Tag: Nucleosome
SMARCE1 deficiency generates a targetable mSWI/SNF dependency in clear cell meningioma
Clapier, C. R., Iwasa, J., Cairns, B. R. & Peterson, C. L. Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes. Nat. Rev. Mol. Cell Biol. 18, 407–422 (2017). CAS PubMed PubMed Central Article Google Scholar Mashtalir, N. et al. Modular organization and assembly of SWI/SNF family chromatin remodeling complexes….
Prediction of histone post-translational modification patterns based on nascent transcription data
Allfrey, V. G., Faulkner, R. & Mirsky, A. E. Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc. Natl Acad. Sci. USA 51, 786–794 (1964). CAS PubMed PubMed Central Google Scholar Ho, J. W. K. et al. Comparative analysis of metazoan chromatin organization….
Dissertations.se: CHIP-SEQ
Showing result 1 – 5 of 34 swedish dissertations containing the word ChIP-Seq. Author : Ola Wallerman; Claes Wadelius; Jussi Taipale; Uppsala universitet; []Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide;…
Q9Y265 | SWISS-MODEL Repository
Cryo-Em structure of the hexameric RUVBL1-RUVBL2 in complex with ZNHIT2 HeteromerQ9Y230; 3×ADP; 7p6x SMTL PDBe PDBe-KB PDBj PDBsum RCSB 1-456 Assess Truncated human R2TP complex, structure 3 (ADP-filled) HeteromerQ9Y230; 6×ADP; 6qi8 SMTL PDBe PDBe-KB PDBj PDBsum RCSB 2-456 Assess Truncated human R2TP complex, structure 4 (ADP-empty) HeteromerQ9Y230; 5×ADP; 6qi9 SMTL…
RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder
Significance Hairpin pyrrole-imidazole (Py-Im) polyamides can be programmed to bind a broad repertoire of DNA sequences. Py-Im small molecules can be used to target cancer-specific coding regions and block transcription elongation. This transcription blockage by Py-Im cannot be rescued by transcription elongation factors, such as TFIIS. The mechanism by which…
An intronic transposon insertion associates with a trans-species color polymorphism in Midas cichlid fishes
Conflicting results suggest a missing variant In order to narrow down candidates for the causal genetic variant, we performed genome-wide association mapping separately in individual lake populations (previously, association mapping was only performed across the whole species flock5). Interestingly, despite clear association peaks in the crater lakes (Fig. 1a, b), the…
Louisiana Tech to host graduate webinar in multiscale genome research
Sept. 22, Louisiana Tech University will host a multiscale genome organization research webinar in which graduate students and postdoctoral researchers will share their work in the field. The webinar, which will begin at 10 a.m. Central Standard Time, will feature five speakers from universities around the world: Stephanie Protillo, a…
3D-Beacons Network: protein structure data, all in one place
3D-Beacons Network acts as a one-stop shop for protein structures by combining and standardising data from several providers Cryo-EM structure of the BRCA1-UbcH5c/BARD1 E3-E2 module bound to a nucleosome. Image obtained from PDBe A new platform called 3D-Beacons Network brings together experimentally determined and predicted protein structure models and related…
MYO10 drives genomic instability and inflammation in cancer
INTRODUCTION Genomic instability often refers to the existence of a variety of DNA alterations, ranging from single nucleotide changes (such as base substitution, deletion, and insertion) to chromosomal rearrangements (e.g., gain or loss of a segment or the whole chromosome) (1). Loss of genome stability can lead to early onset…
