Tag: MRC

13 December 2021 Gene expression during early development of primordial germ cells (PGCs) is sex-specific. Research led by Professor Petra Hajkova from the Reprogramming and Chromatin research group at the Medical Research Council London Institute of Medical Sciences has shown for the first time that germ cells, which give rise…

Scientists have obtained stem cells from pigs, sheep, and cattle without the need for serum, feeder cells, or antibiotics to pave the way for “manufacturing cell-cultured meat and breeding enhanced livestock”. The researchers for the study were mainly from the University of Nottingham’s School of Biosciences in the UK, in…

Location: The Francis Crick Institute, Midland Road, London Contract: Fixed Term (3 years), Full time Short summary Dr Samra Turajlic is a Clinician Scientist with clinical practice in renal cell cancer and melanoma and the programme reflects emerging clinical questions tackled through a combination of cutting-edge methods. The overall aim of the…

Scientists have for the first time obtained stem cells from livestock that grow under chemically defined conditions, paving the way for manufacturing cell cultured meat and breeding enhanced livestock. Researchers from the University of Nottingham’s School of Biosciences, together with colleagues at the Universities of Cambridge, Exeter Tokyo and Meiji…

Computational design Protein modeling and design was performed with Rosetta version 3.5 (2015.19.57819)35,37. Python and shell scripts for generating input from Rosetta and analyzing from Rosetta are available at: github.com/raman-lab/biosensor_design The high-resolution TtgR structure co-crystalized with tetracycline was selected as the starting point for computational design (PDB: 2UXH)28. The structure…

cellranger count DETECT_COUNT_CHEMISTRY (failed) 0 I am learning scRNA-seq and the tutorial I follow uses dataset (1k pbmcs from healthy donor) from 10X genomics website. I downloaded fastq and reference transcriptome files and ran following command. cellranger-6.1.1/cellranger count –id pbmc_1k_v2_example –transcriptome /home/murat/Share/single_cell/refdata-gex-GRCh38-2020-A –fastqs /home/murat/Share/single_cell/pbmc_1k_v2_fastqs I get following message. Martian Runtime…

Short summary The position of Bioinformatics Training Developer will provide support to the bioinformatics training and development needs of research scientists primarily RNA-Seq, ATAC-Seq, ChiP-Seq and single-cell RNA-Seq. There are 2000 research scientists at the Francis Crick Institute. The role-holder will be located within the Bioinformatics and Biostatistics Core in…

Short summary The position of Bioinformatics Officer within the Bioinformatics Core Facility will provide primarily computational and bioinformatics expertise to support high throughput post-genomic technologies (next generation sequencers), within an informed biological context, not only for research scientists within the Francis Crick Institute but also for other members of the…

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Common medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially reducing the medications’ effectiveness. “If we can characterise how people respond depending on the composition of their microbiome, then drug treatments could be individualised,”Kiran Patil These interactions – seen for many drugs including…

Drug accumulation may reduce drug effectiveness and alter the gut microbiome Commonly used drugs accumulate in human gut bacteria, which can affect the drugs’ effectiveness and change the bacteria’s metabolism. Credit: Aleksandra Krolik Common medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially…

Abstract A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of…