Tag: mtDNA

Mitochondrial genes – TPM calculation bulk RNA-Seq

Mitochondrial genes – TPM calculation bulk RNA-Seq 0 Hello all, I was wondering if any of you have encountered a situation for bulk RNA-Seq where, possibly due to low sample quality or presence of dead cells, mitochondrial genes are expressed to a very large degree relative to other genes, thus…

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New molecule extends lifespan and boosts muscle function

Buck Institute researchers identify new pathway for mitophagy which highlights the gut/brain connection. Researchers at the Buck Institute for Research on Aging have identified a new drug-like molecule that keeps mitochondria healthy via mitophagy, a process that removes and recycles damaged mitochondria in multicellular organisms. The compound, dubbed MIC, is…

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Impact of N221S missense mutation in human ribonucleotide reductase small subunit b on mitochondrial DNA depletion syndrome

hRRM2B mutagenesis study The fatal consequences of N221S mutation7 led to a thorough investigation of the impacts of N221 side chain, a conserved residue in RNR small subunit. Site-directed mutagenesis studies involving six N221 constructs were performed to elucidate the molecular mechanism of N221S related MDDS. The mutations were designed…

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Dryad | Data — DNA sequence data generated using non-invasive feather and eggshell samples from the Grenada Dove for two gene regions: Cyt b and ND2

As an island endemic with a decreasing population, the Critically Endangered Grenada Dove Leptotila wellsi is threatened by accelerated loss of genetic diversity resulting from ongoing habitat fragmentation. Small, threatened populations are difficult to sample directly but advances in molecular methods mean that non-invasive samples can be used. We performed…

Continue Reading Dryad | Data — DNA sequence data generated using non-invasive feather and eggshell samples from the Grenada Dove for two gene regions: Cyt b and ND2

Operation 85: U.S.S. Arizona Family Members Cross Halfway Point in Identifying Commingled Unknowns

Executive Director of Operation 85 and grandnephew of a USS Arizona missing sailor has spent over $25 thousand dollars and worked the past 7 months to identify the USS Arizona unknowns with tremendous results so far, yet very little support from the DPAA. GM2c Robert Edwin Kline poses outside the…

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Reneo Pharmaceuticals Reports Third Quarter 2023 Financial

IRVINE, Calif., Nov. 13, 2023 (GLOBE NEWSWIRE) — Reneo Pharmaceuticals, Inc. (Nasdaq: RPHM), a clinical-stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, today reported financial results for the third quarter ended September 30, 2023 and provided a business update. “We…

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Solved: Chapter DNA Problem 6RQ Solution | Concepts Of Genetics, Books A La Carte Plus Mastering Genetics With Pearson Etext — Access Card Package 12th Edition

Mitochondrial DNA (mtDNA) profiling is an analytical technique where DNA regions present in mitochondria are analyzed. Hypervariable segment I and II are the most commonly amplified regions that are utilized in mitochondrial DNA (mtDNA) profiling. The mtDNA are amplified by Polymerase Chain Reaction. Amplified fragments are then sequenced by automated…

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Disproportionate role of nuclear-encoded proteins in organismal and mitochondrial thermal performance in a copepod

. 2023 Nov 10:jeb.246085. doi: 10.1242/jeb.246085. Online ahead of print. Affiliations Expand Affiliation 1 Department of Integrative Biology, Oregon State University, Corvallis, OR 97331, USA. Item in Clipboard Kamron L Kayhani et al. J Exp Biol. 2023. Show details Display options Display options Format AbstractPubMedPMID . 2023 Nov 10:jeb.246085. doi: 10.1242/jeb.246085….

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MY FAMILY WEBPAGE

MY FAMILY WEBPAGE As you can see by the information displayed on this website, I have been able to trace our ancestry back several generations, to the early 1800’s. On…

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Mitochondrial DNA Sequencing and Heteroplasmy Quantification by Next Generation Sequencing

Over the last 10 years, next generation sequencing (NGS) became the gold standard for both diagnosis and discovery of new disease genes responsible for heterogeneous disorders, such as mitochondrial encephalomyopathies. The application of this  …more Over the last 10 years, next generation sequencing (NGS) became the gold standard for both diagnosis and…

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Ginsenoside Rg3 enriches SCFA-producing commensal bacteria to confer protection against enteric viral infection via the cGAS-STING-type I IFN axis

Rg3 elicits protection against local and systemic enteric virus infection by regulating the intestinal microbiome To assess the antiviral effects of Rg3 in vivo, groups of C57BL/6J mice (referred to as WT B6 hereafter) were orally administered Rg3 for 3 consecutive days, inoculated with MNV-1 by the peroral route, and…

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Unraveling the Genetic Story of a Woolly Rhinoceros

Fossilized feces, or coprolites, have proven to be a goldmine of information about ancient species. In a groundbreaking discovery, scientists have successfully extracted mitochondrial DNA from coprolites dating back to the Pleistocene epoch. This breakthrough has unveiled the genetic story of a previously unexplored species—the woolly rhinoceros. Unlike traditional methods…

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How mitochondrial DNA exchange alter metabolic pathways?

Who said this: magnetic fields “can change the mitochondria in cells and enhance plant metabolism? 3 answers What pathway does mitochondrial dysfunction trigger to induce chondrocyte apoptosis? 5 answers What is physiological process oft mitochondrial biogenesis through estrogen? 5 answers Does physical inactivity affect the mitochondrial metabolism? 5 answers What…

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Two sympatric lineages of Australian Cnestus solidus share Ambrosiella symbionts but not Wolbachia

Andersen HF, Jordal BH, Kambestad M, Kirkendall LR (2012) Improbable but true: the invasive inbreeding ambrosia beetle Xylosandrus morigerus has generalist genotypes. Ecol Evol 2:247–257 Article  PubMed  PubMed Central  Google Scholar  Arif S, Gerth M, Hone‐Millard WG, Nunes MDS, Dapporto L, Shreeve TG (2021) Evidence for multiple colonisations and Wolbachia…

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In silico prospecting of the mtDNA of Macrobrachium amazonicum from transcriptome data | BMC Genomics

Bentes B, Martinelli J, Souza L, Cavalcante D, Almeida M, Isaac V. Spatial distribution of the amazon river prawn Macrobrachium Amazonicum (Heller, 1862) (Decapoda, Caridea, Palaemonidae) in two perennial creeks of an estuary on the northern coast of Brazil (Guajará Bay, Belém, Pará). Brazilian J Biol. 2011;71:925–35. Article  Google Scholar …

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Apoptotic stress causes mtDNA release during senescence and drives the SASP – ePrints

Apoptotic stress causes mtDNA release during senescence and drives the SASP Lookup NU author(s): Hanna Salmonowicz, Dr James ChapmanORCiD, George Kelly, Dr Laura Greaves, Professor Derek Mann, Dr Viktor Korolchuk Downloads Full text for this publication is not currently held within this repository….

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best annotator for mitochondria and heteroplasmy calculation

best annotator for mitochondria and heteroplasmy calculation 0 Dear all, I am analysing sequencing data on mitochondrial DNA with the aim of finding pathogenic variants. I only have the vcf’s. Does anyone have any suggestions as to where I can annotate them? Unfortunately Annovar doesn’t annotate anything for me and…

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DUSP1 protects against ischemic acute kidney injury through stabilizing mtDNA via interaction with JNK

The mechanism underlying acute kidney injury (AKI) and AKI-to-Chronic kidney disease (CKD) transition remains unclear, but mitochondrial dysfunction may be a key driving factor. Literature reports suggest that dual-specificity phosphatase 1 (DUSP1) plays a critical role in maintaining mitochondrial function and structural integrity. In this study, ischemic Acute Kidney Injury…

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Solved Most modern historians agree that Thomas Jefferson

Most modern historians agree that Thomas Jefferson fathered children with his slave, Sally Hemings. This claim is supported by DNA evidence, although the evidence cannot rule out that another male member of the Jefferson family was actually the father of Hemings’ children. Assuming Jefferson was the father of Sally Hemings’…

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Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders | Molecular Neurodegeneration

Hemmi H, et al. A toll-like receptor recognizes bacterial DNA. Nature. 2000;408(6813):740–5. Article  CAS  PubMed  Google Scholar  Unterholzner L, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010;11(11):997–1004. Article  CAS  PubMed  PubMed Central  Google Scholar  Chiu YH, Macmillan JB, Chen ZJ. RNA polymerase III detects…

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3 Key Updates in Parkinson’s Disease

Clinical Relevance: There are some promising new developments in Parkinson’s A new study has identified mitochondrial DNA damage as a potential root cause of Parkinson’s. A new “neuroprosthetic” has enabled a patient who was diagnosed with Parkinson’s 30 years ago to walk normally. A glove modeled after the suspension mechanism…

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The power and potential of mitochondria transfer

Roger, A. J., Muñoz-Gómez, S. A. & Kamikawa, R. The origin and diversification of mitochondria. Curr. Biol. 27, R1177–R1192 (2017). Article  CAS  PubMed  Google Scholar  Monzel, A. S., Enríquez, J. A. & Picard, M. Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction. Nat. Metab. 5, 546–562 (2023). Article  PubMed …

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Linking of oxidative stress and mitochondrial DNA damage to the pathophysiology of idiopathic intrauterine growth restriction

Objective: A common and serious pregnancy issue known as intrauterine growth restriction (IUGR) occurs when the fetus is unable to reach its full growth potential. Mitochondria are crucial to the development of the fetus and the placenta. We aimed to elucidate the role of oxidative stress parameters and markers of…

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Solved The first person in the family represented by the

The first person in the family represented by the pedigree shown here who exihibited symptoms of the mitochondrial disease MERRF was II–2. Check all possible explanations of why the mother (I–1) was unaffected but her daughter (II2) was affected. Check All That Apply The father (I–2) was homoplasmic for mutant…

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Can HGT introduce foreign mtDNA into an individual’s mitochondrial genome.

Step 1: Horizontal gene transfer (HGT) can introduce foreign mtDNA into an individual’s mitochondrial genome. This process has been observed in angiosperm plants, where foreign sequences, including those derived from plastids, have been identified in mitochondrial genomes. Additionally, evidence suggests that HGT can occur between parasitic plants and their hosts,…

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How mitochondrial DNA occur? | 3 Answers from Research papers

Step 1: Mitochondrial DNA is essential for cellular respiration and energy production. It is located in nucleoids and encodes proteins necessary for ATP production. Mutations in mtDNA can lead to various diseases, including Alzheimer’s and Parkinson’s. The origin of mitochondrial DNA is proposed to be from the plasmid of an…

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mtDNA data reveal disparate population structures and High Arctic colonization patterns in three intertidal invertebrates with contrasting life history traits

1Institute of Oceanology, Polish Academy of Sciences, Poland 2University of Łódź, Poland 3Marine Biological Association of the United Kingdom, United Kingdom 4University of Liverpool, United Kingdom 5Lomonosov Moscow State University, Russia 6Akvaplan niva AS, Norway 7The…

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Development of mitochondrial gene-editing strategies and their potential applications in mitochondrial hereditary diseases: a review

Review . 2023 Nov 6:S1465-3249(23)01076-9. doi: 10.1016/j.jcyt.2023.10.004. Online ahead of print. Affiliations Expand Affiliations 1 Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, China. 2 The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao University, Qingdao, China. 3 Institute for Translational Medicine, The…

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Genetic analysis and multimodal imaging identify novel mtDNA 12148T>C leading to multisystem dysfunction with tissue-specific heteroplasmy

Abstract Patients with mitochondrial disorders present with clinically diverse symptoms, largely driven by heterogeneous mutations in mitochondrial-encoded and nuclear-encoded mitochondrial genes. These mutations ultimately lead to complex biochemical disorders with a myriad of clinical manifestations, often accumulating during childhood on into adulthood, contributing to life-altering and sometimes fatal events. It…

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File:Principal component analysis (PCA) based on mitochondrial DNA (mtDNA) haplogroup frequencies of ancient and present-day Eurasian populations.png

Summary DescriptionPrincipal component analysis (PCA) based on mitochondrial DNA (mtDNA) haplogroup frequencies of ancient and present-day Eurasian populations.png English: Principal component analysis (PCA) based on mitochondrial DNA (mtDNA) haplogroup frequencies of ancient and present-day Eurasian populations Date 5 November 2023 Source Ancient Mitochondrial Genomes Reveal Extensive Genetic Influence of the…

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Haplotype and phylogenetic diversity using mitochondrial 12S rRNA gene marker in Bali cattle | Suselowati

Haplotype and phylogenetic diversity using mitochondrial 12S rRNA gene marker in Bali cattle T. Suselowati  –  Graduate School of Animal Science Faculty, IPB University, Indonesia R. R. Noor  –  Department of Animal Production and Technology, Faculty of Animal Science, IPB University, Indonesia *J. Jakaria  –  Department of Animal Production and…

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Correction of a homoplasmic mitochondrial tRNA mutation in patient-derived iPSCs via a mitochondrial base editor

Human induced pluripotent stem cells (iPSCs) Reprogramming and Culture This study was ethically approved by the Medical Ethics Committee of Nanjing Maternal and Child Health Care Hospital (2021KY-131), and informed consents were obtained from the patient’s legal guardian as well as the healthy donors, in accordance with the Declaration of…

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Determination of Genetic Structure of Trout Populations Using mtDNA-RFLP Analysis Method in Turkey

Bibtex @ { yunusae235540, journal = {Aquaculture Studies}, issn = {2618-6381}, address = {}, publisher = {Su Ürünleri Merkez Araştırma Enstitüsü}, year = {2006}, volume = {2006}, number = {4}, pages = {0 – 0}, doi = {10.17693/yunus.47858}, title = {Determination of Genetic Structure of Trout Populations Using mtDNA-RFLP Analysis…

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Solved mtDNA depletion syndrome 13 is a rare genetic

Transcribed image text: mtDNA depletion syndrome 13 is a rare genetic disorder, in which individuals have fewer mitochondria in the muscles than normal because the organelles are degraded by lysosomes. Would this disorder impact the muscles’ ability to perform the Cori Cycle? Yes, it would interfere with lactic acid fermentation….

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ANGSD beagle generation returning empty file

ANGSD beagle generation returning empty file 0 Hello Biostars community, I am struggling quite a bit with ANGSD these days as it seems that no code I provide to the machine is working as intended. I want now to produce a beagle file but the following script is returning me…

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Genes | Free Full-Text | Unraveling the Genetic Threads of History: mtDNA HVS-I Analysis Reveals the Ancient Past of the Aburra Valley

1. Introduction The Antioquia region has played a pivotal role in the pre-Hispanic history of South America, serving as a gateway for the initial human migrations to the continent and as a hub for the development of a sophisticated culture deeply rooted in the utilization of natural resources and advanced…

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Mitochondrial DNA And Aging: What’s The Connection?

Mitochondria – microbiology, cellular organelle 3d illustration getty This article is part of a series on recent advances in the science and medicine of longevity. Cells, like us humans, grow old with time. As they do, they begin to secrete inflammatory molecules. A little inflammation is important for wound healing…

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Remains of local Korean War soldier identified 73 years later

Nov. 1—The remains of a Miamisburg soldier killed during the Korean War will be be interred at a Miamisburg cemetery next week. Army Pfc. Billy A. DeBord, a native of Miamisburg, was 18 years old and a member of F Company, 2nd Battalion, 5th Cavalry Regiment, 1st Cavalry Division, Eighth…

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Mitonuclear interactions shape both direct and parental effects of diet on fitness, and involve a SNP in mitoribosomal 16s rRNA

Dobson, A. , Voigt, S., Kumpitsch, L., Langer, L., Voigt, E., Ibrahim, R., Dowling, D. and Reinhardt, K. (2023) Mitonuclear interactions shape both direct and parental effects of diet on fitness, and involve a SNP in mitoribosomal 16s rRNA. PLoS Biology, 21(8), e3002218. (doi: 10.1371/journal.pbio.3002218) (PMID:37603597) (PMCID:PMC10441796) Abstract Nutrition is…

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Solved 1. Suppose you are examining a newly found plant

Transcribed image text: 1. Suppose you are examining a newly found plant species and you want to determine whether the inheritance of mtDNA is maternal, paternal, or biparental. You find that in the population, two variants of mtDNA exist that can be distinguished by size differences of PCR amplification products…

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Dryad | Data — MtDNA genomes from Ranis individuals aligned with previously published ancient & modern humans

The Middle to Upper Palaeolithic transition in Europe is associated with the regional disappearance of Neanderthals and the spread of Homo sapiens. Archaeological evidence indicates the presence of technocomplexes at the interface of this transition, complicating our understanding of the period and the association of those with specific hominin groups….

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Dryad | Data — Mitochondrial DNA from Borsuka Cave

README: Multiple sequence alignment of newly reconstructed and published Human mtDNA: One multiple sequence alignments (MSA) used for tree building and molecular branch shortening for the associated publication. These contain both previously published and newly reconstructed human mtDNA genomes. 1. Aligned_human_mtDNA_Borsuka.fst This MSA is aligned to the revised cambridge reference…

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What is the homology of rRNA between whales and human

The homology of rRNA between whales and humans has been studied in several papers. Arnason et al. found that the mitochondrial DNA (mtDNA) of the fin whale is similar to that of other mammals, including humans, with a high level of similarity in the D-loop region and the rRNA genes….

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How does the homology of rRNA between whales compare to other mammals?

The homology of rRNA between whales and other mammals has been studied in several papers. One study compared the mitochondrial DNA (mtDNA) of the fin whale and other species, and found that the general similarity between the mtDNA of the fin whale and the cow is greater than the similarity…

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Can PCR be performed on embryo spent culture medium?

PCR can be performed on embryo spent culture medium to detect genetic information. Studies have shown that miRNA, such as miR-191-3p, can be detected in the culture media of human embryos and may serve as a molecular marker for assessing embryo competence in a non-invasive way. Additionally, the ratio of…

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MtDNA variation, oxygen and nutrient sensing pathways in the penetrance of mitochondrial disease

  [eng] Mitochondrial diseases (MDs) are metabolic rare disorders impairing the OXPHOS system. mtDNA is polyplasmic, therefore mutant and wild-type alleles can coexist in the same mitochondria or cell in a state known as heteroplasmy. The regulation of heteroplasmy is poorly understood and some nutrient sensing pathways seem to have…

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CIMB | Free Full-Text | mtDNA Single-Nucleotide Variants Associated with Type 2 Diabetes

1. Introduction Type 2 diabetes (T2D) is the most prevalent metabolic disease and a significant public health concern [1,2], leading to early-onset disability and elevated mortality due to various related complications [3]. Between 1990 and 2017, the global trend in the age-standardized rates of T2D, as measured by the number…

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Visualization of mtDNA Using FISH

Proper mitochondrial DNA (mtDNA) levels are critical for many cellular biological functions and are associated with aging and many mitochondria disorders. Defects in core subunits of the mtDNA replication machinery lead to decreased mtDNA levels.  …more Proper mitochondrial DNA (mtDNA) levels are critical for many cellular biological functions and are…

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Developing the Protocol Infrastructure for DNA Sequencing Natural History Collections

Article metadata Introduction Natural history collections as a resource for genomic science Storage and preservation of museum specimens Properties of DNA in natural history collections and implications for sequencing museum specimens Outstanding challenges to the routine sequencing of museum specimens Deciding when it is appropriate to sample museum specimens for…

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Mitochondrial DNA copy number is associated with incident chronic kidney disease and proteinuria in the AIDS linked to the intravenous experience cohort

Chronic Kidney Disease in the United States, 2021. www.cdc.gov/kidneydisease/publications-resources/ckd-national-facts.html. Saran, R. et al. US renal data system 2019 annual data report: Epidemiology of kidney disease in the United States. Am. J. Kidney Dis. 75, A6–A7 (2020). Article  PubMed  Google Scholar  Matsushita, K. et al. Epidemiology and risk of cardiovascular disease…

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After decades as an ‘unknown,’ a WWII soldier from Utah identified

SALT LAKE CITY — A World War II soldier from Duchesne, Utah, has finally, officially, been found.  The family said that U.S. Army Air Force Pvt. Doyle W. Sexton was accounted for in mid-June, 2023. Today, after a full briefing on his identification, his family said they’re ready to tell…

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Temporal analysis of mtDNA variation reveals decreased genetic diversity in least terns

The Least Tern (Sternula antillarum) has undergone large population declines over the last century as a result of direct and indirect anthropogenic factors. The genetic implications of these declines are unknown. We used historical museum specimens (pre-1960) and contemporary (2001–2005) samples to examine range-wide phylogeographic patterns and investigate potential loss…

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High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life.

Authors Angelos Glynos, Lyuba V Bozhilova, Michele Frison, Stephen Burr, James B Stewart, Patrick F Chinnery Published in Science advances. Volume 9. Issue 43. Pages eadi4038. Oct 27, 2023. Epub Oct 25, 2023. Abstract Heteroplasmic mitochondrial DNA (mtDNA) mutations are a major cause of inherited disease and contribute to common…

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New Potential Biomarker for Parkinson’s Disease: A Fresh Perspective

Researchers at Duke University have made an intriguing discovery in their investigation of mitochondrial DNA (mtDNA) as a potential biomarker for Parkinson’s disease. This breakthrough offers a new approach to measuring disease progression and identifying individuals at risk of developing Parkinson’s. Mitochondria, the energy powerhouses of our cells, have their…

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Mitochondrial DNA copy number in Hepatitis C virus-related chronic liver disease: impact of direct-acting antiviral therapy

Thrift, A. P., El-Serag, H. B. & Kanwal, F. Global epidemiology and burden of HCV infection and HCV-related disease. Nat. Rev. Gastroenterol. Hepatol. 14, 122–132 (2017). Article  PubMed  Google Scholar  Madrigal-Matute, J. & Cuervo, A. M. Regulation of liver metabolism by autophagy. Gastroenterology 150, 328–339 (2016). Article  CAS  PubMed  Google…

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A new potential biomarker for Parkinson’s

Researchers at Duke University have recently presented data on a new potential biomarker for Parkinson’s that could be useful in clinical trials targeting the LRRK2 gene in people with Parkinson’s. Human DNA contains all of our genetic information, with the instructions needed for our bodies to develop and function. DNA…

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Investigating The Role of Nuclear And Mitochondrial Variation in Cardiovascular Disease

Abstract Cardiovascular disease (CVD) refers to a complex heterogeneous cluster of diseases of the heart and blood vessels that often manifest clinically as outcomes of myocardial infarction and stroke. CVD is a major public health burden that affects 85 million people just in the United States. As a complex disease…

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Urinary mitochondrial DNA may be useful in diagnosing early diabetic nephropathy

Authors: Li Xue Xue Yang Yuanyuan Song Can Wang Junjie Zhou Hongyan Liang View Affiliations Affiliations: Department of Clinical Laboratory, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China Published online on: October 24, 2023     doi.org/10.3892/etm.2023.12270 Article Number: 570 Copyright: © Xue et al. This…

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cGAS-STING triggers inflammaging-associated neurodegeneration | Molecular Neurodegeneration

cGAS-STING triggers inflammaging-associated neurodegeneration In their recent article in Nature, Gulen et al. [1] established the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway as a regulatory driver of inflammaging-associated neurodegeneration in mice. Pharmacological blockade of this pathway in aged mice prevented inflammaging and improved cognitive and motor performance….

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A novel mouse model of mitochondrial disease exhibits juvenile-onset severe neurological impairment due to parvalbumin cell mitochondrial dysfunction

Conditional Tfam knockout in PV-expressing cells causes juvenile-onset of motor deficits and neurological impairment We mechanistically explored the hypothesis of whether selective PV+ cell mitochondrial dysfunction would be sufficient to induce a neurological phenotype reminiscent of human mitochondrial disease14 by creating a suitable in vivo mitochondrial disease model based on…

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Genetic diversity, phylogeography and historical demography of the Golden Jackal, Canis aureus Linnaeus, 1758, in Turkey as inferred from mtDNA sequences

The Golden Jackal, Canis aureus (L., 1758) is one of the most widespread species of canids, ranging from Central Europe and the Balkans to the Middle East and East Asia; however, relatively little is known about genetic diversity, population structure, and evolutionary history of the Turkish population, which occurs at…

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Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

Title Retraction Note to: Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice Creator Safdar, Adeel; Khrapko, Konstantin; Flynn, James M; Saleem, Ayesha; De Lisio, Michael; Johnston, Adam P W; Kratysberg, Yevgenya; Samjoo, Imtiaz A; Kitaoka, Yu; Ogborn, Daniel I; Little, Jonathan P.; Raha, Sandeep; Parise, Gianni; Akhtar, Mahmood; Hettinga,…

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Custom Software Solution for Forensic mtDNAnalysis of MiSeq Data

Abstract The use of a next-generation sequencing (NGS) approach for mitochondrial (mt) DNA analysis in forensic casework is imminent. A feature of the NGS approach is the ability to detect and report mtDNA heteroplasmy, which will significantly enhance the discrimination potential of the testing method. The current article addresses the…

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Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

. 2023 Oct 18;13(1):17796. doi: 10.1038/s41598-023-45078-3. Affiliations Expand Affiliations 1 Department of Pathology, Stanford University School of Medicine, 300 Pasteur Dr., R271/217, Stanford, CA, 94305, USA. 2 Department of Biological Sciences, San Jose State University, San Jose, CA, 95192, USA. 3 Department of Experimental Medical Science, Lund University, Lund, Sweden….

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Mechanism of sperm mtDNA elimination

Mechanism of sperm mtDNA elimination Premium accounts now available! Sign up and create a premium account. Read more Life Science Network Close Life Science Network This site uses cookies. Some cookies are essential to make the site work and others help us to improve our services.View Cookie settings or read…

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France mtDNA – Overview | FamilyTreeDNA

English version below Le projet France ADNmt s’adresse à toute personne pouvant retracer sa lignée maternelle directe en France ou dans tout pays ayant une population importante d’ascendance française (Canada, États-Unis (Louisiane, Huguenots, Créoles), Antilles (Créoles), France, Suisse, Belgique, Luxembourg). The France mtDNA project is for anyone who can trace…

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Mitochondrial DNA Copy Number as a Biomarker of Multiple Sclerosis

Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system (CNS). In its early stages, it results in inflammation, demyelination, and axonal loss. Egypt has the highest rates in the Middle East region. The pathogenicity of MS involves mitochondrial function. Damage to mitochondrial DNA (mtDNA) can…

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Who is Mitochondrial Eve?

Our Mother, Our shared legacy Imagine a journey back in time to the dawn of humanity. You follow the footsteps of your ancestors, travelling across vast continents and treacherous seas. Along the way, you witness the birth of new cultures and the rise and fall of civilizations. Your journey finally…

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Inactive S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in human stem cell model of Parkinson’s disease

Cloning of CRISPR/sgRNA lentiviral constructs with fluorescent selection markers A tetracycline-inducible promoter (TRE3G) was used to control the expression of S. aureus dCas9 in a lentiviral vector. To facilitate selection of cells by FACS, pHR:TRE3G-SadCas9-2xKRAB-p2a-tdTomato (Addgene ID #209298) was subcloned from a pHR:TRE3G-SadCas9-2xKRAB-p2a-zeo (A gift from Professor Stanley Qi), where zeocin…

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‘Coming Home’ | Tri City Times

73 years later, Korean War soldier identified, to be buried in Imlay City   WASHINGTON — At long last, after 73 years of few answers, family members of Lewis W. Hill can rest easy. Remains of their loved one have been identified by the military. In a recent press release,…

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Broken mitochondria are guilty of obesity

Picture 1. Collective of authors of the research. Source: Natalia Todosenko. Scientists from Immanuel Kant Baltic Federal University on the base of literary sources have described in detail the connection between intracellular processes in mitochondria and metabolic disorders in human’s organism that lead to obesity and cardiovascular diseases. Results of…

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Fish Species Thought To Be Extinct Is Actually Alive And Thriving

A fish species believed to have vanished from the North Sea has made a remarkable comeback, defying earlier claims of extinction. The houting, which had been officially classified as extinct in 2008, is now found to be alive and thriving, according to research conducted by the University of Amsterdam and…

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Y Chromosome DNA Test | IDTO Immigration DNA Paternity Testing Center

Home » Paternity » Y chromosome DNA Test Table of Contents Y DNA Test – What is it? A Y-DNA test is a type of genetic test that is used to analyze the Y-chromosome, which is passed from father to son. This test is used primarily in genealogical research to…

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Extinct fish is alive and well

The anadromous houting Coregonus oxyrinchus is listed as “extinct” on the IUCN Red List. The taxonomic distinction between C. oxyrinchus and the similarly related C. lavaretus is based on a debatable morphological comparison, therefore, its extinct status may not be accurate. Additionally, phylogenetic analyses of mtDNA only included recently discovered…

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Fish That Scientists Thought Was Extinct Is Actually Abundant, Study Finds

A species of fish thought to have gone extinct 15 years ago has surprised scientists after being found living happily in the wild. The houting, a whitefish species found throughout estuaries in the North Sea, was declared officially extinct in 2008. Now, researchers have used DNA taken from specimens of…

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Haplogroup M8 – Wikipedia

From Wikipedia, the free encyclopedia This article is about the human mtDNA haplogroup. For the human mtDNA haplogroup, see Haplogroup C (mtDNA). Haplogroup M8 Possible time of origin 34,400 YBP[1] Possible place of origin East Asia Ancestor M Descendants M8a, CZ Defining mutations A4715G C7196a G8584A A15487t T16298C[1] In human…

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Reduced Maternal Circulating Cell-Free Mitochondrial DNA Is Associated With the Development of Preeclampsia

Background Circulating cell-free mitochondrial DNA (ccf-mtDNA) is a damage-associated molecular pattern that reflects cell stress responses and tissue damage, but little is known about ccf-mtDNA in preeclampsia. The main objectives of this study were to determine (1) absolute concentrations of ccf-mtDNA in plasma and mitochondrial DNA content in peripheral blood…

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STING in tumors: a focus on non-innate immune pathways

The final, formatted version of the article will be published soon. Notify me Receive an email when it is updated You just subscribed to receive the final version of the article Cyclic GMP-AMP synthase (cGAS) and downstream stimulator of interferon genes (STING) are involved in mediating…

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Study Suggests a New Mechanism of Cellular Senescence

Scientists have found that leakage of mitochondrial DNA in senescent cells is a major cause of their pro-inflammatory activity, and it can be targeted without clearing those cells out [1]. To do this, we need your support. Your charitable contribution tranforms into rejuvenation research, news, shows, and more. Will you…

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Mitochondrial DNA damage tied to Parkinson’s neurodegeneration

Damage to the genetic material in mitochondria, cells’ energy production centers, may trigger the spread of nerve cell death in Parkinson’s disease, according to recent research. Faulty mitochondrial DNA (mtDNA) was observed in patient tissues and mouse models. In lab studies, the damaged mtDNA was found to be released from…

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Scientists unlock biological secrets of the aging process

Credit: Nature (2023). DOI: 10.1038/s41586-023-06621-4 How we grow old gracefully—and whether we can do anything to slow down the process—has long been a fascination of humanity. However, despite continued research the answer to how we can successfully combat aging still remains elusive. Now, a new study led by scientists at…

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Mitochondrial SOS: how mtDNA may act as a stress signal in Alzheimer’s disease

Review doi: 10.1186/s13195-023-01322-6. Affiliations Expand Affiliations 1 Department of Microbiology, Immunology, and Genetics, School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX, USA. 2 Department of Family Medicine, Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA. 3…

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5.docx – Show Cell breakdown in the lungs is a compromising improvement starting from bronchial epithelial cells and is the important driver of unrest

Show Cell breakdown in the lungs is a compromising improvement starting from bronchial epithelial cells and is the important driver of unrest related passing in China1. Over 80% of them are non-little cell breakdown in the lungs (NSCLC) taking into account morphological characteristics. Development, drug treatment and radiotherapy are taken…

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6.2.docx – Show Cell breakdown in the lungs is a compromising improvement beginning from bronchial epithelial cells and is the immense driver of

Show Cell breakdown in the lungs is a compromising improvement beginning from bronchial epithelial cells and is the immense driver of conflict related passing in China1. More than 80% of them are non-little cell breakdown in the lungs (NSCLC) considering morphological qualities. Improvement, drug treatment and radiotherapy are taken on…

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Toxic DNA Fragments May Be What Triggers Parkinson’s Disease : ScienceAlert

A first-of-its-kind study reveals that damaged mitochondrial DNA sets off a chain reaction that can spread Parkinson’s disease to other parts of the brain in a similar way to an infection. Mitochondria – tiny organelles in our cells that produce energy – contain a DNA bank of their very own,…

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Mitochondrial SOS: how mtDNA may act as a stress signal in Alzheimer’s disease | Alzheimer’s Research & Therapy

2021 Alzheimer’s disease facts and figures – 2021 – Alzheimer’s & Dementia – Wiley Online Library. Available from: alz-journals.onlinelibrary.wiley.com/doi/doi.org/10.1002/alz.12328. [Cited 2022 Nov 13]. Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA research framework: toward a biological definition of Alzheimer’s disease. Alzheimers Dement J…

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If as they claim all modern humans come from Africa, than why is our

MtDNA isn’t the only DNA to tell a story—the DNA found in the chromosomes in the nucleus of our cell tells a story, too, but it is comprised of jumbled bits and pieces that could have been inherited from any one of our ancestors. The mtDNA story line does…

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Stressed mitochondria sound the alarm.

Immunology and Cell Biology (2015), 1–2 & 2015 Australasian Society for Immunology Inc. All rights reserved 0818-9641/15 www.nature.com/icb NEWS AND COMMENTARY mtDNA stress triggers interferon production Stressed mitochondria sound the alarm Michael J White and Benjamin T Kile Immunology and Cell Biology advance online publication, 10 March 2015; doi:10.1038/icb.2015.31 M…

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Contig size files for supplementary figures

Nuclear and organellar genomes can evolve at vastly different rates despite occupying the same cell. In most bilaterian animals, mitochondrial DNA (mtDNA) evolves faster than nuclear DNA, whereas this trend is generally reversed in plants. However, in some exceptional angiosperm clades, mtDNA substitution rates have increased up to 5000-fold compared…

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Comparing effective female population size and population history of Tor tambroides from gene COI (MTDNA)

Arif, Wibowo (2015) Comparing effective female population size and population history of Tor tambroides from gene COI (MTDNA). In: Prosiding Seminar Nasional Limnologi VII, 16 Sep 2014, Gedung APCE, Cibinong Science Centre-Botanical Garden. Abstract The mahseer (Tor tambroides) is an important commercially fishes in Indonesia. Here we-analyze DNA sequence data…

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Human Race s lap report.docx – Jahnya Hill BIOL -2610L May 3 2023 Human Race s Relations Lab Report Introduction Based on the hypothesis given in the

Jahnya Hill BIOL -2610L May 3, 2023 Human Race(s) Relations Lab Report Introduction Based on the hypothesis given in the lab exercise “Within the species Homo sapiens there are multiple races, or subspecies, that are genetically distinct from one another.” (Marion and Preszler, 2020) I believe that there are no…

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Genetic characteristics of complete mtDNA genome sequence of Indonesian local rabbit (Oryctolagus cuniculus)

Background: Indonesian local rabbit (Oryctolagus cuniculus) is a local breed in Indonesia. We reveal the mitochondrial genome sequence of the Indonesian local Rabbit for the first time. A better understanding of the mechanisms underlying these beneficial aspects of local breeds over imported ones requires detailed genetic investigations, of which mtDNA…

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The activation of cGAS-STING in acute kidney injury

Introduction AKI, which is characterised by necroinflammation due to damage and necrosis of the kidney’s intrinsic cells,1 is a common clinical syndrome, occurring in 10–15% of hospitalized patients, whereas in the ICU this percentage is as high as 50%.2 The development of AKI is involved in the production of reactive…

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Reneo Pharmaceuticals Announces Last Patient Last Visit in the Pivotal STRIDE Study of Mavodelpar in Primary Mitochondrial Myopathies (PMM)

Reneo Pharmaceuticals, Inc. Topline data results from the STRIDE study are expected in December 2023 IRVINE, Calif., Oct. 09, 2023 (GLOBE NEWSWIRE) — Reneo Pharmaceuticals, Inc. (Nasdaq: RPHM), a clinical-stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, announced last patient…

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Profiling mitochondrial DNA mutations in tumors and circulating extracellular vesicles of triple-negative breast cancer patients for potential biomarker development

. 2023 Sep 8;5(10):412-426. doi: 10.1096/fba.2023-00070. eCollection 2023 Oct. Affiliations Expand Affiliations 1 Mitchell Cancer Institute, University of South Alabama Mobile Alabama USA. 2 Department of Pathology, College of Medicine University of South Alabama Mobile Alabama USA. 3 Department of Mathematics and Statistics University of South Alabama Mobile Alabama USA….

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What is the longest DNA confirmed matrilineal relationship in WikiTree?

Is this (currently) the longest matrilineal line in WikiTree which can be confirmed with sufficiently matching mtDNA?  www.wikitree.com/index.php?title=Special:Relationship&action=calculate&person1_name=Sullivan-17177&person2_name=Arsenault-64&relationshipLimit=maternal The individuals are 10th cousins once removed, with a single HVR1 difference observed on a full sequence test. If logged into mitoYDNA.org, you can compare their mtDNA through WikiTree: www.mitoydna.org/public/mtCompare?MtyID=T17859%2CT17837 Read more here:…

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A Comparative Analysis of Mitochondrial Genome Mutation Spectra in Human Populations

Brown W.M., George M., Wilson A.C. 1979. Rapid evolution of animal mitochondrial DNA. Proc. Natl. Acad. Sci. U. S. A. 76, 1967–1971. Article  CAS  PubMed  PubMed Central  Google Scholar  Giles R.E., Blanc H., Cann H.M., Wallace D.C. 1980. Maternal inheritance of human mitochondrial DNA. Proc. Natl. Acad. Sci. U. S….

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The known unknowns of mitochondrial carcinogenesis: de novo NUMTs and intercellular mitochondrial transfer

doi: 10.1093/mutage/gead031. Online ahead of print. Affiliations Expand Affiliation 1 Department of Genetics and Cytology, Yerevan State University, 1 Alex Manoogian, 0025 Yerevan, Armenia. Item in Clipboard Tigran Harutyunyan. Mutagenesis. 2023. Show details Display options Display options Format AbstractPubMedPMID doi: 10.1093/mutage/gead031. Online ahead of print. Affiliation 1 Department of Genetics…

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Association Between Whole Blood-Derived Mitochondrial DNA Copy Number, Low-Density Lipoprotein Cholesterol, and Cardiovascular Disease Risk

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We…

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A New Clue Into the Cause, Spread of Parkinson’s Disease?

Damaged mitochondrial DNA (mtDNA) initiates and spreads Parkinson’s disease (PD) pathology, potentially opening new avenues for early diagnosis, disease monitoring, and drug development. While defects in mitochondrial functions and in mitochondrial DNA have been implicated in PD in the past, the current study demonstrates “for the first time how damaged…

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