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Tag: pA
Genomic insights into Plasmodium vivax population structure and diversity in central Africa | Malaria Journal
Hamblin MT, Di Rienzo A. Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus. Am J Hum Genet. 2000;66:1669–79. Article CAS PubMed PubMed Central Google Scholar Hamblin MT, Thompson EE, Di Rienzo A. Complex signatures of natural selection at the Duffy blood group…
Multiple Job openings at Gujarat Biotechnology Research Centre
Government of Gujarat has established Gujarat State Biotechnology Mission (GSBTM) as a nodal agency to develop overall development of biotechnology in the state in 2004. Major activities of GSBTM is promoting research and development in the field of biotechnology and supporting the development of biotechnology industries in the state. Besides…
PA in Director’s Office – EMBL-EBI
PA in Director’s Office EMBL-EBI – European Bioinformatics Institute Hinxton, United Kingdom Organisation data: Directors OfficeJob Number: EBI02200Contract Type: Staff MemberAdvertised Grade-Grading: Grade 5 – 6 (depending on experience) Monthly salary from £3,090 – £3,456 after tax – other benefits based on family circumstancesContract Duration-Length of Time (years/months): 3 years…
Oculis Announces First Patient First Visit In Phase 3 OPTIMIZE-2 Trial Of OCS-01 For The Treatment Of Inflammation And Pain Following Cataract Surgery
(MENAFN– GlobeNewsWire – Nasdaq) Initiation of the second Phase 3 OPTIMIZE-2 trial with OCS-01 once daily eye drop, follows the recently reported positive OPTIMIZE-1 trial results OPTIMIZE-2 topline readout expected before end of 2024 to support NDA submission OCS-01 is also being evaluated as potentially the first topical eye drop…
European Bioinformatics Institute | EMBL-EBI hiring PA in Director’s Office in Hinxton, England, United Kingdom
Join our dynamic team as a Personal Assistant, providing top-notch administrative and organisational support within the EMBL-EBI Directors’ Office to the EMBL-EBI Joint Director; the Hinxton-based EMBL Head of Human Resources; and the Hinxton-based EMBL Head of Strategy. If you’re an experienced and proactive Personal Assistant, excited to contribute to…
Start Of Patient Dosing In Early Cardiogenic Shock SEISMiC Extension Study In Preparation For Phase 3 Readiness, Topline Data Expected Mid-2024
WARRINGTON, PA / ACCESSWIRE / December 19, 2023 / Windtree Therapeutics, Inc. (NASDAQ: WINT) has recently enrolled the first subject in its phase 2 SEISMiC Extension Study to evaluate istaroxime in the treatment of early cardiogenic shock. The phase 2 trial builds upon the positive data from the SEISMiC study…
Validation of Oxford nanopore sequencing for improved New World Leishmania species identification via analysis of 70-kDA heat shock protein | Parasites & Vectors
Akhoundi M, Downing T, Votypka J, Kuhls K, Lukes J, Cannet A, et al. Leishmania infections: molecular targets and diagnosis. Mol Aspects Med. 2017;57:1–29. Article PubMed Google Scholar Akhoundi M, Kuhls K, Cannet A, Votypka J, Marty P, Delaunay P, et al. A historical overview of the classification, evolution, and…
Q&A: Why Small Organisms Can Make Big Impacts
UNIVERSITY PARK, Pa. — This week, representatives from nearly 200 countries reached an agreement at the COP28 climate summit in Dubai to begin reducing global consumption of fossil fuels in efforts to reduce carbon emissions and stave off the worst-case scenarios of climate change. Mary Ann Bruns, Penn State professor…
A STING Operation in neuroendocrine neoplasms | NANETS2023 | NANETS 2023
1Huntsman Cancer Institute, University of Utah, Salt Lake City, UT; 2University of Minnesota, Minneapolis, MN; 3Caris Life Sciences, Phoenix, AZ; 4The Ohio State University, Columbus, OH; 5Fox Chase Cancer Center, Philadelphia, PA; 6Sylvester Cancer Center, University of Miami, Miami, FL; 7Brown University, Providence, RI Background: Significant advances have been made…
Verrica Pharmaceuticals Announces Positive Results from Phase 3 Trial of TO-208 for Molluscum Treatment in Japan
WEST CHESTER, PA — Verrica Pharmaceuticals Inc. (Nasdaq: VRCA), a leading dermatology therapeutics provider, has shared promising top-line results from the Phase 3 trial of TO-208 for molluscum contagiosum (“molluscum”) treatment in Japan. The trial was conducted by Torii Pharmaceutical Co., Ltd., Verrica’s development and commercialization partner. The double-blind, randomized,…
First report of cutaneous leishmaniasis caused by Leishmania donovani in Ethiopia | Parasites & Vectors
Alvar J, Vélez ID, Bern C, Herrero M, Desjeux P, Cano J, et al. Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE. 2012. doi.org/10.1371/journal.pone.0035671. Article PubMed PubMed Central Google Scholar Gadisa E, Tsegaw T, Abera A, Elnaiem DE, Den Boer M, Aseffa A, et al. Eco-epidemiology of visceral…
Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample. Proceedings of the national academy of sciences 2011, 108(Supplement 1):4516-4522.
1The Nelson Mandela African Institution of Science and Technology, P.O. Box 447, Arusha, Tanzania 2BecA-ILRI Hub International Livestock Research Institute, P. O. Box 30709, Nairobi, Kenya 3Departments of Biochemistry and Molecular Biology, W238A Millennium Science Complex University Park, PA 16802, Penn State University, USA 4Huck Institutes of Life Sciences, Department…
extracting instruments for mendelian randomization analysis
extracting instruments for mendelian randomization analysis 0 Cross-posted on bioinfo SE: bioinformatics.stackexchange.com/questions/21952/extracting-instruments-for-mendelian-randomization-analysis I am looking at extracting genetic variants associated with physical activity (to be used as exposure) from gwas id ebi-a-GCST006097. The gwas has nsnp = 11808007 library(TwoSampleMR) library(ieugwasr) gwasinfo (“ebi-a-GCST006097”) However, when I extract this, I end up…
Identification of Differentially Expressed Genes in Human Colorectal Cancer Using RNASeq Data Validated on the Molecular Level with Real-Time PCR
Allam RM, Al-Abd AM, Khedr A, Sharaf OA, Nofal SM, Khalifa AE, Mosli HA, Abdel-Naim AB (2018) Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells. Toxicol Lett 291:77–85 Article CAS PubMed Google Scholar Andrews S et al (2010) FastQC: a quality control tool…
Verrica Pharmaceuticals’ Development and Commercialization
WEST CHESTER, Pa., Dec. 15, 2023 (GLOBE NEWSWIRE) — Verrica Pharmaceuticals Inc. (“Verrica” or “the Company”) (Nasdaq: VRCA), a dermatology therapeutics company developing medications for skin diseases requiring medical interventions, today announced that its development and commercialization partner, Torii Pharmaceutical Co., Ltd. (“Torii”), reported positive top-line results from its Phase…
Increasing Widespread Accessibility of Molecular Testing for Oncology Research
Advancements in cancer diagnostics and monitoring have revolutionized the way we understand and treat this complex disease. The advent of molecular technologies for analyzing nucleic acids has made it possible to detect, analyze and monitor cancer more precisely and sensitively than ever before. Furthermore, it has made noninvasive liquid biopsy…
U.S. Neurologists Eagerly Await Promising Oral Bruton’s Tyrosine Kinase Inhibitors in Multiple Sclerosis Treatment Pipeline, Though Recent Trial Readouts Might Hamper Initial Excitement
Efficacy and safety of pipeline multiple sclerosis assets viewed as increasingly important characteristics, according to Spherix Global Insights. Exton, PA, Dec. 13, 2023 (GLOBE NEWSWIRE) — Several clinical trials are underway for Bruton’s tyrosine kinase inhibitors (BTKi) targeting relapsing and progressive multiple sclerosis (RMS/PPMS). These BTKis, administered orally, possess the…
Bioactive glycans in a microbiome-directed food for children with malnutrition
Collection and handling of biospecimens obtained from participants in the randomized controlled clinical study of the efficacy of MDCF-2 The human study entitled ‘Community-based clinical trial with microbiota-directed complementary foods (MDCFs) made of locally available food ingredients for the management of children with primary moderate acute malnutrition (MAM)’ was approved…
Ipswich Town (A) – SAFC
Ticketing information has been confirmed for Sunderland AFC’s first away trip of 2024. The Lads visit Portman Road to take on high-flying Ipswich Town on Saturday 13 January, kicking off at 5:30pm. Cobbold Stand Upper Tier pricing can be found below: Adults: £34 Seniors Aged 65+: £27Under…
High-throughput sequencing of Diatoms using V4 region of 18S rRNA gene in Bayug Island, Iligan City, Philippines
Almarez DN, Almarez FJS, Baulete EM. 2014. Bayug Island Aquasilvi Program: An Eco-Governance Strategy for Climate Change Adaptation and Mitigation. J Govern Dev 10(2): 35-54. DOI: 10.32890/jgd. Alongi DM. 2014. Carbon cycling and storage in mangrove forests. Ann Rev Mar Sci 6: 195-219. DOI: 10.1146/annurev-marine-010213-135020. Balint M, Pfenninger M, Grossart…
Analysis of geometric morphometrics and molecular phylogeny for Anopheles species in the Republic of Korea
World Health Organization (WHO). WHO malaria report. 2022 www.who.int/publications/i/item/9789240064898 (2022). Savi, M. K. An overview of malaria transmission mechanisms, control, and modeling. Med. Sci. 11, 3 (2023). Google Scholar Bahk, Y. Y. et al. Epidemiological characteristics of re-emerging vivax malaria in the Republic of Korea (1993–2017). Korean J. Parasitol. 56,…
Wide bovine tick-borne pathogen spectrum: Predominancy of Theileria annulata and the first molecular detection of Ehrlichia minasensis in Turkey
Agina OA, Shaari MS, Isa NMM, Ajat M, Zamri-Saad M, Hamzah H (2020) Clinical pathology, immunopathology and advanced vaccine technology in bovine theileriosis: A review. Pathogens 9:697. doi.org/10.3390/pathogens9090697 Article PubMed PubMed Central CAS Google Scholar Aktas M (2014) A survey of ixodid tick species and molecular identification of tick-borne pathogens….
STWOA Success | News, Sports, Jobs
Southwestern’s Tavio Hoose works on top of St. Francis’ Zachary Caldwell during the 190-pound final at the Southern Tier Wrestling Officials Association Tournament on Saturday at Jamestown Community College’s Physical Education Complex. Hoose won 8-1. Photo courtesy of Shelly Phillips The Southern Tier Wrestling Officials Association Kickoff Classic featured plenty…
Suicide Cleanup in Pittsburgh, Carnegie, Oakdale, McMurray, Beaver, Sturgeon, PA
Odor Abatement Decaying human remains will typically give off distinct and very unpleasant odors. That’s why every unattended death cleanup includes our custom odor abatement service. The DASH Bio-Recovery experts use advanced technology and methods to not just mask odors but remove them. These deodorizing and removal techniques include the…
University of Southern Queensland hiring Research Fellow (Bioinformatics) in Toowoomba, Queensland, Australia
Building on its strengths as Australia’s leading regional University, UniSQ’s vision is to be renowned for innovation and excellence in education, student experience, research and engagement. Guided by our core values of respect, integrity and excellence, the University’s Strategic Plan 2021-2025 outlines our commitment to creating and sharing knowledge, transforming…
Analyses Probe into Co-Mutation Activity of Sotorasib in KRAS-Mutant NSCLC
Devika Das, MD Associate Professor UAB Medicine Birmingham, AL LINK TO PART 1 Targeted Oncology: What data support the use of sotorasib (Lumakras) in patients with non–small cell lung cancer (NSCLC) and a KRAS G12C mutation? DEVIKA DAS, MD: The CodeBreaK 100 study [NCT03600883] was a registrational phase 2 study….
Agricultural Genomic Market Share & Market New Trends Analysis Report By Type, By Application, By End-use, By Region, And Segment Forecasts, 2023 – 2030
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By Alex Philippidis At the start of 2023, the website for Pfizer CenterOne posted an article titled, “What Trends Will Shape the Pharma and Biotech Industries in 2023?” It quoted Rick L. Knight, the company’s global head of strategic account management, as follows: “We can continue to expect to see…
Sangers Sequencing Service Market Furnish Information about Market Size, Market Share, Market Dynamics, and Projections Spanning from 2023 to 2030.
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Parte AC, Sardà Carbasse J, Meier-Kolthoff JP, Reimer LC, Göker M. List of Prokaryotic names with standing in nomenclature (LPSN) moves to the DSMZ. Int J Syst Evol Microbiol. 2020;70:5607–12. Article PubMed PubMed Central Google Scholar Saxena AK, Kumar M, Chakdar H, Anuroopa N, Bagyaraj DJ. Bacillus species in soil…
Walmart, Aldi, Sprouts, others received fruit linked to deadly Listeria outbreak
More details have become available abut recalled peaches, plums and nectarines linked to a deadly outbreak of infections from Listeria monocytogenes. Eleven people from coast to coast have been sickened with one reported dead and the other 10 hospitalized. Whole genome sequencing linked the patients together using DNA fingerprints of…
Molecular complexity of diffuse large B-cell lymphoma: a molecular perspective and therapeutic implications
Agarwal P, Kabir FM, DeInnocentes P, Bird RC (2012) Tumor suppressor gene p16/INK4A/CDKN2A and its role in cell cycle exit, differentiation, and determination of cell fate. Tumor Suppressor Genes 3(10):27882 Google Scholar Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E et al (2022) The 5th edition…
Development and evaluation of specific polymerase chain reaction assays for detecting Theileria equi genotypes | Parasites & Vectors
Knowles DP, Kappmeyer LS, Stiller D, Hennager SG, Perryman LE. Antibody to a recombinant merozoite protein epitope identifies horses infected with Babesia equi. J Clin Microbiol. 1992;30:3122–6. CAS PubMed PubMed Central Google Scholar Ueti MW, Palmer GH, Kappmeyer LS, Statdfield M, Scoles GA, Knowles DP. Ability of the vector tick…
A look at what didn’t happen this week
FILE – A health worker administers a dose of COVID-19 vaccine during a vaccination clinic in Reading, Pa. On Friday, Nov. 24, 2023, The Associated Press reported on stories circulating online incorrectly claiming Pfizer’s COVID-19 vaccine contains a DNA sequence called Simian Virus 40 that can cause health problems, including…
Our Services Biohazard Cleanup, Crime Scene Cleanup, Unattended Death Cleanup, Suicide Cleanup, Odor Abatement, and more in Pittsburgh, Washington, Beaver, Uniontown, Butler, Waynesburg, Greensburg, Indiana, Kittanning, PA, and Southwest Pennsylvania surrounding areas
At DASH Bio-Recovery, we carry out the needed clean-up work to restore scenes of crime and trauma to a state of normalcy. Available 24/7/365 Since 2005, we have been specializing in clearing out biohazards from residential, commercial, industrial, and federal properties. DASH provides remediation for Suicides, Homicides, Un-attended Deaths (Decomps),…
Whole mitochondrial genome sequencing provides new insights into the phylogeography of loggerhead turtles (Caretta caretta) in the Mediterranean Sea
Andrews S (2010) FastQC: a quality control tool for high throughput sequence data. www.bioinformatics.babraham.ac.uk/projects/fastqc Avise JC (1986) Mitochondrial DNA and the evolutionary genetics of higher animals. Philos Trans R Soc Lond B 312:325–342. doi.org/10.1098/rstb.1986.0011 Article CAS Google Scholar Baker CS, Steel D, Calambokidis J, Falcone E, González-Peral U, Barlow J,…
In silico study about the influence of electroporation parameters on the cellular internalization, spatial uniformity, and cytotoxic effects of chemotherapeutic drugs using the Method of Fundamental Solutions
Batista Napotnik T, Miklavčič D (2018) In vitro electroporation detection methods – an overview. Bioelectrochemistry 120:166–182. doi.org/10.1016/j.bioelechem.2017.12.005 Article CAS PubMed Google Scholar Kotnik T, Rems L, Tarek M, Miklavčič D (2019) Membrane electroporation and electropermeabilization: mechanisms and models. Annu Rev Biophys 48(1):63–91. doi.org/10.1146/annurev-biophys-052118-115451 Article CAS PubMed Google Scholar Rems L,…
Phenotypic drug-susceptibility profiles and genetic analysis based on whole-genome sequencing of Mycobacterium avium complex isolates in Thailand
Abstract Mycobacterium avium complex (MAC) infections are a significant clinical challenge. Determining drug-susceptibility profiles and the genetic basis of drug resistance is crucial for guiding effective treatment strategies. This study aimed to determine the drug-susceptibility profiles of MAC clinical isolates and to investigate the genetic basis conferring drug resistance using…
Molecular epidemiology and characteristics of respiratory syncytial virus among hospitalized children in Guangzhou, China | Virology Journal
Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clin Microbiol Rev. 2000;13(3):371–84. Article CAS PubMed PubMed Central Google Scholar Walker CLF, Rudan I, Liu L, Nair H, Theodoratou E, Bhutta ZA, O’Brien KL, Campbell H, Black RE. Global burden of childhood pneumonia and diarrhoea. Lancet (London, England). 2013;381(9875):1405–16….
Association between mitochondrial DNA levels and depression: a systematic review and meta-analysis | BMC Psychiatry
Tartt AN, Mariani MB, Hen R, Mann JJ, Boldrini M. Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications. Mol Psychiatry. 2022;27(6):2689–99. doi.org/10.1038/s41380-022-01520-y Article CAS PubMed PubMed Central Google Scholar Friedrich MJ. Depression is the leading cause of disability around the World. JAMA. 2017;317(15):1517. doi.org/10.1001/jama.2017.3826 Article PubMed …
Sequencing 101: Tandem repeats – PacBio
In the field of genetics, the concept of tandem repeats has been both scientifically fascinating, experimentally challenging, and motivating for technology development. As DNA sequencing technologies and analysis tools have evolved, scientists are now able to reveal the secrets hidden within these repetitive sequences, shedding light on their significance in…
Elevated stress response marks deeply quiescent reserve cells of gastric chief cells
Generation of inducible H2b-GFP knock-in mice Generation of inducible H2b-GFP knock-in mice was performed by using CRISPR/Cas943. In brief, a mixture containing a sgRosa26-1 crRNA43 (8.7 ng/μl, Fasmac, Japan), a tracrRNA (14.3 ng/μl, Fasmac, Japan), a single strand oligo donor nucleotide (ssODN) composed of 5′ arm, adenovirus splicing acceptor, SV40 pA, TRE3G…
Bioinformatics Hospital Research IT Program Manager – Partner’s Consulting, Inc.
Title: Bioinformatics Hospital Research IT Program Manager Location: Philadelphia, PA (Hybrid remote with 20% onside as needed) Type: Temp-to-Perm Our client is seeking a Bioinformatics Healthcare Research Information Technology (IT) Program Manager who will develop organizational technology solutions and informatics strategies for Clinical Research teams that leverage technology. Description The…
US Department of Agriculture (USDA) Agricultural Research Service (ARS) hiring Biologist (Computational Bioinformatics) in Las Cruces, NM
Summary This position is in the Agricultural Research Service (ARS), Field Organization, Plains Area (PA), Range Management Research Unit located in Las Cruces, NM. In this position, you will be responsible for integrating existing databases and identifying and implementing procedures for analysis of vegetation, climate and soil data in agroecosystems…
Wheat Sequencing: The Pan-Genome and Opportunities for Accelerating Breeding
Abberton M, Batley J, Bentley A, Bryant J, Cai H, Cockram J, Costa de Oliveira A, Cseke LJ, Dempewolf H, De Pace C, Edwards D, Gepts P, Greenland A, Hall AE, Henry R, Hori K, Howe GT, Hughes S, Humphreys M, Lightfoot D, Marshall A, Mayes S, Nguyen HT, Ogbonnaya…
Electroporation Transformation of Barley | SpringerLink
Ahloowalia BS (1987) Plant regeneration from embryo-callus culture in barley. Euphytica 36: 659–665 CrossRef Google Scholar Ahokas H (1989) Transfection of germinating barley seed electrophoretically with exogenous DNA. Theor Appl Genet 77: 469–472 CrossRef CAS Google Scholar Barro F, Cannell ME, Lazzeri PA, Barcelo P (1998) The influence of auxins…
RCSB PDB – 8PBD: RAD51 filament on dsDNA bound by the BRCA2 c-terminus
ATPQuery on ATP Download Ideal Coordinates CCD File  CA [auth C]FA [auth D]IA [auth E]LA [auth F]OA [auth G] CA [auth C],FA [auth D],IA [auth E],LA [auth F],OA [auth G],RA [auth H],UA [auth I],V [auth A],XA [auth J],Z [auth B] Less ADENOSINE-5′-TRIPHOSPHATEC10 H16 N5 O13 P3ZKHQWZAMYRWXGA-KQYNXXCUSA-N CAQuery on CA Download…
Inhibition of providencia vermicola FabD
Introduction Microbial resistance has become a problem in the contemporary medical environment due to the inadequate development of new antibiotics and the asinine prescription of antibiotics in both developed and developing nations. Antimicrobial resistance (AMR), which affects wealthy and developing nations, is a global concern.1 AMR is a problem for…
Century Therapeutics and FUJIFILM Cellular Dynamics Announce Licenses for the Development and Commercialization of iPSC-Derived Cell Therapies in Autoimmune and Inflammatory Diseases
PHILADELPHIA, PA — Century Therapeutics, Inc. (NASDAQ: IPSC) and FUJIFILM Cellular Dynamics, Inc. recently announced a new worldwide license agreement and expansion of existing licenses for the development and commercialization of cell therapies derived from iPSCs for the treatment of autoimmune and inflammatory diseases, including type 1 diabetes, multiple sclerosis,…
Sustained Reductions in Lp(a) Achieved With Novel siRNA Drug
In an early phase multicenter clinical study, large reductions in lipoprotein(a), or Lp(a), were achieved with a well-tolerated small interfering RNA (siRNA) therapeutic, lepodisiran. The reductions in serum Lp(a) in patients receiving lepodisiran were dose dependent but adverse events were not, said Steven E. Nissen, MD, professor of medicine at…
The mystery of the ‘black box’ at the MacBook event. What is that object?
The mystery of the ‘black box’ at the MacBook event. What is that object? On October 30th, during the latter part of Apple’s new MacBook Pro unveiling event, a black machine box connected to the MacBook was briefly captured on camera. The presenter at the event was discussing the speed…
Personalized Treatment Sequencing Is a New Way of Thinking in Breast Cancer
Sara M. Tolaney, MD, MPH, chief of the Division of Breast Oncology and associate director of the Susan F. Smith Center for Women’s Cancers, senior physician at Dana-Farber Cancer Institute, and associate professor of medicine at Harvard Medical School, all in Boston, Massachusett In a rapidly evolving field, new strides…
Genomics of soil depth niche partitioning in the Thaumarchaeota family Gagatemarchaeaceae
Sheridan, P. O. et al. Gene duplication drives genome expansion in a major lineage of Thaumarchaeota. Nat. Commun. 11, 1–12 (2020). Article Google Scholar Sheridan, P. O., Meng, Y., Williams, T. A. & Gubry-Rangin, C. Recovery of Lutacidiplasmatales archaeal order genomes suggests convergent evolution in Thermoplasmatota. Nat. Commun. 13, 1–13…
Madrigal Pharmaceuticals Presents New Data from the Phase 3
Data to be featured in an oral presentation at the American Association for the Study of Liver Diseases (AASLD) Liver Meeting® Analyses from comprehensive set of noninvasive tests used in MAESTRO-NASH provide new insights on strategies to identify patients and measure response to resmetirom A significant majority (>70%) of patients…
Your weekly fix of the latest biotech news: November 10, 2023
You are reading Labiotech’s weekly roundup of the latest biotech news. Korro Bio and Frequency Therapeutics close merger Last Friday, Korro Bio announced the completion of the previously announced business combination between Frequency Therapeutics, Inc. and the entity formerly known as Korro Bio. The combined company will now operate under…
DNA microarray technique for infectious disease diagnostics.
Introduction Infectious diseases are illnesses caused by pathogenic microbes such as bacteria, viruses, parasites, or fungus, which can be transmitted directly or indirectly from one person to another.1 Throughout human history, infectious illnesses have been a major cause of morbidity and mortality. One-third of all death worldwide is caused by…
Shallow whole genome sequencing approach to detect Homologous Recombination Deficiency in the PAOLA-1/ENGOT-OV25 phase-III trial
Polak P, Kim J, Braunstein LZ, Karlic R, Haradhavala NJ, Tiao G, et al. A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer. Nat Genet. 2017;49:1476–86. Article CAS PubMed PubMed Central Google Scholar Birkbak NJ, Wang ZC, Kim JY, Eklund AC, Li Q, Tian R, et…
Divergent mechanisms of reduced growth performance in Betula ermanii saplings from high-altitude and low-latitude range edges
Aizawa M, Yoshimaru H, Saito H, Katsuki T, Kawahara T, Kitamura K et al. (2009) Range‐wide genetic structure in a north‐east Asian spruce (Picea jezoensis) determined using nuclear microsatellite markers. J Biogeogr 36(5):996–1007 Article Google Scholar Alexander DH, Novembre J, Lange K (2009) Fast model-based estimation of ancestry in unrelated…
William meets scientists fighting wildlife poachers and traffickers
The international black market in flora and fauna is estimated to be worth £16.35 billion a year and is said to be the world’s fourth most lucrative illegal industry after human trafficking, drugs, and arms. William, 41, went to Singapore’s Centre for Wildlife Forensics to see how the country is…
Landscape genomics reveals adaptive genetic differentiation driven by multiple environmental variables in naked barley on the Qinghai-Tibetan Plateau
Abebe TD, Naz AA, Léon J (2015) Landscape genomics reveal signatures of local adaptation in barley (Hordeum vulgare L.). Front Plant Sci 6:813 Article PubMed PubMed Central Google Scholar Alexander DH, Novembre J, Lange K (2009) Fast model-based estimation of ancestry in unrelated individuals. Genome Res 19:1655–1664 Article CAS PubMed …
LAMP assay coupled with a CRISPR/Cas12a system for the rapid and ultrasensitive detection of porcine circovirus-like virus in the field
Shulman LM, Davidson I. Viruses with circular single-stranded DNA genomes are everywhere! Annual Rev Virolog. 2017;4(1):159–80. doi.org/10.1146/annurev-virology-101416-041953. Article CAS Google Scholar Yang K, Zhang M, Liu Q, Cao Y, Zhang W, Liang Y, Song X, Ji K, Shao Y, Qi K, Tu J. Epidemiology and evolution of emerging porcine circovirus-like…
VistaGen Therapeutics (VTGN) to Present Positive Fasedienol Phase 3 Data and Positive PH80 Phase 2A Data at Upcoming Scientific Conferences
Vistagen (Nasdaq: VTGN), a late clinical-stage biopharmaceutical company aiming to transform the treatment landscape for individuals living with anxiety, depression, and other central nervous system (CNS) disorders, today announced the Company will present at two upcoming scientific conferences in November. “Vistagen’s presentations highlight the significant progress we have made to…
AI Architect – Computing Services Job Opening in Pittsburgh, PA at Carnegie Mellon University
Job Posting for AI Architect – Computing Services at Carnegie Mellon University Carnegie Mellon has been a leader in Artificial Intelligence since Herbert Simon and Allen Newell invented the field in the 1950s. Would you like to join us as the AI Architect? Say “Yes” and play a…
William admits green campaigning ‘uphill battle’ as he meets Earthshot finalists
The Prince of Wales has admitted that green campaigning is “an uphill battle” while wishing Earthshot Prize finalists good luck ahead of Tuesday’s awards ceremony in Singapore. William, together with Hannah Jones, chief executive of the Earthshot Prize, met all 15 finalists shortlisted for the awards on Tuesday morning at…
Biologist (Computational Bioinformatics) at U.S. Department of Agriculture 758994600
This position is in the Agricultural Research Service (ARS), Field Organization, Plains Area (PA), Range Management Research Unit. The selectee is not required to report to a government office, however, the option to work in one of the Agency offices may be available. In this position, you will provide direct…
Leveraging Bioinformatic Algorithms to Improve the Genomic and Metagenomic Analyses of Bacterial Pathogens
Leveraging Bioinformatic Algorithms to Improve the Genomic and Metagenomic Analyses of Bacterial Pathogens Contact: Zhao (Jack) Chen, MS, PhD zhchen29@umd.edu Overview Advances in next-generation sequencing have revolutionized genomics and metagenomics of bacterial pathogens by increasing throughput exponentially over first-generation Sanger sequencing. Short reads with a low error rate of…
Vera Therapeutics Presents Positive Data from Phase 2b ORIGIN Study Showing Resolution of Hematuria in Majority of Patients at the American Society of Nephrology Kidney Week 2023
Vera Therapeutics Analysis of week 36 data from Phase 2b ORIGIN study shows atacicept 150 mg substantially reduces serum Gd-IgA1 and resolves hematuria in the majority of patients. Additional poster presentations provide further safety analysis of Phase 2b and details of pivotal Phase 3 clinical trial design, which is currently…
R & RStudio Drop-In Hour (On Campus)
Users of R and RStudio are invited to bring their questions to this weekly in-person office hour. Tutoring-style assistance is offered. If we don’t know the answer, we’ll help you look for it! Students, faculty, and staff are all welcome. Example topics we have assisted participants with: base R (working…
Computational Biologist – Zachary Piper Solutions, LLC
Piper Companies is seeking a Computational Biologist to work for an innovative and growing oncology cell therapy company in Philadelphia, PA. Responsibilities for the Computational Biologist • Work to implement NGS and other high-throughput data analysis, and work to derive insights from application to products • Support the design of…
Quantification of rare somatic single nucleotide variants by droplet digital PCR using SuperSelective primers
Primary samples and nucleic acid extraction A cohort of 48 patients diagnosed with advanced adenoma (AAD), defined by size > 20 mm, or colorectal carcinoma (CRC) were collected between 2013 and 2016. The study was approved by the institutional ethics committee of Hospital General Universitario de Alicante (Ref. CEICPI2013/01), and written informed consent…
KEGG T01892: HMPREF4655_20621
Entry HMPREF4655_20621 CDS T01892 Symbol pssA Name (GenBank) CDP-diacylglycerol-serine O-phosphatidyltransferase KO K17103 CDP-diacylglycerol—serine O-phosphatidyltransferase [EC:2.7.8.8] Organism hpo Helicobacter pylori 35A Pathway hpo00260 Glycine, serine and threonine metabolism hpo00564 Glycerophospholipid metabolism hpo01100 Metabolic pathways hpo01110 Biosynthesis of secondary metabolites Module hpo_M00093 Phosphatidylethanolamine (PE) biosynthesis, PA => PS => PE Brite KEGG Orthology (KO) [BR:hpo00001] 09100…
Comparison of DNA Extraction Methods for the Detection of Canned Tuna Species with DNA Mini-Barcoding
Tuna is susceptible to species mislabeling due to its high demand, quick rate of production, and wide range of price points. DNA barcoding, a sequencing-based technique, allows for the detection of species mislabeling by targeting a standardized region of DNA. A mitochondrial control region (CR) DNA barcode has been found…
papain family cysteine protease containing protein, maker-scaffold1702_size30647-snap-gene-0.14 (gene) Tigriopus kingsejongensis
Associated RNAi Experiments Homology BLAST of papain family cysteine protease containing protein vs. L. salmonis genes Match: EMLSAG00000006045 (supercontig:LSalAtl2s:LSalAtl2s327:400616:404607:-1 gene:EMLSAG00000006045 transcript:EMLSAT00000006045 description:”augustus_masked-LSalAtl2s327-processed-gene-4.0″) HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0Identity = 283/525 (53.90%), Postives = 368/525 (70.10%), Query Frame = 0 Query: 49 GHVARPLGKSPPNFVRDPPPRTTPPAQWLWNNVNETNFLTVSRNQHLPTYCGSCWAHAATSSLSDRIKIARQGAWPDINLAPQVLISCGPGDGCHGGEAGDANAYMHAQGITDETCSIYRARGQDNGLPCSKLEICSTCE—SKCYQPQHFFTYRVDEFHDVEGESNGEQEANMMAEIHHRGPISCGIAVTQALV-NYTGGLFHDKTGAQEIDHDISVVGYGVDEGTQEKYWLIRNSWGTYWGEQGFFRLIRGVNNLGIESGTCSWATPADTWSDAARE—RAAILSNEITLQKP——LWKQLWTVVADFVDNTRDTDLFRRLKLMQKGCKKLSSPRVPVVNIRPRPQDYVSTADLPEALDWRSVNGTNFLSWSVNQHLPVYCGSCWAQAGLSSLADRFTIADRKRFANLALSVQYILNCQAGGSCHGGDAFPLYAFIQKQGVPDVTCQPYEALDEGPLTDCSKPSKLVCKDCTWPPPEPGQEGNCWAKEKFHRYYVDEYNGVEGADNMKKEILERGPVT 560 GH+ R G+…
Carisma to Present First Results From in vivo CAR-M Collaboration with Moderna at SITC 2023
PHILADELPHIA, PA — Carisma Therapeutics Inc. (Nasdaq: CARM) announced that new pre-clinical data leveraging an mRNA platform to develop in-vivo chimeric antigen receptor macrophage (“CAR-M”) will be presented as a late-breaking abstract (#LBA1514) at the upcoming Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting held from Wednesday, November 1, to Sunday, November 5, 2023, in San Diego,…
Phase separation in cGAS-STING signaling
Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 2013; 339(6121): 786–791 Article CAS PubMed Google Scholar Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ. Cyclic GMP-AMP…
Genomics Research Incubator expands assay and training options for scientists
UNIVERSITY PARK, Pa. — Many Penn State researchers are familiar with the Genomics Core Facility in the Huck Institutes of the Life Sciences, where hundreds of researchers work with tens of thousands of samples every year. Since 2022, a complementary endeavor has made another sequencing option available to University scientists….
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Carisma to Present First Results From in vivo CAR-M Collaboration with Moderna at SITC 2023 | DNA RNA and Cells
Carisma to Present First Results From in vivo CAR-M Collaboration with Moderna at SITC 2023 Details Category: DNA RNA and Cells Published on Thursday, 26 October 2023 11:41 Hits: 269 -Late-breaking abstract to be presented on November 3rd at 11:30 am PT highlighting pre-clinical data with Moderna -Two additional…
Jazz Pharmaceuticals Senior Director, Head of Bioinformatics in Center City, PA | 879296423
If you are a Jazz employee please apply via the Internal Career site Jazz Pharmaceuticals plc (NASDAQ: JAZZ) is a global biopharmaceutical company whose purpose is to innovate to transform the lives of patients and their families. We are dedicated to developing life-changing medicines for people with serious diseases –…
Dheeraj Mohandas Pai’s Resume
Dheeraj Mohandas Pai’s Resume Email: dheerajpai@cmu.edu | Phone: +1 (412)-909-7045 Address: Carnegie Mellon University, 5000 Forbes Avenue, Pittsburgh Website: dheerajpai.github.io Education Carnegie Mellon University (Aug 2022 – Dec 2023)Masters, Artificial Intelligence | Pittsburgh, PA Indian Institute of Technology Madras (Aug 2019)Bachelors, Electrical and Computer Engineering | Chennai, India Experience Qualcomm…
Diverse electron carriers drive syntrophic interactions in an enriched anaerobic acetate-oxidizing consortium
Nobu MK, Narihiro T, Mei R, Kamagata Y, Lee PKH, Lee P-H, et al. Catabolism and interactions of uncultured organisms shaped by eco-thermodynamics in methanogenic bioprocesses. Microbiome. 2020;8:111. Article CAS PubMed PubMed Central Google Scholar Conrad R. Contribution of hydrogen to methane production and control of hydrogen concentrations in methanogenic…
Receive SMS Online From KAGGLE For Free For SMS Verification
Receive Free SMS From KAGGLE Receive SMS Online for KAGGLE. You don’t have to register an account or anything like that. Just use one of the phone numbers below and use them for KAGGLE phone / SMS verifications. Kaggle is a data science platform that enables users to find and…
Final Multivariate Analysis from the Phase 3 MAGNITUDE Study Shows Trend Toward Improvement in Overall Survival in Patients with mCRPC with BRCA Alterations Treated with Niraparib and Abiraterone Acetate Plus Prednisone
Niraparib and abiraterone acetate plus prednisone combination therapy also showed clinically relevant improvement versus standard of care in time to symptomatic progression and time to cytotoxic chemotherapy MADRID, Oct. 22, 2023 /PRNewswire/ — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced results from the final analysis (FA) of…