Tag: Nucleosome

SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma

Clapier, C. R., Iwasa, J., Cairns, B. R. & Peterson, C. L. Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes. Nat. Rev. Mol. Cell Biol. 18, 407–422 (2017). CAS  PubMed  PubMed Central  Article  Google Scholar  Mashtalir, N. et al. Modular organization and assembly of SWI/SNF family chromatin remodeling complexes….

Continue Reading SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma

Prediction of histone post-translational modification patterns based on nascent transcription data

Allfrey, V. G., Faulkner, R. & Mirsky, A. E. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc. Natl Acad. Sci. USA 51, 786–794 (1964). CAS  PubMed  PubMed Central  Google Scholar  Ho, J. W. K. et al. Comparative analysis of metazoan chromatin organization….

Continue Reading Prediction of histone post-translational modification patterns based on nascent transcription data

Dissertations.se: CHIP-SEQ

Showing result 1 – 5 of 34 swedish dissertations containing the word ChIP-Seq. Author : Ola Wallerman; Claes Wadelius; Jussi Taipale; Uppsala universitet; []Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide;…

Continue Reading Dissertations.se: CHIP-SEQ

Q9Y265 | SWISS-MODEL Repository

Cryo-Em structure of the hexameric RUVBL1-RUVBL2 in complex with ZNHIT2 HeteromerQ9Y230; 3×ADP; 7p6x SMTL PDBe PDBe-KB PDBj PDBsum RCSB 1-456 Assess Truncated human R2TP complex, structure 3 (ADP-filled) HeteromerQ9Y230; 6×ADP; 6qi8 SMTL PDBe PDBe-KB PDBj PDBsum RCSB 2-456 Assess Truncated human R2TP complex, structure 4 (ADP-empty) HeteromerQ9Y230; 5×ADP; 6qi9 SMTL…

Continue Reading Q9Y265 | SWISS-MODEL Repository

RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder

Significance Hairpin pyrrole-imidazole (Py-Im) polyamides can be programmed to bind a broad repertoire of DNA sequences. Py-Im small molecules can be used to target cancer-specific coding regions and block transcription elongation. This transcription blockage by Py-Im cannot be rescued by transcription elongation factors, such as TFIIS. The mechanism by which…

Continue Reading RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder

An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes

Conflicting results suggest a missing variant In order to narrow down candidates for the causal genetic variant, we performed genome-wide association mapping separately in individual lake populations (previously, association mapping was only performed across the whole species flock5). Interestingly, despite clear association peaks in the crater lakes (Fig. 1a, b), the…

Continue Reading An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes

Louisiana Tech to host graduate webinar in multiscale genome research

Sept. 22, Louisiana Tech University will host a multiscale genome organization research webinar in which graduate students and postdoctoral researchers will share their work in the field. The webinar, which will begin at 10 a.m. Central Standard Time, will feature five speakers from universities around the world: Stephanie Protillo, a…

Continue Reading Louisiana Tech to host graduate webinar in multiscale genome research

3D-Beacons Network: protein structure data, all in one place

3D-Beacons Network acts as a one-stop shop for protein structures by combining and standardising data from several providers Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome. Image obtained from PDBe A new platform called 3D-Beacons Network brings together experimentally determined and predicted protein structure models and related…

Continue Reading 3D-Beacons Network: protein structure data, all in one place

MYO10 drives genomic instability and inflammation in cancer

INTRODUCTION Genomic instability often refers to the existence of a variety of DNA alterations, ranging from single nucleotide changes (such as base substitution, deletion, and insertion) to chromosomal rearrangements (e.g., gain or loss of a segment or the whole chromosome) (1). Loss of genome stability can lead to early onset…

Continue Reading MYO10 drives genomic instability and inflammation in cancer