Categories
Tag: MYC
16 UK biotech companies you should know about
The UK is home to several biotech hubs, including the famous ‘golden triangle’, made up of Oxford, Cambridge, and London. In fact, after a $700 million surge in funding in the third quarter of 2023, the UK biotech scene is now one of the most vibrant in Europe, laying the…
Prashant Mehta: My thoughts on developments in DLBCL management
Prashant Mehta, Senior Consultant and Assistant Professor in the Department of Medical Oncology/Hematology-oncology and Bone marrow transplantation at the Amrita Hospital, Faridabad, shared a thread on X/Twitter: “My thoughts on developments in Diffuse Large B Cell Lymphoma (DLBCL) management: Despite several combination studies with R-CHOP, in the last 20 years…
Vincerx Pharma Announces Compelling Clinical Efficacy of Enitociclib in Combination with Venetoclax and Prednisone in Lymphoma
Vincerx Pharma, Inc. Investigators from the National Institutes of Health (NIH) report 2 partial responses (PR) in 3 peripheral T-cell lymphoma (PTCL) patients and 1 PR in 2 double-hit diffuse large b-cell lymphoma (DH-DLBCL) patients in ongoing dose-escalation trial of enitociclib in combination with venetoclax and prednisone Vincerx remains on…
Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential
MYC translocation occurs in 8-14% of diffuse large B-cell lymphoma (DLBCL), and may concur with BCL2 and/or BCL6 translocation, known as double-hit (DH) or triple-hit (TH). DLBCL-MYC/BCL2-DH/TH are largely germinal centre B-cell like subtype, but show variable clinical outcome, with IG::MYC fusion significantly associated with inferior survival. While DLBCL-MYC/BCL6-DH are…
Identifying Prognostic Genes in Diffuse Large B-cell Lymphoma (DLBCL)
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, a cancer that starts in cells called lymphocytes, which are part of the body’s immune system. Its progression and prognosis vary significantly among patients, making it crucial to identify prognostic factors that can help predict patient outcomes…
Anti-EpCAM (Extracellular region) Antibody | Scientist.com
Anti-EpCAM (Extracellular region) Antibody | Scientist.com Skip to Main Content Go to Main Navigation Form: Protein G Purified Gene: EPCAM Host: Mouse Rrid: AB_3068418 Type: Primary Antibody Clone: M039 Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol Target: EpCAM (Extracellular region) Isotype: IgG1 Storage: Storage at -20°C…
Diffuse Large B-Cell Lymphoma (DLBCL) Probe Panel by FISH – Laboratory Test Catalog
Test Name Alias DLBCL by FISH | Double Hit Lymphoma by FISH | Triple Hit Lymphoma by FISH | 9223 Interface Order Alias 11604 Clinical Information This probe panel detects specific structural chromosome abnormalities commonly associated with Diffuse Large B-cell Lymphoma. Routine chromosome analysis is performed on all diagnostic…
ASH 2023: Lymphoma Studies May Inform Practice
Studies presented at the ASH Annual Meeting 2023 provided new insights and updates that may inform the treatment of lymphomas. Results from the phase 3 SYMPATICO trial showed that adding venetoclax to ibrutinib can improve progression-free survival (PFS) in patients with relapsed or refractory mantle cell lymphoma (MCL).1 These results…
Outcomes of allogeneic hematopoietic stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma
Coiffier B, Lepage E, Briere J, Herbrecht R, Tilly H, Bouabdallah R, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002;346:235–242. Article CAS PubMed Google Scholar Philip T, Guglielmi C, Hagenbeek A, Somers R, Van der Lelie…
PRRG4 regulates mitochondrial function and promotes migratory behaviors of breast cancer cells through the Src-STAT3-POLG axis | Cancer Cell International
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality Worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49. doi.org/10.3322/caac.21660. Article PubMed Google Scholar Hu G, Chong RA, Yang Q, Wei Y, Blanco…
Ubiquitination-mediated Golgi-to-endosome sorting determines the toxin-antidote duality of fission yeast wtf meiotic drivers
The toxin and antidote products of cw9 are active in vegetative cells We used the S. pombe wtf gene cw9, which is an active KMD from the natural isolate CBS55579, as a model to study the molecular mechanism underlying the distinction between the toxin and the antidote. We will refer…
Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma
Whole-genome sequencing (WGS) analysis of early and advanced adenocarcinomas Whole-genome short read and long read sequencing datasets of 76 lung cancer specimens were analyzed. The datasets included newly generated data for 48 early small-sized lung adenocarcinoma cases (collectively called “Early-Ad” hereafter). These cases included 26 AIS (9 and 17 cases…
Formononetin | FGFR2 inhibitor | Axon 4067
All All Products Enzymes Receptors Ion Channels Research Areas Oxidoreductases Transferases Lyases Isomerases Ligases Nuclear Receptors Ligand-gated ATP-Sensitive Angiogenesis Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology CNS Diabetes & Metabolism Epigenetics Immunology Miscellaneous Pain & Inflammation Stem Cell Oxidases MAO Cys-loop, cationic Cis-Trans Isomerase CypA DNA Topoisomerase Synthetases…
Studying the role of BCL2 and MYC in the pathogenesis of diffuse large B cell lymphoma
Studying the role of BCL2 and MYC in the pathogenesis of diffuse large B cell lymphoma Keywords: Materias Investigacion::Ciencias de la Salud::GenéticaDiffuse large B cell lymphomaBCL2MYCB-Cell lymphomagenesisLinfoma difuso de células B Defense Date: 21-Jun-2023 Publisher: Universidad de Navarra Citation: MELCHOR, Javier. “Studying the role of BCL2 and MYC in the…
Axi-Cel Delivers Long-Lasting Responses in High-Risk Large B-cell Lymphoma
Lymphoma | Image Credit: © David A Litman – www.stock.adobe.com.jpg Durable responses were seen when axicabtagene ciloleucel (axi-cel; Yescarta) was administered as a first-line therapy for patients with high-risk large B-cell lymphoma (LBCL), according to findings from the phase 2 ZUMA-12 trial (NCT03761056), which were presented at the 2023 American…
Regulation of the ER-Resident Mannosidase EDEM2 in HEK293 Cells
Abstract EDEM2 plays an important role as the first enzyme that acts during mannose trimming of N-glycosylated proteins in the ERAD machinery. Although EDEM2 expression has been reported to be transcriptionally regulated by the IRE1-sXBP1 pathway, very little is known about how endogenous EDEM2 protein expression is regulated. In this…
IJMS | Free Full-Text | The Link of mRNA and rRNA Transcription by PUF60/FIR through TFIIH/P62 as a Novel Therapeutic Target for Cancer
This study demonstrated the novel coactivation mechanism of mRNA and rRNA underlying the role of FIR and its splicing variant, FIRΔexon2. Because FIR is immunoprecipitated with P89 and P62 of TFIIH [7], FIR potentially affects RNAPII-mediated transcription via TFIIH. As expected, FIR affected the mRNA expression of various cancer-related genes…
Khan Discusses Third-Line Novel Treatment Approaches for R/R DLBCL
Cyrus M. Khan, MD (MODERATOR) Hematologist Division of Hematology and Cellular Therapy West Penn Hospital of Allegheny Health Network Pittsburgh, PA EVENT REGION Pennsylvania PARTICIPANT LIST Haixia Qin, MD, PhD | Simi Rai, MD | Naeem Latif, MD | Alexander Barsouk, MD | Gurprataap Sanhu, MD | Hayman Salib, MD…
Older DLBCL Patients Overestimate Chance for Cure, Survey Says
A new survey shows that older adults with aggressive non-Hodgkin lymphoma tend to overestimate their chance for a cure, highlighting a need for better patient education. Results were presented at the 65th ASH Annual Meeting and Exposition by Netana Markovitz, MD, of Beth Israel Deaconess Medical Center in Boston, and…
Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition
Patients, tumour Implantation, PDX expansion and characterization The study was conducted according to the Declaration of Helsinki. Tumours were collected from EC patients following Human Research Ethics Committee (HREC) approval (HREC/15/MHS/127) and QUT HREC (#1500000169, 1500000323). All participants provided written informed consent that their excess tissue could be used for…
Noncoding mutations cause super-enhancer retargeting resulting in protein synthesis dysregulation during B cell lymphoma progression
B cells undergo a series of programmed genomic alterations that enable the immunoglobulin light and heavy chain loci to generate high-affinity antibodies against invading pathogens. First, B cells undergo variability, diversity and joining (VDJ) recombination in the bone marrow with subsequent somatic hypermutation (SHM) and class switch recombination (CSR) occurring…
Altered Glia-Neuron Communication in Alzheimer’s Disease Affects WNT, p53, and NFkB Signaling Determined by snRNA-seq
Abstract Background: Alzheimer’s disease is the most common cause of dementia and is characterized by amyloid-β plaques, tau neurofibrillary tangles, and neuronal loss. Although neuronal loss is a primary hallmark of Alzheimer’s disease, it is known that non-neuronal cell populations are ultimately responsible for maintaining brain homeostasis and neuronal health…
Physicians Consider Loncastuximab for Older Patients With R/R DLBCL
Paolo Strati, MD Assistant Professor Department of Lymphoma/Myeloma The University of Texas MD Anderson Cancer Center Houston, TX CASE SUMMARY: A 73-year-old woman presented with fever, headaches, and 7-lb unintentional weight loss. She was married with 2 grown children who live in other states and the primary caretaker for her mother…
Updated Data Show Efficacy of Tafasitamab/Lenalidomide in R/R DLBCL
CASE A 67-year-old man presented with fatigue, back pain, and lymphadenopathy. Medical history: Hypertension, well controlled with medication Physical exam: Left posterior cervical, 1.5-cm node; right anterior cervical node, 2.5-cm; left supraclavicular node, 2.0-cm. PET-CT scan: multiple enlarged mesenteric and retroperitoneal nodes, largest measuring 5.3 x 3.1 cm Bone marrow biopsy was…
Histologically Transformed MZL May Be Distinct Tumor Type
The clinicopathologic and genetic features of marginal zone lymphomas (MZL) with histologic transformation (HT-MZL) suggest that they may be a distinct tumor type from other MZLs. In addition, the higher rates of TBL1XR1 mutations in HT-MZL suggest this could be a predictor for transformation. The study, which was published in…
Two mitochondrial HMG-box proteins, Cim1 and Abf2, antagonistically regulate mtDNA copy number in Saccharomyces cerevisiae | Nucleic Acids Research
Abstract The mitochondrial genome, mtDNA, is present in multiple copies in cells and encodes essential subunits of oxidative phosphorylation complexes. mtDNA levels have to change in response to metabolic demands and copy number alterations are implicated in various diseases. The mitochondrial HMG-box proteins Abf2 in yeast and TFAM in mammals…
Molecular complexity of diffuse large B-cell lymphoma: a molecular perspective and therapeutic implications
Agarwal P, Kabir FM, DeInnocentes P, Bird RC (2012) Tumor suppressor gene p16/INK4A/CDKN2A and its role in cell cycle exit, differentiation, and determination of cell fate. Tumor Suppressor Genes 3(10):27882 Google Scholar Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E et al (2022) The 5th edition…
Genome wide analysis revealed conserved domains involved in the effector discrimination of bacterial type VI secretion system
Construction of the VgrG database Encoded as a stand-alone gene or fused at the N-terminus of the toxin, the MIX domains can assist the delivery of their cognate T6SS effector19,20. As the central component of the spike complex, VgrG is a good marker to explore the potential conserved domains involved…
A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei
Cell growth and transfections Procyclic form (PCF) T. brucei, strain 29-1354, which carries integrated genes for the T7 polymerase and the tetracycline repressor, was grown in SDM-79 medium supplemented with 10% fetal calf serum, in the presence of 50 μg/ml hygromycin. Cells were grown in the presence of 15 μg/ml G418 for…
GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21
Experimental model and subject details Mice Male ICR mice (Laboratory Animal Center of Zhejiang Academy of Medical Sciences) at age of 3 months (M), 9 M and 36 M, male C57BL/B6 wild‐type (WT) mice (Shanghai Slac Laboratory) at age of 3 M and 10 M, male GDF11-flox mice (GDF11f/f, mice carrying the “floxed” GDF11…
Bioinformatics analysis of immune cell infiltration patterns and potential diagnostic markers in atherosclerosis
A database in the Gene Set Enrichment Analysis (GSEA; www.gsea-msigdb.org/gsea/msigdb/index.jsp) platform10,11 was used to identify 134 GLN metabolism-associated genes. Weighted gene co-expression network analysis (WGCNA) and module screening GLN-associated gene sets were investigated using WGCNA. The results demonstrated that when the weighted value was 24 (Fig. 1A), scale independence was greater…
PPP1R12A is a recycling endosomal phosphatase that facilitates YAP activation
Antibodies Antibodies used in the present study were as follows: rabbit anti-phospho-YAP (S127) (#13008, dilution 1:500), rabbit anti-phospho-LATS1 (S909) (#9157, dilution 1:500), rabbit anti-YAP (#14074, dilution 1:100 for immunofluorescence), and rabbit anti-PPP1R12A (#8574, dilution 1:1000 for western blot, 1:200 for immunofluorescence) from Cell Signaling Technology; rabbit anti-LATS1 (A300-477A, dilution 1:2000)…
[Clinical Characteristics and Correlation with Prognosis of DLBCL with Bone Marrow Involvement and Chromosomal Abnormalities]
Objective: To investigate the clinical characteristics of diffuse large B-cell lymphoma(DLBCL) patients with bone marrow involvement and chromosome abnormalities, and further analyze the correlation between the degree of chromosome abnormality and prognosis. Methods: The clinical data of 88 patients diagnosed with DLBCL with bone marrow involvement and complete chromosomal findings…
Mosunetuzumab in combination with CHOP in previously untreated DLBCL: safety and efficacy results from a phase 2 study
Abstract Up to 40% of patients with diffuse large B-cell lymphoma (DLBCL) are refractory to or relapse after first-line therapy, highlighting the need for better treatments. Mosunetuzumab is a CD20 × CD3 bispecific antibody that engages and redirects T cells to eliminate malignant B cells. In this phase 2, open-label study…
The DNA-binding induced (de)AMPylation activity of a Coxiella burnetii Fic enzyme targets Histone H3
Statistics and reproducibility Anti-AMP IP for LC-MS/MS analysis was performed in three independent biological replicates (n = 3). TSA assay data represents technical triplicates. Time-resolved (de)AMPylation analyzed by LC-MS was performed as biological triplicates. CD measurements were performed in technical triplicates. Anisotropy data is shown as technical triplicates. Anisotropy measurements were repeated…
Characterization of the genomic alterations in poorly differentiated thyroid cancer
Cancer Genome Atlas Research, N. Integrated genomic characterization of papillary thyroid carcinoma. Cell 159, 676–690. doi.org/10.1016/j.cell.2014.09.050 (2014). Sherman, S. I. Thyroid carcinoma. Lancet 361, 501–511. doi.org/10.1016/s0140-6736(03)12488-9 (2003). Article PubMed Google Scholar Tong, J. et al. Poorly differentiated thyroid carcinoma: a clinician’s perspective. Eur. Thyroid J. 11, doi.org/10.1530/ETJ-22-0021 (2022). Asioli, S….
ncRNA | Free Full-Text | Dysregulation of Non-Coding RNAs: Roles of miRNAs and lncRNAs in the Pathogenesis of Multiple Myeloma
4. Dysregulation of lncRNAs in MM In recent years, numerous studies have focused on the role of lncRNAs in MM pathogenesis. Since then, the role of aberrantly expressed lncRNAs in MM has been reported, highlighting the potential in clinical applications. For instance, lncRNAs participate in the differentiation of erythroid, myeloid,…
Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations
Ethical statement Our research complies with all relevant ethical regulations, including the Declaration of Helsinki and has been approved by the Institutional Review Boards of University of Chicago, Duke University and the Alliance to Cure Cavernous Malformations. Cerebral cavernous malformation lesions All human CCM tissue specimens have been previously reported18,19…
Diet-induced rewiring of the Wnt gene regulatory network connects aberrant splicing to fatty liver and liver cancer in DIAMOND mice
DIAMOND mice develop HCC in the context of obesity and insulin resistance To investigate in depth the genome-wide transcriptional and epigenetic changes that occur during development of MAFLD and obesity-related hepatocellular carcinoma (HCC), we performed RNA-sequencing (RNA-seq) and Chromatin ImmunoPrecipitation-sequencing (ChIP-seq) of liver tumours (HCC) and liver control tissue (FL)…
The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer
Cardoso F, Paluch-Shimon S, Senkus E, Curigliano G, Aapro MS et al (2020) 5th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 5). Ann Oncol 31:1623–1649 Article CAS PubMed Google Scholar Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J et al (2013) Circular RNAs are a large…
Phase 2 GUIDANCE Trial of R-CHOP-X Meets Primary End Point in DLBCL
Red blood cells: © vipman4 – stock.adobe.com Rituximab (Rituxan), cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) alone or combined with targeted agents (R-CHOP-X) demonstrated efficacy and safety in patients with newly diagnosed, intermediate-risk, or high-risk diffuse large B-cell lymphoma (DLBCL), according to findings published in Cancer Cell.1 In the randomized, phase…
Induced Pluripotent Stem Cells – Concept | Cell Biology
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are…
Proteomics uncovers molecular features for relapse risk stratification in patients with diffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid cancer, constituting approximately one third of all cases [1]. Although immunochemotherapy cures ~60–75% of patients, a significant proportion of patients still experience relapse [2, 3]. Relapsed DLBCL patients have poor outcomes, with a median overall survival of only 6.3 months…
EpCAM, a broadly expressed, validated cancer target rescued by novel antibody technologies | Antibodies
EpCAM, a broadly expressed, validated cancer target rescued by novel antibody technologies Details Category: Antibodies Published on Tuesday, 24 October 2023 11:51 Hits: 242 BARCELONA, Spain I October 24, 2023 I La Merie Publishing released its newest product reviewing the pipeline of anti-EpCAM antibody therapy candidates in R&D: EpCAM-Targeted…
HOXC-AS3 as an Oncological Biomarker and Therapeutic Target
1Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, 330008, People’s Republic of China; 2Department of General Surgery, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang, Jiangxi, 332007, People’s Republic of China; 3Queen Mary School, Nanchang University, Nanchang, Jiangxi, 330038, People’s Republic of China Correspondence: Hongliang Luo,…
The Age of Aquarius – RNA, the Epicenter of Genetic Information
The veil on genetic information was lifted by the advent of gene cloning and sequencing technologies in the 1970s. The discovery and purification of bacterial nucleases capable of cutting DNA at specific sequences and ligases capable of joining them enabled DNA from any species – or mRNAs converted to complementary…
Seven pioneering molecular glue companies shaping the industry
Since they were discovered around three decades ago, molecular glues have come a very long way as a therapeutic option for several different disease areas, including cancer and neurodegenerative disorders. Now, there are a rising number of molecular glue companies hoping to show clinical success with their candidates. The term…
A non-randomized risk-adjusted comparison of lenalidomide + R-CHOP versus R-CHOP for MYC-rearranged DLBCL patients
Patients with MYC rearranged (MYC-R) diffuse large B-cell lymphoma (DLBCL) have a poor prognosis. Previously, we demonstrated in a single-arm phase II trial (HOVON-130) that addition of lenalidomide to R-CHOP (R2CHOP) is well-tolerated and yields similar complete metabolic remission rates as more intensive chemotherapy regimens in literature. In parallel with…
Additional Treatment Strategies and Collaborative Care for Patients with DLBCL
Leo Gordon, MD: Patients who have mutations of the C-myc gene and the BCL2 gene do worse. We had done a retrospective study looking at different regimens. We, as a standard at our institution, have been using EPOCH [etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin] in those patients and because they…
Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens
Introduction Cancer cells are characterized by unrestrained proliferation and dysregulated growth, which lead to the formation of malignant neoplasms (Hanahan & Weinberg, 2023). The development and progression of cancer have been linked to the dysregulation of multiple signaling pathways, including MAPK/ERK, Wnt/β-catenin, PI3K/AKT/mTOR, and NF-kB, which are among crucial pathways…
Structure of human TRPM8 channel
Reagents and chemicals pFastBac Dual His6 MBP N10 TEV LIC cloning vector (5 C) was purchased from Addgene (Addgene plasmid no. 30123; www.addgene.org/30123). All restriction enzymes, the pFastBac1 vector, and DH10Bac cells were purchased from Thermo Fisher Scientific. Sf9 cells were purchased from ATCC. Q5® High-Fidelity DNA Polymerase, the Monarch® DNA…
Molecule Linking Cancer Driver and Cell Death Genes May Be Effective Against DLBCL | ASH Clinical News
Molecules that link cancer driver genes and promoters of cell death genes produce potent killing of diffuse large B-cell lymphoma (DLBCL) cells, according to findings published in Nature.1 The effectiveness of the molecules, called transcriptional/epigenetic chemical inducers of proximity (TCIPs), in killing cancer cells could have wider implications, potentially co-opting…
Advances in Polatuzumab Vedotin-PIIQ Therapy
Introduction Between 30 to 40% of non-Hodgkin lymphoma cases globally are diffuse B-cell lymphoma (DLBCL), the most prevalent disease. Patients often have a rapidly expanding nodal or extranodal tumor mass in one or more locations.1 The concept of “high-grade B-cell lymphoma” has historically been used to refer to B-cell lymphomas…
Comparative study on the mutation spectrum of L-MYC and C-MYC genes of blood cfDNA in patients with ovarian cancer and healthy females
doi: 10.1111/jog.15808. Online ahead of print. Affiliations Expand Affiliations 1 Centre for Interdisciplinary Biomedical Research, Adesh University, Bathinda, India. 2 Department of Clinical Biochemistry, Govt. College for Women, M. A. Road, Srinagar, Cluster University Srinagar, Kashmir, India. Item in Clipboard Saba Shabir et al. J Obstet Gynaecol Res. 2023. Show details…
HK2 contributes to the proliferation, migration, and invasion of diffuse large B-cell lymphoma cells by enhancing the ERK1/2 signaling pathway
References [1] Thandra KC, Barsouk A, Saginala K, Padala SA, Barsouk A, Rawla P. Epidemiology of Non-Hodgkin’s Lymphoma. Med Sci (Basel). 2021 Jan 30;9(1):5.10.3390/medsci9010005Search in Google Scholar PubMed PubMed Central [2] Mafra A, Laversanne M, Gospodarowicz M, Klinger P, De Paula Silva N, Piñeros M, et al. Global patterns of…
Lunning Discusses Defining and Approaching Treatment for Early-Relapsed DLBCL
Matthew A. Lunning, DO (MODERATOR) Assistant Vice Chancellor of Clinical Research Associate Vice Chair of Research Department of Internal Medicine Associate Professor, Division of Oncology and Hematology University of Nebraska Medical Center Omaha, NE EVENT REGION Minnesota and Nebraska PARTICIPANT LIST Dahlia H. Elkadi, MBBCh | Kurt Demel, MD |…
GenFleet Starts Phase Ib/II Trial of GFH009 (Highly Selective CDK9 Inhibitor) Treating Patients with Relapsed/Refractory Peripheral T-cell Lymphomas (PTCL)
SHANGHAI, Oct. 10, 2023 /PRNewswire/ — GenFleet Therapeutics, a clinical-stage biotechnology company focusing on cutting-edge therapies in oncology and immunology, today announced the first subject was dosed in a phase Ib/II trial of GFH009 (a highly selective CDK9 inhibitor) treating relapsed/refractory PTCL (peripheral T-cell lymphomas) patients. Designed to enroll…
Recombinant Mouse Fgfr2 Protein, Myc/DDK-tagged Fgfr2-3002M
Description : Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis…
The Therapeutic Effects of MUC1-C shRNA@Fe3O4 Magnetic Nanoparticles i
Introduction Breast cancer (BC) is a malignant tumor originating from the epithelial tissue of the breast and is the most common malignancy in women.1 It is estimated that by 2040, there will be 3,000,000 new cases of BC and 100,000 deaths worldwide. Triple-negative breast cancer (TNBC), which accounts for 15–20%…
Epstein-Barr virus infection: the micro and macro worlds | Virology Journal
Epstein MA, Achong BG, Barr YM. VIRUS PARTICLES IN CULTURED LYMPHOBLASTS FROM BURKITT’S LYMPHOMA. Lancet. 1964;1(7335):702–3. Article CAS PubMed Google Scholar Cohen JI, Jaffe ES, Dale JK, Pittaluga S, Heslop HE, Rooney CM, et al. Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United…
Scientific Publications – Hokkaido System Science Co.,Ltd.
List of publications in which HSS NGS services were used is available as noted below. De Novo Genomic Analysis Draft genome sequence of Veillonella tobetsuensis ATCC BAA-2400T isolated from human tongue biofilm.Izumi Mashima, Futoshi NakazawaGenome Announc. 3.4 (2015): e00808-15. Genome sequence of the multiple-β-lactam-antibiotic-resistant bacterium Acidovorax sp. strain MR-S7.Takamasa Miura, Hiroyuki Kusada, Yoichi Kamagata, Satoshi…
Secondary infection surveillance | IDR
Introduction The coronavirus disease 2019 (COVID-19) caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continues to threaten human life worldwide. The disease severity of COVID-19 patients is very wide: from an asymptomatic carrier state to severe infection and critical illness with intensive care admission and/or mechanical…
The Effect of Cell-Free DNA from Blood Serum of Mice with Metastatic Melanoma on Enhancement of Oncogenic Properties of Melanoma Cells
Currently, a significant increase in the levels of circulating cell-free DNA (cfDNA) in the blood of patients is considered as a generally recognized marker of the development of oncological diseases. Although the tumor-associated cfDNA has been well studied, its biological functions remain unclear. In this work, we investigated the effect…
Single-nucleus transcriptomes reveal spatiotemporal symbiotic perception and early response in Medicago
Nutman, P. S. Centenary lecture. Phil. Trans. R. Soc. B 317, 69–106 (1987). Google Scholar Kelly, S., Radutoiu, S. & Stougaard, J. Legume LysM receptors mediate symbiotic and pathogenic signalling. Curr. Opin. Plant Biol. 39, 152–158 (2017). Article CAS PubMed Google Scholar Roy, S. et al. Celebrating 20 years of…
A computationally designed antigen eliciting broad humoral responses against SARS-CoV-2 and related sarbecoviruses
Phylogenetic analysis Protein sequences of spike proteins were downloaded from the NCBI virus database for all the known sarbecoviruses (June 2020). A multiple sequence alignment was generated using MUSCLE36. The resulting multiple sequence alignment was pruned to the RBD region, filtered at 95% sequence identity and used as input for…
Induced Pluripotent Stem Cells (iPSCs) and Genetic Engineering
Benabdellah, K., Sánchez-Hernández, S., Aguilar-González, A., Maldonado-Pérez, N., Gutierrez-Guerrero, A., Cortijo-Gutierrez, M., Ramos-Hernández, I., Tristán-Manzano, M., Galindo-Moreno, P., Herrera, C., & Martin, F. (2020). Genome-edited adult stem cells: Next-generation advanced therapy medicinal products. Stem Cells Translational Medicine, 9(6), 674–685. doi.org/10.1002/sctm.19-0338 Chang, C. W., Lai, Y. S., Pawlik, K. M., Liu,…
Phillips Discusses Treatment Options for Early-Relapsed DLBCL
Tycel J. Phillips, MD (MODERATOR) Associate Professor, Division of Lymphoma Department of Hematology & Hematopoietic Cell Transplantation City of Hope Duarte, CA EVENT REGION Maryland; Virginia; Washington, DC PARTICIPANT LIST Xinting Fu, MD | Andrew Pham, MD | David Shin, MD | Sharon Yee, MD | Albert Dekker, MD |…
Beauchamp honored at symposium highlighting basic research by surgeon scientists | VUMC Reporter
From left, Mark Evers, MD; Seth Carp, MD; Robert Coffey, MD; Carmen Solórzano, MD; J. Joshua Smith, MD, PhD; Naji N. Abumrad, MD; Steven Leach, MD; and Paula Marincola Smith, MD, PhD, pose for a photo during the R. Daniel Beauchamp Memorial Symposium at Vanderbilt University Medical Center. Not pictured,…
A biobank of pediatric patient-derived-xenograft models in cancer precision medicine trial MAPPYACTS for relapsed and refractory tumors
Patient characteristics and PDX establishment Between February 2016 and July 2020, 787 pediatric, adolescent and young adult patients with recurrent or refractory malignancies were enrolled in the MAPPYACTS trial;2 756 (96%) patients and their parents consented to the optional ancillary study of preclinical model development (Fig. 1a). 744 patients had a…
Novel Therapies Are Paving the Way to Better Patient Outcomes
This World Lymphoma Awareness Day, it’s important to remember that while the disease is increasingly more common, multiple novel therapies are available to better combat this disease. According to the National Institute of Health Surveillance, Epidemiology, and End Results (SEER) program, the estimated number of new cases of non-Hodgkin lymphoma…
CircRNA PGAM1 Promotes the Migration and Invasion of Pancreatic Adenocarcinoma Cells by Activating the AKT/mTOR Signaling Pathway
Atay, S. (2020). Integrated transcriptome meta-analysis of pancreatic ductal adenocarcinoma and matched adjacent pancreatic tissues. PeerJ, 8, e10141. Article PubMed PubMed Central Google Scholar Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., Global Cancer Statistics, et al. (2021). GLOBOCAN estimates of incidence and mortality worldwide…
Novel protein products encoded by upstream open reading frames of the MYCN gene in pediatric embryonal tumors
The MYCC and MYCN loci are each associated with two upstream open reading frames (uORFs) potentially encoding small proteins (9-21 kDa). We previously demonstrated that uORFs mrtl and MYCHEX1 of MYCC are translated, and their protein products may function to regulate the expression of the “parent” oncogene. We hypothesized that…
CCDC50, an essential driver involved in tumorigenesis, is a potential severity marker of diffuse large B cell lymphoma
Data collection and bioinformatic analysis GSE10846, GSE19246, GSE32918, GSE50721, GSE64820, and GSE94669, were downloaded from the Gene Expression Omnibus database (www.ncbi.nlm.nih.gov/geo/). DLBCL datasets from the GEPIA (Gene Expression Profiling Interactive Analysis) (gepia.cancer-pku.cn) and the TCGA (The Cancer Genome Atlas) (xenabrowser.net/datapages/) were also used in this study. A total of 284…
The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development
FBXW7 is a critical regulator of cell cycle, cell signaling, and development. A highly conserved F-box protein and component of the SKP1-Cullin-F-box (SCF) complex, FBXW7 functions as a recognition subunit within a Cullin-RING E3 ubiquitin ligase responsible for ubiquitinating substrate proteins and targeting them for proteasome-mediated degradation. In human cells,…
Fixed-Duration Data Foreshadow Earlier Use of Loncastuximab Tesirine in Relapsed/Refractory DLBCL
Blood Cancer © laszlo – stock.adobe.com Loncastuximab tesirine-lpyl (Zynlonta) plus rituximab (Rituxan; Lonca-R) demonstrated promising antitumor activity and consistent safety signals in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL), according to updated data from the phase 3 LOTIS-5 trial (NCT04384484) that were presented at the 2023 SOHO Annual Meeting.1…
Distinct N7-methylguanosine profiles of circular RNAs in drug-resistant acute myeloid leukemia
Drug-resistant AML cells display distinct cytogenetic and molecular characteristics, mainly resulting from the deletion or activation of multiple pathways associated with drug resistance3. A key contributor to drug resistance in cancer is m7G, which is recognized as a specific type of methylation pathway10. Notably, the quantity of m7G sites in…
Role of Super-Enhancers in Triggering Pancreatic Cancer Tumor Growth Explored in Study
NEW YORK — Researchers have identified how gene regulatory regions called super-enhancers can fuel the growth of pancreatic ductal adenocarcinoma (PDAC), which accounts for over 90 percent of all pancreatic cancer cases. In a study published in Nature Communications on Wednesday, a team led by researchers from the Salk Institute…
Patient with DLBCL involving the breast, spleen, and bone
Introduction The prevalence of any breast malignancy is very low in the male population, and male breast diffuse large B-cell lymphoma (DLBCL) is even rarer. Male breast cancer accounts for about 1% of all breast malignancies.1 Moreover, primary DLBCL of the breast accounts for only about 0.5% of breast tumors;2–4…
Cell-free DNA chromosome copy number variations predict outcomes in plasma cell myeloma
Testing for measurable residual disease (MRD) in persons with plasma cell myeloma (PCM) after therapy correlates with therapy outcomes including progression-free survival (PFS) and survival (reviewed in refs. [1, 2]). Most MRD-testing in this setting uses multi-parameter flow cytometry (MPFC) but prediction accuracy is imperfect with C-statistics of only about…
FBXW7 in breast cancer: mechanism of action and therapeutic potential
Review doi: 10.1186/s13046-023-02767-1. Affiliations Expand Affiliations 1 Chongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosisand, Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine, College of Medical Technology , Chengdu University of Traditional Chinese Medicine, Chengdu, China. 2 Chongqing Key Laboratory of Sichuan-Chongqing Co-Construction for Diagnosisand, Treatment of Infectious…
MYC Protein Overexpression May Be a Predictor of Poor Prognosis in DLBCL
The overexpression of MYC protein is a predictor of poor prognosis in patients with bulky mass diffuse large B-cell lymphoma (DLBCL), according to a new study published in the journal Cancer Medicine. This is especially the case for patients in the high-risk group and those with the germinal center B-cell–like…
SUMOylation of SMAD4 by PIAS1 in Conjunction with Vimentin Upregulation Promotes Migration Potential in Non-Small Cell Lung Cancer
1. Introduction Lung cancer is the most common cancer globally, with 2.21 million cases in 2020 and over 1.8 million deaths from lung cancer, making it the most common cause of cancer-related deaths [1]. In China, the estimated age-standardized incidence rate of lung cancer is as high as 34.8 per…
MYC overexpression but not MYC/BCL2 double expression predicts survival in bulky mass diffuse large B-cell lymphoma patients
Purpose: The prognostic factors for diffuse large B-cell lymphoma (DLBCL) have been fully explored, but prognostic information for bulky mass DLBCL patients is limited. This study aimed to analyze the prognostic value of MYC protein expression and other biological parameters in bulky mass DLBCL patients. Methods: We defined a bulky…
Polatuzumab Vedotin Demonstrates Tolerable Safety Profile in Aggressive LBCLs
“With [certain] notable exceptions, the safety profile of [polatuzumab vedotin plus dose-adjusted EPCH-R] appears comparable to previously published reports of EPOCH-R and much improved over the previous effort to combine a novel agent (venetoclax) with an intensive upfront regimen,” according to the authors of a phase 1 study (NCT04231877). Polatuzumab…
Analysis of endoplasmic reticulum stress-related gene signature for the prognosis and pattern in diffuse large B cell lymphoma
Swerdlow, S. H. et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127, 2375–2390 (2016). Article CAS PubMed PubMed Central Google Scholar Sehn, L. H. & Salles, G. Diffuse large B-cell lymphoma. N. Engl. J. Med. 384, 842–858 (2021). Article CAS PubMed PubMed Central …
Cells | Free Full-Text | The Highs and Lows of FBXW7: New Insights into Substrate Affinity in Disease and Development
From yeast to humans, FBXW7 proteins share three conserved domains: a dimerization domain required for interaction of two FBXW7 protomers, an F-box domain that mediates FBXW7 interaction with SKP1, and a substrate-binding domain composed of eight WD40 repeats (Figure 1A). The human FBXW7 gene permits expression of three isoforms that…
The non-classical major histocompatibility complex II protein SLA-DM is crucial for African swine fever virus replication
Cell lines and viruses Cell lines were received from the cell culture collection for veterinary medicine (CCVM) of the Friedrich-Loeffler-Institut (FLI). The highly passaged wild boar lung cell line (WSL-R-HP, #1346; abbreviated as WSL) was maintained in Ham’s F12 cell culture medium (Ham’s F-12, 5.32 g/L; IMDM, 8.80 g/L; NaHCO3, 2.45 g/L; pH 7.2)…
A Novel Method Transforms Human Skin Cells Into Pluripotent Stem Cells
Description Researchers from the Indian Institute of Technology (IIT) Guwahati and the Christian Medical College in Vellore have successfully devised a technology for transforming ordinary human skin cells into pluripotent stem cells known as Induced Pluripotent Stem Cells (iPSCs). Unlike traditional procedures that involve collecting stem cells from embryos or…
Genome-wide analysis and characterization of the LRR-RLK gene family provides insights into anthracnose resistance in common bean
Identification of PvLRR-RLK genes From the kinome of P. vulgaris30, 1203 PKs were identified. Of these, only the proteins endowed with the transmembrane kinase and LRR domains were retained (Supplementary Table S1). All PvLRR-RLKs obtained were analyzed for redundancy following the criterion of maintaining the largest variants in the case…
Breakthrough Method Converts Human Skin Cells into Pluripotent Stem Cells
August 18, 2023 Researchers from the Indian Institute of Technology (IIT) Guwahati and Christian Medical College, Vellore, have successfully developed a technique to transform regular human skin cells into pluripotent stem cells, known as Induced Pluripotent Stem Cells (iPSCs). Unlike conventional methods that involve extracting stem cells from embryos or…
Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers
Saito T, Niida A, Uchi R, Hirata H, Komatsu H, Sakimura S, et al. A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer. Nat Commun. 2018;9:2884. Article PubMed PubMed Central Google Scholar Uchi R, Takahashi Y, Niida A, Shimamura T, Hirata H, Sugimachi K, et al….
Researchers At IIT Guwahati Produces Pluripotent Stem Cells From Skin Cells
Researchers At IIT Guwahati Produces Pluripotent Stem Cells From Skin Cells | IANS Guwahati: Researchers from the Indian Institute of Technology (IIT) Guwahati in collaboration with scientists from Christian Medical College, Vellore, have reported a method to convert regular human skin cells into pluripotent stem cells. Explaining the basics of…
Skin Cells Transformed Into Pluripotent Stem Cells For Regenerative Therapy
IIT Guwahati Leads in Producing Pluripotent Stem Cells from Skin Cells GUWAHATI, August 16, 2023: In a monumental stride for regenerative medicine, a collaborative research effort led by the Indian Institute of Technology Guwahati (IITG) has successfully transformed regular human skin cells into pluripotent stem cells. Spearheaded by Dr. Rajkumar…
Multi institutional team led by IIT Guwahati produces pluripotent stem cells from skin cells
Researchers from the Indian Institute of Technology Guwahati (IITG) in collaboration with scientists from Christian Medical College, Vellore, have reported a method to convert regular human skin cells into pluripotent stem cells. “The human body is made of many kinds of cells – nerve cells, heart cells, liver cells, pancreatic…
Multiply Relapsed Secondary CNS Non-Germinal Center
Introduction Secondary central nervous system diffuse large B-cell lymphoma (SCNS-DLBCL) represents central nervous system (CNS) dissemination and involvement by a systemic DLBCL at the time of initial diagnosis (de novo SCNSL; DN-SCNSL) or relapse (R-SCNSL).1–6 R-SCNSL include CNS-only or concomitant CNS-systemic relapse. R-SCNSL develops early in the disease course with…
Detection of Oxidatively Modified Base Lesion(s) in Defined DNA Sequences by FLARE Quantitative PCR
Radak Z, Boldogh I (2010) 8-Oxo-7,8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress. Free Radic Biol Med 49(4):587–596 CrossRef CAS PubMed PubMed Central Google Scholar Steenken S (1989) Structure, acid/base properties and transformation reactions of purine radicals. Free Radic Res Commun 6(2–3):117–120 CrossRef CAS PubMed Google Scholar …
The progress of novel strategies on immune-based therapy in relapsed or refractory diffuse large B-cell lymphoma
Susanibar-Adaniya S, Barta SK. 2021 Update on diffuse large B cell lymphoma: a review of current data and potential applications on risk stratification and management. Am J Hematol. 2021;96:617–29. Article PubMed PubMed Central Google Scholar Rovira J, Valera A, Colomo L, Setoain X, Rodriguez S, Martinez-Trillos A, et al. Prognosis…
NCCN B-cell lymphoma welcomes another update! New treatment options for diffuse large B-cell lymphoma!
The content of the guide interpretation column is continuously updated every week, and popular & new guides are selected for interpretation for everyone to learn. The NCCN clinical practice guidelines for B-cell lymphoma ushered in the latest version 2023.V4. Compared with the 2023.V3 version, this updated version mainly involves the…
Calcineurin-mediated dephosphorylation enhances the stability and transactivation of c-Myc
In this study, by performing comprehensive gene expression analysis, we found that intracellular Ca2+ activates c-Myc target genes, and elucidated the molecular mechanism of this activation. Ca2+ signaling triggers intracellular biochemical responses by activating various calcium-binding proteins such as calmodulin, calcineurin, and CAMKII. We demonstrated that intracellular Ca2+ concentration modulates…
ncRNA | Free Full-Text | Investigation into the Role of Long-Non-Coding RNA MIAT in Leukemia
1. Introduction Recent advances in RNA-based approaches and Next Generation Technologies have unveiled the existence of non-coding RNAs (ncRNA), transcripts that lack the ability to code for proteins [1,2]. ncRNAs typically lack an open reading frame (ORF) and are subdivided into housekeeping and regulatory transcripts. Housekeeping ncRNAs are usually 50–500…