Tag: mtDNA

A ‘De-Extinction’ Company Wants to Bring Back the Dodo

Colossal Biosciences, the headline-grabbing, venture-capital-funded juggernaut of de-extinction science, announced plans on January 31 to bring back the dodo. Whether “bringing back” a semblance of the extinct flightless bird is feasible is a matter of debate. Founded in 2021 by tech entrepreneur Ben Lamm and Harvard University geneticist George Church,…

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Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep | BMC Genomics

Zhao E, Yu Q, Zhang N, Kong D, Zhao Y. Mitochondrial DNA diversity and the origin of Chinese indigenous sheep. Trop Anim Health Prod. 2013;45(8):1715-22. Liu J, Ding X, Zeng Y, Yue Y, Guo X, Guo T, et al. Genetic diversity and phylogenetic evolution of Tibetan sheep based on mtDNA D-loop…

Continue Reading Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Panou Tibetan sheep | BMC Genomics

Inferring genetic structure when there is little: population genetics versus genomics of the threatened bat Miniopterus schreibersii across Europe

Charlesworth, B. & Charlesworth, D. Population genetics from 1966 to 2016. Heredity 118, 2–9 (2017). CAS  Google Scholar  Orsini, L., Vanoverbeke, J., Swillen, I., Mergeay, J. & Meester, L. Drivers of population genetic differentiation in the wild: Isolation by dispersal limitation, isolation by adaptation and isolation by colonization. Mol. Ecol….

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Potential Roles of mtDNA Mutations in PCOS-IR

Introduction Polycystic ovary syndrome (PCOS) is the most common endocrine disease occurring during reproductive years. It was a kind of endocrine and metabolic disorders that results in obesity, irregularity of menstruation, OS, hyperinsulinemia, hyperandrogenism, infertility, and sterility.1,2 First identified in 1935, PCOS was also recognized as Stein–Leventhal syndrome.3 Diagnosis of…

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Leukocyte Telomere Length Predicts Severe Disability in Relapsing-Remitting Multiple Sclerosis and Correlates with Mitochondrial DNA Copy Number

Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease that affects the nervous system. Peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN) are potential biomarkers of neurological disability and neural damage. Our objective was to assess the LTL and mtDNA-CN in relapsing-remitting MS (RRMS). We included…

Continue Reading Leukocyte Telomere Length Predicts Severe Disability in Relapsing-Remitting Multiple Sclerosis and Correlates with Mitochondrial DNA Copy Number

Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson’s disease

Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease-modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggregated form, which accumulates in the brain of PD patients as Lewy bodies. While it…

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Solved Question 72 Not yet saved Marked out of 1.00 Flag

Question 72 Not yet saved Marked out of 1.00 Flag question Question text The mitochondrial DNA (mtDNA) is a useful part of the cell for paleoanthropological research, especially examination of the so-called ‘molecular clock,’ because mtDNA: Select one: a. Is passed through the maternal line (not subject to recombination) and…

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When men are in charge they at least ‘try” to set rules that encourage a functional society – evolution shaped men such that they fear a dysfunctional society means death. Women lack that fear and make no such effort – they just indulge their impulses. The most important chart Covfefe Anon R to @CovfefeAnon Y chromosomes are passed on purely on the male line, mtDNA purely on the female line. Massive pinch in the surviving Y chromosome lines when mtDNA lines never went extinct. If you society fails and you’re a man, your line dies out – women just find new husbands. 3 424 I Covfefe Anon Anon The result is that there’s been no society that let women have a voice in running things “because they have no skin in the game”. It’s totally unsurprising that women come up with unnatural and bizarre rules that create non-functional societies. On

When men are in charge they at least ‘try” to set rules that encourage a functional society – evolution shaped men such that they fear a dysfunctional society means death. Women lack that fear and make no such effort – they just indulge their impulses. The most important chart Covfefe…

Continue Reading When men are in charge they at least ‘try” to set rules that encourage a functional society – evolution shaped men such that they fear a dysfunctional society means death. Women lack that fear and make no such effort – they just indulge their impulses. The most important chart Covfefe Anon R to @CovfefeAnon Y chromosomes are passed on purely on the male line, mtDNA purely on the female line. Massive pinch in the surviving Y chromosome lines when mtDNA lines never went extinct. If you society fails and you’re a man, your line dies out – women just find new husbands. 3 424 I Covfefe Anon Anon The result is that there’s been no society that let women have a voice in running things “because they have no skin in the game”. It’s totally unsurprising that women come up with unnatural and bizarre rules that create non-functional societies. On

Ceebta aduunka :O We need to have an emergency talk on Somali incels. Because wtf is this? | Page 3 | Somali Spot

Also, further reading for those who are interested in Somali MTDNA (Maternal lineage) Someone compiled this in 2021 of 284 Somalis they are connected to, most Somalis are from the Mitochondrial Eve MTDNA line (L). These awful losers, are insulting our ancestral mothers, Ilaahay ha uu naxariisto dhamaantood. It doesn’t…

Continue Reading Ceebta aduunka :O We need to have an emergency talk on Somali incels. Because wtf is this? | Page 3 | Somali Spot

The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice | Cell Communication and Signaling

Malhi GS, Mann JJ. Depression. Lancet. 2018;392:2299–312. Article  Google Scholar  Wang B, Zhang H, Cao X. Research progress of non-monoamine antidepressants. Stress Brain. 2021;1:128–44. Article  Google Scholar  Coccaro EF. New hope for patients with major depressive disorder? N Engl J Med. 2019;381:980–1. Article  Google Scholar  Cai N, Chang S, Li…

Continue Reading The mitochondrial Ahi1/GR participates the regulation on mtDNA copy numbers and brain ATP levels and modulates depressive behaviors in mice | Cell Communication and Signaling

Endosomal-dependent mitophagy coordinates mitochondrial nucleoid and mtDNA elimination

doi: 10.1080/15548627.2023.2170959. Online ahead of print. Affiliations Expand Affiliations 1 Center for Physiology and Pathophysiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. 2 Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. Item in Clipboard Ayesha Sen et al. Autophagy. 2023. Show details Display options…

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Reduced mitochondrial DNA content correlate with poor clinical outcomes in cryotransfers with day 6 single euploid embryos

Objective: To investigate whether the mitochondrial DNA (mtDNA) content of a single biopsy at trophoblast correlates with the developmental potential and reproductive outcomes of blastocyst. Methods: A retrospective analysis applied the dataset of 1,675 embryos with preimplantation genetic testing for aneuploidy (PGT-A) from 1,305 individuals, and 1,383 embryos involved cryotransfers…

Continue Reading Reduced mitochondrial DNA content correlate with poor clinical outcomes in cryotransfers with day 6 single euploid embryos

The metazoan landscape of mitochondrial DNA gene order and content is shaped by selection and affects mitochondrial transcription

Boore, J. L. Animal mitochondrial genomes. Nucleic Acids Res. 27, 1767–1780 (1999). Article  CAS  Google Scholar  Calvo, S. E., Clauser, K. R. & Mootha, V. K. MitoCarta2. 0: an updated inventory of mammalian mitochondrial proteins. Nucleic Acids Res. 44, D1251–D1257 (2016). Article  CAS  Google Scholar  Andrews, R. M. et al….

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MtDNA Variation And Evaluation Of Phylogenetic Relationships Among Karyotypically Polymorphic Populations Of Microtus (Terricola) Thomasi (Arvicolidae, Rodentia) From Greece

The Balkan endemic species Microtus (Terricola) thomasi – Thomas’ vole – is widely distributed in the Greek mainland and presents regionally confined karyotypic forms. In order to test the significance of geographical isolation and/or karyological differences in microevolutionary processes at the intraspecific level we used restriction enzymes and partial…

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Phylogeny and Genetic Diversity of Philippine Native Pigs (Sus scrofa) as Revealed by Mitochondrial DNA Analysis

Ai H, Fang X, Yang B, Huang Z, Chen H, Mao L, Zhang F, Zhang L, Cui L, He W, Yang J, Yao X, Zhou L, Han L, Li J, Sun S, Xie X, Lai B, Su Y, Lu Y, Yang H, Huang T, Deng W, Nielsen R, Ren J,…

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Evaluation of automated techniques for extraction of circulating cell-free DNA for implementation in standardized high-throughput workflows

Huebner, H. et al. Filtration based assessment of CTCs and Cell Search® based assessment are both powerful predictors of prognosis for metastatic breast cancer patients. BMC Cancer 18, 204. doi.org/10.1186/s12885-018-4115-1 (2018). Article  Google Scholar  Banys-Paluchowski, M., Krawczyk, N. & Fehm, T. Liquid biopsy in breast cancer. Geburtshilfe Frauenheilkd 80, 1093–1104….

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mtDNA Sequencing – Genetika

A new method for sequencing the mitochondrial genome by using long read technology Mitochondrial DNA (mtDNA or mDNA) is the DNA located in mitochondria, cellular organelles within eukaryotic cells that convert chemical energy from food into a form that cells can use, adenosine triphosphate (ATP). Mitochondrial DNA is only a…

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Visualization of mitochondrial cristae and mtDNA evolvement and interactions with super-resolution microscopy

Abstract Mitochondrial cristae host the respiratory chain complexes composed of mitochondrial DNA (mtDNA)-encoded and nuclear-encoded proteins and are responsible for ATP production. Movement of mtDNA located in the matrix is limited due to blockade by the cristae; yet, the dynamic interaction between the inner membrane and mtDNA remains unknown due…

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Halomonas venusta | 39 Publications | 938 Citations | Top Authors

Abstract: The microbial composition of smear-ripened cheeses is not very clear. A total of 194 bacterial isolates and 187 yeast isolates from the surfaces of four Irish farmhouse smear-ripened cheeses were identified at the midpoint of ripening using pulsed-field gel electrophoresis (PFGE), repetitive sequence-based PCR, and 16S rRNA gene sequencing…

Continue Reading Halomonas venusta | 39 Publications | 938 Citations | Top Authors

Paternal aging impacts mitochondrial DNA content and telomere length in mouse embryos

Advanced paternal age results in low fertility, regardless of natural or assisted reproductive technology (Brandt et al., 2019, Kovac et al., 2013). Furthermore, the offspring of aged male subjects reportedly exhibit an increased risk of childhood cancer, psychological disease, and obstetrical complications (Brandt et al., 2019, Kovac et al., 2013)….

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Integrated taxonomy reveals new threatened freshwater mussels (Bivalvia: Hyriidae: Westralunio) from southwestern Australia

Genetic variation The best fitting substitution models for COI codons 1–3 were identified as TN + F + G4, F81 + F + I, and TN + F, respectively. The maximum likelihood (ML) and Bayesian inference (BI) trees showed similar topologies of the main nodes, although the BI tree displayed greater resolution of the ingroup branches (Fig. 1). Furthermore, the BI…

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Title: The interplay between mitochondrial genome integrity and mitochondrial physiology in heteroplasmic cells

The Graduate School LSM offers an international doctoral programme to motivated and excellent academically qualified next generation researchers at one of Europe’s top Universities. LSM calls for doctoral applications on a yearly basis, open from the 1st of October until the 30th of November 2022. Mitochondria are known as the…

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Mitochondrial myopathies due to mtDNA muts are inherited solely in a maternal

Mitochondrial myopathies due to mtDNAmuts are inherited solely in a maternalfashion (i.e. maternal inheritence).Therefore, transmission occurs only thruaffected females and never thru males.Mitochondrial myopathy• CNS and skeletal muscles affected first• Weakness,lactic acidosis, ragged redfibers, neuropathy, seizures• Maternal inheritance xLinkeddominant• Rett, Alport, Fragile X• All female children of affect males willhave…

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Forensic Science Mitochondrial DNA Analysis.pdf – What are the advantages and disadvantages of mitochondrial DNA analysis? Could a police officer take a

What are the advantages and disadvantages of mitochondrial DNA analysis? Could apolice officer take a DNA sample from a suspect arrested for a serious crime? Explain.Mitochondrial DNA analysis is one of the tools that crime scene investigators use tosolve crimes. In this essay I will define mitochondrial DNA analysis, discuss…

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Anyone know how mtDNA is used as evidence for migration and interbreeding between early hominin species : vce

mtDNA is passed down the Maternal line and hence it does no under recombination. It also has a higher mutation rate meaning that differences can be accumulated within the mtDNA. This allows for scientists to determine the evolutionary relationship between species. More differences meaning they diverged a long time ago,…

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Infantile encephalopathy and defective mitochondrial DNA translation in patients with mutations of mitochondrial elongation factors EFG1 and EFTu

Mitochondrial protein translation is a complex process performed within mitochondria by an apparatus composed of mitochondrial DNA (mtDNA)-encoded RNAs and nuclear DNA -encoded proteins. Although the latter by far outnumber the former, the vast majority of mitochondrial translation defects in humans have been associated with mutations in RNA-encoding mtDNA genes,…

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Simplified Table Of Nations YDNA and MTDNA by kazumikikuchi on DeviantArt

Mix of Shem and Japheth in the Male Line and Female Line Haplogroup L3, YDNA CT, and YDNA DE or equally descended from Shem and JaphethSouth East AsiansEast AsiansMiddle EasternersNorthern AfricansSouth AsiansSouthern Europeans Shem in the female line and Japheth in the Male line, L3 in Female Line and YDNA…

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In a typical ZFY/ZFX DNA sequence sex-identification

In a typical ZFY/ZFX DNA sequence sex-identification test: Select one: a. Females mammals have no bands but males have ZFY. b.The test relies on protein from each sex being different. c. None of these d. Mitochondrial DNA is used. For species identification of animal products: Select one: a. mtDNA is…

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Solved Fredrick Wilson and his colleagues studied members of

Transcribed image text: Fredrick Wilson and his colleagues studied members of a large family who had low levels of magnesium in their blood (see the pedigree). They argued that this disorder of magnesium (and associated high blood pressure and high cholesterol) is caused by a mutation in mtDNA (F. H….

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Remains buried in Romania identified as Kansas airman killed during WWII

WICHITA, Kan. (KWCH) – The Defense POW/MIA Accounting Agency (DPAA) on Tuesday announced remains of a 23-year-old U.S. Army Air Forces staff sergeant from Seneca, Kansas were accounted for in July. The DPAA said the remains of Staff Sgt. Moses F. Tate were buried in Romania. “In the summer of 1943,…

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PRIME PubMed | Genetic evidence for a single stock of the deep-sea teleost Beryx decadactylus in the North Atlantic Ocean as inferred from mtDNA control region analysis

Citation Friess, C, and G R. Sedberry. “Genetic Evidence for a Single Stock of the Deep-sea Teleost Beryx Decadactylus in the North Atlantic Ocean as Inferred From mtDNA Control Region Analysis.” Journal of Fish Biology, vol. 78, no. 2, 2011, pp. 466-78. Friess C, Sedberry GR. Genetic evidence for a…

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Unveiling new perspective of phylogeography, genetic diversity, and population dynamics of Southeast Asian and Pacific chickens

Food and Agriculture Organization. The state of the world’s animal genetic resources for food and agriculture (Rome, 2007). Lawler, A. Dawn of the chicken revealed in Southeast Asia. Science 368, 1411 (2020). ADS  CAS  PubMed  Article  Google Scholar  Sykes, N. A social perspective on the introduction of exotic animals: the…

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Where can I find a free mtDNA database?

MitoVariome A freely available database of 5344 mtDNA sequences from around the world. Geni.com. Geni.com introduced DNA matching in July 2016. Customers can integrate their Y-DNA, mtDNA and autosomal DNA results from Family Tree DNA with their Geni tree. [0] One may also ask, What is ancient mtDNA database? Welcome…

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IJMS | Free Full-Text | Anatomical Laser Microdissection of the Ileum Reveals mtDNA Depletion Recovery in A Mitochondrial Neuro-Gastrointestinal Encephalomyopathy (MNGIE) Patient Receiving Liver Transplant

MDPI and ACS Style Boschetti, E.; Caporali, L.; D’Angelo, R.; Malagelada, C.; Accarino, A.; Dotti, M.T.; Costa, R.; Cenacchi, G.; Pironi, L.; Rinaldi, R.; Stanghellini, V.; Ratti, S.; Manzoli, L.; Carelli, V.; De Giorgio, R. Anatomical Laser Microdissection of the Ileum Reveals mtDNA Depletion Recovery in A Mitochondrial Neuro-Gastrointestinal Encephalomyopathy…

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Human Races .docx – Human Race(s) Introduction Based on the information given, the predicted results would be that people from the same region will be

Human Race(s)IntroductionBased on the information given, the predicted results would be that people from thesame region will be more alike than people from other regions of the world. It is predicted thatthe mtDNA sequences from people of the same region will be more similar, and the sequenceswhile crossing different sub-species…

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Yale Scientists Zero In on Genetic Causes of Parkinson’s Disease

New research by Yale researchers offers important clues into the genetic causes of Parkinson’s disease, a severe and incurable motor disorder. Although the development of Parkinson’s disease has been closely linked to variants of at least 20 different genes, scientists are still investigating exactly how they cause the severe and…

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Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway

Although it is an essential nutrient, high choline intake directly or indirectly via its metabolite is associated with increased risk of cardiovascular disease, the mechanism of which remains to be elucidated. The present study was performed to investigate whether hydrogen sulfide (H2S) was involved in high choline-induced cardiac dysfunction and…

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Probing the Mammalian Mitochondrial Nucleoid

dc.contributor.author Rajala, Nina dc.date.accessioned 2015-04-29T04:47:49Z dc.date.available 2015-04-29T04:47:49Z dc.date.issued 2015 dc.identifier.isbn 978-951-44-9794-0 – dc.identifier.uri trepo.tuni.fi/handle/10024/96996 dc.description.abstract Mitokondrioiden tärkein tehtävä on energian tuottaminen. Mitokondriot ovat solujen hengityskeskuksia, joissa 90 % tarvitsemastamme energiasta tuotetaan oksidatiivisen fosforylaation kautta elektroninsiirtoketjua apuna käyttäen. Kun mitokondriot eivät toimi kunnolla, tuloksena voi olla energiakriisi, erityisesti lihaksissa, aivoissa ja…

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Two New Studies Close In on the Genetic Underpinnings of Parkinson’s Disease

Variants of at least 20 different genes have been closely linked to the development of Parkinson’s disease, but scientists are still investigating how exactly they cause the severe and incurable motor disorder that afflicts about 1 million people in the U.S. alone. New research by Yale researchers offers important clues….

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(PDF) High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium | Ana Goios

(PDF) High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium | Ana Goios – Academia.edu Academia.edu no longer supports Internet Explorer. To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser. Log in with FacebookLog in with…

Continue Reading (PDF) High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium | Ana Goios

Genetic Divergence between auxis thazard and a.rochei based on pcr-rflp analysis of mtdna d-loop region

Tunas of genus Auxis are commercially and ecologically important fish of family Scombridae. There is currently no information concerning the genetic divergence between A. thazard and A. rochei. Therefore, a study was conducted to estimate the degree of genetic divergence between two species based on PCR-RFLP analysis of D -loop…

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Dissertations.se: MITOCHONDRIAL DNA REPLICATION

Showing result 1 – 5 of 29 swedish dissertations containing the words Mitochondrial DNA replication. Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA;…

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b30_m7_l06_assign.docx.pdf – Biology 30: Module 7: Lesson 6 1 Assignment MODULE 7: LESSON 6 ASSIGNMENT This Module 7: Lesson 6 Assignment is worth 14

Unformatted text preview: Biology 30: Module 7: Lesson 6 1 Assignment MODULE 7: LESSON 6 ASSIGNMENT This Module 7: Lesson 6 Assignment is worth 14 marks. The value of each assignment and each question is stated in the left margin. Review the lesson online in ‘content’. In your eText, review…

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Cells | Free Full-Text | Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress Response

Hyperosmolality can occur during industrial fed-batch cultivation processes of Chinese hamster ovary (CHO) cells as highly concentrated feed and base solutions are added to replenish nutrients and regulate pH values. Some effects of hyperosmolality, such as increased cell size and growth inhibition, have been elucidated by previous research, but the…

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Role of mitochondrial DNA copy number in incident cardiovascular diseases and the association between cardiovascular disease and type 2 diabetes : A follow-up study on middle-aged women

@article{3a468481-6140-491c-b3ea-22a00f1d6e03, abstract = {{<p>BACKGROUND AND AIMS: Mitochondrial DNA copy number (mtDNA-CN) is a surrogate biomarker of mitochondrial dysfunction and is associated with type 2 diabetes (T2D) and cardiovascular disease (CVD). However, despite being associated with both CVD and T2D, it is not known what role mtDNA-CN has in the association…

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Dissertations.se: HETEROPLASMY

Showing result 1 – 5 of 7 swedish dissertations containing the word Heteroplasmy. Author : Guilherme Costa Baião; Lisa Klasson; Alistair Darby; Uppsala universitet; []Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Wolbachia; Drosophila; Drosophila paulistorum; Differential Gene Expression; Reproductive Incompatibility; Reproductive Isolation; Comparative Genomics; Transcriptomics; RNA-Seq; Heteroplasmy; Mitochondria; Genomic…

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(PDF) Intraspecific variability (rDNA ITS and mtDNA Cyt b) of Phlebotomus sergenti in Spain and Morocco | Montserrat Gallego

(PDF) Intraspecific variability (rDNA ITS and mtDNA Cyt b) of Phlebotomus sergenti in Spain and Morocco | Montserrat Gallego – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through the use of cookies….

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Author Correction: Genome-wide autosomal, mtDNA, and Y chromosome analysis of King Bela III of the Hungarian Arpad dynasty

Author Correction: Using energy time”“frequency of Hilbert Huang transform to analyze the performance of the variable valve timing engine Correction to: Scientific Reports doi.org/10.1038/s41598-022-06404-3, published online 11 February 2022. The original version of this Article contained errors in the Reference list, where references 1,2,4,5,12,13,14,15,18,21,22,23,34,36,37,39,40,41,42,43,44 and 45 were incorrectly given as….

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Mitogenome-wise codon usage pattern from comparative analysis of the first mitogenome of Blepharipa sp. (Muga uzifly) with other Oestroid flies

Outcome of DNA sequencing, assembly, and validation In this study, initially total DNA was isolated from the finely chopped, full-grown pupa of Blepharipa sp. The NanoDrop spectrophotometer (1294 ng/μl) and the Qubit fluorometer (732.8 ng/μl) both found that the concentration of total DNA in the sample at an optimum level for mitochondrial DNA enrichment. The Tape Station profile showed…

Continue Reading Mitogenome-wise codon usage pattern from comparative analysis of the first mitogenome of Blepharipa sp. (Muga uzifly) with other Oestroid flies

Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases

Craven L, Alston C, Taylor R, Turnbull D (2017) Recent advances in mitochondrial disease. Annu Rev Genomics Hum Genet 18:257–275. doi.org/10.1146/annurev-genom-091416-035426 CAS  Article  PubMed  Google Scholar  El-Hattab AW, Adesina AM, Jones J, Scaglia F (2015) MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab 116(1–2):4–12. doi.org/10.1016/j.ymgme.2015.06.004 CAS  Article …

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The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster,Nature Cell Biology

Mitochondrial DNA (mtDNA) replication and transcription are of paramount importance to cellular energy metabolism. Mitochondrial RNA polymerase is thought to be the primase for mtDNA replication. However, it is unclear how this enzyme, which normally transcribes long polycistronic RNAs, can produce short RNA oligonucleotides to initiate mtDNA replication. We show…

Continue Reading The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster,Nature Cell Biology

St. Landry Parish soldier accounted for after being declared MIA during World War II

A St. Landry Parish soldier declared missing in action during World War II has been accounted for, according to the Department of Defense. The Defense POW/MIA Accounting Agency (DPAA) announced Monday that 23-year-old Army Pvt. Hillary Soileau was accounted for Dec. 8, 2020. The Agency says that in January 1943,…

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About mtDNA

When forensic cases arise where there is insufficient biological material for nuclear DNA typing, mitochondrial DNA analysis can provide valuable supplemental information, even from such limited samples as half-centimeter long hair fragments or single teeth. Because of its usefulness when limited biological material is available, and due to its unique…

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(PDF) A highly divergent mtDNA sequence in a Neandertal individual from Italy | Lucio Milani

(PDF) A highly divergent mtDNA sequence in a Neandertal individual from Italy | Lucio Milani – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through the use of cookies. To learn more, view…

Continue Reading (PDF) A highly divergent mtDNA sequence in a Neandertal individual from Italy | Lucio Milani

Difference Between Mitochondrial DNA and Nuclear DNA

Deoxyribonucleic acid (DNA) carries genetic information that serves as a set of instructions for growth and development, as well as the ultimate function and reproduction of an organism. It is a nucleic acid, one of four major types of macromolecules known to be essential for all life forms. Each DNA molecule…

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Comparative genomic analysis of vertebrate mitochondrial reveals a differential of rearrangements rate between taxonomic class

Pereira, S. L. Mitochondrial genome organization and vertebrate phylogenetics. Genet. Mol. Biol. 23, 745–752 (2000). CAS  Google Scholar  Boore, J. L. Animal mitochondrial genomes. Nucl. Acids Res. 27, 1767–1780 (1999). CAS  PubMed  PubMed Central  Google Scholar  Formenti, G. et al. Complete vertebrate mitogenomes reveal widespread gene duplications and repeats. BioRxiv…

Continue Reading Comparative genomic analysis of vertebrate mitochondrial reveals a differential of rearrangements rate between taxonomic class

MitoScore, MitoGrade, or MitoSure: what does embryonic mitochondrial deoxyribonucleic acid quantification actually measure and is it useful?

VOLUME 3, ISSUE 1, P1-2, MARCH 01, 2022 Authors: Richard J. Paulson, M.D., M.S. Abstract: One of the keys to maximizing the efficiency of in vitro fertilization is the determination of which embryos have the greatest likelihood of implantation. This is the purpose of morphological assessment, time-lapse evaluation of embryonic…

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Phylogenomic analysis of Syngnathidae reveals novel relationships, origins of endemic diversity and variable diversification rates | BMC Biology

Stölting KN, Wilson AB. Male pregnancy in seahorses and pipefish: beyond the mammalian model. Bioessays. 2007;29:884–96. PubMed  Google Scholar  Whittington CM, Friesen CR. The evolution and physiology of male pregnancy in syngnathid fishes. Biol Rev Camb Philos Soc. 2020;95:1252–72. PubMed  Google Scholar  Rosenqvist G, Berglund A. Sexual signals and mating…

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STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

This article was originally published here Cell Death Dis. 2022 Mar 25;13(3):269. doi: 10.1038/s41419-022-04664-5. ABSTRACT Stimulator of interferon genes (STING) contributes to immune responses against tumors and may control viral infection including SARS-CoV-2 infection. However, activation of the STING pathway by airway silica or smoke exposure leads to cell death,…

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Got my results . curious about the mtdna haplogroup not being eroupean orgin? : 23andme

I wonder how common Bolivian users are in 23andMe and the impact for making it rare. I’m C1b4 from the Caribbean and it’s also fairly uncommon amongst 23andMe, though C maternal haplogroup is common in my Puerto Rican matches. Edit: If you trace your line directly via your mom’s line…

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Wuhan University Song Zhiyin and other teams discovered a new mechanism of mitochondrial DNA release

Sam50 is a key component of the sorting and assembly machinery (SAM) complex and is also involved in bridging mitochondrial outer and inner membrane contacts. However, the physiological and pathological functions of Sam50 remain largely unknown. On March 21, 2022, Wuhan University Song Zhiyin and Meng Qingtao jointly published a…

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Exercise 13: Mitochondrial DNA (mtDNA) Analysis

Mitochondrial DNA (mtDNA) typing is increasingly used in human identity testing when biological evidence may be degraded, when quantities of the samples in question are limited, or when nuclear DNA typing is not an option. Forensically relevant biological sources of mtDNA include, but are not limited to, hairs, bones, and…

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Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury

doi: 10.3389/fnmol.2022.852243. eCollection 2022. Lauren E Fritsch  1 , Jing Ju  2 , Erwin Kristobal Gudenschwager Basso  3 , Eman Soliman  3 , Swagatika Paul  4 , Jiang Chen  2 , Alexandra M Kaloss  3 , Elizabeth A Kowalski  3 , Taylor C Tuhy  5 , Rachana Deven Somaiya  1 , Xia Wang  3 , Irving Coy Allen  3 , Michelle H…

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Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A

dc.identifier.citation Lepelley , A , Della Mina , E , Van Nieuwenhove , E , Waumans , L , Fraitag , S , Rice , G I , Dhir , A , Fremond , M-L , Rodero , M P , Seabra , L , Carter , E , Bodemer…

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Mitochondrial DNA Sequencing | AlphaBiolabs UK

Why choose mitochondrial DNA analysis? Mitochondria contains an independent, circular genome, 16,569 base pairs in length, including a non-coding control region of approximately 1160 base pairs. Each eukaryotic cell contains 100-10,000 copies of mitochondrial DNA (mtDNA), a much higher copy number in comparison to nuclear DNA; this high copy number means…

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Genetic diversity of common carp (Cyprinus carpio L.) strains breed in Poland based on microsatellite, AFLP, and mtDNA genotype data.

Abstract Abstract The common carp (Cyprinus carpio L.) has a long-standing history in Polish pond aquaculture, which has given rise to a great number of local breeds, strains and hatchery populations. They are well adapted to their local conditions, play an important role for fisherman’s livelihoods and…

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Mechanisms involved in the transmission of genetic diseases from mother to child

Mitochondria are the organelles that produce most of the chemical energy needed by the cell. Mitochondrial DNA (mtDNA) contains 16,569 nucleotides that can be mutated. Some of these mutations can lead to the development of mitochondrial diseases. While nuclear DNA (the well-known double helix, which encodes most of the genome)…

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Research reveals mechanism involved in transm

image: Immature mouse egg at a stage prior to ovulation, with mitochondria stained red view more  Credit: Marcos Roberto Chiaratti A research article published in the journal Science Advances describes a mechanism that helps explain how certain kinds of genetic disorders known as mitochondrial diseases are transmitted from mother to child. The study it reports…

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The Clam Cyclina sinensis (Gmelin) Phylogeography Study with 28S rRNA Gene and Potential of Nuclear rRNA Genes in Genetic Assessments of Molluscs

Avise, J. C., 2009. Phylogeography: Retrospect and prospect. Journal of Biogeography, 36: 3–15. Article  Google Scholar  Beheregaray, L. B., 2008. Twenty years of phylogeography: The state of the field and the challenges for the Southern Hemisphere. Molecular Ecology, 17: 3754–3774. Google Scholar  Clement, M., Posada, D., and Crandall, K. A.,…

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Autophagy deficiency abolishes liver mitochondrial DNA segregation

Mutations in the mitochondrial genome (mtDNA) are ubiquitous in humans and can lead to a broad spectrum of disorders. However, due to the presence of multiple mtDNA molecules in the cell, co-existence of mutant and wild-type mtDNAs (termed heteroplasmy) can mask disease phenotype unless a threshold of mutant molecules is…

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BSCI 207 Unit 1 Exam Practice Problems.pdf – Unit 1 Exam Practice Problems 1) Correctly rank the rate of change for mtDNA, nuclear DNA, and rRNA where

Unit 1 Exam Practice Problems1)Correctly rank the rate of change for mtDNA, nuclear DNA, and rRNA where theleftmost term changes the quickest, while the rightmost term changes the slowesta.Nuclear DNA, mtDNA, rRNAb.mtDNA, nuclear DNA, rRNAc.mtDNA, rRNA, nuclear DNAd.rRNA, mtDNA, nuclear DNA 2)If a reaction was spontaneous, which of the following…

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Dissertations.se: INITIATION OF DNA REPLICATION

Showing result 1 – 5 of 43 swedish dissertations containing the words initiation of DNA replication. Author : Elisabeth Jemt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; mtDNA; DNA replication; Abstract : Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and…

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Scientific Seminar – ONLINE SEMINAR

Scientific Seminar – ONLINE SEMINAR Date: Feb 18, 2022 Time: 13:00 c.t. – 14:00 Speaker: Laura Kremer Karolinska Institutet, Stockholm, Schweden Location: Max-Planck-Institut für Multidisziplinäre Naturwissenschaften (MPI-NAT, Faßberg-Campus) Room: Zoom Host: Ursula Fünfschilling Contact: fuenfschilling@mpinat.mpg.de In 1865 Gregor Mendel discovered the principles of nuclear genetics. More than 150 years later,…

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Haplogroup L3 (mtDNA) – Wikipedia @ WordDisk

Haplogroup L3 is a human mitochondrial DNA (mtDNA) haplogroup. The clade has played a pivotal role in the early dispersal of anatomically modern humans. Widespread human mitochondrial DNA grouping indicating common ancestry Haplogroup L3 Possible time of origin 80,000–60,000 YBP[1] Possible place of origin East Africa[2][3][4] or Asia[5] Ancestor L3’4…

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Mitochondrial DNA content reduction in the most fertile spermatozoa is accompanied by increased mitochondrial DNA rearrangement

Study question: Is there an association between male fertility and spermatozoa mitochondrial DNA (mtDNA) copy number and genome rearrangements? Summary answer: Normal spermatozoa not only have a lower mtDNA copy number but also more DNA rearrangements than spermatozoa of men with severe oligoasthenospermia (SOA). What is known already: While there…

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The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

Abstract The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure, myocardial infarction,…

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The fate of damaged mitochondrial DNA in the cell

Available online 5 February 2022, 119233 doi.org/10.1016/j.bbamcr.2022.119233Get rights and content Highlights • Mitochondrial DNA (mtDNA) is a key component of mitochondrion and essential for maintaining mitochondrial function. • mtDNA damage leads to mitochondrial dysfunction and is related to the occurrence of mitochondrial diseases. • Upon mtDNA damage, cell has multiple…

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Library Event Calendar | City of Palm Springs

Making YDNA and mtDNA Part of Your Family History     This Zoom event is presented by the Palm Springs Genealogical Society with guest speaker Diana Southard. After getting bitten by the DNA bug as a high school student, Diana went on to study at Brigham Young University where she earned…

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Mitochondrial DNA variation across 56,434 individuals in gnomAD

Genomic databases of allele frequency are extremely helpful for evaluating clinical variants of unknown significance; however, until now, databases such as the Genome Aggregation Database (gnomAD) have focused on nuclear DNA and have ignored the mitochondrial genome (mtDNA). Here we present a pipeline to call mtDNA variants that addresses three…

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DNA Labs International Launches the Newest Technology for Forensic Genetic Genealogy

MiSeq FGx platform by Verogen DEERFIELD BEACH, Fla. (PRWEB) January 26, 2022 DNA Labs International, which specializes in forensic DNA analysis including forensic genetic genealogy (FGG) for law enforcement agencies, government forensic labs, and attorneys, is announcing the release of their newest technology, Single Nucleotide Polymorphism (SNP) testing with…

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Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review

Summary Background Mitochondrial DNA (mtDNA) encodes 37 genes necessary for synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA alterations are known to cause mitochondrial disease (MitD), a clinically heterogeneous group of disorders that often present with neuropsychiatric symptoms. Understanding the nature and frequency of mtDNA alterations in health…

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Avian mtDNA primers

Avian mtDNA Primers The PDF file below provides details on a complete set of primers for amplifying and sequencing avian mitochondrial DNA. All of the primers have been designed to work with most or all birds and most perform very well in this regard. The document is intended as a…

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A Study on Polymorphism of Mitochondrial DNA (mtDNA) in Populations of D.virilis Distributing in Chinese Continent

JIA Zhen-yu, ZHU Ding-liang, GENG Zhen-cheng, T.Aotsuka. A Study on Polymorphism of Mitochondrial DNA (mtDNA) in Populations of D.virilis Distributing in Chinese Continent. Zoological Research, 1995, 16(1): 65-73. Citation: JIA Zhen-yu, ZHU Ding-liang, GENG Zhen-cheng, T.Aotsuka. A Study on Polymorphism of Mitochondrial DNA (mtDNA) in…

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Why is mtDNA maternal only? : explainlikeimfive

Mitochondria are kind of like an in-between of cell-organelles and bacteria that live in your cells. They are not made by your cells, but they replicate on their own (by splitting in two). For this, they use their own DNA (the mtDNA), not the DNA of your cells. When an…

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GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

Background: Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to capture underlying mitochondrial function. The specific biological processes underpinning its regulation, and whether those processes are causative for disease, is an area of active investigation. Methods: We developed a novel method for array-based mtDNA-CN estimation suitable for…

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Genetic diversity and selection in Puerto Rican horses

Horses have been considered one of our most prized possessions, used for travel, work, food, and pleasure for at least five and a half millennia17,18,19,20. Nevertheless, the ancestry of various horse breeds and their characteristic traits remains unclear21. In this paper, we describe the patterns and the origins of genetic…

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Estimating individual mtDNA haplotypes in mixed DNA samples by combining MinION and MiSeq

doi: 10.1007/s00414-021-02763-0. Online ahead of print. Affiliations Expand Affiliations 1 Department of Forensic Medicine, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan. hnakani@juntendo.ac.jp. 2 Department of Forensic Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Saitama, 350-0495, Japan. 3 Department of Forensic Medicine, Juntendo University School of Medicine,…

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Global mtDNA Databasing Project | National Institute of Justice

Global mtDNA Databasing Project: AFDIL intends to greatly increase the size and quality of global forensic mtDNA databases openly available to the forensic practitioner community. Using a proven system for high throughput, robotic sequencing, AFDIL will sequence the entire mtDNA control region (CR) of 7,500 target individuals, over a two…

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DNA in Unlikely Places Helps Piece Together Ancient Humans’ Family Trees

This story was originally published in our January/February 2022 issue. Click here to subscribe to read more stories like this one. One hundred thousand years ago, Neanderthals gathered in a cave perched 3,000 feet up in present-day Spain’s Atapuerca Mountains. While cooking and watching youngsters wrestle, they littered the floor with DNA…

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Radboud University Medical Center Increases HiFi Sequencing Capacity with PacBio’s Sequel IIe

Added whole genome sequencing capacity enables the SOLVE-RD research program to significantly increase sample throughput MENLO PARK, Calif., Jan. 07, 2022 (GLOBE NEWSWIRE) — PacBio (Nasdaq: PACB), a leading developer of high-quality, highly accurate sequencing platforms, today announced Radboud University Medical Center (Radboudumc) in Nijmegen, the Netherlands will increase their…

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Genetic diagnosis of basal ganglia disease in childhood

This article was originally published here Dev Med Child Neurol. 2022 Jan 5. doi: 10.1111/dmcn.15125. Online ahead of print. ABSTRACT AIM: To correlate clinical, radiological, and biochemical features with genetic findings in children with bilateral basal ganglia lesions of unknown aetiology, and propose a diagnostic algorithm for early recognition. METHOD:…

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Human Mitochondrial Genome Feature Table for GenBank BankIt

Human Mitochondrial Genome Feature Table for GenBank BankIt 0 Hello Bioinfo Stars, I would like to submit human mitochondrial genome sequences to GenBank using BankIt portal, but encountered problem with the preparation of the five column Feature Table. As you may know, Feature Table for mitochondrial genomes of Metazoa (i.e….

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Dissertations.se: MITOCHONDRIAL CARDIOMYOPATHY

Showing result 1 – 5 of 9 swedish dissertations containing the words mitochondrial cardiomyopathy. Author : Gittan Kollberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Mitochondrial Disorders; mtDNA; multiple mtDNA deletions; Alpers-Huttenlocher syndrome; POLG1; GYS1; glycogen synthase; point mutation; Polymerase…

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Haplogroup M (mtDNA)

In human genetics, Haplogroup M is a human mitochondrial DNA (mtDNA) haplogroup. An enormous haplogroup spanning many continents, the macro-haplogroup M is a branch of the haplogroup L3. M is believed to have originated in Asia [Gonzalez et al., [www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1945034 Mitochondrial lineage M1 traces an early human backflow to Africa]…

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Publication A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA.

Your browser does not have JavaScript enabled. Some parts of this website may require JavaScript to function correctly First Author  Hashizume O Year  2015 Journal  PLoS One Volume  10 Issue  3 Pages  e0118561 PubMed ID  25738506 Mgi Jnum  J:233444 Mgi Id  MGI:5784636 Doi  10.1371/journal.pone.0118561 Citation  Hashizume O, et al. (2015)…

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Non-random tissue distribution of mutant mtDNA – ePrints

Non-random tissue distribution of mutant mtDNA Lookup NU author(s): Professor Patrick Chinnery, Professor Mark Walker, Professor Robert Taylor, Professor Robert Lightowlers, Professor Laurence Bindoff, Emeritus Professor Doug Turnbull Downloads Full text for this publication is not currently held within this repository. Alternative links…

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Which best describes mitochondrial dna (mtdna)?

Mitochondrial DNA of human cells only encodes for a small percentage of proteins that function in mitochondria 3. This pedigree describes the inheritance of a mutation that affects mitochondria function. Which of the proteins below is most likely affected by this mutation? Please note: circles refer to females, squares refer…

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Nuclear Genome-Encoded Long Noncoding RNAs and Mitochondrial Damage in Diabetic Retinopathy

. 2021 Nov 23;10(12):3271. doi: 10.3390/cells10123271. Affiliations Expand Affiliations 1 Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA. 2 Kresge Eye Institute, 4717 St. Antoine, Detroit, MI 48201, USA. Item in Clipboard Ghulam Mohammad et al. Cells. 2021. Show details Display options Display options Format…

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mtDNA Brick Wall in 1773 NH – can anyone help identify parents?

I could really use the help of an expert New England genealogist to break through a long-standing mtDNA brick wall.  Our mtDNA results could be very helpful to others if we can push our maternal line back a few more generations. My direct maternal-line fourth-great-grandmother, [[Johnson-99341|Sarah (Johnson) Haven (1773-1836)]], was born…

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Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus

Objectives: Cell-free DNA is involved in the pathogenesis of systemic lupus erythematosus (SLE) but the clinical value of cell-free DNA measurements in SLE is unknown. Our aim was therefore to examine the utility of mitochondrial (mt) DNA and nuclear (n) DNA quantification in SLE. Methods: EDTA plasma was drawn from…

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