Tag: MTHFD1
Mthfd1 – PrimePCR Assay and Template | Life Science
Control assays and synthetic DNA templates were designed to facilitate the assessment of the key experimental factors impacting your real-time PCR results. DNA Contamination Control AssayUse the PrimePCR DNA contamination control assay to determine if genomic DNA (gDNA) is present in a sample at a level that may affect PCR…
Targeting MTHFD1 and MTHFD2 as cancer treatment
Abstract: One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and therefore plays a central role in DNA replication and repair. To sustain rapid proliferation, cancer cells often upregulate their 1C metabolism, including the enzymes MTHFD1 and MTHFD2, as a part of their metabolic rewiring. Previously, MTHFD2 in particular has…
MTHFD1 Polyclonal Antibody | ARP American Research Products, Inc.
MTHFD1 Polyclonal Antibody | ARP American Research Products, Inc. The store will not work correctly when cookies are disabled. JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser. More Information Product Name MTHFD1 Polyclonal Antibody…
Recombinant Human MTHFD1 protein (ab116852)
Recombinant Human MTHFD1 protein is a Wheat germ Full Length protein 1 to 935 aa range and validated in SDS-PAGE, ELISA, WB. Alternative names= C1TC, MTHFC, MTHFD, MTHFD1, C1TC_HUMAN, C1-THF synthase, C1 THF synthase, OTTHUMP00000180657, Formyltetrahydrofolate synthetase, Methenyltetrahydrofolate cyclohydrolase, Methylenetetrahydrofolate dehydrogenase, C1 tetrahydrofolate synthase cytoplasmic, C 1 tetrahydrofolate synthase cytoplasmic,…
What type of word is ‘mthfd1’? Mthfd1 can be
Unfortunately, with the current database that runs this site, I don’t have data about which senses of ~term~ are used most commonly. I’ve got ideas about how to fix this but will need to find a source of “sense” frequencies. Hopefully there’s enough info above to help you understand the…
KEGG T01001: 4522
Entry 4522 CDS T01001 Symbol MTHFD1, CIMAH, MTHFC, MTHFD Name (RefSeq) methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 KO K00288 methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3] Organism hsa Homo sapiens (human) Pathway hsa00670 One carbon pool by folate hsa01100 Metabolic pathways hsa01240 Biosynthesis of cofactors Module hsa_M00141 …
Nutrients | Free Full-Text | Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease
1. Introduction Congenital heart defect (CHD) is the most prevalent congenital malformation worldwide and has emerged as the leading cause of death among children under five years old in China [1,2]. While surgical interventions have improved survival rates, CHD patients often experience long-term cardiovascular and systemic complications, leading to substantial…
CpG-SNP site methylation regulates allele-specific expression of MTHFD1 gene in type 2 diabetes
CpG-SNP site methylation regulates allele-specific expression of MTHFD1 gene in type 2 diabetes – Fingerprint — Manipal Academy of Higher Education, Manipal, India Sort by Weight Alphabetically Biochemistry, Genetics and Molecular Biology Nested Gene 100% Methylation 100% Single Nucleotide Polymorphism 100% Allele 100% DNA Methylation 33% Genetics 33% Carbon Metabolism…
MTHFD1 G1958A and CBS 844ins68 polymorphism and its relationship with CHD in North Indian population
The approximate number of children born with congenital heart disease in India is more than 200,000 per year. A recent study published in the Indian Journal of Medical Sciences (Scientific Scholar) showed that both MTHFD1 G1958A and CBS 844ins68 polymorphism were not found to be genetic risk factors in the…
(PDF) Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency | Elena Kamynina
(PDF) Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency | Elena Kamynina – Academia.edu Academia.edu uses cookies to personalize content, tailor ads and improve the user experience. By using our site, you agree to our collection of information through the…
Formate overflow drives toxic folate trapping in MTHFD1 inhibited cancer cells
TH9619/TH9975 target MTHFD1(DC) but not mitochondrial MTHFD2 In our recent study, we demonstrated that loss of MTHFD2 caused resistance to TH9619, validating MTHFD2 as a target of TH9619 (ref. 16). Yet, we showed that the effect of TH9619 is metabolically rescued by addition of thymidine, but not with hypoxanthine. This…
The negative effect of G1958A polymorphism on MTHFD1 protein stability and HCC growth
R.L. Siegel, K.D. Miller, H.E. Fuchs, A. Jemal, CA Cancer J. Clin 72 (2022). doi.org/10.3322/caac.21708 J.M. Llovet, F. Castet, M. Heikenwalder, M.K. Maini, V. Mazzaferro, D.J. Pinato, E. Pikarsky, A.X. Zhu, R.S. Finn, Nat. Rev. Clin. Oncol 19, 151–172 (2022). doi.org/10.1038/s41571-021-00573-2 Article CAS PubMed Google Scholar J.M. Llovet, T. De Baere, L. Kulik,…
Doubly bi-allelic variants of MTHFR and MTHFD1 in a Chinese patient with hyperhomocysteinemia and failure of folic acid therapy
doi: 10.3389/fgene.2022.964990. eCollection 2022. Affiliations Expand Affiliations 1 Department of Neurology, Xuzhou Central Hospital, Xuzhou, China. 2 Department of Cell Biology, School of Life Sciences, Central South University, Changsha, China. 3 Department of Radiotherapy, Xuzhou Cancer Hospital, Xuzhou, China. 4 Department of Respiratory Medicine, Diagnosis and Treatment Center of Respiratory…
Struts Problem Report
Struts Problem Report Struts Problem Report Struts has detected an unhandled exception: Messages: actions.Fusions.fusion?geneNameA=ZBTB1&geneNameB=MTHFD1() File: java/lang/Class.java Line number: 1,786 Stacktraces java.lang.NoSuchMethodException: actions.Fusions.fusion?geneNameA=ZBTB1&geneNameB=MTHFD1() java.lang.Class.getMethod(Class.java:1786) org.apache.struts2.interceptor.validation.AnnotationValidationInterceptor.getActionMethod(AnnotationValidationInterceptor.java:75) org.apache.struts2.interceptor.validation.AnnotationValidationInterceptor.doIntercept(AnnotationValidationInterceptor.java:47) com.opensymphony.xwork2.interceptor.MethodFilterInterceptor.intercept(MethodFilterInterceptor.java:98) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) com.opensymphony.xwork2.interceptor.ConversionErrorInterceptor.intercept(ConversionErrorInterceptor.java:138) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) com.opensymphony.xwork2.interceptor.ParametersInterceptor.doIntercept(ParametersInterceptor.java:238) com.opensymphony.xwork2.interceptor.MethodFilterInterceptor.intercept(MethodFilterInterceptor.java:98) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) com.opensymphony.xwork2.interceptor.ParametersInterceptor.doIntercept(ParametersInterceptor.java:238) com.opensymphony.xwork2.interceptor.MethodFilterInterceptor.intercept(MethodFilterInterceptor.java:98) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) com.opensymphony.xwork2.interceptor.StaticParametersInterceptor.intercept(StaticParametersInterceptor.java:191) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) org.apache.struts2.interceptor.MultiselectInterceptor.intercept(MultiselectInterceptor.java:75) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) org.apache.struts2.interceptor.CheckboxInterceptor.intercept(CheckboxInterceptor.java:90) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) org.apache.struts2.interceptor.FileUploadInterceptor.intercept(FileUploadInterceptor.java:252) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) com.opensymphony.xwork2.interceptor.ModelDrivenInterceptor.intercept(ModelDrivenInterceptor.java:100) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) com.opensymphony.xwork2.interceptor.ScopedModelDrivenInterceptor.intercept(ScopedModelDrivenInterceptor.java:141) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) com.opensymphony.xwork2.interceptor.ChainingInterceptor.intercept(ChainingInterceptor.java:145) com.opensymphony.xwork2.DefaultActionInvocation.invoke(DefaultActionInvocation.java:242) com.opensymphony.xwork2.interceptor.PrepareInterceptor.doIntercept(PrepareInterceptor.java:171)…
Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A systematic review and meta-analysis – Huaxiang Zhao, Jieni Zhang, Mengqi Zhang, Feng Deng, Leilei Zheng, Hui Zheng, Feng Chen, Jiuxiang Lin
@article{Zhao2015, author = {Zhao, Huaxiang and Zhang, Jieni and Zhang, Mengqi and Deng, Feng and Zheng, Leilei and Zheng, Hui and Chen, Feng and Lin, Jiuxiang}, doi = {10.12688/f1000research.6425.2}, journal = {F1000Research}, month = {jun}, title = {Is MTHFD1 polymorphism rs 2236225 (c.1958G>A) associated with the susceptibility of NSCL/P? A…
Frontiers | Association of Maternal Dietary Habits and MTHFD1 Gene Polymorphisms With Ventricular Septal Defects in Offspring: A Case-Control Study
Introduction Congenital heart disease (CHD) refers to a group of anatomic heart and great vessel malformations that arise during the embryologic development of the fetus. CHD is one of the most prevalent birth defects, affecting around 2.50 out of every 1,000 births in China (1), and it imposes a substantial…
Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy
Orthogonal genome-wide screens of bat cells identify MTHFD1 as a target of broad antiviral therapy Danielle E. Anderson, Jin Cui, Qian Ye, Baoying Huang, Ya Tan, Chao Jiang, Wenhong Zu, Jing Gong, Weiqiang Liu, So Young Kim, Biao Guo Yan, Kristmundur Sigmundsson, Xiao Fang Lim, Fei Ye, Peihua Niu, Aaron…
