, as well as limited treatment options, lead to the poor prognosis of advanced HCC.2 Among patients diagnosed with…

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