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siRNA, Anti-Human LRRC41, LNA (SIRGT34852WQ-LNA)
For research use only. Not intended for any clinical use. Name * Phone * Email * Subject Project Description …
Prashant Mehta: My thoughts on developments in DLBCL management
Prashant Mehta, Senior Consultant and Assistant Professor in the Department of Medical Oncology/Hematology-oncology and Bone marrow transplantation at the Amrita Hospital, Faridabad, shared a thread on X/Twitter: “My thoughts on developments in Diffuse Large B Cell Lymphoma (DLBCL) management: Despite several combination studies with R-CHOP, in the last 20 years…
Catlett-Votca Family History
Catlett-Votca Family History Sorted By Name.com Catlett-Votca Family History Page Public information, by definition, is not private. In December 2023, 1,657,853 entries were added from Maryland death indices, part of the MOTHERLODE released by the Maryland State Archives. Special thanks to Reclaim The Records for acquiring this information. Please consider…
Finally, the Coyotes are headed in the right direction
BUFFALO – Bill Armstrong settled into a chair in KeyBank Center’s empty and dark press box last week, his iPhone and a large Starbucks cup resting on the ledge in front of him. Hours from hosting a Coyotes-Sabres game, the arena was silent save for the sounds of skates, sticks,…
Food Authenticity Market worth $12.23 billion by 2030, growing
Food Authenticity Market | 360iResearch The “Food Authenticity Market by Type (DNA Sequencing/Barcoding, Immunoassay-Based/Enzyme-Linked Immunosorbent Assay (ELISA), Isotope Methods), Category (Adulteration Tests, Allergen Testing, False Labelling), Application – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. The Global Food Authenticity Market to grow from USD 7.27 billion in…
A STING Operation in neuroendocrine neoplasms | NANETS2023 | NANETS 2023
1Huntsman Cancer Institute, University of Utah, Salt Lake City, UT; 2University of Minnesota, Minneapolis, MN; 3Caris Life Sciences, Phoenix, AZ; 4The Ohio State University, Columbus, OH; 5Fox Chase Cancer Center, Philadelphia, PA; 6Sylvester Cancer Center, University of Miami, Miami, FL; 7Brown University, Providence, RI Background: Significant advances have been made…
Robin McCarley elected fellow of the National Academy of Inventors | Virginia Tech News
Robin McCarley has been named a fellow of the National Academy of Inventors (NAI). The executive director of the Fralin Life Sciences Institute and a professor in the Department of Chemistry, McCarley joins an elite group of six current Virginia Tech NAI fellows, including most recently Roe-Hoan Yoon in the Department…
Whole mitochondrial and chloroplast genome sequencing of Tunisian date palm cultivars: diversity and evolutionary relationships | BMC Genomics
Johnson DV, Al-Khayri JM, Jain SM. Introduction: Date Production Status and Prospects in Africa and the Americas. In: Al-Khayri J, Jain S, Johnson D, editors. Date Palm Genetic Resources and Utilization: Volume 1: Africa and the Americas. Springer Netherlands, Dordrecht; 2015. p. 1–18. doi.org/10.1007/978-94-017-9694-1_1 Gros-Balthazard M, Hazzouri KM, Flowers JM. Genomic…
City of Hope Scientists Present Promising New Research at American Society of Hematology Annual Meeting
This section is Partnership Content supplied The content in this section is supplied by Business Wire for the purposes of distributing press releases on behalf of its clients. Postmedia has not reviewed the content. by Business Wire Breadcrumb Trail Links PMN Press Releases Business Wire News Releases Author of the…
Bioinformatics Analyst – Charlottesville, Virginia, United States
Who would you like to share this job with? 11101fb9 Categories 2c89bb9c Categories 3c530996 Academic Advising / SupportAdministrationAdministrative / ClericalAdministrative ServicesAdvancementAgriculture / Life ScienceAgriculture and Animal HealthAlumni RelationsApplied Sciences and Natural ResourcesArchitecture / Construction / PlanningArchitecture / EngineeringAudit and FinanceBusiness / Accounting / FinanceCommunications / Public Relations / MarketingData…
Technical Details and Software Platform
AMD has released the Ryzen 8040 series of laptop processors, an update to the existing Ryzen 7040 series. These processors are designed with enhanced compatibility for a newly introduced software platform, which aims to streamline the development of AI applications by leveraging the integrated neural processing unit (npu). The Ryzen…
Hawk Point with Zen 4 and Ryzen AI
Although CES 2024 is happening next month in Las Vegas, AMD has lifted the lid on their latest Zen 4 mobile processors, the Ryzen Mobile 8040 series. Codenamed Hawk Point, the Ryzen Mobile 8040HS series is set to be the successor to this year’s ‘Phoenix’ mobile chips. Two new families…
Broadway Curve project on Interstate 10 enters Phase 3
PHOENIX — Phase three is now underway for the Interstate 10 Broadway Curve Improvement Project after two-and-a-half years since the project began. There are a number of tasks the project will incorporate. Included among them by the Arizona Department of Transportation are: Also included are the widening of bridges and…
siRNA, Anti-Human ALAS1, 2′-F (SIRGT02138WQ-2F)
For research use only. Not intended for any clinical use. Name * Phone * Email * Subject Project Description …
Serial Next Generation Sequencing and the Role of PARP Inhibitor Therapy in 2024
(UroToday.com) The 2023 Society of Urologic Oncology (SUO) annual meeting held in Washington, D.C. between November 28th and December 1st, 2023, was host to a prostate cancer course. Dr. Alan Bryce provided an overview of the use and application of serial next generation sequencing (NGS) in the castrate-resistant prostate cancer disease…
Draft genome sequencing of halotolerant bacterium Salinicola sp. DM10 unravels plant growth-promoting potentials
Afridi MS, Amna S et al (2019) Induction of tolerance to salinity in wheat genotypes by plant growth promoting endophytes: Involvement of ACC deaminase and antioxidant enzymes. Plnat Physiol Biochem 139:569–577. doi.org/10.1016/j.plaphy.2019.03.041 Article CAS Google Scholar Ali S, Charles TC, Glick BR (2014) Amelioration of high salinity stress damage by…
Arizona Investigators Identify Teen Girl Found Dead in 1992
After more than three decades as a Jane Doe, an unidentified teen girl in an Apache Junction, Arizona, cold case now has a name, the city’s police department announced Thursday. She was identified as 15-year-old Melody Harrison, who was reported missing from Phoenix in June 1992. Officials credited the “persistent”…
Iron derived from NCOA4-mediated ferritinophagy causes cellular senescence via the cGAS-STING pathway
Materials and reagents Tert-butyl hydroperoxide (TBH) were purchased from Sigma-Aldrich (St. Louis, USA). Ferric ammonium citrate (FAC) and D-galactose (D-gal) was obtained from Selleck (Shanghai, China) and Aladdin (Shanghai, China), respectively. Deferoxamine (DFO), Mito-TEMPO (Mito-T), 3-Methyladenine (3-MA), Chloroquine (CQ), Bafilomycin A1 (Baf-A1), and H-151 were purchased from MedChemExpress (NJ, USA)….
Plant Genomics Market worth $18.98 billion by 2030, growing at
Plant Genomics Market | 360iResearch The “Plant Genomics Market by Objective (DNA Extraction & Purification, DNA/RNA Sequencing, Gene Expression Profiling), Type (Genetic Engineering, Molecular Engineering), Trait, Crops – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. The Global Plant Genomics Market to grow from USD 9.37 billion in…
Veterinary Molecular Diagnostic Market worth $1,071.85
Veterinary Molecular Diagnostic Market | 360iResearch The “Veterinary Molecular Diagnostic Market by Product (Instruments & Software, Kits & Reagent, Services), Technology (DNA Sequencing, Microarrays, Polymerase Chain Reaction), Animal Type, Disease Indication, End User – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. The Global Veterinary Molecular Diagnostic Market…
Mayo Clinic hiring Intern – Bioinformatics (PHD) (NE) – Research in Rochester, MN
Why Mayo ClinicMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to…
Three decades later: Jane Doe identified in Apache Junction cold case breakthrough, police say
More than 30 years of mystery have shrouded the identity of the Apache Junction Jane Doe case. The unidentified female has been identified as 15-year-old Melody Harrison, who was reported missing from Phoenix in June 1992. Her identification was possible through the persistent efforts of Apache Junction Police Investigator Stephanie…
Cloud Price Quarterly: India yields bargains; public cloud benchmarks tick up
Thanks in part to government initiatives, public cloud prices for general, compute and memory virtual machines in India are now the lowest among the 10 regions tracked by 451 Research’s Cloud Price Index, while leased datacenter capacity in this market is expected to more than triple over the next five…
Chorea severity remains reduced after 1 year on Ingrezza: Trial
Nearly a year of treatment with Neurocrine Biosciences’ Ingrezza (valbenazine) leads to sustained reductions in uncontrolled movements known as chorea in adults with Huntington’s disease, according to interim data from a Phase 3 trial called KINECT-HD2. “The 50-week data from the ongoing KINECT-HD2 study provide insight on the potential long-term…
Is Breast Implant Linked to Lymphoma Risk
Breast implants are medical devices used to increase the size, shape, or fullness of a woman’s breasts. Lymphoma is a type of cancer that begins in the lymphatic system. While there have been some reports of a potential association between breast implants and lymphoma, research has not established a definitive…
Imugene share price jumps 34% on ‘major milestone’: What is it?
Image source: Getty Images The Imugene Limited (ASX: IMU) share price is continuing its incredible run and charging higher again on Friday. In early trade, the clinical stage immuno-oncology company’s shares were up a further 34% to 15 cents. Its shares have since pulled back but remain up 14% to…
Imugene doses first patient in US trial of Azer-cel allogeneic CAR T therapy
Sydney-headquartered clinical stage immuno-oncology company Imugene (ASX: IMU) has achieved an early milestone with the dosing in the US of the first patient using its recently acquired Azer-cel blood cell therapy. Earlier this year, Imugene reached an agreement with US-based Precision Biosciences to acquire the global exclusive license to the…
Holy grail cancer treatment one step closer for Imugene
Imugene has continued to set the ASX boards alight after revealing it had delivered the first dose of its azer-cel therapy to a patient suffering from “difficult-to-treat” diffuse large B-cell lymphoma (DLBCL) in the United States. The company’s stock has risen nearly 285 per cent in less than three weeks…
Majority of Patients With Generalized Myasthenia Gravis Fail to Meet Clinical Trial Criteria
In a new retrospective study presented at the American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) meeting, held November 1-4, in Phoenix, Arizona, a majority of patients with anti-acetylcholine receptor (AChR) antibody-positive generalized myasthenia gravis (gMG) treated in routine care did not meet criteria for a potential phase 3 clinical trial….
Sub-Analysis of CHAMPION MG Study Reveals No Differences in Ravulizumab Treatment Based on Prior Immunoglobulin Use
In a new post hoc sub-analysis of the phase 3 CHAMPION MG study (NCT03920293), findings showed no statistically significantly differences in outcomes among patients with anti-acetylcholine receptor antibody-positive (AChR Ab+) generalized myasthenia gravis (gMG) who on intravenous immunoglobulin (IVIg) after starting treatment with ravulizumab (Ultomiris; AstraZeneca), an FDA-approved agent.1 Among…
Long-term Trikafta maintains efficacy in CF children
Long-term Trikafta treatment led to sustained improvements in CFTR function and reduced lung symptoms in children, ages 6-11, with cystic fibrosis (CF), according to almost three years of interim data from an open-label extension (OLE) study. There were no signs of lung function decline during the 3.5-year treatment period that…
Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates
Gerken, K. N. et al. Paving the way for human vaccination against Rift Valley fever virus: a systematic literature review of RVFV epidemiology from 1999 to 2021. PLoS Negl. Trop. Dis. 16, e0009852 (2022). Article CAS PubMed PubMed Central Google Scholar Pepin, M., Bouloy, M., Bird, B. H., Kemp, A….
Zilucoplan Shows Reduction in MG Worsening in Phase 3 RAISE Study for Generalized Myasthenia Gravis
Angela Genge, MD, FRCPC, eMBA In a new post hoc analysis of the phase 3 RAISE study (NCT04115293) assessing zilucoplan (Zilbrysq; UCB Pharma), an FDA-approved complement C5 inhibitor, findings showed a significantly lower proportion of patients who experienced myasthenia gravis (MG) worsening when treated with the therapy than placebo. Additionally,…
DNA identifies body found 34 years ago in WA as missing man
Clifford Wayne Bippes’ body was found July 2, 1989, in a landfill in Spokane, Washington. DNA testing identified his remains 34 years later. Spokane County Medical Examiner’s Office A worker uncovered human remains in a Washington landfill 34 years ago, officials said. Those remains have just been identified as then-45-year-old…
Vutrisiran Shows Benefit Across Baseline Severities in Phase 3 HELIOS-A Study
In a new post-hoc analysis of the phase 3 HELIOS-A study (NCT03759379) assessing vutrisiran (Amvuttra; Alnylam), an FDA-approved RNA interference therapeutic, the therapy demonstrated benefit in key measures, compared with external placebo, across all baseline polyneuropathy severities among patients with hereditary transthyretin-mediated (hATTR) amyloidosis. These results suggest patients who initiate…
Understanding the ADAPT-SC Results of Subcutaneous Efgartigimod: Tuan Vu, MD
WATCH TIME: 3 minutes “There was no new signal in terms of safety events. I think it’s [subcutaneous efgartigimod] a good option for patients who want to have the flexibility of having a subcutaneous injection at home or elsewhere.” Over the years, the treatment options for patients with generalized myasthenia…
Open-Label PROPEL Study Results Highlight Longterm Impact of Cipaglucosidase Alfa and Miglustat in Late-Onset Pompe Disease
New data from the phase 3 PROPEL study (NCT04138277) showed that treatment with cipaglucosidase alfa (Pombiliti)/miglustat (Opfolda), a recently approved 2-component agent, was effective in patients with late-onset pompe disease (LOPD) for up to 104 weeks. These data, presented at the 2023 American Association of Neuromuscular and Electrodiagnostic Medicine (AANEM)…
Metagenomic Sequencing Market worth $4.89 billion by 2030,
Metagenomic Sequencing Market | 360iResearch The “Metagenomic Sequencing Market by Product & Service (Analysis & Data Interpretation Solutions, Instruments, Reagents & Consumables), Workflow (Data Processing & Analysis, Sample Processing & Library Preparation, Sequencing), Technology, Application – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. Request Sample Copy of…
Human remains ID’d 50 years after found in CA bay, cops say
Arminda Grangeia Rodrigues da Silva Ribeiro’s remains were found by fishermen June 13, 1973, in the San Diego Bay in California. DNA testing identified her remains 50 years later. Fishermen found a woman’s dismembered remains in an orange suitcase in a California bay 50 years ago, police said. DNA testing…
City of Hope part of successful international
image: “This is the first Phase 3 clinical trial to show a benefit over standard of care in patients with the KRAS G12C mutation whose cancer progressed after receiving standard chemotherapy. The efficacy results from our study are promising in this population with unmet needs and should set a new…
Caris Life Sciences and Moderna Announce Multi-Year Strategic Partnership to Advance mRNA-Based Oncology Therapeutics
Partnership enables Moderna to leverage Caris’ vast library of de-identified, multi-modal data and analytics capabilities to accelerate precision medicine and the delivery of novel medicines to patients IRVING, Texas, Oct. 24, 2023 /PRNewswire/ — Caris Life Sciences®(Caris), the leading next-generation AI TechBio company and precision medicine pioneer that is actively…
TUDCA given ALS patients at higher dose seen to extend survival
People with amyotrophic lateral sclerosis (ALS) who are treated daily with 1,000 mg or higher doses of tauroursodeoxycholic acid (TUDCA) tend to live longer than those given standard care alone, according to an analysis of registry data. “In our ‘real-world’ study, patients who received TUDCA at the higher dose survived…
Oncology NGS Market worth $1,200.39 million by 2030, growing at
Oncology NGS Market | 360iResearch The “Oncology NGS Market by Technology (Amplicon-based, Hybridization-based, Targeted & Gene Panel Sequencing), Product & Service (Platforms & Related Products, Services), Application – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. Request Sample Copy of this Report @ www.360iresearch.com/library/intelligence/oncology-ngs?utm_source=openpr&utm_medium=referral&utm_campaign=sample Market Segmentation & Coverage:…
UAE and US (built in SAM profile) based PV performance & Economic Analysis Issue – SAM Forum – System Advisor Model
Hello, Thank you for sending the files. Attached is a file I created from your files to make it easier to compare. You can use the File -> Inputs Browser command to compare the inputs between the two cases. The system in Phoenix produces about 12% more electricity in year…
Mayo Clinic hiring Bioinformatician in Jacksonville, FL
Why Mayo ClinicMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to…
Bioinformatics Phoenix
News:Bioinformatics Phoenix 0 Hi Everyone, I have recently been working to revive a suite of online bioinformatics software developed circa 2000 to 2012. The front page is here 174.83.15.115:8090 If I could muster enough interest, I intend to make this suite available long term using big-data cloud services. Any comments…
SAP Financial Results Q3 2023
SAP Financial Results Q3 2023 SAP financial results for Q3 2023 have been announced, showing a strong performance for the quarter and bright prospects for the future, so this week IgniteSAP will provide a summary of the report and discuss what these numbers mean for SAP and the wider ecosystem…
SAP Announces Q3 2023 Results
in € millions, unless otherwise stated; based on SAP group results from continuing operations Cloud revenue up 16% and up 23% at constant currencies Current cloud backlog of €12.3 billion up 19% and up 25% at constant currencies IFRS cloud gross profit up 21%, non-IFRS cloud gross profit up 21%…
UCB Reinforces Commitment to Advancing Care in Hidradenitis Suppurativa with Six Abstracts at SHSA 2023
ATLANTA, Oct. 13, 2023 /PRNewswire/ — UCB, a global biopharmaceutical company, today announced that it will present six abstracts in hidradenitis suppurativa (HS) at the 8th Annual Symposium on Hidradenitis Suppurativa Advances (SHSA), October 13–15 in Phoenix, Arizona. Data and analyses in HS will be presented across two oral presentations and…
Mutation Detection Kits In Genome Editing Market worth
Mutation Detection Kits In Genome Editing Market | 360iResearch The “Mutation Detection Kits In Genome Editing Market by Genome (CRISPR/Cas9, Meganucleases, TALENs/MegaTALs), End-Use (Academic Research Institutes, Biotechnology & Pharmaceutical Companies, Contract Research Organizations) – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. Request Sample Copy of this Report…
NGS Sample Preparation Market worth $6.80 billion by 2030,
NGS Sample Preparation Market | 360iResearch The “NGS Sample Preparation Market by Product (Reagents & Consumables, Workstations), Workflow (DNA, Library Preparation, Quality Control), Technology, Application, End-User – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. Request Sample Copy of this Report @ www.360iresearch.com/library/intelligence/ngs-sample-preparation?utm_source=openpr&utm_medium=referral&utm_campaign=sample Market Segmentation & Coverage: This…
Progressive Treatment Strategies for DLBCL Directed by NCCN Guidelines
Leo Gordon, MD: First-line treatment in diffuse large B-cell [lymphoma]: First of all, chemotherapy is potentially curative in the majority of patients with DLBCL. There have been a number of decades-long comparisons of different chemotherapy regimens. I remember we looked at a combination of, before Rituxan [rituximab], CHOP [cyclophosphamide, doxorubicin,…
Early-melting snowpatch plant communities are transitioning into novel states
Körner, C. Alpine Plant Life (Springer, 1999). Book Google Scholar Rixen, C. et al. Intraspecific trait variation in alpine plants relates to their elevational distribution. J. Ecol. 110, 860–875 (2022). Article Google Scholar Wipf, S., Stoeckli, V. & Bebi, P. Winter climate change in alpine tundra: plant responses to changes…
Making Static & Interactive Maps With ggvis
In R Programming Language data visualization, making static and interactive maps is a common activity. Although the R package ggvis allows for interactive data visualizations, map visualizations are not one of its natural capabilities. For static maps and interactive maps, respectively, we commonly utilize tools like ggplot2 and leaflet. In…
Bioinformatics Market worth $88.84 billion by 2030
Bioinformatics Market | 360iResearch The “Bioinformatics Market by Product (Bioinformatics Platform, Bioinformatics Services, Knowledge Management Tools), Application (Chemoinformatics, Genomics, Metabolomics), End-User – Cumulative Impact of COVID-19, Russia Ukraine Conflict, and High Inflation – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. Request Sample Copy of this Report @…
Bioinformatics Services Market worth $109.23 billion by 2030 |
Bioinformatics Services Market | 360iResearch The “Bioinformatics Services Market by Specialty (Animal Biotechnology, Environmental Biotechnology, Forensic Biotechnology), Type (Data Analysis, Database & Management Services, Differential Gene Expression Analysis), Application, End-User – Cumulative Impact of COVID-19, Russia Ukraine Conflict, and High Inflation – Global Forecast 2023-2030” report has been added to…
DNA Sequencing Market worth $212.38 billion by 2030
DNA Sequencing Market | 360iResearch The “DNA Sequencing Market by Product & Services (Consumables, Instruments, Services), Technology (Next-Generation Sequencing, Sanger Sequencing, Third Generation DNA Sequencing), Workflow, Application – Cumulative Impact of COVID-19, Russia Ukraine Conflict, and High Inflation – Global Forecast 2023-2030” report has been added to 360iResearch.com‘s offering. Request…
Purdue Entomology to host second Cold Case Symposium
WEST LAFAYETTE, Ind. – The Purdue College of Agriculture’s Department of Entomology will host the second Cold Case Symposium Oct. 12 in the Purdue Memorial Union. Last year’s symposium was held in Phoenix, Arizona, in partnership with Arizona State University. Partnering with Project: Cold Case, a nonprofit organization dedicated to…
DNA identifies suspect 45 years after teen found dead: cops
Krisann Baxter, 16, was found dead on Oct. 4, 1978, in Spokane County, Washington, deputies said. DNA testing identified a suspect accused in her killing 45 years later. Spokane County Sheriff’s Office A 16-year-old girl’s body was found next to power lines in Washington 45 years ago, deputies said. DNA…
Can We Talk? Artificial Intelligence in the World of Cancer Care
Katie Coleman has utilized online support groups and developed a following via TikTok, X (formerly Twitter), Instagram, YouTube and her “Oncology Unscripted” podcast since receiving her diagnosis of stage 4 kidney cancer. She is now a software engineer for the Rare Cancer Research Foundation. Photo credit: Zach Brigham Software engineer…
Research Scientist in Bioinformatics and Computational Genomics
Who would you like to share this job with? f174ddf1 Categories 7e40f805 Categories 00b0ae88 Academic Advising / SupportAdministrationAdministrative / ClericalAdministrative ServicesAdvancementAgriculture / Life ScienceAgriculture and Animal HealthAlumni RelationsApplied Sciences and Natural ResourcesArchitecture / Construction / PlanningArchitecture / EngineeringAudit and FinanceBusiness / Accounting / FinanceCommunications / Public Relations / MarketingData…
Tech Unemployment Rises to 2.1 Percent
Tech unemployment bumped upward to 2.1 percent in August, according to the latest data from CompTIA. That’s a small-but-notable increase from July, when the unemployment rate stood at 1.8 percent, although it’s still low by historical standards—and beneath the national unemployment rate of 3.8 percent. “The usual caveats of monthly…
RLY-4008 Shows Initial Activity With a Manageable Safety Profile in Cholangiocarcinoma
The first highly selective FGFR2 inhibitor RLY-4008 has displayed preliminary efficacy in patients with cholangiocarcinoma and has the potential to establish another agent in the treatment paradigm, according to Mitesh J. Borad, MD. Borad presented updated results from the phase 1/2 ReFocus trial (NCT04526106) with the agent at the 2023…
A G1528C Hadha knock-in mouse model recapitulates aspects of human clinical phenotypes for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency
All animal procedures were reviewed and approved by the OHSU IACUC (eIACUC #B11243). All experiments were performed in accordance with AAALAC and ARRIVE guidelines. Age, sex, and N of the mice for each experiment can be found in Supplementary Data 1. Mouse creation Mice were created through Cyagen Biosciences (Santa Clara,…
Can policy get smart enough to catch up to artificial intelligence?
Artificial intelligence offers enormous potential for good. For example, the Beatles used AI technology to extract the musicians’ voices from an old demo cassette and produce a new song. And a new AI tool called AlphaFold boosted medical science by predicting the structures of nearly 200 million proteins. For all its…
Rapid genetic testing for sick infants could soon be covered by Medicaid
TUCSON, Ariz. (13 News) – Rapid genetic testing is helping to find thousands of rare diseases in newborns at birth, and Arizona just joined eight states to cover the cost for Medicaid patients. Every day in Arizona babies are born with rare genetic diseases. “One to five percent of all…
AMD’s Sub $100 US Ryzen CPU Converted Into a 16 GB GPU For AI, Delivers Solid Performance
In the era of AI, the demand for GPUs such as the H100 has risen tremendously, making it difficult for an average consumer to acquire one. However, a Reddit user has created a unique solution, converting the AMD Zen 2-based Ryzen 5 4600G “Renoir” APU into a 16 GB GPU…
The progress of novel strategies on immune-based therapy in relapsed or refractory diffuse large B-cell lymphoma
Susanibar-Adaniya S, Barta SK. 2021 Update on diffuse large B cell lymphoma: a review of current data and potential applications on risk stratification and management. Am J Hematol. 2021;96:617–29. Article PubMed PubMed Central Google Scholar Rovira J, Valera A, Colomo L, Setoain X, Rodriguez S, Martinez-Trillos A, et al. Prognosis…
Drug Modeling Software Market to Witness Revolutionary Growth by 2028
PRESS RELEASE Published August 11, 2023 Advance Market Analytics published a new research publication on “Global Drug Modeling Software Market Insights, to 2028” with 232 pages and enriched with self-explained Tables and charts in presentable format. In the study, you will find new evolving Trends, Drivers, Restraints, Opportunities generated by…
Mayo Clinic hiring Intern Bioinformatics (PhD) Remote – AI&I in Rochester, Minnesota, United States
Why Mayo ClinicMayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to…
Traffic Signs | Regulatory Signs | Traffic Signs
Why Traffic Sign Corporation We offer municipal grade, professional MUTCD regulatory traffic signs that do not rust and can easily withstand harsh weather conditions for many years. We do accept government purchase orders. No order is too big or small. We proudly serve the traffic sign needs of states, counties,…
Major Breakthrough in Clinical Trial of Tinlarebant for Geographic Atrophy in Australia
Belite Bio, a leading biopharmaceutical company specializing in drug development, has recently obtained approval from the Human Research Ethics Committee (HREC) to commence the highly anticipated Phase 3 clinical trial of Tinlarebant for Geographic Atrophy (GA) in Australia. This groundbreaking trial marks a crucial step forward in the fight against…
Intern Bioinformatics (PhD) Remote – AI&I at Mayo Clinic
Why Mayo Clinic Mayo Clinic is top-ranked in more specialties than any other care provider according to U.S. News & World Report. As we work together to put the needs of the patient first, we are also dedicated to our employees, investing in competitive compensation and comprehensive benefit plans – to take…
Golden Valley man went missing before remains found in 2021
PHOENIX – Human remains found in the desert in northwestern Arizona two years ago have been identified through a genetic genealogy investigation, authorities said Thursday. The remains belong to Christopher Canning, 60, of Golden Valley, the Mohave County Sheriff’s Office announced. An official cause of death could not be determined…
Belite Bio Doses First Subject in Pivotal Phase 3 PHOENIX Trial Evaluating Oral Tinlarebant for GA
Belite Bio Doses First Subject in Pivotal Phase 3 PHOENIX Trial Evaluating Oral Tinlarebant for GA Tinlarebant (a/k/a LBS-008) is Belite Bio’s orally administered tablet intended to slow disease progression in subjects with Stargardt Disease (STGD1) and Geographic Atrophy (GA) in advanced Dry Age-related Macular Degeneration (Dry AMD) There are…
Molecularly Stratified Treatment Options in Primary Refractory DLBCL/HGBL with MYC and BCL2 or BCL6 Rearrangements (HGBL, NOS with MYC/BCL6)
Alaggio R, Amador C, Anagnostopoulos I, Attygalle AD, Araujo IBO, Berti E, et al. The 5th ediition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia. 2022;36(7):1720–48. doi.org/10.1038/s41375-022-01620-2. Article PubMed PubMed Central Google Scholar Künstner A, Witte HM, Riedl J, Bernard V, Stolting S, Merz H, et…
Belite Bio Completes Enrollment in Pivotal Global Phase 3 DRAGON Trial Evaluating Oral Tinlarebant for Stargardt Disease
Belite Bio Completes Enrollment in Pivotal Global Phase 3 DRAGON Trial Evaluating Oral Tinlarebant for Stargardt Disease Tinlarebant (a/k/a LBS-008) is Belite Bio’s orally administered tablet intended to slow disease progression in patients with Stargardt Disease (STGD1) and Geographic Atrophy (GA) in advanced Dry Age-related Macular Degeneration (Dry AMD) 90…
Belite Bio Completes Enrollment in Pivotal Global Phase 3 DRAGON Trial Evaluating Oral … | News
Tinlarebant (a/k/a LBS-008) is Belite Bio’s orally administered tablet intended to slow disease progression in patients with Stargardt Disease (STGD1) and Geographic Atrophy (GA) in advanced Dry Age-related Macular Degeneration (Dry AMD) 90 patients completed enrollment across 11 countries worldwide Interim safety and efficacy data from the Phase 3 “DRAGON”…
Belite Bio Completes Enrollment in Pivotal Global Phase 3 DRAGON Trial Evaluating Oral Tinlarebant for Stargardt Disease – Belite Bio (NASDAQ:BLTE)
Tinlarebant (a/k/a LBS-008) is Belite Bio’s orally administered tablet intended to slow disease progression in patients with Stargardt Disease (STGD1) and Geographic Atrophy (GA) in advanced Dry Age-related Macular Degeneration (Dry AMD) 90 patients completed enrollment across 11 countries worldwide Interim safety and efficacy data from the Phase 3 “DRAGON”…
Belite Bio Completes Enrollment in Pivotal Global Phase 3
Tinlarebant (a/k/a LBS-008) is Belite Bio’s orally administered tablet intended to slow disease progression in patients with Stargardt Disease (STGD1) and Geographic Atrophy (GA) in advanced Dry Age-related Macular Degeneration (Dry AMD) 90 patients completed enrollment across 11 countries worldwide Interim safety and efficacy data from the Phase 3 “DRAGON”…
Enzyme stabilization and thermotolerance function of the intrinsically disordered LEA2 proteins from date palm
Hernández-Sánchez, et al. LEAfing through literature: Late embryogenesis abundant proteins coming of age-achievements and perspectives. J. Exp. Bot. 73, 6525–6546 (2020). Article Google Scholar Graether, S. P. Proteins involved in plant dehydration protection: The late embryogenesis abundant family. Biomolecules 12, 1380 (2022). Article CAS PubMed PubMed Central Google Scholar Dure,…
Lawmakers ask EPA to reconsider Phase 3 emissions regs
Trucking news and briefs for Friday, July 21, 2023: Bipartisan, bicameral letter slams EPA’s Phase 3 GHG regs Congressmen Doug LaMalfa (R-California) and Chris Pappas (D-New Hampshire) led 30 other members of Congress in sending a letter urging the Environmental Protection Agency (EPA) to reconsider its new Phase 3 Heavy-Duty Truck…
DNA identifies remains as man missing since 2019: AZ cops
Jordan Victor Carvalho, 30, disappeared in 2019, deputies said. Human remains found in 2022 in Golden Valley, Arizona, were recently identified as belonging to the missing man. Mohave County Sheriff’s Office Human remains found after flooding were identified through DNA evidence as an Arizona man who disappeared in 2019, authorities…
Staff Scientist – Translational Bioinformatics
Job Description About City of Hope City of Hope’s mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913,City of Hopehas grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers…
Novel Genetic Sequencing Technology Helps Researchers Find Answers in Cases of Pediatric Rare Disorders
The study identified likely cause of genetic disorder in six families PHOENIX and SAN DIEGO, July 10, 2023 /PRNewswire/ — A new genetic sequencing technology from Element Biosciences has helped researchers from the Translational Genomics Research Institute (TGen), part of the City of Hope, identify the likely genetic causes of…
Belite Bio submits application to expand PHOENIX phase 3 clinical trial to Taiwan
This trial is testing tinlarebant, a novel oral therapy which is intended to reduce the accumulation of toxins in the eye that cause STGD1 and contribute to geographic atrophy (GA). (Image Credit: neirfy/Adobe Stock) Belite Bio, Inc has submitted an application to the Taiwan Food and Drug Administration to initiate…
Brent Sam hat-trick puts Defence Force in quarter-finals
Sports Jelani Beckles An Hour Ago Defence Force striker Brent Sam. – (FILE) DEFENCE Force made a convincing start in their effort to win another title this season when the Army men destroyed Prisons Service FC 5-1 in the round of 16 of the TT Premier Football League Knock-out Cup…
Efficacy of RLY-4008 Signals Potential Role for Selective FGFR2 Inhibition in FGFR2-altered Cholangiocarcinoma
The preliminary clinical activity and durability observed with the first-in-class, highly selective FGFR2 inhibitor RLY-4008 in patients with FGFR2-altered cholangiocarcinoma, including those previously treated with an FGFR inhibitor, indicate that selective and irreversible FGFR2 inhibition may be a promising new strategy in this space, according to Mitesh J. Borad, MD….
Mismatch Repair Deficiency Shapes Tumor-Agnostic Use of Immunotherapy
Cancer immunotherapies have transformed the treatment landscape of many tumor types by stimulating the body’s mechanisms of targeting cancer cells. The efficacy of immune checkpoint inhibitors (ICIs) can vary widely between different tumor types based on immunogenicity and other factors—even patients with the same disease may respond very differently to…
After 22 years, Gray County Jane Doe is Identified
Summary In August 1999, the Texas Rangers were called to assist with an unidentified body of an adult female along I-40 west of McLean, Texas. Investigators attempted to identify the female by fingerprint, DNA, and composite sketch; however, those efforts were unsuccessful. A DNA profile was developed and entered into…
Prevalence and clonal diversity of carbapenem-resistant Klebsiella pneumoniae causing neonatal infections: A systematic review of 128 articles across 30 countries
Citation: Hu Y, Yang Y, Feng Y, Fang Q, Wang C, Zhao F, et al. (2023) Prevalence and clonal diversity of carbapenem-resistant Klebsiella pneumoniae causing neonatal infections: A systematic review of 128 articles across 30 countries. PLoS Med 20(6): e1004233. doi.org/10.1371/journal.pmed.1004233 Received: July 13, 2022; Accepted: April 4, 2023; Published:…
ASCO 2023: Studies Clarify Role of Immunotherapy in Multiple Myeloma
Four studies presented at the ASCO Annual Meeting 2023 further clarify the role of immunotherapy in the treatment of multiple myeloma (MM). Results from the phase 3 CARTITUDE-4 trial suggested that a chimeric antigen receptor (CAR) T-cell therapy could be used earlier in the course of MM treatment.1 The study…
Belite Bio: Undercovered Eye Disease Company With Early Data (NASDAQ:BLTE)
esp_imaging/E+ via Getty Images Belite Bio (NASDAQ:BLTE) is a small company with multiple phase 3 trials targeting retinal degenerative eye diseases. The stock looks interesting, with late-stage trials in indications without approved drugs. There are reasons, discussed later, which precludes my taking a more bullish stance. However, the stock is…
South Korea’s MFDS approved initiation of Phase 3 tinlarebant clinical trial for Stargardt Disease
Tinlarebant is a novel oral therapy which is intended to reduce the accumulation of toxins in the eye that cause STGD1 and contribute to GA, or advanced Dry AMD. (Image Credit: Adobe Stock/Sawbear Photography) Belite Bio, Inc announced via a press release1 the approval of the company’s Clinical Trial Application…
The Caris Precision Oncology Alliance Welcomes SWOG Cancer Research Network
SWOG Cancer Research Network joins Caris’ extensive network of leading cancer institutions and research consortia committed to improving patient outcomes through innovations in precision medicine IRVING, Texas, June 14, 2023 /PRNewswire/ — Caris Life Sciences®(Caris), the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize…
Research Associate – Dept. of Microbiology and Immunology
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Phase 1 Data Support Further Investigation of RLY-4008 in FGFR2+ Cholangiocarcinoma
The FGFR2 inhibitor RLY-4008 generated early evidence of efficacy in patients with cholangiocarcinoma harboring FGFR2 fusions, according to findings from the phase 1/2 ReFocus trial (NCT04526106), which were presented at the 2023 ASCO Annual Meeting.1 Results from the study showed that the patients with FGFR inhibitor–naïve, FGFR2 fusion–positive cholangiocarcinoma who…
City of Hope hiring Staff Scientist – Translational Bioinformatics in Duarte, California, United States
About City Of HopeCity of Hope’s mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers for…
Staff Scientist – Translational Bioinformatics job with City of Hope
About City of Hope City of Hope’s mission is to deliver the cures of tomorrow to the people who need them today. Founded in 1913, City of Hope has grown into one of the largest cancer research and treatment organizations in the U.S. and one of the leading research centers…
Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study
We thank the trial participants, their families and our fellow investigators involved in this trial: B. Suter (Texas Children’s Hospital, Houston, Texas, US), C. Buhrfiend, P. Heydemann (Rush University Children’s Hospital, Chicago, Illinois, US), S. Standridge, E. Broomall, K. Peariso (Cincinnati Children’s Hospital Medical Center, Division of Neurology and University…