Tag: NPC

Integrated multi-omics for rapid rare disease diagnosis on a national scale

Ethics The Australian Genomics Acute Care study has Human Research Ethics Committee approval (HREC/16/MH/251). Parents provided informed consent for participation in the study, following genetic counseling. Study design and participants The Acute Care Genomics program is a national multi-site study delivering ultra-rapid genomic testing to critically ill pediatric patients with…

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element_textbox function – RDocumentation

Usage element_textbox( family = NULL, face = NULL, size = NULL, colour = NULL, fill = NULL, box.colour = NULL, linetype = NULL, linewidth = NULL, hjust = NULL, vjust = NULL, halign = NULL, valign = NULL, lineheight = NULL, margin = NULL, padding = NULL, width = NULL,…

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protein abrupt-like isoform x1, maker-scaffold97_size377342-snap-gene-2.14 (gene) Tigriopus kingsejongensis

Associated RNAi Experiments Homology BLAST of protein abrupt-like isoform x1 vs. L. salmonis genes Match: EMLSAG00000011120 (supercontig:LSalAtl2s:LSalAtl2s753:207020:208693:1 gene:EMLSAG00000011120 transcript:EMLSAT00000011120 description:”augustus_masked-LSalAtl2s753-processed-gene-1.1″) HSP 1 Score: 342.043 bits (876), Expect = 1.286e-109Identity = 269/559 (48.12%), Postives = 311/559 (55.64%), Query Frame = 0 Query: 168 DNFGPSAPKRHRFNGPESRNSPSSSPKSLADWGRRSLEPKTEDTAEADNNNSTPKSESLLSQALEKHSNVSSMYDRHLLRDNGDGRDGDSASDTTSERPESLMDGLIKNSGAESELHRQLSAASPASMGGHLFPPGLEALYRQAGFPSAFLGLAAGAA—-GGSPGG————–PVSSMHGLASSVPQVGLQSHAGNPN—————————————–LAGKLDMMRVRATDPRPCPKCGKIYRSAHTLRTHMEDKHTICPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSPFDPALASRLLAKAGVKVTPNELAARASPTAPRRSDLPKLDTNLLHM-HHHQFPLPPSLPT-SMSGHMGRGSHDGNGSDVEDLRVSSAPSPFGSNGGPGGIYSQAHQMRIAQGMLSPKDFA–ALASAGGAQGAAGMGSALLDTYLSMI-AAAGGDSNPMAAALNFQ-NPASRAAAFAAAAAAASGNQAHNGDGKDNDQRSGVSEDRDDMTGELGSDADNDDLSDNDD 661 D++ P PKRHR NG E…

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Methanol fixation is the method of choice for droplet-based single-cell transcriptomics of neural cells

hiPSC cell culture and differentiation hiPSCs were maintained on 1:40 matrigel (Corning, #354277) coated dishes in supplemented mTeSR-1 medium (StemCell Technologies, #85850) with 500 U ml−1 penicillin and 500 mg ml−1 streptomycin (Gibco, #15140122). For the differentiation of cortical neurons the protocol described previously21 was followed with slight modifications. Briefly, hiPSC colonies were seeded…

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r – How to calculate the exponential equation in ggplot2?

I am trying to fit the exponential line to the points. It is working. But the linear formula appears in the diagram. I would appreciate someone telling me how to make the exponential formula in the plot. Nu treat pH Cd 1 Soil 6.1 0.28 2 Soil 6.1 0.29 3…

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r – ggplot2: Legend with barplot and line

One option would be to first add a linetype scale and legend. Doing so allows to keep the outline in the legend for the geom_bar while removing the line glyph. Removing the outline for the geom_line is more tricky. Haven’t found a way to do so via override.aes. So I…

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SUMOylation mediates the disassembly of the Smad4 nuclear export complex via RanGAP1 in KELOIDS

. 2023 Apr;27(8):1045-1055. doi: 10.1111/jcmm.17216. Epub 2023 Mar 14. Affiliations Expand Affiliations 1 Department of Plastic and Reconstructive Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China. 2 Ningbo Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, China. 3 Department of Plastic Surgery, The…

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IJMS | Free Full-Text | An Efficient 2D Protocol for Differentiation of iPSCs into Mature Postmitotic Dopaminergic Neurons: Application for Modeling Parkinson’s Disease

Received: 28 February 2023 / Revised: 31 March 2023 / Accepted: 5 April 2023 / Published: 14 April 2023 Round 1 Reviewer 1 Report The article written by Lebedeva and colleagues descrives a 2D protocol useful for the differentiation of iPSCs into mature postmitotic DA-neurons in feeder-free and integration-free conditions….

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Can This Medical Herb Help Fight Tumors?

Skullcap (Scutellaria barbata) has impressive antitumor properties, making it a potential treatment for chronic disease, in part due to its active ingredient scutebarbatine A. Story at a Glance Skullcap (Scutellaria barbata) is a traditional Chinese medicine (TCM) plant known in China as banzhilian. Researchers used DNA sequencing to uncover how…

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Epic Gems, Raids, Loots, Events & More Items

Now that we’re well into phase 2 of Wrath of the Lich Classic and if you want to take a look forward as to what will be coming up in phase 3, so today we’ll be checking out WOTLK Classic phase 3 release date, and what’s new what to expect…

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N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis

. 2023 Feb 16;30(2):144-158.e10. doi: 10.1016/j.chembiol.2023.01.006. Affiliations Expand Affiliations 1 Department of Breast Cancer, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, 106 Zhongshan Er Road, Yuexiu District, Guangzhou 510080, P.R. China; State Key Laboratory of Oncology in South China, Guangdong Key Laboratory of Nasopharyngeal Carcinoma…

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Junshi Biosciences Announces Toripalimab in Combination with Chemotherapy for Treatment of Advanced Triple-negative Breast Cancer Met Primary Endpoint in Phase 3 Clinical Study

This section is Partnership Content supplied The content in this section is supplied by GlobeNewswire for the purposes of distributing press releases on behalf of its clients. Postmedia has not reviewed the content. by GlobeNewswire Breadcrumb Trail Links GlobeNewswire Author of the article: Published Feb 20, 2023  •  Last updated…

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New Cell Culture, Analysis Approach Helps Explain Differences in Zika Virus Susceptibility

NEW YORK – A team led by researchers at the Broad Institute has demonstrated the potential of using so-called cell villages from several donors to characterize expression variability in neural progenitor cells (NPC), along with related genetic features that appear to influence brain function and vulnerability to Zika virus infection….

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Junshi Biosciences and Coherus Announce Positive Final Overall Survival Results of JUPITER-02, a Phase 3 Clinical Trial Evaluating Toripalimab as Treatment for Recurrent or Metastatic Nasopharyngeal Carcinoma

This section is Partnership Content supplied The content in this section is supplied by GlobeNewswire for the purposes of distributing press releases on behalf of its clients. Postmedia has not reviewed the content. by GlobeNewswire Breadcrumb Trail Links GlobeNewswire Article content – Final overall survival analysis of the JUPITER-02 trial…

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Fluorescent aptasensor based on the MNPs-CRISPR/Cas12a-TdT for the determination of nasopharyngeal carcinoma-derived exosomes

doi: 10.1007/s00604-023-05657-7. Affiliations Expand Affiliations 1 Department of Radiotherapy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, China. 2 Department of Pharmacy, Zigong Third People’s Hospital, Zigong, 643020, Sichuan, China. 3 Department of Otorhinolaryngology Head and Neck Surgery, Shenzhen Fuyong People’s Hospital, Shenzhen,…

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r – How can I make the legend color bar the same height as my plot panel?

The problem is that the plot panel does not have defined dimensions until drawing (“NULL unit”), but your legend guide has. See also npc coordinates of geom_point in ggplot2 or figuring out panel size given dimensions for the final plot in ggsave (to show count for geom_dotplot). I think it…

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ggplot2 – Adding horizontal title/label to bar charts in ggplot R

The default approach to achieve the kind of grouping would be via faceting, However, TBMK the default element_rect provided by ggplot2 does not offer the option to just draw a top line. One option would be to create a custom theme element to achieve that. To this end I adapted…

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circRNF13 Inhibits the Proliferation and Metastasis of Nasopharyngeal Carcinoma through SUMO2

Circular RNAs (circRNAs) are widely expressed in human cells and are closely related to the development of cancer. However, they are rarely studied in the context of nasopharyngeal carcinoma (NPC). Here, the researchers found that a novel circRNF13 was stably expressed at low levels in clinical tissues and cells of…

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Description, Programming Languages, Similar Projects of ggfx

ggfx is a (currently experimantal) package that allows the use of various filters and shaders on ggplot2 layers. Installation You can install ggfx from CRAN in the usual manner (install.packages(‘ggfx’)) or you can grab the development version directly from github using the devtools package: # install.packages(‘devtools’) devtools::install_github(‘thomasp85/ggfx’) Example The basic…

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Mechanism for DNA invasion of adenoviral Covi

image: Incoming adenovirus particles (AdV) dock at the nuclear pore complexes of a human cell’s nucleus (NPC, dashed line). The cellular enzyme Mind bomb1 (Mib1, grey-white structures) primes them for unlocking and removes protein V (GFP-V, green dots). The uncoated viral DNA genome is then imported into the nucleus. The arrow…

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ggplot, drawing multiple lines across facets

ggplot, drawing multiple lines across facets I drew two panels in a column using ggplot2 facet, and would like to add two vertical lines across the panels at x = 4 and 8. The following is the code: library(ggplot2) library(gtable) library(grid) dat <- data.frame(x=rep(1:10,2),y=1:20+rnorm(20),z=c(rep(“A”,10),rep(“B”,10))) P <- ggplot(dat,aes(x,y)) + geom_point() +…

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Using comm to make a list of files that haven’t yet been processed

Using comm to make a list of files that haven’t yet been processed 0 I’m using comm to work out which files have already been processed and which are still to do. The input and output filenames are a little different, so I’ve used basename and sed to strip away…

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gmod how to animate ragdolls

Now that you know nearly all the possibilities in this mod, let’s go even more deeper. Oct 15, 2019. Continue browsing in r/gmod. The original TF2 on the other hand is very easy to face pose, because you can literally move just 1 silder, and then you got a “happy…

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gmod animation commands

Intensity of magnade’s attraction to a hunter. Learn how your comment data is processed. Find key bound to specified command string. Insomnia65 August 12, 2019 – TF2 Team. if you find this, don’t go around enabling it and then complaining about issues. The “size in K” is the block size…

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gmod advanced duplicator 2

Advanced Duplicator 2 is a Garry’s Mod addon which implements a tool similar to the Duplicator, but with many added features. Yeah no problem mate, thanks for the response. I’m done with gmod and I don’t take requests, so please stop spamming the comment section. “Originally published in single magazine…

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gmod prop hunt not working

I’ve let the server stay open so you can join it and test for yourself. Game Garry’s Mod. It’s just textures (and maps, if you need it) for use as an addon to Garry’s Mod. From hunting down everyday objects in Prop Hunt to strangling and trampling pigs in Open…

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New Techniques and Complex Models

CRISPR systems that rely on inactivated Cas enzymes—that is, dead Cas (dCas) enzymes—never looked more alive. They harness the targeting power associated with CRISPR—but not the double-strand cuts. As such, they give researchers new ways to interrogate and manipulate gene function. Possibilities include CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa)…

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