Tag: NfL

Pictured: shRNA sense and antisense sequences/iStock, Love Employee The recent FDA approval of Biogen’s Qalsody for superoxide dismutase 1 (SOD1)–ALS highlighted the potential for antisense oligonucleotides in central nervous system diseases. But the recent failure of Wave Life Sciences’ WVE-004 in C9orf72–ALS also showed their limitations. Antisense oligonucleotides (ASOs) are…

An early clinical trial headed by researchers at Keio University School of Medicine has shown that the Parkinson’s disease drug ropinirole is safe to use in patients with the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), and delayed disease progression by an average of 27.9 weeks. The study demonstrated…

TOKYO, Japan — A new study reveals that a common drug for treating Parkinson’s disease, ropinirole, can effectively slow the progression of amyotrophic lateral sclerosis (ALS) for over six months. ALS, which has claimed the lives of countless people, including renowned cosmologist Stephen Hawking, gradually causes people to lose muscle…

New data, being presented in a late-breaking session at the 2023 Consortium of Multiple Sclerosis Centers (CMSC) annual meeting, demonstrate that frexalimab, Sanofi’s novel second-generation investigational anti-CD40L antibody, with a unique mechanism of action, significantly reduced disease activity in a phase 2 trial of patients with relapsing multiple sclerosis (MS). …

This week, New York Giants head coach Brian Daboll began his second round of organized team activities (OTAs) with the team. There’s a big difference in the air from this time last year when everything and almost everyone was new to one another and their surroundings. The Giants entered Phase…

The Pittsburgh Steelers were back on the field for Organized Team Activities (OTAs) Wednesday, and for those who haven’t been paying attention this isn’t breaking news. The Steelers have been participating in OTAs for the last few months, but Phase 3, which just started, gets the most news. In case…

The Pittsburgh Steelers were back on the field for Organized Team Activities (OTAs) Tuesday, and for those who haven’t been paying attention this isn’t breaking news. The Steelers have been participating in OTAs for the last few months, but Phase 3, which just started, gets the most news. In case…

This week, the New Orleans Saints will begin “Phase 3” of their voluntary offseason workout programs. The Saints will hold organized team activities (OTA’s) starting today, Tuesday, May 23rd-Thursday May 25th. They will also hold OTA’s on Tuesday, May 30th-Thursday, June 1st and Monday, June 5th-Thursday, June 8th. There will…

“As a coach, you want them all here, all the time,” Saleh said. “Just felt like for him, he’s a very smart individual, very deep and very thoughtful. Personally, and I don’t know if it’s the right thing to say, I was never worried about whether or not he was…

The Detroit Lions are ready to kick off the third phase of the NFL offseason as they commence their OTAs (Other Team Activities) this week. These non-contact practice sessions will take place on Tuesday, Wednesday, and Thursday at the team’s facility in Allen Park. As the team enters this crucial…

On Monday, 20 NFL teams — including the Kansas City Chiefs — will begin Phase Three of their offseason programs. During Phase Three, teams may conduct a total of 10 days of voluntary organized team practice activity, or “OTAs”. No live contact is permitted, but 7-on-7, 9-on-7, and 11-on-11 drills…

My current solution is to “reverse forward ssh-agent” from worker node to login node: if [[ $(hostname) == login* ]] ; then echo ‘Welcome to login node’ export LOGIN_NODE_NAME=$HOSTNAME else echo ‘Welcome to job node’ ssh -NfL ~/.ssh/$(hostname).sock:$SSH_AUTH_SOCK -o ‘StreamLocalBindUnlink=yes’ -o ‘ExitOnForwardFailure=yes’ $LOGIN_NODE_NAME export SSH_AUTH_SOCK=~/.ssh/$(hostname).sock ssh-add -L >/dev/null 2>&1 &&…

When environmental activists talk about trucking, they often talk about diesel fumes spewed faceless corporations and hurting, maybe even killing, innocent children. As such, the level of their opposition to the trucking industry, to the fossil fuels industries, or to any of the carbon-intensive businesses that make American life possible…

As the NFL offseason moves on, here is the Detroit Lions OTA and minicamp schedule. There’s never much of an offseason in the NFL, with some teams having their rookie minicamps this coming weekend and voluntary offseason work having started in April. The Detroit Lions aren’t one of them who…

As the second round of the 2023 NFL draft continued to move, the New England Patriots stayed home. The war room in Foxborough did so to select Georgia Tech defensive lineman Keion White at No. 46 overall. White would become the fourth edge prospect to leave the board around the…

The U.S. Food and Drug Administration (FDA) has approved Biogen’s QALSODY (tofersen) 100 mg/15mL injection for the treatment of amyotrophic lateral sclerosis (ALS) in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene.  This indication is approved under accelerated approval based on reduction in plasma neurofilament light…

26 Apr 2023 The U.S. Food and Drug Administration has approved tofersen for the treatment of ALS. Developed originally by Ionis Pharmaceuticals and evaluated in clinical trials by Biogen, the antisense oligonucleotide (ASO) targets expression of superoxide dismutase 1. About 2 percent of people with ALS carry pathogenic variants in…

This transcript is provided for the convenience of investors only, for a full recording please see the Q1 2023 Earnings Call webcast. Alphabet Q1 2023 Earnings Call April 25, 2023 Operator: Welcome, everyone. Thank you for standing by for the Alphabet first quarter 2023 earnings conference call….

Alphabet Inc. (NASDAQ:GOOG) Q1 2023 Earnings Conference Call April 25, 2023 5:00 PM ET Company Participants Jim Friedland – Director, Investor Relations Sundar Pichai – Chief Executive Officer Philipp Schindler – Chief Business Officer Ruth Porat – Chief Financial Officer Conference Call Participants Brian Nowak – Morgan Stanley Doug Anmuth…

Easy web publishing from R. Write R Markdown documents in RStudio. Share them here on RPubs. (It’s free, and couldn’t be simpler!)Rpubs is an open publishing platform for HTML documents produced using RMarkdown from within RStudio, it provides a simple way to host and share your …Getting Started with RPubs. RStudio…

Because of safety concerns, the FDA has placed a partial clinical hold on the initiation of evobrutinib (EMD Serono), an investigational Bruton’s tyrosine kinase (BTK) inhibitor, in new patients and those with less than 70 days of exposure. EMD Serono noted that this decision does not impact the status of…

skralyx’s spirit animal Most of us have conflicted feelings about artificial intelligence.  Is it awesome, is it nefarious, or is it eerie?  Regardless, it is increasingly understood to be very powerful.  That’s been magnified recently in our everyday conversational lives with online tools like ChatGPT.  There really is no going…

The Trem2 R47H NSS mutation promotes loss of oligodendrocyte gene expression in response to cuprizone treatment. Results of previous studies of mice with the Trem2R47H missense mutation introduced via CRISPR suggested that it acts as a near-complete loss of function, recapitulating phenotypes seen in Trem2 knock-out (KO) mice [34, 36]….

Easy web publishing from R. Write R Markdown documents in RStudio. Share them here on RPubs. (It’s free, and couldn’t be simpler!)Rpubs is an open publishing platform for HTML documents produced using RMarkdown from within RStudio, it provides a simple way to host and share your …Getting Started with RPubs. RStudio…

​ Over 400 individuals participated in this year’s edition, a record high for the Big Data Bowl competition New York, NY (February 16, 2023) – The National Football League announced today the finalists for the fifth annual Big Data Bowl powered by Amazon Web Services (AWS). The annual sports analytics…

Image source: The Motley Fool. Alphabet (GOOGL -2.75%)Q4 2022 Earnings CallFeb 02, 2023, 4:30 p.m. ET Contents: Prepared Remarks Questions and Answers Call Participants Prepared Remarks: Operator Welcome, everyone. Thank you for standing by for the Alphabet fourth quarter 2022 earnings conference call. At this time, all participants are in a listen-only…

15 Jan 2023 Part 1 of 2The year 2022 was a turning point in Alzheimer’s research. It began with the Aduhelm debacle fresh on people’s mind. It ended with reassurance that amyloid removal indeed helps people with the disease, when lecanemab’s Phase 3 data showed a slowing of cognitive decline….

Transcribed image text: Use package ‘ggplot2’ to generate all the graplis in HW4. 1. Stock Prices: – Check out the yahoo webpage of historical stock price data for Netflix (NFLX): finance. yahoo.com/quote/NFL X/history? p=NFLX ). – Change the range of Date from 01/01/2021 to 09/30/2021. Click on “Apply” before “Download”….

Sports API is a network that allows two services and applications to give all data connected to sports across all matches, such as score updates, player details, match details, and rankings, Fantasy points, among other things. Sports APIs are multi-disciplinary, which means they may supply a wide range of sports-related…

NFL Player Aaron Rodgers has recently spoken in length about his relationship with actor Shailene Woodley, addressing how criticism of his COVID-19 vaccination status has affected his loved ones. According to The Hollywood Reporter, both stars confirmed their engagement last year, although some media outlets recently reported that the…

Blood levels of the protein neurofilament light chain (NFL), a biomarker of several neurological disorders, may not be suitable to measure outcomes in patients with Charcot-Marie-Tooth disease type 1A (CMT1A), a recent study suggests. The study, “A longitudinal and cross-sectional study of plasma neurofilament light chain concentration in Charcot-Marie-Tooth disease,”…

So I’m competing in the NFL Big Data Bowl hosted by Kaggle and I’m having trouble uploading both r script and rmd into kaggle. I keep getting parse errors that I can’t seem to get around. I’ve even tried copy pasting code from other peoples code from similar notebooks but…