Tag: MRD

A familial SAMD9 variant present in pediatric myelodysplastic syndrome

Cold Spring Harb Mol Case Stud. 2023 Apr; 9(2): a006256. ,1,2 ,1,2 ,1,2 ,2,3 ,4 and 1,2 Mahvish Q. Rahim 1Pediatric Hematology Oncology, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA; 2Riley Hospital for Children at Indiana University Health, Indianapolis, Indiana, USA; April Rahrig 1Pediatric Hematology Oncology,…

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Personalized Residual Disease Assays Show Promise to Overcome Liquid Biopsy Challenges in Sarcomas

NEW YORK – New findings presented at the American Society of Clinical Oncology in Chicago this week have offered a glimpse into a potential future for blood-based minimal residual disease tests in patients with sarcomas, a challenging application for liquid biopsy technologies due to a lack of recurring or predictable…

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Cell-free DNA measurable residual disease as a predictor of postallogeneic hematopoietic cell transplant outcomes

The measurable residual disease (MRD) assessment provides an attractive predictor of alloHCT outcomes. Cell-free DNA (cfDNA) has been applied to diagnosis, early detection, and disease burden monitoring in various tumors but its utility as an MRD test in myeloid malignancies has not been systematically evaluated. We sought to determine the…

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CAR-T Therapy May Help Slow Multiple Myeloma Progression

Ciltacabtagene autoleucel (cilta-cel), a BCMA-targeting chimeric antigen receptor (CAR) T-cell therapy, may significantly slow or stop the progression of multiple myeloma (MM)  when compared with standard-of-care treatments among patients for whom lenalidomide no longer works, according to new data presented at the ASCO Annual Meeting 2023. The global, phase 3…

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ASCO: Moderna, Merck melanoma vaccine set for phase 3

Moderna’s move into personalised cancer therapy continues to proceed at a rapid pace, with Merck & Co-partnered melanoma vaccine mRNA-4157 heading for a pivotal phase 3 programme after a phase 2b data drop at ASCO. In the study, mRNA-4157 (V940) – which targets dozens of unique tumour-associated antigens or neoantigens…

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Split-dose R-CHOP regimen effective for older adults with newly diagnosed lymphoma

Source/Disclosures Published by: Source: Shah NN, et al. Abstract 7554. Presented at: ASCO Annual Meeting; June 2-6, 2023; Chicago. Disclosures: Adaptive Biotechnology and a grant from the Froedtert Foundation supported this study. Shah reports consultant/advisory board roles with, research funding/paid expenses from or stock ownership in Adaptive…

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Moderna and Merck Announce mRNA-4157 (V940) in Combination With KEYTRUDA(R) (pembrolizumab)

mRNA-4157 (V940) in combination with KEYTRUDA reduced the risk of distant metastasis or death by 65% (HR=0.347 [95% CI, 0.145-0.828]); one-sided p value=0.0063) compared to KEYTRUDA alone The DMFS results, a key secondary endpoint of the Phase 2b KEYNOTE-942 study, will be presented at the 2023 American Society of Clinical…

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Invivoscribe, Complete Genomics Partner to Develop, Commercialize Oncology Biomarker Tests

NEW YORK – Invivoscribe and Complete Genomics said on Friday that they have inked a worldwide partnership to develop and commercialize oncology biomarker tests using Complete Genomics’ next-generation sequencing platforms. Financial details of the agreement were not disclosed. As part of the collaboration, Invivoscribe will be responsible for the development…

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Invivoscribe, Complete Genomics partner to develop NGS tests for cancer research, detection

Invivoscribe and Complete Genomics said Friday that they are partnering to develop and commercialize biomarker tests. Under the terms of the deal, Invivoscribe will be responsible for the development of biomarker tests, including test controls and associated bioinformatics software. The tests will run on Complete Genomics’ next-generation sequencing (NGS) platforms….

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Adaptive Biotechnologies Highlights New Data at ASCO 2023

New data emphasizes the value of MRD testing in predicting survival outcomes and informing the personalized treatment of patients with hematologic cancers clonoSEQ continues to be the MRD test of choice for biopharma companies as evidenced in over a dozen investigational studies across multiple therapeutic approaches SEATTLE, June 02, 2023…

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Invivoscribe Partners with Complete Genomics to Develop and Commercialize Biomarker Tests for Oncology and Cancer Research

SAN DIEGO and SAN JOSE, Calif. , June 2, 2023 /PRNewswire/ — Invivoscribe and Complete Genomics announced today that they had entered a partnership to develop and commercialize biomarker tests on Complete Genomics’ NGS platforms. The territory is worldwide, and the field is oncology and cancer research. Under the terms…

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Precision BioSciences Provides Update on Allogeneic CAR T Programs and Regulatory Path Forward | DNA RNA and Cells

Precision BioSciences Provides Update on Allogeneic CAR T Programs and Regulatory Path Forward Details Category: DNA RNA and Cells Published on Thursday, 01 June 2023 10:51 Hits: 155 Azer-Cel Safety Profile was Significantly Improved Compared to Prior Cohorts in Patients Dosed Using Optimized Product at Lower Intensity Lymphodepletion; No Grade…

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Blood Test Detects Residual Disease For Adults With AML in Remission Prior to Bone Marrow Transplant

In 2020, there were more than 73,000 people living with acute myeloid leukemia (AML) in the United States. Approximately 31% of those with AML are estimated to survive 5 or more years after their diagnosis.1 Although a bone marrow transplant may increase that 5-year survival rate, the efficacy of the…

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Twist Bioscience Corporation (TWST) and CeGaT Launch RNA Fusion Panel to Advance Oncology and Precision Medicine Research

News and research before you hear about it on CNBC and others. Claim your 1-week free trial to StreetInsider Premium here. Twist Bioscience Corporation (NASDAQ: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, and CeGaT GmbH, a global provider of…

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DNA Printing, Bioengineered Kidney Constructs in Space, Revvity’s Big Pharma Agreements, More

May 24, 2023 | The Association for Molecular Pathology releases recommendations for germline variants detected by NGS, 10x Genomics wins German injunction against NanoString Technologies, and Revvity—formerly PerkinElmer—announces new license agreement with AstraZeneca. Plus new products and deployments from DNA Script, Thermo Fisher, Model N, GenScript, and more. Clear Labs…

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Pre-Transplant DNA Sequencing Suggests Association Between Persistence of Most-Common AML Variants and Poorer Outcomes in Patients with AML

Rates of relapse and worse survival were associated with persistent FLT3-ITD or NPM1 variants prior to allogeneic hematopoietic stem cell transplant for patients with acute myeloid leukemia. Detection by DNA sequencing of persistent FLT3-ITD or NPM1 variants – the two most common AML variants – in blood ahead of allogeneic hematopoietic cell transplantation (allo-HCT)…

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Personalis, Ono Pharmaceutical, Japan National Cancer Center Partner on Opdivo Rectal Cancer Trial

NEW YORK – Personalis said Tuesday that it has partnered with Ono Pharmaceutical and Japan’s National Cancer Center to assess its minimal residual disease platform in a study of Opdivo (nivolumab) in resectable rectal cancer with mismatch repair deficiency. Opdivo was jointly developed by Ono and Bristol Myers Squibb. During…

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Jury Awards Natera $19.4M in Damages in Invitae, ArcherDx Patent Infringement Suit

NEW YORK – A jury in the US District Court for the District of Delaware on Monday awarded Natera $19.4 million in damages for royalties and lost profits in a patent lawsuit against Invitae and ArcherDx. Specifically, the jury found that Invitae and ArcherDx products infringed upon Natera’s patents 10,557,172; 10,597,708; and 10,731,220;…

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Sarclisa plus Kyprolis found to stop cancer for nearly 3 years in trial | Combo delayed cancer progression in relapses, hard-to-treat cases

Sarclisa (isatuximab), given on top of standard treatment with Kyprolis (carfilzomib) and the steroid dexamethasone, was found to delay disease progression by almost three years, on average, in people with relapsed or refractory — hard-to-treat — multiple myeloma, according to updated data from a Phase 3 clinical trial. These results corresponded…

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Accuracy of minimal residual disease detection by circulating tumor DNA profiling in lung cancer: a meta-analysis | BMC Medicine

Ettinger DS, Wood DE, Aisner DL, Akerley W, Bauman JR, Bharat A, Bruno DS, Chang JY, Chirieac LR, D’Amico TA, et al. NCCN Guidelines Insights: Non-Small Cell Lung Cancer, Version 2.2021. J Natl Compr Canc Netw. 2021;19(3):254–66. Article  CAS  PubMed  Google Scholar  Aberle DR, Adams AM, Berg CD, Black WC,…

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IMUNON Reports First Quarter 2023 Financial Results and Provides Business Update

Non-Viral DNA-Mediated Immunotherapy and Next-Generation Vaccine Programs with Multiple Near-Term Milestones Supported by a Strong Balance Sheet Conference Call Begins Today at 11:00 a.m. EDT LAWRENCEVILLE, N.J., May 11, 2023 (GLOBE NEWSWIRE) — IMUNON, Inc. (NASDAQ: IMNN), a clinical-stage drug-development company focused on developing non-viral DNA-mediated immunotherapy and next-generation vaccines,…

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IMUNON Reports First Quarter 2023 Financial Results and

Non-Viral DNA-Mediated Immunotherapy and Next-Generation Vaccine Programs with Multiple Near-Term Milestones Supported by a Strong Balance Sheet Conference Call Begins Today at 11:00 a.m. EDT LAWRENCEVILLE, N.J., May 11, 2023 (GLOBE NEWSWIRE) — IMUNON, Inc. (NASDAQ: IMNN), a clinical-stage drug-development company focused on developing non-viral DNA-mediated immunotherapy and next-generation vaccines,…

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Isatuximab, carfilzomib, and dexamethasone in patients with relapsed multiple myeloma: updated results from IKEMA, a randomized Phase 3 study

Patients At data cut-off (January 14, 2022), the median follow-up was 44 months; 49 (27.4%) patients in the Isa-Kd arm and 11 (8.9%) in the Kd arm were still on treatment (Fig. 1). The most frequent reason for discontinuation in both arms was progressive disease, although it was less frequent…

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Genetic clues could predict leukemia patients’ risk of treatment failure

Treatment of T-ALL IF. (A) Swimmer plot displaying postinduction treatment of patients with IF split by trial. Standard chemotherapy indicates standard trial treatment. Nelarabine indicates nelarabine given either alone or in combination with other agents. High-dose chemotherapy indicates other non–nelarabine-containing regimens, most commonly FLA-IDA. (B) Kaplan-Meier plot showing OS of…

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PERSONALIS, INC. Management’s Discussion and Analysis of Financial Condition and Results of Operations. (form 10-Q)

The following discussion and analysis of our financial condition and results of operations should be read in conjunction with our condensed consolidated financial statements and the related notes and other financial information included elsewhere in this Quarterly Report on Form 10-Q and our Annual Report on Form 10-K for the…

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NuProbe BDA Technology Enables Highly Sensitive Detection

Houston, May 03, 2023 (GLOBE NEWSWIRE) — NuProbe, a genomics company developing ultrasensitive research assays for detecting and monitoring low-frequency mutations, gene fusions, and copy number alterations (CNAs), recently published research demonstrating capabilities of their blocker displacement amplification (BDA) technology for detection of a JAK2 mutation using qPCR. The research, done…

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Personalis to Test MRD Assay in Triple-Negative Breast Cancer Trial With ABRCC, Criterium

NEW YORK – Personalis said Tuesday that it has partnered with the Academic Breast Cancer Consortium (ABRCC) and Criterium to carry out a prospective clinical trial evaluating the clinical performance of its NeXT Personal test in patients with early-stage triple-negative breast cancer (TNBC). The firm’s assay, a tumor-informed blood test,…

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ChromaCode, MedGenome collaborate on multiplexing platform availability in India and the Middle East

Genomics company ChromaCode on Thursday announced a partnership with research and diagnostics company MedGenome to bring ChromaCode’s High Definition PCR (HDPCR) multiplexing technology to India and the Middle East. The HDPCR approach uses ChromaCode’s cloud-based analysis platform for deep multiplexing of actionable biomarkers in a single rapid assay for multiple…

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Uproleselan Combinations Contribute to Robust Investigational Profile in AML

Michael Andreeff, MD, PhD The E-selectin inhibitor uproleselan (GMI-1271) has shown preliminary efficacy in patients with acute myeloid leukemia (AML), and E-selectin could represent one of several novel targets for treatment of this patient population, according to Michael Andreeff, MD, PhD. Previously, a phase 1/2 trial (NCT02306291) investigating uproleselan plus…

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Redefining Cancer-Free With ctDNA | Technology Networks

Survivorship after the diagnosis and treatment of cancer is a uniquely uncertain state of being, one in which periods of relief are punctuated by uncertainty. Even while all indications suggest the cancer is gone, many patients can’t help but feel a sense of foreboding, as though the cancer had merely…

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Alercell Launches “Lena Molecular Diagnostic Leukemia Platform”

BOZEMAN, Mont., April 24, 2023 /PRNewswire/ — ALERCELL, INC. announced today that it has introduced a molecular Leukemia diagnostic platform. LENA Molecular Dx Leukemia Platform is a core group of 12 molecular diagnostic tests specialized in Leukemia early diagnostic, treatment guidance and MRD (Minimal residual disease) monitoring. All the tests…

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Abstract titled “First Phase 3 Results From CARTITUDE-4: Cilta-cel versus standard of care (PVd or DPd) in lenalidomide-refractory multiple myeloma” – Form 6-K

Background: CARTITUDE-4 is a global, phase 3, randomized, controlled trial (NCT04181827) of ciltacabtagene autoleucel (cilta-cel), a dual-binding, B-cell maturation antigen-targeting chimeric antigen receptor (CAR)-T cell therapy, versus (vs) standard of care (SOC; pomalidomide, bortezomib, and dexamethasone [PVd] or daratumumab, pomalidomide, and dexamethasone [DPd]) in lenalidomide-refractory patients. Aims: To report results…

Continue Reading Abstract titled “First Phase 3 Results From CARTITUDE-4: Cilta-cel versus standard of care (PVd or DPd) in lenalidomide-refractory multiple myeloma” – Form 6-K

C2i Genomics Expands Data on Whole-Genome Sequencing MRD Test in Colon, Lung Cancer

NEW YORK – Cancer detection and monitoring firm C2i this week shared a suite of new study results on its platform for minimal residual disease detection and monitoring using AI and whole-genome sequencing. The company, which launched as a joint venture between New York Genome Center (NYGC) and Weill Cornell…

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A Reliable Tool for Detecting Low-Level Residual Myeloma Immunoglobulin?

The following is a summary of “Reproducibility of low-level residual myeloma immunoglobulin detection using ultra-deep sequencing,” published in the March 2023 issue of Hematology by Cédile et al.  The second most prevalent hematologic malignancy is multiple myeloma, a neoplasm of mature B-cells. Despite the progress in therapeutic interventions, the ailment…

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DiaCarta Announces Five Abstracts Accepted for Presentation at AACR Annual Meeting 2023

DiaCarta, Ltd. Abstracts demonstrating XNA technology’s improvements to assay sensitivity across different technology platforms and support for use in companion diagnostics (CDx) assay development Additional abstracts to further support XNA technology’s potential for use in minimal residual disease (MRD) monitoring of residual cancer cells PLEASANTON, Calif., April 16, 2023 (GLOBE…

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Adela presents data demonstrating strong detection of 12 cancer types at the American Association for Cancer Research Annual Meeting 2023

Adela’s platform demonstrated strong detection for early stage cancers FOSTER CITY, Calif., April 16, 2023 /PRNewswire/ — Adela, Inc. presented data today demonstrating the ability of its genome-wide methylome enrichment platform to detect a broad set of diverse cancers in early stages (stage I and II), when treatment can be…

Continue Reading Adela presents data demonstrating strong detection of 12 cancer types at the American Association for Cancer Research Annual Meeting 2023

Determining the Optimal Frontline Regimen for Previously Untreated CLL

Matthew S. Davids, MD, MMSc The combination of acalabrutinib (Calquence) plus venetoclax (Venclexta) is being investigated for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL) in the phase 3 MAJIC study (NCT05057494).1  Multiple effective treatment regimens exist for patients with previously untreated CLL, but research has not…

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Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA

Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK Christopher Abbosh, Alexander M. Frankell, Selvaraju Veeriah, Sophia Ward, Kristiana Grigoriadis, Kevin Litchfield, Clare Puttick, Dhruva Biswas, Takahiro Karasaki, James R. M. Black, Carlos Martínez-Ruiz, Maise Al Bakir, Emilia L. Lim, Ariana Huebner, David A. Moore, Elizabeth Manzano, Crispin T. Hiley, Mariam Jamal-Hanjani, Abigail Bunkum, Antonia Toncheva, Corentin Richard, Cristina Naceur-Lombardelli, Foteini Athanasopoulou, Francisco Gimeno-Valiente, Haoran Zhai, Jie Min Lam, Kerstin…

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Takeda selects clonoSEQ Assay to assess minimal residual

The clonoSEQ Assay detects and quantifies specific DNA sequences found in malignant cells. Credit: mwooten from Pixabay. US-based Adaptive Biotechnologies (Adaptive) has formed a translational collaboration with Japanese pharmaceutical company Takeda to use its clonoSEQ Assay in the clinical trials across the latter’s haematologic malignancy portfolio. The collaboration will use…

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Mitochondrial Inheritance Following Nuclear Transfer: From Cloned Animals to Patients with Mitochondrial Disease

Rojansky R, Cha M-Y, Chan DC (2016) Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. eLife 5:e17896. doi.org/10.7554/eLife.17896 CrossRef  CAS  PubMed  PubMed Central  Google Scholar  Wei W, Pagnamenta AT, Gleadall N et al (2020) Nuclear-mitochondrial DNA segments resemble paternally inherited mitochondrial DNA…

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Collaborative breakthrough for rectal cancer patients

The preliminary results from a whole genome minimal residual disease (MRD) test were evaluated in 31 patients with locally advanced rectal cancer (LARC). C2i Genomics and Memorial Sloan Kettering performed a collaborative study as part of the Organ Preservation for Rectal Adenocarcinoma (OPRA) trial. The test was evaluated for the…

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DNA Sequencing Testing Used to Detect Residual AML Prior to Transplant

The use of high sensitivity DNA sequencing tests to measure residual disease in AML could improve identification of patients at risk for relapse or death. “In acute myeloid leukemia (AML), the association between measurable residual disease (MRD)—leukemic cells remaining in a patient during clinical remission but not detectable by standard…

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DNA Sequencing Prior to HCT Identifies Patients at Risk of Poor AML Outcomes

In patients with acute myeloid leukemia (AML) in first remission, the persistence of certain DNA variants related to measurable residual disease (MRD) prior to allogeneic hematopoietic cell transplant (HCT) was associated with post-HCT relapse and worse survival outcomes in a recent study. The findings, published in JAMA, suggest that the…

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Minimal residual disease monitoring in NSCLC

Background Cell-free DNA (cfDNA) refers to fragments of DNA released into the circulation by endothelial cells and white blood cells by active release or passively through apoptosis and necrosis.1,2 The fraction of cfDNA that originates from tumor is known as circulating tumor DNA (ctDNA). In 2016 the first commercial ctDNA…

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Effective Detection of MRD May Support Earlier Implementation of ctDNA Testing in CRC

Despite an initial increase in the amount of cell-free DNA (cfDNA) 2 weeks after surgery, high cfDNA levels do not negatively affect the accuracy of minimal residual disease (MRD) detection via circulating tumor DNA (ctDNA) in patients with colorectal cancer (CRC). This finding supports the earlier application of ctDNA testing,…

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A Randomized Phase II Trial of Brentuximab Vedotin (SGN35, NSC# 749710), or Crizotinib (NSC#749005, commercially labeled) in Combination with Chemotherapy for Newly Diagnosed Patients with Anaplastic Large Cell Lymphoma (ALCL)

Primary Objectives: -to determine the tolerability of brentuximab vedotin given in combination with standard chemotherapy (ALCL99) and to determine the tolerability of crizotinib given in combination with chemotherapy (ALCL99) to estimate the event free survival (EFS) of Arm BV and Arm CZ and contrast these to historical control data Secondary…

Continue Reading A Randomized Phase II Trial of Brentuximab Vedotin (SGN35, NSC# 749710), or Crizotinib (NSC#749005, commercially labeled) in Combination with Chemotherapy for Newly Diagnosed Patients with Anaplastic Large Cell Lymphoma (ALCL)

Single-cell individual full-length mtDNA sequencing by iMiGseq uncovers unexpected heteroplasmy shifts in mtDNA editing

doi: 10.1093/nar/gkad208. Online ahead of print. Chongwei Bi  1 , Lin Wang  1 , Yong Fan  2 , Baolei Yuan  1 , Gerardo Ramos-Mandujano  1 , Yingzi Zhang  1 , Samhan Alsolami  1 , Xuan Zhou  1 , Jincheng Wang  3 , Yanjiao Shao  4 , Pradeep Reddy  4 , Pu-Yao Zhang  5 , Yanyi Huang  3   6 , Yang Yu  5…

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IMUNON Reports 2022 Financial Results and Provides Business

Conference Call Begins Today at 11:00 a.m. Eastern Time LAWRENCEVILLE, N.J., March 30, 2023 (GLOBE NEWSWIRE) — IMUNON, Inc. (NASDAQ: IMNN), a clinical-stage drug-development company focused on developing DNA-mediated immunotherapy and next-generation vaccines, today announced financial results for the year ended December 31, 2022, and provided an update on its…

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Frontline Ibrutinib/Venetoclax Generates Prolonged uMRD Data in CLL

Carolyn Owen, MD, associate professor in the Division of Hematology & Hematological Malignancies, University of Calgary, and hematologist at the Tom Baker Cancer Center, discusses data from the phase 3 GLOW study (NCT03462719) which were presented at the 10th Annual Meeting of the Society of Hematologic Oncology (SOHO). The GLOW…

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NeoGenomics Announces Commercial Availability of the RaDaR(R) Molecular Residual Disease Test

PRESS RELEASE Published March 16, 2023 FT MYERS, FL / ACCESSWIRE / March 16, 2023 / NeoGenomics, Inc. (NASDAQ:NEO), a leading provider of oncology testing and global contract research services, announced today the commercial availability of the RaDaR® assay, a liquid biopsy test for molecular/minimal residual disease (MRD). MRD is…

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Researchers Aim to Boost Liquid Biopsy cfDNA Yields Using Novel Priming Agents

NEW YORK – Lipid nanoparticles that inhibit cellular uptake of cell-free DNA (cfDNA) and engineered antibodies that protect cfDNA from degradation are showing early success in boosting liquid biopsy cfDNA yields, which could eventually lead to improved cancer diagnostic and prognostic assays. Investigators from the Broad Institute and the Koch…

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ADC Therapeutics : Annual Report – Form 6-K

ADC Therapeutics SA 2022 Annual Report Table of Contents Letter to Shareholders Business Update Financial Review Corporate Governance Report from the Auditor on the Consolidated IFRS Financial Statements Consolidated IFRS Financial Statements for the Year Ended December 31, 2022 Report from the Auditor on the Statutory Financial Statements of ADC…

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ctDNA Testing in Colorectal Cancer Deemed Promising but Not Ready for Prime Time

Recent studies have suggested that circulating tumor DNA (ctDNA) testing has prognostic value in colorectal cancer, but researchers maintain that additional studies are needed to confirm whether and how ctDNA testing should be used in practice.  A study published in Nature Medicine showed that ctDNA testing can identify patients with…

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Cellectis Provides Business Update and Reports Fourth Quarter and Full Year 2022 Financial Results

Entered into a €40 million credit facility with the European Investment Bank and closed an approximatively $25 million follow-on equity offering to support Cellectis’ research, development and innovation activities Positive preliminary clinical data from Phase 1 BALLI-01 study (evaluating UCART22) for patients with r/r B-cell ALL presented…

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Blood-Based MRD Testing Identifies AML Patients at Risk of Relapse After Stem Cell Transplant

NEW YORK – Using DNA sequencing to detect measurable residual disease (MRD) in acute myeloid leukemia (AML) patients about to undergo a stem cell transplant can help predict who will have their disease recur, according to a new study by researchers at the US National Heart, Lung, and Blood Institute…

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Autolus Therapeutics Reports Full Year 2022 Financial Results and Operational Progress

Autolus Therapeutics plc Obe-cel, a potentially transformational treatment for relapsed/refractory (r/r) B-cell Acute Lymphoblastic Leukemia (ALL) met the primary endpoint in the pivotal Phase 2 FELIX study and is on track for next data update at a medical conference in mid-2023 with a Biologics License Application (BLA) submission to the…

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DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant

Importance: Preventing relapse for adults with acute myeloid leukemia (AML) in first remission is the most common indication for allogeneic hematopoietic cell transplant. The presence of AML measurable residual disease (MRD) has been associated with higher relapse rates, but testing is not standardized. Objective: To determine whether DNA sequencing to…

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Personalis, AstraZeneca Extend Collaboration Around Residual Cancer Detection Test

NEW YORK – Personalis said Tuesday that it is continuing a collaboration with AstraZeneca to explore the cancer sequencing firm’s Next Personal molecular residual disease (MRD) test in clinical research and drug development.  The two companies are evaluating the sensitivity and specificity of whole-genome-informed circulating tumor DNA testing that supports…

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Autolus Therapeutics Reports Full Year 2022 Financial

Obe-cel, a potentially transformational treatment for relapsed/refractory (r/r) B-cell Acute Lymphoblastic Leukemia (ALL) met the primary endpoint in the pivotal Phase 2 FELIX study and is on track for next data update at a medical conference in mid-2023 with a Biologics License Application (BLA) submission to the US FDA planned…

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Blood test identifies acute myeloid leukemia patients at greater risk for relapse after bone marrow transplant

News Release Tuesday, March 7, 2023 A small portion of adults in remission from a deadly blood cancer had persisting mutations that were detected, which predicted their risk of death from having the cancer return. Researchers at the National Institutes of Health show the benefits of screening adult patients in remission from acute…

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Early Data for Orca-T Cellular Therapy Provides Basis for Phase 3 Study in AML

The use of the precision cellular therapy Orca-T demonstrated promising efficacy effects at a median follow-up of 1 year in patients with acute leukemia or high-risk myelodysplastic syndrome (MDS) in an early analysis of a phase 1b and 2 study that have yet to be reported, according to data presented…

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Phase 3 Trial for Uproleselan in Relapsed/Refractory Acute Myeloid Leukemia to Continue Until OS Event Trigger

An independent data monitoring committee (IDMC) has recommended that a phase 3 trial (NCT03616470) evaluating uproleselan (GMI-1271) plus chemotherapy for patients with relapsed/refractory acute myeloid leukemia (AML) should continue to the planned overall survival (OS) event trigger.1 The IDMC conducted an interim utility analysis using a very high statistical threshold…

Continue Reading Phase 3 Trial for Uproleselan in Relapsed/Refractory Acute Myeloid Leukemia to Continue Until OS Event Trigger

Adaptive Biotechnologies Lays out Strategy to Drive ClonoSeq Adoption

NEW YORK – Calling its minimal residual disease (MRD) business “firing on all cylinders,” Adaptive Biotechnologies on Tuesday laid out a multitiered strategy to help expand utilization of its ClonoSeq MRD assay in lymphoid cancer patients. “To further increase ClonoSeq penetration, we are focused on a three-pronged strategy,” Adaptive CEO…

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Bridging biological cfDNA features and machine learning approaches: Trends in Genetics

Early detection (pancreatic cancer) cfMeDIP-seq, 5hmC sequencing LR elastic-net Hierarchical clustering, t-SNE, LR with elastic-net penalization Methylation (5mC-5hmC) 208 (72/136) 24-feature 5mC, 27-features 5hmC, 51-features combined model SML, UML Combined 5mC and 5hmC AUC of 0.997 (sensitivity 0.938, specificity 0.955) Median total reads: 17.4 M, 0.8 nonduplicate mapping rate pms.cd120.com/PDAC/index.html…

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In-depth circulating tumor DNA sequencing for prognostication and monitoring in natural killer/T-cell lymphomas

Background Extranodal natural killer/T-cell lymphoma (ENKTL) is an aggressive subtype of non-Hodgkin lymphoma and the Epstein–Barr virus (EBV), which is believed to play an important role in lymphomagenesis (1), is usually detected in malignant cells. Despite an improvement in treatment strategies including non-anthracycline-based chemotherapy, the disease recurs or progresses in…

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JCM | Free Full-Text | Can Liquid Biopsy Based on ctDNA/cfDNA Replace Tissue Biopsy for the Precision Treatment of EGFR-Mutated NSCLC?

J. Clin. Med. 2023, 12(4), 1438; doi.org/10.3390/jcm12041438 (registering DOI) J. Clin. Med. 2023, 12(4), 1438; doi.org/10.3390/jcm12041438 (registering DOI) Received: 25 October 2022 / Revised: 16 January 2023 / Accepted: 6 February 2023 / Published: 10 February 2023 Round 1 Reviewer 1 Report Dear Authors,Thank you for an interesting review. Please find attached…

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Richters and DLBCL after CLL in 2013

Richters and DLBCL after CLL in 2013 After CLL diagnosed in 2013, unmutated, Trisomie 12, CD 38 neg., started FCR 6 cycles in Uni Clinic Cologne (Prof Hallek) up to 4/2014. MRD neg and CR. Then 9 years without therapy living well, no side effects. Now, in Oct 2023 the…

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Review of Molecular Testing Options in Metastatic Colorectal Cancer

Expert oncologists review key updates regarding metastatic colorectal cancer from recent meetings and discuss their implications on real-world clinical practice. At a recent Around the Practice program hosted by CancerNetwork®, experts discussed the use of molecular and genetic testing to better treat patients with metastatic colorectal cancer (CRC). The panel…

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Monitoring ctDNA After Colorectal Cancer Surgery

SAN FRANCISCO — In patients who have undergone surgery for colorectal cancer, monitoring levels of circulating tumor DNA (ctDNA) in the weeks after the operation can provide prognostic information.  For example, patients who showed ctDNA positivity during the molecular residual disease (MRD) time window of 2-8 weeks and during surveillance…

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Next-Generation Sequencing in Precision Oncology: Detecting Minimal Residual Disease

Like most diseases, cancer does not have a one-treatment-cures-all solution. Patients with the same type of cancer can respond very differently to the same treatment, or respond differently over time, necessitating more personalized treatment plans. The development of next-generation sequencing (NGS) has made the sequencing of patient tissues or tumors…

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Dr. Cohen on the Timing of ctDNA Testing in Resected Stage I-III CRC

Stacey A. Cohen, MD, associate professor, the Clinical Research Division, Fred Hutchinson Cancer Center, assistant professor, the Division of Oncology, the University of Washington, discusses the investigation of the optimal timing to test for circulating tumor DNA (ctDNA) to detect minimal residual disease (MRD) following surgery in patients with stage…

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Integrated DNA Technologies Expands Access, Expedites Turnaround Time, for Minimal Residual Disease (MRD) Solutions for Cancer Research

CORALVILLE, Iowa–(BUSINESS WIRE)–To help researchers accurately measure circulating tumor DNA (ctDNA) from the most degraded and low-input samples, Integrated DNA Technologies today launched a complete MRD workflow for tumor-informed approaches. The launch expands access to IDT’s xGen MRD Hybridization Panel and xGen cfDNA & FFPE DNA Library Preparation Kit, which…

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Daratumumab Plus RVd Improved Responses for Older and Some High-Risk Patients Compared With Triplet Alone in Newly Diagnosed MM

Key subgroups of patients with newly diagnosed, transplant-eligible multiple myeloma (NDMM) who were treated with daratumumab and a well-known triplet regimen had improved responses—including progression free-survival (PFS)—compared with similar patients receiving only the triplet, according to a post hoc analysis of the phase 2 GRIFFIN study (NCT02874742).1 The analysis, which…

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NY Genome Center Team Harnesses Ultima Genomics Platform for High-Sensitivity ctDNA Sequencing

BALTIMORE – Researchers from the New York Genome Center and Weill Cornell Medicine and their collaborators have demonstrated the utility of Ultima Genomics’ sequencing platform for sensitive blood-based cancer monitoring, using whole-genome error-corrected sequencing of circulating cell-free DNA (ccfDNA) at high coverage. In a preprint posted on BioRxiv last year, the…

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Geneseeq receives CE Marks for MRD and MCED tests

TORONTO, Jan. 24, 2023 /PRNewswire/ -Geneseeq Technology Inc. announced that Geneseeq’s multi-cancer minimal residual disease detection (MRD) and multi-cancer early detection (MCED) kits were both CE Marked for liquid biopsy use in solid tumor patients. Geneseeq Logo (CNW Group/Geneseeq Technology Inc.) The markings will enable Geneseeq to expand its global…

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cfDNA May Help Risk-Stratify Patients With ALL

Investigators say they have uncovered a potential new biomarker that could help physicians better assess the risk of relapse in patients treated for acute lymphoblastic leukemia (ALL). This new method relies on the analysis of cell-free DNA (cfDNA) to detect the presence of ALL in patients, which investigators say could…

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MorphoSys Presents Updated Tafasitamab Results in Newly Diagnosed DLBCL Patients from Final firstMIND Analysis at ASH 2022

EQS-News: MorphoSys AG / Key word(s): Miscellaneous MorphoSys Presents Updated Tafasitamab Results in Newly Diagnosed DLBCL Patients from Final firstMIND Analysis at ASH 2022 10.12.2022 / 23:01 CET/CESTThe issuer is solely responsible for the content of this announcement. Media Release   PLANEGG/MUNICH, Germany, December 10, 2022   MorphoSys Presents Updated Tafasitamab…

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Chimeric antigen receptor T cell therapy for cancer: clinical applications and practical considerations

Joseph E Maakaron, assistant professor of medicine, Marie Hu, assistant professor of medicine, Najla El Jurdi, assistant professor of medicine University of Minnesota Twin Cities, Minneapolis, United States Correspondence to: maaka001{at}umn.edu Abstract Chimeric antigen receptor T cells have revolutionized the treatment of hematological malignancies during the past five years, boasting…

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A desirable transgenic strategy using GGTA1 endogenous promoter-mediated knock-in for xenotransplantation model

Lai, L. et al. Production of alpha-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295, 1089–1092. doi.org/10.1126/science.1068228 (2002). ADS  CAS  Article  PubMed  Google Scholar  Kuwaki, K. et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat. Med. 11, 29–31. doi.org/10.1038/nm1171 (2005). CAS  Article  PubMed  Google…

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cfDNA-Based NGS IG Analysis in Lymphoma

Circulating cell-free DNA (cfDNA) is fragmented extracellular DNA, which is released from apoptotic and necrotic cells in small fragments of <200 bp [1]. cfDNA is typically isolated from the blood stream; however, it is also possible to detect cfDNA in other biological fluids such as urine or cerebrospinal fluid [2, 3,…

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Fortis Life Sciences Inks Distribution Deal for AccuGenomics NGS Standards Tech

NEW YORK — Fortis Life Sciences, a provider of capital and other resources to life science tool companies, said on Tuesday that it has signed a deal to distribute AccuGenomics’ SNAQ-SEQ internal standards technology for next-generation sequencing in the US and Europe. Under the terms of the deal, Waltham, Massachusetts-based…

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Anti-CD19 CAR T-Cell Therapy for B-Cell Lymphoma

Researchers reported a favorable efficacy and manageable safety profile in anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for adults with B-cell lymphomas. Their data is presented in Frontiers in Genetics. Researchers, led by Wenyujing Zhou, aimed to determine the benefits and risks of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy…

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h2o AutoML vs h2o XGBoost – model metrics

The problem here is that you are comparing training metrics for XGBoost to CV metrics for AutoML models. The code you posted for the manual XGBoost models provides training metrics. Instead, you will need to grab the CV metrics if you want to make a fair comparison to the performance…

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MRD Surveillance in DLBCL – Capsule Summary Slidesets – Lymphomas and CLL – 2021 ASH Annual Meeting – Oncology

December 11-14, 2021; Atlanta, Georgia Results of this study showed that substantial proportions of clinical relapses were radiographically detected in asymptomatic patients, whereas immunosequencing MRD monitoring demonstrated suboptimal sensitivity. Format: Microsoft PowerPoint (.ppt) File Size: 484 KB Released: December 16, 2021 …

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Exact Sciences and National Surgical Adjuvant Breast and Bowel Project Announce Clinical Validation Study to Detect Minimal Residual Disease in Colorectal Cancer Patients

“Our longstanding relationship with the NSABP, through our work to develop and validate the Oncotype DX Breast Recurrence Score® and Colon Recurrence Score® tests, represents a remarkable collaboration between academic and industry partners. This relationship has fueled major advancements in understanding the role of molecular profiling in breast and colon…

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Novel Test Distinguishes Benign From Malignant Lesions in NF1

A novel liquid biopsy test has been shown to distinguish between patients with neurofibromatosis type 1 (NF1) who have benign plexiform neurofibroma (PN) precursor lesions from patients who have malignant peripheral nerve sheath tumors (MPNST), say authors of a multi-institutional cross-sectional study. “Transformation from PN to MPNST is challenging to…

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Oncogene Concatenated Enriched Amplicon Nanopore Sequencing for rapid, accurate, and affordable somatic mutation detection | Genome Biology

Stochastic Amplicon Ligation. DNA samples for oncology sequencing are typically extracted from FFPE tissues and can have average lengths of less than 500 nt due to accumulated chemical damage [18]. We developed the Stochastic Amplicon Ligation (SAL) method to enzymatically concatenate many short DNA molecules together to utilize the long-read…

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Dissecting Cancer with Single-cell DNA Sequencing & Multi-omics | Learning Center

CANCER & SINGLE-CELL ANALYSIS The heterogeneity and dynamism of cancer present formidable challenges to understanding and treating the disease. As discussed in the last section, tumor evolution often leads to considerable genetic variation across clones. But the complexity of tumors does not stop at the level of DNA. Intratumoral phenotypic…

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