Tag: MRC

Pregap4 – Table of Contents

Organisation of the Pregap4 Manual Introduction Summary of the Files used and the Processing Steps Introduction to the Pregap4 User Interface Introduction to the Files to Process Window Introduction to the Configure Modules Window Introduction to the Textual Output Window Introduction to Running Pregap4 Pregap4 Menus Pregap4 File menu Pregap4…

Continue Reading Pregap4 – Table of Contents

The Staden Package Mini-Manual – Viewing Traces Using Trev

The Staden Package Mini-Manual – Viewing Traces Using Trev For some types of sequencing project it is convenient to view and edit the chromatogram data prior to assembly into a gap4 database, and this is the function of the program trev. Trev displays the original trace data, its base calls…

Continue Reading The Staden Package Mini-Manual – Viewing Traces Using Trev

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

doi: 10.1038/s41556-022-00989-7. Online ahead of print. Brandon T Wesley #  1   2 , Alexander D B Ross #  1   2   3 , Daniele Muraro  1   2   4 , Zhichao Miao  4   5 , Sarah Saxton  6   7 , Rute A Tomaz  1   2 , Carola M Morell  1   2…

Continue Reading Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

Bioinformatician / Senior Scientist / Bioinformatics

Constructive Bio is a VC-backed biotechnology startup based at Chesterford Research Park. Our breakthrough technology harnesses the power of genome rewriting and genetic code reprogramming to make valuable products that positively impact the world. We will use our platform to turn cells into bio-renewable factories for the production of novel…

Continue Reading Bioinformatician / Senior Scientist / Bioinformatics

Impact of DNA mutations on lifelong blood cell production uncovered — ScienceDaily

New research has uncovered how genetic mutations hijack the production of blood cells in different periods of life. Scientists at the Wellcome Sanger Institute, the Cambridge Stem Cell Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI) and collaborators show how these changes relate to ageing and the development of age-related diseases, including…

Continue Reading Impact of DNA mutations on lifelong blood cell production uncovered — ScienceDaily

TREEFROG THERAPEUTICS LAUNCHES A $100,000 RESEARCH GRANT IN REGENERATIVE MEDICINE

Bordeaux, France / April 19th, 2022 – TreeFrog Therapeutics, a biotechnology company aimed at making safer, more efficient and more affordable cell therapies based on induced pluripotent stem cells (iPSCs), today announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell…

Continue Reading TREEFROG THERAPEUTICS LAUNCHES A $100,000 RESEARCH GRANT IN REGENERATIVE MEDICINE

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands Aysu Okbay, Hyeokmoon Kweon & Philipp D. Koellinger Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia Yeda Wu, Julia Sidorenko, Jian Yang, Loic Yengo & Peter M. Visscher National Bureau of Economic Research, Cambridge, MA, USA Nancy Wang, Hariharan Jayashankar, Michael Bennett, Grant Goldman, Tamara Gjorgjieva, Steven…

Continue Reading Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals

Mechanisms involved in the transmission of genetic diseases from mother to child

Mitochondria are the organelles that produce most of the chemical energy needed by the cell. Mitochondrial DNA (mtDNA) contains 16,569 nucleotides that can be mutated. Some of these mutations can lead to the development of mitochondrial diseases. While nuclear DNA (the well-known double helix, which encodes most of the genome)…

Continue Reading Mechanisms involved in the transmission of genetic diseases from mother to child

Research reveals mechanism involved in transm

image: Immature mouse egg at a stage prior to ovulation, with mitochondria stained red view more  Credit: Marcos Roberto Chiaratti A research article published in the journal Science Advances describes a mechanism that helps explain how certain kinds of genetic disorders known as mitochondrial diseases are transmitted from mother to child. The study it reports…

Continue Reading Research reveals mechanism involved in transm

Bioconductor – r3Cseq

    This package is for version 3.3 of Bioconductor; for the stable, up-to-date release version, see r3Cseq. Analysis of Chromosome Conformation Capture and Next-generation Sequencing (3C-seq) Bioconductor version: 3.3 This package is an implementation of data analysis for the long-range interactions from 3C-seq assay. Author: Supat Thongjuea, MRC Molecular…

Continue Reading Bioconductor – r3Cseq

Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection

INTRODUCTION Dengue is the most common mosquito-borne viral disease globally (1). This acute disease, which can be life-threatening, is caused by four different dengue viruses (DENVs) (DENV-1, DENV-2, DENV-3, and DENV-4). An estimated 390 million people are infected with these DENVs annually (2), and populations throughout the tropics face frequent…

Continue Reading Cell Strain-Derived Induced Pluripotent Stem Cells as an Isogenic Approach To Investigate Age-Related Host Response to Flaviviral Infection

Seven technologies to watch in 2022

The Telomere-to-Telomere Consortium is sequencing whole chromosomes.Credit: Adrian T. Sumner/SPL From gene editing to protein-structure determination to quantum computing, here are seven technologies that are likely to have an impact on science in the year ahead. Fully finished genomes Roughly one-tenth of the human genome remained uncharted when genomics researchers…

Continue Reading Seven technologies to watch in 2022

Early male and female germ cells regulate their gene expression differently

13 December 2021 Gene expression during early development of primordial germ cells (PGCs) is sex-specific. Research led by Professor Petra Hajkova from the Reprogramming and Chromatin research group at the Medical Research Council London Institute of Medical Sciences has shown for the first time that germ cells, which give rise…

Continue Reading Early male and female germ cells regulate their gene expression differently

Stem cell study paves way for gene editing to produce cultured meat

  Scientists have obtained stem cells from pigs, sheep, and cattle without the need for serum, feeder cells, or antibiotics to pave the way for “manufacturing cell-cultured meat and breeding enhanced livestock”. The researchers for the study were mainly from the University of Nottingham’s School of Biosciences in the UK,…

Continue Reading Stem cell study paves way for gene editing to produce cultured meat

Postdoctoral Research Scientist, Bioinformatics – Turajlic Lab at The Francis Crick Institute

Location: The Francis Crick Institute, Midland Road, London Contract: Fixed Term (3 years), Full time Short summary Dr Samra Turajlic is a Clinician Scientist with clinical practice in renal cell cancer and melanoma and the programme reflects emerging clinical questions tackled through a combination of cutting-edge methods. The overall aim of the…

Continue Reading Postdoctoral Research Scientist, Bioinformatics – Turajlic Lab at The Francis Crick Institute

Stem cell study paves way for manufacturing cultured meat — ScienceDaily

Scientists have for the first time obtained stem cells from livestock that grow under chemically defined conditions, paving the way for manufacturing cell cultured meat and breeding enhanced livestock. Researchers from the University of Nottingham’s School of Biosciences, together with colleagues at the Universities of Cambridge, Exeter Tokyo and Meiji…

Continue Reading Stem cell study paves way for manufacturing cultured meat — ScienceDaily

Epistasis shapes the fitness landscape of an allosteric specificity switch

Computational design Protein modeling and design was performed with Rosetta version 3.5 (2015.19.57819)35,37. Python and shell scripts for generating input from Rosetta and analyzing from Rosetta are available at: github.com/raman-lab/biosensor_design The high-resolution TtgR structure co-crystalized with tetracycline was selected as the starting point for computational design (PDB: 2UXH)28. The structure…

Continue Reading Epistasis shapes the fitness landscape of an allosteric specificity switch

cellranger count DETECT_COUNT_CHEMISTRY (failed)

cellranger count DETECT_COUNT_CHEMISTRY (failed) 0 I am learning scRNA-seq and the tutorial I follow uses dataset (1k pbmcs from healthy donor) from 10X genomics website. I downloaded fastq and reference transcriptome files and ran following command. cellranger-6.1.1/cellranger count –id pbmc_1k_v2_example –transcriptome /home/murat/Share/single_cell/refdata-gex-GRCh38-2020-A –fastqs /home/murat/Share/single_cell/pbmc_1k_v2_fastqs I get following message. Martian Runtime…

Continue Reading cellranger count DETECT_COUNT_CHEMISTRY (failed)

Bioinformatics Training Developer at The Francis Crick Institute

Short summary The position of Bioinformatics Training Developer will provide support to the bioinformatics training and development needs of research scientists primarily RNA-Seq, ATAC-Seq, ChiP-Seq and single-cell RNA-Seq. There are 2000 research scientists at the Francis Crick Institute. The role-holder will be located within the Bioinformatics and Biostatistics Core in…

Continue Reading Bioinformatics Training Developer at The Francis Crick Institute

Bioinformatics Core Facility at The Francis Crick Institute

Short summary The position of Bioinformatics Officer within the Bioinformatics Core Facility will provide primarily computational and bioinformatics expertise to support high throughput post-genomic technologies (next generation sequencers), within an informed biological context, not only for research scientists within the Francis Crick Institute but also for other members of the…

Continue Reading Bioinformatics Core Facility at The Francis Crick Institute

SCIRP Open Access

Add your e-mail address to receive free newsletters from SCIRP. Select Journal AA AAD AAR AASoci AAST ABB ABC ABCR ACES ACS ACT AD ADR AE AER AHS AID AiM AIT AJAC AJC AJCC AJCM AJIBM AJMB AJOR AJPS ALAMT ALC ALS AM AMI AMPC ANP APD APE APM ARS ARSci AS ASM BLR CC CE CellBio ChnStd CM CMB CN CRCM CS CSTA CUS CWEEE Detection EMAE ENG EPE ETSN FMAR FNS GEP GIS GM Graphene GSC Health IB ICA IIM IJAA IJAMSC IJCCE IJCM IJCNS IJG IJIDS IJIS IJMNTA IJMPCERO IJNM IJOC IJOHNS InfraMatics JACEN JAMP JASMI JBBS JBCPR JBiSE JBM JBNB JBPC JCC JCDSA JCPT JCT JDAIP JDM JEAS JECTC JEMAA JEP JFCMV JFRM JGIS JHEPGC JHRSS JIBTVA JILSA JIS JMF JMGBND JMMCE JMP JPEE JQIS JSBS JSEA JSEMAT JSIP JSS JSSM JST JTR JTST JTTs JWARP LCE MC ME MI MME MNSMS MPS MR MRC MRI MSA MSCE NJGC NM NR NS OALib OALibJ ODEM OJA OJAB OJAcct OJAnes OJAP OJApo OJAppS OJAPr OJAS OJBD OJBIPHY OJBM OJC OJCB OJCD OJCE OJCM OJD OJDer OJDM OJE OJEE OJEM OJEMD OJEpi OJER OJF OJFD OJG OJGas OJGen OJI OJIC OJIM OJINM OJL OJM OJMC OJMetal OJMH OJMI OJMIP OJML OJMM OJMN OJMP OJMS OJMSi OJN OJNeph OJO OJOG OJOGas OJOp OJOph OJOPM OJOTS OJPathology OJPC OJPChem OJPed OJPM OJPP OJPS OJPsych OJRA OJRad OJRD OJRM OJS OJSS OJSST OJST OJSTA OJTR OJTS OJU OJVM OPJ POS PP PST PSYCH SAR SCD SGRE SM SN SNL Soft SS TEL TI UOAJ VP WET WJA WJCD WJCMP WJCS WJET WJM WJNS WJNSE WJNST WJV WSN YM Read more here: Source link

Continue Reading SCIRP Open Access

Some Medications Can Accumulate in Gut Bacteria

Common medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially reducing the medications’ effectiveness. “If we can characterise how people respond depending on the composition of their microbiome, then drug treatments could be individualised,”Kiran Patil These interactions – seen for many drugs including…

Continue Reading Some Medications Can Accumulate in Gut Bacteria

Common medications accumulate in gut bacteria

Drug accumulation may reduce drug effectiveness and alter the gut microbiome Commonly used drugs accumulate in human gut bacteria, which can affect the drugs’ effectiveness and change the bacteria’s metabolism. Credit: Aleksandra Krolik Common medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially…

Continue Reading Common medications accumulate in gut bacteria

Multiform antimicrobial resistance from a metabolic mutation

Abstract A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of…

Continue Reading Multiform antimicrobial resistance from a metabolic mutation