Tag: mRNA

Creative Bioarray Built Professional Cell Reprogramming Services with Cutting-edge Technologies to Accelerate Drug Development and Research

Creative Bioarray announced the release of its professional cell reprogramming services with cutting-edge technologies to accelerate drug development and research. New York, USA – January 24, 2022 – Cell culture platform, the division of Creative Bioarray, focuses on developing complete cell culture solutions with plenty of choices for the next…

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Seven technologies to watch in 2022

The Telomere-to-Telomere Consortium is sequencing whole chromosomes.Credit: Adrian T. Sumner/SPL From gene editing to protein-structure determination to quantum computing, here are seven technologies that are likely to have an impact on science in the year ahead. Fully finished genomes Roughly one-tenth of the human genome remained uncharted when genomics researchers…

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Image2_Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma.TIF

Background: Circular RNAs (circRNAs) have been demonstrated to be closely related to the carcinogenesis of human cancer in recent years. However, the molecular mechanism of circRNAs in the pathogenesis of hepatocellular carcinoma (HCC) has not been fully elucidated. We aimed to identify critical circRNAs and explore their potential regulatory network…

Continue Reading Image2_Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma.TIF

An eQTL variant of ALDH1A2 is associated with Kashin-Beck disease in Chinese population

Introduction: The aims of the study were to investigate the relationship between aldehyde dehydrogenase 1 family member A2 (ALDH1A2) and Kashin-Beck disease (KBD), explore the effects of the rs3204689 polymorphism and methylation status on the expression levels of ALDH1A2, and further clarify the pathogenesis of KBD. Materials and methods: The…

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[Solved] Sanger products using ddGTP Mononucleotide Decanucleotide Trinucleotide 12-nucleotide Tetranucleotide 13-nucleotide Pentanucleotide 14-nucle…

A Sanger product of the sequencing of a template DNA is presented… A Sanger product of the sequencing of a template DNA is presented below. Determine the sequence of template DNA and the mRNA sequence from this template DNA. Briefly explain.  Image transcription text Sanger products using ddGTP Mononucleotide Decanucleotide…

Continue Reading [Solved] Sanger products using ddGTP Mononucleotide Decanucleotide Trinucleotide 12-nucleotide Tetranucleotide 13-nucleotide Pentanucleotide 14-nucle…

A cell-based phenotypic library selection and screening approach for the de novo discovery of novel functional chimeric antigen receptors

Cell lines and culture Unless stated otherwise, all tumor target cell lines were sourced from the ATCC via LGC Standards. Human endogenous mesothelin (MSLN)-positive target cell lines H-226 (lung carcinoma, MSLN+, ATCC® CRL-5826™) and AsPC-1 (ATCC CRL-1682), and MSLN-negative Raji control cells (ATCC CCL-86) were cultured in RPMI-1640 Glutamax (Life Technologies,…

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Pluristyx, panCELLa, and Implant Therapeutics Announce a Strategic Alliance to Manufacture and Distribute Genetically Modified, Clinical-grade Human-induced Pluripotent Stem Cells

SEATTLE–(BUSINESS WIRE)–Pluristyx, Inc., an advanced therapy tools and services biotechnology company, panCELLa, a privately held biotechnology company, and Implant Therapeutics, a developer of genetically engineered stem cells, today announced they have entered into a manufacturing and distribution strategic alliance that offers cell therapy companies streamlined access to the next generation…

Continue Reading Pluristyx, panCELLa, and Implant Therapeutics Announce a Strategic Alliance to Manufacture and Distribute Genetically Modified, Clinical-grade Human-induced Pluripotent Stem Cells

Expression of the DNA repair gene XRCC1 in baboon tissues

doi.org/10.1016/0165-7992(95)00053-4Get rights and content Abstract XRCC1 is a DNA repair gene involved in rejoining DNA strand-breaks. We used baboon as an animal model to determine the levels of XRCC1 gene expression in different tisues. Baboons were selected because they are evolutionarily closely related to humans. A single 2.2 kb transcript…

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Functioning induced liver cells from skin tissue

Figure 1. Urea metabolism is impaired in patient-derived human-induced pluripotent stem cells (hiPSCs) differentiated into hepatocytes (hiPSC-Heps). (A) Scheme showing the urea cycle detoxifying ammonia (NH4+) into nontoxic urea in five consecutive urea cycle enzyme (UCE)–mediated reactions in mitochondria in hepatocytes. (B) Urea secretion in four control hiPSC-Hep lines (Ctrl_1-4)…

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Time-course RNASeq of Camponotus floridanus forager and nurse ant brains indicate links between plasticity in the biological clock and behavioral division of labor | BMC Genomics

1. Sharma VK. Adaptive significance of circadian clocks. Chronobiol Int. 2003;20(6):901–19. PubMed  Google Scholar  2. Paranjpe DA, Sharma VK. Evolution of temporal order in living organisms. J Circadian Rhythms. 2005;3(1):7. PubMed  PubMed Central  Google Scholar  3. Yerushalmi S, Green RM. Evidence for the adaptive significance of circadian rhythms. Ecol Lett….

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Failure to detect mutations in U2AF1 due to changes in the GRCh38 reference sequence

Materials and Methods Genomic data was collected as part of the MDS National History Study or The Cancer Genome Atlas project and consented appropriately under those protocols 8 Sekeres M.A. Gore S.D. Stablein D.M. DiFronzo N. Abel G.A. DeZern A.E. Troy J.D. Rollison D.E. Thomas J.W. Waclawiw M.A. Liu J.J….

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RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder

Significance Hairpin pyrrole-imidazole (Py-Im) polyamides can be programmed to bind a broad repertoire of DNA sequences. Py-Im small molecules can be used to target cancer-specific coding regions and block transcription elongation. This transcription blockage by Py-Im cannot be rescued by transcription elongation factors, such as TFIIS. The mechanism by which…

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Floxed exon (Flexon): A flexibly positioned stop cassette for recombinase-mediated conditional gene expression

Significance Tools that afford spatiotemporal control of gene expression are crucial for studying genes and processes in multicellular organisms. Stop cassettes consist of exogenous sequences that interrupt gene expression and flanking site-specific recombinase sites to allow for tissue-specific excision and restoration of function by expression of the cognate recombinase. We…

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Identification of a regulatory pathway inhibiting adipogenesis via RSPO2

Integration of APC scRNA-seq data reveals heterogeneity of adipocyte progenitor cells In a previous study9, we defined Lin−Sca1+CD142+ APCs as adipogenesis regulatory (Areg) cells and demonstrated that these cells are both refractory toward adipogenesis and control adipocyte formation of APCs through paracrine signaling. In contrast, Merrick et. al.4 observed that Lin−CD142+ cells…

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The role of ATXR6 expression in modulating genome stability and transposable element repression in Arabidopsis

Significance The plant-specific H3K27me1 methyltransferases ATXR5 and ATXR6 play integral roles connecting epigenetic silencing with genomic stability. However, how H3K27me1 relates to these processes is poorly understood. In this study, we performed a comprehensive transcriptome analysis of tissue- and ploidy-specific expression in a hypomorphic atxr5/6 mutant and revealed that the…

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An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes

Conflicting results suggest a missing variant In order to narrow down candidates for the causal genetic variant, we performed genome-wide association mapping separately in individual lake populations (previously, association mapping was only performed across the whole species flock5). Interestingly, despite clear association peaks in the crater lakes (Fig. 1a, b), the…

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Predicting sepsis severity at first clinical presentation: The role of endotypes and mechanistic signatures

Summary Background Inter-individual variability during sepsis limits appropriate triage of patients. Identifying, at first clinical presentation, gene expression signatures that predict subsequent severity will allow clinicians to identify the most at-risk groups of patients and enable appropriate antibiotic use. Methods Blood RNA-Seq and clinical data were collected from 348 patients…

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EXAM 2.docx – EXAM 2 1 In the Stringent Response bacterial rRNA tRNA and protein synthesis temporarily cease in response to depleted nutrients in the

EXAM 21.In the Stringent Response, bacterial rRNA, tRNA, and protein synthesis temporarilycease in response to depleted nutrients in the cell. The stringent response is initiated inthe cell due to:a.an excess of aminoacyl-tRNA that accumulates due to a block in translationb.accumulation of cyclic-AMP in the cellc.metabolite inhibition of isoenzyme function in…

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Genome research: Finding the invisible

Fig. 1: Ladder-seq uses mRNA length information to aid transcriptome reconstruction. Credit: DOI: 10.1038/s41587-021-01136-7 LMU researchers have developed a method to extract more information from sequencing data. This will afford deeper insights into biology. Higher organisms store their genetic material in the nuclei of cells as deoxyribonucleic acid (DNA). In…

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EPCAM – PrimePCR Assay and Template | Life Science

Control assays and synthetic DNA templates were designed to facilitate the assessment of the key experimental factors impacting your real-time PCR results. DNA Contamination Control AssayUse the PrimePCR DNA contamination control assay to determine if genomic DNA (gDNA) is present in a sample at a level that may affect PCR…

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Immune-related Prognostic Genes of ccRCC

Introduction Kidney cancer is one of the most commonly diagnosed tumors around the globe.1 According to the statistics from the World Health Organization, annually, there are more than 140,000 RCC-related deaths.2 ccRCC is the most typical subtype of kidney cancer and contributes to the majority of kidney cancer-related deaths.3,4 Until…

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The Genetic Architecture of Sleep Health Scores in the UK

Introduction Sleep is a complex neurological and physiological state. It is defined as a natural and reversible state of reduced responsiveness to external stimuli and relative inactivity, accompanied by a loss of consciousness.1 Sleep disorders can be classified as seven major categories: insomnia disorders, sleep-related breathing disorders, central disorders of…

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Identification of differentially expressed genes in AF

Defeng Pan,1,* Yufei Zhou,2,* Shengjue Xiao,1,* Yue Hu,3,* Chunyan Huan,1 Qi Wu,1 Xiaotong Wang,1 Qinyuan Pan,1 Jie Liu,1 Hong Zhu1 1Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221004, People’s Republic of China; 2Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of…

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16S rRNA, One of the Most Important rRNAs

The 16S rRNA and 18S rRNA genes are the most frequently used targets for bacteria/archaea and eukaryotes, respectively. Based on the diversity of ribosomal RNA sequences, one can explore the structure of the microbiome in terms of presence and relative abundance. prok. -30S -50S What are the functional components of…

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Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLYP regulates type I interferon innate immunity

Significance Interferon (IFN)-mediated antiviral responses serve as the first line of the host innate immune defense against viral infection. Here we identify a previously uncharacterized protein designated phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein (PINLYP), which is essential for embryonic development and plays an important role in type I IFN…

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Comprehensive Analysis of mRNA, lncRNA, circRNA, and miRNA Expression Profiles and Their ceRNA Networks in the Longissimus Dorsi Muscle of Cattle-Yak and Yak

doi: 10.3389/fgene.2021.772557. eCollection 2021. Chun Huang  1 , Fei Ge  1 , Xiaoming Ma  1 , Rongfeng Dai  1 , Renqing Dingkao  2 , Zhuoma Zhaxi  3 , Getu Burenchao  3 , Pengjia Bao  1 , Xiaoyun Wu  1 , Xian Guo  1 , Min Chu  1 , Ping Yan  1 , Chunnian Liang  1 Affiliations Expand Affiliations 1 Key Laboratory of…

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There are 4 types of RNA: mRNA, rRNA, sRNA, and tRNA.

Home There are 4 types of RNA: mRNA, rRNA, sRNA, and tRNA. There are 4 types of RNA: mRNA, rRNA, sRNA, and tRNA. This is a List of Available Answers Options : False True The best answer is A. False. Reported from teachers around the world. The correct answer to ❝There…

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Postdoc Position in Bioinformatics in Stem Cell Neurobiology

DepartmentDepartment of Histology and Embryology  – Faculty of MedicineDeadline 28 Feb 2022Start date Jully 2022Job type full-timeJob field Science and research Medical Faculty of Masaryk University, Brno, Czech Republic, invites excellent scientists to apply for Postdoc position in Bioinformatics in Stem Cell Neurobiology   Description: The Department of Histology and Embryology is…

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Bioinformatics Engineer/Senior Engineer – Cambridge Massachusetts

Flagship Pioneering has launched a privately held, biotechnology company that is pioneering novel diagnostics for cancer. This new company, Harbinger Oncology, is a highly dynamic, entrepreneurial, and innovation-driven organization seeking to hire a Bioinformatics Engineer/Senior Engineer to join our team. Flagship Pioneering conceives, creates, resources, and grows first-in-category life sciences…

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Bioinformatics analysis of long non-coding RNA-associated competing endogenous RNA network in schizophrenia

1. Marder, S. R. & Cannon, T. D. Schizophrenia. N. Engl. J. Med. 381, 1753–1761. doi.org/10.1056/NEJMra1808803 (2019). Article  PubMed  CAS  Google Scholar  2. Keshavan, M. S. et al. Neuroimaging in Schizophrenia. Neuroimaging Clin. N. Am. 30, 73–83. doi.org/10.1016/j.nic.2019.09.007 (2020). Article  PubMed  Google Scholar  3. McCutcheon, R. A., Reis Marques, T….

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p57 Suppresses the Pluripotency and Proliferation of Mouse Embryonic Stem Cells by Positively Regulating p53 Activation

Embryonic stem cells (ESCs) are pluripotent stem cells that have indefinite self-renewal capacities under appropriate culture conditions in vitro. The pluripotency maintenance and proliferation of these cells are delicately governed by the concert effect of a complex transcriptional regulatory network. Herein, we discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor…

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Postdoc Position in Bioinformatics in Stem Cell Neurobiology job with MASARYK UNIVERSITY

Department Department of Histology and Embryology – Faculty of Medicine Deadline 28 Feb 2022 Start date Jully 2022 Job type full-time Job field Science and research Medical Faculty of Masaryk University, Brno, Czech Republic, invites excellent scientists to apply for Postdoc position in Bioinformatics in Stem Cell Neurobiology   Description: The Department of…

Continue Reading Postdoc Position in Bioinformatics in Stem Cell Neurobiology job with MASARYK UNIVERSITY

Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice

O304 treatment prevents islet gene expression signature changes induced by HFD We have previously demonstrated that the AMPK activator O304 improves blood glucose homeostasis in both human T2D subjects as well as in high-fat diet induced obese and diabetic mouse models. In the present study, we have now analysed the…

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Omics advanced 07 | transcriptome mRNA | miRNA | lncrna

A brief introduction mRNA,miRNA,lncRNA And circRNA Principle of genome sequencing 、 Routine analysis of Shengxin . Catalog Introduction to transcriptome sequencing mRNA|miRNA|lncRNA|circRNA Introduction to analysis mRNA Group miRNA Group lncRNA Group circRNA Group mRNA|miRNA|lncRNA|circRNA Correlation analysis Reference Introduction to transcriptome sequencing Transcriptome (Transcriptome) Is a single or group of cells…

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GSA – Galaxy Community Hub

Galaxy-GSA – Galaxy Community Hub ← Platform Directory comments Gene Set Analysis (GSA) can be defined as the comparison of a query gene set (a list or a rank of differentially expressed genes, for example) to a reference database of annotated gene sets, in order to interpret the initial query…

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Mechanism for DNA invasion of adenoviral Covi

image: Incoming adenovirus particles (AdV) dock at the nuclear pore complexes of a human cell’s nucleus (NPC, dashed line). The cellular enzyme Mind bomb1 (Mib1, grey-white structures) primes them for unlocking and removes protein V (GFP-V, green dots). The uncoated viral DNA genome is then imported into the nucleus. The arrow…

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BioSpace hiring Scientist II – Bioinformatics in Cambridge, Massachusetts, United States

Job DescriptionJob SummaryThis position will be responsible for computational analyses on our novel mRNA vaccine platform to characterize novel antigens and evaluate subsequent vaccine responses. This position will work to analyses complex datasets and assist in experimental design to ensure rigorous statistical integrity. This position work collaboratively with other computational…

Continue Reading BioSpace hiring Scientist II – Bioinformatics in Cambridge, Massachusetts, United States

Identification of estrogen receptor beta expression in Chinese hamster ovary (CHO) cells and comparison of estrogen-responsive gene transcription in cells adapted to serum-free media

doi.org/10.1016/S0960-0760(03)00250-4Get rights and content Abstract Most cultured cell lines require addition of serum to the medium to maintain their proliferative capacity. For studies examining the cellular effects of estrogens serum is charcoal-stripped to remove steroids. Nonetheless, addition of the selective estrogen receptor modulator (SERM) 4-hydroxytamoxifen (4-OHT) inhibits the basal transcriptional…

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17q12-21 risk-variants influence cord blood immune regulation and multitrigger-wheeze

Background: Childhood wheeze represents a first symptom of asthma. Early identification of children at risk for wheeze related to 17q12-21 variants and their underlying immunological mechanisms remain unknown. We aimed to assess the influence of 17q12-21 variants and mRNA-expression at birth on development of wheeze. Methods: Children were classified as…

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Adrenal aldosterone-producing adenoma | IJGM

Background Primary hyperaldosteronism (PA) is characterized by spontaneous secretion of excessive aldosterone and inhibition of plasma renin activity.1 The pathogenesis of adrenal aldosterone-producing adenoma (APA) involves the abnormal proliferation of adrenal cortex cells and the excessive secretion of aldosterone, accounting for nearly 30% of PA. Excessive secretion of aldosterone can…

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Systems biology analysis of human genomes points to key pathways conferring spina bifida risk

Significance Genetic investigations of most structural birth defects, including spina bifida (SB), congenital heart disease, and craniofacial anomalies, have been underpowered for genome-wide association studies because of their rarity, genetic heterogeneity, incomplete penetrance, and environmental influences. Our systems biology strategy to investigate SB predisposition controls for population stratification and avoids…

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Establishment of sunitinib-resistant CDX model of ccRCC

Introduction Renal cell carcinoma (RCC) accounts for approximately 2–3% of all malignant tumors, and its prevalence is rising. Metastatic RCC accounts for 25–30% of all RCC cases, and has an exceedingly poor prognosis.1 In 2020, among approximately 430,000 newly discovered cases of RCC, 179,000 died.2 Clear cell renal cell carcinoma…

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Chitosan Nanoparticles for Antiviral Drug Delivery

Introduction According to research conducted in many labs in the field of nanotechnology, particularly in nanomedicine, it appears that nanotechnology and nanomedicine should play an active role in treating and preventing the spread of Coronavirus Infectious Disease-19 (COVID-19).1–6 Polymeric nanoparticles, such as chitosan NPs,7 are one of the possibilities available…

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Human Cytomegalovirus UL138 Protein Inhibits the STING Pathway and Reduces Interferon Beta mRNA Accumulation during Lytic and Latent Infections

doi: 10.1128/mBio.02267-21. Online ahead of print. Affiliations Expand Affiliations 1 Institute for Molecular Virology, University of Wisconsin-Madison, Madison, Wisconsin, USA. 2 McArdle Laboratory for Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, USA. Item in Clipboard Emily R Albright et al. mBio. 2021. Show details Display options Display options Format AbstractPubMedPMID doi:…

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Human microRNA inhibits expression of pathogenic gene underlying facioscapulohumeral muscular dystrophy

Fig. 1: miR-675 targets the DUX4 ORF and 3′UTR. a RenLuc-DUX4-FL dual-luciferase reporter and CMV.H19 constructs, and U6.MIR675, H1.MIR675, U6.MIR675-3p, and U6.MIR675-5p miRNAs. RenLuc-DUX4-FL contains DUX4 ORF and 3′UTR sequences fused to Renilla luciferase after the stop codon. Exons 1–3 are indicated (Ex1,2,3). *SD5 indicates silent mutation of a cryptic…

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Graph clustering as a method to investigate riboswitch variation

Abstract Non-coding RNA (ncRNA) perform vital functions in cells, but the impact of diversity across structure and function of homologous motifs has yet to be fully investigated. One reason for this is that the standard phylogenetic analysis used to address these questions in proteins cannot easily be applied to ncRNA…

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ncRNA | Free Full-Text | Common Features in lncRNA Annotation and Classification: A Survey

CONC 2006 SVM Eukaryotes (both protein-coding and non-coding genes) peptide length, amino acid composition, predicted secondary structure content, mean hydrophobicity, percentage of residues exposed to solvent, sequence compositional entropy, number of homologues, alignment entropy 10-fold CV on protein-coding: F1-score: 97.4% ☼ Precision: 97.1% ☼ Recall: 97.8% ◙ On non-coding: F1-score:…

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Vincerx Pharma Presents Data o

VIP152 has increased selectivity and potency compared to other CDK9 inhibitors in development, consistent across DLBCL and CLL models of disease Vincerx hosting KOL webinar today, Saturday, December 11, 2021, at 7:30pm EST PALO ALTO, Calif., Dec. 11, 2021 (GLOBE NEWSWIRE) — Vincerx Pharma, Inc. (Nasdaq: VINC) a biopharmaceutical company…

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[Analysis of the Differential Expression of circRNA in Acute Myeloid Leukemia by GEO Database]

Objective: To investigate the difference expression of circular RNA (circRNA) in acute myeloid leukemia (AML) by using bioinformatics method. Methods: The microarray chip data of AML was searched and downloaded from the Gene Expression Omnibus (GEO) of the National Center for Bioinformatics (NCBI). The differences between AML samples and control…

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Vincerx Pharma Presents Data on PTEFb/CDK9 Inhibitor VIP152 in DLBCL and CLL at the 63rd American Society of Hematology Annual Meeting

VIP152 has increased selectivity and potency compared to other CDK9 inhibitors in development, consistent across DLBCL and CLL models of disease Vincerx hosting KOL webinar today, Saturday, December 11, 2021, at 7:30pm EST PALO ALTO, Calif., Dec. 11, 2021 (GLOBE NEWSWIRE) — Vincerx Pharma, Inc. (Nasdaq: VINC) a biopharmaceutical company…

Continue Reading Vincerx Pharma Presents Data on PTEFb/CDK9 Inhibitor VIP152 in DLBCL and CLL at the 63rd American Society of Hematology Annual Meeting

Mitochondrial DNA-like sequences in the human nuclear genome: Characterization and implications in the evolution of mitochondrial DNA

The complete mitochondrial genome of Flustrellidra hispida (Bryozoa, Ctenostomata, Flustrellidridae) was sequenced using a transposon-mediated approach. All but one of the 36 genes were identified (trnS2). The genome is 13,026 bp long, being one of the smallest metazoan mitochondrial genomes sequenced to date with a unique gene order when compared to…

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Large-scale genome-wide study reveals climate adaptive variability in a cosmopolitan pest

Genomic data The foundational resource for this study was a dataset of 40,107,925 nuclear SNPs sequenced from a worldwide sample of 532 DBM individuals collected in 114 different sites based on our previous project15. DNA was extracted from each of the 532 individuals using DNeasy Blood and Tissue Kit (Qiagen,…

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There are 4 rRNAs produced to make both subunits of the ribosome. How many transcripts are required to produce these 4 rRNAs? a. 1. b. 2. c. 3. d. 4.

Question: There are {eq}4 {/eq} rRNAs produced to make both subunits of the ribosome. How many transcripts are required to produce these {eq}4 {/eq} rRNAs? a. {eq}1 {/eq}. b. {eq}2 {/eq}. c. {eq}3 {/eq}. d. {eq}4 {/eq}. Ribosomes Ribosomes perform the critical action of protein synthesis. Often found in the…

Continue Reading There are 4 rRNAs produced to make both subunits of the ribosome. How many transcripts are required to produce these 4 rRNAs? a. 1. b. 2. c. 3. d. 4.

Prognosis Biomarkers via WGCNA in HCC

Introduction According to the cancer statistics reported in 2020, hepatocellular carcinoma (HCC) is the main type of Primary Carcinoma of the Liver and the second leading causes of cancer-related death globally, with a five-year survival rate < 20%.1 Currently, surgical resection, a standard therapy for HCC, contributes to the prognosis…

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Scientists Discover How mRNA Therapeutics Are Delivered Into Cells

An LNP is located on a long endosomal tubule (green), together with a perpendicular disperse mRNA signal (cyan), and likely representing an instance of mRNA (purple) escape. Credit: Marino Zerial / MPI-CBG Researchers have found where and how mRNA arrives in a cell to modify or deliver genetic information, a…

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Nanotechnology for genome editing in multiple muscles simultaneously

Fig. 1: LNP-mediated Luc-mRNA or CRISPR-Cas9 mRNA/sgRNA delivery into muscle tissue. a Schematic illustration of LNP-CRISPR. Either Luc mRNA or Cas9 mRNA/sgRNA is encapsulated into LNP that consists of TCL053, DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycol-dimyristoyl glycerol), and cholesterol. b Chemical structure of the newly synthesized ionizable lipid, TCL053. c Representative…

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An assessment of pH-sensitive cationic lipid nanoparticles for drug delivery

A recent review in the Chemical and Pharmaceutical Bulletin looks at the molecular design of pH-sensitive cationic lipids and their applications for various tissues and cell types. The researchers also describe the application of lipid nanoparticles (LNPs) for delivering various macromolecules including small interfering ribonucleic acid (siRNA), antisense oligonucleotide, messenger…

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Ethnic Diversity of DPD activity and the DPYD Gene

Plain Language Summary Fluoropyrimidine (FP; 5-FU, capecitabine) is a common chemotherapy used to treat many different cancers, including cancer of the colon and rectum, upper digestive tract, breast and head and neck. Cancer patients who receive FP chemotherapy are at risk of developing severe side effects from their treatment. A…

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Genetic architecture modulates diet-induced hepatic mRNA and miRNA expression profiles in Diversity Outbred mice

Genetic approaches in model organisms have consistently demonstrated that molecular traits such as gene expression are under genetic regulation, similar to clinical traits. The resulting expression quantitative trait loci (eQTL) have revolutionized our understanding of genetic regulation and identified numerous candidate genes for clinically relevant traits. More recently, these analyses…

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Identification of lipid metabolism-associated gene signature

Background Female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer. Despite the dramatic improvement in breast cancer prognosis due to recent therapeutic advances, such as more effective adjuvant and neo-adjuvant chemotherapies, together with more radical and safer surgery, advances in early diagnosis and treatment over the…

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Primer design for variants in duplicated genes?

The issues you face relate to the fact that the majority of the genome exhibits sequence similarity, i.e., similarity with other regions in the genome. Much of this is indeed related to gene duplication events, with the duplicated genes acquiring new functionality over time due to mutations. As a rough…

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The Role Of Process Integration

Article | By Ahmed Besheer, Lonza As the field of biologics increases its focus on identifying new diseases to target and novel constructs to treat them, innovative administration devices are once again in the spotlight. Article | By Bruce C. Simpson, Thermo Fisher Scientific Due to the complexity and temperature sensitivity…

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Figure 5 | TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro

Cysteine depletion induces K562 cell ferroptosis after downregulating TXNRD1. (a, b) qRT-PCR and Western blot analyzed the shRNA-mediated knockdown of TXNRD1 mRNA and protein expression levels in K562 cells. β-Actin mRNA and protein expressions were detected as a loading control for qRT-PCR and Western blot. (c) Cell viability was measured…

Continue Reading Figure 5 | TXNRD1: A Key Regulator Involved in the Ferroptosis of CML Cells Induced by Cysteine Depletion In Vitro

Vincerx Pharma Hosting Key Opinion Leader Webinar on VIP152 Data Presented at the American Society of Hematology Annual Meeting

PALO ALTO, Calif., Dec. 06, 2021 (GLOBE NEWSWIRE) — Vincerx Pharma, Inc. (Nasdaq: VINC), a biopharmaceutical company aspiring to address the unmet medical needs of patients with cancer through paradigm-shifting therapeutics, today announced that it will host a key opinion leader (KOL) webinar to discuss the data presented on the…

Continue Reading Vincerx Pharma Hosting Key Opinion Leader Webinar on VIP152 Data Presented at the American Society of Hematology Annual Meeting

Separation of Rat Epidermis and Dermis with Thermolysin to Detect Site-Specific Inflammatory mRNA and Protein

Presented here is a protocol for the separation of epidermis from dermis to evaluate inflammatory mediator production. Following inflammation, rat hind paw epidermis is separated from the dermis by thermolysin at 4 °C. The epidermis is then used for mRNA analysis by RT-PCR and protein evaluation by western blot and…

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Metagenomics 101 With Spencer Diamond

Jill Banfield and her team have used genome-resolved metagenomics to find new CRISPR systems, huge viruses, whole new branches on the tree of life, and more — but what exactly is metagenomics? We wanted to take a step back and introduce readers to the Banfield lab’s pioneering techniques for finding…

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Escherichia coli K-12 substr. MG1655 tmRNA

Escherichia coli K-12 substr. MG1655 RNA Class: tmRNA Superclasses: a single-stranded RNA Instances: tmRNA Summary: The bacterial tmRNA is so-named for its dual tRNA-like and mRNA-like nature. tmRNA participates in a process mediating recovery from translation problems that result in proteins that are stalled on the ribosome. tmRNA adds a…

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rRNA Function, Location Production & Synthesis | Ribosomal RNA – Video & Lesson Transcript

What is Ribosomal RNA (rRNA)? All proteins made within the body go through the process of DNA transcription and translation. DNA transcription is the process of converting DNA into RNA. During the process of translation, the transcribed RNA is used as a genetic blueprint to convert the information into proteins,…

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How to map query coordinates on to genome gff annoation files ?

How to map query coordinates on to genome gff annoation files ? 0 Hello Researchers I have a project where i got stuck on :- mapping query coordinates on to gff annoation files, means i have to find all the total counts of gene, mRNA, exon, CDS, 3′-utr, 5′-utr, promoter,…

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Identification of circRNA-miRNA-mRNA Regulatory Network and Autophagy Interaction Network in Atrial Fibrillation Based on Bioinformatics Analysis

Background: Circular RNA (circRNA) has been receiving increased attention in the research of atrial fibrillation (AF). Our study aims to find potential circRNAs and identify the circRNA-miRNA-mRNA regulatory network in AF based on bioinformatics analysis. Methods: GSE129409 was retrieved from the Gene Expression Omnibus (GEO) database, and we used R…

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Therapeutic Potential of Exosomal circRNAin RA

Introduction Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial pannus formation resulting from angiogenesis accompanied by inflammation, which leads to cartilage and bone destruction.1 The inflammatory state in RA is maintained by the transport of inflammatory cells and oxygen to the synovium through enhanced angiogenesis. Therefore, angiogenesis…

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TCGA transcriptome data to R (DESeq2)

This seems to be frequently asked question, so here is a robust method to fully recapitulate the counts given by TCGA and port it to DESeq2. Why the long way? Tanya and I noticed via TCGA-Biolinks and Firehose did not generate the full count matrix. ~5-10% of genes were missing…

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A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis

This article was originally published here Bioengineered. 2021 Dec 1. doi: 10.1080/21655979.2021.2012553. Online ahead of print. ABSTRACT The importance of angiogenesis in multiple myeloma (MM) is unquestionable; however, to date, the success of antiangiogenic therapies has been fairly limited. Exosomal circular RNAs (circRNAs) have been proven to be pivotal players…

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Omicron looks ominous. How bad is it likely to be?

Dec 4th 2021 LONDON, MAINZ AND SAN FRANCISCO Listen to this story Your browser does not support the <audio> element. Enjoy more audio and podcasts on iOS or Android. VIROLOGISTS WILL tell you that predicting how a new virus might evolve is a fool’s errand. Predicting that it will evolve,…

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The future of CRISPR is now

It has been more than a year since Markus Mapara, MD, a professor of medicine and director of blood and marrow transplantation at Columbia University Irving Medical Center in New York, first used an experimental CRISPR gene-editing treatment in a patient with sickle cell disease, an inherited blood disorder that…

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Bioinformatics Full Stack Developer – Job Juncture

My pharma client is expanding their group, and seeks a Lab Informatics Developer to provide cutting-edge solutions to an early-stage discovery group that includes mAbs, protein and mRNA therapeutics, and gene therapies.  The ideal candidate will take on the following tasks: Develop a broad array of computational and database tools….

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Omicron drives new urgency for global pandemic treaty

Xavier Becerra, Secretary of Health and Human Services, said failure is not an option in negotiations over an international agreement for pandemic preparedness and response. | Greg Nash, Pool/Getty Images OMICRON SPURS PANDEMIC TREATY URGENCY — The panic Omicron sparked was felt in Geneva, where health officials from around the…

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Potenial biomarker in Crohn’s diease via bioinformatics

Introduction Crohn’s disease (CD) and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract, with symptoms evolving in a relapsing and remitting manner that comprise the term inflammatory bowel disease (IBD).1 CD is characterized by the involvement of all parts of the intestine, the most common being the terminal…

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Genetik Begriffe 16 Flashcards | Quizlet

Genetik Begriffe 16 Flashcards | Quizlet   cleavage and polyadenylation specificity factor, binds AAUAAA cleavage stimulation factor, binds to U-rich sequence, creating a loop -mRNA-some snRNAs-miRNA precursors -5S rRNA-tRNAs-some snRNAs Cleavage requires a large protein complex (4) 1. CPSF2. CstF3. two cleavage factors (CFI, CFII)4. PAP (PolyA polymerase) processing of…

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A Conserved Histophilus somni 23S Intervening Sequence Yields Functional, Fragmented 23S rRNA

All reagents and materials used in this protocol were certified as RNase and DNase free. From the 45-ml culture, 22 ml was placed in a fresh 50-ml conical tube and centrifuged for 3 minutes at 5,000 × g at 4°C to pellet bacteria. The supernatant was decanted, and the pellet was resuspended in…

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Something New to Squeeze Into Your Portfolio

By John Vandermosten, CFA NYSE:SQZ READ THE FULL SQZ RESEARCH REPORT We are initiating coverage of SQZ Biotechnologies Company (NYSE:SQZ) with a current valuation of $30.00 per share. This present value is based on our estimates for a successful development of the Antigen Presenting Cell (APC), Activating Antigen Carrier (AAC)…

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Cellosaurus cell line HEK293T-CAF40-null (CVCL_A5EE)

Cell line name HEK293T-CAF40-null Synonyms CAF40-null HEK293T Accession CVCL_A5EE Resource Identification Initiative To cite this cell line use: HEK293T-CAF40-null (RRID:CVCL_A5EE) Comments Doubling time: ~30-40 hours (DSMZ).Knockout cell: Method=CRISPR/Cas9; HGNC; 10445; CNOT9.Transfected with: UniProtKB; P00552; Transposon Tn5 neo.Transformant: NCBI_TaxID; 28285; Adenovirus 5.Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [tsA].Derived from sampling…

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Help with TCPA Protein Names

Help with TCPA Protein Names 0 Hello everyone, I would want to correlate protein expression and mRNA expression in my breast cancer research. I downloaded L4 level RPPA data from the TCPA portal: tcpaportal.org/tcpa/download.html, and got a protein expression matrix which is great. However, I was baffled by the protein…

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Frontiers | Plasma Cell-Free DNA Methylomics of Bipolar Disorder With and Without Rapid Cycling

Introduction Bipolar disorder (BD) features recurrent episodes of mania/hypomania and depression, interspersed with periods of euthymia. Symptoms usually include drastic changes in energy levels, sleep, thinking, and behaviors, which can significantly disrupt the daily life of BD patients (Craddock and Sklar, 2013). A mood cycle is defined as the period…

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The Role of DNA Methylation in Human Disease

DNA methylation is one of the earliest epigenetic modifications to be discovered in human beings. It involves the transfer of methyl (CH3) groups to the C5 position of cytosine bases that comprise deoxyribonucleic acid (DNA) to produce 5-methylcytosine (5mC) – the reaction is catalyzed by a family of enzymes called…

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The Construction and Comprehensive Analysis of a ceRNA Immunoregulator

1Department of Cardiology, Xiangtan Central Hospital, Xiangtan, Hunan, People’s Republic of China; 2Department of Cardiology, Guangxi Cardiovascular Institute, The First Affiliated Hospital of Guangxi Medical University, Guangxi, People’s Republic of China; 3Department of Critical Care Medicine, Zhuzhou Central Hospital, Zhuzhou, Hunan, People’s Republic of China Correspondence: Yiqian ZengDepartment of Critical…

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Comprehensive analysis of ceRNA networks to determine genes related to prognosis, overall survival, and immune infiltration in clear cell renal carcinoma

Comput Biol Med. 2021 Nov 20:105043. doi: 10.1016/j.compbiomed.2021.105043. Online ahead of print. ABSTRACT BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is one of the common subtypes of kidney cancer. Circular RNAs (circRNAs) act as competing endogenous RNAs (ceRNAs) to affect the expression of microRNAs (miRNAs), and hence the expression of…

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De novo assembly of mRNA-seq has many transcripts binding to introns or genome parts (not protein coding genes)

Hi all, For the first time, I am working on some de novo mRNAseq data already analyzed by a company (the same that perfomed the sequencing). The samples are from a species for which we don’t have an annotated genome. They assembled the transcriptome with trinity (which resulted in more…

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Table1_Identification of Potential circRNA-microRNA-mRNA Regulatory Network in Skeletal Muscle.XLSX

Circular RNAs (circRNAs) are a newly discovered family of regulatory RNAs generated through backsplicing. Genome-wide profiling of circRNAs found that circRNAs are ubiquitously expressed and regulate gene expression by acting as a sponge for RNA-binding proteins (RBPs) and microRNAs (miRNAs). To identify circRNAs expressed in mouse skeletal muscle, we performed…

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pearson correlation between lncRNA and mRNA

pearson correlation between lncRNA and mRNA 1 Hi, I have 2 different normalised DEGs data set and I am trying to determine pearson correlation between these lncRNA and mRNA data sets. I tried cor.test function in R but it reads gene list at first column and I am taking “x…

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Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance

1 Introduction Lung cancer is the leading cause of cancer-related deaths worldwide, with adenocarcinoma as the most common histological subtype.1 In recent years, epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib (first generation) and osimertinib (third generation), have been widely used for lung adenocarcinoma patients harboring activated EGFR…

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Discovering a new gene in monkeys that could help in the development of new antivirals

In this interview, we spoke with Dr. Nels Elde about his latest research that led to the discovery of a new gene in monkeys that could help in the development of new antivirals. What prompted your latest research on antivirals? We wonder if a cellular process exploited by viruses, including…

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Finding a new gene in monkeys that could help develop new antiviral drugs

In this interview, we spoke with Dr. Nels Elde about his latest study, which led to the discovery of a new gene in monkeys that could help develop new antiviral drugs. What got your latest study on antiviral drugs? We were curious whether the cellular process utilized by viruses, including…

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Discovering a new gene in monkeys that could help develop new antivirals

In this interview, we spoke to Dr Nels Elde about his latest research which led to the discovery of a new gene in monkeys that could help develop new antivirals. What prompted your latest research on antivirals? We were curious to know if a cellular process exploited by viruses, including…

Continue Reading Discovering a new gene in monkeys that could help develop new antivirals

Discovering a new gene in monkeys that could help to develop new antivirals

In this interview, we spoke to Dr. Nels Elde about his latest research that led to the discovery of a new gene in monkeys that could help to develop new antivirals. What provoked your latest research into antivirals? We were curious if a cellular process exploited by viruses, including HIV,…

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A new monkey gene has been identified that could lead to creation of new antivirals

In this interview, we talked to Dr. Nels Elde about his recent research that led to the discovery of a novel gene in monkeys, which could help to develop new antivirals. What was the inspiration behind your latest research into antivirals We were interested to see if a cellular process…

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Immune cell – ANGPTL8 – The Human Protein Atlas

ANDNOT FieldAllGene nameProtein classUniprot keywordChromosomeExternal idTissue expression (IHC)Patient ID (IHC)Tissue category (RNA)Tissue expression cluster (RNA)Reliability score tissue (IHC)Brain region category (RNA)Mouse brain category (RNA)Pig brain category (RNA)Reliability score mouse brainCell type category (RNA)Single cell type expression cluster (RNA)Cell type enrichment (RNA)Prognostic cancerCancer category (RNA)Immune cell category (RNA)Immune cell lineage category…

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RNAseq analysis of treatment-dependent signaling changes during inflammation in a mouse cutaneous wound healing model

Background: Despite proven therapeutic effects in inflammatory conditions, the specific mechanisms of phytochemical therapies are not well understood. The transcriptome effects of Traumeel (Tr14), a multicomponent natural product, and diclofenac, a non-selective cyclooxygenase (COX) inhibitor, were compared in a mouse cutaneous wound healing model to identify both known and novel…

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High-Throughput RNA Sequencing Reveals the Effect of NB-UVB

Introduction Psoriasis vulgaris, major chronic immune-mediated skin disease, affects 1–3% of the adult population worldwide.1 Psoriasis is one of the major complex skin diseases that is significantly linked to genetic predisposition, major histocompatibility alleles, and environmental factors.2 Over the past few years, the cellular and molecular contributions to psoriasis were…

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Immune cell – EPCAM – The Human Protein Atlas

ANDNOT FieldAllGene nameProtein classUniprot keywordChromosomeExternal idTissue expression (IHC)Patient ID (IHC)Tissue category (RNA)Tissue expression cluster (RNA)Reliability score tissue (IHC)Brain region category (RNA)Mouse brain category (RNA)Pig brain category (RNA)Reliability score mouse brainCell type category (RNA)Single cell type expression cluster (RNA)Cell type enrichment (RNA)Prognostic cancerCancer category (RNA)Immune cell category (RNA)Immune cell lineage category…

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