Tag: mtDNA

Remains buried in Romania identified as Kansas airman killed during WWII

WICHITA, Kan. (KWCH) – The Defense POW/MIA Accounting Agency (DPAA) on Tuesday announced remains of a 23-year-old U.S. Army Air Forces staff sergeant from Seneca, Kansas were accounted for in July. The DPAA said the remains of Staff Sgt. Moses F. Tate were buried in Romania. “In the summer of 1943,…

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PRIME PubMed | Genetic evidence for a single stock of the deep-sea teleost Beryx decadactylus in the North Atlantic Ocean as inferred from mtDNA control region analysis

Citation Friess, C, and G R. Sedberry. “Genetic Evidence for a Single Stock of the Deep-sea Teleost Beryx Decadactylus in the North Atlantic Ocean as Inferred From mtDNA Control Region Analysis.” Journal of Fish Biology, vol. 78, no. 2, 2011, pp. 466-78. Friess C, Sedberry GR. Genetic evidence for a…

Continue Reading PRIME PubMed | Genetic evidence for a single stock of the deep-sea teleost Beryx decadactylus in the North Atlantic Ocean as inferred from mtDNA control region analysis

Unveiling new perspective of phylogeography, genetic diversity, and population dynamics of Southeast Asian and Pacific chickens

Food and Agriculture Organization. The state of the world’s animal genetic resources for food and agriculture (Rome, 2007). Lawler, A. Dawn of the chicken revealed in Southeast Asia. Science 368, 1411 (2020). ADS  CAS  PubMed  Article  Google Scholar  Sykes, N. A social perspective on the introduction of exotic animals: the…

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Where can I find a free mtDNA database?

MitoVariome A freely available database of 5344 mtDNA sequences from around the world. Geni.com. Geni.com introduced DNA matching in July 2016. Customers can integrate their Y-DNA, mtDNA and autosomal DNA results from Family Tree DNA with their Geni tree. [0] One may also ask, What is ancient mtDNA database? Welcome…

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IJMS | Free Full-Text | Anatomical Laser Microdissection of the Ileum Reveals mtDNA Depletion Recovery in A Mitochondrial Neuro-Gastrointestinal Encephalomyopathy (MNGIE) Patient Receiving Liver Transplant

MDPI and ACS Style Boschetti, E.; Caporali, L.; D’Angelo, R.; Malagelada, C.; Accarino, A.; Dotti, M.T.; Costa, R.; Cenacchi, G.; Pironi, L.; Rinaldi, R.; Stanghellini, V.; Ratti, S.; Manzoli, L.; Carelli, V.; De Giorgio, R. Anatomical Laser Microdissection of the Ileum Reveals mtDNA Depletion Recovery in A Mitochondrial Neuro-Gastrointestinal Encephalomyopathy…

Continue Reading IJMS | Free Full-Text | Anatomical Laser Microdissection of the Ileum Reveals mtDNA Depletion Recovery in A Mitochondrial Neuro-Gastrointestinal Encephalomyopathy (MNGIE) Patient Receiving Liver Transplant

Human Races .docx – Human Race(s) Introduction Based on the information given, the predicted results would be that people from the same region will be

Human Race(s)IntroductionBased on the information given, the predicted results would be that people from thesame region will be more alike than people from other regions of the world. It is predicted thatthe mtDNA sequences from people of the same region will be more similar, and the sequenceswhile crossing different sub-species…

Continue Reading Human Races .docx – Human Race(s) Introduction Based on the information given, the predicted results would be that people from the same region will be

Yale Scientists Zero In on Genetic Causes of Parkinson’s Disease

New research by Yale researchers offers important clues into the genetic causes of Parkinson’s disease, a severe and incurable motor disorder. Although the development of Parkinson’s disease has been closely linked to variants of at least 20 different genes, scientists are still investigating exactly how they cause the severe and…

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Hydrogen Sulfide Ameliorated High Choline-Induced Cardiac Dysfunction by Inhibiting cGAS-STING-NLRP3 Inflammasome Pathway

Although it is an essential nutrient, high choline intake directly or indirectly via its metabolite is associated with increased risk of cardiovascular disease, the mechanism of which remains to be elucidated. The present study was performed to investigate whether hydrogen sulfide (H2S) was involved in high choline-induced cardiac dysfunction and…

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Probing the Mammalian Mitochondrial Nucleoid

dc.contributor.author Rajala, Nina dc.date.accessioned 2015-04-29T04:47:49Z dc.date.available 2015-04-29T04:47:49Z dc.date.issued 2015 dc.identifier.isbn 978-951-44-9794-0 – dc.identifier.uri trepo.tuni.fi/handle/10024/96996 dc.description.abstract Mitokondrioiden tärkein tehtävä on energian tuottaminen. Mitokondriot ovat solujen hengityskeskuksia, joissa 90 % tarvitsemastamme energiasta tuotetaan oksidatiivisen fosforylaation kautta elektroninsiirtoketjua apuna käyttäen. Kun mitokondriot eivät toimi kunnolla, tuloksena voi olla energiakriisi, erityisesti lihaksissa, aivoissa ja…

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Two New Studies Close In on the Genetic Underpinnings of Parkinson’s Disease

Variants of at least 20 different genes have been closely linked to the development of Parkinson’s disease, but scientists are still investigating how exactly they cause the severe and incurable motor disorder that afflicts about 1 million people in the U.S. alone. New research by Yale researchers offers important clues….

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(PDF) High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium | Ana Goios

(PDF) High-resolution mtDNA evidence for the late-glacial resettlement of Europe from an Iberian refugium | Ana Goios – Academia.edu Academia.edu no longer supports Internet Explorer. To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser. Log in with FacebookLog in with…

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Genetic Divergence between auxis thazard and a.rochei based on pcr-rflp analysis of mtdna d-loop region

Tunas of genus Auxis are commercially and ecologically important fish of family Scombridae. There is currently no information concerning the genetic divergence between A. thazard and A. rochei. Therefore, a study was conducted to estimate the degree of genetic divergence between two species based on PCR-RFLP analysis of D -loop…

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Dissertations.se: MITOCHONDRIAL DNA REPLICATION

Showing result 1 – 5 of 29 swedish dissertations containing the words Mitochondrial DNA replication. Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA;…

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b30_m7_l06_assign.docx.pdf – Biology 30: Module 7: Lesson 6 1 Assignment MODULE 7: LESSON 6 ASSIGNMENT This Module 7: Lesson 6 Assignment is worth 14

Unformatted text preview: Biology 30: Module 7: Lesson 6 1 Assignment MODULE 7: LESSON 6 ASSIGNMENT This Module 7: Lesson 6 Assignment is worth 14 marks. The value of each assignment and each question is stated in the left margin. Review the lesson online in ‘content’. In your eText, review…

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Cells | Free Full-Text | Single-Cell Analysis of CHO Cells Reveals Clonal Heterogeneity in Hyperosmolality-Induced Stress Response

Hyperosmolality can occur during industrial fed-batch cultivation processes of Chinese hamster ovary (CHO) cells as highly concentrated feed and base solutions are added to replenish nutrients and regulate pH values. Some effects of hyperosmolality, such as increased cell size and growth inhibition, have been elucidated by previous research, but the…

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Role of mitochondrial DNA copy number in incident cardiovascular diseases and the association between cardiovascular disease and type 2 diabetes : A follow-up study on middle-aged women

@article{3a468481-6140-491c-b3ea-22a00f1d6e03, abstract = {{<p>BACKGROUND AND AIMS: Mitochondrial DNA copy number (mtDNA-CN) is a surrogate biomarker of mitochondrial dysfunction and is associated with type 2 diabetes (T2D) and cardiovascular disease (CVD). However, despite being associated with both CVD and T2D, it is not known what role mtDNA-CN has in the association…

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Dissertations.se: HETEROPLASMY

Showing result 1 – 5 of 7 swedish dissertations containing the word Heteroplasmy. Author : Guilherme Costa Baião; Lisa Klasson; Alistair Darby; Uppsala universitet; []Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Wolbachia; Drosophila; Drosophila paulistorum; Differential Gene Expression; Reproductive Incompatibility; Reproductive Isolation; Comparative Genomics; Transcriptomics; RNA-Seq; Heteroplasmy; Mitochondria; Genomic…

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(PDF) Intraspecific variability (rDNA ITS and mtDNA Cyt b) of Phlebotomus sergenti in Spain and Morocco | Montserrat Gallego

(PDF) Intraspecific variability (rDNA ITS and mtDNA Cyt b) of Phlebotomus sergenti in Spain and Morocco | Montserrat Gallego – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through the use of cookies….

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Author Correction: Genome-wide autosomal, mtDNA, and Y chromosome analysis of King Bela III of the Hungarian Arpad dynasty

Author Correction: Using energy time”“frequency of Hilbert Huang transform to analyze the performance of the variable valve timing engine Correction to: Scientific Reports doi.org/10.1038/s41598-022-06404-3, published online 11 February 2022. The original version of this Article contained errors in the Reference list, where references 1,2,4,5,12,13,14,15,18,21,22,23,34,36,37,39,40,41,42,43,44 and 45 were incorrectly given as….

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Mitogenome-wise codon usage pattern from comparative analysis of the first mitogenome of Blepharipa sp. (Muga uzifly) with other Oestroid flies

Outcome of DNA sequencing, assembly, and validation In this study, initially total DNA was isolated from the finely chopped, full-grown pupa of Blepharipa sp. The NanoDrop spectrophotometer (1294 ng/μl) and the Qubit fluorometer (732.8 ng/μl) both found that the concentration of total DNA in the sample at an optimum level for mitochondrial DNA enrichment. The Tape Station profile showed…

Continue Reading Mitogenome-wise codon usage pattern from comparative analysis of the first mitogenome of Blepharipa sp. (Muga uzifly) with other Oestroid flies

Circulating cell-free mtDNA release is associated with the activation of cGAS-STING pathway and inflammation in mitochondrial diseases

Craven L, Alston C, Taylor R, Turnbull D (2017) Recent advances in mitochondrial disease. Annu Rev Genomics Hum Genet 18:257–275. doi.org/10.1146/annurev-genom-091416-035426 CAS  Article  PubMed  Google Scholar  El-Hattab AW, Adesina AM, Jones J, Scaglia F (2015) MELAS syndrome: clinical manifestations, pathogenesis, and treatment options. Mol Genet Metab 116(1–2):4–12. doi.org/10.1016/j.ymgme.2015.06.004 CAS  Article …

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The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster,Nature Cell Biology

Mitochondrial DNA (mtDNA) replication and transcription are of paramount importance to cellular energy metabolism. Mitochondrial RNA polymerase is thought to be the primase for mtDNA replication. However, it is unclear how this enzyme, which normally transcribes long polycistronic RNAs, can produce short RNA oligonucleotides to initiate mtDNA replication. We show…

Continue Reading The PPR domain of mitochondrial RNA polymerase is an exoribonuclease required for mtDNA replication in Drosophila melanogaster,Nature Cell Biology

St. Landry Parish soldier accounted for after being declared MIA during World War II

A St. Landry Parish soldier declared missing in action during World War II has been accounted for, according to the Department of Defense. The Defense POW/MIA Accounting Agency (DPAA) announced Monday that 23-year-old Army Pvt. Hillary Soileau was accounted for Dec. 8, 2020. The Agency says that in January 1943,…

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About mtDNA

When forensic cases arise where there is insufficient biological material for nuclear DNA typing, mitochondrial DNA analysis can provide valuable supplemental information, even from such limited samples as half-centimeter long hair fragments or single teeth. Because of its usefulness when limited biological material is available, and due to its unique…

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(PDF) A highly divergent mtDNA sequence in a Neandertal individual from Italy | Lucio Milani

(PDF) A highly divergent mtDNA sequence in a Neandertal individual from Italy | Lucio Milani – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through the use of cookies. To learn more, view…

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Difference Between Mitochondrial DNA and Nuclear DNA

Deoxyribonucleic acid (DNA) carries genetic information that serves as a set of instructions for growth and development, as well as the ultimate function and reproduction of an organism. It is a nucleic acid, one of four major types of macromolecules known to be essential for all life forms. Each DNA molecule…

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Comparative genomic analysis of vertebrate mitochondrial reveals a differential of rearrangements rate between taxonomic class

Pereira, S. L. Mitochondrial genome organization and vertebrate phylogenetics. Genet. Mol. Biol. 23, 745–752 (2000). CAS  Google Scholar  Boore, J. L. Animal mitochondrial genomes. Nucl. Acids Res. 27, 1767–1780 (1999). CAS  PubMed  PubMed Central  Google Scholar  Formenti, G. et al. Complete vertebrate mitogenomes reveal widespread gene duplications and repeats. BioRxiv…

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MitoScore, MitoGrade, or MitoSure: what does embryonic mitochondrial deoxyribonucleic acid quantification actually measure and is it useful?

VOLUME 3, ISSUE 1, P1-2, MARCH 01, 2022 Authors: Richard J. Paulson, M.D., M.S. Abstract: One of the keys to maximizing the efficiency of in vitro fertilization is the determination of which embryos have the greatest likelihood of implantation. This is the purpose of morphological assessment, time-lapse evaluation of embryonic…

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Phylogenomic analysis of Syngnathidae reveals novel relationships, origins of endemic diversity and variable diversification rates | BMC Biology

Stölting KN, Wilson AB. Male pregnancy in seahorses and pipefish: beyond the mammalian model. Bioessays. 2007;29:884–96. PubMed  Google Scholar  Whittington CM, Friesen CR. The evolution and physiology of male pregnancy in syngnathid fishes. Biol Rev Camb Philos Soc. 2020;95:1252–72. PubMed  Google Scholar  Rosenqvist G, Berglund A. Sexual signals and mating…

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STING agonist diABZI induces PANoptosis and DNA mediated acute respiratory distress syndrome (ARDS)

This article was originally published here Cell Death Dis. 2022 Mar 25;13(3):269. doi: 10.1038/s41419-022-04664-5. ABSTRACT Stimulator of interferon genes (STING) contributes to immune responses against tumors and may control viral infection including SARS-CoV-2 infection. However, activation of the STING pathway by airway silica or smoke exposure leads to cell death,…

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Got my results . curious about the mtdna haplogroup not being eroupean orgin? : 23andme

I wonder how common Bolivian users are in 23andMe and the impact for making it rare. I’m C1b4 from the Caribbean and it’s also fairly uncommon amongst 23andMe, though C maternal haplogroup is common in my Puerto Rican matches. Edit: If you trace your line directly via your mom’s line…

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Wuhan University Song Zhiyin and other teams discovered a new mechanism of mitochondrial DNA release

Sam50 is a key component of the sorting and assembly machinery (SAM) complex and is also involved in bridging mitochondrial outer and inner membrane contacts. However, the physiological and pathological functions of Sam50 remain largely unknown. On March 21, 2022, Wuhan University Song Zhiyin and Meng Qingtao jointly published a…

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Exercise 13: Mitochondrial DNA (mtDNA) Analysis

Mitochondrial DNA (mtDNA) typing is increasingly used in human identity testing when biological evidence may be degraded, when quantities of the samples in question are limited, or when nuclear DNA typing is not an option. Forensically relevant biological sources of mtDNA include, but are not limited to, hairs, bones, and…

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Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury

doi: 10.3389/fnmol.2022.852243. eCollection 2022. Lauren E Fritsch  1 , Jing Ju  2 , Erwin Kristobal Gudenschwager Basso  3 , Eman Soliman  3 , Swagatika Paul  4 , Jiang Chen  2 , Alexandra M Kaloss  3 , Elizabeth A Kowalski  3 , Taylor C Tuhy  5 , Rachana Deven Somaiya  1 , Xia Wang  3 , Irving Coy Allen  3 , Michelle H…

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Enhanced cGAS-STING-dependent interferon signaling associated with mutations in ATAD3A

dc.identifier.citation Lepelley , A , Della Mina , E , Van Nieuwenhove , E , Waumans , L , Fraitag , S , Rice , G I , Dhir , A , Fremond , M-L , Rodero , M P , Seabra , L , Carter , E , Bodemer…

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Mitochondrial DNA Sequencing | AlphaBiolabs UK

Why choose mitochondrial DNA analysis? Mitochondria contains an independent, circular genome, 16,569 base pairs in length, including a non-coding control region of approximately 1160 base pairs. Each eukaryotic cell contains 100-10,000 copies of mitochondrial DNA (mtDNA), a much higher copy number in comparison to nuclear DNA; this high copy number means…

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Genetic diversity of common carp (Cyprinus carpio L.) strains breed in Poland based on microsatellite, AFLP, and mtDNA genotype data.

Abstract Abstract The common carp (Cyprinus carpio L.) has a long-standing history in Polish pond aquaculture, which has given rise to a great number of local breeds, strains and hatchery populations. They are well adapted to their local conditions, play an important role for fisherman’s livelihoods and…

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Mechanisms involved in the transmission of genetic diseases from mother to child

Mitochondria are the organelles that produce most of the chemical energy needed by the cell. Mitochondrial DNA (mtDNA) contains 16,569 nucleotides that can be mutated. Some of these mutations can lead to the development of mitochondrial diseases. While nuclear DNA (the well-known double helix, which encodes most of the genome)…

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Research reveals mechanism involved in transm

image: Immature mouse egg at a stage prior to ovulation, with mitochondria stained red view more  Credit: Marcos Roberto Chiaratti A research article published in the journal Science Advances describes a mechanism that helps explain how certain kinds of genetic disorders known as mitochondrial diseases are transmitted from mother to child. The study it reports…

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The Clam Cyclina sinensis (Gmelin) Phylogeography Study with 28S rRNA Gene and Potential of Nuclear rRNA Genes in Genetic Assessments of Molluscs

Avise, J. C., 2009. Phylogeography: Retrospect and prospect. Journal of Biogeography, 36: 3–15. Article  Google Scholar  Beheregaray, L. B., 2008. Twenty years of phylogeography: The state of the field and the challenges for the Southern Hemisphere. Molecular Ecology, 17: 3754–3774. Google Scholar  Clement, M., Posada, D., and Crandall, K. A.,…

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Autophagy deficiency abolishes liver mitochondrial DNA segregation

Mutations in the mitochondrial genome (mtDNA) are ubiquitous in humans and can lead to a broad spectrum of disorders. However, due to the presence of multiple mtDNA molecules in the cell, co-existence of mutant and wild-type mtDNAs (termed heteroplasmy) can mask disease phenotype unless a threshold of mutant molecules is…

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BSCI 207 Unit 1 Exam Practice Problems.pdf – Unit 1 Exam Practice Problems 1) Correctly rank the rate of change for mtDNA, nuclear DNA, and rRNA where

Unit 1 Exam Practice Problems1)Correctly rank the rate of change for mtDNA, nuclear DNA, and rRNA where theleftmost term changes the quickest, while the rightmost term changes the slowesta.Nuclear DNA, mtDNA, rRNAb.mtDNA, nuclear DNA, rRNAc.mtDNA, rRNA, nuclear DNAd.rRNA, mtDNA, nuclear DNA 2)If a reaction was spontaneous, which of the following…

Continue Reading BSCI 207 Unit 1 Exam Practice Problems.pdf – Unit 1 Exam Practice Problems 1) Correctly rank the rate of change for mtDNA, nuclear DNA, and rRNA where

Dissertations.se: INITIATION OF DNA REPLICATION

Showing result 1 – 5 of 43 swedish dissertations containing the words initiation of DNA replication. Author : Elisabeth Jemt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; mtDNA; DNA replication; Abstract : Mitochondria produce most of the adenosine triphosphate required in a eukaryotic cell and…

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Scientific Seminar – ONLINE SEMINAR

Scientific Seminar – ONLINE SEMINAR Date: Feb 18, 2022 Time: 13:00 c.t. – 14:00 Speaker: Laura Kremer Karolinska Institutet, Stockholm, Schweden Location: Max-Planck-Institut für Multidisziplinäre Naturwissenschaften (MPI-NAT, Faßberg-Campus) Room: Zoom Host: Ursula Fünfschilling Contact: fuenfschilling@mpinat.mpg.de In 1865 Gregor Mendel discovered the principles of nuclear genetics. More than 150 years later,…

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Haplogroup L3 (mtDNA) – Wikipedia @ WordDisk

Haplogroup L3 is a human mitochondrial DNA (mtDNA) haplogroup. The clade has played a pivotal role in the early dispersal of anatomically modern humans. Widespread human mitochondrial DNA grouping indicating common ancestry Haplogroup L3 Possible time of origin 80,000–60,000 YBP[1] Possible place of origin East Africa[2][3][4] or Asia[5] Ancestor L3’4…

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Mitochondrial DNA content reduction in the most fertile spermatozoa is accompanied by increased mitochondrial DNA rearrangement

Study question: Is there an association between male fertility and spermatozoa mitochondrial DNA (mtDNA) copy number and genome rearrangements? Summary answer: Normal spermatozoa not only have a lower mtDNA copy number but also more DNA rearrangements than spermatozoa of men with severe oligoasthenospermia (SOA). What is known already: While there…

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The cGAS-STING signaling in cardiovascular and metabolic diseases: Future novel target option for pharmacotherapy

Abstract The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling exert essential regulatory function in microbial-and onco-immunology through the induction of cytokines, primarily type I interferons. Recently, the aberrant and deranged signaling of the cGAS-STING axis is closely implicated in multiple sterile inflammatory diseases, including heart failure, myocardial infarction,…

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The fate of damaged mitochondrial DNA in the cell

Available online 5 February 2022, 119233 doi.org/10.1016/j.bbamcr.2022.119233Get rights and content Highlights • Mitochondrial DNA (mtDNA) is a key component of mitochondrion and essential for maintaining mitochondrial function. • mtDNA damage leads to mitochondrial dysfunction and is related to the occurrence of mitochondrial diseases. • Upon mtDNA damage, cell has multiple…

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Library Event Calendar | City of Palm Springs

Making YDNA and mtDNA Part of Your Family History     This Zoom event is presented by the Palm Springs Genealogical Society with guest speaker Diana Southard. After getting bitten by the DNA bug as a high school student, Diana went on to study at Brigham Young University where she earned…

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Mitochondrial DNA variation across 56,434 individuals in gnomAD

Genomic databases of allele frequency are extremely helpful for evaluating clinical variants of unknown significance; however, until now, databases such as the Genome Aggregation Database (gnomAD) have focused on nuclear DNA and have ignored the mitochondrial genome (mtDNA). Here we present a pipeline to call mtDNA variants that addresses three…

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DNA Labs International Launches the Newest Technology for Forensic Genetic Genealogy

MiSeq FGx platform by Verogen DEERFIELD BEACH, Fla. (PRWEB) January 26, 2022 DNA Labs International, which specializes in forensic DNA analysis including forensic genetic genealogy (FGG) for law enforcement agencies, government forensic labs, and attorneys, is announcing the release of their newest technology, Single Nucleotide Polymorphism (SNP) testing with…

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Comprehensive summary of mitochondrial DNA alterations in the postmortem human brain: A systematic review

Summary Background Mitochondrial DNA (mtDNA) encodes 37 genes necessary for synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA alterations are known to cause mitochondrial disease (MitD), a clinically heterogeneous group of disorders that often present with neuropsychiatric symptoms. Understanding the nature and frequency of mtDNA alterations in health…

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Avian mtDNA primers

Avian mtDNA Primers The PDF file below provides details on a complete set of primers for amplifying and sequencing avian mitochondrial DNA. All of the primers have been designed to work with most or all birds and most perform very well in this regard. The document is intended as a…

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A Study on Polymorphism of Mitochondrial DNA (mtDNA) in Populations of D.virilis Distributing in Chinese Continent

JIA Zhen-yu, ZHU Ding-liang, GENG Zhen-cheng, T.Aotsuka. A Study on Polymorphism of Mitochondrial DNA (mtDNA) in Populations of D.virilis Distributing in Chinese Continent. Zoological Research, 1995, 16(1): 65-73. Citation: JIA Zhen-yu, ZHU Ding-liang, GENG Zhen-cheng, T.Aotsuka. A Study on Polymorphism of Mitochondrial DNA (mtDNA) in…

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Why is mtDNA maternal only? : explainlikeimfive

Mitochondria are kind of like an in-between of cell-organelles and bacteria that live in your cells. They are not made by your cells, but they replicate on their own (by splitting in two). For this, they use their own DNA (the mtDNA), not the DNA of your cells. When an…

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GWAS and ExWAS of blood Mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

Background: Mitochondrial DNA copy number (mtDNA-CN) is an accessible blood-based measurement believed to capture underlying mitochondrial function. The specific biological processes underpinning its regulation, and whether those processes are causative for disease, is an area of active investigation. Methods: We developed a novel method for array-based mtDNA-CN estimation suitable for…

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Genetic diversity and selection in Puerto Rican horses

Horses have been considered one of our most prized possessions, used for travel, work, food, and pleasure for at least five and a half millennia17,18,19,20. Nevertheless, the ancestry of various horse breeds and their characteristic traits remains unclear21. In this paper, we describe the patterns and the origins of genetic…

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Estimating individual mtDNA haplotypes in mixed DNA samples by combining MinION and MiSeq

doi: 10.1007/s00414-021-02763-0. Online ahead of print. Affiliations Expand Affiliations 1 Department of Forensic Medicine, Juntendo University School of Medicine, 2-1-1, Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan. hnakani@juntendo.ac.jp. 2 Department of Forensic Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Saitama, 350-0495, Japan. 3 Department of Forensic Medicine, Juntendo University School of Medicine,…

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Global mtDNA Databasing Project | National Institute of Justice

Global mtDNA Databasing Project: AFDIL intends to greatly increase the size and quality of global forensic mtDNA databases openly available to the forensic practitioner community. Using a proven system for high throughput, robotic sequencing, AFDIL will sequence the entire mtDNA control region (CR) of 7,500 target individuals, over a two…

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DNA in Unlikely Places Helps Piece Together Ancient Humans’ Family Trees

This story was originally published in our January/February 2022 issue. Click here to subscribe to read more stories like this one. One hundred thousand years ago, Neanderthals gathered in a cave perched 3,000 feet up in present-day Spain’s Atapuerca Mountains. While cooking and watching youngsters wrestle, they littered the floor with DNA…

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Radboud University Medical Center Increases HiFi Sequencing Capacity with PacBio’s Sequel IIe

Added whole genome sequencing capacity enables the SOLVE-RD research program to significantly increase sample throughput MENLO PARK, Calif., Jan. 07, 2022 (GLOBE NEWSWIRE) — PacBio (Nasdaq: PACB), a leading developer of high-quality, highly accurate sequencing platforms, today announced Radboud University Medical Center (Radboudumc) in Nijmegen, the Netherlands will increase their…

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Genetic diagnosis of basal ganglia disease in childhood

This article was originally published here Dev Med Child Neurol. 2022 Jan 5. doi: 10.1111/dmcn.15125. Online ahead of print. ABSTRACT AIM: To correlate clinical, radiological, and biochemical features with genetic findings in children with bilateral basal ganglia lesions of unknown aetiology, and propose a diagnostic algorithm for early recognition. METHOD:…

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Human Mitochondrial Genome Feature Table for GenBank BankIt

Human Mitochondrial Genome Feature Table for GenBank BankIt 0 Hello Bioinfo Stars, I would like to submit human mitochondrial genome sequences to GenBank using BankIt portal, but encountered problem with the preparation of the five column Feature Table. As you may know, Feature Table for mitochondrial genomes of Metazoa (i.e….

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Dissertations.se: MITOCHONDRIAL CARDIOMYOPATHY

Showing result 1 – 5 of 9 swedish dissertations containing the words mitochondrial cardiomyopathy. Author : Gittan Kollberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Energy metabolism; Mitochondrial Disorders; mtDNA; multiple mtDNA deletions; Alpers-Huttenlocher syndrome; POLG1; GYS1; glycogen synthase; point mutation; Polymerase…

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Haplogroup M (mtDNA)

In human genetics, Haplogroup M is a human mitochondrial DNA (mtDNA) haplogroup. An enormous haplogroup spanning many continents, the macro-haplogroup M is a branch of the haplogroup L3. M is believed to have originated in Asia [Gonzalez et al., [www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1945034 Mitochondrial lineage M1 traces an early human backflow to Africa]…

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Publication A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA.

Your browser does not have JavaScript enabled. Some parts of this website may require JavaScript to function correctly First Author  Hashizume O Year  2015 Journal  PLoS One Volume  10 Issue  3 Pages  e0118561 PubMed ID  25738506 Mgi Jnum  J:233444 Mgi Id  MGI:5784636 Doi  10.1371/journal.pone.0118561 Citation  Hashizume O, et al. (2015)…

Continue Reading Publication A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA.

Non-random tissue distribution of mutant mtDNA – ePrints

Non-random tissue distribution of mutant mtDNA Lookup NU author(s): Professor Patrick Chinnery, Professor Mark Walker, Professor Robert Taylor, Professor Robert Lightowlers, Professor Laurence Bindoff, Emeritus Professor Doug Turnbull Downloads Full text for this publication is not currently held within this repository. Alternative links…

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Which best describes mitochondrial dna (mtdna)?

Mitochondrial DNA of human cells only encodes for a small percentage of proteins that function in mitochondria 3. This pedigree describes the inheritance of a mutation that affects mitochondria function. Which of the proteins below is most likely affected by this mutation? Please note: circles refer to females, squares refer…

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Nuclear Genome-Encoded Long Noncoding RNAs and Mitochondrial Damage in Diabetic Retinopathy

. 2021 Nov 23;10(12):3271. doi: 10.3390/cells10123271. Affiliations Expand Affiliations 1 Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University, Detroit, MI 48201, USA. 2 Kresge Eye Institute, 4717 St. Antoine, Detroit, MI 48201, USA. Item in Clipboard Ghulam Mohammad et al. Cells. 2021. Show details Display options Display options Format…

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mtDNA Brick Wall in 1773 NH – can anyone help identify parents?

I could really use the help of an expert New England genealogist to break through a long-standing mtDNA brick wall.  Our mtDNA results could be very helpful to others if we can push our maternal line back a few more generations. My direct maternal-line fourth-great-grandmother, [[Johnson-99341|Sarah (Johnson) Haven (1773-1836)]], was born…

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Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus

Objectives: Cell-free DNA is involved in the pathogenesis of systemic lupus erythematosus (SLE) but the clinical value of cell-free DNA measurements in SLE is unknown. Our aim was therefore to examine the utility of mitochondrial (mt) DNA and nuclear (n) DNA quantification in SLE. Methods: EDTA plasma was drawn from…

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mtDNA : reconstructingjudaism

Shalom!Long story coming. Long story short. Found that i might be having Jewish ancestry. After many commercial DNA kits found nothing (it must be mentioned that most kits show you 200 to 300 years ago, in some cases 500 years ago). I have done a mtDNA test from Family Tree…

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Haplogroup L4 (mtDNA) explained

L4 Origin-Date: 90 – 80 kya Origin-Place: East Africa Ancestor: L3’4 Mutations: 5460, 16362[1] Haplogroup L4 is a human mitochondrial DNA (mtDNA) haplogroup. It is a small maternal clade primarily restricted to Africa.[2] L4 is important in East Africa and Horn of Africa. The highest frequencies are in Tanzania among the…

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Frontiers | The cGAS-STING Pathway: A Promising Immunotherapy Target

Introduction Invaded by exogenous or endogenous pathogens, the host immune system will be activated accordingly to resist harm and maintain homeostasis, which includes innate immunity and adaptive immunity. As the first line of host immune defense, innate immunity plays a critical role in recognizing extracellular and intracellular pathogens (1, 2)….

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Role Of Mitochondrial DNA Copy Number In Incident Cardiovascular Diseases And The Association Between Cardiovascular Disease And Type 2 Diabetes: A Follow-up Study On Middle-aged Women

Atherosclerosis. 2021 Dec 1:S0021-9150(21)01448-9. doi: 10.1016/j.atherosclerosis.2021.11.020. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Mitochondrial DNA copy number (mtDNA-CN) is a surrogate biomarker of mitochondrial dysfunction and is associated with type 2 diabetes (T2D) and cardiovascular disease (CVD). However, despite being associated with both CVD and T2D, it is not known what…

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Mitochondrial DNA Copy Number as a Marker and Mediator of Stroke Prognosis: Observational and Mendelian Randomization Analyses

Background: Low buffy coat mitochondrial DNA copy number (mtDNA-CN) is associated with incident risk of stroke and post-stroke mortality; however, its prognostic utility has not been extensively explored. Objective: To investigate whether low buffy coat mtDNA-CN is a marker and causal determinant of post-stroke outcomes using epidemiological and genetic studies….

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Mitochondrial mutations in Caenorhabditis elegans show signatures of oxidative damage and an AT-bias

. 2021 Oct 2;219(2):iyab116. doi: 10.1093/genetics/iyab116. Affiliations Expand Affiliations 1 Department of Biology, Colorado State University, Fort Collins, CO 80523, USA and. 2 Department of Integrative Biology, University of Texas at Austin, Austin, TX 78712, USA. Item in Clipboard Gus Waneka et al. Genetics. 2021. Show details Display options Display options…

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How is mitochondrial DNA (mtDNA) typing used in forensic science? a) A suspect’s mtDNA sample is

Suggest how coeliac disease could affect the growth of a child A solution has a pH of 2. Which best describes the solution? …answer: a strong acid What is the difference between a population and a community? Multiple choice question. cross out A) A population is made up of all…

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MitoVisualize: A resource for analysis of variants in human mitochondrial RNAs and DNA

Abstract We present MitoVisualize, a new tool for analysis of the human mitochondrial DNA (mtDNA). MitoVisualize enables visualization of: (1) the position and effect of variants in mitochondrial transfer RNA (tRNA) and ribosomal RNA (rRNA) secondary structures alongside curated variant annotations, (2) data across RNA structures, such as to show…

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Parallel genomic responses to historical climate change and high elevation in East Asian songbirds

Extreme environments present profound physiological stress. The adaptation of closely related species to these environments is likely to invoke congruent genetic responses resulting in similar physiological and/or morphological adaptations, a process termed “parallel evolution” (1). Existing evidence shows that parallel evolution is more common at the phenotypic level than at…

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[ASAP] Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis

Published in Journal of the American Chemical Society, American Chemical Society Content Journal of the American Chemical Society DOI: 10.1021/jacs.1c08860 Xiu-Cai Chen, Gui-Xue Tang, Wen-Hua Luo, Wen Shao, Jing Dai, Shu-Tang Zeng, Zhi-Shu Huang, Shuo-Bin Chen, and Jia-Heng Tan At Life Science Network we import abstract of articles published in…

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Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis

The mitochondrial DNA G-quadruplex (mtDNA G4) is a potential regulatory element for the regulation of mitochondrial functions; however, its relevance and specific roles in diseases remain largely unknown. Here, we engineered a set of chemical probes, including MitoISCH, an mtDNA G4-specific fluorescent probe, together with MitoPDS, a mitochondria-targeted G4-stabilizing agent,…

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Primate mtDNA Phylogeny – no web search (fall 2021).docx – PRIMATE PHYLOGENY LAB Goal By the end of this lab you should be able to Recognize the

PRIMATE PHYLOGENY LAB Goal: By the end of this lab, you should be able to:  Recognize the composition of a character data matrix produced from a set of aligned sequences.  Recognize that the most parsimonious tree has the fewest steps.  Trace the evolution of a character on…

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Homicide Victim Found on Fire Island in 1989 Identified by DNA Analysis and Genetic Genealogy

Michael Bevers 1978. Image-state of Alaska December 1, 2021 (Anchorage, AK) – On July 24th, 1989, human remains were found on the northwest shore of Fire Island, west of Anchorage.  Investigators from the Alaska State Troopers (AST) responded to the scene and collected the remains.  An autopsy concluded that the…

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Mitochondrial DNA copy number, metabolic syndrome, and insulin sensitivity: Insights from the Sugar, Hypertension, and Physical Exercise Studies

Abstract Mitochondrial DNA copy number (mtDNA-CN) measured in blood has been associated with many aging-related diseases, with higher mtDNA-CN typically associated with lower disease risk. Exercise training is an excellent preventative tool against aging-related disorders and has been shown to increase mitochondrial function in muscle. Using the Sugar, Hypertension, and…

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Creative Biogene: The Premier Integrated Mitoepigenetics Services Provider

Creative Biogene declared the release of its integrated mitoepigenetics services for worldwide clients. New York, USA – November 30, 2021 – As a pioneering biotech company engaged in mitochondrial research, Creative Biogene focuses on providing high-quality mitochondrial products and services, as well as proprietary technology to boost the research in…

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Mitochondrial DNA haplogroup R predicts survival advantage in severe sepsis in the Han population

doi.org/10.1097/GIM.0b013e318163c343Get rights and content Abstract Purpose To determine whether the main mitochondrial DNA (mtDNA) haplogroups of the Han people have an impact on long-term clinical outcome. Methods We prospectively studied 181 individuals who were sequentially admitted to the intensive care unit. Demographic and clinical data were recorded along with clinical…

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Effects of caloric restriction and aerobic exercise on circulating cell-free mitochondrial DNA in patients with moderate-to-severe chronic kidney disease

Circulating cell-free mitochondrial DNA (ccf-mtDNA) may induce systemic inflammation, a common condition chronic kidney disease (CKD), by acting as a damaged-associated molecular pattern. We hypothesized that in patients with moderate to severe CKD, aerobic exercise would reduce ccf-mtDNA levels. We performed a post hoc analysis of a multicenter randomized trial…

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Genetic genealogy research – Boteap.com

The completion of the human genome sequencing project was the first step in allowing scientists to unravel the secrets contained in our DNA. Also, in recent years, DNA testing has become affordable and easy to do. This has led to the practice of conducting DNA testing for genealogical purposes, which…

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Application of a West Eurasian-Specific Filter for Quasi-Median Network Analysis: Sharpening the Blade for mtDNA Error Detection

Abstract The application of quasi-median networks provides an effective tool to check the quality of mtDNA data. Filtering of highly recurrent mutations prior to network analysis is required to simplify the data set and reduce the complexity of the network. The phylogenetic background determines those mutations that need to be…

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GHEP-EMPOP Collaboration on mtDNA Population DataA New Resource for Forensic Casework

Abstract Mitochondrial DNA (mtDNA) population data for forensic purposes are still scarce for some populations, which may limit the evaluation of forensic evidence especially when the rarity of a haplotype needs to be determined in a database search. In order to improve the collection of mtDNA lineages from the Iberian…

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The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection | BMC Genomic Data

1. Taylor RW, Turnbull DM. Mitochondrial DNA mutations in human disease [Internet]. Vol. 6, Nature Reviews Genetics. Europe PMC Funders; 2005 [cited 2020 Aug 21]. p. 389–402. Available from: /pmc/articles/PMC1762815/?report=abstract. 2. Kabunga P, Lau AK, Phan K, Puranik R, Liang C, Davis RL, Sue CM, Sy RW Systematic review of…

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CD Genomics Offers NGS Services for Mitochondrial Research

New York, USA – November 26, 2021 – CD Genomics is one of the top genomics service providers in genomic research, dedicated to providing reliable services to pharmaceutical and biotech companies as well as academia and government agencies. With its high-throughput sequencing platforms, CD Genomics can provide solutions for a…

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The earliest Denisovans and their cultural adaptation

1. Reich, D. et al. Genetic history of an archaic hominin group from Denisova Cave in Siberia. Nature 468, 1053–1060 (2010). CAS  PubMed  PubMed Central  Google Scholar  2. Krause, J. et al. The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature 464, 894–897 (2010). CAS  PubMed …

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Rewiring cell signalling pathways in pathogenic mtDNA mutations

doi.org/10.1016/j.tcb.2021.10.005Get rights and content Highlights Mutations of mitochondrial DNA (mtDNA) cause disease with a wide range of presentations and severity. The relationships between genotype and phenotype are not understood. Mitochondrial heteroplasmy is the presence of more than one type of mitochondrial DNA within cells and tissues: notably mtDNA with a…

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Haplogroup L1 (mtDNA) | Familypedia

In human genetics, Haplogroup L1 is a human mitochondrial DNA (mtDNA) haplogroup. Haplogroup L1 is found in West and Central sub-Saharan Africa. Some of its branches (L1d, L1k, L1a, L1f) were recently re-classified into haplogroup L0 as L0d, L0k, L0a and L0f. Haplogroup L1 arose with Mitochondrial Eve and haplogroup…

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Haplogroup N (mtDNA) | Familypedia

Haplogroup N Possible time of origin unknown, approx. 80000 years ago Possible place of origin Africa Ancestor L3 Descendants N1, A, I, W, R, X Defining mutations 73, 7028, 11719, 12705, 14766, 16223 In human genetics, Haplogroup N is a human mitochondrial DNA (mtDNA) haplogroup. An enormous haplogroup spanning many…

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Vincent Procaccio – Academia.edu

Vincent Procaccio – Academia.edu Academia.edu no longer supports Internet Explorer. To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser. Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our…

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Herpes Simplex Virus Type 1 Infection Disturbs the Mitochondrial Network, Leading to Type I Interferon Production through the RNA Polymerase III/RIG-I Pathway

Viruses have evolved a plethora of mechanisms to impair host innate immune responses. Herpes simplex virus type 1 (HSV-1), a double-stranded linear DNA virus, impairs the mitochondrial network and dynamics predominantly through the UL12.5 gene. We demonstrated that HSV-1 infection induced a remodeling of mitochondrial shape, resulting in a fragmentation…

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“Evaluating Bioenergetics and Mitochondrial Dynamics in Patient Fibrobl” by Ajibola Bakare

Degree Name Doctor of Philosophy in Cell & Molecular Biology (PhD) Keywords Cellular respiration, Leigh syndrome, Mitchondrial respiration, Mitochondria, Mitochondrial dynamics, Pathogenic mitochondrial DNA mutation Abstract Leigh syndrome (LS) is a rare fatal mitochondrial disorder of infants caused by pathogenic mutations in the nuclear (nDNA) or mitochondrial DNA (mtDNA) leading…

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