Tag: MRC

Dotplot : how to self-define the range of legend 0 Hi everyone, The default range of the Percent Expressed legend ranges from “20” “40” “60” (as shown in the figure), how can I change it to “0 25 50 75 100”? DotPlot(mrc.har_sub, features = markers.to.plot , dot.scale = 10) +…

Wallace DC. Mitochondrial genetic medicine. Nat Genet. 2018;50:1642–9. Article  CAS  PubMed  Google Scholar  Nunnari J, Suomalainen A. Mitochondria: in sickness and in health. Cell. 2012;148(6):1145–59. Article  CAS  PubMed  PubMed Central  Google Scholar  Chan DC. Mitochondria: dynamic organelles in disease, aging, and development. Cell. 2006;125(7):1241–52. Article  CAS  PubMed  Google Scholar  Picard…

www.nature.com/articles/d41586-023-02943-5 Google DeepMind has wielded its revolutionary protein-structure-prediction AI in the hunt for genetic mutations that cause disease. A new tool based on the AlphaFold network can accurately predict which mutations in proteins are likely to cause health conditions — a challenge that limits the use of genomics in healthcare….

DarioSB September 20, 2023, 10:45am #1 Dear all,is it possible to use an AlphaFold predicted structure as templates for picking?BestDario Hi Dario, You could use the molmap feature in ChimeraX to generate a volume of the alphafold structure (e.g. to 6 angstrom), save as an mrc file, import to cryosparc…

A patient receives treatment for cystic fibrosis, a disease linked in some cases to missense mutations.Credit: Burger/Phanie/Science Photo Library Google DeepMind has wielded its revolutionary protein-structure-prediction AI in the hunt for genetic mutations that cause disease. A new tool based on the AlphaFold network can accurately predict which mutations in…

Ian Wilmut, the embryologist most known for cloning Dolly the sheep, passed away at age 79 from complications of Parkinson’s Disease, according to news from the University of Edinburgh. Wilmut’s work represented a milestone in the field of regenerative medicine and stem cell research. Born to teachers in a Warwickshire…

News Update Awakn Life Sciences has applied for Phase 3 of clinical trials after the success of Phase 2. Read on to see what this company plans for its flagship new drug. The Canadian-based biotechnology company Awakn Life Sciences Corp. (NEO:AWKN; OTCQB:AWKNF; FSE:954) has applied for a Clinical Trial Application (CTA)…

Subjects TP53 gene was investigated in 880 consecutive oncology patients referred for molecular genetic testing at our national centres (Department of Laboratory Medicine, Semmelweis University and Department of Molecular Genetics, National Institute of Oncology) between 2021 and 2022. This cohort consisted of patients with potential hereditary tumour predisposition. Their genetic…

The test involves patients giving a blood sample, which is used to extract DNA for limited sequencing. Credit Nguyễn Hiệp on Unsplash. Researchers from the Wellcome-MRC Cambridge Stem Cell Institute (CSCI), the University of Cambridge’s Department of Haematology and the Instituto de Investigación Sanitaria del Principado de Asturias (ISPA) have…

Description Jobs in Structural Biology and Related Fields MRC Laboratory of Molecular Biology, Cambridge, United Kingdom A postdoctoral researcher to investigate the molecular mechanisms of bacterial cell division through in situ structural biology has become available. The goal of the project is to reveal the organisation and structure of the…

image: The developing human yolk sac floats like a balloon in the exocoelomic cavity view more  Credit: Megumi Inoue, DOI: 10.1126/science.add7564 The role of the human yolk sac in supporting early embryonic development and the first wave of the prenatal immune system has been mapped in a study published today (17…

The University of Cambridge wishes to appoint a talented research associate in bioinformatics and computational biology to join a team of clinical, laboratory and computational scientists in the research groups of Prof Patrick Chinnery and Dr Jelle van den Ameele at the Department of Clinical Neurosciences and the MRC Mitochondrial…

A team of UK-based scientists has developed a new database of genes largely unknown to science, despite being part of our DNA. These genes encode proteins, but their functions remain a mystery. The database, called Unknome, is a public and customizable resource that can help researchers identify and investigate these…

Around 20,000 genes that code for proteins have been identified in humans, but the function of many of these proteins is unknown SCIENCE PHOTO LIBRARY A database of proteins, dubbed the “unknome”, that ranks proteins according to how much we have learned about them has revealed that we still know…

NEW YORK – Using a systematic screening strategy, a UK team has started characterizing proteins from its “unknome” database that are conserved across species but have yet-to-be-determined functions. “It has become clear that scientific research tends to focus on well-studied proteins, leading to a concern that poorly understood genes are…

Mitchell, K. S. et al. Binge eating disorder: a symptom-level investigation of genetic and environmental influences on liability. Psychol. Med. 40, 1899–1906 (2010). Article  CAS  PubMed  PubMed Central  Google Scholar  Reichborn-Kjennerud, T., Bulik, C. M., Tambs, K. & Harris, J. R. Genetic and environmental influences on binge eating in the…

Interactions between genes and environmental factors like diet determine people’s weight and body size. Now, new research that looked at data from over 400,000 adults suggests that the effects of some genes on obesity risk depend on the biological sex and age of the individual. Full details of the findings…

On this new Psychedelics Exclusive podcast, TDR Founder Shadd Dales interviews Awakn Life Sciences Corp. AWKNF CEO Anthony Tennyson, as his company moves closer towards a Phase III clinical trial exploring the use of ketamine-assisted therapy to treat severe Alcohol Use Disorder (AUD). Mr. Tennyson also provides color on the recent divestiture of…

On this new Psychedelics Exclusive podcast, TDR Founder Shadd Dales interviews Awakn Life Sciences Corp. (NEO: AWKN) (OTCMKTS: AWKNF) CEO Anthony Tennyson, as his company moves closer towards a Phase III clinical trial exploring the use of ketamine-assisted therapy to treat severe Alcohol Use Disorder (AUD). Mr. Tennyson also provides color on the…

The post We are looking to recruit a bioinformatician to work on a project funded by the Medical Research Council that aims to explore epigenetic variation associated with Alzheimer’s disease. Specifically, the successful candidate will undertake bioinformatic analyses, working with epigenomic data (DNA methylation, chromatin accessibility, histone modifications) generated by our…

Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, et al. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood. 2016;127:2391–405. Article  CAS  PubMed  Google Scholar  Grimwade D, Walker H, Harrison G, Oliver F, Chatters S, Harrison CJ, et…

New research from the University of Exeter reports the largest ever whole-genome sequencing project for the potentially fatal yeast infection Candida glabrata from hospitals across Scotland. Microscropic c.glabrata New research from the University of Exeter reports the largest ever whole-genome sequencing project for the potentially fatal yeast infection Candida glabrata…

The Healthcare Technology Report is pleased to announce The Top 25 Healthcare Technology Leaders of Connecticut for 2023. There is no shortage of reasons for why Connecticut has a flourishing healthcare sector these days. The Nutmeg State, while small, boasts a high concentration of top-ranked hospitals and medical centers, renowned…

In its 28th edition, Eppendorf SE, the Hamburg-based life sciences company, is once again awarding its esteemed research prize. The independent jury, led by Professor Reinhard Jahn, has chosen Dr Maurice Michel from the Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden, as the distinguished recipient of the €20,000 Eppendorf…

Gene expression and RNA splicing explain large proportions of the heritability for complex traits in cattle” (www.biorxiv.org/content/10.1101/2022.05.30.494093v1) Summary stats of cis and trans eQTL and sQTL mapped from 16 cattle tissues (N~5000) using linear mixed model. Multi-tissue eQTL and sQTL (from meta-analysis) are also included. For details, please read “esQTLSumdataXiang2022/README.txt”…

This new work focused on a particular subset of E. coli with a specific capsule – the extracellular barrier that surrounds a bacterium – which scientists have called K1. E. coli with this type of capsule are known to cause invasive diseases such as bloodstream or kidney infections, and meningitis…

Microbial Sciences Location: Guildford Salary: £35,308 to £37,386 per annum Fixed Term Post Type: Full Time Closing Date: 23.59 hours BST on Monday 10 July 2023 Reference: 030623 Duration: 12 months with the possibility of further extension Start date: Available immediately (Interviews are likely to be held W/C 17 July 2023) RNA…

Location: The Francis Crick Institute, Midland Road, London Short summary Crick employs about 20 expert staff in its Bioinformation & Biostatics core facility who provide a wide range of professional support to Crick scientists to get the best value from their datasets. This core facility enables research groups to access the…

MRC Epidemiology Unit Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK Alice Williamson, Jian’an Luan, Nicholas J. Wareham, Eleanor Wheeler & Claudia Langenberg Metabolic Research Laboratories Wellcome Trust-MRC Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK Alice Williamson, Dougall M. Norris, Stephen O’Rahilly & Daniel J. Fazakerley Department of…

Global “Mice Model Market” is an exploration report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. These bits of knowledge offered in the Mice Model Market report would…

[1] Greene NDE, Copp AJ. Neural tube defects. Annu Rev Neurosci, 2014; 37, 221−42. [2] Marean A, Graf A, Zhang Y, et al. Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival. Hum Mol Genet, 2011; 20, 3678−83. …

Location: The Francis Crick Institute, Midland Road, London Short summary The Francis Crick Institute seeks to recruit a collaborative and self-motivated Senior Bioinformatician with extensive experience analysing biological data in a research environment. In this flexible role, you will collaborate with Francis Crick scientists to analyse data from the latest genomic…

. 2023 May 17;10:1086001. doi: 10.3389/fvets.2023.1086001. eCollection 2023. Gianluigi Rossi  1   2 , Barbara Bo-Ju Shih  1 , Nkongho Franklyn Egbe  3 , Paolo Motta  4 , Florian Duchatel  1 , Robert Francis Kelly  5 , Lucy Ndip  6   7 , Melissa Sander  8 , Vincent Ngwang Tanya  9 , Samantha J Lycett  1   2 , Barend…

by MERLIN CROSSLEY Say you wanted to improve how biomedical research is done. Perhaps you noticed that the world had changed and researchers could no longer answer the big questions with a Bunsen burner, a Petri dish, and a light microscope: they need a mass spectrometer, a cryogenic electron microscope,…

Advances in the last twenty years of genomics have turbocharged our ability to decode DNA and other nucleic acids. At the turn of the century, the Human Genome Project completed a 13-year journey to produce the first complete human genome at a great financial cost. In 2023, genome sequencing is a routine…

Overview of the isoform-specific determination of dUTPase gene expression Our aim was to determine the mRNA expression level of the dUTPase isoforms specifically. First, we investigated the Ensemble, the UniProt, and the NCBI Reference Sequences (RefSeq) databases and also took into account the Consensus CDS (CCDS) project. In the Ensemble…

Patients cohort Among consecutive patients who underwent BRCA tumour testing through ION Torrent-based sequencing between August 2017 and February 2022, we retrospectively selected 222 high-grade ovarian cancer (HGOC) patients with the following histological subtypes: 203 serous (HGSOC), seven endometrioid, five clear-cell and seven with mixed histotypes. Since NGS BRCA1/2 tumour…

Rare diseases affect less than 1 in 2,000 people, but with over 7,000 different diseases, together they present a major healthcare challenge affecting over 300 million people worldwide. Technological advances in gene therapy mean that, in the foreseeable future, many families with a genetic diagnosis will expect a treatment for…

Job description The Centre for Craniofacial & Regenerative Biology at King’s College London seeks to appoint a Lecturer in Computational Biology, Bioinformatics and/or Genomics. Applicants should be early career scientists with an outstanding research track record and an excellent potential to develop an internationally competitive research programme.   The Centre…

The role The Academic Clinical Lecturership in Haematology is a four-year post (at 1WTE) split 50:50 between clinical and academic training. Academic training in Platform Science and Bioinformatics will be within the Academic Haematology Group which undertakes gene discovery projects using national genomic data resources. Inferences derived from computational analyses…

The research partnership between UK-based psychedelics biotech Awakn Life Sciences Corp. AWKNF and the University of Exeter for an upcoming Phase 3 clinical trial has now formalized the study’s design, budget and the company’s contribution of about $1 million (GBP £800,000). The trial will assess ketamine-assisted therapy (KAT) for the treatment…

© Reuters. Severe Alcohol Use Disorder Patients Will Try Ketamine Therapy At Awakn’s New Phase 3 Study Benzinga – The research partnership between UK-based psychedelics biotech Awakn Life Sciences Corp. (OTCQB: AWKNF) and the University of Exeter for an upcoming Phase 3 clinical trial has now formalized the study’s design,…

On April 19, 2023, Awakn Life Sciences Corp. and the University of Exeter announced their collaboration agreement to conduct a Phase 3 clinical trial that will explore the use of ketamine-assisted therapy (KAT) for the treatment of severe Alcohol Use Disorder (AUD). The study will be conducted by Awakn’s head…

Phase 3 trials are the last major step in new drug approval and can cost a lot to operate. However, one Canadian pharma company’s product is so promising it has convinced the UK government to foot most of the bill. Awakn Life Sciences Corp. (AWKN:NEO; AWKNF:OTCQB) is a Canada-based biotechnology…

Design and synthesis of indolyl pyrimidinamine inhibitors of TTBK1/2 Our lead (AMG28, Fig. 1A) emerged from examination of the off-target activity of a published Amgen NF-κB inducing kinase (NIK) inhibitor27. The potency of AMG28 was reported in the MRC Kinase Profiling Inhibitor Database as 8% activity remaining for TTBK1 and 12%…

Human samples Placental and decidual samples used for the in vivo and in vitro profiling were obtained from elective terminations from: The MRC and Wellcome-funded Human Developmental Biology Resource (HDBR, www.hdbr.org), with appropriate maternal written consent and approval from the Fulham Research Ethics Committee (REC reference 18/LO/0822) and Newcastle and…

JAPAN — Scientists have created mice with two biologically male parents for the first time – a significant milestone in reproductive biology. The team, led by Katsuhiko Hayashi, a professor of genome biology at Osaka University in Japan, generated eggs from the skin cells of male mice that, when implanted…

Kerstin Meyer Kerstin Meyer is a principal staff scientist in cellular genetics, working with the Teichmann group and leading Human Cell Atlas projects within the Sanger Institute. Kerstin is using her expertise in molecular biology and transcriptional regulation of gene expression to lead extended pilot studies into data generation for…

What is Anomaly Detection? Anomaly detection, also known as outlier detection or novelty detection, is a method of identifying uncommon events, or data points that don’t conform to the expected pattern in a dataset. Anomaly detection is used in a wide range of applications, such as networking and security-related areas,…

By Benson S. Chen, MBChB, MSc, FRACP; Joshua P. Harvey, MA, BM BCh, Pg Cert, FRCOphth; and Patrick Yu-Wai-Man, PhD, BMedSci, MBBS, FRCPath, FRCOphth; Special to Ophthalmology Times® Inherited optic neuropathies (IONs) are a group of disorders that result in degeneration of the retinal ganglion cells (RGCs) and optic atrophy,1…

dave March 2, 2023, 7:50am 1 GROMACS version: gromacs-2022.2GROMACS modification: No Hi All,(maybe more relevant to Dr. Christian Blau) It has been long I did not do MD simulations. I came across an old Bioexcel webinar about density mediated simulation by Christian Blau. It seems to be a very helpful…

February 28 is Rare Disease Day; the day dedicated to raising awareness for the approximately 300 million people around the world living with a rare disease.  More than 6,000 rare diseases are characterized by a diversity of disorders and symptoms that vary not only from disease to disease, but also…

By University of Copenhagen – The Faculty of Health and Medical Sciences February 14, 2023 The new approach is called iDEMS (isolation of DNA by EdU labeling for Mass Spectrometry). A recent technical report in Nature Cell Biology has introduced a novel method to examine specific alterations in DNA following…

Location: The Francis Crick Institute, Midland Road, London Short summary An exciting opportunity to be part of a pioneering biomedical research institute, dedicated to innovation and science, in the laboratory of Samra Turajlic (Cancer Dynamics, www.crick.ac.uk/research/labs/samra-turajlic). We are seeking a highly collaborative and self-motivated student with experience in bioinformatics to work…

image: Sarah Teichmann receives the FEBS | EMBO Women in Science Award 2023 view more  Credit: EMBO/Jens Hedinger 9 February 2023 – EMBO and FEBS announce Sarah Teichmann of the Wellcome Sanger Institute and the Department of Physics of the University of Cambridge, UK, as the recipient of the FEBS |…

Julie Gould: 0:09 Hi, it’s Judy Gould and this is Working Scientist, a Nature Careers podcast. Welcome to this series on the podcast, All About Leadership. Each episode in this series explores leadership from a different perspective. We hear from academic leaders, research institute leaders, industry leaders, young leaders, as…

Feb 01, 2023 DOI: dx.doi.org/10.17504/protocols.io.bp2l69r8klqe/v1 Protocol Citation: Francesca Tonelli 2023. Immunofluorescence-based assay to assess LRRK2 recruitment by Rab29. protocols.io dx.doi.org/10.17504/protocols.io.bp2l69r8klqe/v1 License: This is an open access protocol distributed under the terms of the Creative Commons Attribution License,  which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited…

About the team/job Chronic kidney failure affects about 11% of the world population, of which one-third of cases involve immune-mediated disease. Those patients who reach end-stage kidney failure require renal replacement therapy, and though transplantation considerably improves the quality of life, the longevity of transplant organs is limited, mainly due…

Scott M, Dobson A. The role of parasites in regulating host abundance. Parasitol Today. 1989;5:176–83. CAS  Google Scholar  Tompkins D, Dobson A, Arneberg P, Begon M, Cattadori I, Greenman J, et al. Parasites and host population dynamics. The ecology of wildlife diseases. 2002; 45–62. Thomas F, Poulin R, Brodeur J….

European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK Claudia Calabrese, Nuno A. Fonseca, Lara Urban, Claudia Calabrese, Nuno A. Fonseca, Lara Urban, Liliana Greger, Nuno A. Fonseca, Lara Urban, Claudia Calabrese, Liliana Greger, Roland F. Schwarz, Oliver Stegle, Alvis Brazma, Alvis Brazma, Roland F. Schwarz & Oliver Stegle ETH Zurich, Zurich, Switzerland Natalie R. Davidson, André Kahles, Kjong-Van Lehmann, Natalie R. Davidson, André Kahles, Kjong-Van Lehmann, Stefan G. Stark, André Kahles, Kjong-Van Lehmann, Natalie R….

Applied Tumor Genomics Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland Lauri A. Aaltonen Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK Federico Abascal, David J. Adams, Ludmil B. Alexandrov, Sam Behjati, Shriram G. Bhosle, David T. Bowen, Adam P. Butler, Peter J. Campbell, Peter Clapham, Helen Davies, Kevin J. Dawson, Stefan C. Dentro, Serge Serge, Erik Garrison, Mohammed Ghori, Dominik Glodzik, Jonathan Hinton, David…

The Broad Institute of MIT and Harvard, Cambridge, MA, USA Esther Rheinbay, Jeremiah A. Wala, Ofer Shapira, Grace Tiao, Julian M. Hess, Ziao Lin, Jaegil Kim, Yosef E. Maruvka, Pratiti Bandopadhayay, John Busanovich, Nicholas J. Haradhvala, Kiran Kumar, Gordon Saksena, Steven E. Schumacher, Chip Stewart, Manolis Kellis, Michael S. Lawrence, Pratiti Bandopadhayay, Rameen Beroukhim, Gad Getz, Nicholas J. Haradhvala, Julian M. Hess, Manolis Kellis, Jaegil Kim, Michael S. Lawrence, Ziao Lin, Yosef E. Maruvka, Esther Rheinbay, Gordon Saksena, Steven…

image: David Baker, Frontiers of Knowledge Award winner in Biomedicine. view more  Credit: BBVA Foundation. The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this fifteenth edition to David Baker, Demis Hassabis and John Jumper “for their contributions to the use of artificial intelligence for the…

Applications are invited for a talented research associate in bioinformatics/computational biology to lead an exciting project aiming to shed light on the fundamental biology of neurodegenerative diseases and mitochondrial dysfunction using a single cell data set and functional genomic screens including CRISPR and Perturb-seq. The post holder will join Professor…

In this figure the Cutoff or Hidden data is being displayed for the right hand contig. One difference between the Contig Editor and the Join Editor is the Lock button. When set (as it is in the illustration) the two contigs scroll in register, otherwise they can be scrolled independently….

Organisation of the Pregap4 Manual Introduction Summary of the Files used and the Processing Steps Introduction to the Pregap4 User Interface Introduction to the Files to Process Window Introduction to the Configure Modules Window Introduction to the Textual Output Window Introduction to Running Pregap4 Pregap4 Menus Pregap4 File menu Pregap4…

The Staden Package Mini-Manual – Viewing Traces Using Trev For some types of sequencing project it is convenient to view and edit the chromatogram data prior to assembly into a gap4 database, and this is the function of the program trev. Trev displays the original trace data, its base calls…

doi: 10.1038/s41556-022-00989-7. Online ahead of print. Brandon T Wesley #  1   2 , Alexander D B Ross #  1   2   3 , Daniele Muraro  1   2   4 , Zhichao Miao  4   5 , Sarah Saxton  6   7 , Rute A Tomaz  1   2 , Carola M Morell  1   2…

Constructive Bio is a VC-backed biotechnology startup based at Chesterford Research Park. Our breakthrough technology harnesses the power of genome rewriting and genetic code reprogramming to make valuable products that positively impact the world. We will use our platform to turn cells into bio-renewable factories for the production of novel…

New research has uncovered how genetic mutations hijack the production of blood cells in different periods of life. Scientists at the Wellcome Sanger Institute, the Cambridge Stem Cell Institute, EMBL’s European Bioinformatics Institute (EMBL-EBI) and collaborators show how these changes relate to ageing and the development of age-related diseases, including…

Bordeaux, France / April 19th, 2022 – TreeFrog Therapeutics, a biotechnology company aimed at making safer, more efficient and more affordable cell therapies based on induced pluripotent stem cells (iPSCs), today announced the launch of The Stem Cell SpaceShot Grant, a $100,000 research funding in the field of stem cell…

Department of Economics, School of Business and Economics, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands Aysu Okbay, Hyeokmoon Kweon & Philipp D. Koellinger Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia Yeda Wu, Julia Sidorenko, Jian Yang, Loic Yengo & Peter M. Visscher National Bureau of Economic Research, Cambridge, MA, USA Nancy Wang, Hariharan Jayashankar, Michael Bennett, Grant Goldman, Tamara Gjorgjieva, Steven…

Mitochondria are the organelles that produce most of the chemical energy needed by the cell. Mitochondrial DNA (mtDNA) contains 16,569 nucleotides that can be mutated. Some of these mutations can lead to the development of mitochondrial diseases. While nuclear DNA (the well-known double helix, which encodes most of the genome)…

image: Immature mouse egg at a stage prior to ovulation, with mitochondria stained red view more  Credit: Marcos Roberto Chiaratti A research article published in the journal Science Advances describes a mechanism that helps explain how certain kinds of genetic disorders known as mitochondrial diseases are transmitted from mother to child. The study it reports…

    This package is for version 3.3 of Bioconductor; for the stable, up-to-date release version, see r3Cseq. Analysis of Chromosome Conformation Capture and Next-generation Sequencing (3C-seq) Bioconductor version: 3.3 This package is an implementation of data analysis for the long-range interactions from 3C-seq assay. Author: Supat Thongjuea, MRC Molecular…

INTRODUCTION Dengue is the most common mosquito-borne viral disease globally (1). This acute disease, which can be life-threatening, is caused by four different dengue viruses (DENVs) (DENV-1, DENV-2, DENV-3, and DENV-4). An estimated 390 million people are infected with these DENVs annually (2), and populations throughout the tropics face frequent…

The Telomere-to-Telomere Consortium is sequencing whole chromosomes.Credit: Adrian T. Sumner/SPL From gene editing to protein-structure determination to quantum computing, here are seven technologies that are likely to have an impact on science in the year ahead. Fully finished genomes Roughly one-tenth of the human genome remained uncharted when genomics researchers…

13 December 2021 Gene expression during early development of primordial germ cells (PGCs) is sex-specific. Research led by Professor Petra Hajkova from the Reprogramming and Chromatin research group at the Medical Research Council London Institute of Medical Sciences has shown for the first time that germ cells, which give rise…

  Scientists have obtained stem cells from pigs, sheep, and cattle without the need for serum, feeder cells, or antibiotics to pave the way for “manufacturing cell-cultured meat and breeding enhanced livestock”. The researchers for the study were mainly from the University of Nottingham’s School of Biosciences in the UK,…

Location: The Francis Crick Institute, Midland Road, London Contract: Fixed Term (3 years), Full time Short summary Dr Samra Turajlic is a Clinician Scientist with clinical practice in renal cell cancer and melanoma and the programme reflects emerging clinical questions tackled through a combination of cutting-edge methods. The overall aim of the…

Scientists have for the first time obtained stem cells from livestock that grow under chemically defined conditions, paving the way for manufacturing cell cultured meat and breeding enhanced livestock. Researchers from the University of Nottingham’s School of Biosciences, together with colleagues at the Universities of Cambridge, Exeter Tokyo and Meiji…

Computational design Protein modeling and design was performed with Rosetta version 3.5 (2015.19.57819)35,37. Python and shell scripts for generating input from Rosetta and analyzing from Rosetta are available at: github.com/raman-lab/biosensor_design The high-resolution TtgR structure co-crystalized with tetracycline was selected as the starting point for computational design (PDB: 2UXH)28. The structure…

cellranger count DETECT_COUNT_CHEMISTRY (failed) 0 I am learning scRNA-seq and the tutorial I follow uses dataset (1k pbmcs from healthy donor) from 10X genomics website. I downloaded fastq and reference transcriptome files and ran following command. cellranger-6.1.1/cellranger count –id pbmc_1k_v2_example –transcriptome /home/murat/Share/single_cell/refdata-gex-GRCh38-2020-A –fastqs /home/murat/Share/single_cell/pbmc_1k_v2_fastqs I get following message. Martian Runtime…

Short summary The position of Bioinformatics Training Developer will provide support to the bioinformatics training and development needs of research scientists primarily RNA-Seq, ATAC-Seq, ChiP-Seq and single-cell RNA-Seq. There are 2000 research scientists at the Francis Crick Institute. The role-holder will be located within the Bioinformatics and Biostatistics Core in…

Short summary The position of Bioinformatics Officer within the Bioinformatics Core Facility will provide primarily computational and bioinformatics expertise to support high throughput post-genomic technologies (next generation sequencers), within an informed biological context, not only for research scientists within the Francis Crick Institute but also for other members of the…

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Common medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially reducing the medications’ effectiveness. “If we can characterise how people respond depending on the composition of their microbiome, then drug treatments could be individualised,”Kiran Patil These interactions – seen for many drugs including…

Drug accumulation may reduce drug effectiveness and alter the gut microbiome Commonly used drugs accumulate in human gut bacteria, which can affect the drugs’ effectiveness and change the bacteria’s metabolism. Credit: Aleksandra Krolik Common medications can accumulate in gut bacteria, a new study has found, altering bacterial function and potentially…

Abstract A critical challenge for microbiology and medicine is how to cure infections by bacteria that survive antibiotic treatment by persistence or tolerance. Seeking mechanisms behind such high survival, we developed a forward-genetic method for efficient isolation of high-survival mutants in any culturable bacterial species. We found that perturbation of…