Tag: MRSA

Which region of the rRNA is used for synethsizing primers for species identification?5 answersThe region of the rRNA used for synthesizing primers for species identification is the mitochondrial 12S rRNA gene. This gene segment is commonly targeted in PCR-based methods for species identification and taxonomic classification. It has been used…

Commission, S. P. Pharmacopoeia of the People’s Republic of China (Pharmacopoeia of the People’s Republic of China, 2020). Google Scholar  Sun, X. & Sun, F. Shennong Materia Medica Classic (People’s Health Publishing House, 1963). Google Scholar  Huang, C. Flora of China Vol. 43 (Science Press, 1997). Google Scholar  Hu, J….

Our NAS collection comprised over 30 species of Staphyloccocus, including at least 10 isolates of S. epidermidis, S. capitis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans and S. warneri (Table 1). Isolates were collected over a 4-year period from 2013 to 2016. Table 1 Frequency of non-aureus staphylococcal speciesa…

Introduction Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in 2019, this coronavirus has spread to more than 200 countries, cumulatively infecting 672 million people and causing 6.84 million deaths. Moreover, the emergence of numerous variant strains (α, β, γ, δ, and Omicron) presents a serious challenge for…

Bond, R. & Loeffler, A. What’s happened to Staphylococcus intermedius? Taxonomic revision and emergence of multi-drug resistance. J. Small Anim. Pr. 53, 147–154 (2012). Article  CAS  Google Scholar  Carroll, K. C., Burnham, C. D. & Westblade, L. F. From canines to humans: clinical importance of Staphylococcus pseudintermedius. PLoS Pathog. 17,…

The healthcare and genetics industries have seen a major shift because to the DNA diagnostics market, which has completely changed how we identify, treat, and comprehend a wide range of illnesses and ailments. With the development of technology and our understanding of genetics, this quickly expanding industry has expanded to…

What You Should Know The FDA’s acceptance of the New Drug Application (NDA) for ceftobiprole, submitted in August, could signifies a significant step forward in addressing severe bacterial infections. Ceftobiprole was designated as a candidate for the US Generate Antibiotics Incentives Now (GAIN) Act, which facilitates the development of new…

In a recent study published in Microbial Genomics, researchers investigated the genomes of a group of Staphylococcus capitis isolates from neonates. Study: Characterisation of neonatal Staphylococcus capitis NRCS-A isolates compared with non NRCS-A Staphylococcus capitis from neonates and adults. Image Credit: Dmitry Kalinovsky/Shutterstock.com Background NRCS-A, a clone of S. capitis,…

The Food and Drug Administration (FDA) has accepted the New Drug Application for ceftobiprole, an investigational, broad spectrum cephalosporin antibiotic for intravenous administration. Basilea is seeking approval for 3 indications: Staphylococcus aureus bacteremia (SAB), including right-sided infective endocarditis, acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneumonia…

Seeking approval for Staphylococcus aureus bacteremia (SAB), acute bacterial skin and skin structure infections (ABSSSI), and community-acquired bacterial pneumonia (CABP) Prescription Drug User Fee Act (PDUFA) goal date set for April 03, 2024 Ad hoc announcement pursuant to Art. 53 LR Allschwil, Switzerland, October 02, 2023 Basilea Pharmaceutica Ltd, Allschwil…

Introduction The coronavirus disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continues to threaten human life worldwide. The disease severity of COVID-19 patients is very wide: from an asymptomatic carrier state to severe infection and critical illness with intensive care admission and/or mechanical…

Allschwil, Switzerland, September 28, 2023 Basilea Pharmaceutica Ltd, Allschwil (SIX: BSLN), a commercial-stage biopharmaceutical company committed to meeting the needs of patients with severe bacterial and fungal infections, announced today that data from the successful phase 3 study ERADICATE were published in the New England Journal of Medicine (NEJM), one…

Allschwil, Switzerland, September 28, 2023 Basilea Pharmaceutica Ltd, Allschwil (SIX: BSLN), a commercial-stage biopharmaceutical company committed to meeting the needs of patients with severe bacterial and fungal infections, announced today that data from the successful phase 3 study ERADICATE were published in the New England Journal of Medicine (NEJM), one…

Destiny Pharma plc (“Destiny Pharma” or the “Company”)   Interim results for the six months ended 30 June 2023   Active discussions with potential partners for XF-73 nasal supported by new market analysis that underscores $2bn market opportunity   Partnering deal with Sebela Pharmaceuticals for NTCD-M3 in North America fully…

Guh, A. Y. et al. Trends in U.S. Burden of Clostridioides difficile infection and outcomes. N. Engl. J. Med. 382, 1320–1330 (2020). Article  CAS  PubMed  PubMed Central  Google Scholar  Antibiotic Resistance Threats in the United States (Centers for Disease Control and Prevention, 2019); doi.org/10.15620/cdc:82532 Evans, C. T. & Safdar, N….

The present protocol prepares and evaluates the physical properties, immune response, and in vivo protective effect of a novel nanoemulsion adjuvant vaccine. The demonstrated protocol underlined the direct and effective experimental approach and the detailed steps to immune response effects of novel viral adjuvants. This protocol provides the research with…

At present, methicillin-resistant Staphylococcus aureus (MRSA) has caused a serious impact on a global scale. The infection and carrier rate of MRSA in the community is increasing year by year, but there is still no convenient detection system for on-site rapid detection. It is very important to select a rapid…

Dadgostar, P. Antimicrobial resistance: Implications and costs. Infect. Drug Resistance 12, 3903–3910 (2019). Article  CAS  Google Scholar  Rosenblatt-Farrell, N. The landscape of antibiotic resistance. Environ. Health Perspect. 117, A244–A250 (2009). Article  PubMed  PubMed Central  Google Scholar  Roberts, S. C. & Zembower, T. R. Global increases in antibiotic consumption: a concerning…

Wu, Z. Antibiotic Use and Antibiotic Resistance in Food-Producing Animals in China OECD Food, Agriculture and Fisheries Paper No. 134 (OECD, 2019); doi.org/10.1787/4adba8c1-en Looft, T. et al. In-feed antibiotic effects on the swine intestinal microbiome. Proc. Natl Acad. Sci. USA 109, 1691–1696 (2012). Article  ADS  CAS  PubMed  PubMed Central  Google…

1. Introduction S. aureus is the leading cause of nosocomial infections worldwide [1]. Although it is a normal resident of the skin and mucous membranes of humans and animals, S. aureus can become an opportunistic pathogen by deploying a plethora of virulence factors to cause a variety of infections, ranging…

(MENAFN– Straits Research) Real-time PCR, or quantitative PCR, is an established method for sensitive and rapid nucleic acid quantification in various biological samples. Real-time PCR, or quantitative PCR, is an established method for sensitive and rapid nucleic acid quantification in various biological samples. Endpoint PCR, also known as conventional PCR,…

Seeking approval for Staphylococcus aureus bacteremia (SAB), acute bacterial skin and skin structure infections (ABSSSI), and community-acquired bacterial pneumonia (CABP) NDA eligible for Priority Review Ad hoc announcement pursuant to Art. 53 LR Allschwil, Switzerland, August 04, 2023 Basilea Pharmaceutica Ltd, Allschwil (SIX: BSLN), a commercial-stage biopharmaceutical…

The New Drug Application (NDA) for ceftobiprole medocaril (ceftobiprole) has been submitted for review to the Food and Drug Administration (FDA) by Basilea. Ceftobiprole is a cephalosporin antibiotic for intravenous administration with rapid bactericidal activity against a wide range of Gram positive bacteria such as Staphylococcus aureus, including methicillin-resistant strains…

1. Introduction Staphylococcus aureus is an important pathogen in healthcare and community settings that can cause a broad spectrum of diseases, ranging from skin and soft-tissue infections to invasive diseases such as pneumonia, septicemia, and endocarditis [1]. In the 1960s [2], soon after the introduction of methicillin into the healthcare…

Principle of CPA-Cas 12a lateral flow assay strategy CPA and CPA-Cas 12a sensing strategies were proposed for detection of nuc and mecA genes in MRSA respectively. According to the sequence of the target gene, we designed two PAM sites and four pairs of primer according to the principles of double-crossing…

. 2023 Jul 11;265:124931. doi: 10.1016/j.talanta.2023.124931. Online ahead of print. Affiliations Expand Affiliations 1 State Key Laboratory of Marine Resource Utilization in South China Sea, Marine College, Hainan University, Haikou 570228, China. 2 Agriculture and Agri-Food Canada, Fredericton, New Brunswick, E3B 4Z7, Canada; Nutra Health Products and Technologies Inc., Fredericton…

LOS GATOS, Calif., July 17, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced positive feedback from the European Medicines Agency (EMA) on the Company’s proposed single confirmatory Phase 3 study of investigational monoclonal antibody candidate AR-301, which is being developed as an adjunctive therapy in combination with…

The protocols provide a method to examine the antimicrobial activities of nanoparticle and nanostructured surfaces from preliminary stage investigations to more complex surface examinations. Unlike previously described methods that resulted in incomparable data across studies, these methods produce consistent and comparable results across different nanoparticle materials, nanostructured materials, and microbial…

Molecular Diagnostics Market The global Molecular Diagnostics Market Size was valued at US$ 38 Billion in 2022 and is projected to reach US$ 59.4Billion by 2033, at a CAGR of 4.3%. The global molecular diagnostics market has been experiencing significant growth in recent years. Factors driving market growth include the…

By Laura Powell, Managing Consultant and Steve Morris, Managing Director CHARLESTON, S.C., June 28, 2023 /PRNewswire/ — The National Institute of Allergy and Infectious Diseases (NIAID) recently released a Notice of Special Interest (NOSI) aimed at encouraging research proposals on targeted protein and nonprotein degradation for the development of anti-infective…

Materials The lipid cetyl palmitate was a kind gift from Gattefossé (Gattefossé SAS, Saint-Priest, France). DSPE-PEG2000-NH2 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (ammonium salt)) was purchased from Avanti Polar Lipids Inc. (Alabaster, Alabama, USA). D-Phenylalanine, D-Proline, D-Tyrosine, triethylamine (TEA), dicyclohexylcarbodiimide (DCC), N-hydroxysuccinimide (NHS), sodium hydroxide (NaOH), sodium chloride, moxifloxacin hydrochloride (MOX), farnesol 95%, Tween®80,…

LOS GATOS, Calif., June 08, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS), a biopharmaceutical company focused on the discovery and development of novel anti-infective therapies for treating life-threatening infections, today reported financial and corporate results for its first quarter ended March 31, 2023. First Quarter & Subsequent Highlights Met…

What is Next-Generation Sequencing (NGS)? Next-Generation Sequencing (NGS), also known as high-throughput sequencing, has revolutionized the field of genomics and molecular biology by allowing the sequencing of thousands to millions of DNA molecules simultaneously. It encompasses a range of different sequencing technologies, all aimed at producing large amounts of sequence…

Wanyang Dong,1,* Qi Peng,1,* Xiaohua Tang,1,2,* Tian Zhong,1 Shunan Lin,1 Ziling Zhi,1 Jingyi Ye,1 Bixia Yang,1 Ning Sun,1,3 Wenchang Yuan1 1Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, 510180, People’s Republic of China; 2Third Affiliated Hospital…

Identifying whether and how a nanoparticle and protein will bind with one another is an important step toward being able to design antibiotics and antivirals on demand, and a computer model developed at the University of Michigan can do it. The new tool could help find ways to stop antibiotic-resistant…

The new computer model, NeCLAS, predicts that a nanoparticle, shown as a set of yellow balls attached by netting, fits neatly around a very specific protrusion on a protein, marked in blue. The binding site is confirmed by experiments. These kinds of nanoparticles, called molecular tweezers, can be used to…

LOS GATOS, Calif., May 31, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced positive feedback from the FDA on the Company’s proposed single confirmatory Phase 3 study of investigational monoclonal antibody candidate AR-301, which is being developed as an adjunctive therapy in combination with standard of care…

LOS GATOS, Calif., May 31, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced positive feedback from the FDA on the Company’s proposed single confirmatory Phase 3 study of investigational monoclonal antibody candidate AR-301, which is being developed as an adjunctive therapy in combination with standard of care…

Inexpensive in vitro Methods to Evaluate the Impact of Cannabinoid-containing Products on Sentinel Lactobacillus spp.  S. Lewin 1, A. Hilyard2, H. Piscatelli1, A. Hangman1, D. Petrik1, P. Miles2, and C. Orser2 1MatMaCorp Inc, Lincoln NE; 2Apothercare LLC, Boston MA  Abstract The public has readily embraced cannabidiol (CBD) in countless unregulated products…

The Point-Of-Care Molecular Diagnostics Market is predicted to secure a valuation of US$ 4.4 billion in 2023 and is rising to US$ 11.1 billion by 2033. The market is estimated at a CAGR of 9.7% during the forecast period. Rising infectious and chronic diseases, such as cardiovascular, diabetes, and COVID-19, are increasing…

Introduction Severe hospital-acquired pneumonia (SHAP) is the most common acquired infection in the intensive care unit (ICU) and one of the main causes of increased mortality in ICU patients.1,2 Potential multidrug-resistant pathogens are very common in ICU-acquired pneumonia, including Pseudomonas aeruginosa, Acinetobacter spp., methicillin-resistant Staphylococcus aureus (MRSA), and ultrabroad spectrum…

NEW YORK – Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) (‘Aptorum Group‘ or ‘Company’), today announced that its wholly owned subsidiary Aptorum Therapeutics Limited (‘ATL’) has entered into a non-binding Letter of Intent and Term Sheet to merge its 100% subsidiary, Paths Innovation Limited and its underlying business with…

NEW YORK & LONDON & PARIS, May 01, 2023–(BUSINESS WIRE)–Regulatory News: Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) (“Aptorum Group” or “Company”), today announced that its wholly owned subsidiary Aptorum Therapeutics Limited (“ATL”) has entered into a non-binding Letter of Intent and Term Sheet (“Term Sheet”) to merge (“Transaction”)…

Iya Agha from Paradise Valley was among the New York Institute of Technology students who showcased their scholarly work at the annual Symposium of University Research and Creative Expression on April 14. At the institute’s New York City campus, 119 student research projects were shared in the form of oral…

Bangalore, also known as Bengaluru, is widely recognized as India’s leading biotech hub, with some of the largest biotech companies in the country based in the city. In this article, we take a look at five biotechs to come out of Bangalore.  Home to the Centre for Cellular and Molecular…

Pictured: Students Emaan Naeem Mughal, left, and Puneet Dhaliwal present their academic research poster, “The Effect of Brain Dehydration on the Efficacy of Cerebrospinal Fluid’s Cushioning Effect: A Computational Study.” One hundred twenty three abstracts were accepted for oral or poster presentations at this year’s Symposium of University Research and…

Introduction Increasing antibiotic resistance is a worrisome trend being observed worldwide. Methicillin-resistant Staphylococcus aureus (MRSA) was first reported in the United Kingdom (UK) in 1961 and has since been reported throughout the world as a nosocomial pathogen.1 A steady increase in the occurrence of MRSA strains has been reported in…

​​​​​​​In a recent study published in the Nutrients journal, researchers in the United States investigated the association between caffeine, coffee consumption, and the colonic microbiome. ​​​​​​​ Study: The Association between Caffeine Intake and the Colonic Mucosa-Associated Gut Microbiota in Humans—A Preliminary Investigation. Image Credit:Rawpixel.com/Shutterstock.com Background Caffeine has been extensively consumed in…

The discovery of penicillin in 1928 by Alexander Fleming was a momentous moment in the world of healthcare, eventually leading to the development of antibiotic drugs that allowed physicians to treat illnesses and infections that were once severe and life-threatening. But our reliance on antibiotics has now led to an…

Introduction Bacteriophage (phage) is a class of widespread viruses exclusively infecting bacteria, playing a key role in ecosystems.1–3 Since phages were discovered over a hundred years ago, many techniques and reagents, such as DNA polymerase, restriction endonuclease, ligase, and CRISPR/Cas system, have been developed from phages, which have together accelerated…

World Health Organization (2020) Lack of new antibiotics threatens global efforts to contain drug-resistant infections. World Health Organization, New release Geneva Google Scholar  Kmietowicz Z (2017) Few novel antibiotics in the pipeline, WHO warns. BMJ: British Medical Journal (Online) 358:1. doi.org/10.1136/bmj.j4339 Article  Google Scholar  Falagas ME, Lourida P, Poulikakos P,…

A three-component protocol was established to efficiently synthesize (chromene-thiazole) and related arylazo analogs in good to excellent yields. The desired products were prepared by reacting the appropriate salicylaldehydes, 2-cyanothioacetamide, and chloroacetone or hydrazonyl chlorides. Using piperidine as a mediator in ethanol at 80 °C for 4-6 h, the three-component protocol…

In order to ensure the prevention and control of methicillin-resistant Staphylococcus aureus (MRSA) infection, rapid and accurate detection of pathogens and their resistance phenotypes is a must. Therefore, this study aimed to develop a fast and precise nucleic acid detection platform for identifying S. aureus and MRSA. We initially constructed…

This week our guests are Marit Inngjerdingen from the Institute of Clinical Medicine in Norway; Kyle Forcier, senior director of life sciences product marketing at Model N; and Dr. Andreas Roetzer, head of R&D for vaccines at Biomedical Research & Bio-Products. The next breakthrough in cancer treatment? In our body,…

Introduction Staphylococcus aureus (S. aureus), a major human opportunistic pathogen, can cause a variety of infectious diseases including skin and soft-tissue infections, bacteremia, ventilator-associated pneumonia and toxic shock syndrome.1,2 A rapid and proper administration of antibiotics is the most important means to inhibit S. aureus’ growth and prevent disease progression….

The first vaccine to potentially prevent Staphylococcal-induced toxic shock syndrome (TSS) has successfully completed a phase 2 study. TSS is a life-threatening condition caused by toxins that can lead to multiple organ failure and death. Nosocomial pathogen methicillin-resistant Staphylococcus aureus (MRSA) bacteria are resistant to widely-used antibiotics. Infections with MRSA…

Model of Rep-mediated SaPI DNA initiation of replication. (A) The ATP-independent flexibility of CTD exposes the residues involved in iteron recognition. The diameter of the barrel in its N and C terminal sides might accommodate dsDNA. In (B), two hexamers have been speculatively depicted embracing dsDNA. Potential hexamer-hexamer interactions might…

The stock price of Aridis Pharmaceuticals (ARDS) fell by 34.96% today. This is why. The stock price of Aridis Pharmaceuticals (ARDS) fell by 34.96% today. This is why. Why: Aridis Pharmaceuticals announced top-line results from the AR-301-002 Phase 3 study, which evaluated the superiority of adjunctive use of the investigational…

gorodenkoff Aridis Pharmaceuticals (NASDAQ:ARDS) monoclonal antibody therapy AR-301 failed the main goal in a phase 3 trial to treat Ventilator Associated Pneumonia (VAP) caused by Gram-positive bacteria Staphylococcus aureus (S. aureus). The study, dubbed AR-301-002, evaluated the superiority of adjunctive use of AR-301 with standard of care (SOC) antibiotics versus…

Aridis Pharmaceuticals, Inc. LOS GATOS, Calif, Jan. 25, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced top-line results from the AR-301-002 Phase 3 study, which evaluated the superiority of adjunctive use of the investigational monoclonal antibody candidate AR-301 with standard of care (SOC) antibiotics versus SOC antibiotics…

Get inside Wall Street with StreetInsider Premium. Claim your 1-week free trial here. (Updated – January 25, 2023 4:28 PM EST) Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced top-line results from the AR-301-002 Phase 3 study, which evaluated the superiority of adjunctive use of the investigational monoclonal antibody candidate AR-301…

Destiny Pharma (DEST Follow | DEST), a clinical stage biotechnology company, issued a note detailing an increased focus on infection prevention by the US CDC and FDA regulators as well as the medical community at large, following recent announcements and publications in leading medical journals. Destiny released the note as context for…

LOS GATOS, Calif, Jan. 25, 2023 (GLOBE NEWSWIRE) — Aridis Pharmaceuticals, Inc. (Nasdaq: ARDS) today announced top-line results from the AR-301-002 Phase 3 study, which evaluated the superiority of adjunctive use of the investigational monoclonal antibody candidate AR-301 with standard of care (SOC) antibiotics versus SOC antibiotics alone, for the…

doi: 10.1016/j.bios.2022.114984. Online ahead of print. Affiliations Expand Affiliations 1 College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. Electronic address: wly2025@163.com. 2 College of Food Science and Technology, Huazhong Agricultural University, Wuhan, 430070, Hubei, China. Electronic address: wzl186@webmail.hzau.edu.cn. 3 School of Food Science and Engineering,…

Cui, B., Smooker, P. M., Rouch, D. A., Daley, A. J. & Deighton, M. A. Differences between two clinical Staphylococcus capitis subspecies as revealed by biofilm, antibiotic resistance, and pulsed-field gel electrophoresis profiling. J. Clin. Microbiol. 51, 9–14 (2013). CAS  PubMed  PubMed Central  Article  Google Scholar  Tevell, S., Hellmark, B.,…

Introduction Aural infections are one of the most common diseases of the head and neck and are predominantly caused by bacterial infections of the ear canal. Several studies from different countries have reported that Pseudomonas aeruginosa is the most common pathogen isolated from ear canal secretions, followed by Staphylococcus aureus.1…

hisat2 alignment showing 0% aligned but sam file is 6GB in size. 0 Hello, I am trying to align my fastq files with the reference genome assembly (MRSA ATCC 33591). The sam file formed is some 5-6 GB in size whereas hisat2 output is showing 0.0% alignment rate. I am…

How to align fastq files against a reference assembly 0 Hello, I am trying to align fastq files against the bacterial MRSA ATCC 33591 reference genome. The problem I am facing is that I have the reference assembly in fasta format with multiple sequences and upon creating index with hisat2-build…